VIPAS39

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein involved in the sorting of lysosomal proteins. Mutations in this gene are associated with ARCS2 (arthrogryposis, renal dysfunction, and cholestasis-2). Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)9.20834340
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)9.20834340
3regulation of helicase activity (GO:0051095)5.54579141
4keratinocyte development (GO:0003334)5.45811538
5positive regulation of gamma-delta T cell activation (GO:0046645)5.09265969
6positive regulation of mitochondrial fission (GO:0090141)4.80713432
7arginine catabolic process (GO:0006527)4.69354533
8snRNA processing (GO:0016180)4.45435500
9regulation of sarcomere organization (GO:0060297)4.32652185
10snRNA metabolic process (GO:0016073)4.26831985
11regulation of B cell receptor signaling pathway (GO:0050855)4.19912499
12viral protein processing (GO:0019082)4.18961428
13ether lipid metabolic process (GO:0046485)4.18707787
14negative regulation of DNA recombination (GO:0045910)4.10458188
15response to pheromone (GO:0019236)4.06213752
16GMP metabolic process (GO:0046037)4.02303957
17glial cell proliferation (GO:0014009)3.99127832
18lactate metabolic process (GO:0006089)3.98563887
19histone deubiquitination (GO:0016578)3.81087477
20regulation of isotype switching to IgG isotypes (GO:0048302)3.74971840
21pyrimidine dimer repair (GO:0006290)3.72323395
22positive T cell selection (GO:0043368)3.62226292
23ectodermal placode formation (GO:0060788)3.61721637
24antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.46917085
25modulation by symbiont of host immune response (GO:0052553)3.43687310
26positive regulation by symbiont of host defense response (GO:0052509)3.43687310
27modulation by symbiont of host defense response (GO:0052031)3.43687310
28modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.43687310
29modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.43687310
30positive regulation by organism of defense response of other organism involved in symbiotic interact3.43687310
31cellular response to leptin stimulus (GO:0044320)3.38294014
32mitochondrial fragmentation involved in apoptotic process (GO:0043653)3.37414779
33branched-chain amino acid catabolic process (GO:0009083)3.33734394
34COPII vesicle coating (GO:0048208)3.28430009
35regulation of MHC class II biosynthetic process (GO:0045346)3.26966296
36regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.24373153
37removal of superoxide radicals (GO:0019430)3.21795213
38cellular response to superoxide (GO:0071451)3.21795213
39cellular response to oxygen radical (GO:0071450)3.21795213
40synaptic vesicle exocytosis (GO:0016079)3.21740172
41negative regulation of T cell mediated immunity (GO:0002710)3.21700619
42regulation of mitochondrial fission (GO:0090140)3.17825682
43L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.17212415
44positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)3.11883844
45regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.11110942
46mitochondrial fusion (GO:0008053)3.09671424
47proteasome assembly (GO:0043248)3.07675735
48peroxisome fission (GO:0016559)3.07013452
49limb bud formation (GO:0060174)3.05301461
50regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.02557896
51histone H2A acetylation (GO:0043968)3.02474616
52eyelid development in camera-type eye (GO:0061029)3.02459043
53protoporphyrinogen IX biosynthetic process (GO:0006782)3.01713333
54protein heterotetramerization (GO:0051290)3.01161886
55regulation of mitochondrial translation (GO:0070129)3.00241912
56mitochondrial RNA metabolic process (GO:0000959)3.00014721
57protein complex biogenesis (GO:0070271)2.98129716
58negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.97689408
59phagosome maturation (GO:0090382)2.94545272
60regulation of cofactor metabolic process (GO:0051193)2.94254448
61regulation of coenzyme metabolic process (GO:0051196)2.94254448
62negative regulation of T-helper cell differentiation (GO:0045623)2.94020073
63negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.94020073
64positive regulation of glycolytic process (GO:0045821)2.93460713
65regulation of translation in response to stress (GO:0043555)2.89303237
66tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.89288678
67RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.89288678
68acrosome assembly (GO:0001675)2.87665620
69biotin metabolic process (GO:0006768)2.87560622
70regulation of gamma-delta T cell activation (GO:0046643)2.84751663
71nitric oxide mediated signal transduction (GO:0007263)2.83936804
72peptidyl-histidine modification (GO:0018202)2.82243721
73short-chain fatty acid metabolic process (GO:0046459)2.81172928
74regulation of ruffle assembly (GO:1900027)2.80818702
75protein-chromophore linkage (GO:0018298)2.80059827
76rRNA methylation (GO:0031167)2.77647136
77heparin biosynthetic process (GO:0030210)2.77015702
78heparin metabolic process (GO:0030202)2.77015702
79neuron cell-cell adhesion (GO:0007158)2.76573227
80B cell receptor signaling pathway (GO:0050853)2.74633179
81synaptic transmission, glutamatergic (GO:0035249)2.74531152
82ER to Golgi vesicle-mediated transport (GO:0006888)2.72444544
83cellular response to zinc ion (GO:0071294)2.72153184
84negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.71386949
85positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.71371031
86negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.70728874
87negative regulation of ligase activity (GO:0051352)2.70728874
88transferrin transport (GO:0033572)2.70672477
89response to nitrosative stress (GO:0051409)2.70223368
90response to leptin (GO:0044321)2.69590072
91regulation of interferon-beta biosynthetic process (GO:0045357)2.69139723
92regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.67488618
93DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.65484568
94nucleotide-excision repair, DNA damage removal (GO:0000718)2.63458660
95DNA excision (GO:0044349)2.63458660
96protein localization to cilium (GO:0061512)2.63243003
97synaptic vesicle endocytosis (GO:0048488)2.62384918
98ribonucleoprotein complex disassembly (GO:0032988)2.61182308
99branched-chain amino acid metabolic process (GO:0009081)2.61049778
100microglial cell activation (GO:0001774)2.60850349
101response to superoxide (GO:0000303)2.60352953
102COPI coating of Golgi vesicle (GO:0048205)2.60188790
103Golgi transport vesicle coating (GO:0048200)2.60188790
104regulation of acyl-CoA biosynthetic process (GO:0050812)2.60144179
105striatum development (GO:0021756)2.59587168
106signal transduction involved in cell cycle checkpoint (GO:0072395)2.58893481
107histone H4-K5 acetylation (GO:0043981)2.56845790
108histone H4-K8 acetylation (GO:0043982)2.56845790
109regulation of cellular amino acid metabolic process (GO:0006521)2.56744321
110regulation of gamma-delta T cell differentiation (GO:0045586)2.56517877
111response to oxygen radical (GO:0000305)2.56366228
112mitochondrial respiratory chain complex assembly (GO:0033108)2.56348616
113signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.56259994
114intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.56259994
115signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.55589143
116signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.55589143
117signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.55589143
118regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.54854671
119negative regulation of translational initiation (GO:0045947)2.53927499
120ionotropic glutamate receptor signaling pathway (GO:0035235)2.53288189
121ATP hydrolysis coupled proton transport (GO:0015991)2.53159541
122energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.53159541
123positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.52408477
124citrulline metabolic process (GO:0000052)2.52167021
125single strand break repair (GO:0000012)2.51996714
126regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.51533641
127Notch receptor processing (GO:0007220)2.51244263
128peptidyl-cysteine modification (GO:0018198)2.51185857
129positive regulation of protein homooligomerization (GO:0032464)2.50404126
130spermatid nucleus differentiation (GO:0007289)2.49362480
131rRNA modification (GO:0000154)2.48537104
132anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.48252132
133mitotic sister chromatid cohesion (GO:0007064)2.48245135
134ncRNA 3-end processing (GO:0043628)2.48229404
135cardiolipin metabolic process (GO:0032048)2.48212575
136aldehyde catabolic process (GO:0046185)2.48137227
137protein K11-linked ubiquitination (GO:0070979)2.47772079
138glucose 6-phosphate metabolic process (GO:0051156)2.47347741
139cellular response to glucose starvation (GO:0042149)2.47156823
140protein deneddylation (GO:0000338)2.46682639
141L-methionine biosynthetic process (GO:0071265)2.46526726
142amino acid salvage (GO:0043102)2.46526726
143L-methionine salvage (GO:0071267)2.46526726
144mitochondrial fission (GO:0000266)2.46382283
145negative regulation of execution phase of apoptosis (GO:1900118)2.46062437
146heme transport (GO:0015886)2.45891340
147mRNA modification (GO:0016556)2.45551247
148positive regulation of isotype switching (GO:0045830)2.45409128
149purine-containing compound salvage (GO:0043101)2.45259071
150cytochrome complex assembly (GO:0017004)2.45248550
151cullin deneddylation (GO:0010388)2.44830969
152sympathetic nervous system development (GO:0048485)2.44646036
153cilium morphogenesis (GO:0060271)2.44321702
154nitric oxide biosynthetic process (GO:0006809)2.44226415
155negative regulation of stem cell proliferation (GO:2000647)2.43112310
156pyrimidine nucleobase catabolic process (GO:0006208)2.42491550
157ferric iron transport (GO:0015682)2.41069771
158trivalent inorganic cation transport (GO:0072512)2.41069771
159B cell proliferation (GO:0042100)2.38661067
160negative T cell selection (GO:0043383)2.36647033
161negative thymic T cell selection (GO:0045060)2.34059284
162negative regulation of T cell receptor signaling pathway (GO:0050860)2.33959440
163macrophage activation involved in immune response (GO:0002281)2.33413235
164regulation of short-term neuronal synaptic plasticity (GO:0048172)2.32744817
165positive thymic T cell selection (GO:0045059)2.32166827
166neuron recognition (GO:0008038)2.31582809
167T cell migration (GO:0072678)2.31170028
168neuron-neuron synaptic transmission (GO:0007270)2.27246902
169urinary tract smooth muscle contraction (GO:0014848)2.23546577
170negative regulation of lymphocyte mediated immunity (GO:0002707)2.22201749
171phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.21960954
172positive regulation of DNA recombination (GO:0045911)2.21512526
173peptidyl-arginine omega-N-methylation (GO:0035247)2.21044863
174lymphocyte chemotaxis (GO:0048247)2.17504025
175synaptic vesicle docking involved in exocytosis (GO:0016081)2.15860973
176hippocampus development (GO:0021766)2.15305716
177positive regulation of synapse assembly (GO:0051965)2.14568526
178regulation of glutamate receptor signaling pathway (GO:1900449)2.14222205
179inositol phosphate catabolic process (GO:0071545)2.13732397
180postsynaptic membrane organization (GO:0001941)2.13402036
181regulation of ARF protein signal transduction (GO:0032012)2.13249546
182histamine secretion (GO:0001821)2.13055073
183negative regulation of microtubule polymerization (GO:0031115)2.12739077
184regulation of inositol phosphate biosynthetic process (GO:0010919)2.12713246
185neutrophil activation involved in immune response (GO:0002283)2.12648799
186lipopolysaccharide metabolic process (GO:0008653)2.11984818
187cardiovascular system development (GO:0072358)2.11570209
188positive regulation of humoral immune response (GO:0002922)2.09441186
189virion assembly (GO:0019068)2.08503278
190cyclic nucleotide catabolic process (GO:0009214)2.07572412
191regulation of synaptic vesicle exocytosis (GO:2000300)2.06780449
192metanephric mesenchyme development (GO:0072075)2.06685165
193cAMP catabolic process (GO:0006198)2.06478455
194protein localization to synapse (GO:0035418)2.05433179

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat8.61928186
2AR_21572438_ChIP-Seq_LNCaP_Human3.64841457
3EZH2_22144423_ChIP-Seq_EOC_Human3.61072755
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.54552136
5ELF1_17652178_ChIP-ChIP_JURKAT_Human3.45135694
6SALL1_21062744_ChIP-ChIP_HESCs_Human3.40961786
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.40560900
8GBX2_23144817_ChIP-Seq_PC3_Human3.36784130
9BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.15030268
10EST1_17652178_ChIP-ChIP_JURKAT_Human3.03275403
11ZNF274_21170338_ChIP-Seq_K562_Hela2.83003162
12CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.79726675
13ELK1_19687146_ChIP-ChIP_HELA_Human2.77932442
14IRF8_21731497_ChIP-ChIP_J774_Mouse2.71950485
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.54624148
16DCP1A_22483619_ChIP-Seq_HELA_Human2.37718393
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.37044498
18PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.36379930
19VDR_23849224_ChIP-Seq_CD4+_Human2.34851764
20* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.29515072
21PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.26923120
22FOXP3_21729870_ChIP-Seq_TREG_Human2.24979863
23TFEB_21752829_ChIP-Seq_HELA_Human2.22119002
24HOXB4_20404135_ChIP-ChIP_EML_Mouse2.18222304
25ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.16420987
26PADI4_21655091_ChIP-ChIP_MCF-7_Human2.11606250
27KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.06245302
28HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.04519073
29ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.00200013
30GABP_19822575_ChIP-Seq_HepG2_Human1.95433574
31MYCN_18555785_ChIP-Seq_MESCs_Mouse1.91386826
32SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.89053661
33RBPJ_22232070_ChIP-Seq_NCS_Mouse1.87388688
34DROSHA_22980978_ChIP-Seq_HELA_Human1.87103399
35NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.86654519
36SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.86388498
37DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.84967899
38GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.80099053
39CIITA_25753668_ChIP-Seq_RAJI_Human1.72095056
40IGF1R_20145208_ChIP-Seq_DFB_Human1.71847516
41E2F4_17652178_ChIP-ChIP_JURKAT_Human1.70800561
42TP63_19390658_ChIP-ChIP_HaCaT_Human1.70689471
43PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.70106056
44CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.67421625
45REST_21632747_ChIP-Seq_MESCs_Mouse1.67360977
46YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.65645620
47TAF15_26573619_Chip-Seq_HEK293_Human1.65054858
48YY1_21170310_ChIP-Seq_MESCs_Mouse1.63923306
49RARB_27405468_Chip-Seq_BRAIN_Mouse1.63077367
50FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.62751845
51POU3F2_20337985_ChIP-ChIP_501MEL_Human1.61858398
52VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.59089966
53NELFA_20434984_ChIP-Seq_ESCs_Mouse1.57957676
54SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.55796403
55REST_18959480_ChIP-ChIP_MESCs_Mouse1.52181043
56EZH2_27304074_Chip-Seq_ESCs_Mouse1.49518598
57KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.47517474
58SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.46110798
59KDM5A_27292631_Chip-Seq_BREAST_Human1.44682988
60THAP11_20581084_ChIP-Seq_MESCs_Mouse1.43988577
61SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.43868032
62SPI1_23547873_ChIP-Seq_NB4_Human1.42844965
63CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.42744364
64HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.41459282
65CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.39972620
66FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.39754375
67P300_19829295_ChIP-Seq_ESCs_Human1.39231255
68IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.39111382
69NOTCH1_21737748_ChIP-Seq_TLL_Human1.35137794
70ZFP57_27257070_Chip-Seq_ESCs_Mouse1.33512394
71JARID2_20064375_ChIP-Seq_MESCs_Mouse1.32058065
72CTBP2_25329375_ChIP-Seq_LNCAP_Human1.30871974
73SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.30699527
74ZFX_18555785_ChIP-Seq_MESCs_Mouse1.30439763
75SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.29784622
76MYC_19030024_ChIP-ChIP_MESCs_Mouse1.27899522
77TTF2_22483619_ChIP-Seq_HELA_Human1.27869990
78HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.27773718
79FUS_26573619_Chip-Seq_HEK293_Human1.27700052
80ERG_20887958_ChIP-Seq_HPC-7_Mouse1.27204154
81NR3C1_23031785_ChIP-Seq_PC12_Mouse1.26753726
82JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.24980679
83EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.24922294
84OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24267215
85E2F1_18555785_ChIP-Seq_MESCs_Mouse1.23677045
86AR_25329375_ChIP-Seq_VCAP_Human1.23518452
87CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.22978464
88MYC_18555785_ChIP-Seq_MESCs_Mouse1.22812185
89SOX17_20123909_ChIP-Seq_XEN_Mouse1.19143780
90SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.16772686
91CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.14754484
92HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.13851043
93MYC_18358816_ChIP-ChIP_MESCs_Mouse1.13776000
94EZH2_27294783_Chip-Seq_ESCs_Mouse1.13746197
95SOX2_16153702_ChIP-ChIP_HESCs_Human1.12341602
96RNF2_27304074_Chip-Seq_NSC_Mouse1.11734773
97MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.11299327
98SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.10607004
99ER_23166858_ChIP-Seq_MCF-7_Human1.09921733
100SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09789307
101JARID2_20075857_ChIP-Seq_MESCs_Mouse1.09428294
102POU5F1_16153702_ChIP-ChIP_HESCs_Human1.08571109
103ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.07952913
104SMAD4_21799915_ChIP-Seq_A2780_Human1.07434591
105FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.06642594
106RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.06477868
107POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.06463581
108NANOG_16153702_ChIP-ChIP_HESCs_Human1.06315417
109E2F1_21310950_ChIP-Seq_MCF-7_Human1.06266971
110SUZ12_27294783_Chip-Seq_ESCs_Mouse1.06050475
111Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.05330347
112CTBP1_25329375_ChIP-Seq_LNCAP_Human1.04378590
113ELK4_26923725_Chip-Seq_MESODERM_Mouse1.04293809
114EOMES_21245162_ChIP-Seq_HESCs_Human1.03630109
115RNF2_27304074_Chip-Seq_ESCs_Mouse1.02293955
116E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.01465393
117ELF5_23300383_ChIP-Seq_T47D_Human1.00969219
118RNF2_18974828_ChIP-Seq_MESCs_Mouse1.00966267
119EZH2_18974828_ChIP-Seq_MESCs_Mouse1.00966267
120MYB_21317192_ChIP-Seq_ERMYB_Mouse1.00675484
121ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.00326232
122STAT4_19710469_ChIP-ChIP_TH1__Mouse0.99936145
123TOP2B_26459242_ChIP-Seq_MCF-7_Human0.98807327
124SMAD3_21741376_ChIP-Seq_EPCs_Human0.98621362
125TP53_22573176_ChIP-Seq_HFKS_Human0.98559440
126SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.97816233
127TDRD3_21172665_ChIP-Seq_MCF-7_Human0.97026269
128GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.96674730
129STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.95740096
130CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.95709448
131RUNX2_22187159_ChIP-Seq_PCA_Human0.95066086
132BMI1_23680149_ChIP-Seq_NPCS_Mouse0.94646205
133GATA4_21415370_ChIP-Seq_HL-1_Mouse0.94328706
134GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.93258951
135DNAJC2_21179169_ChIP-ChIP_NT2_Human0.93257129
136EED_16625203_ChIP-ChIP_MESCs_Mouse0.93080407
137TCF4_18268006_ChIP-ChIP_LS174T_Human0.93022402
138CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.92704760
139MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.91497844
140MTF2_20144788_ChIP-Seq_MESCs_Mouse0.90998794
141RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.90691324
142IRF1_19129219_ChIP-ChIP_H3396_Human0.90266340
143PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.90089045
144ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.90087624
145NANOG_18555785_Chip-Seq_ESCs_Mouse0.89923719
146MYC_19079543_ChIP-ChIP_MESCs_Mouse0.89906637
147IRF8_27001747_Chip-Seq_BMDM_Mouse0.89849005
148GABP_17652178_ChIP-ChIP_JURKAT_Human0.89010760
149MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.88884439
150SRF_21415370_ChIP-Seq_HL-1_Mouse0.87810117
151BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.87746971
152SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.87562313
153TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.86616533
154SALL4_22934838_ChIP-ChIP_CD34+_Human0.86405633
155NANOG_21062744_ChIP-ChIP_HESCs_Human0.86301184
156PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.85780460
157MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.85695138
158TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.85412512
159NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.85389198
160OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.84907781
161STAT3_23295773_ChIP-Seq_U87_Human0.84774098
162WT1_19549856_ChIP-ChIP_CCG9911_Human0.84654317
163CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.84180284
164CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.83728926
165MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.82592320
166NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.82516358
167CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.79822099
168SOX9_26525672_Chip-Seq_HEART_Mouse0.79258001
169SOX2_21211035_ChIP-Seq_LN229_Gbm0.78964373
170LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.78319912
171SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.78073407
172FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.77875804
173EWS_26573619_Chip-Seq_HEK293_Human0.77387881
174ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.77203933
175RUNX_20019798_ChIP-Seq_JUKART_Human0.75887362

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology6.49566187
2MP0000569_abnormal_digit_pigmentation4.25530098
3MP0003221_abnormal_cardiomyocyte_apopto3.74398093
4MP0008995_early_reproductive_senescence3.37251350
5MP0003880_abnormal_central_pattern3.24203210
6MP0003183_abnormal_peptide_metabolism3.20400006
7MP0005646_abnormal_pituitary_gland3.05428469
8MP0006054_spinal_hemorrhage2.82367227
9MP0005499_abnormal_olfactory_system2.79646350
10MP0005394_taste/olfaction_phenotype2.79646350
11MP0004859_abnormal_synaptic_plasticity2.71970522
12MP0004233_abnormal_muscle_weight2.69955846
13MP0009780_abnormal_chondrocyte_physiolo2.63677998
14MP0003806_abnormal_nucleotide_metabolis2.61230758
15MP0008789_abnormal_olfactory_epithelium2.59743346
16MP0008058_abnormal_DNA_repair2.56260878
17MP0002837_dystrophic_cardiac_calcinosis2.50127464
18MP0000015_abnormal_ear_pigmentation2.45555551
19MP0003172_abnormal_lysosome_physiology2.34210366
20MP0002822_catalepsy2.29302138
21MP0005645_abnormal_hypothalamus_physiol2.23656759
22MP0000372_irregular_coat_pigmentation2.17366180
23MP0003941_abnormal_skin_development2.14998700
24MP0003635_abnormal_synaptic_transmissio2.03383358
25MP0001984_abnormal_olfaction2.01586984
26MP0005171_absent_coat_pigmentation2.00051652
27MP0003786_premature_aging1.94679387
28MP0005257_abnormal_intraocular_pressure1.93314554
29MP0002063_abnormal_learning/memory/cond1.85441409
30MP0005058_abnormal_lysosome_morphology1.82349170
31MP0002064_seizures1.80784428
32MP0001529_abnormal_vocalization1.79501554
33MP0004270_analgesia1.79369715
34MP0003122_maternal_imprinting1.78506133
35MP0008877_abnormal_DNA_methylation1.78398607
36MP0000778_abnormal_nervous_system1.75183110
37MP0002234_abnormal_pharynx_morphology1.74367658
38MP0009840_abnormal_foam_cell1.67499119
39MP0002751_abnormal_autonomic_nervous1.66844271
40MP0002735_abnormal_chemical_nociception1.66152105
41MP0003724_increased_susceptibility_to1.65449553
42MP0009046_muscle_twitch1.63238335
43MP0002572_abnormal_emotion/affect_behav1.61689267
44MP0002009_preneoplasia1.60621862
45MP0009697_abnormal_copulation1.59365888
46MP0010234_abnormal_vibrissa_follicle1.58684329
47MP0003718_maternal_effect1.58224665
48MP0004858_abnormal_nervous_system1.56604001
49MP0009745_abnormal_behavioral_response1.56538179
50MP0002163_abnormal_gland_morphology1.56292462
51MP0010030_abnormal_orbit_morphology1.54742892
52MP0002272_abnormal_nervous_system1.51178055
53MP0003693_abnormal_embryo_hatching1.49609702
54MP0006082_CNS_inflammation1.47757074
55MP0004134_abnormal_chest_morphology1.43720662
56MP0004811_abnormal_neuron_physiology1.41681715
57MP0000920_abnormal_myelination1.40690965
58MP0008569_lethality_at_weaning1.37254061
59MP0006276_abnormal_autonomic_nervous1.35867946
60MP0003634_abnormal_glial_cell1.33549412
61MP0002736_abnormal_nociception_after1.33382946
62MP0001293_anophthalmia1.32062828
63MP0002184_abnormal_innervation1.31632336
64MP0001968_abnormal_touch/_nociception1.31494273
65MP0002697_abnormal_eye_size1.31156414
66MP0002067_abnormal_sensory_capabilities1.29898602
67MP0002557_abnormal_social/conspecific_i1.29866291
68MP0008007_abnormal_cellular_replicative1.27178677
69MP0009765_abnormal_xenobiotic_induced1.26768521
70MP0003656_abnormal_erythrocyte_physiolo1.26010877
71MP0003567_abnormal_fetal_cardiomyocyte1.25177486
72MP0003890_abnormal_embryonic-extraembry1.18595671
73MP0008057_abnormal_DNA_replication1.18207537
74MP0004147_increased_porphyrin_level1.17421758
75MP0003787_abnormal_imprinting1.17408197
76MP0002277_abnormal_respiratory_mucosa1.17181554
77MP0005193_abnormal_anterior_eye1.16637751
78MP0002254_reproductive_system_inflammat1.16013602
79MP0002734_abnormal_mechanical_nocicepti1.14590471
80MP0002127_abnormal_cardiovascular_syste1.12792252
81MP0002090_abnormal_vision1.12770588
82MP0002882_abnormal_neuron_morphology1.10873260
83MP0003111_abnormal_nucleus_morphology1.10558954
84MP0004808_abnormal_hematopoietic_stem1.09994668
85MP0000631_abnormal_neuroendocrine_gland1.09320283
86MP0005367_renal/urinary_system_phenotyp1.09080638
87MP0000516_abnormal_urinary_system1.09080638
88MP0004924_abnormal_behavior1.08115484
89MP0005386_behavior/neurological_phenoty1.08115484
90MP0002095_abnormal_skin_pigmentation1.07323019
91MP0005423_abnormal_somatic_nervous1.05108355
92MP0003763_abnormal_thymus_physiology1.04221081
93MP0001324_abnormal_eye_pigmentation1.03035158
94MP0003121_genomic_imprinting1.01819599
95MP0001727_abnormal_embryo_implantation1.01618080
96MP0005671_abnormal_response_to1.01375672
97MP0003690_abnormal_glial_cell1.01220334
98MP0002233_abnormal_nose_morphology1.01125011
99MP0010386_abnormal_urinary_bladder1.01029491
100MP0005075_abnormal_melanosome_morpholog1.00526343
101MP0008873_increased_physiological_sensi0.99342362
102MP0002269_muscular_atrophy0.99296088
103MP0006035_abnormal_mitochondrial_morpho0.98881273
104MP0008260_abnormal_autophagy0.97990116
105MP0001919_abnormal_reproductive_system0.97869792
106MP0001970_abnormal_pain_threshold0.97195048
107MP0000465_gastrointestinal_hemorrhage0.96680116
108MP0002419_abnormal_innate_immunity0.95746545
109MP0000955_abnormal_spinal_cord0.95559113
110MP0001873_stomach_inflammation0.91291217
111MP0002295_abnormal_pulmonary_circulatio0.91050734
112MP0000647_abnormal_sebaceous_gland0.90447630
113MP0003938_abnormal_ear_development0.88347812
114MP0001963_abnormal_hearing_physiology0.88332919
115MP0001905_abnormal_dopamine_level0.88271136
116MP0000751_myopathy0.87034865
117MP0002152_abnormal_brain_morphology0.85638274
118MP0005310_abnormal_salivary_gland0.84793878
119MP0002733_abnormal_thermal_nociception0.84150870
120MP0002653_abnormal_ependyma_morphology0.83529901
121MP0004957_abnormal_blastocyst_morpholog0.83257823
122MP0002066_abnormal_motor_capabilities/c0.83256865
123MP0001915_intracranial_hemorrhage0.82286205
124MP0003448_altered_tumor_morphology0.80033482
125MP0000358_abnormal_cell_content/0.79586522
126MP0002938_white_spotting0.79436257
127MP0009785_altered_susceptibility_to0.78683327
128MP0000598_abnormal_liver_morphology0.78617638
129MP0003943_abnormal_hepatobiliary_system0.78555539
130MP0005174_abnormal_tail_pigmentation0.78406884
131MP0003866_abnormal_defecation0.78262953
132MP0005379_endocrine/exocrine_gland_phen0.78232846
133MP0003755_abnormal_palate_morphology0.76896299
134MP0009703_decreased_birth_body0.76437693
135MP0000371_diluted_coat_color0.74155102
136MP0001486_abnormal_startle_reflex0.73444859
137MP0002229_neurodegeneration0.73254144
138MP0002405_respiratory_system_inflammati0.73211877
139MP0001835_abnormal_antigen_presentation0.73211075
140MP0001270_distended_abdomen0.71792671
141MP0000490_abnormal_crypts_of0.71640393
142MP0003186_abnormal_redox_activity0.70861098
143MP0002876_abnormal_thyroid_physiology0.70756345
144MP0000049_abnormal_middle_ear0.70754891
145MP0003879_abnormal_hair_cell0.69832252
146MP0001819_abnormal_immune_cell0.69384325
147MP0002420_abnormal_adaptive_immunity0.68432837
148MP0004142_abnormal_muscle_tone0.68184966
149MP0005000_abnormal_immune_tolerance0.68033678
150MP0002148_abnormal_hypersensitivity_rea0.67500900
151MP0000026_abnormal_inner_ear0.67301365
152MP0001243_abnormal_dermal_layer0.67009121
153MP0005408_hypopigmentation0.66682997
154MP0001501_abnormal_sleep_pattern0.66122857
155MP0003935_abnormal_craniofacial_develop0.66118280
156MP0001986_abnormal_taste_sensitivity0.65737241
157MP0000858_altered_metastatic_potential0.65091320
158MP0000681_abnormal_thyroid_gland0.64961316
159MP0002396_abnormal_hematopoietic_system0.64004026
160MP0004133_heterotaxia0.63994652
161MP0006036_abnormal_mitochondrial_physio0.63901291
162MP0005248_abnormal_Harderian_gland0.63486609
163MP0005501_abnormal_skin_physiology0.63026984
164MP0002177_abnormal_outer_ear0.61477650
165MP0002080_prenatal_lethality0.60146392
166MP0005395_other_phenotype0.60048143
167MP0001764_abnormal_homeostasis0.59663977
168MP0002282_abnormal_trachea_morphology0.58634857
169MP0005464_abnormal_platelet_physiology0.58445454
170MP0003191_abnormal_cellular_cholesterol0.58418722
171MP0008872_abnormal_physiological_respon0.58376871
172MP0004185_abnormal_adipocyte_glucose0.58262984
173MP0002092_abnormal_eye_morphology0.57677246

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)6.37575475
2Progressive cerebellar ataxia (HP:0002073)4.56072390
3Neuroendocrine neoplasm (HP:0100634)3.99217236
4Insidious onset (HP:0003587)3.82103922
5Termporal pattern (HP:0011008)3.82103922
6Medulloblastoma (HP:0002885)3.74690325
7True hermaphroditism (HP:0010459)3.72277364
8Central scotoma (HP:0000603)3.65014526
9Ketoacidosis (HP:0001993)3.58745547
10Albinism (HP:0001022)3.56831875
11Pheochromocytoma (HP:0002666)3.53204217
12Progressive sensorineural hearing impairment (HP:0000408)3.43653955
13Peritonitis (HP:0002586)3.35593320
14Pancreatic cysts (HP:0001737)3.23867008
15Gait imbalance (HP:0002141)3.21695332
16Optic neuritis (HP:0100653)3.19931113
17Retrobulbar optic neuritis (HP:0100654)3.19931113
18Intestinal atresia (HP:0011100)3.17812577
19Cortical dysplasia (HP:0002539)3.15342007
20Aplastic anemia (HP:0001915)3.10370855
21Myositis (HP:0100614)3.02907010
22Increased cerebral lipofuscin (HP:0011813)3.02895010
23Congenital primary aphakia (HP:0007707)3.01376559
24Sensory axonal neuropathy (HP:0003390)2.99400692
25Curly hair (HP:0002212)2.98762066
26Methylmalonic acidemia (HP:0002912)2.98049812
27Hyperglycinemia (HP:0002154)2.97996178
28Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.92161423
29Degeneration of the lateral corticospinal tracts (HP:0002314)2.92161423
30Ependymoma (HP:0002888)2.91947778
31Medial flaring of the eyebrow (HP:0010747)2.87112832
32* Nephrogenic diabetes insipidus (HP:0009806)2.83958345
33Hypoplasia of the fovea (HP:0007750)2.83242273
34Aplasia/Hypoplasia of the fovea (HP:0008060)2.83242273
35Abnormality of the pancreatic islet cells (HP:0006476)2.81083434
36Abnormality of endocrine pancreas physiology (HP:0012093)2.81083434
37Increased serum pyruvate (HP:0003542)2.77759261
38Abnormality of glycolysis (HP:0004366)2.77759261
39Hyperammonemia (HP:0001987)2.76574280
40Abnormal delayed hypersensitivity skin test (HP:0002963)2.73492897
41Hypoglycemic seizures (HP:0002173)2.70756522
42Pancreatic fibrosis (HP:0100732)2.69328213
43Neoplasm of the oral cavity (HP:0100649)2.67742904
44Centrally nucleated skeletal muscle fibers (HP:0003687)2.62672519
45Abnormality of serine family amino acid metabolism (HP:0010894)2.60727672
46Abnormality of glycine metabolism (HP:0010895)2.60727672
47Increased neuronal autofluorescent lipopigment (HP:0002074)2.59258243
48Focal motor seizures (HP:0011153)2.56757577
49Orchitis (HP:0100796)2.55641652
50Tinnitus (HP:0000360)2.55561712
51Split foot (HP:0001839)2.54531734
52Abnormality of glycolipid metabolism (HP:0010969)2.52394041
53Abnormality of liposaccharide metabolism (HP:0010968)2.52394041
54Abnormality of glycosphingolipid metabolism (HP:0004343)2.52394041
55Epidermoid cyst (HP:0200040)2.47748656
56Atonic seizures (HP:0010819)2.46684594
57Prominent metopic ridge (HP:0005487)2.46559591
58Myelodysplasia (HP:0002863)2.44319113
59Broad alveolar ridges (HP:0000187)2.43560334
60Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.43477847
61Dyschromatopsia (HP:0007641)2.43349420
62Abnormality of alanine metabolism (HP:0010916)2.42160359
63Hyperalaninemia (HP:0003348)2.42160359
64Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.42160359
65Impaired vibration sensation in the lower limbs (HP:0002166)2.40642079
66Ketosis (HP:0001946)2.39714721
67Epileptic encephalopathy (HP:0200134)2.39381870
68Poor coordination (HP:0002370)2.37116277
69Recurrent abscess formation (HP:0002722)2.36556517
70Abnormal hair whorl (HP:0010721)2.36303588
71Scotoma (HP:0000575)2.36221515
72Abnormal auditory evoked potentials (HP:0006958)2.36080247
73Abnormality of the fovea (HP:0000493)2.35677416
74Fatigue (HP:0012378)2.34375347
75Methylmalonic aciduria (HP:0012120)2.33202869
76Symptomatic seizures (HP:0011145)2.32535221
77Entropion (HP:0000621)2.32341759
78Hepatoblastoma (HP:0002884)2.32113129
79Specific learning disability (HP:0001328)2.31047320
80Progressive hearing impairment (HP:0001730)2.28297725
81Abnormality of the corticospinal tract (HP:0002492)2.26598557
82Microretrognathia (HP:0000308)2.25312962
83Hypokinesia (HP:0002375)2.25045397
84Abnormality of the metopic suture (HP:0005556)2.24607801
85Vaginal atresia (HP:0000148)2.21450621
86Abnormal lung lobation (HP:0002101)2.21295030
87Nephroblastoma (Wilms tumor) (HP:0002667)2.20449897
88Embryonal renal neoplasm (HP:0011794)2.16615219
89Delayed CNS myelination (HP:0002188)2.15990901
90Genital tract atresia (HP:0001827)2.15012446
91Renal Fanconi syndrome (HP:0001994)2.13409965
92Hyperinsulinemic hypoglycemia (HP:0000825)2.12568200
93Thyroid carcinoma (HP:0002890)2.12229245
94Limb dystonia (HP:0002451)2.11551523
95Aplasia/Hypoplasia of the macula (HP:0008059)2.11298542
96Type I transferrin isoform profile (HP:0003642)2.10035718
97Astrocytoma (HP:0009592)2.09313048
98Abnormality of the astrocytes (HP:0100707)2.09313048
99Hypoglycemic coma (HP:0001325)2.08916524
100Abnormality of the peritoneum (HP:0002585)2.08821799
101Hyperglycinuria (HP:0003108)2.06512016
102Hand muscle atrophy (HP:0009130)2.05849188
103Neoplasm of the adrenal gland (HP:0100631)2.04967047
104Increased hepatocellular lipid droplets (HP:0006565)2.04351130
105Abnormality of the labia minora (HP:0012880)2.02771286
106Microvesicular hepatic steatosis (HP:0001414)2.00765395
107Progressive inability to walk (HP:0002505)2.00552878
108Delusions (HP:0000746)2.00414347
1093-Methylglutaconic aciduria (HP:0003535)1.99891862
110Chronic mucocutaneous candidiasis (HP:0002728)1.99064070
111Recurrent cutaneous fungal infections (HP:0011370)1.99064070
112Neoplasm of the peripheral nervous system (HP:0100007)1.98222127
113Annular pancreas (HP:0001734)1.97827129
114Neonatal respiratory distress (HP:0002643)1.97746940
115Sensorimotor neuropathy (HP:0007141)1.96949718
116Loss of speech (HP:0002371)1.96702167
117Abnormality of small intestinal villus morphology (HP:0011472)1.96431177
118Villous atrophy (HP:0011473)1.96431177
119Agnosia (HP:0010524)1.94653848
120Hypoplastic left heart (HP:0004383)1.94440376
121Vacuolated lymphocytes (HP:0001922)1.94268104
122T lymphocytopenia (HP:0005403)1.93109154
123Cerebral hypomyelination (HP:0006808)1.92115294
124Increased IgM level (HP:0003496)1.92049327
125Abnormality of methionine metabolism (HP:0010901)1.91112955
126Leukocytosis (HP:0001974)1.91110538
127Urinary urgency (HP:0000012)1.89358023
128Long clavicles (HP:0000890)1.89349340
129Abnormal pancreas size (HP:0012094)1.89059329
130Abnormality of the vocal cords (HP:0008777)1.88581066
131Mutism (HP:0002300)1.88295719
132Irregular vertebral endplates (HP:0003301)1.87842133
133Shoulder girdle muscle weakness (HP:0003547)1.87612107
134Bifid tongue (HP:0010297)1.86318636
135Failure to thrive in infancy (HP:0001531)1.85016667
136Abnormality of aromatic amino acid family metabolism (HP:0004338)1.84093392
137Abnormality of lateral ventricle (HP:0030047)1.83472301
138Cavernous hemangioma (HP:0001048)1.82982652
139Febrile seizures (HP:0002373)1.81521613
140Poor head control (HP:0002421)1.80391923
141Hepatocellular necrosis (HP:0001404)1.80309693
142Uterine leiomyosarcoma (HP:0002891)1.80252023
143Leiomyosarcoma (HP:0100243)1.80252023
144Aplasia/Hypoplasia affecting the retina (HP:0008061)1.80156037
145Muscular hypotonia of the trunk (HP:0008936)1.80001369
146Progressive external ophthalmoplegia (HP:0000590)1.79611095
147Abnormality of serum amino acid levels (HP:0003112)1.79256863
148Acute necrotizing encephalopathy (HP:0006965)1.78753060
149Amaurosis fugax (HP:0100576)1.76971254
150Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.76905190
151Broad foot (HP:0001769)1.76266033
152Focal seizures (HP:0007359)1.76023797
153Generalized hypopigmentation (HP:0007513)1.74723552
154Cone-rod dystrophy (HP:0000548)1.74686354
155Papillary thyroid carcinoma (HP:0002895)1.74328774
156Polyphagia (HP:0002591)1.74017076
157Hypertensive crisis (HP:0100735)1.72780758
158Hypoplastic pelvis (HP:0008839)1.72146329
159Volvulus (HP:0002580)1.71966753
160Heterochromia iridis (HP:0001100)1.71674671
161Poikiloderma (HP:0001029)1.71022567
162Abnormal mitochondria in muscle tissue (HP:0008316)1.70284956
163Neuroblastic tumors (HP:0004376)1.69863212
164Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.69863212
165Neuroblastoma (HP:0003006)1.69863212
166Primitive neuroectodermal tumor (HP:0030065)1.69863212
167Diastasis recti (HP:0001540)1.69754482
168Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.69656584
169Abnormality of T cell number (HP:0011839)1.69115262
170Acrocyanosis (HP:0001063)1.68607629
171Degeneration of anterior horn cells (HP:0002398)1.67944131
172Abnormality of the anterior horn cell (HP:0006802)1.67944131
173Glioma (HP:0009733)1.67908464
174Hypothermia (HP:0002045)1.67883878
175Recurrent skin infections (HP:0001581)1.67771121
176Hyperventilation (HP:0002883)1.67632852
177Popliteal pterygium (HP:0009756)1.66921100
178Vasculitis (HP:0002633)1.66565489
179Blue irides (HP:0000635)1.66513743
180Deep philtrum (HP:0002002)1.64399638
181Aplasia/Hypoplasia of the lens (HP:0008063)1.64185578
182Supranuclear gaze palsy (HP:0000605)1.63700580
183Single umbilical artery (HP:0001195)1.63255968
184Abnormality of the fetal cardiovascular system (HP:0010948)1.63255968
185Colon cancer (HP:0003003)1.62929936
186Anencephaly (HP:0002323)1.58731157
187Visual hallucinations (HP:0002367)1.58561293

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM287.95361842
2NUAK14.65220359
3MARK12.90013393
4BCKDK2.82908302
5PLK22.65556945
6CCNB12.58206426
7DYRK1B2.35367740
8PRPF4B2.34702877
9CASK2.34062064
10MAP3K122.31632386
11MAPK132.28371464
12SIK32.22257342
13DAPK12.20392331
14TNIK2.17996791
15SGK22.14850571
16TSSK62.04085728
17VRK21.94672927
18SGK4941.94105370
19SGK2231.94105370
20MAP3K31.79867273
21NTRK31.67819593
22MINK11.63502105
23NME21.63185224
24BCR1.62373858
25RPS6KA41.62300763
26IRAK41.56841972
27MAP4K21.53210858
28MAP3K21.51527493
29MAP3K111.49225088
30KSR11.48235191
31DYRK21.48005952
32YES11.47962836
33STK38L1.43503727
34TAF11.43440613
35SRPK11.36372352
36LMTK21.32817803
37OXSR11.32433343
38EPHA41.31006651
39VRK11.29943665
40MAP2K71.29155418
41FES1.28193363
42NME11.26469524
43UHMK11.25985595
44CSNK1A1L1.25794157
45CSNK1G31.25134415
46CAMKK11.24226360
47LIMK11.23514072
48DAPK21.19302948
49STK101.19067633
50PNCK1.18209961
51RPS6KA21.16304718
52FLT31.15779647
53INSRR1.15681641
54ERBB31.11935786
55STK161.11009378
56PLK31.10497730
57MAPKAPK51.09873021
58ITK1.09716029
59CAMKK21.07244071
60MKNK11.07182467
61PKN21.06415563
62CAMK2B1.03255635
63CSNK1G21.03185435
64WNK31.00972885
65SGK31.00768477
66CDK190.97369143
67BMPR20.96010481
68KIT0.92640360
69TESK10.88438629
70FER0.87730224
71MST40.86826947
72EIF2AK30.86629513
73CDK50.84633387
74PRKCE0.80883277
75STK380.80621912
76PBK0.78266873
77DYRK1A0.77146251
78BRSK20.76775673
79ACVR1B0.75971028
80CDK60.75176190
81NTRK20.73879082
82TTK0.73673208
83RAF10.73572273
84TBK10.73424158
85CSNK1A10.72802732
86BRD40.71890469
87LRRK20.71649597
88PTK2B0.70800286
89NEK90.69695298
90PIM20.69562518
91CDK90.68530639
92ADRBK20.68513308
93CSK0.68253843
94FGR0.67623309
95SYK0.67317212
96ZAK0.65009018
97CSNK1G10.64751545
98EIF2AK10.63529367
99HIPK20.62673036
100TLK10.62564488
101CSF1R0.62516946
102MAP2K10.60379724
103MAP3K40.60034076
104CAMK2A0.59769065
105MAP2K60.58586487
106IRAK30.58482942
107AKT30.57840349
108RPS6KA60.57277341
109RPS6KC10.57185549
110RPS6KL10.57185549
111PASK0.57056300
112KSR20.56609656
113PRKCG0.55957454
114PRKCD0.55714652
115MAPK90.55618104
116ROCK20.55105910
117FYN0.54604255
118SCYL20.54039667
119PRKCH0.53123537
120PRKCB0.52251967
121CHEK10.51989262
122RIPK40.50296702
123PRKD20.49764636
124STK40.49758260
125PKN10.49683230
126PAK40.49606061
127ERBB40.49397391
128ILK0.47196753
129ATM0.46881663
130SGK10.46820241
131BMPR1B0.45577433
132RPS6KB10.43325464
133MATK0.43083489
134BUB10.43001871
135NEK60.41871961
136CDK70.41198480
137TNK20.40840045
138DYRK30.40751648
139BTK0.40413202
140MAP2K20.39799656
141FGFR10.39662278
142JAK20.39331675
143CAMK40.38938717
144CDK30.38780766
145CDK140.37768723
146PIM10.37731575
147CDK180.37635764
148TGFBR20.37075347
149MAP3K140.35393934
150PAK60.35152911
151PRKACB0.34639505
152PLK10.33344156
153PRKAA20.32925954
154AKT20.32687520
155CSNK1E0.32609600
156CAMK1G0.32042685
157EPHB20.31115826
158TAOK10.30850872
159CSNK1D0.29562348
160MAP3K50.29384759
161CSNK2A20.28631320

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005244.16612429
2Fatty acid elongation_Homo sapiens_hsa000623.25903715
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.18057323
4Collecting duct acid secretion_Homo sapiens_hsa049662.71500565
5Synaptic vesicle cycle_Homo sapiens_hsa047212.66120662
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.64663802
7Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.64387536
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.62697869
92-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.52383709
10Nicotine addiction_Homo sapiens_hsa050332.18745597
11Vibrio cholerae infection_Homo sapiens_hsa051102.17816295
12Basal transcription factors_Homo sapiens_hsa030222.09019110
13Regulation of autophagy_Homo sapiens_hsa041401.98959676
14Phagosome_Homo sapiens_hsa041451.94419886
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.90742483
16Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.87425308
17Propanoate metabolism_Homo sapiens_hsa006401.83702189
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.80299727
19Sulfur metabolism_Homo sapiens_hsa009201.68363800
20Proteasome_Homo sapiens_hsa030501.66181006
21Lysosome_Homo sapiens_hsa041421.65933818
22SNARE interactions in vesicular transport_Homo sapiens_hsa041301.65093580
23Spliceosome_Homo sapiens_hsa030401.61684219
24Maturity onset diabetes of the young_Homo sapiens_hsa049501.57313474
25Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.54982426
26Glycosaminoglycan degradation_Homo sapiens_hsa005311.54476108
27RNA transport_Homo sapiens_hsa030131.54108185
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.48559215
29Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.46567681
30Carbon metabolism_Homo sapiens_hsa012001.45357793
31Fatty acid metabolism_Homo sapiens_hsa012121.45326687
32Nucleotide excision repair_Homo sapiens_hsa034201.43588003
33Colorectal cancer_Homo sapiens_hsa052101.43568422
34Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.39907678
35Fanconi anemia pathway_Homo sapiens_hsa034601.39290028
36Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.39229444
37Morphine addiction_Homo sapiens_hsa050321.37051999
38Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.36115299
39Circadian entrainment_Homo sapiens_hsa047131.35039124
40Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.34825222
41Axon guidance_Homo sapiens_hsa043601.33712479
42Rheumatoid arthritis_Homo sapiens_hsa053231.32530277
43Olfactory transduction_Homo sapiens_hsa047401.31160327
44B cell receptor signaling pathway_Homo sapiens_hsa046621.29953173
45Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.28761753
46Amphetamine addiction_Homo sapiens_hsa050311.26658862
47Oxidative phosphorylation_Homo sapiens_hsa001901.25751151
48N-Glycan biosynthesis_Homo sapiens_hsa005101.24516813
49Cysteine and methionine metabolism_Homo sapiens_hsa002701.23805885
50mRNA surveillance pathway_Homo sapiens_hsa030151.23634289
51Non-homologous end-joining_Homo sapiens_hsa034501.22640522
52Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.22233898
53Steroid biosynthesis_Homo sapiens_hsa001001.20445990
54Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.20102806
55Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.19493697
56Legionellosis_Homo sapiens_hsa051341.13786795
57Dopaminergic synapse_Homo sapiens_hsa047281.13389670
58Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.13277575
59Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.13155542
60Cocaine addiction_Homo sapiens_hsa050301.11541456
61Long-term potentiation_Homo sapiens_hsa047201.04670362
62Tuberculosis_Homo sapiens_hsa051521.01923335
63Glutamatergic synapse_Homo sapiens_hsa047241.00994804
64Fatty acid degradation_Homo sapiens_hsa000711.00298829
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.99393211
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.98797103
67Taste transduction_Homo sapiens_hsa047420.98185343
68Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.97805438
69Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.97783601
70Circadian rhythm_Homo sapiens_hsa047100.97273231
71Alzheimers disease_Homo sapiens_hsa050100.96871628
72Protein export_Homo sapiens_hsa030600.96180650
73Other glycan degradation_Homo sapiens_hsa005110.94979955
74Galactose metabolism_Homo sapiens_hsa000520.94931164
75GABAergic synapse_Homo sapiens_hsa047270.94762743
76Selenocompound metabolism_Homo sapiens_hsa004500.93874307
77Peroxisome_Homo sapiens_hsa041460.92839875
78Insulin secretion_Homo sapiens_hsa049110.92439261
79Cholinergic synapse_Homo sapiens_hsa047250.91560586
80Cell cycle_Homo sapiens_hsa041100.89909712
81DNA replication_Homo sapiens_hsa030300.88101920
82Neurotrophin signaling pathway_Homo sapiens_hsa047220.86996498
83Endometrial cancer_Homo sapiens_hsa052130.86172101
84Parkinsons disease_Homo sapiens_hsa050120.86146926
85Primary immunodeficiency_Homo sapiens_hsa053400.85873855
86Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.85027005
87T cell receptor signaling pathway_Homo sapiens_hsa046600.84365083
88Phosphatidylinositol signaling system_Homo sapiens_hsa040700.83190421
89Thyroid cancer_Homo sapiens_hsa052160.82161676
90Renin secretion_Homo sapiens_hsa049240.81406149
91Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.80930772
92Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.78320667
93Antigen processing and presentation_Homo sapiens_hsa046120.78252621
94Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.77842168
95Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.76727474
96Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.76721851
97mTOR signaling pathway_Homo sapiens_hsa041500.75047893
98Oocyte meiosis_Homo sapiens_hsa041140.74746312
99Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.74453551
100Butanoate metabolism_Homo sapiens_hsa006500.74214232
101Endocytosis_Homo sapiens_hsa041440.73538767
102Serotonergic synapse_Homo sapiens_hsa047260.73357682
103Shigellosis_Homo sapiens_hsa051310.72297319
104Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.71226982
105Sphingolipid signaling pathway_Homo sapiens_hsa040710.70448032
106Mismatch repair_Homo sapiens_hsa034300.69307407
107Salmonella infection_Homo sapiens_hsa051320.69302908
108Apoptosis_Homo sapiens_hsa042100.68673623
109Sulfur relay system_Homo sapiens_hsa041220.67747980
110Primary bile acid biosynthesis_Homo sapiens_hsa001200.67568589
111Central carbon metabolism in cancer_Homo sapiens_hsa052300.65463961
112Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.64823812
113Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.63712461
114Arginine biosynthesis_Homo sapiens_hsa002200.63622388
115Calcium signaling pathway_Homo sapiens_hsa040200.62585457
116RNA degradation_Homo sapiens_hsa030180.62053553
117Chemokine signaling pathway_Homo sapiens_hsa040620.61744718
118Biosynthesis of amino acids_Homo sapiens_hsa012300.61356676
119Gap junction_Homo sapiens_hsa045400.61183168
120Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60849629
121Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.60486443
122p53 signaling pathway_Homo sapiens_hsa041150.59820721
123Epstein-Barr virus infection_Homo sapiens_hsa051690.59328912
124Toll-like receptor signaling pathway_Homo sapiens_hsa046200.59237489
125Folate biosynthesis_Homo sapiens_hsa007900.58916549
126Osteoclast differentiation_Homo sapiens_hsa043800.58043415
127Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.57727251
128Oxytocin signaling pathway_Homo sapiens_hsa049210.57537562
129Measles_Homo sapiens_hsa051620.56599629
130Huntingtons disease_Homo sapiens_hsa050160.56013652
131Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.55755905
132HIF-1 signaling pathway_Homo sapiens_hsa040660.55458254
133Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.55013100
134Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.54567911
135Fructose and mannose metabolism_Homo sapiens_hsa000510.54423113
136Type I diabetes mellitus_Homo sapiens_hsa049400.53956583
137Sphingolipid metabolism_Homo sapiens_hsa006000.53724335
138Chronic myeloid leukemia_Homo sapiens_hsa052200.52607674
139Viral carcinogenesis_Homo sapiens_hsa052030.52203404
140Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.51424977
141Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50267681
142Glutathione metabolism_Homo sapiens_hsa004800.49178065
143Renin-angiotensin system_Homo sapiens_hsa046140.46929103
144Hepatitis C_Homo sapiens_hsa051600.46262338
145Hepatitis B_Homo sapiens_hsa051610.45901369
146Inositol phosphate metabolism_Homo sapiens_hsa005620.45519882
147Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.45405765
148Glioma_Homo sapiens_hsa052140.44550497
149Non-small cell lung cancer_Homo sapiens_hsa052230.43872219
150Long-term depression_Homo sapiens_hsa047300.43539038
151Influenza A_Homo sapiens_hsa051640.43162790
152Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.43101943
153Renal cell carcinoma_Homo sapiens_hsa052110.41443436
154Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.41284663
155Type II diabetes mellitus_Homo sapiens_hsa049300.40516894
156Aldosterone synthesis and secretion_Homo sapiens_hsa049250.39556387
157Homologous recombination_Homo sapiens_hsa034400.38171361
158Prolactin signaling pathway_Homo sapiens_hsa049170.37863620
159Base excision repair_Homo sapiens_hsa034100.37792513
160Herpes simplex infection_Homo sapiens_hsa051680.36848530
161Transcriptional misregulation in cancer_Homo sapiens_hsa052020.31836467
162Insulin signaling pathway_Homo sapiens_hsa049100.29429550
163Metabolic pathways_Homo sapiens_hsa011000.28525372
164Pancreatic cancer_Homo sapiens_hsa052120.24252066

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