VIP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the glucagon family. It stimulates myocardial contractility, causes vasodilation, increases glycogenolysis, lowers arterial blood pressure and relaxes the smooth muscle of trachea, stomach and gall bladder. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1locomotory exploration behavior (GO:0035641)8.37423009
2negative regulation of norepinephrine secretion (GO:0010700)8.02859199
3negative regulation of catecholamine secretion (GO:0033604)7.45643088
4succinate metabolic process (GO:0006105)7.13839807
5synaptic vesicle docking involved in exocytosis (GO:0016081)6.94510274
6synaptic vesicle maturation (GO:0016188)6.82191356
7regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)6.77986677
8positive regulation of dendritic spine morphogenesis (GO:0061003)6.56230893
9behavioral response to ethanol (GO:0048149)6.50182527
10vocalization behavior (GO:0071625)6.47608173
11startle response (GO:0001964)6.21312698
12parturition (GO:0007567)6.18171633
13positive regulation of excitatory postsynaptic membrane potential (GO:2000463)6.11240669
14positive regulation of digestive system process (GO:0060456)5.97812131
15negative regulation of amine transport (GO:0051953)5.76742263
16glucocorticoid biosynthetic process (GO:0006704)5.71334850
17neuron cell-cell adhesion (GO:0007158)5.69196962
18cellular response to ammonium ion (GO:0071242)5.60873733
19glutamate secretion (GO:0014047)5.52502477
20regulation of gonadotropin secretion (GO:0032276)5.45514443
21exploration behavior (GO:0035640)5.38865617
22neurotransmitter biosynthetic process (GO:0042136)5.07130712
23synaptic transmission, dopaminergic (GO:0001963)5.02102399
24regulation of glucocorticoid secretion (GO:2000849)4.98526782
25short-term memory (GO:0007614)4.94320355
26negative regulation of synaptic transmission, GABAergic (GO:0032229)4.92227663
27regulation of glutamate receptor signaling pathway (GO:1900449)4.88440162
28cardiac ventricle formation (GO:0003211)4.82395873
29regulation of synaptic vesicle transport (GO:1902803)4.78206410
30positive regulation of steroid hormone secretion (GO:2000833)4.75225394
31regulation of short-term neuronal synaptic plasticity (GO:0048172)4.73826570
32protein-cofactor linkage (GO:0018065)4.67461782
33regulation of norepinephrine secretion (GO:0014061)4.65023979
34ionotropic glutamate receptor signaling pathway (GO:0035235)4.54289558
35positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003574.50069787
36neurotransmitter secretion (GO:0007269)4.49025142
37cardiac chamber formation (GO:0003207)4.43225751
38long-term synaptic potentiation (GO:0060291)4.43120940
39positive regulation of dendritic spine development (GO:0060999)4.42882600
40regulation of dendritic spine morphogenesis (GO:0061001)4.41179247
41dicarboxylic acid catabolic process (GO:0043649)4.39403078
42neuron-neuron synaptic transmission (GO:0007270)4.39143113
43positive regulation of circadian rhythm (GO:0042753)4.38778890
44cellular potassium ion homeostasis (GO:0030007)4.36377709
45presynaptic membrane assembly (GO:0097105)4.32792189
46positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.32664782
47regulation of long-term neuronal synaptic plasticity (GO:0048169)4.30684111
48regulation of neuronal synaptic plasticity (GO:0048168)4.30656681
49hypothalamus development (GO:0021854)4.29037026
50prostate gland growth (GO:0060736)4.28361986
51ATP hydrolysis coupled proton transport (GO:0015991)4.24002237
52energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)4.24002237
53regulation of excitatory postsynaptic membrane potential (GO:0060079)4.22793383
54aggressive behavior (GO:0002118)4.20545075
55neurotransmitter-gated ion channel clustering (GO:0072578)4.20300903
56regulation of circadian sleep/wake cycle, sleep (GO:0045187)4.20024552
57regulation of circadian sleep/wake cycle (GO:0042749)4.20024552
58gamma-aminobutyric acid transport (GO:0015812)4.14321476
59transferrin transport (GO:0033572)4.09896534
60positive regulation of synapse assembly (GO:0051965)4.06863785
61regulation of corticosteroid hormone secretion (GO:2000846)4.05506591
62positive regulation of membrane potential (GO:0045838)4.03789338
63response to histamine (GO:0034776)4.01929080
64response to cocaine (GO:0042220)4.00580438
65synaptic vesicle exocytosis (GO:0016079)3.97936947
66regulation of postsynaptic membrane potential (GO:0060078)3.95126688
67positive regulation of synapse maturation (GO:0090129)3.92585671
68regulation of neurotransmitter secretion (GO:0046928)3.91576712
69trivalent inorganic cation transport (GO:0072512)3.90197469
70ferric iron transport (GO:0015682)3.90197469
71negative regulation of dendrite morphogenesis (GO:0050774)3.89924689
72gamma-aminobutyric acid signaling pathway (GO:0007214)3.88272974
73regulation of glutamate secretion (GO:0014048)3.85854409
74sodium ion export (GO:0071436)3.84982575
75regulation of action potential (GO:0098900)3.84366800
76regulation of dendritic spine development (GO:0060998)3.82241020
77positive regulation of neurotransmitter secretion (GO:0001956)3.80627003
78mitochondrial fragmentation involved in apoptotic process (GO:0043653)3.79490885
79circadian sleep/wake cycle process (GO:0022410)3.77292202
80presynaptic membrane organization (GO:0097090)3.74925109
81female mating behavior (GO:0060180)3.73655515
82regulation of synapse structural plasticity (GO:0051823)3.71487951
83glucocorticoid metabolic process (GO:0008211)3.70610723
84negative regulation of amino acid transport (GO:0051956)3.70247853
85long-term memory (GO:0007616)3.68673552
86neurotransmitter metabolic process (GO:0042133)3.67832938
87regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.66278805
88positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.65898859
89* regulation of penile erection (GO:0060405)3.65782333
90behavioral fear response (GO:0001662)3.61079946
91behavioral defense response (GO:0002209)3.61079946
92regulation of female receptivity (GO:0045924)3.59994253
93regulation of sarcomere organization (GO:0060297)3.59929933
94vesicle docking involved in exocytosis (GO:0006904)3.58618130
95prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.56376829
96negative regulation of mast cell activation (GO:0033004)3.55305193
97dendritic spine morphogenesis (GO:0060997)3.55058669
98cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.52266364
99vesicle docking (GO:0048278)3.51363942
100regulation of synapse maturation (GO:0090128)3.49095573
101regulation of neurotransmitter transport (GO:0051588)3.48029427
102neuronal action potential propagation (GO:0019227)3.44059014
103G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.43827245
104cerebellar granule cell differentiation (GO:0021707)3.41609646
105positive regulation of calcium ion import (GO:0090280)3.41033608
106regulation of synaptic vesicle exocytosis (GO:2000300)3.38603573
107positive regulation of neurotransmitter transport (GO:0051590)3.35447195
108membrane depolarization (GO:0051899)3.35152632
109postsynaptic membrane organization (GO:0001941)3.34866682
110regulation of voltage-gated calcium channel activity (GO:1901385)3.34851698
111regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.34272756
112glutamate receptor signaling pathway (GO:0007215)3.33975680
113auditory behavior (GO:0031223)3.33880676
114regulation of catecholamine secretion (GO:0050433)3.31712808
115positive regulation of action potential (GO:0045760)3.29842964
116neurotransmitter transport (GO:0006836)3.29493624
117sympathetic nervous system development (GO:0048485)3.28066679
118regulation of pigment cell differentiation (GO:0050932)3.27621903
119positive regulation of muscle hypertrophy (GO:0014742)3.27453266
120positive regulation of cardiac muscle hypertrophy (GO:0010613)3.27453266
121cellular response to dexamethasone stimulus (GO:0071549)3.27048329
122proline transport (GO:0015824)3.27018933
123protein localization to synapse (GO:0035418)3.24409747
124glial cell proliferation (GO:0014009)3.23900792
125fear response (GO:0042596)3.23758171
126negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.23064069
127negative regulation of dendrite development (GO:2000171)3.22076523
128negative regulation of circadian rhythm (GO:0042754)3.21439358
129membrane hyperpolarization (GO:0060081)3.19831408
130detection of calcium ion (GO:0005513)3.18577802
131cartilage morphogenesis (GO:0060536)3.17582966
132lung vasculature development (GO:0060426)3.16794644
133regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.16546816
134regulation of synaptic plasticity (GO:0048167)3.16504062
135regulation of dopamine secretion (GO:0014059)3.13981996
136regulation of neurotransmitter levels (GO:0001505)3.13732862
137regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.11456012
138regulation of synaptic transmission, glutamatergic (GO:0051966)3.08730236
139response to dexamethasone (GO:0071548)3.08021160
140synaptic transmission, glutamatergic (GO:0035249)3.07078021
141lymphangiogenesis (GO:0001946)3.05795613
142membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.05196831
143lung lobe morphogenesis (GO:0060463)3.04016207
144behavioral response to nicotine (GO:0035095)3.03232509
145potassium ion homeostasis (GO:0055075)3.02370646
146mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.01891903
147glutamine family amino acid catabolic process (GO:0009065)3.01342681
148nerve growth factor signaling pathway (GO:0038180)3.01176095
149dendritic spine organization (GO:0097061)2.99049420
150L-amino acid import (GO:0043092)2.98120391
151cell communication by electrical coupling (GO:0010644)2.95867213
152regulation of synapse assembly (GO:0051963)2.91173068
153membrane depolarization during action potential (GO:0086010)2.91013527
154regulation of dendrite morphogenesis (GO:0048814)2.88258962
155serotonin metabolic process (GO:0042428)2.80965483
156activation of protein kinase A activity (GO:0034199)2.78697039
157cardiac conduction (GO:0061337)2.78103344
158positive regulation of dendrite morphogenesis (GO:0050775)2.74211501
159layer formation in cerebral cortex (GO:0021819)2.74128865
160cell differentiation in hindbrain (GO:0021533)2.72319757
161memory (GO:0007613)2.69640738
162regulation of synapse organization (GO:0050807)2.68281701
163cell migration in hindbrain (GO:0021535)2.68033683
164positive regulation of dendrite development (GO:1900006)2.67999022
165regulation of synaptic transmission (GO:0050804)2.65004194
166phenylpropanoid metabolic process (GO:0009698)10.1588124

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.49660552
2GBX2_23144817_ChIP-Seq_PC3_Human4.33515072
3TAF15_26573619_Chip-Seq_HEK293_Human3.97707066
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.30093243
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.04093890
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.97199027
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.82449411
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.78083491
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.60032503
10CTBP2_25329375_ChIP-Seq_LNCAP_Human2.54288165
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.52479171
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.48899098
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.46668244
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.45588225
15EED_16625203_ChIP-ChIP_MESCs_Mouse2.37815853
16FUS_26573619_Chip-Seq_HEK293_Human2.34766734
17* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.33589553
18* CTBP1_25329375_ChIP-Seq_LNCAP_Human2.27331305
19JARID2_20075857_ChIP-Seq_MESCs_Mouse2.25131288
20SMAD4_21799915_ChIP-Seq_A2780_Human2.23852792
21EZH2_18974828_ChIP-Seq_MESCs_Mouse2.19870396
22RNF2_18974828_ChIP-Seq_MESCs_Mouse2.19870396
23SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.18576724
24EZH2_27304074_Chip-Seq_ESCs_Mouse2.16686654
25MTF2_20144788_ChIP-Seq_MESCs_Mouse2.16679100
26* REST_21632747_ChIP-Seq_MESCs_Mouse2.12439469
27P300_19829295_ChIP-Seq_ESCs_Human2.03670951
28IGF1R_20145208_ChIP-Seq_DFB_Human1.96998342
29REST_18959480_ChIP-ChIP_MESCs_Mouse1.96071515
30EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.95610928
31THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.93634656
32PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.93398718
33SUZ12_27294783_Chip-Seq_ESCs_Mouse1.92019779
34EZH2_27294783_Chip-Seq_ESCs_Mouse1.81716615
35SMAD_19615063_ChIP-ChIP_OVARY_Human1.78836372
36RNF2_27304074_Chip-Seq_ESCs_Mouse1.75966961
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.70437783
38SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.70351827
39OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.69723184
40CBX2_27304074_Chip-Seq_ESCs_Mouse1.68453878
41SMAD3_21741376_ChIP-Seq_EPCs_Human1.68427365
42ER_23166858_ChIP-Seq_MCF-7_Human1.65543494
43CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.63019434
44GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.61244375
45* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.60758102
46SOX2_21211035_ChIP-Seq_LN229_Gbm1.60704971
47CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.60113297
48MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.58646522
49SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.58107969
50IKZF1_21737484_ChIP-ChIP_HCT116_Human1.57064876
51PIAS1_25552417_ChIP-Seq_VCAP_Human1.55670097
52CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.54984352
53POU3F2_20337985_ChIP-ChIP_501MEL_Human1.53747854
54RARB_27405468_Chip-Seq_BRAIN_Mouse1.49907961
55SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.49192160
56UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.46764554
57RNF2_27304074_Chip-Seq_NSC_Mouse1.46749324
58RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.43927327
59HTT_18923047_ChIP-ChIP_STHdh_Human1.43838949
60TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.43613236
61ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.42644593
62GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.40908405
63* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.40137921
64* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.38688326
65ERG_21242973_ChIP-ChIP_JURKAT_Human1.38252881
66PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.37419139
67* TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37203272
68FLI1_27457419_Chip-Seq_LIVER_Mouse1.36423411
69AR_25329375_ChIP-Seq_VCAP_Human1.35382876
70DROSHA_22980978_ChIP-Seq_HELA_Human1.33187771
71TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.31010848
72ARNT_22903824_ChIP-Seq_MCF-7_Human1.30807060
73NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.30694809
74RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.29906962
75JUN_21703547_ChIP-Seq_K562_Human1.29667033
76DNAJC2_21179169_ChIP-ChIP_NT2_Human1.28013588
77P53_22127205_ChIP-Seq_FIBROBLAST_Human1.27857269
78TCF4_23295773_ChIP-Seq_U87_Human1.27642113
79WT1_25993318_ChIP-Seq_PODOCYTE_Human1.25515909
80AHR_22903824_ChIP-Seq_MCF-7_Human1.25510977
81PCGF2_27294783_Chip-Seq_ESCs_Mouse1.25487143
82* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.20913732
83AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.20744217
84AR_21572438_ChIP-Seq_LNCaP_Human1.20727857
85SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19510284
86NANOG_18555785_Chip-Seq_ESCs_Mouse1.18953687
87RUNX2_22187159_ChIP-Seq_PCA_Human1.17052998
88IRF1_19129219_ChIP-ChIP_H3396_Human1.15876944
89RING1B_27294783_Chip-Seq_ESCs_Mouse1.15173436
90VDR_22108803_ChIP-Seq_LS180_Human1.13228534
91PRDM14_20953172_ChIP-Seq_ESCs_Human1.12208877
92EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.10122559
93ZNF274_21170338_ChIP-Seq_K562_Hela1.07822741
94BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.07304181
95CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.05936359
96EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.05673712
97ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.05297652
98TP53_16413492_ChIP-PET_HCT116_Human1.05225815
99AR_19668381_ChIP-Seq_PC3_Human1.04934075
100STAT3_23295773_ChIP-Seq_U87_Human1.04503029
101POU5F1_16153702_ChIP-ChIP_HESCs_Human1.04078576
102YAP1_20516196_ChIP-Seq_MESCs_Mouse1.03563988
103NR3C1_23031785_ChIP-Seq_PC12_Mouse1.03407059
104ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.02750367
105TCF4_18268006_ChIP-ChIP_LS174T_Human1.02040030
106CTNNB1_20460455_ChIP-Seq_HCT116_Human1.00734327
107CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.00400424
108MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.99602359
109IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.98381980
110CBP_20019798_ChIP-Seq_JUKART_Human0.98381980
111TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96980006
112POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.96812642
113TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96812642
114KDM2B_26808549_Chip-Seq_REH_Human0.96575798
115TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96415803
116NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96319920
117RING1B_27294783_Chip-Seq_NPCs_Mouse0.94690852
118TET1_21490601_ChIP-Seq_MESCs_Mouse0.94109905
119CDX2_19796622_ChIP-Seq_MESCs_Mouse0.94055839
120RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93856585
121TAL1_26923725_Chip-Seq_HPCs_Mouse0.93805131
122P53_22387025_ChIP-Seq_ESCs_Mouse0.93063186
123TP53_18474530_ChIP-ChIP_U2OS_Human0.92543958
124LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91737039
125TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.90485710
126CTCF_27219007_Chip-Seq_Bcells_Human0.89284937
127SMAD3_21741376_ChIP-Seq_ESCs_Human0.87848201
128RXR_22108803_ChIP-Seq_LS180_Human0.87817462
129SMAD4_21741376_ChIP-Seq_HESCs_Human0.86942907
130ZFP281_18757296_ChIP-ChIP_E14_Mouse0.86010530
131ZNF217_24962896_ChIP-Seq_MCF-7_Human0.85951242
132SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.83657525
133LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.82606550
134PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.82475157
135EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.81677043
136ESR2_21235772_ChIP-Seq_MCF-7_Human0.81028338
137KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.80985085
138RUNX1_26923725_Chip-Seq_HPCs_Mouse0.79130334
139* KLF4_19829295_ChIP-Seq_ESCs_Human0.78019684

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy5.27087897
2MP0002837_dystrophic_cardiac_calcinosis4.17478460
3MP0009780_abnormal_chondrocyte_physiolo3.97461588
4MP0004859_abnormal_synaptic_plasticity3.78625491
5MP0009745_abnormal_behavioral_response3.42393673
6MP0009046_muscle_twitch3.27181861
7MP0002064_seizures3.20749521
8MP0003635_abnormal_synaptic_transmissio3.12597337
9MP0003880_abnormal_central_pattern2.97584694
10MP0001188_hyperpigmentation2.91019580
11MP0000013_abnormal_adipose_tissue2.82187319
12MP0004782_abnormal_surfactant_physiolog2.67812662
13MP0002876_abnormal_thyroid_physiology2.62481521
14MP0002735_abnormal_chemical_nociception2.54929783
15MP0002063_abnormal_learning/memory/cond2.53369052
16MP0002272_abnormal_nervous_system2.37774696
17MP0002572_abnormal_emotion/affect_behav2.29594177
18MP0008260_abnormal_autophagy2.26895585
19MP0001501_abnormal_sleep_pattern2.26167376
20MP0005646_abnormal_pituitary_gland2.19787831
21MP0003787_abnormal_imprinting2.14637120
22MP0002734_abnormal_mechanical_nocicepti2.14327791
23MP0010368_abnormal_lymphatic_system2.06372175
24MP0003718_maternal_effect2.01469913
25MP0003122_maternal_imprinting1.92385950
26MP0001486_abnormal_startle_reflex1.87385435
27MP0004147_increased_porphyrin_level1.85690538
28MP0001270_distended_abdomen1.82884668
29MP0002736_abnormal_nociception_after1.81588604
30MP0002184_abnormal_innervation1.79595605
31MP0004885_abnormal_endolymph1.72515153
32MP0003638_abnormal_response/metabolism_1.65274270
33MP0001968_abnormal_touch/_nociception1.64845562
34MP0003879_abnormal_hair_cell1.64219232
35MP0004142_abnormal_muscle_tone1.61195545
36MP0000678_abnormal_parathyroid_gland1.60847827
37MP0002067_abnormal_sensory_capabilities1.58185397
38MP0001970_abnormal_pain_threshold1.57341378
39MP0006276_abnormal_autonomic_nervous1.53700281
40MP0008569_lethality_at_weaning1.49076168
41MP0001440_abnormal_grooming_behavior1.48171762
42MP0002557_abnormal_social/conspecific_i1.46642064
43MP0001542_abnormal_bone_strength1.38898844
44MP0005423_abnormal_somatic_nervous1.38446461
45MP0004134_abnormal_chest_morphology1.33116034
46MP0004084_abnormal_cardiac_muscle1.31183694
47MP0004130_abnormal_muscle_cell1.30904674
48MP0002733_abnormal_thermal_nociception1.28711475
49MP0003183_abnormal_peptide_metabolism1.28653134
50MP0008872_abnormal_physiological_respon1.27177498
51MP0001905_abnormal_dopamine_level1.25815973
52MP0002751_abnormal_autonomic_nervous1.22991259
53MP0010386_abnormal_urinary_bladder1.22761606
54MP0004264_abnormal_extraembryonic_tissu1.21349019
55MP0003329_amyloid_beta_deposits1.21240312
56MP0005409_darkened_coat_color1.17027344
57MP0004270_analgesia1.14780106
58MP0004036_abnormal_muscle_relaxation1.13796456
59MP0001177_atelectasis1.12534477
60MP0002066_abnormal_motor_capabilities/c1.12295667
61MP0002909_abnormal_adrenal_gland1.12098379
62MP0004085_abnormal_heartbeat1.09418326
63MP0002163_abnormal_gland_morphology1.08442967
64MP0003938_abnormal_ear_development1.08183718
65MP0001529_abnormal_vocalization1.04901245
66MP0005379_endocrine/exocrine_gland_phen1.02888006
67MP0002009_preneoplasia1.02358393
68MP0004811_abnormal_neuron_physiology1.01314333
69MP0005167_abnormal_blood-brain_barrier1.00930798
70MP0000639_abnormal_adrenal_gland1.00566402
71MP0006138_congestive_heart_failure0.99787685
72MP0001963_abnormal_hearing_physiology0.99211974
73MP0005171_absent_coat_pigmentation0.99051820
74MP0003632_abnormal_nervous_system0.98867431
75MP0004924_abnormal_behavior0.97966008
76MP0005386_behavior/neurological_phenoty0.97966008
77MP0003123_paternal_imprinting0.97026167
78MP0002882_abnormal_neuron_morphology0.96759941
79MP0001986_abnormal_taste_sensitivity0.95579262
80MP0008877_abnormal_DNA_methylation0.91643614
81MP0002133_abnormal_respiratory_system0.90833678
82MP0005388_respiratory_system_phenotype0.90833678
83MP0008875_abnormal_xenobiotic_pharmacok0.90308326
84MP0000955_abnormal_spinal_cord0.89689989
85MP0003385_abnormal_body_wall0.89561993
86MP0004484_altered_response_of0.88914484
87MP0003075_altered_response_to0.88249718
88MP0002069_abnormal_eating/drinking_beha0.88067770
89MP0003690_abnormal_glial_cell0.87209664
90MP0002332_abnormal_exercise_endurance0.84775913
91MP0001502_abnormal_circadian_rhythm0.84204717
92MP0005620_abnormal_muscle_contractility0.83372996
93MP0003631_nervous_system_phenotype0.83242800
94MP0002108_abnormal_muscle_morphology0.82517986
95MP0000778_abnormal_nervous_system0.82367968
96MP0001984_abnormal_olfaction0.82225978
97MP0003121_genomic_imprinting0.80314581
98MP0001879_abnormal_lymphatic_vessel0.80294691
99MP0008874_decreased_physiological_sensi0.79612224
100MP0005535_abnormal_body_temperature0.78831905
101MP0000003_abnormal_adipose_tissue0.77993740
102MP0005448_abnormal_energy_balance0.77944697
103MP0000230_abnormal_systemic_arterial0.77750119
104MP0001664_abnormal_digestion0.77647979
105MP0003646_muscle_fatigue0.77437575
106MP0000920_abnormal_myelination0.77252288
107MP0000538_abnormal_urinary_bladder0.76358190
108MP0002877_abnormal_melanocyte_morpholog0.74952026
109MP0004742_abnormal_vestibular_system0.74336921
110MP0003633_abnormal_nervous_system0.71764249
111MP0008004_abnormal_stomach_pH0.71457737
112MP0000026_abnormal_inner_ear0.70093594
113MP0002090_abnormal_vision0.69858470
114MP0005645_abnormal_hypothalamus_physiol0.69171883
115MP0005166_decreased_susceptibility_to0.67527773
116MP0000681_abnormal_thyroid_gland0.66694656
117MP0002972_abnormal_cardiac_muscle0.66394956
118MP0002152_abnormal_brain_morphology0.66104343
119MP0001299_abnormal_eye_distance/0.65739338
120MP0002638_abnormal_pupillary_reflex0.65015948
121MP0004019_abnormal_vitamin_homeostasis0.64205441
122MP0009384_cardiac_valve_regurgitation0.64001623
123MP0001485_abnormal_pinna_reflex0.63825064
124MP0002089_abnormal_postnatal_growth/wei0.63591776
125MP0003137_abnormal_impulse_conducting0.63456513
126MP0005551_abnormal_eye_electrophysiolog0.63345053
127MP0001943_abnormal_respiration0.62537035
128MP0004215_abnormal_myocardial_fiber0.62367718
129MP0005670_abnormal_white_adipose0.61936757
130MP0001756_abnormal_urination0.61311257
131MP0005187_abnormal_penis_morphology0.59102293
132MP0010769_abnormal_survival0.57647384
133MP0001765_abnormal_ion_homeostasis0.57608558
134MP0005666_abnormal_adipose_tissue0.57201543
135MP0010768_mortality/aging0.53107084
136MP0003011_delayed_dark_adaptation0.52962004
137MP0010770_preweaning_lethality0.52509258
138MP0002082_postnatal_lethality0.52509258
139MP0002295_abnormal_pulmonary_circulatio0.52058028

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.97619685
2Hyperventilation (HP:0002883)8.32698667
3Atonic seizures (HP:0010819)7.53116553
4Febrile seizures (HP:0002373)6.92114646
5Epileptic encephalopathy (HP:0200134)5.47726243
6Focal seizures (HP:0007359)5.01924721
7Absence seizures (HP:0002121)4.73841221
8Spastic diplegia (HP:0001264)4.63491581
9Action tremor (HP:0002345)4.25081051
10Progressive inability to walk (HP:0002505)4.23886181
11Dialeptic seizures (HP:0011146)4.22216515
12Ankle clonus (HP:0011448)4.14436586
13Growth hormone deficiency (HP:0000824)4.01710184
14Acute necrotizing encephalopathy (HP:0006965)3.98794478
15Abnormal mitochondria in muscle tissue (HP:0008316)3.92579129
16Hyperthyroidism (HP:0000836)3.81417905
17Annular pancreas (HP:0001734)3.75691332
18Progressive macrocephaly (HP:0004481)3.64857450
19Generalized tonic-clonic seizures (HP:0002069)3.45664613
20Abnormality of binocular vision (HP:0011514)3.32976172
21Diplopia (HP:0000651)3.32976172
22Supranuclear gaze palsy (HP:0000605)3.27699623
23Broad-based gait (HP:0002136)3.20838625
24Mitochondrial inheritance (HP:0001427)3.19766717
25Limb dystonia (HP:0002451)3.19189361
26Acute encephalopathy (HP:0006846)3.19038730
27Amblyopia (HP:0000646)3.15731876
28Inability to walk (HP:0002540)3.11801337
29Absent speech (HP:0001344)3.11621798
30Split foot (HP:0001839)3.10806083
31Oligomenorrhea (HP:0000876)3.05603797
32Long foot (HP:0001833)3.03363117
33Esophageal neoplasm (HP:0100751)3.03331738
34Neoplasm of head and neck (HP:0012288)3.03331738
35Abnormal hair whorl (HP:0010721)3.01001919
36Poor suck (HP:0002033)2.93958783
37Large earlobe (HP:0009748)2.91110962
38Pheochromocytoma (HP:0002666)2.90865262
39Lymphangioma (HP:0100764)2.90853439
40Abnormal gallbladder physiology (HP:0012438)2.88346541
41Cholecystitis (HP:0001082)2.88346541
42Polyphagia (HP:0002591)2.87854800
43Neuroendocrine neoplasm (HP:0100634)2.87619251
44Impaired social interactions (HP:0000735)2.87337991
45Abnormal social behavior (HP:0012433)2.87337991
46Submucous cleft hard palate (HP:0000176)2.86532281
47Resting tremor (HP:0002322)2.85370876
48Blue irides (HP:0000635)2.79523781
49Cortical dysplasia (HP:0002539)2.78243545
50Protruding tongue (HP:0010808)2.78079399
51Failure to thrive in infancy (HP:0001531)2.77124400
52Excessive salivation (HP:0003781)2.73564204
53Drooling (HP:0002307)2.73564204
54Neoplasm of the heart (HP:0100544)2.73538666
55Hepatocellular necrosis (HP:0001404)2.73006437
56Increased CSF lactate (HP:0002490)2.71811336
57Increased serum pyruvate (HP:0003542)2.71794337
58Abnormality of glycolysis (HP:0004366)2.71794337
59Torticollis (HP:0000473)2.68213589
60Neoplasm of the peripheral nervous system (HP:0100007)2.67575949
61Hypothermia (HP:0002045)2.66188706
62Papilledema (HP:0001085)2.63904548
63Postural instability (HP:0002172)2.63505240
64Fair hair (HP:0002286)2.57524351
65Intellectual disability, severe (HP:0010864)2.56385360
66Myokymia (HP:0002411)2.52769993
67Epileptiform EEG discharges (HP:0011182)2.52499461
68Delayed gross motor development (HP:0002194)2.52123456
69Abnormality of the labia minora (HP:0012880)2.51800577
70Hypsarrhythmia (HP:0002521)2.50867763
71EEG with generalized epileptiform discharges (HP:0011198)2.50488724
72Oligodontia (HP:0000677)2.46219918
73Neurofibrillary tangles (HP:0002185)2.44970500
74Thyroid-stimulating hormone excess (HP:0002925)2.43647394
75Optic disc pallor (HP:0000543)2.42994756
76Abnormality of the lower motor neuron (HP:0002366)2.40994518
77Thickened helices (HP:0000391)2.40943524
78Visual hallucinations (HP:0002367)2.40106594
79Clonus (HP:0002169)2.39982787
80Rectal prolapse (HP:0002035)2.39810458
81Spastic gait (HP:0002064)2.37058276
82Cerebral edema (HP:0002181)2.36439567
83Macroorchidism (HP:0000053)2.36070548
84Generalized hypopigmentation of hair (HP:0011358)2.34350463
85Urinary bladder sphincter dysfunction (HP:0002839)2.27866130
86Spastic tetraplegia (HP:0002510)2.25756815
87Cupped ear (HP:0000378)2.25656293
88Delusions (HP:0000746)2.25367933
89Coronal craniosynostosis (HP:0004440)2.24659487
90Mutism (HP:0002300)2.23404045
91Narrow nasal bridge (HP:0000446)2.20995548
92Abnormal eating behavior (HP:0100738)2.20895003
93Amyotrophic lateral sclerosis (HP:0007354)2.19934743
94Curly hair (HP:0002212)2.19546732
95Focal dystonia (HP:0004373)2.17150865
96Retinal dysplasia (HP:0007973)2.13800457
97Dysdiadochokinesis (HP:0002075)2.13165526
98Intention tremor (HP:0002080)2.12935224
99Impaired vibration sensation in the lower limbs (HP:0002166)2.12257443
100Poor eye contact (HP:0000817)2.11897010
101Urinary urgency (HP:0000012)2.10551850
102Tetraplegia (HP:0002445)2.09437883
103Lower limb amyotrophy (HP:0007210)2.09412763
104Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.08215735
105Ventricular fibrillation (HP:0001663)2.07516455
106Dysmetria (HP:0001310)2.04922481
107Abnormality of the vocal cords (HP:0008777)2.04557945
108Lower limb muscle weakness (HP:0007340)2.04110083
109Status epilepticus (HP:0002133)2.04029756
110Aortic aneurysm (HP:0004942)2.03211071
111Exercise intolerance (HP:0003546)2.02567345
112Bundle branch block (HP:0011710)2.02149420
113Metabolic alkalosis (HP:0200114)2.02116621
114Leukodystrophy (HP:0002415)2.01459058
115Craniofacial dystonia (HP:0012179)2.01032582
116Gonadal dysgenesis (HP:0000133)2.00577604
117Cutaneous finger syndactyly (HP:0010554)1.99460088
118Medial flaring of the eyebrow (HP:0010747)1.99365296
119X-linked dominant inheritance (HP:0001423)1.99229407
120Hemiplegia (HP:0002301)1.99081715
121Syncope (HP:0001279)1.97593922
122Gaze-evoked nystagmus (HP:0000640)1.97389966
123Short tibia (HP:0005736)1.97083618
124Gait imbalance (HP:0002141)1.96745615
125Flat acetabular roof (HP:0003180)1.95181535
126Hepatic necrosis (HP:0002605)1.92342831
127Deeply set eye (HP:0000490)1.92341184
128Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.91834227
129Sudden death (HP:0001699)1.90811080
130Generalized hypotonia (HP:0001290)1.90191287
131Gait ataxia (HP:0002066)1.90186716
132Esotropia (HP:0000565)1.90000352
133White forelock (HP:0002211)1.89328910
134Cerebral inclusion bodies (HP:0100314)1.88829310
135Abnormality of salivation (HP:0100755)1.86788415
136Prolonged QT interval (HP:0001657)1.85842258
137Gonadotropin excess (HP:0000837)1.84812837
138Truncal ataxia (HP:0002078)1.84272690
139Distal lower limb amyotrophy (HP:0008944)1.83938381
1403-Methylglutaconic aciduria (HP:0003535)1.83789321
141Congenital primary aphakia (HP:0007707)1.81613952
142Lymphedema (HP:0001004)1.81564744
143Intestinal atresia (HP:0011100)1.81263827
144Depression (HP:0000716)1.81056128
145Relative macrocephaly (HP:0004482)1.80380207
146Progressive cerebellar ataxia (HP:0002073)1.80085745
147Respiratory insufficiency due to muscle weakness (HP:0002747)1.79812102
148Generalized myoclonic seizures (HP:0002123)1.79689469
149Asymmetric growth (HP:0100555)1.79442962
150Complete atrioventricular canal defect (HP:0001674)1.78145703
151Hypoplasia of the corpus callosum (HP:0002079)1.78125052
152Agitation (HP:0000713)1.77206750
153Hypogonadotrophic hypogonadism (HP:0000044)1.77182428
154Hyperactive renin-angiotensin system (HP:0000841)1.77121852
155Akinesia (HP:0002304)1.76641809
156Neonatal hypoglycemia (HP:0001998)1.76015313
157Cerebral hypomyelination (HP:0006808)1.75773357
158Anxiety (HP:0000739)1.75752253
159Widely spaced teeth (HP:0000687)1.74444361
160Decreased circulating renin level (HP:0003351)1.73953914
161Respiratory failure (HP:0002878)1.73888948
162Anosmia (HP:0000458)1.73878154
163Abnormality of the periventricular white matter (HP:0002518)1.73628776
164Labial hypoplasia (HP:0000066)1.72714935
165Decreased muscle mass (HP:0003199)1.72076116
166Aplasia/Hypoplasia of the tibia (HP:0005772)1.71553635
167Clumsiness (HP:0002312)1.71494163
168Athetosis (HP:0002305)1.71195663
169Pulmonic stenosis (HP:0001642)1.71055643
170Impaired vibratory sensation (HP:0002495)1.70905118
171Exotropia (HP:0000577)1.70758570
172Oligodactyly (hands) (HP:0001180)1.70590138
173Subaortic stenosis (HP:0001682)1.69721281

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK6.89512913
2ERBB44.09486157
3AKT33.86582405
4NTRK33.69431946
5CAMKK23.15425231
6ACVR1B3.14630540
7MAP2K73.05358059
8MUSK3.00006440
9CAMKK12.79011350
10PDK42.71144183
11PDK32.71144183
12TSSK62.67736974
13MAP3K42.55582953
14MAP3K122.49252080
15CDK82.19496995
16PLK22.09042492
17NTRK22.06475111
18MATK1.89917283
19MAP2K41.85679285
20PDK21.77927438
21PRKCE1.64848266
22PNCK1.64124293
23GRK51.62231732
24EPHA41.61193154
25SIK31.55537487
26RIPK11.47928917
27TYRO31.47788790
28MINK11.45490676
29KIT1.39174718
30PINK11.36599403
31CCNB11.32427844
32PRKCG1.30055271
33DAPK11.23528940
34PKN11.20719265
35CDC42BPA1.18515410
36STK111.09595595
37RPS6KB21.08310068
38CAMK41.07910089
39DAPK31.07735157
40PRPF4B1.04566594
41CAMK2A1.02999329
42MYLK0.99958962
43NME10.96666521
44FGFR20.94224748
45MAP3K70.93987693
46FES0.92979163
47YES10.92562075
48PRKD30.92035931
49SGK20.90540564
50UHMK10.88876858
51MARK10.88171645
52FRK0.87864268
53MST40.86909776
54BRAF0.85971548
55LMTK20.84822269
56ADRBK20.83849290
57SCYL20.82551198
58MAP3K90.80454573
59DMPK0.80428828
60KSR20.79772594
61SGK4940.79300234
62SGK2230.79300234
63FER0.79081440
64SIK20.78086653
65MAP3K60.74950999
66MARK20.74519057
67RET0.73902851
68CDK50.73588781
69CAMK2G0.70572871
70CAMK2B0.70534858
71WNK30.68818972
72CAMK2D0.68431639
73CDK150.65135000
74BCR0.64991327
75SIK10.64104251
76CDK180.63392843
77PRKCZ0.62790283
78PDK10.61326620
79SGK30.58641869
80OXSR10.58478200
81PRKACB0.57908183
82MAP3K130.56556099
83TNIK0.55135449
84CDK11A0.54998333
85CAMK10.54854822
86DDR20.54718596
87PRKCB0.54023469
88PIK3CA0.53083056
89PRKG20.51236708
90MAPK40.50424251
91BMPR1B0.49692650
92MAPKAPK30.49547634
93PRKACA0.49455380
94PRKAA10.47468759
95MAPK70.45972065
96EPHB10.45887505
97PHKG20.45708311
98PHKG10.45708311
99TIE10.45433569
100PTK20.45325563
101FYN0.44163981
102RIPK40.44131589
103EPHA30.43794345
104STK380.42926125
105GRK60.42906680
106PRKCH0.41802727
107ALK0.41176390
108MAPK120.40707839
109RPS6KB10.40238782
110RPS6KA30.40208123
111MAPK130.39568806
112CDK190.39448016
113PDPK10.39310297
114MAP2K60.39055535
115PTK2B0.38931764
116NTRK10.38278694
117SRC0.37944378
118MAPKAPK50.37480000
119INSR0.37230891
120BMPR20.36886287
121LATS20.35976401
122TRPM70.35528678
123CSNK1G20.35332868
124DYRK1A0.34983559
125PAK60.34479925
126ADRBK10.34234678
127PRKCA0.33034908
128MAP2K10.32971024
129ROCK20.31846835
130IGF1R0.30436199
131DAPK20.30290969
132STK160.29573127
133EIF2AK30.28877868
134SGK10.27874009
135ROCK10.25916701
136PRKACG0.24723320
137PRKG10.22815853
138CSNK1G30.22759113
139FGR0.22481803
140PAK30.21723610
141CDK140.20472930
142PLK30.20404455

Predicted pathways (KEGG)

RankGene SetZ-score
1Taurine and hypotaurine metabolism_Homo sapiens_hsa004305.84965060
2Collecting duct acid secretion_Homo sapiens_hsa049664.01994660
3Nicotine addiction_Homo sapiens_hsa050333.66357172
4Synaptic vesicle cycle_Homo sapiens_hsa047213.46811090
5Oxidative phosphorylation_Homo sapiens_hsa001903.19834270
6GABAergic synapse_Homo sapiens_hsa047272.80493596
7Butanoate metabolism_Homo sapiens_hsa006502.76949309
8Type I diabetes mellitus_Homo sapiens_hsa049402.61732314
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.44310358
10Vibrio cholerae infection_Homo sapiens_hsa051102.42647608
11Long-term depression_Homo sapiens_hsa047302.37288913
12Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.19892864
13Morphine addiction_Homo sapiens_hsa050322.18537654
14Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002502.11346182
15Parkinsons disease_Homo sapiens_hsa050121.92106136
16Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.80725103
17Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.72904828
18Alzheimers disease_Homo sapiens_hsa050101.68314819
19Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.60932869
20Circadian entrainment_Homo sapiens_hsa047131.54488013
21Serotonergic synapse_Homo sapiens_hsa047261.53967531
22Rheumatoid arthritis_Homo sapiens_hsa053231.48140204
23Cardiac muscle contraction_Homo sapiens_hsa042601.45989726
24Glutamatergic synapse_Homo sapiens_hsa047241.41102595
25beta-Alanine metabolism_Homo sapiens_hsa004101.32413721
26Taste transduction_Homo sapiens_hsa047421.30129420
27Olfactory transduction_Homo sapiens_hsa047401.30004189
28Dopaminergic synapse_Homo sapiens_hsa047281.25957713
29Phagosome_Homo sapiens_hsa041451.21793657
30Huntingtons disease_Homo sapiens_hsa050161.21707929
312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.21458441
32Long-term potentiation_Homo sapiens_hsa047201.18593945
33Salivary secretion_Homo sapiens_hsa049701.17483107
34Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.15550220
35Cholinergic synapse_Homo sapiens_hsa047251.15038951
36Pyruvate metabolism_Homo sapiens_hsa006201.12907764
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.12421358
38Nitrogen metabolism_Homo sapiens_hsa009101.04449157
39Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.04440683
40Insulin secretion_Homo sapiens_hsa049111.03921901
41Calcium signaling pathway_Homo sapiens_hsa040201.03717256
42Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.03422475
43Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.03052488
44Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.93494259
45Circadian rhythm_Homo sapiens_hsa047100.92650335
46Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.89498281
47Amphetamine addiction_Homo sapiens_hsa050310.88911880
48Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.85588639
49Phospholipase D signaling pathway_Homo sapiens_hsa040720.82365528
50Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.80411040
51Gastric acid secretion_Homo sapiens_hsa049710.79057624
52Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.76609072
53Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.76330356
54Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.74517681
55Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.72081291
56Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.71973323
57Renin secretion_Homo sapiens_hsa049240.71669810
58Melanoma_Homo sapiens_hsa052180.71119712
59Ovarian steroidogenesis_Homo sapiens_hsa049130.71075184
60Dilated cardiomyopathy_Homo sapiens_hsa054140.67757542
61Primary bile acid biosynthesis_Homo sapiens_hsa001200.67340977
62mTOR signaling pathway_Homo sapiens_hsa041500.67102149
63Mineral absorption_Homo sapiens_hsa049780.66786362
64Platelet activation_Homo sapiens_hsa046110.66598954
65Sphingolipid signaling pathway_Homo sapiens_hsa040710.66011567
66Fatty acid elongation_Homo sapiens_hsa000620.65419010
67Dorso-ventral axis formation_Homo sapiens_hsa043200.65349740
68Carbohydrate digestion and absorption_Homo sapiens_hsa049730.62986755
69Glioma_Homo sapiens_hsa052140.62393300
70Oxytocin signaling pathway_Homo sapiens_hsa049210.60069517
71Histidine metabolism_Homo sapiens_hsa003400.59570655
72Aldosterone synthesis and secretion_Homo sapiens_hsa049250.59025819
73Propanoate metabolism_Homo sapiens_hsa006400.58870290
74Arginine and proline metabolism_Homo sapiens_hsa003300.58494043
75Choline metabolism in cancer_Homo sapiens_hsa052310.56778712
76VEGF signaling pathway_Homo sapiens_hsa043700.56606547
77Vitamin B6 metabolism_Homo sapiens_hsa007500.55197693
78Neurotrophin signaling pathway_Homo sapiens_hsa047220.54491185
79Endocytosis_Homo sapiens_hsa041440.53286285
80MAPK signaling pathway_Homo sapiens_hsa040100.53090454
81Inositol phosphate metabolism_Homo sapiens_hsa005620.52594559
82Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.52278560
83Carbon metabolism_Homo sapiens_hsa012000.52081274
84Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.51529856
85Tryptophan metabolism_Homo sapiens_hsa003800.49403270
86Phototransduction_Homo sapiens_hsa047440.47073813
87Vascular smooth muscle contraction_Homo sapiens_hsa042700.46474228
88Melanogenesis_Homo sapiens_hsa049160.44991673
89Thyroid hormone signaling pathway_Homo sapiens_hsa049190.43672387
90cAMP signaling pathway_Homo sapiens_hsa040240.43224147
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42055292
92Axon guidance_Homo sapiens_hsa043600.41183218
93Gap junction_Homo sapiens_hsa045400.40782031
94Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.40364765
95Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.39566238
96Cyanoamino acid metabolism_Homo sapiens_hsa004600.39102638
97Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.37747891
98Tight junction_Homo sapiens_hsa045300.37632391
99Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.36990536
100Alcoholism_Homo sapiens_hsa050340.36778049
101cGMP-PKG signaling pathway_Homo sapiens_hsa040220.36250441
102Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.36225187
103Glucagon signaling pathway_Homo sapiens_hsa049220.36171353
104Regulation of autophagy_Homo sapiens_hsa041400.35321505
105Cysteine and methionine metabolism_Homo sapiens_hsa002700.34687358
106Type II diabetes mellitus_Homo sapiens_hsa049300.33771707
107Protein digestion and absorption_Homo sapiens_hsa049740.33492111
108Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.32637853
109Prion diseases_Homo sapiens_hsa050200.30389150
110Rap1 signaling pathway_Homo sapiens_hsa040150.30125563
111Estrogen signaling pathway_Homo sapiens_hsa049150.30093038
112Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.29257639
113Longevity regulating pathway - mammal_Homo sapiens_hsa042110.28025624
114Tyrosine metabolism_Homo sapiens_hsa003500.27626861
115Cocaine addiction_Homo sapiens_hsa050300.27188016
116Glycerolipid metabolism_Homo sapiens_hsa005610.26229669
117Insulin signaling pathway_Homo sapiens_hsa049100.25855344
118Biosynthesis of amino acids_Homo sapiens_hsa012300.25496927
119Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.25103116
120Oocyte meiosis_Homo sapiens_hsa041140.24388191
121Ras signaling pathway_Homo sapiens_hsa040140.24031247
122Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.23704141
123ErbB signaling pathway_Homo sapiens_hsa040120.23657667
124GnRH signaling pathway_Homo sapiens_hsa049120.22417579
125Thyroid hormone synthesis_Homo sapiens_hsa049180.22298382
126Phenylalanine metabolism_Homo sapiens_hsa003600.20368926
127Proteasome_Homo sapiens_hsa030500.18030085
128Phosphatidylinositol signaling system_Homo sapiens_hsa040700.17398515
129Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.16900527
130Bile secretion_Homo sapiens_hsa049760.16869823
131Arginine biosynthesis_Homo sapiens_hsa002200.15507675
132Metabolic pathways_Homo sapiens_hsa011000.15403821
133Pancreatic secretion_Homo sapiens_hsa049720.13861834
134Renin-angiotensin system_Homo sapiens_hsa046140.12899993
135Sulfur metabolism_Homo sapiens_hsa009200.11924497

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