

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | chondrocyte proliferation (GO:0035988) | 5.09618979 |
| 2 | collagen fibril organization (GO:0030199) | 4.75021733 |
| 3 | cell adhesion mediated by integrin (GO:0033627) | 4.64039022 |
| 4 | protein heterotrimerization (GO:0070208) | 4.51432954 |
| 5 | endodermal cell differentiation (GO:0035987) | 4.49469302 |
| 6 | protein localization to endosome (GO:0036010) | 4.12037174 |
| 7 | basement membrane organization (GO:0071711) | 4.10572407 |
| 8 | positive regulation of endothelial cell apoptotic process (GO:2000353) | 4.08729396 |
| 9 | wound healing, spreading of epidermal cells (GO:0035313) | 3.96613648 |
| 10 | negative regulation of fatty acid transport (GO:2000192) | 3.94571496 |
| 11 | adhesion of symbiont to host cell (GO:0044650) | 3.83025053 |
| 12 | virion attachment to host cell (GO:0019062) | 3.83025053 |
| 13 | neuron projection extension involved in neuron projection guidance (GO:1902284) | 3.78547494 |
| 14 | axon extension involved in axon guidance (GO:0048846) | 3.78547494 |
| 15 | apoptotic cell clearance (GO:0043277) | 3.77797101 |
| 16 | glial cell migration (GO:0008347) | 3.70971933 |
| 17 | regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547) | 3.65086936 |
| 18 | collagen metabolic process (GO:0032963) | 3.54094307 |
| 19 | skin morphogenesis (GO:0043589) | 3.52959768 |
| 20 | mesenchymal-epithelial cell signaling (GO:0060638) | 3.51786628 |
| 21 | planar cell polarity pathway involved in neural tube closure (GO:0090179) | 3.47994296 |
| 22 | negative regulation of smooth muscle cell migration (GO:0014912) | 3.45946217 |
| 23 | collagen catabolic process (GO:0030574) | 3.39886317 |
| 24 | wound healing, spreading of cells (GO:0044319) | 3.39484113 |
| 25 | regulation of establishment of planar polarity involved in neural tube closure (GO:0090178) | 3.29941998 |
| 26 | endothelial cell morphogenesis (GO:0001886) | 3.28962240 |
| 27 | multicellular organismal macromolecule metabolic process (GO:0044259) | 3.27294640 |
| 28 | plasma membrane repair (GO:0001778) | 3.27250478 |
| 29 | adhesion of symbiont to host (GO:0044406) | 3.27058665 |
| 30 | positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr | 3.24606000 |
| 31 | endothelial cell chemotaxis (GO:0035767) | 3.23739742 |
| 32 | positive regulation of epithelial to mesenchymal transition (GO:0010718) | 3.22726047 |
| 33 | sequestering of extracellular ligand from receptor (GO:0035581) | 3.19785399 |
| 34 | cell migration involved in sprouting angiogenesis (GO:0002042) | 3.19613920 |
| 35 | dermatan sulfate biosynthetic process (GO:0030208) | 3.19415967 |
| 36 | cellular response to interferon-alpha (GO:0035457) | 3.19269721 |
| 37 | protein retention in ER lumen (GO:0006621) | 3.18761238 |
| 38 | regulation of vascular endothelial growth factor signaling pathway (GO:1900746) | 3.17632853 |
| 39 | positive regulation of syncytium formation by plasma membrane fusion (GO:0060143) | 3.17027216 |
| 40 | maintenance of protein localization in endoplasmic reticulum (GO:0035437) | 3.15547850 |
| 41 | vascular endothelial growth factor receptor signaling pathway (GO:0048010) | 3.13988685 |
| 42 | venous blood vessel morphogenesis (GO:0048845) | 3.12896292 |
| 43 | extracellular matrix disassembly (GO:0022617) | 3.08760827 |
| 44 | regulation of protein heterodimerization activity (GO:0043497) | 3.08199649 |
| 45 | multicellular organismal catabolic process (GO:0044243) | 3.05893161 |
| 46 | multicellular organismal metabolic process (GO:0044236) | 3.04947030 |
| 47 | metanephric mesenchyme development (GO:0072075) | 3.04761274 |
| 48 | outer ear morphogenesis (GO:0042473) | 3.04108267 |
| 49 | extracellular fibril organization (GO:0043206) | 3.02079529 |
| 50 | hippo signaling (GO:0035329) | 3.01585435 |
| 51 | protein localization to cell surface (GO:0034394) | 3.01348269 |
| 52 | stress fiber assembly (GO:0043149) | 2.99097414 |
| 53 | regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition | 2.95667908 |
| 54 | glomerular basement membrane development (GO:0032836) | 2.95366628 |
| 55 | cortical actin cytoskeleton organization (GO:0030866) | 2.94613479 |
| 56 | substrate adhesion-dependent cell spreading (GO:0034446) | 2.94428336 |
| 57 | extracellular matrix assembly (GO:0085029) | 2.93220846 |
| 58 | kidney mesenchyme development (GO:0072074) | 2.92854546 |
| 59 | heparan sulfate proteoglycan biosynthetic process (GO:0015012) | 2.92077170 |
| 60 | response to laminar fluid shear stress (GO:0034616) | 2.89924003 |
| 61 | dermatan sulfate metabolic process (GO:0030205) | 2.89027718 |
| 62 | cell proliferation involved in metanephros development (GO:0072203) | 2.88455361 |
| 63 | response to fluid shear stress (GO:0034405) | 2.87193533 |
| 64 | vascular endothelial growth factor signaling pathway (GO:0038084) | 2.86967998 |
| 65 | barbed-end actin filament capping (GO:0051016) | 2.84430552 |
| 66 | positive regulation of astrocyte differentiation (GO:0048711) | 2.84078512 |
| 67 | substrate-dependent cell migration (GO:0006929) | 2.83063739 |
| 68 | retina vasculature morphogenesis in camera-type eye (GO:0061299) | 2.81517105 |
| 69 | negative regulation of nitric oxide biosynthetic process (GO:0045019) | 2.81374341 |
| 70 | regulation of early endosome to late endosome transport (GO:2000641) | 2.80259679 |
| 71 | regulation of cell migration involved in sprouting angiogenesis (GO:0090049) | 2.79777688 |
| 72 | regulation of tight junction assembly (GO:2000810) | 2.78991636 |
| 73 | COPI coating of Golgi vesicle (GO:0048205) | 2.78218431 |
| 74 | Golgi transport vesicle coating (GO:0048200) | 2.78218431 |
| 75 | axon extension (GO:0048675) | 2.76964212 |
| 76 | positive regulation of axon extension (GO:0045773) | 2.75403689 |
| 77 | positive regulation of blood vessel endothelial cell migration (GO:0043536) | 2.74351302 |
| 78 | cellular response to vitamin (GO:0071295) | 2.72202597 |
| 79 | epithelial cell-cell adhesion (GO:0090136) | 2.71644835 |
| 80 | chondroitin sulfate biosynthetic process (GO:0030206) | 2.70846128 |
| 81 | positive regulation of membrane protein ectodomain proteolysis (GO:0051044) | 2.70585858 |
| 82 | hypotonic response (GO:0006971) | 2.68668365 |
| 83 | positive regulation of extracellular matrix organization (GO:1903055) | 2.67894114 |
| 84 | negative regulation of chondrocyte differentiation (GO:0032331) | 2.67598184 |
| 85 | hyaluronan catabolic process (GO:0030214) | 2.67386585 |
| 86 | positive regulation of receptor recycling (GO:0001921) | 2.66631029 |
| 87 | blood vessel maturation (GO:0001955) | 2.66199132 |
| 88 | positive regulation of natural killer cell differentiation (GO:0032825) | 2.65789373 |
| 89 | membrane raft organization (GO:0031579) | 2.65457632 |
| 90 | cellular response to vitamin D (GO:0071305) | 2.63999818 |
| 91 | regulation of anoikis (GO:2000209) | 2.63761526 |
| 92 | bone trabecula formation (GO:0060346) | 2.62309100 |
| 93 | semaphorin-plexin signaling pathway (GO:0071526) | 2.61928525 |
| 94 | middle ear morphogenesis (GO:0042474) | 2.59611443 |
| 95 | regulation of integrin-mediated signaling pathway (GO:2001044) | 2.59273616 |
| 96 | peptidyl-proline hydroxylation (GO:0019511) | 2.58441609 |
| 97 | platelet aggregation (GO:0070527) | 2.57373377 |
| 98 | blood vessel endothelial cell migration (GO:0043534) | 2.53846525 |
| 99 | ganglion development (GO:0061548) | 2.53506886 |
| 100 | negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518) | 2.53206843 |
| 101 | endocytic recycling (GO:0032456) | 2.53169952 |
| 102 | positive regulation of osteoblast proliferation (GO:0033690) | 2.52656281 |
| 103 | adherens junction assembly (GO:0034333) | 2.51282059 |
| 104 | cortical cytoskeleton organization (GO:0030865) | 2.51247612 |
| 105 | cell-substrate junction assembly (GO:0007044) | 2.50418022 |
| 106 | negative regulation of nitric-oxide synthase activity (GO:0051001) | 2.50146967 |
| 107 | pattern specification involved in kidney development (GO:0061004) | 2.48675769 |
| 108 | regulation of SMAD protein import into nucleus (GO:0060390) | 2.48654113 |
| 109 | cellular response to vascular endothelial growth factor stimulus (GO:0035924) | 2.48186182 |
| 110 | regulation of integrin activation (GO:0033623) | 2.47586745 |
| 111 | cell migration involved in heart development (GO:0060973) | 2.47113502 |
| 112 | type B pancreatic cell proliferation (GO:0044342) | 2.46122450 |
| 113 | myeloid cell homeostasis (GO:0002262) | 2.46105543 |
| 114 | regulation of macrophage cytokine production (GO:0010935) | 2.45102166 |
| 115 | T cell apoptotic process (GO:0070231) | 2.44626936 |
| 116 | Notch signaling involved in heart development (GO:0061314) | 2.44322415 |
| 117 | cochlea morphogenesis (GO:0090103) | 2.44314126 |
| 118 | low-density lipoprotein particle clearance (GO:0034383) | 2.43486704 |
| 119 | renal filtration (GO:0097205) | 2.42655104 |
| 120 | fibril organization (GO:0097435) | 2.42598519 |
| 121 | integrin-mediated signaling pathway (GO:0007229) | 2.41547511 |
| 122 | regulation of cell aging (GO:0090342) | 2.41403729 |
| 123 | sprouting angiogenesis (GO:0002040) | 2.41397706 |
| 124 | craniofacial suture morphogenesis (GO:0097094) | 2.40755693 |
| 125 | branching involved in salivary gland morphogenesis (GO:0060445) | 2.40569631 |
| 126 | regulation of mononuclear cell migration (GO:0071675) | 2.40370107 |
| 127 | regulation of vitamin D biosynthetic process (GO:0060556) | 2.39139413 |
| 128 | Wnt signaling pathway, planar cell polarity pathway (GO:0060071) | 2.39024932 |
| 129 | negative regulation of anoikis (GO:2000811) | 2.38871300 |
| 130 | regulation of extracellular matrix disassembly (GO:0010715) | 2.38783204 |
| 131 | heterochromatin organization (GO:0070828) | 2.37969294 |
| 132 | coronary vasculature morphogenesis (GO:0060977) | 2.37550439 |
| 133 | embryonic cranial skeleton morphogenesis (GO:0048701) | 2.36121793 |
| 134 | extracellular matrix organization (GO:0030198) | 2.35917374 |
| 135 | heterotypic cell-cell adhesion (GO:0034113) | 2.35197510 |
| 136 | extracellular structure organization (GO:0043062) | 2.34823890 |
| 137 | negative regulation of leukocyte chemotaxis (GO:0002689) | 2.34795189 |
| 138 | glomerular filtration (GO:0003094) | 2.34733660 |
| 139 | regulation of branching involved in salivary gland morphogenesis (GO:0060693) | 2.34554532 |
| 140 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 2.34073713 |
| 141 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 2.34011499 |
| 142 | protein hydroxylation (GO:0018126) | 2.33496095 |
| 143 | dichotomous subdivision of an epithelial terminal unit (GO:0060600) | 2.32932946 |
| 144 | negative regulation of cartilage development (GO:0061037) | 2.32618062 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 5.62763575 |
| 2 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 5.31156242 |
| 3 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 4.59671373 |
| 4 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 4.09990288 |
| 5 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 4.09594206 |
| 6 | * RUNX2_24764292_ChIP-Seq_MC3T3_Mouse | 3.09835331 |
| 7 | CLOCK_20551151_ChIP-Seq_293T_Human | 3.08203662 |
| 8 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 2.78029828 |
| 9 | TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 2.69631377 |
| 10 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 2.53492691 |
| 11 | * ELK3_25401928_ChIP-Seq_HUVEC_Human | 2.51253699 |
| 12 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 2.49138569 |
| 13 | * CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse | 2.39627570 |
| 14 | * TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 2.36544878 |
| 15 | * RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 2.18532305 |
| 16 | BRD4_25478319_ChIP-Seq_HGPS_Human | 2.12363721 |
| 17 | HIF1A_21447827_ChIP-Seq_MCF-7_Human | 2.11538510 |
| 18 | * CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse | 2.04817187 |
| 19 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 2.02457133 |
| 20 | WT1_19549856_ChIP-ChIP_CCG9911_Human | 2.02008081 |
| 21 | SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 2.01382372 |
| 22 | * CJUN_26792858_Chip-Seq_BT549_Human | 1.99702780 |
| 23 | * ATF3_23680149_ChIP-Seq_GBM1-GSC_Human | 1.90773787 |
| 24 | * EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse | 1.87932508 |
| 25 | * SMAD2_18955504_ChIP-ChIP_HaCaT_Human | 1.84853144 |
| 26 | * SMAD3_18955504_ChIP-ChIP_HaCaT_Human | 1.84853144 |
| 27 | P300_27058665_Chip-Seq_ZR-75-30cells_Human | 1.76409799 |
| 28 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 1.73295453 |
| 29 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 1.72292287 |
| 30 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 1.70838444 |
| 31 | * KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.66744913 |
| 32 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.64506301 |
| 33 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 1.62250515 |
| 34 | * KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.61959326 |
| 35 | * UBF1/2_26484160_Chip-Seq_HMECs_Human | 1.60891961 |
| 36 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 1.60673866 |
| 37 | * NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.59024759 |
| 38 | SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse | 1.58846211 |
| 39 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 1.58667351 |
| 40 | * ATF3_27146783_Chip-Seq_COLON_Human | 1.58586406 |
| 41 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.55171585 |
| 42 | * KDM2B_26808549_Chip-Seq_K562_Human | 1.55111485 |
| 43 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 1.54227876 |
| 44 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 1.52577986 |
| 45 | * KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.51452196 |
| 46 | PPAR_26484153_Chip-Seq_NCI-H1993_Human | 1.50361439 |
| 47 | * JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 1.50128570 |
| 48 | * SMC1_22415368_ChIP-Seq_MEFs_Mouse | 1.48965404 |
| 49 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.45207324 |
| 50 | TP53_22127205_ChIP-Seq_IMR90_Human | 1.44004618 |
| 51 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.43219388 |
| 52 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 1.43166633 |
| 53 | * KDM2B_26808549_Chip-Seq_DND41_Human | 1.41306170 |
| 54 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.40240627 |
| 55 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 1.37287418 |
| 56 | * TP53_20018659_ChIP-ChIP_R1E_Mouse | 1.37118711 |
| 57 | MYC_22102868_ChIP-Seq_BL_Human | 1.36938157 |
| 58 | VDR_24763502_ChIP-Seq_THP-1_Human | 1.36309394 |
| 59 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 1.35970041 |
| 60 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 1.35012209 |
| 61 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 1.35012209 |
| 62 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 1.34506460 |
| 63 | * JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 1.34404134 |
| 64 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 1.34115621 |
| 65 | ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 1.34025018 |
| 66 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 1.31102341 |
| 67 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.30981528 |
| 68 | * TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.30376383 |
| 69 | NRF2_20460467_ChIP-Seq_MEFs_Mouse | 1.30270475 |
| 70 | NFE2L2_20460467_ChIP-Seq_MEFs_Mouse | 1.30270475 |
| 71 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.30107397 |
| 72 | TCF7_22412390_ChIP-Seq_EML_Mouse | 1.29285969 |
| 73 | * RACK7_27058665_Chip-Seq_MCF-7_Human | 1.28994054 |
| 74 | * SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 1.28240989 |
| 75 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 1.27334862 |
| 76 | * TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.26809016 |
| 77 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 1.26735169 |
| 78 | KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.26172784 |
| 79 | E2F7_22180533_ChIP-Seq_HELA_Human | 1.25872819 |
| 80 | SOX9_24532713_ChIP-Seq_HFSC_Mouse | 1.25285654 |
| 81 | * UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human | 1.23943619 |
| 82 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 1.23823493 |
| 83 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 1.22196001 |
| 84 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 1.22196001 |
| 85 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 1.22196001 |
| 86 | ZFP281_27345836_Chip-Seq_ESCs_Mouse | 1.19145263 |
| 87 | * SALL4_18804426_ChIP-ChIP_XEN_Mouse | 1.18957433 |
| 88 | * SMC3_22415368_ChIP-Seq_MEFs_Mouse | 1.18672001 |
| 89 | FOXO3_23340844_ChIP-Seq_DLD1_Human | 1.18554904 |
| 90 | * MAF_26560356_Chip-Seq_TH1_Human | 1.16410329 |
| 91 | * SA1_22415368_ChIP-Seq_MEFs_Mouse | 1.16066313 |
| 92 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 1.14951341 |
| 93 | TP53_18474530_ChIP-ChIP_U2OS_Human | 1.14294472 |
| 94 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 1.14078139 |
| 95 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 1.13465523 |
| 96 | GATA2_21666600_ChIP-Seq_HMVEC_Human | 1.12984158 |
| 97 | NKX2-5_21415370_ChIP-Seq_HL-1_Mouse | 1.12701309 |
| 98 | * ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.11961801 |
| 99 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.11935162 |
| 100 | * NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 1.11715567 |
| 101 | * MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 1.11672536 |
| 102 | FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human | 1.11259713 |
| 103 | * EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.09683822 |
| 104 | LXR_22292898_ChIP-Seq_THP-1_Human | 1.09495934 |
| 105 | EP300_21415370_ChIP-Seq_HL-1_Mouse | 1.09255096 |
| 106 | TP53_23651856_ChIP-Seq_MEFs_Mouse | 1.07920550 |
| 107 | * SOX2_20726797_ChIP-Seq_SW620_Human | 1.07894129 |
| 108 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.07202360 |
| 109 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.07133336 |
| 110 | * KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 1.05456552 |
| 111 | TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 1.03922045 |
| 112 | * KDM2B_26808549_Chip-Seq_JURKAT_Human | 1.03836603 |
| 113 | VDR_24787735_ChIP-Seq_THP-1_Human | 1.03163068 |
| 114 | * SALL4_18804426_ChIP-ChIP_MESCs_Mouse | 1.02850122 |
| 115 | * UTX_26944678_Chip-Seq_JUKART_Human | 1.02231010 |
| 116 | * STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 1.02157488 |
| 117 | EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 1.01943580 |
| 118 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 1.01712472 |
| 119 | NFIB_24661679_ChIP-Seq_LUNG_Mouse | 1.00918025 |
| 120 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.00682537 |
| 121 | * ZFP281_18757296_ChIP-ChIP_E14_Mouse | 1.00598697 |
| 122 | HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse | 1.00462880 |
| 123 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 0.99532244 |
| 124 | * TBX20_22080862_ChIP-Seq_HEART_Mouse | 0.99508233 |
| 125 | * TBX20_22328084_ChIP-Seq_HEART_Mouse | 0.99508233 |
| 126 | ESR1_21235772_ChIP-Seq_MCF-7_Human | 0.99300414 |
| 127 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 0.98706963 |
| 128 | NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human | 0.97590457 |
| 129 | DMRT1_23473982_ChIP-Seq_TESTES_Mouse | 0.97503717 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0008438_abnormal_cutaneous_collagen | 6.34074106 |
| 2 | MP0003705_abnormal_hypodermis_morpholog | 4.41990079 |
| 3 | MP0005275_abnormal_skin_tensile | 3.50386482 |
| 4 | MP0005503_abnormal_tendon_morphology | 3.39607222 |
| 5 | MP0003279_aneurysm | 3.27496733 |
| 6 | MP0005623_abnormal_meninges_morphology | 2.95922311 |
| 7 | MP0001958_emphysema | 2.78575008 |
| 8 | MP0004272_abnormal_basement_membrane | 2.73206144 |
| 9 | MP0010352_gastrointestinal_tract_polyps | 2.42604482 |
| 10 | MP0003566_abnormal_cell_adhesion | 2.37161527 |
| 11 | MP0005257_abnormal_intraocular_pressure | 2.24723343 |
| 12 | MP0000733_abnormal_muscle_development | 2.20450915 |
| 13 | * MP0003091_abnormal_cell_migration | 2.17253583 |
| 14 | MP0002877_abnormal_melanocyte_morpholog | 2.08693394 |
| 15 | MP0005023_abnormal_wound_healing | 2.02916075 |
| 16 | MP0005076_abnormal_cell_differentiation | 1.99687059 |
| 17 | MP0010030_abnormal_orbit_morphology | 1.95981258 |
| 18 | MP0006054_spinal_hemorrhage | 1.83445954 |
| 19 | MP0003300_gastrointestinal_ulcer | 1.76854174 |
| 20 | MP0005508_abnormal_skeleton_morphology | 1.69729501 |
| 21 | MP0009384_cardiac_valve_regurgitation | 1.67399017 |
| 22 | MP0005171_absent_coat_pigmentation | 1.65609264 |
| 23 | MP0003303_peritoneal_inflammation | 1.64355672 |
| 24 | MP0010368_abnormal_lymphatic_system | 1.57568264 |
| 25 | MP0000750_abnormal_muscle_regeneration | 1.55895300 |
| 26 | MP0000767_abnormal_smooth_muscle | 1.49363447 |
| 27 | MP0002060_abnormal_skin_morphology | 1.48570754 |
| 28 | MP0001243_abnormal_dermal_layer | 1.44354571 |
| 29 | MP0000569_abnormal_digit_pigmentation | 1.42626726 |
| 30 | MP0009840_abnormal_foam_cell | 1.41539048 |
| 31 | MP0003448_altered_tumor_morphology | 1.37322590 |
| 32 | * MP0005595_abnormal_vascular_smooth | 1.34313051 |
| 33 | MP0006082_CNS_inflammation | 1.32779417 |
| 34 | MP0009053_abnormal_anal_canal | 1.30886355 |
| 35 | MP0005390_skeleton_phenotype | 1.30190676 |
| 36 | MP0001299_abnormal_eye_distance/ | 1.29903552 |
| 37 | MP0002933_joint_inflammation | 1.29288131 |
| 38 | MP0004808_abnormal_hematopoietic_stem | 1.27452914 |
| 39 | MP0002896_abnormal_bone_mineralization | 1.27444373 |
| 40 | MP0002295_abnormal_pulmonary_circulatio | 1.26656149 |
| 41 | MP0001533_abnormal_skeleton_physiology | 1.26634897 |
| 42 | MP0000858_altered_metastatic_potential | 1.26133012 |
| 43 | MP0009278_abnormal_bone_marrow | 1.24797263 |
| 44 | MP0003436_decreased_susceptibility_to | 1.24676432 |
| 45 | MP0003191_abnormal_cellular_cholesterol | 1.23002471 |
| 46 | MP0003329_amyloid_beta_deposits | 1.22631457 |
| 47 | MP0003385_abnormal_body_wall | 1.22151578 |
| 48 | MP0009250_abnormal_appendicular_skeleto | 1.20264964 |
| 49 | MP0001879_abnormal_lymphatic_vessel | 1.18187280 |
| 50 | MP0000604_amyloidosis | 1.17358305 |
| 51 | MP0002998_abnormal_bone_remodeling | 1.16653011 |
| 52 | MP0010307_abnormal_tumor_latency | 1.16432887 |
| 53 | MP0002282_abnormal_trachea_morphology | 1.16222794 |
| 54 | MP0003172_abnormal_lysosome_physiology | 1.15589171 |
| 55 | MP0001542_abnormal_bone_strength | 1.15423050 |
| 56 | MP0003045_fibrosis | 1.14531484 |
| 57 | MP0000428_abnormal_craniofacial_morphol | 1.12395213 |
| 58 | MP0001348_abnormal_lacrimal_gland | 1.11778659 |
| 59 | MP0001915_intracranial_hemorrhage | 1.11505195 |
| 60 | MP0003950_abnormal_plasma_membrane | 1.06686606 |
| 61 | MP0002168_other_aberrant_phenotype | 1.06660695 |
| 62 | MP0005248_abnormal_Harderian_gland | 1.02550235 |
| 63 | MP0003942_abnormal_urinary_system | 1.01406743 |
| 64 | MP0002113_abnormal_skeleton_development | 1.01223083 |
| 65 | MP0000163_abnormal_cartilage_morphology | 0.98906881 |
| 66 | MP0000343_altered_response_to | 0.98456135 |
| 67 | * MP0003634_abnormal_glial_cell | 0.98053526 |
| 68 | MP0003283_abnormal_digestive_organ | 0.97380124 |
| 69 | MP0005197_abnormal_uvea_morphology | 0.96861347 |
| 70 | MP0002108_abnormal_muscle_morphology | 0.96807220 |
| 71 | MP0000537_abnormal_urethra_morphology | 0.94282158 |
| 72 | * MP0001614_abnormal_blood_vessel | 0.94008766 |
| 73 | MP0002128_abnormal_blood_circulation | 0.93446383 |
| 74 | MP0002115_abnormal_skeleton_extremities | 0.93101890 |
| 75 | MP0003795_abnormal_bone_structure | 0.90834025 |
| 76 | MP0002089_abnormal_postnatal_growth/wei | 0.89718145 |
| 77 | MP0002932_abnormal_joint_morphology | 0.87552753 |
| 78 | MP0003755_abnormal_palate_morphology | 0.84612586 |
| 79 | MP0004134_abnormal_chest_morphology | 0.83516225 |
| 80 | MP0005164_abnormal_response_to | 0.82852975 |
| 81 | MP0003115_abnormal_respiratory_system | 0.82571523 |
| 82 | MP0003453_abnormal_keratinocyte_physiol | 0.82279091 |
| 83 | * MP0002925_abnormal_cardiovascular_devel | 0.81318679 |
| 84 | MP0003075_altered_response_to | 0.81019583 |
| 85 | MP0004233_abnormal_muscle_weight | 0.80616097 |
| 86 | MP0001175_abnormal_lung_morphology | 0.78435032 |
| 87 | MP0008007_abnormal_cellular_replicative | 0.77955858 |
| 88 | MP0005165_increased_susceptibility_to | 0.77415587 |
| 89 | MP0002133_abnormal_respiratory_system | 0.76967467 |
| 90 | MP0005388_respiratory_system_phenotype | 0.76967467 |
| 91 | MP0000685_abnormal_immune_system | 0.76232830 |
| 92 | MP0004197_abnormal_fetal_growth/weight/ | 0.75629635 |
| 93 | MP0008260_abnormal_autophagy | 0.74034122 |
| 94 | MP0004858_abnormal_nervous_system | 0.73350425 |
| 95 | MP0004947_skin_inflammation | 0.73227142 |
| 96 | MP0005193_abnormal_anterior_eye | 0.73197829 |
| 97 | MP0000249_abnormal_blood_vessel | 0.73139415 |
| 98 | MP0002092_abnormal_eye_morphology | 0.72693450 |
| 99 | MP0003828_pulmonary_edema | 0.72569197 |
| 100 | MP0000759_abnormal_skeletal_muscle | 0.71660478 |
| 101 | MP0000432_abnormal_head_morphology | 0.70846138 |
| 102 | MP0004510_myositis | 0.70623634 |
| 103 | MP0005058_abnormal_lysosome_morphology | 0.70264437 |
| 104 | MP0001849_ear_inflammation | 0.69382868 |
| 105 | MP0004087_abnormal_muscle_fiber | 0.69147082 |
| 106 | MP0000747_muscle_weakness | 0.68119482 |
| 107 | MP0000534_abnormal_ureter_morphology | 0.67636725 |
| 108 | MP0000762_abnormal_tongue_morphology | 0.67565108 |
| 109 | MP0000778_abnormal_nervous_system | 0.67123523 |
| 110 | MP0005409_darkened_coat_color | 0.66981492 |
| 111 | MP0000049_abnormal_middle_ear | 0.65972431 |
| 112 | MP0002419_abnormal_innate_immunity | 0.65718968 |
| 113 | MP0004883_abnormal_blood_vessel | 0.64354590 |
| 114 | MP0002697_abnormal_eye_size | 0.64319844 |
| 115 | MP0000751_myopathy | 0.64256009 |
| 116 | MP0002166_altered_tumor_susceptibility | 0.63258313 |
| 117 | MP0002405_respiratory_system_inflammati | 0.62717743 |
| 118 | MP0002116_abnormal_craniofacial_bone | 0.62579144 |
| 119 | MP0005397_hematopoietic_system_phenotyp | 0.62283715 |
| 120 | MP0001545_abnormal_hematopoietic_system | 0.62283715 |
| 121 | MP0000013_abnormal_adipose_tissue | 0.62164126 |
| 122 | MP0000749_muscle_degeneration | 0.61939821 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Protrusio acetabuli (HP:0003179) | 6.90732820 |
| 2 | Premature rupture of membranes (HP:0001788) | 6.67669908 |
| 3 | Shallow orbits (HP:0000586) | 4.57884849 |
| 4 | Ankle contracture (HP:0006466) | 4.56941033 |
| 5 | Peritonitis (HP:0002586) | 4.24244328 |
| 6 | Cerebral aneurysm (HP:0004944) | 4.06406779 |
| 7 | Aortic dissection (HP:0002647) | 3.86544514 |
| 8 | Cervical subluxation (HP:0003308) | 3.74108236 |
| 9 | Vertebral compression fractures (HP:0002953) | 3.69970745 |
| 10 | Dilatation of the ascending aorta (HP:0005111) | 3.60932661 |
| 11 | Soft skin (HP:0000977) | 3.46409665 |
| 12 | Aortic aneurysm (HP:0004942) | 3.36022413 |
| 13 | Spinal rigidity (HP:0003306) | 3.32606076 |
| 14 | Increased connective tissue (HP:0009025) | 3.30677499 |
| 15 | Atrophic scars (HP:0001075) | 3.29881302 |
| 16 | Wormian bones (HP:0002645) | 3.27110523 |
| 17 | Bladder diverticulum (HP:0000015) | 3.22990693 |
| 18 | Osteolytic defects of the hand bones (HP:0009699) | 3.22270830 |
| 19 | Osteolytic defects of the phalanges of the hand (HP:0009771) | 3.22270830 |
| 20 | Abnormality of dentin (HP:0010299) | 3.21937572 |
| 21 | Genu recurvatum (HP:0002816) | 3.12041231 |
| 22 | Increased density of long bones (HP:0006392) | 3.10910248 |
| 23 | Fragile skin (HP:0001030) | 3.05678107 |
| 24 | Broad metatarsal (HP:0001783) | 3.03792366 |
| 25 | Abnormality of glycolipid metabolism (HP:0010969) | 3.02395750 |
| 26 | Abnormality of liposaccharide metabolism (HP:0010968) | 3.02395750 |
| 27 | Abnormality of glycosphingolipid metabolism (HP:0004343) | 3.02395750 |
| 28 | Neonatal short-limb short stature (HP:0008921) | 2.94004928 |
| 29 | Wrist flexion contracture (HP:0001239) | 2.92512585 |
| 30 | Blue sclerae (HP:0000592) | 2.88820095 |
| 31 | Biconcave vertebral bodies (HP:0004586) | 2.88258068 |
| 32 | Mitral valve prolapse (HP:0001634) | 2.84450902 |
| 33 | Syringomyelia (HP:0003396) | 2.77941837 |
| 34 | Spinal cord lesions (HP:0100561) | 2.77941837 |
| 35 | Short nail (HP:0001799) | 2.77454814 |
| 36 | Type 1 muscle fiber predominance (HP:0003803) | 2.75027947 |
| 37 | Follicular hyperkeratosis (HP:0007502) | 2.66220033 |
| 38 | Vascular tortuosity (HP:0004948) | 2.51232903 |
| 39 | Aortic regurgitation (HP:0001659) | 2.48760709 |
| 40 | Neurofibrillary tangles (HP:0002185) | 2.42165539 |
| 41 | Slender build (HP:0001533) | 2.41330200 |
| 42 | Bowel diverticulosis (HP:0005222) | 2.36070886 |
| 43 | Elbow flexion contracture (HP:0002987) | 2.35683277 |
| 44 | Difficulty climbing stairs (HP:0003551) | 2.34656294 |
| 45 | Deviation of the hallux (HP:0010051) | 2.34494633 |
| 46 | Abnormality of the acetabulum (HP:0003170) | 2.33596073 |
| 47 | Distal upper limb amyotrophy (HP:0007149) | 2.29444041 |
| 48 | Upper limb amyotrophy (HP:0009129) | 2.29444041 |
| 49 | Short 4th metacarpal (HP:0010044) | 2.26929166 |
| 50 | Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042) | 2.26929166 |
| 51 | Distal lower limb amyotrophy (HP:0008944) | 2.26612692 |
| 52 | Camptodactyly of toe (HP:0001836) | 2.26135743 |
| 53 | Dysostosis multiplex (HP:0000943) | 2.26048965 |
| 54 | Hallux valgus (HP:0001822) | 2.24083322 |
| 55 | Ulnar bowing (HP:0003031) | 2.24008699 |
| 56 | Aneurysm (HP:0002617) | 2.22758048 |
| 57 | Thin bony cortex (HP:0002753) | 2.22684751 |
| 58 | Mildly elevated creatine phosphokinase (HP:0008180) | 2.22625360 |
| 59 | Achilles tendon contracture (HP:0001771) | 2.21945566 |
| 60 | Hyperacusis (HP:0010780) | 2.21714447 |
| 61 | Mitral regurgitation (HP:0001653) | 2.21519873 |
| 62 | Abnormality of the peritoneum (HP:0002585) | 2.21376472 |
| 63 | Scapular winging (HP:0003691) | 2.18399059 |
| 64 | Arterial tortuosity (HP:0005116) | 2.17213270 |
| 65 | Hypoplasia of the iris (HP:0007676) | 2.14605751 |
| 66 | Radial bowing (HP:0002986) | 2.13092474 |
| 67 | Mesomelia (HP:0003027) | 2.09981887 |
| 68 | Buphthalmos (HP:0000557) | 2.09386978 |
| 69 | Coxa vara (HP:0002812) | 2.08937299 |
| 70 | Absent frontal sinuses (HP:0002688) | 2.08699734 |
| 71 | Abnormality of skull ossification (HP:0002703) | 2.08102903 |
| 72 | Joint stiffness (HP:0001387) | 2.06959537 |
| 73 | Increased variability in muscle fiber diameter (HP:0003557) | 2.02189016 |
| 74 | Mitral stenosis (HP:0001718) | 2.01492818 |
| 75 | Hyperextensible skin (HP:0000974) | 2.01411606 |
| 76 | Joint laxity (HP:0001388) | 2.01216540 |
| 77 | Mild short stature (HP:0003502) | 2.01138964 |
| 78 | Myocardial infarction (HP:0001658) | 2.01012729 |
| 79 | Broad face (HP:0000283) | 2.00154631 |
| 80 | Abnormality of the calcaneus (HP:0008364) | 1.99752447 |
| 81 | Coronal craniosynostosis (HP:0004440) | 1.99303335 |
| 82 | Cerebral inclusion bodies (HP:0100314) | 1.97707729 |
| 83 | Aortic valve stenosis (HP:0001650) | 1.95035489 |
| 84 | Spondylolisthesis (HP:0003302) | 1.92345711 |
| 85 | Subacute progressive viral hepatitis (HP:0006572) | 1.91349512 |
| 86 | Tibial bowing (HP:0002982) | 1.90894418 |
| 87 | Abnormal delivery (HP:0001787) | 1.89998940 |
| 88 | Hypoventilation (HP:0002791) | 1.89401608 |
| 89 | Abnormality of skeletal muscle fiber size (HP:0012084) | 1.88235740 |
| 90 | Aplasia/Hypoplasia involving the sinuses (HP:0009120) | 1.88142822 |
| 91 | Amyloidosis (HP:0011034) | 1.88071515 |
| 92 | Joint contractures involving the joints of the feet (HP:0100492) | 1.85525744 |
| 93 | Flexion contracture of toe (HP:0005830) | 1.85525744 |
| 94 | Overgrowth (HP:0001548) | 1.84692757 |
| 95 | Bowing of the arm (HP:0006488) | 1.84387286 |
| 96 | Bowed forearm bones (HP:0003956) | 1.84387286 |
| 97 | Asymmetry of the thorax (HP:0001555) | 1.83293148 |
| 98 | Natal tooth (HP:0000695) | 1.83265979 |
| 99 | Urinary glycosaminoglycan excretion (HP:0003541) | 1.82966982 |
| 100 | Mucopolysacchariduria (HP:0008155) | 1.82966982 |
| 101 | Decreased skull ossification (HP:0004331) | 1.82326713 |
| 102 | Breech presentation (HP:0001623) | 1.82118627 |
| 103 | Abnormality of the Achilles tendon (HP:0005109) | 1.81853583 |
| 104 | Lower limb amyotrophy (HP:0007210) | 1.81251503 |
| 105 | Vertebral arch anomaly (HP:0008438) | 1.81094603 |
| 106 | Turricephaly (HP:0000262) | 1.81021894 |
| 107 | Persistence of primary teeth (HP:0006335) | 1.79323613 |
| 108 | Abnormality of polysaccharide metabolism (HP:0011012) | 1.78266558 |
| 109 | Abnormality of glycosaminoglycan metabolism (HP:0004371) | 1.78266558 |
| 110 | Abnormality of mucopolysaccharide metabolism (HP:0011020) | 1.78266558 |
| 111 | Disproportionate tall stature (HP:0001519) | 1.77645737 |
| 112 | Spinal cord compression (HP:0002176) | 1.77306370 |
| 113 | Venous abnormality (HP:0002624) | 1.76549072 |
| 114 | Enlarged penis (HP:0000040) | 1.75316135 |
| 115 | Cupped ribs (HP:0000887) | 1.75200804 |
| 116 | Infantile muscular hypotonia (HP:0008947) | 1.74904227 |
| 117 | Nonimmune hydrops fetalis (HP:0001790) | 1.74789352 |
| 118 | Abnormality of the 4th metacarpal (HP:0010012) | 1.71927445 |
| 119 | Wide anterior fontanel (HP:0000260) | 1.70761443 |
| 120 | Aplasia/Hypoplasia of the frontal sinuses (HP:0009119) | 1.70709849 |
| 121 | Hand muscle atrophy (HP:0009130) | 1.70306038 |
| 122 | Generalized amyotrophy (HP:0003700) | 1.70239184 |
| 123 | Ectopia lentis (HP:0001083) | 1.69888812 |
| 124 | Long toe (HP:0010511) | 1.69363841 |
| 125 | Platyspondyly (HP:0000926) | 1.68334522 |
| 126 | Delayed cranial suture closure (HP:0000270) | 1.68030864 |
| 127 | Knee flexion contracture (HP:0006380) | 1.67920171 |
| 128 | Beaking of vertebral bodies (HP:0004568) | 1.65408066 |
| 129 | Broad long bones (HP:0005622) | 1.64326814 |
| 130 | Abnormality of the distal phalanges of the toes (HP:0010182) | 1.64189277 |
| 131 | Increased mean platelet volume (HP:0011877) | 1.63384132 |
| 132 | Osteopenia (HP:0000938) | 1.62911417 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TRIB3 | 4.65970394 |
| 2 | TTN | 4.37970829 |
| 3 | PKN2 | 3.38832474 |
| 4 | DDR2 | 3.15702087 |
| 5 | IRAK3 | 3.01101934 |
| 6 | ERN1 | 2.65797088 |
| 7 | PDGFRA | 2.54393773 |
| 8 | LATS2 | 2.35053253 |
| 9 | BMX | 2.34244470 |
| 10 | NME2 | 2.19119609 |
| 11 | LRRK2 | 2.16327566 |
| 12 | EEF2K | 2.08223992 |
| 13 | RPS6KA4 | 2.04731177 |
| 14 | PTK6 | 1.90188570 |
| 15 | RIPK1 | 1.89713985 |
| 16 | TRPM7 | 1.86199349 |
| 17 | PRPF4B | 1.80945960 |
| 18 | EPHB2 | 1.80365492 |
| 19 | LATS1 | 1.79761944 |
| 20 | TESK1 | 1.78752467 |
| 21 | PIM2 | 1.76857612 |
| 22 | MAP3K10 | 1.76458665 |
| 23 | ERBB4 | 1.73854704 |
| 24 | PAK4 | 1.71200419 |
| 25 | SIK1 | 1.68707840 |
| 26 | TESK2 | 1.55446179 |
| 27 | ILK | 1.48311241 |
| 28 | STK10 | 1.47915475 |
| 29 | PTK2 | 1.44582822 |
| 30 | ICK | 1.44369606 |
| 31 | NEK9 | 1.41519855 |
| 32 | LIMK1 | 1.39899011 |
| 33 | MYLK | 1.33649962 |
| 34 | TIE1 | 1.33021855 |
| 35 | SCYL2 | 1.31188999 |
| 36 | STK3 | 1.23248754 |
| 37 | ARAF | 1.22979575 |
| 38 | * PAK2 | 1.21938143 |
| 39 | DYRK1B | 1.21286909 |
| 40 | TBK1 | 1.19551642 |
| 41 | CDC42BPA | 1.15199179 |
| 42 | TGFBR2 | 1.14037582 |
| 43 | GRK7 | 1.11893113 |
| 44 | PTK2B | 1.10799976 |
| 45 | DMPK | 1.10353985 |
| 46 | LMTK2 | 1.07347618 |
| 47 | PDGFRB | 1.06112733 |
| 48 | CDK6 | 1.06038080 |
| 49 | FGFR1 | 1.04723490 |
| 50 | MAP3K13 | 1.03848311 |
| 51 | KSR1 | 1.02202964 |
| 52 | EPHB1 | 0.98701958 |
| 53 | MTOR | 0.97789004 |
| 54 | JAK3 | 0.97282644 |
| 55 | MET | 0.96327240 |
| 56 | TGFBR1 | 0.93954193 |
| 57 | CHUK | 0.89582779 |
| 58 | * MOS | 0.85748773 |
| 59 | FER | 0.85355854 |
| 60 | KSR2 | 0.84125905 |
| 61 | MAP3K6 | 0.82783194 |
| 62 | KDR | 0.82769067 |
| 63 | RPS6KA2 | 0.82678101 |
| 64 | MAP3K8 | 0.81730076 |
| 65 | CDK12 | 0.80455144 |
| 66 | EPHA3 | 0.79577843 |
| 67 | PAK3 | 0.79120290 |
| 68 | MAP2K3 | 0.78124178 |
| 69 | KIT | 0.76070787 |
| 70 | ERBB3 | 0.75659030 |
| 71 | CLK1 | 0.75404417 |
| 72 | ABL2 | 0.74008959 |
| 73 | FGFR3 | 0.70243421 |
| 74 | FLT3 | 0.69369046 |
| 75 | CAMK1D | 0.69117911 |
| 76 | NEK2 | 0.68259298 |
| 77 | JAK1 | 0.67473431 |
| 78 | CSK | 0.66801228 |
| 79 | MAP3K3 | 0.66242390 |
| 80 | INSR | 0.65835779 |
| 81 | PRKD3 | 0.63195825 |
| 82 | MAPK7 | 0.62503390 |
| 83 | RET | 0.62169932 |
| 84 | FGFR4 | 0.60776287 |
| 85 | IKBKB | 0.59268013 |
| 86 | * ROCK1 | 0.58198623 |
| 87 | MAP3K14 | 0.56688259 |
| 88 | MAP2K1 | 0.55919080 |
| 89 | * PAK1 | 0.55051867 |
| 90 | IRAK2 | 0.53433514 |
| 91 | HCK | 0.53423425 |
| 92 | CSF1R | 0.52814561 |
| 93 | CAMKK1 | 0.52669235 |
| 94 | TYK2 | 0.52618322 |
| 95 | STK38 | 0.52423757 |
| 96 | RPS6KC1 | 0.51245415 |
| 97 | RPS6KL1 | 0.51245415 |
| 98 | IRAK4 | 0.50018688 |
| 99 | MAP3K11 | 0.48609624 |
| 100 | PRKG2 | 0.47836850 |
| 101 | SRC | 0.47375259 |
| 102 | SIK2 | 0.46584233 |
| 103 | MARK1 | 0.45641324 |
| 104 | CDK8 | 0.45263457 |
| 105 | BLK | 0.44623886 |
| 106 | PRKD1 | 0.43899853 |
| 107 | EGFR | 0.42998480 |
| 108 | TAOK2 | 0.42902791 |
| 109 | WNK1 | 0.41814013 |
| 110 | PIM1 | 0.41599849 |
| 111 | GSK3A | 0.41282341 |
| 112 | ABL1 | 0.40630250 |
| 113 | DAPK3 | 0.40481979 |
| 114 | NTRK2 | 0.40092162 |
| 115 | HIPK2 | 0.40080591 |
| 116 | ZAP70 | 0.39527791 |
| 117 | * ROCK2 | 0.39418852 |
| 118 | NTRK1 | 0.38614021 |
| 119 | * CDK14 | 0.38331649 |
| 120 | MARK3 | 0.37071171 |
| 121 | ALK | 0.36958364 |
| 122 | CDK9 | 0.36356138 |
| 123 | MAP3K1 | 0.36032528 |
| 124 | PRKCH | 0.35666634 |
| 125 | MST1R | 0.34910102 |
| 126 | MAPK15 | 0.33702336 |
| 127 | * CDK11A | 0.30648261 |
| 128 | PIK3CG | 0.29937067 |
| 129 | FGR | 0.28915612 |
| 130 | CDK4 | 0.28806982 |
| 131 | EPHA2 | 0.28649216 |
| 132 | PRKD2 | 0.27105748 |
| 133 | IGF1R | 0.26341050 |
| 134 | * MAPKAPK2 | 0.24680730 |
| 135 | TYRO3 | 0.24640133 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | ECM-receptor interaction_Homo sapiens_hsa04512 | 2.82026968 |
| 2 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 2.55797053 |
| 3 | Focal adhesion_Homo sapiens_hsa04510 | 2.50960122 |
| 4 | Other glycan degradation_Homo sapiens_hsa00511 | 2.38075775 |
| 5 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 2.27633021 |
| 6 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 2.27232871 |
| 7 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 2.19888368 |
| 8 | Small cell lung cancer_Homo sapiens_hsa05222 | 2.14301316 |
| 9 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 2.10865073 |
| 10 | Viral myocarditis_Homo sapiens_hsa05416 | 2.09275776 |
| 11 | Malaria_Homo sapiens_hsa05144 | 2.01703484 |
| 12 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 1.99481547 |
| 13 | Bladder cancer_Homo sapiens_hsa05219 | 1.88064438 |
| 14 | Shigellosis_Homo sapiens_hsa05131 | 1.87967948 |
| 15 | Adherens junction_Homo sapiens_hsa04520 | 1.85865772 |
| 16 | Amoebiasis_Homo sapiens_hsa05146 | 1.84320848 |
| 17 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.75782566 |
| 18 | * MicroRNAs in cancer_Homo sapiens_hsa05206 | 1.67781164 |
| 19 | Prion diseases_Homo sapiens_hsa05020 | 1.67062547 |
| 20 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 1.66306089 |
| 21 | Leishmaniasis_Homo sapiens_hsa05140 | 1.64768234 |
| 22 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 1.57208741 |
| 23 | Toxoplasmosis_Homo sapiens_hsa05145 | 1.46891348 |
| 24 | TNF signaling pathway_Homo sapiens_hsa04668 | 1.45320991 |
| 25 | Apoptosis_Homo sapiens_hsa04210 | 1.43011344 |
| 26 | Pancreatic cancer_Homo sapiens_hsa05212 | 1.42577541 |
| 27 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 1.41012361 |
| 28 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 1.37192628 |
| 29 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 1.34171204 |
| 30 | Salmonella infection_Homo sapiens_hsa05132 | 1.33841179 |
| 31 | Osteoclast differentiation_Homo sapiens_hsa04380 | 1.32729250 |
| 32 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 1.31399586 |
| 33 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 1.28319378 |
| 34 | Hippo signaling pathway_Homo sapiens_hsa04390 | 1.26968611 |
| 35 | Phagosome_Homo sapiens_hsa04145 | 1.23780350 |
| 36 | HTLV-I infection_Homo sapiens_hsa05166 | 1.22139288 |
| 37 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | 1.19212446 |
| 38 | Viral carcinogenesis_Homo sapiens_hsa05203 | 1.18755257 |
| 39 | Melanoma_Homo sapiens_hsa05218 | 1.18565605 |
| 40 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 1.17805037 |
| 41 | Hepatitis B_Homo sapiens_hsa05161 | 1.16271818 |
| 42 | Legionellosis_Homo sapiens_hsa05134 | 1.14594057 |
| 43 | Glioma_Homo sapiens_hsa05214 | 1.14199372 |
| 44 | Platelet activation_Homo sapiens_hsa04611 | 1.14068981 |
| 45 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.08641916 |
| 46 | Tuberculosis_Homo sapiens_hsa05152 | 1.06589425 |
| 47 | Colorectal cancer_Homo sapiens_hsa05210 | 1.04376041 |
| 48 | Pertussis_Homo sapiens_hsa05133 | 1.04356961 |
| 49 | Protein digestion and absorption_Homo sapiens_hsa04974 | 1.04324197 |
| 50 | Lysosome_Homo sapiens_hsa04142 | 1.03416420 |
| 51 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 1.03340115 |
| 52 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 1.01501748 |
| 53 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 1.00343606 |
| 54 | Measles_Homo sapiens_hsa05162 | 0.99624898 |
| 55 | Prostate cancer_Homo sapiens_hsa05215 | 0.98533971 |
| 56 | Pathways in cancer_Homo sapiens_hsa05200 | 0.97114795 |
| 57 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.97035949 |
| 58 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.96282482 |
| 59 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.95947863 |
| 60 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 0.95010075 |
| 61 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.91297598 |
| 62 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.90508534 |
| 63 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.89699285 |
| 64 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 0.88946419 |
| 65 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.88281396 |
| 66 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.84595735 |
| 67 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.84507974 |
| 68 | Endometrial cancer_Homo sapiens_hsa05213 | 0.84298303 |
| 69 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.80806706 |
| 70 | Gap junction_Homo sapiens_hsa04540 | 0.79976627 |
| 71 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.78892382 |
| 72 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.77470904 |
| 73 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.76638036 |
| 74 | Cell cycle_Homo sapiens_hsa04110 | 0.75772719 |
| 75 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.75539013 |
| 76 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.74785164 |
| 77 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.74218452 |
| 78 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.73910423 |
| 79 | Thyroid cancer_Homo sapiens_hsa05216 | 0.73413838 |
| 80 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 0.72958336 |
| 81 | Melanogenesis_Homo sapiens_hsa04916 | 0.72498541 |
| 82 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.72107782 |
| 83 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.71620986 |
| 84 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.71445756 |
| 85 | Galactose metabolism_Homo sapiens_hsa00052 | 0.71007839 |
| 86 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.70321071 |
| 87 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.69640994 |
| 88 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.69326886 |
| 89 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.69309196 |
| 90 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.68135159 |
| 91 | Endocytosis_Homo sapiens_hsa04144 | 0.67783748 |
| 92 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.66899945 |
| 93 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.65056751 |
| 94 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.64662293 |
| 95 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.64512614 |
| 96 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.64105902 |
| 97 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.64035551 |
| 98 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.62260930 |
| 99 | Tight junction_Homo sapiens_hsa04530 | 0.62099673 |
| 100 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.61581239 |
| 101 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.61473775 |
| 102 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.61147954 |
| 103 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.59090187 |
| 104 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 0.57386020 |
| 105 | Influenza A_Homo sapiens_hsa05164 | 0.57212936 |
| 106 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.57104401 |
| 107 | Hepatitis C_Homo sapiens_hsa05160 | 0.57067667 |
| 108 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.55773001 |
| 109 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.54876761 |
| 110 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.54650298 |
| 111 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.54615370 |
| 112 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.54122989 |
| 113 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.53890413 |
| 114 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.51014046 |
| 115 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.50356018 |
| 116 | Axon guidance_Homo sapiens_hsa04360 | 0.49961342 |
| 117 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.49944984 |
| 118 | * Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.48212578 |
| 119 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.47931535 |
| 120 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.45641501 |
| 121 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.45302669 |
| 122 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.44473641 |

