VILL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the villin/gelsolin family. It contains 6 gelsolin-like repeats and a headpiece domain. It may play a role in actin-bundling. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1aminoglycoside antibiotic metabolic process (GO:0030647)5.96465795
2daunorubicin metabolic process (GO:0044597)5.93246876
3polyketide metabolic process (GO:0030638)5.93246876
4doxorubicin metabolic process (GO:0044598)5.93246876
5antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.48366895
6antigen processing and presentation of endogenous antigen (GO:0019883)5.47580609
7antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.30248400
8angiotensin maturation (GO:0002003)5.26563222
9ribosomal small subunit assembly (GO:0000028)4.89744976
10negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.34141483
11negative regulation of cell killing (GO:0031342)4.34141483
12negative regulation of epidermis development (GO:0045683)4.32192871
13regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.28825800
14regulation of cellular extravasation (GO:0002691)4.03784412
15formation of translation preinitiation complex (GO:0001731)4.03483818
16positive regulation of gamma-delta T cell activation (GO:0046645)3.99561768
17ribosomal small subunit biogenesis (GO:0042274)3.96908063
18regulation of guanylate cyclase activity (GO:0031282)3.90917532
19negative regulation of epidermal cell differentiation (GO:0045605)3.87653387
20protein localization to kinetochore (GO:0034501)3.85551467
21axonemal dynein complex assembly (GO:0070286)3.84251504
22viral transcription (GO:0019083)3.77915562
23detection of bacterium (GO:0016045)3.73891022
24translational termination (GO:0006415)3.61543920
25detection of other organism (GO:0098543)3.61228915
26pentose-phosphate shunt (GO:0006098)3.60149049
27regulation of mammary gland epithelial cell proliferation (GO:0033599)3.54865051
28regulation of apoptotic process involved in morphogenesis (GO:1902337)3.53527785
29tolerance induction (GO:0002507)3.48883048
30maintenance of gastrointestinal epithelium (GO:0030277)3.47332070
31regulation of gamma-delta T cell differentiation (GO:0045586)3.44890588
32intestinal absorption (GO:0050892)3.43152707
33peptide catabolic process (GO:0043171)3.40823272
34cilium or flagellum-dependent cell motility (GO:0001539)3.38130217
35NADH metabolic process (GO:0006734)3.37810616
36regulation of gamma-delta T cell activation (GO:0046643)3.37113286
37regulation of nuclear cell cycle DNA replication (GO:0033262)3.35785678
38vitamin transmembrane transport (GO:0035461)3.35381457
39negative regulation of phagocytosis (GO:0050765)3.34678294
40negative regulation of cell cycle G2/M phase transition (GO:1902750)3.31160875
41lipoprotein transport (GO:0042953)3.30404749
42diterpenoid biosynthetic process (GO:0016102)3.22383435
43regulation of dendritic cell antigen processing and presentation (GO:0002604)3.21359689
44SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.18285696
45positive regulation of Cdc42 GTPase activity (GO:0043089)3.18151622
46regulation of response to osmotic stress (GO:0047484)3.18029854
47regulation of tolerance induction (GO:0002643)3.17697523
48positive regulation of tolerance induction (GO:0002645)3.17678033
49translational elongation (GO:0006414)3.17192406
50negative regulation of erythrocyte differentiation (GO:0045647)3.15818682
51antimicrobial humoral response (GO:0019730)3.14025297
52fat-soluble vitamin biosynthetic process (GO:0042362)3.13448088
53NADPH regeneration (GO:0006740)3.13108499
54positive thymic T cell selection (GO:0045059)3.12969428
55epoxygenase P450 pathway (GO:0019373)3.12589271
56maturation of SSU-rRNA (GO:0030490)3.11908341
57antibacterial humoral response (GO:0019731)3.11781327
58protein targeting to ER (GO:0045047)3.07619598
59cotranslational protein targeting to membrane (GO:0006613)3.07555097
60ethanol oxidation (GO:0006069)3.07454674
61muscle organ morphogenesis (GO:0048644)3.07397463
62response to interferon-beta (GO:0035456)3.07135990
63antigen processing and presentation via MHC class Ib (GO:0002475)3.06514112
64diacylglycerol metabolic process (GO:0046339)3.06442461
65negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.00675238
66positive regulation of respiratory burst (GO:0060267)2.99726991
67O-glycan processing (GO:0016266)2.94185608
68ethanol metabolic process (GO:0006067)2.93839598
69nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.90781796
70establishment of protein localization to endoplasmic reticulum (GO:0072599)2.89954419
71phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.89501775
72telomere maintenance via semi-conservative replication (GO:0032201)2.88319911
73DNA deamination (GO:0045006)2.88293172
74definitive hemopoiesis (GO:0060216)2.86695650
75regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.85965515
76endocrine process (GO:0050886)2.85965515
77regulation of systemic arterial blood pressure by hormone (GO:0001990)2.85965515
78protein localization to endoplasmic reticulum (GO:0070972)2.84892802
79DNA replication initiation (GO:0006270)2.83957860
80DNA unwinding involved in DNA replication (GO:0006268)2.83887606
81viral life cycle (GO:0019058)2.83230319
82negative thymic T cell selection (GO:0045060)2.82408828
83motile cilium assembly (GO:0044458)2.81506387
84regulation of vitamin metabolic process (GO:0030656)2.81317129
85DNA strand elongation involved in DNA replication (GO:0006271)2.80610023
86leukotriene metabolic process (GO:0006691)2.79518563
87pentose metabolic process (GO:0019321)2.79336903
88DNA replication checkpoint (GO:0000076)2.79286608
89protein localization to chromosome, centromeric region (GO:0071459)2.79010276
90glycoside metabolic process (GO:0016137)2.78900878
91negative regulation of lymphocyte mediated immunity (GO:0002707)2.78509295
92B cell mediated immunity (GO:0019724)2.77894290
93regulation of B cell receptor signaling pathway (GO:0050855)2.77502832
94ribonucleoprotein complex biogenesis (GO:0022613)2.76359901
95GDP-mannose metabolic process (GO:0019673)2.74763869
96regulation of respiratory burst (GO:0060263)2.74741489
97positive regulation of DNA-dependent DNA replication (GO:2000105)2.74216116
98translational initiation (GO:0006413)2.73051739
99pseudouridine synthesis (GO:0001522)2.72295936
100valine metabolic process (GO:0006573)2.71842349
101B cell receptor signaling pathway (GO:0050853)2.70985463
102receptor guanylyl cyclase signaling pathway (GO:0007168)2.70708385
103response to peptidoglycan (GO:0032494)2.70624028
104interferon-gamma secretion (GO:0072643)2.70454073
105hormone catabolic process (GO:0042447)2.70075326
106response to type I interferon (GO:0034340)2.68937726
107ribosome biogenesis (GO:0042254)2.68318194
108germinal center formation (GO:0002467)2.68047248
109DNA strand elongation (GO:0022616)2.67858939
110immunoglobulin mediated immune response (GO:0016064)2.67509560
111interferon-gamma-mediated signaling pathway (GO:0060333)2.67228494
112rRNA transcription (GO:0009303)2.67079815
113cellular response to type I interferon (GO:0071357)2.66362552
114type I interferon signaling pathway (GO:0060337)2.66362552
115negative T cell selection (GO:0043383)2.65976187
116thymic T cell selection (GO:0045061)2.65620351
117positive regulation by organism of defense response of other organism involved in symbiotic interact2.65382802
118modulation by symbiont of host immune response (GO:0052553)2.65382802
119positive regulation by symbiont of host defense response (GO:0052509)2.65382802
120modulation by symbiont of host defense response (GO:0052031)2.65382802
121modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.65382802
122modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.65382802
123positive regulation of pseudopodium assembly (GO:0031274)2.63432572
124response to interferon-alpha (GO:0035455)2.62215878
125positive regulation of antigen processing and presentation (GO:0002579)2.62005586
126regulation of translation in response to stress (GO:0043555)2.61967240
127antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.61410782
128T cell selection (GO:0045058)2.61399228
129epithelial structure maintenance (GO:0010669)2.61312597
130positive regulation of protein import into nucleus, translocation (GO:0033160)2.61258956
131cellular protein complex disassembly (GO:0043624)2.61167842
132regulation of antigen processing and presentation (GO:0002577)2.61114562
133positive regulation of guanylate cyclase activity (GO:0031284)2.60603692
134regulation of telomere maintenance via telomerase (GO:0032210)2.58900016
135negative regulation of leukocyte mediated immunity (GO:0002704)2.57013640
136negative regulation of toll-like receptor signaling pathway (GO:0034122)2.56144331
137dendritic cell chemotaxis (GO:0002407)2.53952543
138phospholipid scrambling (GO:0017121)2.53836857
139negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.53091359
140NIK/NF-kappaB signaling (GO:0038061)2.51564840
141positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.51443687
142heterochromatin organization (GO:0070828)2.51330851
143positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.50513090
144positive regulation of B cell differentiation (GO:0045579)2.49676467
145regulation of systemic arterial blood pressure (GO:0003073)2.47503868
146oligosaccharide biosynthetic process (GO:0009312)2.47478386
147detection of external biotic stimulus (GO:0098581)2.46997061
148neutrophil activation involved in immune response (GO:0002283)2.46777502
149positive T cell selection (GO:0043368)2.46514545
150regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.46427860
151regulation of T cell tolerance induction (GO:0002664)2.44759343
152primary alcohol catabolic process (GO:0034310)2.43781472
153regulation of necrotic cell death (GO:0010939)2.42989701
154glucose catabolic process (GO:0006007)2.42190553
155megakaryocyte development (GO:0035855)2.41875336
156negative regulation of telomerase activity (GO:0051974)2.41474834
157DNA duplex unwinding (GO:0032508)2.39403736
158protein complex disassembly (GO:0043241)2.39192018
159DNA geometric change (GO:0032392)2.38078802
160regulation of interferon-beta biosynthetic process (GO:0045357)2.37017195
161DNA replication-dependent nucleosome assembly (GO:0006335)2.36984835
162DNA replication-dependent nucleosome organization (GO:0034723)2.36984835
163sperm capacitation (GO:0048240)2.36619828
164regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.36604031
165mannose metabolic process (GO:0006013)2.36597222
166glomerular filtration (GO:0003094)2.36046338
167toxin transport (GO:1901998)2.35861637
168mitotic sister chromatid segregation (GO:0000070)2.35195484
169glycosphingolipid catabolic process (GO:0046479)2.35120358
170organic cation transport (GO:0015695)2.34945792
171maintenance of protein location in nucleus (GO:0051457)2.34906734
172macrophage activation involved in immune response (GO:0002281)2.34853994
173negative regulation of myotube differentiation (GO:0010832)2.34324997
174drug metabolic process (GO:0017144)2.33603167
175telomere maintenance via recombination (GO:0000722)2.33317076
176positive regulation of defense response to virus by host (GO:0002230)2.31347167
177histone H4-K12 acetylation (GO:0043983)2.30808348
178lymphoid progenitor cell differentiation (GO:0002320)2.29543286
179cytidine catabolic process (GO:0006216)2.28567956
180cytidine deamination (GO:0009972)2.28567956
181cytidine metabolic process (GO:0046087)2.28567956
182response to protozoan (GO:0001562)2.27331999
183somite rostral/caudal axis specification (GO:0032525)2.26615381
184vitamin A metabolic process (GO:0006776)2.26149639
185melanosome organization (GO:0032438)2.25659332
186primitive streak formation (GO:0090009)2.25168521
187rRNA modification (GO:0000154)2.24895050
188endosome to melanosome transport (GO:0035646)2.24866581
189endosome to pigment granule transport (GO:0043485)2.24866581
190negative regulation of telomere maintenance (GO:0032205)2.23637773
191regulation of MHC class I biosynthetic process (GO:0045343)2.23615103
192hypotonic response (GO:0006971)2.23391971
193pigment granule organization (GO:0048753)2.21846370
194mitotic recombination (GO:0006312)2.21815669
195DNA damage response, detection of DNA damage (GO:0042769)2.21242073

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.25233055
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.68242879
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.29856171
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.02877408
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.91519127
6KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.86323664
7KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.86323664
8KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.86323664
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.85839236
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.41240194
11SCL_19346495_ChIP-Seq_HPC-7_Human2.28574317
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.25379124
13FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.15931044
14* LXR_22292898_ChIP-Seq_THP-1_Human2.13704667
15FOXM1_23109430_ChIP-Seq_U2OS_Human2.10180668
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.01399556
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.00295129
18POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.98063351
19SOX2_27498859_Chip-Seq_STOMACH_Mouse1.97209069
20THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.95996242
21VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.91854132
22MYC_19079543_ChIP-ChIP_MESCs_Mouse1.90360837
23MYC_18358816_ChIP-ChIP_MESCs_Mouse1.90327978
24E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.89738835
25KDM2B_26808549_Chip-Seq_SUP-B15_Human1.87876396
26SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.86568855
27RUNX_20019798_ChIP-Seq_JUKART_Human1.81351805
28MYC_19030024_ChIP-ChIP_MESCs_Mouse1.79907488
29MYC_22102868_ChIP-Seq_BL_Human1.79829733
30IRF8_27001747_Chip-Seq_BMDM_Mouse1.78979611
31* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.75980388
32RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.75363924
33NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.74193213
34EGR1_19374776_ChIP-ChIP_THP-1_Human1.71623621
35TP63_19390658_ChIP-ChIP_HaCaT_Human1.69745873
36IRF8_22096565_ChIP-ChIP_GC-B_Human1.69540457
37MYB_21317192_ChIP-Seq_ERMYB_Mouse1.67609595
38STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.66198585
39TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.66028837
40RACK7_27058665_Chip-Seq_MCF-7_Human1.62491527
41MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.62187411
42SPI1_23127762_ChIP-Seq_K562_Human1.60972355
43VDR_21846776_ChIP-Seq_THP-1_Human1.58033659
44DROSHA_22980978_ChIP-Seq_HELA_Human1.57215393
45UTX_26944678_Chip-Seq_JUKART_Human1.57134485
46KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.56876993
47FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.55680822
48* GATA1_19941826_ChIP-Seq_K562_Human1.54164309
49ELF1_17652178_ChIP-ChIP_JURKAT_Human1.51988289
50PPARA_22158963_ChIP-Seq_LIVER_Mouse1.51824054
51NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.51456537
52IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.51261694
53* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.50984434
54FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.50155491
55* SPI1_23547873_ChIP-Seq_NB4_Human1.49125015
56RARG_19884340_ChIP-ChIP_MEFs_Mouse1.46515531
57RXR_22158963_ChIP-Seq_LIVER_Mouse1.45650099
58KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.45160248
59SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.44717820
60TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.44437477
61ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.42543161
62NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.42358924
63BCL6_27268052_Chip-Seq_Bcells_Human1.42291256
64TP63_17297297_ChIP-ChIP_HaCaT_Human1.42214609
65NANOG_18555785_ChIP-Seq_MESCs_Mouse1.41508090
66E2F1_18555785_ChIP-Seq_MESCs_Mouse1.40444454
67GATA6_25053715_ChIP-Seq_YYC3_Human1.39620883
68PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.39245338
69EST1_17652178_ChIP-ChIP_JURKAT_Human1.39193979
70AR_21909140_ChIP-Seq_LNCAP_Human1.39163039
71KDM2B_26808549_Chip-Seq_DND41_Human1.38623785
72CREB1_15753290_ChIP-ChIP_HEK293T_Human1.38047480
73RUNX1_27514584_Chip-Seq_MCF-7_Human1.36941250
74* BCOR_27268052_Chip-Seq_Bcells_Human1.36244958
75IRF8_21731497_ChIP-ChIP_J774_Mouse1.34583477
76GATA1_19941827_ChIP-Seq_MEL_Mouse1.33408046
77TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.33091930
78TCF3_18692474_ChIP-Seq_MEFs_Mouse1.33074858
79ESR2_21235772_ChIP-Seq_MCF-7_Human1.32853432
80* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.32081702
81STAT4_19710469_ChIP-ChIP_TH1__Mouse1.31976324
82CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.31821251
83SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.30951766
84CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.30016145
85HIF1A_21447827_ChIP-Seq_MCF-7_Human1.29834495
86* GATA4_25053715_ChIP-Seq_YYC3_Human1.29732221
87MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.29654808
88NELFA_20434984_ChIP-Seq_ESCs_Mouse1.28943429
89XRN2_22483619_ChIP-Seq_HELA_Human1.28043027
90PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.27895113
91P63_26484246_Chip-Seq_KERATINOCYTES_Human1.27207582
92JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.27161045
93KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.26667349
94TCF7_22412390_ChIP-Seq_EML_Mouse1.25965006
95ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.25933074
96FOXO3_23340844_ChIP-Seq_DLD1_Human1.25590387
97* RUNX1_22412390_ChIP-Seq_EML_Mouse1.25475395
98* GATA2_19941826_ChIP-Seq_K562_Human1.25179664
99CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.23853219
100* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.23566866
101CDX2_20551321_ChIP-Seq_CACO-2_Human1.23314369
102MAF_26560356_Chip-Seq_TH2_Human1.23074553
103SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.22990776
104CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.22819606
105SOX2_20726797_ChIP-Seq_SW620_Human1.22670822
106GATA1_22025678_ChIP-Seq_K562_Human1.21876942
107ETS1_20019798_ChIP-Seq_JURKAT_Human1.21355304
108* ELK3_25401928_ChIP-Seq_HUVEC_Human1.21284538
109MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.21270517
110BRD4_27068464_Chip-Seq_AML-cells_Mouse1.20863284
111CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20721107
112ERG_20887958_ChIP-Seq_HPC-7_Mouse1.20461409
113MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.20077037
114VDR_24787735_ChIP-Seq_THP-1_Human1.19287667
115PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19247649
116TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.18994021
117GABP_17652178_ChIP-ChIP_JURKAT_Human1.17812775
118GATA2_22383799_ChIP-Seq_G1ME_Mouse1.17515061
119NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.16985947
120ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.16621995
121SA1_27219007_Chip-Seq_ERYTHROID_Human1.16249954
122P68_20966046_ChIP-Seq_HELA_Human1.15083539
123LXR_22158963_ChIP-Seq_LIVER_Mouse1.14979787
124FOXP3_21729870_ChIP-Seq_TREG_Human1.14801447
125CTCF_27219007_Chip-Seq_ERYTHROID_Human1.14497363
126GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.14465834
127NOTCH1_21737748_ChIP-Seq_TLL_Human1.14292725
128ESR1_21235772_ChIP-Seq_MCF-7_Human1.14123462
129FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.13117833
130SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.12729048
131SMC4_20622854_ChIP-Seq_HELA_Human1.11416742
132POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.11145005
133SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.10893806
134YY1_21170310_ChIP-Seq_MESCs_Mouse1.10596532
135GATA3_27048872_Chip-Seq_THYMUS_Human1.10471111
136KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.10195107
137SA1_27219007_Chip-Seq_Bcells_Human1.10032440
138TFEB_21752829_ChIP-Seq_HELA_Human1.09678882
139BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.09605707
140ESR1_15608294_ChIP-ChIP_MCF-7_Human1.09446708
141GATA2_21666600_ChIP-Seq_HMVEC_Human1.09413418
142STAT1_20625510_ChIP-Seq_HELA_Human1.08832573
143HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.07836460
144TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.07534771
145NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.07376749
146MAF_26560356_Chip-Seq_TH1_Human1.07202790
147GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07132749
148HOXB4_20404135_ChIP-ChIP_EML_Mouse1.07090230
149VDR_23849224_ChIP-Seq_CD4+_Human1.05888495
150KLF5_25053715_ChIP-Seq_YYC3_Human1.05712799
151NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.04891410
152GATA1_22383799_ChIP-Seq_G1ME_Mouse1.04494588
153RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02979872
154* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.02952378
155* NCOR1_26117541_ChIP-Seq_K562_Human1.00876285
156ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.00120880
157NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.99889836
158LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.98879083
159DCP1A_22483619_ChIP-Seq_HELA_Human0.98860058
160SOX2_18692474_ChIP-Seq_MEFs_Mouse0.97252162
161OCT4_18692474_ChIP-Seq_MEFs_Mouse0.96852391
162MYB_26560356_Chip-Seq_TH1_Human0.96756064
163TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96557698
164GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.96076117
165VDR_24763502_ChIP-Seq_THP-1_Human0.95643685
166MYB_26560356_Chip-Seq_TH2_Human0.95553815
167RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.95087091
168KLF4_18555785_ChIP-Seq_MESCs_Mouse0.95011668
169GABP_19822575_ChIP-Seq_HepG2_Human0.94041998
170POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.93989481
171STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.93979797
172SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.93576710

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis3.95684769
2MP0004264_abnormal_extraembryonic_tissu3.09396277
3MP0003303_peritoneal_inflammation2.85513195
4MP0008004_abnormal_stomach_pH2.84626302
5MP0002396_abnormal_hematopoietic_system2.81510788
6MP0003866_abnormal_defecation2.72049647
7MP0005075_abnormal_melanosome_morpholog2.65846471
8MP0002139_abnormal_hepatobiliary_system2.60531862
9MP0004957_abnormal_blastocyst_morpholog2.40791167
10MP0000490_abnormal_crypts_of2.32791463
11MP0001666_abnormal_nutrient_absorption2.28159535
12MP0010352_gastrointestinal_tract_polyps2.22572473
13MP0001790_abnormal_immune_system2.21117566
14MP0005387_immune_system_phenotype2.21117566
15MP0010234_abnormal_vibrissa_follicle2.10395624
16MP0009379_abnormal_foot_pigmentation2.08391660
17MP0005085_abnormal_gallbladder_physiolo2.06728051
18MP0003763_abnormal_thymus_physiology2.02942947
19MP0006292_abnormal_olfactory_placode1.95269131
20MP0003436_decreased_susceptibility_to1.87563875
21MP0005671_abnormal_response_to1.86844088
22MP0003300_gastrointestinal_ulcer1.85920001
23MP0003011_delayed_dark_adaptation1.84876058
24MP0001835_abnormal_antigen_presentation1.82796918
25MP0005365_abnormal_bile_salt1.82101951
26MP0009840_abnormal_foam_cell1.80482104
27MP0004808_abnormal_hematopoietic_stem1.78423253
28MP0004947_skin_inflammation1.76435673
29MP0003693_abnormal_embryo_hatching1.70113674
30MP0001663_abnormal_digestive_system1.66454661
31MP0003186_abnormal_redox_activity1.64653806
32MP0009785_altered_susceptibility_to1.64486623
33MP0003077_abnormal_cell_cycle1.64289593
34MP0005166_decreased_susceptibility_to1.61631966
35MP0004043_abnormal_pH_regulation1.59204877
36MP0003191_abnormal_cellular_cholesterol1.58432026
37MP0001765_abnormal_ion_homeostasis1.56452929
38MP0001664_abnormal_digestion1.55997764
39MP0005409_darkened_coat_color1.55907634
40MP0002254_reproductive_system_inflammat1.54432774
41MP0001545_abnormal_hematopoietic_system1.54176682
42MP0005397_hematopoietic_system_phenotyp1.54176682
43MP0001849_ear_inflammation1.48425729
44MP0001533_abnormal_skeleton_physiology1.46918408
45MP0003705_abnormal_hypodermis_morpholog1.43587608
46MP0002166_altered_tumor_susceptibility1.42903840
47MP0010094_abnormal_chromosome_stability1.42602683
48MP0000858_altered_metastatic_potential1.40552938
49MP0005025_abnormal_response_to1.39765903
50MP0001293_anophthalmia1.38243504
51MP0010155_abnormal_intestine_physiology1.34118222
52MP0000685_abnormal_immune_system1.33552144
53MP0000678_abnormal_parathyroid_gland1.31786949
54MP0004147_increased_porphyrin_level1.31741609
55MP0001873_stomach_inflammation1.31409416
56MP0006054_spinal_hemorrhage1.29508220
57MP0003111_abnormal_nucleus_morphology1.28454859
58MP0005381_digestive/alimentary_phenotyp1.24669419
59MP0008057_abnormal_DNA_replication1.23723738
60MP0008260_abnormal_autophagy1.21840745
61MP0000372_irregular_coat_pigmentation1.21313786
62MP0000343_altered_response_to1.20988113
63MP0005023_abnormal_wound_healing1.19619723
64MP0005310_abnormal_salivary_gland1.18686232
65MP0005451_abnormal_body_composition1.17984319
66MP0005257_abnormal_intraocular_pressure1.17911049
67MP0000371_diluted_coat_color1.17642106
68MP0000465_gastrointestinal_hemorrhage1.17381975
69MP0009278_abnormal_bone_marrow1.17338802
70MP0002138_abnormal_hepatobiliary_system1.17297904
71MP0008007_abnormal_cellular_replicative1.16986019
72MP0006082_CNS_inflammation1.15563188
73MP0005464_abnormal_platelet_physiology1.15354958
74MP0000689_abnormal_spleen_morphology1.14237617
75MP0008469_abnormal_protein_level1.13637753
76MP0002019_abnormal_tumor_incidence1.12738469
77MP0005377_hearing/vestibular/ear_phenot1.11541725
78MP0003878_abnormal_ear_physiology1.11541725
79MP0002398_abnormal_bone_marrow1.11388972
80MP0002009_preneoplasia1.11201944
81MP0001853_heart_inflammation1.11030280
82MP0002722_abnormal_immune_system1.10657499
83MP0005000_abnormal_immune_tolerance1.09948608
84MP0005174_abnormal_tail_pigmentation1.09940233
85MP0003566_abnormal_cell_adhesion1.09823814
86MP0000350_abnormal_cell_proliferation1.08037055
87MP0002452_abnormal_antigen_presenting1.07791003
88MP0002420_abnormal_adaptive_immunity1.07474597
89MP0003123_paternal_imprinting1.07403008
90MP0002419_abnormal_innate_immunity1.06836470
91MP0002429_abnormal_blood_cell1.05898057
92MP0003448_altered_tumor_morphology1.05423864
93MP0001819_abnormal_immune_cell1.04990248
94MP0003183_abnormal_peptide_metabolism1.03766048
95MP0002998_abnormal_bone_remodeling1.03559264
96MP0001672_abnormal_embryogenesis/_devel1.02915712
97MP0005380_embryogenesis_phenotype1.02915712
98MP0002088_abnormal_embryonic_growth/wei1.01790932
99MP0003984_embryonic_growth_retardation1.01736787
100MP0001800_abnormal_humoral_immune1.01031915
101MP0001958_emphysema1.00602282
102MP0000477_abnormal_intestine_morphology1.00463797
103MP0002405_respiratory_system_inflammati1.00135873
104MP0002086_abnormal_extraembryonic_tissu0.99780067
105MP0002796_impaired_skin_barrier0.99551013
106MP0002148_abnormal_hypersensitivity_rea0.99197390
107MP0004019_abnormal_vitamin_homeostasis0.97934661
108MP0000313_abnormal_cell_death0.97853030
109MP0000716_abnormal_immune_system0.97513981
110MP0002277_abnormal_respiratory_mucosa0.97190533
111MP0008875_abnormal_xenobiotic_pharmacok0.93475915
112MP0003315_abnormal_perineum_morphology0.92647926
113MP0002723_abnormal_immune_serum0.92439029
114MP0010329_abnormal_lipoprotein_level0.92004519
115MP0002877_abnormal_melanocyte_morpholog0.91739157
116MP0003172_abnormal_lysosome_physiology0.91724408
117MP0002092_abnormal_eye_morphology0.91633395
118MP0009333_abnormal_splenocyte_physiolog0.91128832
119MP0009643_abnormal_urine_homeostasis0.88127038
120MP0001845_abnormal_inflammatory_respons0.88093932
121MP0005636_abnormal_mineral_homeostasis0.88004957
122MP0003938_abnormal_ear_development0.87896852
123MP0000249_abnormal_blood_vessel0.85427942
124MP0003724_increased_susceptibility_to0.85165377
125MP0002075_abnormal_coat/hair_pigmentati0.85040876
126MP0009764_decreased_sensitivity_to0.84786978
127MP0002006_tumorigenesis0.84625864
128MP0004782_abnormal_surfactant_physiolog0.84488458
129MP0005058_abnormal_lysosome_morphology0.83791701
130MP0002136_abnormal_kidney_physiology0.83459277
131MP0002132_abnormal_respiratory_system0.83426580
132MP0003075_altered_response_to0.82633919
133MP0003828_pulmonary_edema0.82418860
134MP0004858_abnormal_nervous_system0.80020540
135MP0000609_abnormal_liver_physiology0.79443949
136MP0005666_abnormal_adipose_tissue0.78668427
137MP0001697_abnormal_embryo_size0.76893122
138MP0002932_abnormal_joint_morphology0.76879224
139MP0008058_abnormal_DNA_repair0.76826867
140MP0008932_abnormal_embryonic_tissue0.75464075
141MP0001730_embryonic_growth_arrest0.75370881
142MP0002080_prenatal_lethality0.75366149
143MP0003806_abnormal_nucleotide_metabolis0.75154361
144MP0002098_abnormal_vibrissa_morphology0.75030904
145MP0002085_abnormal_embryonic_tissue0.74136318
146MP0003868_abnormal_feces_composition0.73912145
147MP0001851_eye_inflammation0.73095937
148MP0002118_abnormal_lipid_homeostasis0.72680493
149MP0005670_abnormal_white_adipose0.72469133
150MP0003453_abnormal_keratinocyte_physiol0.71976209
151MP0005165_increased_susceptibility_to0.71070321
152MP0002933_joint_inflammation0.71021273

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.87793123
2Malnutrition (HP:0004395)4.75500311
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.58987482
4Aplastic anemia (HP:0001915)4.38558449
5Abnormality of glutamine family amino acid metabolism (HP:0010902)4.25112692
6Dynein arm defect of respiratory motile cilia (HP:0012255)4.21666692
7Absent/shortened dynein arms (HP:0200106)4.21666692
8Bilateral microphthalmos (HP:0007633)4.11722224
9Abnormal respiratory epithelium morphology (HP:0012253)4.04291061
10Abnormal respiratory motile cilium morphology (HP:0005938)4.04291061
11Abnormal respiratory motile cilium physiology (HP:0012261)3.96001678
12Abnormal ciliary motility (HP:0012262)3.88420623
13Abnormal number of erythroid precursors (HP:0012131)3.85820152
14Abnormality of cells of the erythroid lineage (HP:0012130)3.85465053
15Multiple enchondromatosis (HP:0005701)3.81872166
16Decreased circulating renin level (HP:0003351)3.70136530
17Reticulocytopenia (HP:0001896)3.63632697
18Rhinitis (HP:0012384)3.59445134
19Petechiae (HP:0000967)3.58997043
20Chronic bronchitis (HP:0004469)3.57985678
21Bronchiectasis (HP:0002110)3.53358689
22Reduced antithrombin III activity (HP:0001976)3.44136098
23Elevated erythrocyte sedimentation rate (HP:0003565)3.39106068
24Recurrent sinusitis (HP:0011108)3.36337504
25Recurrent bacterial skin infections (HP:0005406)3.27822971
26Chronic diarrhea (HP:0002028)3.27791125
27Thrombocytosis (HP:0001894)3.22798839
28IgM deficiency (HP:0002850)3.11302612
29Myositis (HP:0100614)3.03687974
30Chronic otitis media (HP:0000389)3.03130359
31Bronchitis (HP:0012387)3.02147057
32Abnormality of renin-angiotensin system (HP:0000847)2.95488113
33Hemorrhage of the eye (HP:0011885)2.92900801
34Flat acetabular roof (HP:0003180)2.89817408
35Gingivitis (HP:0000230)2.89618319
36Systemic lupus erythematosus (HP:0002725)2.85553692
37Rhabdomyosarcoma (HP:0002859)2.85456160
38Gout (HP:0001997)2.79481816
39Ependymoma (HP:0002888)2.73502373
40Type I transferrin isoform profile (HP:0003642)2.70835301
41Abnormality of proline metabolism (HP:0010907)2.69747756
42Hydroxyprolinuria (HP:0003080)2.69747756
43Colitis (HP:0002583)2.63921781
44Recurrent bronchitis (HP:0002837)2.63758005
45Micronodular cirrhosis (HP:0001413)2.63055080
46Microretrognathia (HP:0000308)2.59486357
47Ileus (HP:0002595)2.58932282
48Nasal polyposis (HP:0100582)2.58821096
49Abnormal delayed hypersensitivity skin test (HP:0002963)2.58289102
50Chronic sinusitis (HP:0011109)2.57445311
51Gastrointestinal infarctions (HP:0005244)2.56197750
52Abnormality of the nasal mucosa (HP:0000433)2.55550748
53Pustule (HP:0200039)2.54006329
54Vasculitis (HP:0002633)2.53911196
55Gastrointestinal stroma tumor (HP:0100723)2.51622331
56Thin bony cortex (HP:0002753)2.50797234
57Meningitis (HP:0001287)2.49933373
58Aplasia/Hypoplasia of the sacrum (HP:0008517)2.49658803
59Inflammation of the large intestine (HP:0002037)2.49092053
60Agammaglobulinemia (HP:0004432)2.48975855
61Cellulitis (HP:0100658)2.47847858
62Metabolic alkalosis (HP:0200114)2.46989585
63Increased IgE level (HP:0003212)2.46131882
64Recurrent fungal infections (HP:0002841)2.45741158
65Gastrointestinal inflammation (HP:0004386)2.45573462
66Recurrent otitis media (HP:0000403)2.43699809
67Interstitial pulmonary disease (HP:0006530)2.41236899
68Neoplasm of striated muscle (HP:0009728)2.41114946
69Partial duplication of thumb phalanx (HP:0009944)2.40145418
70Hyperactive renin-angiotensin system (HP:0000841)2.35279030
71Ragged-red muscle fibers (HP:0003200)2.34353777
72Trismus (HP:0000211)2.33359387
73Abnormality of monocarboxylic acid metabolism (HP:0010996)2.31943903
74Chromsome breakage (HP:0040012)2.28463452
75Obstructive lung disease (HP:0006536)2.26989166
76Chronic obstructive pulmonary disease (HP:0006510)2.26989166
77Spontaneous hematomas (HP:0007420)2.26888448
78Alkalosis (HP:0001948)2.26718960
79Recurrent gram-negative bacterial infections (HP:0005420)2.24377017
80Chromosomal breakage induced by crosslinking agents (HP:0003221)2.22865423
81Abnormality of the distal phalanges of the toes (HP:0010182)2.19545573
82Colon cancer (HP:0003003)2.17812884
83Widely patent fontanelles and sutures (HP:0004492)2.16995395
84Recurrent viral infections (HP:0004429)2.16952371
85Renal salt wasting (HP:0000127)2.14622505
86Partial duplication of the phalanx of hand (HP:0009999)2.14589981
87Orchitis (HP:0100796)2.14231037
88Hypoplasia of the fovea (HP:0007750)2.13708073
89Aplasia/Hypoplasia of the fovea (HP:0008060)2.13708073
90Abnormal protein glycosylation (HP:0012346)2.13645837
91Abnormal glycosylation (HP:0012345)2.13645837
92Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.13645837
93Abnormal protein N-linked glycosylation (HP:0012347)2.13645837
94Panhypogammaglobulinemia (HP:0003139)2.13640820
95Hepatoblastoma (HP:0002884)2.13279095
96Villous atrophy (HP:0011473)2.13208059
97Abnormality of small intestinal villus morphology (HP:0011472)2.13208059
98Abnormal cartilage morphology (HP:0002763)2.12801524
99Premature loss of primary teeth (HP:0006323)2.12016637
100Mediastinal lymphadenopathy (HP:0100721)2.10627793
101Abnormality of the vitamin B12 metabolism (HP:0004341)2.10421302
102Radial bowing (HP:0002986)2.10159528
103Myelodysplasia (HP:0002863)2.09256051
104Encephalitis (HP:0002383)2.08791388
105Recurrent skin infections (HP:0001581)2.06849860
106Fused cervical vertebrae (HP:0002949)2.06308362
107Nephroblastoma (Wilms tumor) (HP:0002667)2.05552500
108Hand muscle atrophy (HP:0009130)2.03153943
109Osteomyelitis (HP:0002754)2.02900783
110Vacuolated lymphocytes (HP:0001922)2.01861732
111Abdominal distention (HP:0003270)2.01568211
112Pallor (HP:0000980)2.00912704
113Emphysema (HP:0002097)2.00623064
114Recurrent abscess formation (HP:0002722)2.00063601
115Rib fusion (HP:0000902)1.97824425
116Abnormality of the salivary glands (HP:0010286)1.97017196
117Recurrent pneumonia (HP:0006532)1.95619503
118Optic neuritis (HP:0100653)1.94772966
119Retrobulbar optic neuritis (HP:0100654)1.94772966
120Impaired platelet aggregation (HP:0003540)1.94349837
121Abnormal platelet function (HP:0011869)1.94349837
122Prolonged bleeding time (HP:0003010)1.93640145
123Fat malabsorption (HP:0002630)1.92787036
12411 pairs of ribs (HP:0000878)1.92782937
125Hyperaldosteronism (HP:0000859)1.92290629
126Growth hormone excess (HP:0000845)1.90481237
127Segmental peripheral demyelination/remyelination (HP:0003481)1.89559254
128Selective tooth agenesis (HP:0001592)1.86806431
129Abnormality of vitamin B metabolism (HP:0004340)1.86506563
130Macrocytic anemia (HP:0001972)1.86480266
131Pancytopenia (HP:0001876)1.86374078
132Hemoptysis (HP:0002105)1.85197074
133Pulmonary infiltrates (HP:0002113)1.83770111
134Abnormality of the prostate (HP:0008775)1.83456031
135Amyloidosis (HP:0011034)1.83318536
136Vaginal fistula (HP:0004320)1.82817099
137Polygenic inheritance (HP:0010982)1.82726724
138Progressive muscle weakness (HP:0003323)1.81850357
139Embryonal renal neoplasm (HP:0011794)1.81753948
140Congenital sensorineural hearing impairment (HP:0008527)1.81507556
141Agnosia (HP:0010524)1.81475692
142Cervical subluxation (HP:0003308)1.81351935
143Metaphyseal cupping (HP:0003021)1.81257286
144Urticaria (HP:0001025)1.81172665
145Stomatitis (HP:0010280)1.81050630
146Preauricular skin tag (HP:0000384)1.80428689
147Cheilitis (HP:0100825)1.80102567
148Carpal bone hypoplasia (HP:0001498)1.78981253
149Abnormal lung lobation (HP:0002101)1.78631605
150Glossoptosis (HP:0000162)1.77672148
151Abnormal hemoglobin (HP:0011902)1.77639326
152Hypochromic microcytic anemia (HP:0004840)1.76949089
153Meckel diverticulum (HP:0002245)1.76466172
154Skin rash (HP:0000988)1.76311032
155Spinal muscular atrophy (HP:0007269)1.76288685
156Missing ribs (HP:0000921)1.75970433
157Small intestinal stenosis (HP:0012848)1.75770932
158Duodenal stenosis (HP:0100867)1.75770932
159Hyponatremia (HP:0002902)1.75762930
160Hypophosphatemia (HP:0002148)1.75247517
161Poor head control (HP:0002421)1.74933648
162Hypotension (HP:0002615)1.74762674
163Hyperkalemia (HP:0002153)1.73884794
164Lymphopenia (HP:0001888)1.73611815
165Aplasia/Hypoplasia of the macula (HP:0008059)1.73199115
166Abnormality of T cell physiology (HP:0011840)1.73008845
167Restrictive lung disease (HP:0002091)1.72767444
168Rough bone trabeculation (HP:0100670)1.71966360
169Recurrent cutaneous fungal infections (HP:0011370)1.71956053
170Sparse eyelashes (HP:0000653)1.71264597
171Abnormality of macrophages (HP:0004311)1.71161841
172Rectovaginal fistula (HP:0000143)1.69390714
173Rectal fistula (HP:0100590)1.69390714
174Hypochromic anemia (HP:0001931)1.66365610
175Chest pain (HP:0100749)1.64534783
176Purpura (HP:0000979)1.63876788
177Abnormality of chloride homeostasis (HP:0011422)1.63535365
178Adenoma sebaceum (HP:0009720)1.62925426
179Angiofibromas (HP:0010615)1.62925426
180Abnormality of the ileum (HP:0001549)1.62793106
181Aplasia/Hypoplasia affecting the retina (HP:0008061)1.62640844
182Periodontitis (HP:0000704)1.62605490
183Skin tags (HP:0010609)1.61417455
184Aplasia/hypoplasia of the humerus (HP:0006507)1.60609128
185Tongue fasciculations (HP:0001308)1.58417697
186Microvesicular hepatic steatosis (HP:0001414)1.55592902
187Epistaxis (HP:0000421)1.54012486

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.05106514
2CDK123.83075034
3RIPK43.62281343
4GRK62.78975743
5EPHA22.76707164
6TGFBR22.76026172
7MATK2.68220412
8CSF1R2.48616201
9PRPF4B2.46008121
10PAK42.43954191
11NME22.26828528
12WEE12.23673352
13ADRBK22.21279300
14MAPK152.20683633
15STK102.19356079
16PKN22.16051496
17PRKG21.96688333
18FLT31.86644096
19KIT1.84684333
20MST41.81440147
21RPS6KB21.81095915
22GRK51.80888946
23SRPK11.68765087
24LRRK21.68575266
25GRK11.67235627
26CDK71.64797146
27ACVR1B1.63687881
28EPHB11.61670604
29TTK1.58938572
30STK161.53764008
31SMG11.49288117
32EIF2AK31.45484421
33FES1.42743377
34FGFR41.42677019
35MST1R1.42512925
36TESK21.39200902
37MAP4K11.37186159
38TAOK11.34797066
39MAP3K141.31590433
40TGFBR11.27538328
41IKBKE1.25158652
42TXK1.23582652
43MAP3K21.23145468
44BUB11.21656812
45SYK1.21372041
46MAP3K11.20493110
47BCKDK1.20040329
48BTK1.19579195
49MAP2K31.16657008
50ZAP701.16541613
51EEF2K1.15254948
52BLK1.14563347
53JAK11.13514365
54TNK21.11505827
55CDC42BPA1.09262229
56MAP2K21.08746939
57TEC1.06916631
58TRIB31.06341093
59TBK11.06085496
60MAP3K131.06001314
61MARK21.02567417
62PIM20.99431922
63MAPK70.96249385
64MAP2K60.94961075
65NEK20.94789441
66MOS0.94297208
67PDPK10.92436255
68MAP3K120.91083756
69CDC70.90257268
70IRAK40.89413247
71BMPR20.88091807
72SIK30.87379873
73SIK10.85001763
74JAK20.84463987
75LCK0.84398120
76PDK10.84325778
77EPHA30.83657527
78IKBKB0.81882950
79MAP3K30.81359662
80PLK10.78837502
81FGR0.72690138
82AURKB0.71968031
83MAP3K80.71918704
84PRKD20.71087098
85PIK3CA0.69334041
86TYK20.68715357
87MAPK110.68132309
88IRAK10.67370557
89NLK0.67262193
90RIPK10.67059539
91MAPKAPK30.66367986
92LMTK20.65998247
93DYRK1B0.65413238
94IRAK30.65220569
95EIF2AK10.64673344
96KSR20.63910686
97AKT20.62580047
98CDK80.61991796
99STK240.61124163
100CAMK40.60951029
101PRKCI0.59980339
102FYN0.59641494
103KDR0.58005830
104PRKCQ0.57994761
105MYLK0.57943938
106RPS6KA40.57854242
107EIF2AK20.57044584
108PIM10.55892662
109TIE10.54597133
110CSK0.54340714
111MAP3K100.53927568
112RPS6KL10.53419560
113RPS6KC10.53419560
114MAPK120.51333474
115RPS6KA20.51115218
116YES10.50627986
117SIK20.50451988
118CDK190.50152295
119ERBB20.49695059
120SCYL20.49228114
121MAP3K60.49120144
122CHEK20.47590678
123PRKAA20.47249437
124NME10.46966655
125DYRK30.46945399
126RET0.46679788
127GRK70.46581963
128ICK0.46315261
129PTK60.46307622
130CDK60.45447974
131CAMKK10.45164233
132MAP3K70.44301491
133PTK20.43231489
134DDR20.42989853
135CCNB10.42639085
136LYN0.42505177
137RPS6KA60.41280275
138ATR0.40606367
139FGFR30.40133865
140MAP3K110.39983668
141NEK10.39773363
142BRSK20.39303622
143PASK0.38191686
144CHUK0.37360503
145PRKCD0.37235348
146TAOK20.36768868
147CDK40.36025603
148ADRBK10.35744809
149MKNK10.34546175
150HCK0.33932011
151STK40.32495694
152ITK0.31760770
153MET0.31272152
154JAK30.28577038
155HIPK20.28518913

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.58541747
2Ribosome_Homo sapiens_hsa030103.56134849
3Mismatch repair_Homo sapiens_hsa034302.61486542
4Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.47441584
5Fat digestion and absorption_Homo sapiens_hsa049752.30843917
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.29510293
7Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.28843298
8Allograft rejection_Homo sapiens_hsa053302.26117837
9Base excision repair_Homo sapiens_hsa034102.19212420
10Other glycan degradation_Homo sapiens_hsa005112.14657822
11Graft-versus-host disease_Homo sapiens_hsa053322.14508821
12Fructose and mannose metabolism_Homo sapiens_hsa000512.13303143
13Autoimmune thyroid disease_Homo sapiens_hsa053202.11345416
14Asthma_Homo sapiens_hsa053102.02710875
15Galactose metabolism_Homo sapiens_hsa000521.85652855
16Histidine metabolism_Homo sapiens_hsa003401.84774162
17Staphylococcus aureus infection_Homo sapiens_hsa051501.84551485
18Homologous recombination_Homo sapiens_hsa034401.80018688
19Pentose phosphate pathway_Homo sapiens_hsa000301.70226022
20Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.67084352
21Pentose and glucuronate interconversions_Homo sapiens_hsa000401.64168674
22Carbohydrate digestion and absorption_Homo sapiens_hsa049731.63703521
23Type I diabetes mellitus_Homo sapiens_hsa049401.58703852
24Leishmaniasis_Homo sapiens_hsa051401.56571990
25Cyanoamino acid metabolism_Homo sapiens_hsa004601.54507918
26Arachidonic acid metabolism_Homo sapiens_hsa005901.53607089
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.49202772
28Mineral absorption_Homo sapiens_hsa049781.49196842
29Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.46072638
30Glutathione metabolism_Homo sapiens_hsa004801.44462862
31Glycosaminoglycan degradation_Homo sapiens_hsa005311.44374988
32Thyroid cancer_Homo sapiens_hsa052161.42212165
33RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.40627998
34Folate biosynthesis_Homo sapiens_hsa007901.37438127
35Cell cycle_Homo sapiens_hsa041101.37002390
36Sulfur metabolism_Homo sapiens_hsa009201.34053351
37Spliceosome_Homo sapiens_hsa030401.32350352
38Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.30352143
39Pyrimidine metabolism_Homo sapiens_hsa002401.29946540
40Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.28485990
41Vitamin B6 metabolism_Homo sapiens_hsa007501.28022725
42RNA transport_Homo sapiens_hsa030131.27141336
43Sulfur relay system_Homo sapiens_hsa041221.26796450
44Starch and sucrose metabolism_Homo sapiens_hsa005001.26207491
45Herpes simplex infection_Homo sapiens_hsa051681.24585076
46Legionellosis_Homo sapiens_hsa051341.20415380
47Drug metabolism - other enzymes_Homo sapiens_hsa009831.14976845
48Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.14159184
49Fanconi anemia pathway_Homo sapiens_hsa034601.13486731
50One carbon pool by folate_Homo sapiens_hsa006701.12356687
51Nucleotide excision repair_Homo sapiens_hsa034201.12227524
52Retinol metabolism_Homo sapiens_hsa008301.12081692
53Transcriptional misregulation in cancer_Homo sapiens_hsa052021.11355152
54Arginine biosynthesis_Homo sapiens_hsa002201.09188644
55PPAR signaling pathway_Homo sapiens_hsa033201.08991831
56Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.06990679
57Glycerolipid metabolism_Homo sapiens_hsa005611.06341438
58Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.04054499
59Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.03797004
60Viral myocarditis_Homo sapiens_hsa054161.03689259
61p53 signaling pathway_Homo sapiens_hsa041151.02582247
62RNA polymerase_Homo sapiens_hsa030201.02473584
63Proteasome_Homo sapiens_hsa030501.00689227
64Phenylalanine metabolism_Homo sapiens_hsa003600.98835084
65Glycerophospholipid metabolism_Homo sapiens_hsa005640.95501748
66N-Glycan biosynthesis_Homo sapiens_hsa005100.94347949
67Leukocyte transendothelial migration_Homo sapiens_hsa046700.92468720
68NF-kappa B signaling pathway_Homo sapiens_hsa040640.92197471
69Caffeine metabolism_Homo sapiens_hsa002320.92011387
70Hematopoietic cell lineage_Homo sapiens_hsa046400.91642954
71Acute myeloid leukemia_Homo sapiens_hsa052210.89765512
72Bile secretion_Homo sapiens_hsa049760.88410542
73Small cell lung cancer_Homo sapiens_hsa052220.87019696
742-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.85960011
75T cell receptor signaling pathway_Homo sapiens_hsa046600.84582728
76Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.84264775
77Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.83576440
78Apoptosis_Homo sapiens_hsa042100.83429794
79Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.83324765
80Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.81673204
81Chemical carcinogenesis_Homo sapiens_hsa052040.80322533
82Measles_Homo sapiens_hsa051620.80160185
83RNA degradation_Homo sapiens_hsa030180.78669658
84Shigellosis_Homo sapiens_hsa051310.78537986
85Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.78279965
86Carbon metabolism_Homo sapiens_hsa012000.78040364
87Pancreatic secretion_Homo sapiens_hsa049720.77228193
88Influenza A_Homo sapiens_hsa051640.76976008
89Chemokine signaling pathway_Homo sapiens_hsa040620.76797179
90Lysosome_Homo sapiens_hsa041420.76481203
91Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.76333234
92Antigen processing and presentation_Homo sapiens_hsa046120.75831418
93Toll-like receptor signaling pathway_Homo sapiens_hsa046200.75300970
94TNF signaling pathway_Homo sapiens_hsa046680.74179048
95Pertussis_Homo sapiens_hsa051330.73159503
96Renin-angiotensin system_Homo sapiens_hsa046140.72299086
97Vitamin digestion and absorption_Homo sapiens_hsa049770.72065447
98Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.71954985
99Non-homologous end-joining_Homo sapiens_hsa034500.71479198
100Biosynthesis of amino acids_Homo sapiens_hsa012300.70174294
101B cell receptor signaling pathway_Homo sapiens_hsa046620.69796800
102Protein digestion and absorption_Homo sapiens_hsa049740.66908175
103Notch signaling pathway_Homo sapiens_hsa043300.66901925
104Toxoplasmosis_Homo sapiens_hsa051450.65392191
105Steroid hormone biosynthesis_Homo sapiens_hsa001400.63264514
106Malaria_Homo sapiens_hsa051440.63203459
107Fatty acid degradation_Homo sapiens_hsa000710.62702870
108Adipocytokine signaling pathway_Homo sapiens_hsa049200.60408491
109Insulin resistance_Homo sapiens_hsa049310.60383088
110African trypanosomiasis_Homo sapiens_hsa051430.58797153
111Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.58365045
112Selenocompound metabolism_Homo sapiens_hsa004500.56913928
113Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.56227673
114Jak-STAT signaling pathway_Homo sapiens_hsa046300.55138032
115Ether lipid metabolism_Homo sapiens_hsa005650.54018759
116ECM-receptor interaction_Homo sapiens_hsa045120.53832874
117NOD-like receptor signaling pathway_Homo sapiens_hsa046210.53656016
118Choline metabolism in cancer_Homo sapiens_hsa052310.53108462
119Phosphatidylinositol signaling system_Homo sapiens_hsa040700.52046376
120Amoebiasis_Homo sapiens_hsa051460.51823141
121GnRH signaling pathway_Homo sapiens_hsa049120.50789126
122Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.50549466
123Sphingolipid metabolism_Homo sapiens_hsa006000.50031382
124Bladder cancer_Homo sapiens_hsa052190.49286747
125Central carbon metabolism in cancer_Homo sapiens_hsa052300.49018144
126Platelet activation_Homo sapiens_hsa046110.48926724
127Pathways in cancer_Homo sapiens_hsa052000.48603289
128Osteoclast differentiation_Homo sapiens_hsa043800.48518140
129Primary immunodeficiency_Homo sapiens_hsa053400.48479349
130Tyrosine metabolism_Homo sapiens_hsa003500.47862875
131alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.47731216
132Cysteine and methionine metabolism_Homo sapiens_hsa002700.47637633
133AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.46638982
134Purine metabolism_Homo sapiens_hsa002300.46291747
135Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.45568703
136Viral carcinogenesis_Homo sapiens_hsa052030.45390139
137Tuberculosis_Homo sapiens_hsa051520.44965220
138Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44883375
139Rheumatoid arthritis_Homo sapiens_hsa053230.44210303
140Hepatitis B_Homo sapiens_hsa051610.43984355
141Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.43651064
142Salmonella infection_Homo sapiens_hsa051320.43144268
143Hepatitis C_Homo sapiens_hsa051600.42996596
144Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.42828656
145HTLV-I infection_Homo sapiens_hsa051660.42765664
146Linoleic acid metabolism_Homo sapiens_hsa005910.41675269
147Intestinal immune network for IgA production_Homo sapiens_hsa046720.40748299
148Chronic myeloid leukemia_Homo sapiens_hsa052200.40549276
149Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.39837710
150Renin secretion_Homo sapiens_hsa049240.39169881
151Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.38266959
152Phagosome_Homo sapiens_hsa041450.37668860

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