VGLL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene binds proteins of the TEA domain family of transcription factors (TEFs) through the Vg (vestigial) homology region found in its N-terminus. It may thus function as a specific coactivator for the mammalian TEFs. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)9.70928636
2piRNA metabolic process (GO:0034587)7.93621814
3bundle of His cell to Purkinje myocyte communication (GO:0086069)7.19316699
4mitotic metaphase plate congression (GO:0007080)6.27334848
5keratinocyte development (GO:0003334)5.54256925
6DNA methylation involved in gamete generation (GO:0043046)5.45624347
7negative regulation of keratinocyte proliferation (GO:0010839)5.43175692
8metaphase plate congression (GO:0051310)5.14152960
9regulation of histone H3-K27 methylation (GO:0061085)4.92218174
10regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.82184942
11regulation of female gonad development (GO:2000194)4.70896968
12establishment of chromosome localization (GO:0051303)4.65918347
13negative regulation of retinoic acid receptor signaling pathway (GO:0048387)4.57991267
14mitotic chromosome condensation (GO:0007076)4.55081494
15regulation of exit from mitosis (GO:0007096)4.53774438
16protein localization to kinetochore (GO:0034501)4.51911769
17interferon-gamma secretion (GO:0072643)4.45220164
18regulation of water loss via skin (GO:0033561)4.35935878
19histone H2A monoubiquitination (GO:0035518)4.34621869
20oocyte maturation (GO:0001556)4.30850690
21calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.27096034
22male meiosis (GO:0007140)4.26753986
23regulation of spindle organization (GO:0090224)4.20927431
24histone H2A ubiquitination (GO:0033522)4.20358106
25aminoglycoside antibiotic metabolic process (GO:0030647)4.19217065
26spindle checkpoint (GO:0031577)4.16073349
27regulation of meiosis (GO:0040020)4.13664461
28doxorubicin metabolic process (GO:0044598)4.08392099
29daunorubicin metabolic process (GO:0044597)4.08392099
30polyketide metabolic process (GO:0030638)4.08392099
31regulation of G0 to G1 transition (GO:0070316)4.00118435
32galactose catabolic process (GO:0019388)3.98160283
33DNA replication checkpoint (GO:0000076)3.94817334
34ribosome assembly (GO:0042255)3.93531480
35mitotic sister chromatid segregation (GO:0000070)3.91578955
36protein localization to chromosome, centromeric region (GO:0071459)3.87957359
37female gamete generation (GO:0007292)3.85625164
38folic acid metabolic process (GO:0046655)3.85335823
39protein K6-linked ubiquitination (GO:0085020)3.85164429
40synaptonemal complex assembly (GO:0007130)3.85027181
41regulation of cellular amino acid metabolic process (GO:0006521)3.80631208
42anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.80551002
43intestinal epithelial cell development (GO:0060576)3.78284231
44protein autoprocessing (GO:0016540)3.77240087
45rRNA modification (GO:0000154)3.76667975
46regulation of phospholipid biosynthetic process (GO:0071071)3.76244267
47regulation of chromosome segregation (GO:0051983)3.75261948
48regulation of meiosis I (GO:0060631)3.74273836
49DNA damage induced protein phosphorylation (GO:0006975)3.73749121
50flavonoid metabolic process (GO:0009812)3.72188464
51attachment of spindle microtubules to kinetochore (GO:0008608)3.72118776
52mitotic spindle checkpoint (GO:0071174)3.72050314
53positive regulation of chromosome segregation (GO:0051984)3.69118568
54hepatocyte apoptotic process (GO:0097284)3.65862216
55negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.64063697
56protein retention in ER lumen (GO:0006621)3.63964526
57maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.63759411
58galactose metabolic process (GO:0006012)3.61745457
59cell differentiation involved in embryonic placenta development (GO:0060706)3.60656799
60mitotic spindle assembly checkpoint (GO:0007094)3.60540944
61proteasome assembly (GO:0043248)3.60337658
62negative regulation of mitotic sister chromatid separation (GO:2000816)3.59471224
63negative regulation of mitotic sister chromatid segregation (GO:0033048)3.59471224
64negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.59471224
65negative regulation of sister chromatid segregation (GO:0033046)3.59471224
66protein localization to chromosome (GO:0034502)3.58633718
67negative regulation of chromosome segregation (GO:0051985)3.58060323
68meiotic nuclear division (GO:0007126)3.56888579
69establishment of skin barrier (GO:0061436)3.55335374
70spindle assembly checkpoint (GO:0071173)3.55133595
71maturation of 5.8S rRNA (GO:0000460)3.55081254
72regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.51910090
73labyrinthine layer development (GO:0060711)3.49703804
74CENP-A containing nucleosome assembly (GO:0034080)3.48935425
75negative regulation of meiosis (GO:0045835)3.48839125
76ncRNA 3-end processing (GO:0043628)3.48272442
77regulation of mitotic metaphase/anaphase transition (GO:0030071)3.48102991
78meiotic cell cycle (GO:0051321)3.47393100
79positive regulation of epidermal cell differentiation (GO:0045606)3.46674182
80primary alcohol catabolic process (GO:0034310)3.46569487
81regulation of sister chromatid cohesion (GO:0007063)3.45976248
82regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.45390860
83regulation of retinoic acid receptor signaling pathway (GO:0048385)3.44270349
84positive regulation of epidermis development (GO:0045684)3.43634867
85negative regulation of smooth muscle cell differentiation (GO:0051151)3.43390922
86gene silencing by RNA (GO:0031047)3.41786926
87synaptonemal complex organization (GO:0070193)3.41661997
88ribosomal small subunit biogenesis (GO:0042274)3.41371287
89chromosome segregation (GO:0007059)3.41328523
90histone exchange (GO:0043486)3.41137503
91positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.39759647
92GDP-mannose metabolic process (GO:0019673)3.38636055
93regulation of apoptotic process involved in morphogenesis (GO:1902337)3.38509432
94chromatin remodeling at centromere (GO:0031055)3.37473721
95folic acid transport (GO:0015884)3.36307439
96cornea development in camera-type eye (GO:0061303)3.35468254
97negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.33230885
98negative regulation of DNA-templated transcription, elongation (GO:0032785)3.33230885
99positive regulation of keratinocyte differentiation (GO:0045618)3.32503322
100regulation of double-strand break repair via homologous recombination (GO:0010569)3.30144393
101meiosis I (GO:0007127)3.29663295
102positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.29414313
103kinetochore assembly (GO:0051382)3.28722111
104rRNA methylation (GO:0031167)3.27625192
105citrulline biosynthetic process (GO:0019240)3.26743317
106regulation of telomere maintenance via telomerase (GO:0032210)3.26444944
107regulation of mitotic sister chromatid segregation (GO:0033047)3.26046946
108regulation of sister chromatid segregation (GO:0033045)3.26046946
109regulation of mitotic sister chromatid separation (GO:0010965)3.26046946
110DNA alkylation (GO:0006305)3.25532064
111DNA methylation (GO:0006306)3.25532064
112positive regulation of cellular amine metabolic process (GO:0033240)3.24991124
113DNA replication-independent nucleosome organization (GO:0034724)3.24467501
114DNA replication-independent nucleosome assembly (GO:0006336)3.24467501
115regulation of meiotic cell cycle (GO:0051445)3.23076313
116regulation of centrosome cycle (GO:0046605)3.22182163
117ear development (GO:0043583)3.21703642
118protein deneddylation (GO:0000338)3.21532071
119regulation of transforming growth factor beta2 production (GO:0032909)3.21448273
120positive regulation of Cdc42 GTPase activity (GO:0043089)3.21422241
121L-serine metabolic process (GO:0006563)3.19084137
122cysteine metabolic process (GO:0006534)3.16975637
123male meiosis I (GO:0007141)3.16854336
124meiotic cell cycle process (GO:1903046)3.16590451
125kinetochore organization (GO:0051383)3.13255090
126amyloid precursor protein metabolic process (GO:0042982)3.11666335
127negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.11177259
128regulation of integrin-mediated signaling pathway (GO:2001044)3.09450130
129mitotic nuclear envelope disassembly (GO:0007077)3.09432978
130protein K11-linked ubiquitination (GO:0070979)3.09366238
131phenylpropanoid metabolic process (GO:0009698)3.07725331
132nephron tubule formation (GO:0072079)3.07292774
133regulation of cardioblast differentiation (GO:0051890)3.07203723
134positive regulation of ligase activity (GO:0051351)3.06774617
135notochord development (GO:0030903)3.06625709
136DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.06614118
137sister chromatid segregation (GO:0000819)3.06509771
138negative regulation of mitosis (GO:0045839)3.06226068
139multicellular organismal water homeostasis (GO:0050891)3.05966890
140base-excision repair, AP site formation (GO:0006285)3.05738761
141negative regulation of nuclear division (GO:0051784)3.05472624
142diterpenoid biosynthetic process (GO:0016102)3.04496433
143branching involved in salivary gland morphogenesis (GO:0060445)3.03705982
144regulation of keratinocyte proliferation (GO:0010837)3.03381003
145intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.02096026
146signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.02096026
147antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.02031881
148negative regulation of transcription by competitive promoter binding (GO:0010944)3.02004324
149nucleoside transmembrane transport (GO:1901642)3.01055825
150membrane budding (GO:0006900)2.99758941
151RNA localization (GO:0006403)2.97435737
152ribosome biogenesis (GO:0042254)2.97225808
153signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.96280102
154signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.96280102
155signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.96280102
156establishment of apical/basal cell polarity (GO:0035089)2.95668185
157signal transduction involved in DNA damage checkpoint (GO:0072422)2.95243566
158signal transduction involved in DNA integrity checkpoint (GO:0072401)2.95243566
159glutathione biosynthetic process (GO:0006750)2.92620383
160COPI coating of Golgi vesicle (GO:0048205)2.90554544
161Golgi transport vesicle coating (GO:0048200)2.90554544
162positive regulation of hair follicle development (GO:0051798)2.89570249
163positive regulation of hair cycle (GO:0042635)2.89570249
164mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.87924365
165signal transduction involved in cell cycle checkpoint (GO:0072395)2.86888409
166regulation of cellular amine metabolic process (GO:0033238)2.86817224
167nucleoside salvage (GO:0043174)2.86401970
168response to water (GO:0009415)2.85229157
169ribonucleoprotein complex biogenesis (GO:0022613)2.85208200
170regulation of tight junction assembly (GO:2000810)2.82758357
171prostanoid biosynthetic process (GO:0046457)2.79601034
172prostaglandin biosynthetic process (GO:0001516)2.79601034
173negative regulation of ligase activity (GO:0051352)2.79308082
174negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.79308082
175vitamin transmembrane transport (GO:0035461)2.78688561
176norepinephrine metabolic process (GO:0042415)2.78649527
177cellular glucuronidation (GO:0052695)2.78518931
178tight junction assembly (GO:0070830)2.76075644
179antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.75245392
180gap junction assembly (GO:0016264)2.74749520
181vesicle targeting (GO:0006903)2.73960805
182purine nucleotide salvage (GO:0032261)2.72646751
183polarized epithelial cell differentiation (GO:0030859)2.72288596
184regulation of hippo signaling (GO:0035330)2.71266067
185pentose-phosphate shunt (GO:0006098)2.70776763
186branching involved in labyrinthine layer morphogenesis (GO:0060670)2.70494128
187regulation of keratinocyte differentiation (GO:0045616)2.70001791

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.42240687
2E2F7_22180533_ChIP-Seq_HELA_Human5.27974001
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.37572044
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.15364249
5AR_21909140_ChIP-Seq_LNCAP_Human3.79642019
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.27567198
7ESR2_21235772_ChIP-Seq_MCF-7_Human3.26149234
8SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.23989376
9MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.11148770
10E2F4_17652178_ChIP-ChIP_JURKAT_Human3.02847419
11ESR1_21235772_ChIP-Seq_MCF-7_Human2.95708442
12NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.89913616
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.86870052
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.79209394
15SALL1_21062744_ChIP-ChIP_HESCs_Human2.74151676
16KAP1_22055183_ChIP-Seq_ESCs_Mouse2.71990870
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.69512482
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.67344928
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.63670242
20ESR1_15608294_ChIP-ChIP_MCF-7_Human2.55854979
21EST1_17652178_ChIP-ChIP_JURKAT_Human2.51691884
22RACK7_27058665_Chip-Seq_MCF-7_Human2.47901644
23RARG_19884340_ChIP-ChIP_MEFs_Mouse2.46676776
24MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.35337360
25TP63_17297297_ChIP-ChIP_HaCaT_Human2.31127872
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.21099053
27MYCN_18555785_ChIP-Seq_MESCs_Mouse2.17666505
28NANOG_18555785_ChIP-Seq_MESCs_Mouse2.15923047
29MYC_19030024_ChIP-ChIP_MESCs_Mouse2.10368551
30ESR1_20079471_ChIP-ChIP_T-47D_Human2.10285053
31PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.07068304
32STAT6_21828071_ChIP-Seq_BEAS2B_Human2.01203149
33KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.96607977
34CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.96580759
35MYC_19079543_ChIP-ChIP_MESCs_Mouse1.94864328
36POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.94086664
37NELFA_20434984_ChIP-Seq_ESCs_Mouse1.92306728
38TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.92158543
39KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.90356631
40MYC_18358816_ChIP-ChIP_MESCs_Mouse1.89285058
41HIF1A_21447827_ChIP-Seq_MCF-7_Human1.84048537
42TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.80270795
43GATA1_26923725_Chip-Seq_HPCs_Mouse1.77192549
44E2F1_21310950_ChIP-Seq_MCF-7_Human1.74900633
45GABP_19822575_ChIP-Seq_HepG2_Human1.74439738
46VDR_23849224_ChIP-Seq_CD4+_Human1.71495566
47E2F1_18555785_ChIP-Seq_MESCs_Mouse1.69741271
48ZNF263_19887448_ChIP-Seq_K562_Human1.69628495
49SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.66825336
50SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.66825336
51NANOG_21062744_ChIP-ChIP_HESCs_Human1.63982900
52KLF4_18555785_ChIP-Seq_MESCs_Mouse1.63670151
53TRIM28_21343339_ChIP-Seq_HEK293_Human1.57831781
54RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.57783980
55EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.55628395
56DCP1A_22483619_ChIP-Seq_HELA_Human1.54921236
57ELF5_23300383_ChIP-Seq_T47D_Human1.52989875
58POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.52054257
59CDX2_20551321_ChIP-Seq_CACO-2_Human1.51012935
60RUNX1_27514584_Chip-Seq_MCF-7_Human1.50092478
61SOX2_20726797_ChIP-Seq_SW620_Human1.50021204
62GATA3_24758297_ChIP-Seq_MCF-7_Human1.49327844
63KDM5A_27292631_Chip-Seq_BREAST_Human1.48841593
64MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.47319510
65XRN2_22483619_ChIP-Seq_HELA_Human1.46704107
66LXR_22292898_ChIP-Seq_THP-1_Human1.45345306
67PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43427083
68GATA4_25053715_ChIP-Seq_YYC3_Human1.41260109
69TP63_19390658_ChIP-ChIP_HaCaT_Human1.37490368
70GATA6_25053715_ChIP-Seq_YYC3_Human1.37067303
71PPAR_26484153_Chip-Seq_NCI-H1993_Human1.36550429
72TET1_21451524_ChIP-Seq_MESCs_Mouse1.36346380
73TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.35536758
74P63_26484246_Chip-Seq_KERATINOCYTES_Human1.32361395
75KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.31257529
76SRY_22984422_ChIP-ChIP_TESTIS_Rat1.30271941
77CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.30016868
78ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.27030441
79MYC_18940864_ChIP-ChIP_HL60_Human1.26562441
80TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26124013
81TTF2_22483619_ChIP-Seq_HELA_Human1.24403334
82SMC4_20622854_ChIP-Seq_HELA_Human1.23098323
83HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.22717536
84TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.22006336
85* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.21606988
86DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.20183077
87ELF1_17652178_ChIP-ChIP_JURKAT_Human1.19566496
88FOXP3_21729870_ChIP-Seq_TREG_Human1.16866606
89SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.16518102
90ZFX_18555785_ChIP-Seq_MESCs_Mouse1.15725027
91KLF5_25053715_ChIP-Seq_YYC3_Human1.15328701
92STAT3_1855785_ChIP-Seq_MESCs_Mouse1.14942061
93EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.14517637
94YY1_21170310_ChIP-Seq_MESCs_Mouse1.14070041
95RBPJ_22232070_ChIP-Seq_NCS_Mouse1.11979380
96TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11568642
97CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.11089789
98ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.10816599
99E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.10246458
100BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.10045568
101SRF_21415370_ChIP-Seq_HL-1_Mouse1.08186747
102PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.07956722
103YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.05517713
104NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.05445252
105FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.04768293
106ATF3_27146783_Chip-Seq_COLON_Human1.03907894
107SOX2_27498859_Chip-Seq_STOMACH_Mouse1.03798623
108SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.03782059
109TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02686514
110CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.02337265
111CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.01912341
112STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.00145470
113THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.99448142
114ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.98865844
115CIITA_25753668_ChIP-Seq_RAJI_Human0.98234617
116TCF3_18692474_ChIP-Seq_MEFs_Mouse0.97543057
117UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.95800238
118HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.95776048
119HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.95708367
120NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.95553617
121PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.95378684
122P68_20966046_ChIP-Seq_HELA_Human0.95002278
123GATA3_21867929_ChIP-Seq_TH1_Mouse0.94436711
124CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.94244420
125TP63_22573176_ChIP-Seq_HFKS_Human0.94051816
126SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.93972602
127KAP1_27257070_Chip-Seq_ESCs_Mouse0.93512136
128CTCF_18555785_ChIP-Seq_MESCs_Mouse0.93170834
129NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.91494385
130GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90808794
131OCT4_18692474_ChIP-Seq_MEFs_Mouse0.90747957
132SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.89952813
133PPARA_22158963_ChIP-Seq_LIVER_Mouse0.89513058
134RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.87516141
135CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.86692580
136KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.86675607
137HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.84797559
138THAP11_20581084_ChIP-Seq_MESCs_Mouse0.84275629
139SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.82439019
140* SOX17_20123909_ChIP-Seq_XEN_Mouse0.82398972
141TBX5_21415370_ChIP-Seq_HL-1_Mouse0.81688882
142NANOG_18692474_ChIP-Seq_MESCs_Mouse0.81276633
143POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.81068879
144TCF3_18692474_ChIP-Seq_MESCs_Mouse0.80455003
145BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.80425238
146NANOG_18692474_ChIP-Seq_MEFs_Mouse0.79571024
147RBPJ_21746931_ChIP-Seq_IB4_Human0.78963346
148GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.77798488
149PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.77391719
150HOXB4_20404135_ChIP-ChIP_EML_Mouse0.77068381
151FLI1_27457419_Chip-Seq_LIVER_Mouse0.75568264
152CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.74762937
153NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.74390262
154POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.74229553
155SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.72563198
156TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.71924172

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching6.38042412
2MP0003718_maternal_effect5.25589170
3MP0008877_abnormal_DNA_methylation4.25761306
4MP0004957_abnormal_blastocyst_morpholog4.21178938
5MP0003111_abnormal_nucleus_morphology4.11334776
6MP0003646_muscle_fatigue3.96838678
7MP0002796_impaired_skin_barrier3.90444408
8MP0002098_abnormal_vibrissa_morphology3.71724714
9MP0005451_abnormal_body_composition3.40072455
10MP0003077_abnormal_cell_cycle3.28453236
11MP0010094_abnormal_chromosome_stability3.19275134
12MP0005501_abnormal_skin_physiology2.82237535
13MP0008932_abnormal_embryonic_tissue2.64891075
14MP0003123_paternal_imprinting2.57422024
15MP0005395_other_phenotype2.47196492
16MP0002102_abnormal_ear_morphology2.32204738
17MP0000377_abnormal_hair_follicle2.23146717
18MP0001929_abnormal_gametogenesis2.21245719
19MP0003315_abnormal_perineum_morphology2.19969128
20MP0001730_embryonic_growth_arrest2.18823787
21MP0001881_abnormal_mammary_gland2.18221162
22MP0001216_abnormal_epidermal_layer2.16109437
23MP0009840_abnormal_foam_cell2.14968625
24MP0003941_abnormal_skin_development2.14399332
25MP0005076_abnormal_cell_differentiation2.12518619
26MP0002210_abnormal_sex_determination2.04809635
27MP0003699_abnormal_female_reproductive2.01390111
28MP0000653_abnormal_sex_gland2.01065176
29MP0001119_abnormal_female_reproductive1.92869520
30MP0000003_abnormal_adipose_tissue1.92736342
31MP0000516_abnormal_urinary_system1.86144836
32MP0005367_renal/urinary_system_phenotyp1.86144836
33MP0001919_abnormal_reproductive_system1.81481865
34MP0008875_abnormal_xenobiotic_pharmacok1.80675432
35MP0008260_abnormal_autophagy1.73719755
36MP0008058_abnormal_DNA_repair1.73474855
37MP0004233_abnormal_muscle_weight1.73030634
38MP0001145_abnormal_male_reproductive1.70329860
39MP0000537_abnormal_urethra_morphology1.69453954
40MP0005670_abnormal_white_adipose1.69255144
41MP0003937_abnormal_limbs/digits/tail_de1.64804486
42MP0001697_abnormal_embryo_size1.62444214
43MP0005389_reproductive_system_phenotype1.61168621
44MP0000427_abnormal_hair_cycle1.60964012
45MP0008007_abnormal_cellular_replicative1.59069831
46MP0005380_embryogenesis_phenotype1.58492866
47MP0001672_abnormal_embryogenesis/_devel1.58492866
48MP0003566_abnormal_cell_adhesion1.58256469
49MP0010771_integument_phenotype1.57026638
50MP0002085_abnormal_embryonic_tissue1.56100147
51MP0005408_hypopigmentation1.55718912
52MP0000350_abnormal_cell_proliferation1.54306445
53MP0003186_abnormal_redox_activity1.50969384
54MP0001727_abnormal_embryo_implantation1.48321698
55MP0010030_abnormal_orbit_morphology1.48259458
56MP0010352_gastrointestinal_tract_polyps1.44027608
57MP0000762_abnormal_tongue_morphology1.40174230
58MP0009697_abnormal_copulation1.39901767
59MP0003121_genomic_imprinting1.38823707
60MP0002084_abnormal_developmental_patter1.37642868
61MP0000678_abnormal_parathyroid_gland1.35512511
62MP0001346_abnormal_lacrimal_gland1.34840169
63MP0002161_abnormal_fertility/fecundity1.33124664
64MP0002876_abnormal_thyroid_physiology1.32304897
65MP0009780_abnormal_chondrocyte_physiolo1.31956266
66MP0005187_abnormal_penis_morphology1.31911432
67MP0002938_white_spotting1.30997421
68MP0005058_abnormal_lysosome_morphology1.28656819
69MP0002295_abnormal_pulmonary_circulatio1.27321893
70MP0002060_abnormal_skin_morphology1.26524012
71MP0003950_abnormal_plasma_membrane1.25443782
72MP0000579_abnormal_nail_morphology1.25123216
73MP0002086_abnormal_extraembryonic_tissu1.25103697
74MP0002080_prenatal_lethality1.21639596
75MP0005623_abnormal_meninges_morphology1.21056253
76MP0004264_abnormal_extraembryonic_tissu1.18298122
77MP0005646_abnormal_pituitary_gland1.16993296
78MP0000467_abnormal_esophagus_morphology1.16169007
79MP0003984_embryonic_growth_retardation1.16156132
80MP0002088_abnormal_embryonic_growth/wei1.12660971
81MP0004185_abnormal_adipocyte_glucose1.11852479
82MP0002019_abnormal_tumor_incidence1.08740094
83MP0000367_abnormal_coat/_hair1.07976129
84MP0006292_abnormal_olfactory_placode1.03364241
85MP0000383_abnormal_hair_follicle1.01426336
86MP0003698_abnormal_male_reproductive0.98747214
87MP0000462_abnormal_digestive_system0.98356588
88MP0002653_abnormal_ependyma_morphology0.98166074
89MP0002160_abnormal_reproductive_system0.97362634
90MP0003787_abnormal_imprinting0.97161244
91MP0005083_abnormal_biliary_tract0.95332227
92MP0003879_abnormal_hair_cell0.93997157
93MP0009931_abnormal_skin_appearance0.92016332
94MP0010678_abnormal_skin_adnexa0.91679127
95MP0004019_abnormal_vitamin_homeostasis0.89780099
96MP0001661_extended_life_span0.89723319
97MP0005330_cardiomyopathy0.89718511
98MP0000490_abnormal_crypts_of0.89508657
99MP0001756_abnormal_urination0.87435933
100MP0003183_abnormal_peptide_metabolism0.86733197
101MP0000647_abnormal_sebaceous_gland0.86571613
102MP0004381_abnormal_hair_follicle0.86224622
103MP0005375_adipose_tissue_phenotype0.85004214
104MP0000681_abnormal_thyroid_gland0.84409831
105MP0004084_abnormal_cardiac_muscle0.84185489
106MP0000858_altered_metastatic_potential0.82707771
107MP0003221_abnormal_cardiomyocyte_apopto0.82624420
108MP0009333_abnormal_splenocyte_physiolog0.82306405
109MP0003786_premature_aging0.82265023
110MP0005377_hearing/vestibular/ear_phenot0.79546957
111MP0003878_abnormal_ear_physiology0.79546957
112MP0003567_abnormal_fetal_cardiomyocyte0.78691488
113MP0001340_abnormal_eyelid_morphology0.77829624
114MP0000313_abnormal_cell_death0.75158757
115MP0001243_abnormal_dermal_layer0.74208430
116MP0002138_abnormal_hepatobiliary_system0.73242101
117MP0003938_abnormal_ear_development0.72872519
118MP0001851_eye_inflammation0.71029263
119MP0008004_abnormal_stomach_pH0.70829983
120MP0005621_abnormal_cell_physiology0.70585080
121MP0000013_abnormal_adipose_tissue0.70129123
122MP0003119_abnormal_digestive_system0.70023159
123MP0009379_abnormal_foot_pigmentation0.69759241
124MP0002396_abnormal_hematopoietic_system0.69178865
125MP0008057_abnormal_DNA_replication0.68842136
126MP0003045_fibrosis0.68807756
127MP0002249_abnormal_larynx_morphology0.68690675
128MP0001853_heart_inflammation0.68124405
129MP0003329_amyloid_beta_deposits0.68059396
130MP0003705_abnormal_hypodermis_morpholog0.67703039
131MP0000566_synostosis0.67695658
132MP0006035_abnormal_mitochondrial_morpho0.67242707
133MP0005384_cellular_phenotype0.67142068
134MP0009672_abnormal_birth_weight0.65836651
135MP0005023_abnormal_wound_healing0.64965096
136MP0003755_abnormal_palate_morphology0.64568659
137MP0010386_abnormal_urinary_bladder0.64479363
138MP0010234_abnormal_vibrissa_follicle0.64296191
139MP0001915_intracranial_hemorrhage0.63444595
140MP0002697_abnormal_eye_size0.62857455
141MP0003890_abnormal_embryonic-extraembry0.62626892
142MP0002111_abnormal_tail_morphology0.62303293
143MP0000627_abnormal_mammary_gland0.62140703
144MP0000358_abnormal_cell_content/0.62140184
145MP0006072_abnormal_retinal_apoptosis0.61261966
146MP0001666_abnormal_nutrient_absorption0.58538555
147MP0004484_altered_response_of0.58280691
148MP0000613_abnormal_salivary_gland0.57515207
149MP0002168_other_aberrant_phenotype0.57513339
150MP0004947_skin_inflammation0.57083800
151MP0003638_abnormal_response/metabolism_0.56774070
152MP0003936_abnormal_reproductive_system0.56593305
153MP0003942_abnormal_urinary_system0.56353900
154MP0003806_abnormal_nucleotide_metabolis0.56170033
155MP0004133_heterotaxia0.55968258
156MP0003453_abnormal_keratinocyte_physiol0.55459289
157MP0003861_abnormal_nervous_system0.53814516
158MP0004782_abnormal_surfactant_physiolog0.52349500
159MP0003632_abnormal_nervous_system0.51984451
160MP0001849_ear_inflammation0.50961322

Predicted human phenotypes

RankGene SetZ-score
1Breast hypoplasia (HP:0003187)5.98959764
2Right ventricular cardiomyopathy (HP:0011663)5.83471633
3Birth length less than 3rd percentile (HP:0003561)5.48282121
4Premature ovarian failure (HP:0008209)4.70855786
5Carpal bone hypoplasia (HP:0001498)4.50354569
6Patellar aplasia (HP:0006443)4.45019267
7Aplasia/Hypoplasia of the patella (HP:0006498)4.26255668
8Chromsome breakage (HP:0040012)4.26011239
9Secondary amenorrhea (HP:0000869)4.06882417
10Male infertility (HP:0003251)4.05920301
11Hypokinesia (HP:0002375)3.98060698
12Chromosomal breakage induced by crosslinking agents (HP:0003221)3.91166469
13Cervical subluxation (HP:0003308)3.87426355
14Abnormal hair laboratory examination (HP:0003328)3.73097358
15Abnormality of the labia minora (HP:0012880)3.69305647
16Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.64963951
17Absent radius (HP:0003974)3.57900555
18Congenital ichthyosiform erythroderma (HP:0007431)3.43195422
19Hyperthyroidism (HP:0000836)3.42976475
20Amelogenesis imperfecta (HP:0000705)3.41538928
21Lip pit (HP:0100267)3.41527787
22Absent forearm bone (HP:0003953)3.40584288
23Aplasia involving forearm bones (HP:0009822)3.40584288
24Shawl scrotum (HP:0000049)3.33351239
25Woolly hair (HP:0002224)3.23727713
26Aplasia/Hypoplasia of the breasts (HP:0010311)3.23294162
27Aplasia cutis congenita (HP:0001057)3.22599619
28Hypoparathyroidism (HP:0000829)3.17506616
29Breast aplasia (HP:0100783)3.16889403
30Adrenal hypoplasia (HP:0000835)3.14740695
31Micronodular cirrhosis (HP:0001413)3.12862792
32Facial hemangioma (HP:0000329)3.09862123
33Impulsivity (HP:0100710)3.05172863
34Abnormality of the distal phalanges of the toes (HP:0010182)3.04961839
35Capillary hemangiomas (HP:0005306)3.04488296
36Hyperuricemia (HP:0002149)2.99542397
37Increased purine levels (HP:0004368)2.99542397
38Curly hair (HP:0002212)2.99413556
39Oral leukoplakia (HP:0002745)2.98241060
40Fragile nails (HP:0001808)2.95656112
41Aplasia/Hypoplasia involving the musculature (HP:0001460)2.90582527
42Meckel diverticulum (HP:0002245)2.90347439
43Hypotrichosis (HP:0001006)2.86744916
44Abnormal spermatogenesis (HP:0008669)2.82452642
45Proximal tubulopathy (HP:0000114)2.78122528
46Papillary thyroid carcinoma (HP:0002895)2.77134932
47Cortical dysplasia (HP:0002539)2.74623650
48Cerebral hypomyelination (HP:0006808)2.73020419
49Sparse eyelashes (HP:0000653)2.72077840
50Vascular calcification (HP:0004934)2.66145891
51Horseshoe kidney (HP:0000085)2.65349496
52Azoospermia (HP:0000027)2.64353844
53Abnormality of the preputium (HP:0100587)2.63189784
54Abnormality of chromosome stability (HP:0003220)2.62539156
55Trismus (HP:0000211)2.61672913
56Abnormality of the ileum (HP:0001549)2.60831359
57Hypoplastic pelvis (HP:0008839)2.59805891
58Oligodactyly (hands) (HP:0001180)2.59249795
59Abdominal distention (HP:0003270)2.58676882
60Flat capital femoral epiphysis (HP:0003370)2.58100320
61Abnormality of the dental root (HP:0006486)2.56161602
62Taurodontia (HP:0000679)2.56161602
63Abnormality of permanent molar morphology (HP:0011071)2.56161602
64Abnormality of cochlea (HP:0000375)2.52327988
65Hypergonadotropic hypogonadism (HP:0000815)2.49572465
66Abnormality of glycolipid metabolism (HP:0010969)2.49190215
67Abnormality of liposaccharide metabolism (HP:0010968)2.49190215
68Abnormality of glycosphingolipid metabolism (HP:0004343)2.49190215
69Decreased activity of mitochondrial respiratory chain (HP:0008972)2.48366331
70Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.48366331
71Esophageal varix (HP:0002040)2.46951929
72Fibular aplasia (HP:0002990)2.46583584
73Rough bone trabeculation (HP:0100670)2.45260409
74Prolonged neonatal jaundice (HP:0006579)2.44325545
75Distal lower limb muscle weakness (HP:0009053)2.43311547
76Ureteral duplication (HP:0000073)2.42005043
77Truncus arteriosus (HP:0001660)2.40185916
78Selective tooth agenesis (HP:0001592)2.39962200
79Oligodactyly (HP:0012165)2.39303607
80Abnormality of dental color (HP:0011073)2.38959819
81Renal tubular acidosis (HP:0001947)2.37159365
82Seborrheic dermatitis (HP:0001051)2.36919091
83Irregular epiphyses (HP:0010582)2.35601723
84Aplasia/Hypoplasia of the uvula (HP:0010293)2.34560645
85Pulmonary fibrosis (HP:0002206)2.34219280
86Ventricular tachycardia (HP:0004756)2.31989035
87Abnormality of alanine metabolism (HP:0010916)2.30794745
88Hyperalaninemia (HP:0003348)2.30794745
89Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.30794745
90Hyperglycemia (HP:0003074)2.30403105
91Reduced subcutaneous adipose tissue (HP:0003758)2.29154755
92Aplastic anemia (HP:0001915)2.28691565
93Abnormality of molar (HP:0011077)2.28010080
94Abnormality of molar morphology (HP:0011070)2.28010080
95Duodenal stenosis (HP:0100867)2.26628848
96Small intestinal stenosis (HP:0012848)2.26628848
97Bone marrow hypocellularity (HP:0005528)2.24083953
98Megaloblastic anemia (HP:0001889)2.21343005
99Infertility (HP:0000789)2.18491632
100CNS hypomyelination (HP:0003429)2.17505006
101Glomerulosclerosis (HP:0000096)2.17501855
102Diminished movement (HP:0002374)2.16891883
103Patchy hypopigmentation of hair (HP:0011365)2.15422771
104Concave nail (HP:0001598)2.15206894
105Cardiovascular calcification (HP:0011915)2.14758913
106Focal segmental glomerulosclerosis (HP:0000097)2.14186991
107Ankle contracture (HP:0006466)2.13965321
108Ileus (HP:0002595)2.13834298
109Abnormality of the dental pulp (HP:0006479)2.12905684
110Abnormality of the frontal sinuses (HP:0002687)2.09791582
111Aplasia/Hypoplasia of the sternum (HP:0006714)2.08289896
112Aplasia/Hypoplasia of the earlobes (HP:0009906)2.07198433
113Broad face (HP:0000283)2.06039094
114Myelodysplasia (HP:0002863)2.05904986
115White forelock (HP:0002211)2.04784213
116Bell-shaped thorax (HP:0001591)2.04704812
117Abnormality of the proximal phalanges of the hand (HP:0009834)2.02437527
118Abnormal mitochondria in muscle tissue (HP:0008316)2.01355473
119Abnormality of purine metabolism (HP:0004352)2.01023232
120Muscle fiber splitting (HP:0003555)2.00896291
121Abnormal trabecular bone morphology (HP:0100671)2.00526872
122Hypoplasia of the fovea (HP:0007750)2.00239261
123Aplasia/Hypoplasia of the fovea (HP:0008060)2.00239261
124Absent hand (HP:0004050)1.99718910
125Short thumb (HP:0009778)1.99393024
126Personality changes (HP:0000751)1.98826751
127Advanced eruption of teeth (HP:0006288)1.98685385
128Flattened epiphyses (HP:0003071)1.97999024
129Abnormal umbilical cord blood vessels (HP:0011403)1.97907096
130Single umbilical artery (HP:0001195)1.97907096
131Abnormality of the fetal cardiovascular system (HP:0010948)1.97907096
132Fused cervical vertebrae (HP:0002949)1.97274482
133Facial cleft (HP:0002006)1.97196078
134Morphological abnormality of the inner ear (HP:0011390)1.96731617
135Blepharitis (HP:0000498)1.96626587
136Stenosis of the external auditory canal (HP:0000402)1.96482195
137Tracheal stenosis (HP:0002777)1.96364277
138Aplasia/Hypoplasia of the sacrum (HP:0008517)1.94124102
139Type I transferrin isoform profile (HP:0003642)1.93951849
140Sandal gap (HP:0001852)1.93838058
141Rhabdomyosarcoma (HP:0002859)1.91834851
142Overlapping toe (HP:0001845)1.91089358
143Severe short stature (HP:0003510)1.89467566
144Gout (HP:0001997)1.89389874
145Abnormality of methionine metabolism (HP:0010901)1.89387064
146Median cleft lip (HP:0000161)1.88471493
147Villous atrophy (HP:0011473)1.85998003
148Abnormality of small intestinal villus morphology (HP:0011472)1.85998003
149Vacuolated lymphocytes (HP:0001922)1.85367732
150Insulin-resistant diabetes mellitus (HP:0000831)1.84469407
151Flat acetabular roof (HP:0003180)1.84021675
152Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.83932745
153Absent epiphyses (HP:0010577)1.83932745
154Esophageal neoplasm (HP:0100751)1.83306046
155Neoplasm of head and neck (HP:0012288)1.83306046
156Aplasia/Hypoplasia of the ulna (HP:0006495)1.82917281
157Sloping forehead (HP:0000340)1.82678360
158Nail dystrophy (HP:0008404)1.81628956
159Abnormal tarsal ossification (HP:0008369)1.81546166
160Bicornuate uterus (HP:0000813)1.81175247
161Progressive external ophthalmoplegia (HP:0000590)1.80344148
162Triphalangeal thumb (HP:0001199)1.79868928
163Abnormality of nucleobase metabolism (HP:0010932)1.79602871
164Abnormality of the labia (HP:0000058)1.79290209
165Acute myeloid leukemia (HP:0004808)1.77962103
166Abnormality of monocarboxylic acid metabolism (HP:0010996)1.77798842
167Ectopic kidney (HP:0000086)1.77077809
168Increased hepatocellular lipid droplets (HP:0006565)1.76869532
169Abnormality of placental membranes (HP:0011409)1.76797171
170Amniotic constriction ring (HP:0009775)1.76797171
171Abnormality of the fovea (HP:0000493)1.76367284
172Primary amenorrhea (HP:0000786)1.75968717
173Testicular atrophy (HP:0000029)1.75714489
174Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.74784427
175Hypoplasia of the uterus (HP:0000013)1.74480009
176Abnormality of the duodenum (HP:0002246)1.73584814
177Muscle fiber atrophy (HP:0100295)1.73294882
178Abnormality of subcutaneous fat tissue (HP:0001001)1.73186706
179Malnutrition (HP:0004395)1.73138619
180Poor speech (HP:0002465)1.73013179
181Abnormality of the umbilical cord (HP:0010881)1.71846653
182Spontaneous abortion (HP:0005268)1.70852571
183Short clavicles (HP:0000894)1.70469637
184Renal tubular dysfunction (HP:0000124)1.70228116
185Delayed epiphyseal ossification (HP:0002663)1.70133811
186Pili torti (HP:0003777)1.69806555
187Abnormality of the clitoris (HP:0000056)1.69673939
188Sparse lateral eyebrow (HP:0005338)1.67370397
189Tinnitus (HP:0000360)1.66946352

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK44.52358765
2BUB14.50080023
3TTK4.20992096
4EPHA23.92089239
5MST1R3.67583275
6CDK123.53399576
7MST43.31253544
8LATS23.27476558
9WEE13.15833426
10STK38L3.09842314
11BRAF2.89808396
12PNCK2.89071675
13TESK12.82227387
14LATS12.79036333
15NME22.57303712
16MAP3K62.48465315
17PBK2.36045154
18ERBB42.21046853
19SMG12.15532600
20CDC72.14669737
21MAP3K32.14345873
22VRK22.11561680
23MET2.09087575
24NEK21.99599358
25RPS6KB21.99347110
26EEF2K1.90257668
27ACVR1B1.85090712
28ARAF1.78430414
29KSR21.75481675
30PRKD31.70141092
31PLK11.69557415
32CHEK21.63452764
33EIF2AK11.57767962
34MAP3K91.56210217
35TAOK11.54036996
36PTK21.50011519
37MUSK1.43606715
38RAF11.42662345
39MARK11.42439231
40MELK1.32247231
41AURKA1.27891161
42STK31.27530249
43MAP3K81.27501642
44MAPKAPK31.25146899
45STK101.23749262
46DYRK21.19001238
47PLK31.18277011
48NEK11.17319101
49AURKB1.16443242
50SRPK11.15436251
51MAP3K21.13341196
52MYLK1.11057352
53PKN21.07989536
54NTRK11.03920977
55LRRK21.01697227
56KSR11.00594385
57ABL20.99316100
58DYRK30.92665268
59CDK90.92138772
60NLK0.91262440
61SIK10.90329315
62TAOK30.90220372
63PRKCI0.88948762
64NME10.88681174
65MATK0.86345067
66IRAK30.84294827
67STK380.82087543
68DAPK10.80216756
69STK160.79241225
70FER0.79100158
71PAK10.79040473
72PTK60.78767697
73CDK80.77597862
74IRAK20.77165359
75BRSK20.74293871
76MAP2K60.72934599
77EPHB10.71001202
78CAMK2D0.70798552
79CHEK10.69793214
80EIF2AK30.67978168
81ZAK0.65542571
82MAPKAPK50.65048306
83STK390.64652405
84PIK3CA0.64209022
85MOS0.62445249
86STK240.62310519
87TESK20.59836532
88CSNK1G10.58526456
89TSSK60.57735376
90CDK40.56980394
91ICK0.55572469
92BCKDK0.55296355
93DMPK0.54934226
94MAPK150.53442775
95MAPK130.52507403
96DDR20.52453282
97PAK60.52046869
98NEK60.50331031
99FLT30.49937696
100AKT20.47264666
101ERBB20.46709667
102ATM0.46285762
103TYRO30.45527750
104MAP3K130.44786291
105EPHA30.44746094
106BRSK10.43556628
107FGR0.43543421
108CDK20.43119997
109SCYL20.42561053
110EPHB20.42469145
111SIK30.40831554
112IRAK10.37983911
113MAPKAPK20.37775744
114MAP3K50.36452043
115MTOR0.36344066
116CDK10.36115193
117VRK10.34959292
118WNK40.34481635
119RPS6KA40.33666770
120ZAP700.32423954
121ERN10.32263484
122CSNK1E0.32247788
123ILK0.30100811
124JAK30.29814177
125CAMK2G0.27845973
126MAP2K10.27622933
127MAP3K40.27421018
128MAP3K120.27384518
129MAP2K20.25563135
130PAK40.24869227
131TAOK20.24675783
132LIMK10.24405343
133NEK90.24311465
134CSNK1A10.24129698
135CSNK1A1L0.23872251
136FRK0.23842695
137CSNK1G30.22932027
138CDK70.21210665
139PRKCD0.20792691
140CSNK1G20.20275600
141PRKAA10.20092182
142IRAK40.19794855
143SGK20.19756315
144NUAK10.18796021
145TRPM70.18165493
146TRIB30.18023830
147ATR0.17844781
148AKT30.17524720
149CAMK2B0.17127444
150PLK20.15811133
151MAPK100.15423687

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.27722512
2Cell cycle_Homo sapiens_hsa041103.70534660
3Vitamin B6 metabolism_Homo sapiens_hsa007503.61803742
4RNA polymerase_Homo sapiens_hsa030203.47904115
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.30420762
6RNA transport_Homo sapiens_hsa030133.22165131
7Basal transcription factors_Homo sapiens_hsa030223.17124214
8Homologous recombination_Homo sapiens_hsa034402.95950655
9Pentose and glucuronate interconversions_Homo sapiens_hsa000402.77704859
10RNA degradation_Homo sapiens_hsa030182.76441940
11Linoleic acid metabolism_Homo sapiens_hsa005912.45354043
12Fanconi anemia pathway_Homo sapiens_hsa034602.39463893
13Steroid hormone biosynthesis_Homo sapiens_hsa001402.35782420
14Vibrio cholerae infection_Homo sapiens_hsa051102.35668508
15alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.30408662
16DNA replication_Homo sapiens_hsa030302.28573840
17Sulfur relay system_Homo sapiens_hsa041222.17292865
18Nucleotide excision repair_Homo sapiens_hsa034202.14348798
19Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.03983319
20Oocyte meiosis_Homo sapiens_hsa041141.98493034
21Pyrimidine metabolism_Homo sapiens_hsa002401.95826852
22Collecting duct acid secretion_Homo sapiens_hsa049661.95138775
23Base excision repair_Homo sapiens_hsa034101.93722627
24Mismatch repair_Homo sapiens_hsa034301.91892280
25Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.90690547
26Cyanoamino acid metabolism_Homo sapiens_hsa004601.89721312
27Phenylalanine metabolism_Homo sapiens_hsa003601.89107365
28Oxidative phosphorylation_Homo sapiens_hsa001901.84584001
29Regulation of autophagy_Homo sapiens_hsa041401.82350618
30Ether lipid metabolism_Homo sapiens_hsa005651.76977668
31Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.76778074
32Chemical carcinogenesis_Homo sapiens_hsa052041.73618149
33p53 signaling pathway_Homo sapiens_hsa041151.72848752
34Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.70164813
35Spliceosome_Homo sapiens_hsa030401.70112772
36Ovarian steroidogenesis_Homo sapiens_hsa049131.69334624
37Non-homologous end-joining_Homo sapiens_hsa034501.53833182
382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.51413797
39Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.48963046
40Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.48783521
41Fatty acid elongation_Homo sapiens_hsa000621.47234682
42mRNA surveillance pathway_Homo sapiens_hsa030151.45350391
43Circadian rhythm_Homo sapiens_hsa047101.36446664
44Tyrosine metabolism_Homo sapiens_hsa003501.35405605
45Arachidonic acid metabolism_Homo sapiens_hsa005901.29276608
46Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.28750489
47N-Glycan biosynthesis_Homo sapiens_hsa005101.28692643
48Glycerophospholipid metabolism_Homo sapiens_hsa005641.28582961
49Hippo signaling pathway_Homo sapiens_hsa043901.22156267
50Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.21335718
51Purine metabolism_Homo sapiens_hsa002301.21219848
52Pentose phosphate pathway_Homo sapiens_hsa000301.19523616
53Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.13229533
54Starch and sucrose metabolism_Homo sapiens_hsa005001.12421841
55Cysteine and methionine metabolism_Homo sapiens_hsa002701.10648692
56Tight junction_Homo sapiens_hsa045301.10586182
57Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.07447596
58Sulfur metabolism_Homo sapiens_hsa009201.06314535
59Epstein-Barr virus infection_Homo sapiens_hsa051691.06215679
60Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.03980615
61Protein export_Homo sapiens_hsa030601.01016616
62TGF-beta signaling pathway_Homo sapiens_hsa043501.00048986
63Renal cell carcinoma_Homo sapiens_hsa052110.88827612
64Parkinsons disease_Homo sapiens_hsa050120.87819584
65Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.87094822
66MicroRNAs in cancer_Homo sapiens_hsa052060.87092447
67Arginine and proline metabolism_Homo sapiens_hsa003300.86460536
68Shigellosis_Homo sapiens_hsa051310.84570621
69Bladder cancer_Homo sapiens_hsa052190.83479771
70Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.82263262
71One carbon pool by folate_Homo sapiens_hsa006700.81228001
72Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.80696679
73Pancreatic cancer_Homo sapiens_hsa052120.78981384
74Alzheimers disease_Homo sapiens_hsa050100.77369903
75Glutathione metabolism_Homo sapiens_hsa004800.77156025
76Retinol metabolism_Homo sapiens_hsa008300.76868854
77Ribosome_Homo sapiens_hsa030100.75048920
78Sphingolipid metabolism_Homo sapiens_hsa006000.73643025
79Carbon metabolism_Homo sapiens_hsa012000.71704245
80Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.69801884
81Adherens junction_Homo sapiens_hsa045200.69667094
82Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.69446045
83Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.66506346
84Caffeine metabolism_Homo sapiens_hsa002320.65405401
85Other glycan degradation_Homo sapiens_hsa005110.62712568
86Folate biosynthesis_Homo sapiens_hsa007900.61109046
87Hedgehog signaling pathway_Homo sapiens_hsa043400.58601357
88Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.58502831
89Choline metabolism in cancer_Homo sapiens_hsa052310.56754879
90Leukocyte transendothelial migration_Homo sapiens_hsa046700.56646681
91Thyroid cancer_Homo sapiens_hsa052160.56076696
92Colorectal cancer_Homo sapiens_hsa052100.54390984
93Dorso-ventral axis formation_Homo sapiens_hsa043200.53181123
94Endocytosis_Homo sapiens_hsa041440.52872472
95FoxO signaling pathway_Homo sapiens_hsa040680.52458487
96Lysosome_Homo sapiens_hsa041420.50994514
97Basal cell carcinoma_Homo sapiens_hsa052170.50662374
98Hepatitis C_Homo sapiens_hsa051600.50059252
99Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.49659024
100Glycosaminoglycan degradation_Homo sapiens_hsa005310.49655142
101HTLV-I infection_Homo sapiens_hsa051660.49633928
102Fructose and mannose metabolism_Homo sapiens_hsa000510.48239039
103mTOR signaling pathway_Homo sapiens_hsa041500.45908117
104GnRH signaling pathway_Homo sapiens_hsa049120.43143915
105Vitamin digestion and absorption_Homo sapiens_hsa049770.42791560
106Synaptic vesicle cycle_Homo sapiens_hsa047210.42121869
107Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.40467337
108Biosynthesis of amino acids_Homo sapiens_hsa012300.38550263
109Huntingtons disease_Homo sapiens_hsa050160.38250187
110Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.37866795
111Small cell lung cancer_Homo sapiens_hsa052220.37847634
112beta-Alanine metabolism_Homo sapiens_hsa004100.37421982
113Inositol phosphate metabolism_Homo sapiens_hsa005620.36686628
114Longevity regulating pathway - mammal_Homo sapiens_hsa042110.36262119
115Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.36084045
116Regulation of actin cytoskeleton_Homo sapiens_hsa048100.34153854
117Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.33248240
118VEGF signaling pathway_Homo sapiens_hsa043700.33133741
119Prostate cancer_Homo sapiens_hsa052150.33036703
120ECM-receptor interaction_Homo sapiens_hsa045120.31085142
121Viral carcinogenesis_Homo sapiens_hsa052030.29189433
122Peroxisome_Homo sapiens_hsa041460.29152612
123Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.27198323
124Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.26562874
125Prolactin signaling pathway_Homo sapiens_hsa049170.26037008
126Metabolic pathways_Homo sapiens_hsa011000.25298559
127Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.23300398
128Thyroid hormone signaling pathway_Homo sapiens_hsa049190.21619269
129Galactose metabolism_Homo sapiens_hsa000520.21071278
130Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.20231303
131Endometrial cancer_Homo sapiens_hsa052130.18907028
132Pathways in cancer_Homo sapiens_hsa052000.18246388
133Ras signaling pathway_Homo sapiens_hsa040140.17651901
134Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.17570361
135Herpes simplex infection_Homo sapiens_hsa051680.17233153
136Mineral absorption_Homo sapiens_hsa049780.16906134
137Drug metabolism - other enzymes_Homo sapiens_hsa009830.16786798
138Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.16238030
139SNARE interactions in vesicular transport_Homo sapiens_hsa041300.15939135
140Arginine biosynthesis_Homo sapiens_hsa002200.15127799
141Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.13709551
142Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.13375630
143AMPK signaling pathway_Homo sapiens_hsa041520.12617639
144Histidine metabolism_Homo sapiens_hsa003400.11181823
145Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.10083941

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