VGF

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is specifically expressed in a subpopulation of neuroendocrine cells, and is upregulated by nerve growth factor. The structural organization of this gene is similar to that of the rat gene, and both the translated and the untranslated regions show a high degree of sequence similarity to the rat gene. The encoded secretory protein also shares similarities with the secretogranin/chromogranin family, however, its exact function is not known. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1basement membrane organization (GO:0071711)7.23719464
2regulation of short-term neuronal synaptic plasticity (GO:0048172)6.94373574
3synaptic vesicle maturation (GO:0016188)6.90558787
4enteric nervous system development (GO:0048484)5.97810814
5locomotory exploration behavior (GO:0035641)5.96362862
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.68672483
7protein retention in ER lumen (GO:0006621)5.63530751
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.43242029
9maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.25382333
10vocalization behavior (GO:0071625)5.19281569
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.17786390
12regulation of synaptic vesicle exocytosis (GO:2000300)5.14965385
13glutamate secretion (GO:0014047)5.13948698
14synaptic vesicle exocytosis (GO:0016079)5.06218438
15developmental pigmentation (GO:0048066)5.02902928
16regulation of glutamate receptor signaling pathway (GO:1900449)4.96921895
17synaptic vesicle docking involved in exocytosis (GO:0016081)4.93142951
18pigment cell differentiation (GO:0050931)4.86241105
19layer formation in cerebral cortex (GO:0021819)4.83438746
20melanocyte differentiation (GO:0030318)4.80477247
21neurotransmitter secretion (GO:0007269)4.62371691
22neuron cell-cell adhesion (GO:0007158)4.61388027
23proline transport (GO:0015824)4.61190780
24protein localization to synapse (GO:0035418)4.58358692
25amyloid precursor protein catabolic process (GO:0042987)4.54881077
26regulation of neuronal synaptic plasticity (GO:0048168)4.53232727
27tyrosine metabolic process (GO:0006570)4.52634404
28regulation of synaptic vesicle transport (GO:1902803)4.49798415
29exploration behavior (GO:0035640)4.44294957
30regulation of long-term neuronal synaptic plasticity (GO:0048169)4.43469780
31phenol-containing compound biosynthetic process (GO:0046189)4.29937436
32COPI coating of Golgi vesicle (GO:0048205)4.29459949
33Golgi transport vesicle coating (GO:0048200)4.29459949
34* response to dietary excess (GO:0002021)4.27499802
35dendritic spine morphogenesis (GO:0060997)4.15852037
36ionotropic glutamate receptor signaling pathway (GO:0035235)4.15308297
37glycine transport (GO:0015816)4.14152480
38gamma-aminobutyric acid transport (GO:0015812)4.12369368
39activation of protein kinase A activity (GO:0034199)4.07831652
40regulation of synapse structural plasticity (GO:0051823)4.07177730
41endosome to pigment granule transport (GO:0043485)4.06030179
42endosome to melanosome transport (GO:0035646)4.06030179
43chondroitin sulfate catabolic process (GO:0030207)3.98505485
44positive regulation of synaptic transmission, GABAergic (GO:0032230)3.97974233
45neuronal action potential propagation (GO:0019227)3.96424045
46L-serine transport (GO:0015825)3.96366478
47negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.91349322
48regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.90255649
49endothelial cell morphogenesis (GO:0001886)3.90054297
50endoplasmic reticulum calcium ion homeostasis (GO:0032469)3.85437231
51sodium ion export (GO:0071436)3.84591753
52cellular potassium ion homeostasis (GO:0030007)3.78645161
53neurotransmitter-gated ion channel clustering (GO:0072578)3.77692181
54neuromuscular process controlling balance (GO:0050885)3.77128984
55synaptic transmission, glutamatergic (GO:0035249)3.74933238
56neuromuscular process controlling posture (GO:0050884)3.73202715
57serine transport (GO:0032329)3.65368352
58neurotransmitter transport (GO:0006836)3.65312013
59positive regulation of neuroblast proliferation (GO:0002052)3.64878029
60cerebellar Purkinje cell layer development (GO:0021680)3.58789719
61positive regulation of membrane potential (GO:0045838)3.58147093
62negative regulation of macroautophagy (GO:0016242)3.56572127
63long-term memory (GO:0007616)3.49562967
64neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.49242034
65suckling behavior (GO:0001967)3.48550881
66amyloid precursor protein metabolic process (GO:0042982)3.48482911
67cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.45916329
68neuron-neuron synaptic transmission (GO:0007270)3.44512759
69regulation of excitatory postsynaptic membrane potential (GO:0060079)3.44148684
70regulation of neurotransmitter levels (GO:0001505)3.44070173
71cAMP biosynthetic process (GO:0006171)3.43666259
72glutamate receptor signaling pathway (GO:0007215)3.41956532
73transferrin transport (GO:0033572)3.40469435
74regulation of synaptic plasticity (GO:0048167)3.40386796
75positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.36570811
76membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.35066180
77regulation of neurotransmitter secretion (GO:0046928)3.32891856
78innervation (GO:0060384)3.32279838
79lung morphogenesis (GO:0060425)3.31812648
80cell communication by electrical coupling (GO:0010644)3.30948309
81semaphorin-plexin signaling pathway (GO:0071526)3.30257001
82neuron recognition (GO:0008038)3.30183407
83positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)3.29374486
84regulation of postsynaptic membrane potential (GO:0060078)3.28299356
85peptidyl-proline hydroxylation (GO:0019511)3.28142296
86regulation of early endosome to late endosome transport (GO:2000641)3.27867250
87postsynaptic membrane organization (GO:0001941)3.27636624
88energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.27482291
89ATP hydrolysis coupled proton transport (GO:0015991)3.27482291
90negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.27076948
91auditory behavior (GO:0031223)3.26845622
92response to auditory stimulus (GO:0010996)3.25171982
93positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.24233612
94regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.24163550
95dermatan sulfate biosynthetic process (GO:0030208)3.23859000
96vesicle transport along microtubule (GO:0047496)3.23402066
97regulation of dendritic spine morphogenesis (GO:0061001)3.23355086
98oligodendrocyte differentiation (GO:0048709)3.23233318
99alanine transport (GO:0032328)3.22710378
100retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.21733868
101G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.20398067
102negative regulation of microtubule polymerization (GO:0031115)3.19951316
103prepulse inhibition (GO:0060134)3.18691498
104cell migration in hindbrain (GO:0021535)3.17306539
105transmission of nerve impulse (GO:0019226)3.14832326
106regulation of vesicle fusion (GO:0031338)3.14239595
107regulation of neurotransmitter transport (GO:0051588)3.14087631
108ferric iron transport (GO:0015682)3.12583550
109trivalent inorganic cation transport (GO:0072512)3.12583550
110calcium-mediated signaling using intracellular calcium source (GO:0035584)3.12432339
111neuronal ion channel clustering (GO:0045161)3.12372649
112mating behavior (GO:0007617)3.12080855
113dendritic spine organization (GO:0097061)3.09672115
114intraspecies interaction between organisms (GO:0051703)3.09371378
115social behavior (GO:0035176)3.09371378
116regulation of ARF protein signal transduction (GO:0032012)3.08736278
117neuroepithelial cell differentiation (GO:0060563)3.08330353
118negative regulation of leukocyte chemotaxis (GO:0002689)3.07701571
119adhesion of symbiont to host (GO:0044406)3.07429024
120positive regulation of neurotransmitter transport (GO:0051590)3.07401752
121dendrite morphogenesis (GO:0048813)3.07028490
122dermatan sulfate metabolic process (GO:0030205)3.06726537
123secondary metabolic process (GO:0019748)3.06451122
124positive regulation of neurotransmitter secretion (GO:0001956)3.05967461
125axonal fasciculation (GO:0007413)3.04908862
126positive regulation of protein dephosphorylation (GO:0035307)3.04803135
127synaptic vesicle endocytosis (GO:0048488)3.03453834
128sequestering of extracellular ligand from receptor (GO:0035581)3.03084039
129positive regulation of synapse maturation (GO:0090129)3.02824324
130long-term synaptic potentiation (GO:0060291)3.02716437
131regulation of female receptivity (GO:0045924)3.01935334
132membrane protein ectodomain proteolysis (GO:0006509)3.01889752
133virion attachment to host cell (GO:0019062)3.00621994
134adhesion of symbiont to host cell (GO:0044650)3.00621994
135neuromuscular process (GO:0050905)2.99535054
136negative regulation of catenin import into nucleus (GO:0035414)2.99127814
137regulation of gonadotropin secretion (GO:0032276)2.98429703
138regulation of synaptic transmission, glutamatergic (GO:0051966)2.96565477
139positive regulation of synaptic transmission (GO:0050806)2.96079925
140regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.96043423
141axon cargo transport (GO:0008088)2.95495488
142glycosphingolipid catabolic process (GO:0046479)2.95468761
143protein maturation by protein folding (GO:0022417)2.94847701
144cerebellar Purkinje cell differentiation (GO:0021702)2.92133312
145positive regulation of axon extension (GO:0045773)2.90115177
146regulation of synaptic transmission (GO:0050804)2.88943814
147adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.88858963
148pigment biosynthetic process (GO:0046148)2.87642737
149membrane protein intracellular domain proteolysis (GO:0031293)2.87517002
150glial cell migration (GO:0008347)2.87249584
151regulation of glutamate secretion (GO:0014048)2.86928101
152axon regeneration (GO:0031103)2.86254643
153organelle transport along microtubule (GO:0072384)2.84566073
154skin morphogenesis (GO:0043589)2.84189362
155membrane depolarization during action potential (GO:0086010)2.83898359
156learning (GO:0007612)2.83665457
157membrane hyperpolarization (GO:0060081)2.82344890
158L-alpha-amino acid transmembrane transport (GO:1902475)2.82268675
159response to parathyroid hormone (GO:0071107)2.82226347
160dopamine receptor signaling pathway (GO:0007212)2.81996091
161membrane depolarization (GO:0051899)2.81690893
162gamma-aminobutyric acid signaling pathway (GO:0007214)2.81560128
163positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.80242310
164chondroitin sulfate biosynthetic process (GO:0030206)2.75255394
165negative regulation of glycogen metabolic process (GO:0070874)2.73203176
166regulation of mammary gland epithelial cell proliferation (GO:0033599)2.72942242
167glycolipid catabolic process (GO:0019377)2.71701335
168purine nucleotide transport (GO:0015865)2.70468372
169protein insertion into membrane (GO:0051205)2.68967140
170protein localization to endosome (GO:0036010)2.66019237
171negative regulation of glycoprotein biosynthetic process (GO:0010561)2.65313009
172protein heterotrimerization (GO:0070208)2.64445562
173basic amino acid transport (GO:0015802)2.62035898
174mitochondrion transport along microtubule (GO:0047497)2.54890191
175establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.54890191
176axon development (GO:0061564)2.54739700
177purine ribonucleotide transport (GO:0015868)2.54047008
178GDP-mannose metabolic process (GO:0019673)2.53221254
179negative regulation of homotypic cell-cell adhesion (GO:0034111)2.51370221
180melanin biosynthetic process (GO:0042438)12.6353007
181melanin metabolic process (GO:0006582)11.6516624
182secondary metabolite biosynthetic process (GO:0044550)10.2588027

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.72483173
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.01335070
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.08809474
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.04747249
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.00780809
6RARB_27405468_Chip-Seq_BRAIN_Mouse2.97518900
7* REST_21632747_ChIP-Seq_MESCs_Mouse2.91081144
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.82405479
9* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.80858619
10* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.80858619
11DROSHA_22980978_ChIP-Seq_HELA_Human2.75087771
12* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.67705991
13* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.63137031
14EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.59309414
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.56321801
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.55817589
17REST_18959480_ChIP-ChIP_MESCs_Mouse2.54159584
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.53614088
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.51197475
20GBX2_23144817_ChIP-Seq_PC3_Human2.49292956
21ELK3_25401928_ChIP-Seq_HUVEC_Human2.48163208
22* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.45589799
23* EZH2_27294783_Chip-Seq_ESCs_Mouse2.42690793
24MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.39924459
25CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.38587628
26IKZF1_21737484_ChIP-ChIP_HCT116_Human2.28883106
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.25995462
28* RNF2_27304074_Chip-Seq_ESCs_Mouse2.25563226
29EED_16625203_ChIP-ChIP_MESCs_Mouse2.22598662
30TET1_21451524_ChIP-Seq_MESCs_Mouse2.13052004
31ERG_21242973_ChIP-ChIP_JURKAT_Human2.10562533
32* RACK7_27058665_Chip-Seq_MCF-7_Human2.05892241
33RARG_19884340_ChIP-ChIP_MEFs_Mouse2.04101267
34PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.03796124
35* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.00593193
36UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.93734051
37NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.81816805
38TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.80461272
39CTCF_27219007_Chip-Seq_ERYTHROID_Human1.77289756
40* MITF_21258399_ChIP-Seq_MELANOMA_Human1.75614201
41CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.74105848
42* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.72554867
43YY1_21170310_ChIP-Seq_MESCs_Mouse1.70667549
44* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.68321526
45P300_27058665_Chip-Seq_ZR-75-30cells_Human1.68020555
46* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.63756359
47ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.62896945
48* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.62798995
49* KDM2B_26808549_Chip-Seq_K562_Human1.61280886
50SA1_27219007_Chip-Seq_ERYTHROID_Human1.57889245
51AR_21572438_ChIP-Seq_LNCaP_Human1.56306929
52* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.54634606
53* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.52001727
54* RING1B_27294783_Chip-Seq_ESCs_Mouse1.51412654
55SA1_27219007_Chip-Seq_Bcells_Human1.51338917
56CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.49947429
57* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.48779880
58SRY_22984422_ChIP-ChIP_TESTIS_Rat1.47569825
59VDR_21846776_ChIP-Seq_THP-1_Human1.46666194
60* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.45622103
61ELF1_20517297_ChIP-Seq_JURKAT_Human1.43966418
62GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.43666273
63* SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.43466995
64NR3C1_23031785_ChIP-Seq_PC12_Mouse1.40397187
65ZNF274_21170338_ChIP-Seq_K562_Hela1.39846522
66EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.39186041
67P68_20966046_ChIP-Seq_HELA_Human1.38336123
68TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.38225758
69RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.33772711
70CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.32579014
71CTBP2_25329375_ChIP-Seq_LNCAP_Human1.31762638
72CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.31494558
73KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.30504919
74ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.30433835
75* RING1B_27294783_Chip-Seq_NPCs_Mouse1.30333618
76GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.26319884
77WT1_25993318_ChIP-Seq_PODOCYTE_Human1.24840025
78* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.24520179
79SMAD4_21799915_ChIP-Seq_A2780_Human1.24484111
80PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.23108513
81ZFP281_27345836_Chip-Seq_ESCs_Mouse1.22104525
82ETS1_21867929_ChIP-Seq_TH2_Mouse1.22014383
83SOX2_21211035_ChIP-Seq_LN229_Gbm1.21644752
84CTCF_18555785_ChIP-Seq_MESCs_Mouse1.21069424
85TFEB_21752829_ChIP-Seq_HELA_Human1.17556385
86* SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.17211304
87TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.16251090
88JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.15748006
89PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.15056328
90AR_19668381_ChIP-Seq_PC3_Human1.14669498
91* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.13389402
92SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.12261029
93CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.11097935
94NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.10878683
95DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.10829226
96THAP11_20581084_ChIP-Seq_MESCs_Mouse1.10101444
97NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.09519072
98* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.09373532
99RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.09229266
100SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.09225441
101ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.09208529
102* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.08849902
103TP53_22127205_ChIP-Seq_IMR90_Human1.08546135
104CREB1_26743006_Chip-Seq_LNCaP_Human1.08032264
105CTCF_20526341_ChIP-Seq_ESCs_Human1.06800756
106RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.06362891
107OCT4_19829295_ChIP-Seq_ESCs_Human1.05321958
108NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.04907714
109TET1_21490601_ChIP-Seq_MESCs_Mouse1.04609787
110TP63_22573176_ChIP-Seq_HFKS_Human1.03880476
111DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.03307681
112BCL6_27268052_Chip-Seq_Bcells_Human1.03208693
113CTCF_27219007_Chip-Seq_Bcells_Human1.02220782
114DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.01571241
115* TP53_20018659_ChIP-ChIP_R1E_Mouse0.99080598
116CTBP1_25329375_ChIP-Seq_LNCAP_Human0.98914591
117ZNF217_24962896_ChIP-Seq_MCF-7_Human0.97598943
118PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.96202459
119* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.95566437
120LXR_22292898_ChIP-Seq_THP-1_Human0.94917786
121STAT3_23295773_ChIP-Seq_U87_Human0.94578813
122THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.94281217
123SMAD3_21741376_ChIP-Seq_ESCs_Human0.94210868
124YAP1_20516196_ChIP-Seq_MESCs_Mouse0.92420215
125SMAD3_21741376_ChIP-Seq_EPCs_Human0.92374660
126RXR_22108803_ChIP-Seq_LS180_Human0.92221256
127AR_25329375_ChIP-Seq_VCAP_Human0.91417678
128SMAD4_21741376_ChIP-Seq_HESCs_Human0.91069177
129TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.89678119
130VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.89532533
131CDX2_19796622_ChIP-Seq_MESCs_Mouse0.89213871
132OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.88774274
133AHR_22903824_ChIP-Seq_MCF-7_Human0.88086166
134* KDM2B_26808549_Chip-Seq_JURKAT_Human0.87027837
135ARNT_22903824_ChIP-Seq_MCF-7_Human0.86843233
136P53_22127205_ChIP-Seq_FIBROBLAST_Human0.86025047
137SMAD3_21741376_ChIP-Seq_HESCs_Human0.85364054
138SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85112286
139CBX2_27304074_Chip-Seq_ESCs_Mouse0.84226594
140MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.83394459
141* KDM2B_26808549_Chip-Seq_DND41_Human0.82591037
142KLF4_19829295_ChIP-Seq_ESCs_Human0.81667659
143SMAD_19615063_ChIP-ChIP_OVARY_Human0.81295000
144TOP2B_26459242_ChIP-Seq_MCF-7_Human0.79516590
145SMC4_20622854_ChIP-Seq_HELA_Human0.79507881
146TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.78530189
147RNF2_27304074_Chip-Seq_NSC_Mouse0.78206411
148TAF15_26573619_Chip-Seq_HEK293_Human0.78174465
149TCF4_23295773_ChIP-Seq_U87_Human0.78160474
150SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.77975146
151TP53_16413492_ChIP-PET_HCT116_Human0.77671072
152IGF1R_20145208_ChIP-Seq_DFB_Human0.76575653
153* BMI1_23680149_ChIP-Seq_NPCS_Mouse0.76244493

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005171_absent_coat_pigmentation6.98033233
2MP0004859_abnormal_synaptic_plasticity6.45578008
3MP0000372_irregular_coat_pigmentation6.05968971
4MP0005257_abnormal_intraocular_pressure5.38650588
5MP0003136_yellow_coat_color5.10372405
6MP0008438_abnormal_cutaneous_collagen5.07894571
7MP0005408_hypopigmentation4.93248693
8* MP0003635_abnormal_synaptic_transmissio4.02095023
9MP0003880_abnormal_central_pattern3.83980499
10MP0004270_analgesia3.49566715
11MP0005409_darkened_coat_color3.48105247
12MP0004381_abnormal_hair_follicle3.46264758
13MP0009745_abnormal_behavioral_response3.25316755
14* MP0002063_abnormal_learning/memory/cond3.12350642
15MP0002822_catalepsy3.00307544
16MP0002064_seizures2.97733692
17MP0005075_abnormal_melanosome_morpholog2.96623326
18MP0005423_abnormal_somatic_nervous2.85283403
19MP0001968_abnormal_touch/_nociception2.77595090
20MP0004858_abnormal_nervous_system2.76993955
21MP0009046_muscle_twitch2.70408669
22MP0004272_abnormal_basement_membrane2.69400658
23MP0002909_abnormal_adrenal_gland2.60373476
24MP0000015_abnormal_ear_pigmentation2.58390786
25MP0002572_abnormal_emotion/affect_behav2.56563459
26MP0002734_abnormal_mechanical_nocicepti2.52497205
27MP0005645_abnormal_hypothalamus_physiol2.44663394
28MP0009840_abnormal_foam_cell2.40370323
29MP0009780_abnormal_chondrocyte_physiolo2.32762911
30MP0003122_maternal_imprinting2.31152891
31MP0001501_abnormal_sleep_pattern2.27426020
32MP0002272_abnormal_nervous_system2.26264263
33MP0005058_abnormal_lysosome_morphology2.17670088
34MP0001486_abnormal_startle_reflex2.15482938
35MP0000371_diluted_coat_color2.12689436
36MP0002733_abnormal_thermal_nociception2.03368966
37MP0002735_abnormal_chemical_nociception2.02652181
38MP0002075_abnormal_coat/hair_pigmentati1.99274303
39MP0001440_abnormal_grooming_behavior1.98960041
40MP0003329_amyloid_beta_deposits1.97093650
41MP0001970_abnormal_pain_threshold1.94470871
42MP0002736_abnormal_nociception_after1.93233342
43MP0004811_abnormal_neuron_physiology1.90770729
44MP0002184_abnormal_innervation1.79542277
45MP0002095_abnormal_skin_pigmentation1.78633483
46MP0008569_lethality_at_weaning1.72068184
47MP0003787_abnormal_imprinting1.68830433
48MP0002557_abnormal_social/conspecific_i1.68063042
49MP0000955_abnormal_spinal_cord1.65417323
50MP0001186_pigmentation_phenotype1.64897366
51MP0002067_abnormal_sensory_capabilities1.61344396
52MP0000778_abnormal_nervous_system1.58384441
53MP0003283_abnormal_digestive_organ1.57024626
54MP0004885_abnormal_endolymph1.56459504
55MP0002089_abnormal_postnatal_growth/wei1.51632535
56MP0001849_ear_inflammation1.51201683
57MP0004924_abnormal_behavior1.49324442
58MP0005386_behavior/neurological_phenoty1.49324442
59MP0006276_abnormal_autonomic_nervous1.43565498
60MP0005646_abnormal_pituitary_gland1.41447873
61MP0003879_abnormal_hair_cell1.40631327
62MP0000013_abnormal_adipose_tissue1.40183720
63MP0002938_white_spotting1.38361081
64MP0003172_abnormal_lysosome_physiology1.36360598
65MP0002882_abnormal_neuron_morphology1.35435260
66* MP0002066_abnormal_motor_capabilities/c1.32949779
67MP0003633_abnormal_nervous_system1.30464702
68MP0003011_delayed_dark_adaptation1.28750849
69MP0001529_abnormal_vocalization1.22482714
70MP0003123_paternal_imprinting1.22327751
71MP0002295_abnormal_pulmonary_circulatio1.21562586
72MP0003075_altered_response_to1.21450262
73MP0005623_abnormal_meninges_morphology1.17883745
74MP0008872_abnormal_physiological_respon1.15181089
75MP0000569_abnormal_digit_pigmentation1.10342313
76MP0001324_abnormal_eye_pigmentation1.09783736
77MP0000751_myopathy1.08832440
78MP0001984_abnormal_olfaction1.08729500
79MP0003631_nervous_system_phenotype1.07186994
80MP0005167_abnormal_blood-brain_barrier1.05626921
81MP0002152_abnormal_brain_morphology1.03524273
82MP0002069_abnormal_eating/drinking_beha1.02034580
83MP0004233_abnormal_muscle_weight1.01386014
84* MP0001502_abnormal_circadian_rhythm1.00964694
85MP0002653_abnormal_ependyma_morphology1.00962017
86MP0004142_abnormal_muscle_tone0.99783641
87MP0002060_abnormal_skin_morphology0.97922856
88MP0001905_abnormal_dopamine_level0.95518666
89MP0001177_atelectasis0.93093041
90MP0003634_abnormal_glial_cell0.91228242
91MP0002229_neurodegeneration0.91047302
92MP0002090_abnormal_vision0.90667129
93MP0008874_decreased_physiological_sensi0.88672676
94MP0003690_abnormal_glial_cell0.87358748
95MP0000604_amyloidosis0.87172226
96MP0003045_fibrosis0.87015079
97MP0010234_abnormal_vibrissa_follicle0.84061600
98MP0004043_abnormal_pH_regulation0.83032449
99MP0010386_abnormal_urinary_bladder0.82596209
100MP0001915_intracranial_hemorrhage0.80848909
101MP0001299_abnormal_eye_distance/0.79619397
102MP0002638_abnormal_pupillary_reflex0.78344893
103MP0002751_abnormal_autonomic_nervous0.78078023
104MP0003632_abnormal_nervous_system0.77646054
105* MP0008961_abnormal_basal_metabolism0.76668370
106MP0001348_abnormal_lacrimal_gland0.75703545
107MP0003121_genomic_imprinting0.75082092
108MP0008770_decreased_survivor_rate0.74975982
109MP0000920_abnormal_myelination0.74952947
110MP0004085_abnormal_heartbeat0.74884576
111MP0002877_abnormal_melanocyte_morpholog0.74382908
112MP0005535_abnormal_body_temperature0.74281882
113MP0004264_abnormal_extraembryonic_tissu0.73699090
114MP0005499_abnormal_olfactory_system0.72612072
115MP0005394_taste/olfaction_phenotype0.72612072
116MP0000639_abnormal_adrenal_gland0.72077657
117MP0005379_endocrine/exocrine_gland_phen0.70888216
118MP0000003_abnormal_adipose_tissue0.70780763
119MP0005197_abnormal_uvea_morphology0.69221174
120MP0001664_abnormal_digestion0.68700481
121MP0005503_abnormal_tendon_morphology0.66698167
122MP0000631_abnormal_neuroendocrine_gland0.66669474
123MP0000534_abnormal_ureter_morphology0.66134786
124MP0005451_abnormal_body_composition0.64594858
125MP0000579_abnormal_nail_morphology0.63708103
126MP0001188_hyperpigmentation0.63061610
127MP0004130_abnormal_muscle_cell0.61804526
128MP0003646_muscle_fatigue0.60788242
129MP0000750_abnormal_muscle_regeneration0.60772765
130MP0000747_muscle_weakness0.60711339
131MP0002752_abnormal_somatic_nervous0.60685968
132MP0004484_altered_response_of0.59179907
133MP0004145_abnormal_muscle_electrophysio0.56956571
134MP0000358_abnormal_cell_content/0.52593403
135MP0003385_abnormal_body_wall0.50991400
136MP0009672_abnormal_birth_weight0.46507588
137MP0000367_abnormal_coat/_hair0.46045418
138MP0000462_abnormal_digestive_system0.45574462
139MP0005248_abnormal_Harderian_gland0.45040411
140MP0002177_abnormal_outer_ear0.43447617
141MP0009250_abnormal_appendicular_skeleto0.41123041
142MP0005174_abnormal_tail_pigmentation0.40270122
143MP0000681_abnormal_thyroid_gland0.38905097
144MP0009053_abnormal_anal_canal0.38718290

Predicted human phenotypes

RankGene SetZ-score
1Aplasia/Hypoplasia of the fovea (HP:0008060)9.24223925
2Hypoplasia of the fovea (HP:0007750)9.24223925
3Aplasia/Hypoplasia of the macula (HP:0008059)8.70366782
4Aplasia/Hypoplasia affecting the retina (HP:0008061)8.17386521
5Abnormality of the fovea (HP:0000493)7.34122285
6Myokymia (HP:0002411)6.52846029
7Focal motor seizures (HP:0011153)6.03864344
8Anterior segment dysgenesis (HP:0007700)5.18072252
9Visual hallucinations (HP:0002367)5.15318540
10Ocular albinism (HP:0001107)5.06954820
11Blue irides (HP:0000635)5.00637121
12Focal seizures (HP:0007359)4.98941019
13J-shaped sella turcica (HP:0002680)4.92508496
14Hand muscle atrophy (HP:0009130)4.58801966
15White forelock (HP:0002211)4.57977144
16Iris hypopigmentation (HP:0007730)4.57757586
17Patchy hypopigmentation of hair (HP:0011365)4.18856346
18Abnormality of liposaccharide metabolism (HP:0010968)4.12220085
19Abnormality of glycosphingolipid metabolism (HP:0004343)4.12220085
20Abnormality of glycolipid metabolism (HP:0010969)4.12220085
21Peripheral hypomyelination (HP:0007182)4.10727778
22Supranuclear gaze palsy (HP:0000605)4.06416752
23Distal upper limb amyotrophy (HP:0007149)3.93998630
24Upper limb amyotrophy (HP:0009129)3.93998630
25Hypopigmentation of the fundus (HP:0007894)3.91201414
26Large eyes (HP:0001090)3.88864869
27Ankle clonus (HP:0011448)3.87841083
28Atonic seizures (HP:0010819)3.77366554
29Epileptic encephalopathy (HP:0200134)3.74824680
30Action tremor (HP:0002345)3.69422453
31Depression (HP:0000716)3.58792762
32Absence seizures (HP:0002121)3.53854266
33Paraparesis (HP:0002385)3.52275406
34Generalized tonic-clonic seizures (HP:0002069)3.46472241
35Cerebral aneurysm (HP:0004944)3.45894519
36Pheochromocytoma (HP:0002666)3.43500652
37Febrile seizures (HP:0002373)3.40916181
38Spastic paraparesis (HP:0002313)3.39807219
39Papilledema (HP:0001085)3.39405029
40Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.38351294
41Hypercortisolism (HP:0001578)3.35837036
42Progressive cerebellar ataxia (HP:0002073)3.35144410
43Hypoplasia of the capital femoral epiphysis (HP:0003090)3.34056400
44Agitation (HP:0000713)3.33259574
45Shallow orbits (HP:0000586)3.28154782
46Cerebral hypomyelination (HP:0006808)3.22664652
47Impaired vibration sensation in the lower limbs (HP:0002166)3.22440434
48Mutism (HP:0002300)3.18848239
49Heterochromia iridis (HP:0001100)3.17425991
50Dialeptic seizures (HP:0011146)3.15830228
51Achilles tendon contracture (HP:0001771)3.15789288
52Urinary bladder sphincter dysfunction (HP:0002839)3.15312341
53Anxiety (HP:0000739)3.11921865
54Abnormality of the lower motor neuron (HP:0002366)3.08778193
55Akinesia (HP:0002304)3.07735356
56Poor eye contact (HP:0000817)3.05493259
57Alacrima (HP:0000522)3.02981060
58Postural instability (HP:0002172)2.99612437
59Premature rupture of membranes (HP:0001788)2.98486087
60Amblyopia (HP:0000646)2.95299178
61Impaired social interactions (HP:0000735)2.93191270
62Abnormal social behavior (HP:0012433)2.93191270
63Neuroendocrine neoplasm (HP:0100634)2.90667343
64Cerebral inclusion bodies (HP:0100314)2.82714087
65Abnormality of the Achilles tendon (HP:0005109)2.81962540
66Abnormal eating behavior (HP:0100738)2.81448022
67Neurofibrillary tangles (HP:0002185)2.79884586
68Increased cerebral lipofuscin (HP:0011813)2.79228337
69Hypokinesia (HP:0002375)2.75644623
70Truncal ataxia (HP:0002078)2.73687737
71Loss of speech (HP:0002371)2.73404136
72Ventricular fibrillation (HP:0001663)2.73310701
73Increased neuronal autofluorescent lipopigment (HP:0002074)2.68775672
74Absent epiphyses (HP:0010577)2.68201276
75Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.68201276
76Urinary urgency (HP:0000012)2.67750422
77Dysdiadochokinesis (HP:0002075)2.66446378
78Failure to thrive in infancy (HP:0001531)2.66333119
79Insomnia (HP:0100785)2.64149457
80Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.64141141
81Hyperacusis (HP:0010780)2.63868394
82Dysmetria (HP:0001310)2.63719493
83Genu recurvatum (HP:0002816)2.63192528
84Torticollis (HP:0000473)2.61515686
85Spastic gait (HP:0002064)2.60110042
86Genetic anticipation (HP:0003743)2.57552315
87Esotropia (HP:0000565)2.54113067
88Vertebral compression fractures (HP:0002953)2.53897651
89Distal lower limb muscle weakness (HP:0009053)2.53677579
90Hypoventilation (HP:0002791)2.51567052
91Menstrual irregularities (HP:0000858)2.50869342
92Broad-based gait (HP:0002136)2.47574369
93Deformed sella turcica (HP:0002681)2.43708108
94Hypoplasia of the iris (HP:0007676)2.43435273
95Termporal pattern (HP:0011008)2.43106909
96Insidious onset (HP:0003587)2.43106909
97Abnormality of the corticospinal tract (HP:0002492)2.40419436
98Bradykinesia (HP:0002067)2.39226852
99Neoplasm of the peripheral nervous system (HP:0100007)2.37243608
100Focal dystonia (HP:0004373)2.35881658
101Impaired smooth pursuit (HP:0007772)2.34962201
102Posterior embryotoxon (HP:0000627)2.34243317
103Morphological abnormality of the inner ear (HP:0011390)2.33033416
104Excessive salivation (HP:0003781)2.32330921
105Drooling (HP:0002307)2.32330921
106Bulbar palsy (HP:0001283)2.31580731
107Megalencephaly (HP:0001355)2.30627251
108Abnormality of calcium-phosphate metabolism (HP:0100530)2.27504445
109Gaze-evoked nystagmus (HP:0000640)2.26737279
110Intention tremor (HP:0002080)2.26192858
111Abnormality of binocular vision (HP:0011514)2.25767561
112Diplopia (HP:0000651)2.25767561
113Neuronal loss in central nervous system (HP:0002529)2.25348108
114Lower limb muscle weakness (HP:0007340)2.24234653
115Abnormality of the line of Schwalbe (HP:0008048)2.23578614
116Hemiplegia (HP:0002301)2.20930034
117Hyperthyroidism (HP:0000836)2.20540835
118Nonimmune hydrops fetalis (HP:0001790)2.19703572
119Abnormality of the anterior chamber (HP:0000593)2.19307586
120Decreased lacrimation (HP:0000633)2.18501399
121Stereotypic behavior (HP:0000733)2.17424641
122Progressive inability to walk (HP:0002505)2.16929186
123Turricephaly (HP:0000262)2.16361547
124Craniofacial dystonia (HP:0012179)2.14914373
125Epileptiform EEG discharges (HP:0011182)2.14441526
126Elfin facies (HP:0004428)2.13928307
127EEG with generalized epileptiform discharges (HP:0011198)2.12862270
128Macroorchidism (HP:0000053)2.12379477
129Pointed chin (HP:0000307)2.11934567
130Overriding aorta (HP:0002623)2.09881015
131Hypsarrhythmia (HP:0002521)2.09683370
132Polyphagia (HP:0002591)2.09149571
133Rapidly progressive (HP:0003678)2.08774106
134Ankyloglossia (HP:0010296)2.08099066
135Generalized hypopigmentation (HP:0007513)2.07783590
136Hemiparesis (HP:0001269)2.07000575
137Enlarged penis (HP:0000040)2.06703135
138Resting tremor (HP:0002322)2.06553749
139Clonus (HP:0002169)2.06487978
140Apathy (HP:0000741)2.05790444
141Hyperparathyroidism (HP:0000843)2.05719144
142Anosmia (HP:0000458)2.03979580
143Bundle branch block (HP:0011710)2.03559951
144Diminished movement (HP:0002374)2.03286171
145Abnormality of dentin (HP:0010299)2.03088123
146Trismus (HP:0000211)2.02686348
147Increased variability in muscle fiber diameter (HP:0003557)2.01806171
148Annular pancreas (HP:0001734)2.01098413
149Lower limb amyotrophy (HP:0007210)2.00459973
150Buphthalmos (HP:0000557)1.99145801
151Abnormality of ocular smooth pursuit (HP:0000617)1.98601966
152Generalized myoclonic seizures (HP:0002123)1.95783331
153Impaired vibratory sensation (HP:0002495)1.94650394
154Psychosis (HP:0000709)1.94070900
155Hyperventilation (HP:0002883)1.93824629
156Premature graying of hair (HP:0002216)1.93539096
157Bladder diverticulum (HP:0000015)1.92016073
158Dysmetric saccades (HP:0000641)1.90776313
159Status epilepticus (HP:0002133)1.90592736
160Centrally nucleated skeletal muscle fibers (HP:0003687)1.89739547
161Amyotrophic lateral sclerosis (HP:0007354)1.88710987
162Abnormal autonomic nervous system physiology (HP:0012332)1.88702429
163Delusions (HP:0000746)1.87371339
164Abnormal EKG (HP:0003115)1.86110002
165Restlessness (HP:0000711)1.85898627
166Diminished motivation (HP:0000745)1.85710879
167Nasal polyposis (HP:0100582)1.84723242
168Pathologic fracture (HP:0002756)1.83644890
169Scanning speech (HP:0002168)1.82748965
170Abnormal auditory evoked potentials (HP:0006958)1.79404647
171Spinal rigidity (HP:0003306)1.79231640
172Abnormality of skeletal muscle fiber size (HP:0012084)1.78870644
173Abnormality of the nasal mucosa (HP:0000433)1.78567321
174Upper limb muscle weakness (HP:0003484)1.77871931
175Elbow flexion contracture (HP:0002987)1.75398025
176Renovascular hypertension (HP:0100817)1.73685946
177Pustule (HP:0200039)1.72124944
178Poor head control (HP:0002421)1.71926044
179Cholecystitis (HP:0001082)1.67426070
180Abnormal gallbladder physiology (HP:0012438)1.67426070
181CNS hypomyelination (HP:0003429)1.67079422
182Mesangial abnormality (HP:0001966)1.66597515
183Premature skin wrinkling (HP:0100678)1.65062067
184Retinal atrophy (HP:0001105)1.64579404
185Prostate neoplasm (HP:0100787)1.63545589
186Abnormality of the salivary glands (HP:0010286)1.62151798
187Aqueductal stenosis (HP:0002410)1.57581372
188Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.56697396
189Abnormality of the musculature of the hand (HP:0001421)1.53592096
190Renal duplication (HP:0000075)1.52632205

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K94.65039486
2NTRK34.57370514
3EPHA43.71914296
4MAPKAPK33.50950675
5NTRK12.82924710
6SCYL22.73790162
7MARK12.69030229
8PRKD32.64940039
9MAP3K42.64777149
10MINK12.61638841
11PAK62.50934882
12DAPK22.48492042
13TESK12.44410652
14LIMK12.37196975
15KSR22.27773685
16NTRK22.22310986
17TESK22.10442504
18CAMKK12.01477529
19MAP3K111.94422232
20MAP2K71.89612117
21CSNK1G31.87879048
22ERN11.86600194
23MAP3K31.69741525
24PKN21.67542505
25MAP2K41.66472465
26ALK1.64636205
27MAP3K21.63675309
28CSNK1A1L1.62682136
29CDK51.56105126
30UHMK11.52976883
31NME21.48487663
32CSNK1G11.45783552
33MAP3K121.44074985
34TAOK11.39925167
35DMPK1.37633042
36RET1.34189044
37GRK51.34171897
38KSR11.33096522
39BRAF1.32808091
40TYRO31.30564348
41DAPK11.29156151
42EPHB11.26528058
43EPHA31.25546595
44LATS21.25502744
45DYRK21.25196030
46STK381.23895967
47RIPK41.22196827
48ABL21.22151557
49ARAF1.21208864
50TAOK21.19668691
51PLK21.16546588
52PRKCH1.13753584
53FES1.11223527
54SIK11.10167668
55CDK191.10040415
56PNCK1.07591873
57CAMK11.05537284
58PRKCG1.05527713
59PAK31.05194224
60SIK31.04913952
61WEE11.02453035
62SIK21.00146889
63LMTK20.99972822
64STK110.96525423
65MAP3K130.96459205
66MAP2K20.92051576
67MAP3K60.89151754
68RIPK10.88820750
69PKN10.88254131
70TNIK0.87382400
71MAP3K10.85410635
72NEK10.84219178
73CDK140.83692213
74CDK150.83421884
75PHKG10.83270426
76PHKG20.83270426
77CAMK2A0.83233401
78CAMKK20.83109817
79CDK180.82674874
80MAPK120.80000704
81PRPF4B0.77002344
82EPHB20.74766810
83PRKD20.74432869
84SGK4940.74402915
85SGK2230.74402915
86CDK11A0.72592300
87MARK20.70888009
88MAPK130.70531777
89MTOR0.69592215
90PTK20.66572055
91FER0.66185441
92MARK30.65449758
93CSNK1G20.65242431
94PDGFRA0.64866771
95BRSK10.64316799
96RPS6KA20.63901894
97CASK0.61596773
98RAF10.60171563
99PRKG20.59704347
100DAPK30.58878327
101RPS6KB20.58374307
102ILK0.57980257
103STK160.57071530
104PDK10.56227850
105DDR20.55552667
106SGK30.55359232
107CDC42BPA0.55359120
108MAPK40.55263140
109EEF2K0.54809897
110PDPK10.54354840
111SGK10.53173818
112CAMK1G0.53155902
113GSK3A0.53135993
114PTK60.52814354
115MAPK100.52550548
116TNK20.50529821
117TTN0.50449511
118CDK70.49090718
119PAK10.48687520
120CAMK40.48230892
121RPS6KA30.47440010
122PAK40.47226864
123CAMK2B0.47115393
124FYN0.46657224
125TRIB30.46595351
126PINK10.46447606
127SGK20.45912091
128MAP2K10.45591411
129PTK2B0.44264790
130PIM20.42056039
131PRKCZ0.41738967
132ICK0.41684694
133AKT20.40299808
134PRKD10.39624881
135LRRK20.38862182
136ROCK20.38218259
137MAP3K70.37941121
138PRKCE0.36450592
139DYRK1A0.36440830
140ERBB40.36415916
141ROCK10.34775018
142CSNK1E0.34485458
143HIPK20.33867321
144TBK10.33419787
145NEK60.31467152
146MAPK80.30912155
147CAMK2G0.29281896
148CAMK2D0.29205709
149PDGFRB0.28165566
150SRC0.27696612

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.59687471
2Nicotine addiction_Homo sapiens_hsa050333.13783887
3Other glycan degradation_Homo sapiens_hsa005112.75871686
4GABAergic synapse_Homo sapiens_hsa047272.67213795
5Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.66029492
6Olfactory transduction_Homo sapiens_hsa047402.55891688
7Circadian entrainment_Homo sapiens_hsa047132.51919489
8Long-term potentiation_Homo sapiens_hsa047202.33176834
9Morphine addiction_Homo sapiens_hsa050322.30266764
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.25403831
11Glutamatergic synapse_Homo sapiens_hsa047242.24977578
12Amphetamine addiction_Homo sapiens_hsa050312.22357767
13Glycosaminoglycan degradation_Homo sapiens_hsa005312.09558361
14Salivary secretion_Homo sapiens_hsa049702.07788602
15Insulin secretion_Homo sapiens_hsa049112.07391626
16Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.04242701
17Dopaminergic synapse_Homo sapiens_hsa047282.03039369
18Gastric acid secretion_Homo sapiens_hsa049711.87914654
19Cholinergic synapse_Homo sapiens_hsa047251.87095569
20Cocaine addiction_Homo sapiens_hsa050301.79530391
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.78105834
22Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.67028278
23Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.66560049
24N-Glycan biosynthesis_Homo sapiens_hsa005101.66380965
25Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.62733474
26Collecting duct acid secretion_Homo sapiens_hsa049661.56548711
27Long-term depression_Homo sapiens_hsa047301.56053281
28Renin secretion_Homo sapiens_hsa049241.53486008
29Oxytocin signaling pathway_Homo sapiens_hsa049211.47850381
30Notch signaling pathway_Homo sapiens_hsa043301.46569486
31Taste transduction_Homo sapiens_hsa047421.42831222
32GnRH signaling pathway_Homo sapiens_hsa049121.41514026
33Serotonergic synapse_Homo sapiens_hsa047261.38703540
34Type II diabetes mellitus_Homo sapiens_hsa049301.35751865
35Calcium signaling pathway_Homo sapiens_hsa040201.34379131
36Vibrio cholerae infection_Homo sapiens_hsa051101.32762767
37Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.30020735
38Estrogen signaling pathway_Homo sapiens_hsa049151.27891106
39Glioma_Homo sapiens_hsa052141.27050276
40Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.26796825
41Gap junction_Homo sapiens_hsa045401.26614101
42Oxidative phosphorylation_Homo sapiens_hsa001901.26256196
43Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.21799141
44Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.21028567
45Galactose metabolism_Homo sapiens_hsa000521.20094637
46Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.16293956
47cAMP signaling pathway_Homo sapiens_hsa040241.15149912
48Nitrogen metabolism_Homo sapiens_hsa009101.14031025
49Sphingolipid metabolism_Homo sapiens_hsa006001.12824132
50Melanogenesis_Homo sapiens_hsa049161.05705157
51Sulfur relay system_Homo sapiens_hsa041221.04002736
52Axon guidance_Homo sapiens_hsa043601.03272462
53ErbB signaling pathway_Homo sapiens_hsa040121.02792711
54Tyrosine metabolism_Homo sapiens_hsa003501.02250492
55Type I diabetes mellitus_Homo sapiens_hsa049401.00636276
56Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.99252126
57Phosphatidylinositol signaling system_Homo sapiens_hsa040700.98858530
58Alzheimers disease_Homo sapiens_hsa050100.94983111
59Phagosome_Homo sapiens_hsa041450.94205530
60cGMP-PKG signaling pathway_Homo sapiens_hsa040220.90612667
61Lysine degradation_Homo sapiens_hsa003100.88339160
62Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.88274908
63Phospholipase D signaling pathway_Homo sapiens_hsa040720.87944311
64Dorso-ventral axis formation_Homo sapiens_hsa043200.87878254
65Thyroid hormone synthesis_Homo sapiens_hsa049180.86937652
66mTOR signaling pathway_Homo sapiens_hsa041500.84845094
67Neurotrophin signaling pathway_Homo sapiens_hsa047220.84209667
68Oocyte meiosis_Homo sapiens_hsa041140.83573478
69Vascular smooth muscle contraction_Homo sapiens_hsa042700.83484897
70Cardiac muscle contraction_Homo sapiens_hsa042600.81389841
71Pancreatic secretion_Homo sapiens_hsa049720.78757701
72Dilated cardiomyopathy_Homo sapiens_hsa054140.78204727
73Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.78079734
74Bile secretion_Homo sapiens_hsa049760.73258621
75Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.72759100
76Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.72494627
77MAPK signaling pathway_Homo sapiens_hsa040100.71528319
78Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.69295626
79Carbohydrate digestion and absorption_Homo sapiens_hsa049730.67976843
80Parkinsons disease_Homo sapiens_hsa050120.67111956
81Fructose and mannose metabolism_Homo sapiens_hsa000510.66696799
82Endocytosis_Homo sapiens_hsa041440.64649636
83Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.63346963
84Arginine biosynthesis_Homo sapiens_hsa002200.62409053
85Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.62097549
86Glucagon signaling pathway_Homo sapiens_hsa049220.61525693
872-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.60933587
88VEGF signaling pathway_Homo sapiens_hsa043700.60617470
89Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.59961129
90Vitamin B6 metabolism_Homo sapiens_hsa007500.59649696
91Prion diseases_Homo sapiens_hsa050200.58667243
92Insulin signaling pathway_Homo sapiens_hsa049100.57973763
93Rheumatoid arthritis_Homo sapiens_hsa053230.57612727
94Choline metabolism in cancer_Homo sapiens_hsa052310.56495402
95Non-small cell lung cancer_Homo sapiens_hsa052230.56469083
96Rap1 signaling pathway_Homo sapiens_hsa040150.53568530
97Ras signaling pathway_Homo sapiens_hsa040140.52469764
98Alcoholism_Homo sapiens_hsa050340.51786232
99Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51662122
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.51477005
101Endometrial cancer_Homo sapiens_hsa052130.50466832
102Ovarian steroidogenesis_Homo sapiens_hsa049130.49833470
103Lysosome_Homo sapiens_hsa041420.49725413
104Renal cell carcinoma_Homo sapiens_hsa052110.49529885
105Salmonella infection_Homo sapiens_hsa051320.49450930
106Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.49161918
107Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.48419455
108Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.47722839
109AMPK signaling pathway_Homo sapiens_hsa041520.45886646
110Fatty acid elongation_Homo sapiens_hsa000620.45249968
111Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45169849
112Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.45150245
113Central carbon metabolism in cancer_Homo sapiens_hsa052300.43871673
114Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.43262324
115Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.42645758
116Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.42528911
117Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42414280
118Protein digestion and absorption_Homo sapiens_hsa049740.41801073
119Arginine and proline metabolism_Homo sapiens_hsa003300.41720062
120Pentose phosphate pathway_Homo sapiens_hsa000300.41416194
121Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.41294812
122Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.39425100
123Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.39259016
124Inositol phosphate metabolism_Homo sapiens_hsa005620.37714945
125Focal adhesion_Homo sapiens_hsa045100.37099193
126Thyroid cancer_Homo sapiens_hsa052160.36256706
127Bladder cancer_Homo sapiens_hsa052190.34702213
128Chemokine signaling pathway_Homo sapiens_hsa040620.33081885
129Wnt signaling pathway_Homo sapiens_hsa043100.31223013
130Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.30877698
131Prolactin signaling pathway_Homo sapiens_hsa049170.30136778
132Phototransduction_Homo sapiens_hsa047440.29938084
133SNARE interactions in vesicular transport_Homo sapiens_hsa041300.26381228
134Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.25507426

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