VGLL4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.85878631
2definitive hemopoiesis (GO:0060216)3.80378264
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.75175380
4antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.75175380
5camera-type eye morphogenesis (GO:0048593)3.58083634
6antigen processing and presentation of endogenous antigen (GO:0019883)3.38736261
7planar cell polarity pathway involved in neural tube closure (GO:0090179)3.33669394
8regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.25403880
9regulation of gamma-delta T cell differentiation (GO:0045586)3.18295827
10ear development (GO:0043583)3.09629246
11neuron projection extension involved in neuron projection guidance (GO:1902284)3.09172800
12axon extension involved in axon guidance (GO:0048846)3.09172800
13positive regulation of gamma-delta T cell activation (GO:0046645)3.08663214
14negative T cell selection (GO:0043383)3.07457910
15negative regulation of catenin import into nucleus (GO:0035414)3.04443907
16regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.03475362
17lymph vessel development (GO:0001945)3.03359420
18regulation of cell proliferation involved in kidney development (GO:1901722)3.02990657
19regulation of T cell tolerance induction (GO:0002664)3.00376210
20semaphorin-plexin signaling pathway (GO:0071526)2.99736879
21G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.97620612
22establishment of tissue polarity (GO:0007164)2.96221857
23establishment of planar polarity (GO:0001736)2.96221857
24negative thymic T cell selection (GO:0045060)2.94740443
25apical protein localization (GO:0045176)2.94283060
26limb bud formation (GO:0060174)2.93152633
27negative regulation of chondrocyte differentiation (GO:0032331)2.87844017
28calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.86913680
29axon ensheathment in central nervous system (GO:0032291)2.84212614
30central nervous system myelination (GO:0022010)2.84212614
31regulation of gamma-delta T cell activation (GO:0046643)2.83945633
32neuron remodeling (GO:0016322)2.83866764
33lung lobe morphogenesis (GO:0060463)2.82265107
34ribosomal small subunit assembly (GO:0000028)2.80673763
35cell proliferation involved in kidney development (GO:0072111)2.78909861
36regulation of somitogenesis (GO:0014807)2.78738844
37vascular endothelial growth factor signaling pathway (GO:0038084)2.78009957
38thymic T cell selection (GO:0045061)2.77565396
39CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.75062390
40angiogenesis involved in wound healing (GO:0060055)2.74118708
41glomerular basement membrane development (GO:0032836)2.72963709
42radial glial cell differentiation (GO:0060019)2.71267365
43platelet dense granule organization (GO:0060155)2.71041463
44Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.69885845
45viral transcription (GO:0019083)2.69149007
46response to laminar fluid shear stress (GO:0034616)2.68640891
47negative regulation of erythrocyte differentiation (GO:0045647)2.68211579
48germ cell migration (GO:0008354)2.68097380
49heart valve formation (GO:0003188)2.67403902
50cell migration in hindbrain (GO:0021535)2.67026609
51regulation of axon extension involved in axon guidance (GO:0048841)2.62406313
52myelination in peripheral nervous system (GO:0022011)2.60974837
53peripheral nervous system axon ensheathment (GO:0032292)2.60974837
54hemidesmosome assembly (GO:0031581)2.60664342
55negative regulation of T-helper cell differentiation (GO:0045623)2.60211369
56negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.60211369
57regulation of extracellular matrix disassembly (GO:0010715)2.59886270
58endothelial cell chemotaxis (GO:0035767)2.59417252
59atrioventricular valve morphogenesis (GO:0003181)2.58602091
60postsynaptic membrane organization (GO:0001941)2.57789839
61antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.57666342
62cellular response to prostaglandin stimulus (GO:0071379)2.56825844
63tolerance induction (GO:0002507)2.54833402
64negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.54815682
65auditory receptor cell differentiation (GO:0042491)2.54470263
66regulation of establishment of planar polarity (GO:0090175)2.54280066
67megakaryocyte development (GO:0035855)2.54082004
68positive thymic T cell selection (GO:0045059)2.53965765
69adhesion of symbiont to host cell (GO:0044650)2.53192226
70virion attachment to host cell (GO:0019062)2.53192226
71positive regulation of astrocyte differentiation (GO:0048711)2.51960285
72glomerular filtration (GO:0003094)2.51208172
73axonal fasciculation (GO:0007413)2.50497047
74neuron recognition (GO:0008038)2.49136223
75ensheathment of neurons (GO:0007272)2.48780892
76axon ensheathment (GO:0008366)2.48780892
77myelination (GO:0042552)2.48675995
78gland morphogenesis (GO:0022612)2.48245239
79lymphoid progenitor cell differentiation (GO:0002320)2.47765246
80mesenchymal cell differentiation involved in renal system development (GO:2001012)2.47749478
81mesenchymal cell differentiation involved in kidney development (GO:0072161)2.47749478
82negative regulation of phagocytosis (GO:0050765)2.46629017
83T cell selection (GO:0045058)2.46543729
84phospholipid scrambling (GO:0017121)2.45280306
85cell-cell junction maintenance (GO:0045217)2.44627875
86embryonic foregut morphogenesis (GO:0048617)2.44397434
87translational termination (GO:0006415)2.44267425
88regulation of cardioblast differentiation (GO:0051890)2.43583858
89metanephric mesenchyme development (GO:0072075)2.43124475
90lens fiber cell development (GO:0070307)2.42473959
91skeletal muscle organ development (GO:0060538)2.41859741
92regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.40502267
93negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.39889994
94ribosomal small subunit biogenesis (GO:0042274)2.39614285
95regulation of axon guidance (GO:1902667)2.39181269
96convergent extension (GO:0060026)2.38579906
97cell differentiation involved in metanephros development (GO:0072202)2.38290817
98response to muramyl dipeptide (GO:0032495)2.38285774
99regulation of tolerance induction (GO:0002643)2.37689558
100cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.36244796
101T cell receptor signaling pathway (GO:0050852)2.36044253
102neuronal stem cell maintenance (GO:0097150)2.34546336
103lung epithelium development (GO:0060428)2.34269393
104germinal center formation (GO:0002467)2.34049658
105appendage development (GO:0048736)2.33563514
106limb development (GO:0060173)2.33563514
107Notch signaling involved in heart development (GO:0061314)2.33442867
108nephron tubule development (GO:0072080)2.33120986
109T-helper cell differentiation (GO:0042093)2.32757786
110CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.32757786
111regulation of isotype switching to IgG isotypes (GO:0048302)2.32635934
112cell proliferation involved in metanephros development (GO:0072203)2.32258056
113regulation of interleukin-12 biosynthetic process (GO:0045075)2.31862278
114interferon-gamma production (GO:0032609)2.30661296
115T cell differentiation (GO:0030217)2.30632614
116positive regulation of tolerance induction (GO:0002645)2.30304718
117negative chemotaxis (GO:0050919)2.30096235
118epithelial cell-cell adhesion (GO:0090136)2.30069039
119mesenchyme morphogenesis (GO:0072132)2.29912243
120pyrimidine nucleobase catabolic process (GO:0006208)2.29911926
121antigen receptor-mediated signaling pathway (GO:0050851)2.29545497
122eye morphogenesis (GO:0048592)2.29371004
123non-canonical Wnt signaling pathway (GO:0035567)2.28787695
124asymmetric protein localization (GO:0008105)2.28223572
125adhesion of symbiont to host (GO:0044406)2.27483383
126metanephric epithelium development (GO:0072207)2.27126124
127cell aggregation (GO:0098743)2.27004888
128cartilage condensation (GO:0001502)2.27004888
129positive regulation of B cell differentiation (GO:0045579)2.26901547
130pattern specification involved in kidney development (GO:0061004)2.26587481
131negative regulation of T cell apoptotic process (GO:0070233)2.26331332
132G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.25407118
133dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.25155648
134regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.24806021
135eye photoreceptor cell differentiation (GO:0001754)2.24334412
136photoreceptor cell differentiation (GO:0046530)2.24334412
137cell junction maintenance (GO:0034331)2.24240898
138regulation of B cell receptor signaling pathway (GO:0050855)2.24120029
139branching involved in salivary gland morphogenesis (GO:0060445)2.23735763
140dendritic spine morphogenesis (GO:0060997)2.23336215
141synapse assembly (GO:0007416)2.23318786
142mast cell activation (GO:0045576)2.22776474
143renal filtration (GO:0097205)2.22752081
144amyloid precursor protein catabolic process (GO:0042987)2.22505120
145glomerulus development (GO:0032835)2.22139328
146left/right pattern formation (GO:0060972)2.22078412
147regulation of T cell receptor signaling pathway (GO:0050856)2.21583861
148paraxial mesoderm development (GO:0048339)2.21346450
149body morphogenesis (GO:0010171)2.21292300
150lateral sprouting from an epithelium (GO:0060601)2.21245954
151positive regulation of mesonephros development (GO:0061213)2.21010955
152muscle organ morphogenesis (GO:0048644)2.20682827
153Notch receptor processing (GO:0007220)2.20661105
154endocardial cushion morphogenesis (GO:0003203)2.20566774
155basement membrane organization (GO:0071711)2.20261429
156cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.19997209
157membrane raft organization (GO:0031579)2.19512220
158bone development (GO:0060348)2.19254777
159secretory granule organization (GO:0033363)2.18292342
160negative regulation of cartilage development (GO:0061037)2.18224291
161cochlea morphogenesis (GO:0090103)2.18186064
162activated T cell proliferation (GO:0050798)2.17305999
163nephron epithelium development (GO:0072009)2.16438996
164NIK/NF-kappaB signaling (GO:0038061)2.16077850
165positive regulation of p38MAPK cascade (GO:1900745)2.15971613
166axon extension (GO:0048675)2.15930564
167embryonic retina morphogenesis in camera-type eye (GO:0060059)2.15593644
168positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.15382267
169leukocyte aggregation (GO:0070486)2.15158695
170negative regulation of protein localization to cell surface (GO:2000009)2.15062593
171establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.15033421
172positive T cell selection (GO:0043368)2.15010583
173heart valve morphogenesis (GO:0003179)2.14155325
174negative regulation of myoblast differentiation (GO:0045662)2.14028873
175blood vessel maturation (GO:0001955)2.13876429
176presynaptic membrane assembly (GO:0097105)2.13755393
177regulation of mesonephros development (GO:0061217)2.13233046
178establishment or maintenance of apical/basal cell polarity (GO:0035088)2.13153620
179establishment or maintenance of bipolar cell polarity (GO:0061245)2.13153620
180positive regulation of smoothened signaling pathway (GO:0045880)2.13095425
181SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.12576266
182cotranslational protein targeting to membrane (GO:0006613)2.12206469
183adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.11587017
184regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.11213461
185protein targeting to ER (GO:0045047)2.11088699
186regulation of interleukin-13 production (GO:0032656)2.10347663
187positive regulation of dendrite morphogenesis (GO:0050775)2.09926824
188positive regulation of gliogenesis (GO:0014015)2.09867969
189establishment or maintenance of monopolar cell polarity (GO:0061339)2.09012619
190establishment of monopolar cell polarity (GO:0061162)2.09012619
191ganglion development (GO:0061548)2.08509799
192nephron tubule formation (GO:0072079)2.08471595
193epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.07058555
194ephrin receptor signaling pathway (GO:0048013)2.06403647

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.90221611
2TP63_17297297_ChIP-ChIP_HaCaT_Human6.00139783
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.34971457
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.59097180
5SCL_19346495_ChIP-Seq_HPC-7_Human3.46898311
6RUNX_20019798_ChIP-Seq_JUKART_Human3.04840636
7EZH2_22144423_ChIP-Seq_EOC_Human2.95873742
8BP1_19119308_ChIP-ChIP_Hs578T_Human2.87393282
9IRF8_22096565_ChIP-ChIP_GC-B_Human2.84460142
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.82162336
11STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.55961051
12ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.50112517
13WT1_19549856_ChIP-ChIP_CCG9911_Human2.48402199
14CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.30490909
15* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.19707891
16* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.19559471
17* IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.18017021
18TRIM28_21343339_ChIP-Seq_HEK293_Human2.16006425
19RBPJ_22232070_ChIP-Seq_NCS_Mouse2.11808595
20EZH2_18974828_ChIP-Seq_MESCs_Mouse2.11162439
21RNF2_18974828_ChIP-Seq_MESCs_Mouse2.11162439
22* RNF2_27304074_Chip-Seq_ESCs_Mouse1.97736199
23EZH2_27304074_Chip-Seq_ESCs_Mouse1.97658462
24NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.94444649
25* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.94421499
26SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.92505125
27* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.91636623
28GATA2_21666600_ChIP-Seq_HMVEC_Human1.90853421
29EED_16625203_ChIP-ChIP_MESCs_Mouse1.90571077
30JARID2_20075857_ChIP-Seq_MESCs_Mouse1.90004666
31* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.89159627
32IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.89074793
33ESR2_21235772_ChIP-Seq_MCF-7_Human1.88016703
34VDR_24763502_ChIP-Seq_THP-1_Human1.87552831
35ESR1_21235772_ChIP-Seq_MCF-7_Human1.84749733
36MAF_26560356_Chip-Seq_TH1_Human1.84114194
37SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.83813921
38SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.82636612
39JARID2_20064375_ChIP-Seq_MESCs_Mouse1.82244474
40* HIF1A_21447827_ChIP-Seq_MCF-7_Human1.81962216
41MYB_26560356_Chip-Seq_TH2_Human1.81324701
42EZH2_27294783_Chip-Seq_ESCs_Mouse1.79930675
43STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.75554899
44SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.75242179
45PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.72689032
46SUZ12_27294783_Chip-Seq_ESCs_Mouse1.72682850
47DROSHA_22980978_ChIP-Seq_HELA_Human1.70542264
48VDR_21846776_ChIP-Seq_THP-1_Human1.69367169
49RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.68688932
50CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.68477469
51SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.68419657
52SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.68147718
53CDX2_20551321_ChIP-Seq_CACO-2_Human1.67428363
54FOXO3_23340844_ChIP-Seq_DLD1_Human1.67384970
55SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.66762088
56RARG_19884340_ChIP-ChIP_MEFs_Mouse1.66754618
57NOTCH1_21737748_ChIP-Seq_TLL_Human1.66643869
58EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.65313117
59SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.64245960
60* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.63145055
61PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.60064308
62SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.59911737
63CLOCK_20551151_ChIP-Seq_293T_Human1.58027103
64SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.57665141
65RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.56580471
66MTF2_20144788_ChIP-Seq_MESCs_Mouse1.54786533
67RING1B_27294783_Chip-Seq_ESCs_Mouse1.53601729
68ELK3_25401928_ChIP-Seq_HUVEC_Human1.53360318
69* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.53214968
70ERG_21242973_ChIP-ChIP_JURKAT_Human1.53038724
71FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.52745560
72TCF7_22412390_ChIP-Seq_EML_Mouse1.51535130
73IRF8_27001747_Chip-Seq_BMDM_Mouse1.51288555
74MYB_26560356_Chip-Seq_TH1_Human1.50814263
75VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.50225481
76NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.48662131
77OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.47626780
78VDR_24787735_ChIP-Seq_THP-1_Human1.47514992
79SOX9_24532713_ChIP-Seq_HFSC_Mouse1.47350816
80ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.47243727
81CBX2_27304074_Chip-Seq_ESCs_Mouse1.46486326
82* KDM2B_26808549_Chip-Seq_K562_Human1.45646917
83IRF8_21731497_ChIP-ChIP_J774_Mouse1.45243743
84THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.44894355
85* ISL1_27105846_Chip-Seq_CPCs_Mouse1.44780723
86* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.44028982
87ZFP281_18757296_ChIP-ChIP_E14_Mouse1.43108068
88* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.43080798
89TP53_20018659_ChIP-ChIP_R1E_Mouse1.42832614
90PPAR_26484153_Chip-Seq_NCI-H1993_Human1.41882321
91AHR_22903824_ChIP-Seq_MCF-7_Human1.41243886
92NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.40499833
93* RING1B_27294783_Chip-Seq_NPCs_Mouse1.39459331
94UTX_26944678_Chip-Seq_JUKART_Human1.38894833
95* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.36323604
96RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.34752181
97* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.34316199
98HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.33850370
99SOX2_20726797_ChIP-Seq_SW620_Human1.32590555
100* RUNX1_22412390_ChIP-Seq_EML_Mouse1.32040672
101KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.31936408
102CDX2_19796622_ChIP-Seq_MESCs_Mouse1.30962239
103SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.30432228
104SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.30432228
105ZFP281_27345836_Chip-Seq_ESCs_Mouse1.27232383
106P63_26484246_Chip-Seq_KERATINOCYTES_Human1.26883151
107LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.22744003
108MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.21594208
109* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.20918001
110ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.17053728
111ESR1_20079471_ChIP-ChIP_T-47D_Human1.16759523
112BRD4_27068464_Chip-Seq_AML-cells_Mouse1.15653667
113KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.15485406
114GATA3_27048872_Chip-Seq_THYMUS_Human1.14807190
115RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.13920243
116ARNT_22903824_ChIP-Seq_MCF-7_Human1.13297772
117CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.12210717
118DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.10754498
119STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.09154699
120ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.09099120
121TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.08885313
122PIAS1_25552417_ChIP-Seq_VCAP_Human1.08154799
123* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.07682277
124STAT6_21828071_ChIP-Seq_BEAS2B_Human1.07205855
125* SPI1_23547873_ChIP-Seq_NB4_Human1.05514091
126PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.05225603
127* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.05132703
128* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.04681433
129NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.04576564
130ELF1_17652178_ChIP-ChIP_JURKAT_Human1.03896954
131ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03703411
132* NFIB_24661679_ChIP-Seq_LUNG_Mouse1.03680017
133GATA2_19941826_ChIP-Seq_K562_Human1.03299938
134MAF_26560356_Chip-Seq_TH2_Human1.03161201
135RUNX1_27514584_Chip-Seq_MCF-7_Human1.03102505
136KDM2B_26808549_Chip-Seq_JURKAT_Human1.03034674
137GATA1_19941826_ChIP-Seq_K562_Human1.02730926
138RACK7_27058665_Chip-Seq_MCF-7_Human1.02029318
139PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.01330228
140CTNNB1_20460455_ChIP-Seq_HCT116_Human1.01138133
141CTCF_27219007_Chip-Seq_Bcells_Human1.00911973
142SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.00848870
143MYC_22102868_ChIP-Seq_BL_Human1.00574261
144KDM2B_26808549_Chip-Seq_DND41_Human1.00445334
145* CJUN_26792858_Chip-Seq_BT549_Human0.99943733
146RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.99713494
147* TP53_23651856_ChIP-Seq_MEFs_Mouse0.99651502
148MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.99366172
149SPI1_23127762_ChIP-Seq_K562_Human0.98926819
150KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.98644851
151UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.96357221
152E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.96327093
153RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.95176200
154RARB_27405468_Chip-Seq_BRAIN_Mouse0.94758406
155WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.94188254
156* TBX20_22080862_ChIP-Seq_HEART_Mouse0.93953491
157* TBX20_22328084_ChIP-Seq_HEART_Mouse0.93953491
158EP300_21415370_ChIP-Seq_HL-1_Mouse0.93681111
159EGR1_19374776_ChIP-ChIP_THP-1_Human0.93086989
160* SMC1_22415368_ChIP-Seq_MEFs_Mouse0.92307896
161AR_21572438_ChIP-Seq_LNCaP_Human0.92250597
162TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.92225425
163CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.91500742
164PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.90617962
165GATA1_22025678_ChIP-Seq_K562_Human0.90075480
166CREB1_26743006_Chip-Seq_LNCaP_Human0.88507161
167TP53_22127205_ChIP-Seq_IMR90_Human0.87977123
168LXR_22292898_ChIP-Seq_THP-1_Human0.87581654
169AR_19668381_ChIP-Seq_PC3_Human0.86437764
170GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.86136008
171DNAJC2_21179169_ChIP-ChIP_NT2_Human0.85548162
172RNF2_27304074_Chip-Seq_NSC_Mouse0.85432083
173KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.85421472
174ESR1_15608294_ChIP-ChIP_MCF-7_Human0.84469345
175MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.83204494
176* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82462511

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010030_abnormal_orbit_morphology2.78680009
2MP0004381_abnormal_hair_follicle2.65556446
3MP0003763_abnormal_thymus_physiology2.53322533
4MP0008438_abnormal_cutaneous_collagen2.49307460
5MP0000685_abnormal_immune_system2.31305837
6MP0004858_abnormal_nervous_system2.29468416
7MP0000383_abnormal_hair_follicle2.22070990
8MP0003724_increased_susceptibility_to2.20972977
9MP0001835_abnormal_antigen_presentation2.15349457
10MP0002166_altered_tumor_susceptibility2.10023036
11MP0000778_abnormal_nervous_system2.07770826
12MP0005257_abnormal_intraocular_pressure2.06304308
13MP0009379_abnormal_foot_pigmentation2.03242990
14MP0002396_abnormal_hematopoietic_system2.01897305
15MP0010368_abnormal_lymphatic_system1.84399315
16MP0010678_abnormal_skin_adnexa1.83811072
17MP0004859_abnormal_synaptic_plasticity1.82921537
18MP0004885_abnormal_endolymph1.81863717
19MP0005671_abnormal_response_to1.79086477
20MP0000465_gastrointestinal_hemorrhage1.75154548
21MP0002653_abnormal_ependyma_morphology1.72686185
22MP0000534_abnormal_ureter_morphology1.71997550
23MP0003705_abnormal_hypodermis_morpholog1.70354597
24MP0002060_abnormal_skin_morphology1.69891626
25MP0001873_stomach_inflammation1.67112561
26MP0005248_abnormal_Harderian_gland1.61717269
27MP0003942_abnormal_urinary_system1.61486371
28MP0009333_abnormal_splenocyte_physiolog1.60965826
29MP0001879_abnormal_lymphatic_vessel1.60048136
30MP0005387_immune_system_phenotype1.58693170
31MP0001790_abnormal_immune_system1.58693170
32MP0003300_gastrointestinal_ulcer1.54163500
33MP0000920_abnormal_myelination1.52220367
34MP0006082_CNS_inflammation1.52113101
35MP0001800_abnormal_humoral_immune1.51731974
36MP0003453_abnormal_keratinocyte_physiol1.48478350
37MP0006054_spinal_hemorrhage1.47991259
38MP0001346_abnormal_lacrimal_gland1.47099023
39MP0000462_abnormal_digestive_system1.46964744
40MP0000049_abnormal_middle_ear1.46825428
41MP0001851_eye_inflammation1.46320826
42MP0002933_joint_inflammation1.45989269
43MP0002254_reproductive_system_inflammat1.44985425
44MP0002009_preneoplasia1.44882174
45MP0003279_aneurysm1.42585700
46MP0001853_heart_inflammation1.41457228
47MP0002420_abnormal_adaptive_immunity1.41256915
48MP0010155_abnormal_intestine_physiology1.40833696
49MP0009384_cardiac_valve_regurgitation1.40780862
50MP0002452_abnormal_antigen_presenting1.40362941
51MP0003122_maternal_imprinting1.40122861
52MP0004272_abnormal_basement_membrane1.40120319
53MP0001502_abnormal_circadian_rhythm1.38752127
54MP0002098_abnormal_vibrissa_morphology1.38315207
55MP0003938_abnormal_ear_development1.38147012
56MP0002249_abnormal_larynx_morphology1.38058200
57MP0001819_abnormal_immune_cell1.37783813
58MP0003385_abnormal_body_wall1.37022997
59MP0002006_tumorigenesis1.35503907
60MP0002233_abnormal_nose_morphology1.34266339
61MP0005000_abnormal_immune_tolerance1.34188755
62MP0000579_abnormal_nail_morphology1.32933514
63MP0002405_respiratory_system_inflammati1.30963008
64MP0009780_abnormal_chondrocyte_physiolo1.30894612
65MP0000762_abnormal_tongue_morphology1.30272305
66MP0001348_abnormal_lacrimal_gland1.30227137
67MP0004947_skin_inflammation1.29169786
68MP0002723_abnormal_immune_serum1.28751390
69MP0005075_abnormal_melanosome_morpholog1.26549490
70MP0005464_abnormal_platelet_physiology1.26053996
71MP0002116_abnormal_craniofacial_bone1.25058006
72MP0005025_abnormal_response_to1.24969718
73MP0005623_abnormal_meninges_morphology1.24381787
74MP0002419_abnormal_innate_immunity1.23749649
75MP0003136_yellow_coat_color1.22616272
76MP0009785_altered_susceptibility_to1.22279432
77MP0000372_irregular_coat_pigmentation1.22082750
78MP0003755_abnormal_palate_morphology1.21085812
79MP0000026_abnormal_inner_ear1.19634379
80MP0003283_abnormal_digestive_organ1.19032109
81MP0003935_abnormal_craniofacial_develop1.17528028
82MP0005394_taste/olfaction_phenotype1.17358338
83MP0005499_abnormal_olfactory_system1.17358338
84MP0002932_abnormal_joint_morphology1.17117291
85MP0002796_impaired_skin_barrier1.17080991
86MP0000377_abnormal_hair_follicle1.16397457
87MP0003119_abnormal_digestive_system1.15964120
88MP0002089_abnormal_postnatal_growth/wei1.15507932
89MP0003115_abnormal_respiratory_system1.15224612
90MP0002697_abnormal_eye_size1.14321776
91MP0005171_absent_coat_pigmentation1.14152848
92MP0005023_abnormal_wound_healing1.14139220
93MP0002398_abnormal_bone_marrow1.12017229
94MP0003878_abnormal_ear_physiology1.11869878
95MP0005377_hearing/vestibular/ear_phenot1.11869878
96MP0005275_abnormal_skin_tensile1.10439953
97MP0002909_abnormal_adrenal_gland1.10351234
98MP0001984_abnormal_olfaction1.10073654
99MP0000716_abnormal_immune_system1.09791167
100MP0009250_abnormal_appendicular_skeleto1.09182483
101MP0009053_abnormal_anal_canal1.08654235
102MP0000767_abnormal_smooth_muscle1.05876688
103MP0005409_darkened_coat_color1.05801244
104MP0002148_abnormal_hypersensitivity_rea1.05739825
105MP0005408_hypopigmentation1.05253056
106MP0003436_decreased_susceptibility_to1.05173788
107MP0008789_abnormal_olfactory_epithelium1.04845232
108MP0000537_abnormal_urethra_morphology1.04061748
109MP0003123_paternal_imprinting1.02429210
110MP0004134_abnormal_chest_morphology1.02339993
111MP0001216_abnormal_epidermal_layer1.01700756
112MP0001849_ear_inflammation1.01625798
113MP0002108_abnormal_muscle_morphology1.01308663
114MP0002896_abnormal_bone_mineralization1.00398940
115MP0000428_abnormal_craniofacial_morphol0.99721554
116MP0003861_abnormal_nervous_system0.99660131
117MP0000703_abnormal_thymus_morphology0.98693048
118MP0009278_abnormal_bone_marrow0.98468970
119MP0002722_abnormal_immune_system0.98051194
120MP0002132_abnormal_respiratory_system0.97843666
121MP0003937_abnormal_limbs/digits/tail_de0.97809947
122MP0001958_emphysema0.97455743
123MP0000955_abnormal_spinal_cord0.97088594
124MP0001243_abnormal_dermal_layer0.95872179
125MP0002282_abnormal_trachea_morphology0.95829810
126MP0001533_abnormal_skeleton_physiology0.95733127
127MP0003329_amyloid_beta_deposits0.95477710
128MP0000689_abnormal_spleen_morphology0.94811112
129MP0000733_abnormal_muscle_development0.93901910
130MP0001270_distended_abdomen0.93688229
131MP0003828_pulmonary_edema0.93168362
132MP0002184_abnormal_innervation0.92290566
133MP0000467_abnormal_esophagus_morphology0.91021963
134MP0000613_abnormal_salivary_gland0.89704244
135MP0000249_abnormal_blood_vessel0.89626730
136MP0002092_abnormal_eye_morphology0.89042636
137MP0002938_white_spotting0.88993048
138MP0001299_abnormal_eye_distance/0.88949314
139MP0005503_abnormal_tendon_morphology0.88710776
140MP0000432_abnormal_head_morphology0.88017378
141MP0002429_abnormal_blood_cell0.87655083
142MP0004808_abnormal_hematopoietic_stem0.87575918
143MP0001545_abnormal_hematopoietic_system0.86566857
144MP0005397_hematopoietic_system_phenotyp0.86566857
145MP0005501_abnormal_skin_physiology0.86216187
146MP0005508_abnormal_skeleton_morphology0.85877409
147MP0003091_abnormal_cell_migration0.83979332
148MP0003690_abnormal_glial_cell0.83703590
149MP0004133_heterotaxia0.83246786
150MP0000566_synostosis0.82899558
151MP0006138_congestive_heart_failure0.82063509
152MP0000647_abnormal_sebaceous_gland0.81821381
153MP0005390_skeleton_phenotype0.81696417
154MP0001286_abnormal_eye_development0.81546681
155MP0003566_abnormal_cell_adhesion0.81308725
156MP0000516_abnormal_urinary_system0.80851181
157MP0005367_renal/urinary_system_phenotyp0.80851181
158MP0004147_increased_porphyrin_level0.80111601
159MP0003191_abnormal_cellular_cholesterol0.79738989
160MP0002152_abnormal_brain_morphology0.79576216
161MP0003634_abnormal_glial_cell0.78484819
162MP0002998_abnormal_bone_remodeling0.78089857
163MP0002557_abnormal_social/conspecific_i0.76876985
164MP0001293_anophthalmia0.76822282
165MP0000013_abnormal_adipose_tissue0.76445251
166MP0002882_abnormal_neuron_morphology0.75730484
167MP0000003_abnormal_adipose_tissue0.74785007
168MP0003121_genomic_imprinting0.73704490
169MP0002063_abnormal_learning/memory/cond0.73039119
170MP0003011_delayed_dark_adaptation0.71890748
171MP0000163_abnormal_cartilage_morphology0.71881704
172MP0001614_abnormal_blood_vessel0.69468367
173MP0002925_abnormal_cardiovascular_devel0.69426712

Predicted human phenotypes

RankGene SetZ-score
1Chronic otitis media (HP:0000389)3.67121577
2Premature skin wrinkling (HP:0100678)3.44395896
3Neonatal short-limb short stature (HP:0008921)3.21551609
4Broad metatarsal (HP:0001783)3.19553241
5Elevated erythrocyte sedimentation rate (HP:0003565)3.08111638
6Patchy hypopigmentation of hair (HP:0011365)3.03228710
7Vertebral arch anomaly (HP:0008438)3.02233118
8Partial duplication of thumb phalanx (HP:0009944)2.98331856
9White forelock (HP:0002211)2.91669823
10Aortic dissection (HP:0002647)2.91008845
11Partial duplication of the phalanx of hand (HP:0009999)2.85620727
12Premature rupture of membranes (HP:0001788)2.84815835
13Bronchomalacia (HP:0002780)2.83409976
14Abnormality of the nasal mucosa (HP:0000433)2.77400792
15Parakeratosis (HP:0001036)2.67231492
16Spontaneous hematomas (HP:0007420)2.64024757
17Bladder diverticulum (HP:0000015)2.63157505
18Agammaglobulinemia (HP:0004432)2.58485256
19Vitreoretinal degeneration (HP:0000655)2.57955661
20Nasal polyposis (HP:0100582)2.57090382
21Atrophic scars (HP:0001075)2.52858820
22Onycholysis (HP:0001806)2.49150959
23Osteolytic defects of the hand bones (HP:0009699)2.47532144
24Osteolytic defects of the phalanges of the hand (HP:0009771)2.47532144
25Asymmetry of the thorax (HP:0001555)2.43735211
26Turricephaly (HP:0000262)2.43437094
27Milia (HP:0001056)2.41820003
28Aplasia involving bones of the extremities (HP:0009825)2.40772926
29Aplasia involving bones of the upper limbs (HP:0009823)2.40772926
30Aplasia of the phalanges of the hand (HP:0009802)2.40772926
31IgM deficiency (HP:0002850)2.40053229
32Hyperacusis (HP:0010780)2.39601064
33Germ cell neoplasia (HP:0100728)2.38312465
34Abnormality of the ischium (HP:0003174)2.36014407
35Abnormal delayed hypersensitivity skin test (HP:0002963)2.35285514
36Myositis (HP:0100614)2.34346885
37Cellulitis (HP:0100658)2.29553007
38Arterial tortuosity (HP:0005116)2.28296647
39Abnormality of dentin (HP:0010299)2.24628018
40Hypoplasia of the iris (HP:0007676)2.24621302
41Hematochezia (HP:0002573)2.22021583
42Ulnar bowing (HP:0003031)2.21920524
43Hypoplastic ischia (HP:0003175)2.20871841
44Thick nail (HP:0001805)2.20184654
45Morphological abnormality of the middle ear (HP:0008609)2.16981318
46Abnormality of the aortic arch (HP:0012303)2.16728600
47Cutaneous finger syndactyly (HP:0010554)2.15984123
48Hepatosplenomegaly (HP:0001433)2.15866300
49Wide anterior fontanel (HP:0000260)2.14504398
50Obstructive sleep apnea (HP:0002870)2.13793386
51Conical tooth (HP:0000698)2.13686276
52Abnormality of the 2nd finger (HP:0004100)2.12180456
53Panhypogammaglobulinemia (HP:0003139)2.11393536
54Renovascular hypertension (HP:0100817)2.07794232
55Vascular tortuosity (HP:0004948)2.06604639
56Inflammation of the large intestine (HP:0002037)2.06324559
57Eosinophilia (HP:0001880)2.05687494
58Disproportionate tall stature (HP:0001519)2.03779803
59Tracheomalacia (HP:0002779)2.02539669
60Aortic aneurysm (HP:0004942)2.00590182
61Abnormality of the phalanges of the 2nd finger (HP:0009541)2.00322925
62Cutaneous syndactyly (HP:0012725)1.99376734
63Abnormality of the parietal bone (HP:0002696)1.98857529
64Recurrent viral infections (HP:0004429)1.98762884
65Soft skin (HP:0000977)1.97372566
66Mitral regurgitation (HP:0001653)1.97233537
67Abnormality of eosinophils (HP:0001879)1.94913820
68Pulmonary embolism (HP:0002204)1.94761113
69Recurrent fungal infections (HP:0002841)1.94181428
70Pustule (HP:0200039)1.93071260
71Aplasia/Hypoplasia of the spleen (HP:0010451)1.91957367
72Ureteral stenosis (HP:0000071)1.91389196
73Abnormal hemoglobin (HP:0011902)1.91249763
74Sprengel anomaly (HP:0000912)1.90371375
75Colitis (HP:0002583)1.90306556
76Overgrowth (HP:0001548)1.89606996
77Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.89410340
78Vertebral hypoplasia (HP:0008417)1.89410340
79Overriding aorta (HP:0002623)1.89248815
80Asplenia (HP:0001746)1.89106209
81Increased IgE level (HP:0003212)1.87814773
82Epiphyseal dysplasia (HP:0002656)1.87433043
83Cervical subluxation (HP:0003308)1.86528986
84Abnormality of incisor morphology (HP:0011063)1.85251548
85Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.85128833
86Short 4th metacarpal (HP:0010044)1.85128833
87Chronic diarrhea (HP:0002028)1.85008543
88Abnormality of the intervertebral disk (HP:0005108)1.84706196
89Bell-shaped thorax (HP:0001591)1.84688389
90Shallow orbits (HP:0000586)1.84400120
91Pulmonary artery stenosis (HP:0004415)1.84059167
92Flat acetabular roof (HP:0003180)1.83022464
93Follicular hyperkeratosis (HP:0007502)1.82972777
94Abnormality of T cell number (HP:0011839)1.82396501
95Recurrent skin infections (HP:0001581)1.82389934
96Chronic mucocutaneous candidiasis (HP:0002728)1.81568659
97Recurrent cutaneous fungal infections (HP:0011370)1.81568659
98Reticulocytopenia (HP:0001896)1.81021569
99Protrusio acetabuli (HP:0003179)1.80367133
100Autoimmune hemolytic anemia (HP:0001890)1.80037841
101Alopecia of scalp (HP:0002293)1.79403767
102Testicular neoplasm (HP:0010788)1.79102666
103Infantile muscular hypotonia (HP:0008947)1.78925447
104Gastrointestinal inflammation (HP:0004386)1.78781152
105Recurrent bronchitis (HP:0002837)1.78639029
106Ectropion (HP:0000656)1.78276795
107Small epiphyses (HP:0010585)1.78115421
108Stomach cancer (HP:0012126)1.77595740
109Ureteral obstruction (HP:0006000)1.77592865
110Prolonged bleeding time (HP:0003010)1.76741334
111Eczematoid dermatitis (HP:0000976)1.76682692
112Abnormality of the dental root (HP:0006486)1.75558355
113Taurodontia (HP:0000679)1.75558355
114Abnormality of permanent molar morphology (HP:0011071)1.75558355
115Megalencephaly (HP:0001355)1.75550964
116Leukocytosis (HP:0001974)1.75233496
117Trigonocephaly (HP:0000243)1.75024765
118Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.74853617
119Abnormality of molar (HP:0011077)1.74426163
120Abnormality of molar morphology (HP:0011070)1.74426163
121T lymphocytopenia (HP:0005403)1.73746216
122Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.73247593
123Ridged nail (HP:0001807)1.73041784
124Abnormality of the diencephalon (HP:0010662)1.72717908
125Aplasia cutis congenita (HP:0001057)1.72602840
126Mitral valve prolapse (HP:0001634)1.71896304
127Spondylolisthesis (HP:0003302)1.71545481
128Cerebral aneurysm (HP:0004944)1.71497243
129Down-sloping shoulders (HP:0200021)1.71042670
130Orchitis (HP:0100796)1.71019299
131Spinal cord lesions (HP:0100561)1.70737326
132Syringomyelia (HP:0003396)1.70737326
133Laryngomalacia (HP:0001601)1.70220201
134Buphthalmos (HP:0000557)1.70148651
135Elfin facies (HP:0004428)1.69190967
136Abnormal ciliary motility (HP:0012262)1.69162731
137Osteoarthritis (HP:0002758)1.68201503
138Anomalous pulmonary venous return (HP:0010772)1.67947400
139Hyperextensible skin (HP:0000974)1.67799567
140Abnormality of T cell physiology (HP:0011840)1.67799222
141Abnormal respiratory epithelium morphology (HP:0012253)1.67552716
142Abnormal respiratory motile cilium morphology (HP:0005938)1.67552716
143Renal duplication (HP:0000075)1.67206585
144Abnormal platelet function (HP:0011869)1.66306999
145Impaired platelet aggregation (HP:0003540)1.66306999
146Abnormality of the distal phalanx of the thumb (HP:0009617)1.66077794
147Atelectasis (HP:0100750)1.65501785
148True hermaphroditism (HP:0010459)1.64001756
149Absent frontal sinuses (HP:0002688)1.63988518
150Coronal craniosynostosis (HP:0004440)1.63926256
151Epistaxis (HP:0000421)1.63793281
152Occipital encephalocele (HP:0002085)1.63686737
153Genetic anticipation (HP:0003743)1.62990573
154Interstitial pulmonary disease (HP:0006530)1.62411759
155Esophageal atresia (HP:0002032)1.62324741
156Broad long bones (HP:0005622)1.60145347
157Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.60001226
158Abnormality of T cells (HP:0002843)1.59769775
159Long toe (HP:0010511)1.59354892
160Absent epiphyses (HP:0010577)1.59084182
161Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.59084182
162Neurofibrillary tangles (HP:0002185)1.58813744
163Meningitis (HP:0001287)1.58735191
164Abnormal foot bone ossification (HP:0010675)1.58383555
165Chin dimple (HP:0010751)1.56491884
166Blue sclerae (HP:0000592)1.56451522
167Abnormality of the 4th metacarpal (HP:0010012)1.56413843
168Hypotrichosis (HP:0001006)1.56041987
169Abnormal respiratory motile cilium physiology (HP:0012261)1.56003719
170Microcytic anemia (HP:0001935)1.55450110
171Gastrointestinal stroma tumor (HP:0100723)1.55427789
172Genu recurvatum (HP:0002816)1.54770963
173Vertebral clefting (HP:0008428)1.54732157
174Flattened epiphyses (HP:0003071)1.54654430
175Hand muscle atrophy (HP:0009130)1.53625487
176Fragile skin (HP:0001030)1.53470478
177Broad phalanx (HP:0006009)1.51356638
178Bowel diverticulosis (HP:0005222)1.50326132
179Congenital glaucoma (HP:0001087)1.50308089
180Alacrima (HP:0000522)1.50129279
181Hallux valgus (HP:0001822)1.48288078

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR23.40696814
2MAP4K13.36619053
3NTRK13.13001559
4EPHA22.77025126
5PRKD32.75928950
6EPHB12.73223984
7TXK2.49396359
8RIPK12.29233256
9CLK12.28662726
10MARK12.16224388
11LATS22.08018487
12EPHA32.05678395
13STK102.03061929
14FGFR41.98402854
15ITK1.97221690
16FGFR21.93076930
17LMTK21.91907400
18PDGFRA1.89977229
19KIT1.79758026
20MAPK151.78795228
21MAP3K141.76847010
22NLK1.75745765
23TYRO31.71221251
24STK391.66537812
25CASK1.61013334
26IKBKE1.55090488
27EEF2K1.53688551
28DDR21.51317072
29MST41.50371148
30CSF1R1.49125848
31BTK1.47129855
32IKBKB1.45991230
33AKT31.44210661
34NTRK21.43515853
35ICK1.40475546
36FER1.38307131
37TIE11.37711404
38TYK21.37424663
39PTK21.35758475
40TEC1.35369325
41SIK11.31094230
42RPS6KA21.29861628
43PIM21.29516244
44TRPM71.27163374
45SGK4941.26812221
46SGK2231.26812221
47CHUK1.24953377
48LRRK21.23326437
49PKN11.18007505
50ZAP701.17543810
51KDR1.16713709
52DMPK1.16355544
53RET1.11703375
54MAP3K71.11093998
55TGFBR11.10403761
56SGK21.09842618
57MARK21.08783418
58FGFR31.08722320
59MTOR1.07997591
60JAK11.07419759
61SMG11.06681444
62MAP2K21.05926465
63NEK61.05768491
64FLT31.05221834
65LCK1.05105628
66MAP3K31.01296359
67CAMK1G0.99018680
68STK38L0.98673558
69TBK10.98005978
70JAK30.95681726
71CDK90.94861544
72PRKD20.94830707
73MAPKAPK30.93390253
74IRAK40.93124444
75PIM10.92202031
76EPHB20.92074517
77CSK0.91417780
78DYRK20.90791512
79HCK0.89830321
80MAP3K100.89208862
81NME20.87456584
82MAP3K40.87333623
83RPS6KB20.87096703
84SIK20.85692726
85MAPK70.84991467
86PAK20.83295142
87PIK3CG0.82913820
88IRAK10.81570962
89MAPKAPK50.81441144
90DYRK1B0.81413822
91ERN10.80392892
92PDGFRB0.80277117
93PIK3CA0.79819304
94MST1R0.78247210
95MAP2K30.76996548
96PTK60.76219673
97STK380.76027258
98SGK30.73431648
99CDK120.72654484
100NUAK10.72096799
101HIPK20.71945243
102MYLK0.71544424
103RPS6KL10.71086548
104RPS6KC10.71086548
105RPS6KA50.70915891
106STK40.69732519
107PKN20.67786899
108CSNK1A1L0.66446559
109ERBB20.66403731
110OXSR10.66329636
111NEK90.65822467
112RPS6KA60.65637167
113CDK190.65369184
114ILK0.65351174
115ROCK10.64159318
116MAP2K70.62526194
117TAOK30.62097827
118NTRK30.61418633
119MET0.60775470
120LYN0.60574670
121PRKD10.60071664
122PRKCQ0.59503722
123MAP3K60.57513008
124MATK0.57143661
125TRIB30.55700778
126MAPKAPK20.54463701
127BLK0.52781042
128BCR0.52326680
129PRKAA20.52247232
130EPHA40.50351140
131FGFR10.49999976
132IGF1R0.49587386
133ROCK20.49205889
134CDK50.49116158
135TNIK0.48795857
136PAK60.48785114
137GRK10.48667399
138GSK3A0.48423920
139GRK70.47318460
140DYRK1A0.46396939
141PRKCH0.46168882
142CAMKK10.46082827
143JAK20.45981041
144CDC42BPA0.45750282
145LATS10.45607523
146MELK0.45211575
147CSNK1G10.44930187
148BMPR1B0.43848366
149IRAK20.43468250
150CSNK1G30.42215038
151CAMK1D0.42111361
152PRKCZ0.42010498
153SRC0.40331185
154LIMK10.40036469
155TESK10.39065017
156ARAF0.37617572
157CSNK1G20.36998915
158KSR10.36984368
159CDK80.35797770
160WNK40.33598244
161MINK10.33557588

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002323.24352876
2Primary immunodeficiency_Homo sapiens_hsa053402.83306045
3Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.35633014
4Hedgehog signaling pathway_Homo sapiens_hsa043401.90899926
5Intestinal immune network for IgA production_Homo sapiens_hsa046721.86472017
6ECM-receptor interaction_Homo sapiens_hsa045121.81280158
7Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.80797849
8Ribosome_Homo sapiens_hsa030101.79840102
9Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.75157318
10T cell receptor signaling pathway_Homo sapiens_hsa046601.72103088
11Fatty acid elongation_Homo sapiens_hsa000621.67195498
12NF-kappa B signaling pathway_Homo sapiens_hsa040641.62440299
13Leukocyte transendothelial migration_Homo sapiens_hsa046701.59698588
14B cell receptor signaling pathway_Homo sapiens_hsa046621.56517125
15Allograft rejection_Homo sapiens_hsa053301.55859449
16Measles_Homo sapiens_hsa051621.52272350
17Hematopoietic cell lineage_Homo sapiens_hsa046401.47873688
18Autoimmune thyroid disease_Homo sapiens_hsa053201.47316172
19Antigen processing and presentation_Homo sapiens_hsa046121.44691883
20Toxoplasmosis_Homo sapiens_hsa051451.44452097
21Tight junction_Homo sapiens_hsa045301.42771941
22Malaria_Homo sapiens_hsa051441.41851408
23Dilated cardiomyopathy_Homo sapiens_hsa054141.41115173
24Osteoclast differentiation_Homo sapiens_hsa043801.36206924
25Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.36029982
26Small cell lung cancer_Homo sapiens_hsa052221.34018409
27Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.32912754
28Chronic myeloid leukemia_Homo sapiens_hsa052201.32896797
29Transcriptional misregulation in cancer_Homo sapiens_hsa052021.31452477
30Leishmaniasis_Homo sapiens_hsa051401.31270817
31Jak-STAT signaling pathway_Homo sapiens_hsa046301.30418193
32Endometrial cancer_Homo sapiens_hsa052131.27964709
33Focal adhesion_Homo sapiens_hsa045101.27191550
34Thyroid hormone signaling pathway_Homo sapiens_hsa049191.26715549
35Melanogenesis_Homo sapiens_hsa049161.26454942
36Notch signaling pathway_Homo sapiens_hsa043301.21356884
37Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.21349908
38Basal cell carcinoma_Homo sapiens_hsa052171.16819183
39Thyroid hormone synthesis_Homo sapiens_hsa049181.12842970
40Acute myeloid leukemia_Homo sapiens_hsa052211.11964993
41Cocaine addiction_Homo sapiens_hsa050301.08193409
42Choline metabolism in cancer_Homo sapiens_hsa052311.07678208
43Platelet activation_Homo sapiens_hsa046111.07522024
44Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.07478720
45Viral myocarditis_Homo sapiens_hsa054161.07262862
46Gap junction_Homo sapiens_hsa045401.06686772
47Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.06442695
48Pancreatic cancer_Homo sapiens_hsa052121.05892156
49Staphylococcus aureus infection_Homo sapiens_hsa051501.04271067
50Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.03513711
51Circadian entrainment_Homo sapiens_hsa047131.03171524
52Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.03005831
53Rap1 signaling pathway_Homo sapiens_hsa040151.02574808
54Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.02311213
55ErbB signaling pathway_Homo sapiens_hsa040121.00933362
56Neurotrophin signaling pathway_Homo sapiens_hsa047221.00205717
57Sphingolipid metabolism_Homo sapiens_hsa006000.99327620
58Phospholipase D signaling pathway_Homo sapiens_hsa040720.99221688
59Wnt signaling pathway_Homo sapiens_hsa043100.97057410
60Graft-versus-host disease_Homo sapiens_hsa053320.96456466
61Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.95788260
62AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.95423630
63Melanoma_Homo sapiens_hsa052180.93261897
64PI3K-Akt signaling pathway_Homo sapiens_hsa041510.93117028
65Cholinergic synapse_Homo sapiens_hsa047250.92589302
66Asthma_Homo sapiens_hsa053100.92510212
67Prostate cancer_Homo sapiens_hsa052150.92203338
68Hepatitis C_Homo sapiens_hsa051600.92168399
69Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.92077216
70Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.91628650
71Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.91474180
72Glutamatergic synapse_Homo sapiens_hsa047240.91194435
73Ras signaling pathway_Homo sapiens_hsa040140.90519627
74Chemical carcinogenesis_Homo sapiens_hsa052040.90501677
75Lysine degradation_Homo sapiens_hsa003100.89426619
76Estrogen signaling pathway_Homo sapiens_hsa049150.88676742
77Phenylalanine metabolism_Homo sapiens_hsa003600.87746558
78Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.87340758
79Steroid biosynthesis_Homo sapiens_hsa001000.87246411
80Pathways in cancer_Homo sapiens_hsa052000.87155146
81Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.86872241
82Shigellosis_Homo sapiens_hsa051310.85385475
83Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.84322869
84MicroRNAs in cancer_Homo sapiens_hsa052060.84261404
85Vascular smooth muscle contraction_Homo sapiens_hsa042700.84013682
86Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.83688056
87Ovarian steroidogenesis_Homo sapiens_hsa049130.83559885
88Hepatitis B_Homo sapiens_hsa051610.82694947
89Thyroid cancer_Homo sapiens_hsa052160.82029848
90Aldosterone synthesis and secretion_Homo sapiens_hsa049250.81082720
91Dopaminergic synapse_Homo sapiens_hsa047280.80986174
92Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.80581717
93Proteoglycans in cancer_Homo sapiens_hsa052050.80383847
94Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.80241014
95Long-term depression_Homo sapiens_hsa047300.79786366
96Dorso-ventral axis formation_Homo sapiens_hsa043200.79529763
97Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.79250344
98VEGF signaling pathway_Homo sapiens_hsa043700.78419891
99AMPK signaling pathway_Homo sapiens_hsa041520.78401774
100Glioma_Homo sapiens_hsa052140.77610034
101HTLV-I infection_Homo sapiens_hsa051660.77242117
102cGMP-PKG signaling pathway_Homo sapiens_hsa040220.76751854
103Bile secretion_Homo sapiens_hsa049760.76742395
104Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.76674907
105Central carbon metabolism in cancer_Homo sapiens_hsa052300.76629752
106Gastric acid secretion_Homo sapiens_hsa049710.76294134
107Adherens junction_Homo sapiens_hsa045200.76068393
108Sulfur metabolism_Homo sapiens_hsa009200.75852135
109Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.75795981
110Apoptosis_Homo sapiens_hsa042100.75455820
111Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.75290824
112Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.74671091
113Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.73594755
114Axon guidance_Homo sapiens_hsa043600.73546566
115Ether lipid metabolism_Homo sapiens_hsa005650.73239884
116TNF signaling pathway_Homo sapiens_hsa046680.72892672
117Glycosaminoglycan degradation_Homo sapiens_hsa005310.72025443
118ABC transporters_Homo sapiens_hsa020100.71816567
119Protein export_Homo sapiens_hsa030600.71583533
120GnRH signaling pathway_Homo sapiens_hsa049120.70839659
121alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.70776485
122cAMP signaling pathway_Homo sapiens_hsa040240.69973703
123Regulation of actin cytoskeleton_Homo sapiens_hsa048100.69635410
124Retinol metabolism_Homo sapiens_hsa008300.68894565
125Longevity regulating pathway - mammal_Homo sapiens_hsa042110.68485983
126Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.68080140
127Circadian rhythm_Homo sapiens_hsa047100.67850716
128Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.67720498
129Fatty acid degradation_Homo sapiens_hsa000710.67533358
130Insulin secretion_Homo sapiens_hsa049110.66634030
131Toll-like receptor signaling pathway_Homo sapiens_hsa046200.66231205
132Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.65393128
133Renin secretion_Homo sapiens_hsa049240.65312365
134TGF-beta signaling pathway_Homo sapiens_hsa043500.64945018
135mTOR signaling pathway_Homo sapiens_hsa041500.64762280
136Insulin signaling pathway_Homo sapiens_hsa049100.64315946
137Pertussis_Homo sapiens_hsa051330.64305309
138Hippo signaling pathway_Homo sapiens_hsa043900.64057781
139Renal cell carcinoma_Homo sapiens_hsa052110.63597471
140Protein digestion and absorption_Homo sapiens_hsa049740.63439560
141Oxytocin signaling pathway_Homo sapiens_hsa049210.63212243
142Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.62904797
143Salivary secretion_Homo sapiens_hsa049700.62887331
144Bladder cancer_Homo sapiens_hsa052190.62809429
145Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.62644811
146Chemokine signaling pathway_Homo sapiens_hsa040620.62589699
147Inositol phosphate metabolism_Homo sapiens_hsa005620.62462579
148RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.62456015
149Serotonergic synapse_Homo sapiens_hsa047260.61346458
150Histidine metabolism_Homo sapiens_hsa003400.61051563
151Herpes simplex infection_Homo sapiens_hsa051680.60980287
152NOD-like receptor signaling pathway_Homo sapiens_hsa046210.60763250
153Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.59926477
154Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.59315419
155beta-Alanine metabolism_Homo sapiens_hsa004100.59233029
156Arachidonic acid metabolism_Homo sapiens_hsa005900.59187337
157Colorectal cancer_Homo sapiens_hsa052100.58544628
158Sphingolipid signaling pathway_Homo sapiens_hsa040710.58405080
159Other glycan degradation_Homo sapiens_hsa005110.57979596
160Fatty acid metabolism_Homo sapiens_hsa012120.57786577
161Phosphatidylinositol signaling system_Homo sapiens_hsa040700.56951920
162Amphetamine addiction_Homo sapiens_hsa050310.56653504
163MAPK signaling pathway_Homo sapiens_hsa040100.56548579
164Prion diseases_Homo sapiens_hsa050200.56387689
165Amoebiasis_Homo sapiens_hsa051460.55343483
166Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.54368380
167PPAR signaling pathway_Homo sapiens_hsa033200.53098942

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