VIPR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a receptor for vasoactive intestinal peptide, a small neuropeptide. Vasoactive intestinal peptide is involved in smooth muscle relaxation, exocrine and endocrine secretion, and water and ion flux in lung and intestinal epithelia. Its actions are effected through integral membrane receptors associated with a guanine nucleotide binding protein which activates adenylate cyclase. Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intestinal cholesterol absorption (GO:0030299)6.38988501
2triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.00658438
3intestinal absorption (GO:0050892)5.94376556
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.50632126
5L-phenylalanine catabolic process (GO:0006559)5.50632126
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.29930712
7L-phenylalanine metabolic process (GO:0006558)5.29930712
8phospholipid efflux (GO:0033700)5.08756361
9high-density lipoprotein particle remodeling (GO:0034375)4.89434237
10aromatic amino acid family catabolic process (GO:0009074)4.83734795
11regulation of cholesterol esterification (GO:0010872)4.79819065
12regulation of triglyceride catabolic process (GO:0010896)4.78570855
13urea metabolic process (GO:0019627)4.70147941
14urea cycle (GO:0000050)4.70147941
15sulfur amino acid catabolic process (GO:0000098)4.63595015
16negative regulation of cholesterol transport (GO:0032375)4.56984511
17negative regulation of sterol transport (GO:0032372)4.56984511
18antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.55659541
19reverse cholesterol transport (GO:0043691)4.54807430
20bile acid and bile salt transport (GO:0015721)4.45101588
21antigen processing and presentation of endogenous antigen (GO:0019883)4.44468194
22alpha-linolenic acid metabolic process (GO:0036109)4.37239667
23antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.36022969
24cholesterol efflux (GO:0033344)4.31453717
25kynurenine metabolic process (GO:0070189)4.30521233
26flavonoid metabolic process (GO:0009812)4.30237337
27drug catabolic process (GO:0042737)4.29665208
28negative regulation of cell killing (GO:0031342)4.28738382
29negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.28738382
30nitrogen cycle metabolic process (GO:0071941)4.26752378
31tryptophan catabolic process (GO:0006569)4.26151216
32indole-containing compound catabolic process (GO:0042436)4.26151216
33indolalkylamine catabolic process (GO:0046218)4.26151216
34regulation of cholesterol homeostasis (GO:2000188)4.23359277
35antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.19433046
36plasma lipoprotein particle remodeling (GO:0034369)4.18914017
37protein-lipid complex remodeling (GO:0034368)4.18914017
38macromolecular complex remodeling (GO:0034367)4.18914017
39plasma lipoprotein particle assembly (GO:0034377)4.18373344
40homocysteine metabolic process (GO:0050667)4.18209301
41cysteine metabolic process (GO:0006534)4.16886985
42regulation of bile acid biosynthetic process (GO:0070857)4.10755368
43bile acid biosynthetic process (GO:0006699)4.08315827
44positive regulation of lipoprotein lipase activity (GO:0051006)4.06028383
45positive regulation of triglyceride lipase activity (GO:0061365)4.06028383
46cellular ketone body metabolic process (GO:0046950)4.05164831
47tryptophan metabolic process (GO:0006568)4.04447942
48bile acid metabolic process (GO:0008206)4.02966220
49acylglycerol homeostasis (GO:0055090)4.01994151
50triglyceride homeostasis (GO:0070328)4.01994151
51protein-lipid complex assembly (GO:0065005)3.83089452
52fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.76853519
53lipoprotein metabolic process (GO:0042157)3.72301900
54cholesterol homeostasis (GO:0042632)3.70349394
55sterol homeostasis (GO:0055092)3.66414570
56phospholipid homeostasis (GO:0055091)3.64965998
57protein carboxylation (GO:0018214)3.64928569
58peptidyl-glutamic acid carboxylation (GO:0017187)3.64928569
59angiotensin maturation (GO:0002003)3.62563111
60complement activation, alternative pathway (GO:0006957)3.62430341
61glyoxylate metabolic process (GO:0046487)3.56791025
62purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.55354191
633-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.55354191
64negative regulation of fibrinolysis (GO:0051918)3.54423123
65positive regulation of lipid catabolic process (GO:0050996)3.53345201
66epoxygenase P450 pathway (GO:0019373)3.51826771
67cellular glucuronidation (GO:0052695)3.49560904
68detection of bacterium (GO:0016045)3.46416707
69ketone body metabolic process (GO:1902224)3.46305535
70drug transmembrane transport (GO:0006855)3.45155809
71positive regulation of gamma-delta T cell activation (GO:0046645)3.44727021
72regulation of fibrinolysis (GO:0051917)3.44389245
73regulation of protein activation cascade (GO:2000257)3.44004363
74aromatic amino acid family metabolic process (GO:0009072)3.43856017
75very-low-density lipoprotein particle assembly (GO:0034379)3.42550444
76UDP-N-acetylglucosamine metabolic process (GO:0006047)3.41349545
77plasma lipoprotein particle clearance (GO:0034381)3.41045406
78regulation of gamma-delta T cell differentiation (GO:0045586)3.40207472
79detection of other organism (GO:0098543)3.40041204
80plasma lipoprotein particle organization (GO:0071827)3.38903249
81lysine metabolic process (GO:0006553)3.38056503
82lysine catabolic process (GO:0006554)3.38056503
83glutamate metabolic process (GO:0006536)3.36639896
84sterol transport (GO:0015918)3.35334817
85cholesterol transport (GO:0030301)3.35334817
86regulation of gamma-delta T cell activation (GO:0046643)3.32989458
87positive regulation of fatty acid biosynthetic process (GO:0045723)3.32984084
88positive regulation of triglyceride metabolic process (GO:0090208)3.29131900
89serine family amino acid catabolic process (GO:0009071)3.27145227
90tyrosine metabolic process (GO:0006570)3.26881775
91amino-acid betaine metabolic process (GO:0006577)3.26761245
92exogenous drug catabolic process (GO:0042738)3.26364481
93cellular modified amino acid catabolic process (GO:0042219)3.26298042
94NADH metabolic process (GO:0006734)3.24570061
95drug metabolic process (GO:0017144)3.23878966
96protein-lipid complex subunit organization (GO:0071825)3.23542931
97regulation of complement activation (GO:0030449)3.19299159
98alpha-amino acid catabolic process (GO:1901606)3.19038881
99surfactant homeostasis (GO:0043129)3.15242662
100negative regulation of erythrocyte differentiation (GO:0045647)3.11320857
101positive regulation of Cdc42 GTPase activity (GO:0043089)3.09747891
102ethanol oxidation (GO:0006069)3.09142939
103cellular amino acid catabolic process (GO:0009063)3.08790214
104lipid homeostasis (GO:0055088)3.08280765
105uronic acid metabolic process (GO:0006063)3.04417512
106glucuronate metabolic process (GO:0019585)3.04417512
107indolalkylamine metabolic process (GO:0006586)3.04016755
108hormone catabolic process (GO:0042447)3.02721913
109diacylglycerol metabolic process (GO:0046339)3.02163593
110short-chain fatty acid metabolic process (GO:0046459)3.01705501
111transcytosis (GO:0045056)3.01627033
112benzene-containing compound metabolic process (GO:0042537)3.01297486
113regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.01293996
114negative regulation of lipase activity (GO:0060192)2.99984529
115pyrimidine nucleoside catabolic process (GO:0046135)2.95680014
116drug transport (GO:0015893)2.94956485
117coenzyme catabolic process (GO:0009109)2.93544059
118ethanol metabolic process (GO:0006067)2.93112514
119cellular response to reactive nitrogen species (GO:1902170)2.92830279
120dicarboxylic acid biosynthetic process (GO:0043650)2.91783702
121phospholipid scrambling (GO:0017121)2.91310285
122response to laminar fluid shear stress (GO:0034616)2.86744892
123renal system process involved in regulation of blood volume (GO:0001977)2.84421949
124thymic T cell selection (GO:0045061)2.83780355
125signal complex assembly (GO:0007172)2.81195480
126regulation of cellular extravasation (GO:0002691)2.80968740
127T cell selection (GO:0045058)2.78857062
128mannose metabolic process (GO:0006013)2.77783477
129regulation of guanylate cyclase activity (GO:0031282)2.77076582
130lipoprotein transport (GO:0042953)2.76906515
131regulation of ARF protein signal transduction (GO:0032012)2.75532512
132positive thymic T cell selection (GO:0045059)2.74282629
133peptide catabolic process (GO:0043171)2.73388489
134regulation of extracellular matrix disassembly (GO:0010715)2.70240781
135negative thymic T cell selection (GO:0045060)2.66563969
136antigen processing and presentation via MHC class Ib (GO:0002475)2.63466094
137modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.61480943
138positive regulation by organism of defense response of other organism involved in symbiotic interact2.61480943
139modulation by symbiont of host immune response (GO:0052553)2.61480943
140positive regulation by symbiont of host defense response (GO:0052509)2.61480943
141modulation by symbiont of host defense response (GO:0052031)2.61480943
142modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.61480943
143peptidyl-tyrosine autophosphorylation (GO:0038083)2.59497650
144negative regulation of lymphocyte mediated immunity (GO:0002707)2.58254945
145negative T cell selection (GO:0043383)2.57497318
146macrophage activation involved in immune response (GO:0002281)2.55087603
147negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.48030745
148cellular response to nitric oxide (GO:0071732)2.47772575
149maintenance of gastrointestinal epithelium (GO:0030277)2.46485670
150multicellular organismal water homeostasis (GO:0050891)2.45965155
151regulation of T-helper 2 cell differentiation (GO:0045628)2.45042103
152positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.43518264
153regulation of dendritic cell antigen processing and presentation (GO:0002604)2.43300896
154regulation of T cell tolerance induction (GO:0002664)2.42928071
155negative regulation of leukocyte mediated immunity (GO:0002704)2.42651721
156dendritic cell chemotaxis (GO:0002407)2.42481220
157positive regulation of Rap GTPase activity (GO:0032854)2.42429746
158neutrophil activation involved in immune response (GO:0002283)2.40959777
159detection of external biotic stimulus (GO:0098581)2.40871061
160positive T cell selection (GO:0043368)2.34804390
161positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.30922773
162positive regulation of fatty acid beta-oxidation (GO:0032000)2.30276688
163negative regulation of glycoprotein biosynthetic process (GO:0010561)2.29884723
164embryonic process involved in female pregnancy (GO:0060136)2.29044097
165leukocyte aggregation (GO:0070486)2.28988404
166regulation of tolerance induction (GO:0002643)2.28250527
167negative regulation of toll-like receptor signaling pathway (GO:0034122)2.27541052
168response to nitric oxide (GO:0071731)2.25661613
169histone H3-K36 demethylation (GO:0070544)2.25399083
170regulation of B cell receptor signaling pathway (GO:0050855)2.24399888
171chemical homeostasis within a tissue (GO:0048875)2.23912817
172fructose metabolic process (GO:0006000)2.23047662
173regulation of systemic arterial blood pressure by hormone (GO:0001990)2.22749801
174regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.22749801
175endocrine process (GO:0050886)2.22749801
176interferon-gamma secretion (GO:0072643)2.22593371
177desmosome organization (GO:0002934)2.21401445
178regulation of leukocyte degranulation (GO:0043300)2.20625295
179negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.18205637
180receptor guanylyl cyclase signaling pathway (GO:0007168)2.17217473
181renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.16278821
182actin filament polymerization (GO:0030041)2.15677311
183leukotriene metabolic process (GO:0006691)2.15446253
184dendritic cell migration (GO:0036336)2.14988955
185response to muramyl dipeptide (GO:0032495)2.11907854
186regulation of regulated secretory pathway (GO:1903305)2.11175002

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.31017797
2RXR_22158963_ChIP-Seq_LIVER_Mouse6.19597111
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.61604614
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.14589917
5EGR1_23403033_ChIP-Seq_LIVER_Mouse4.38129227
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.96832175
7NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.34771011
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.27017998
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.06997085
10SOX2_27498859_Chip-Seq_STOMACH_Mouse2.45860720
11TP63_17297297_ChIP-ChIP_HaCaT_Human2.27308897
12CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.24601507
13KDM2B_26808549_Chip-Seq_SUP-B15_Human2.24338984
14CDX2_20551321_ChIP-Seq_CACO-2_Human2.22753485
15GATA1_22025678_ChIP-Seq_K562_Human2.20154339
16HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.17561481
17TCF7_22412390_ChIP-Seq_EML_Mouse1.97708148
18VDR_21846776_ChIP-Seq_THP-1_Human1.89029211
19VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.81401167
20FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.76908532
21FOXA2_19822575_ChIP-Seq_HepG2_Human1.74291144
22ELK3_25401928_ChIP-Seq_HUVEC_Human1.74177827
23KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.74061646
24KDM2B_26808549_Chip-Seq_DND41_Human1.71882546
25BP1_19119308_ChIP-ChIP_Hs578T_Human1.69784651
26VDR_24763502_ChIP-Seq_THP-1_Human1.68456043
27STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.66804868
28* GATA4_25053715_ChIP-Seq_YYC3_Human1.65362359
29SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.63097139
30TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.62513936
31NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.54755574
32MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.54295144
33CLOCK_20551151_ChIP-Seq_293T_Human1.53072319
34NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.48402858
35IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.46856412
36KDM2B_26808549_Chip-Seq_K562_Human1.46343957
37GATA6_25053715_ChIP-Seq_YYC3_Human1.44448564
38RUNX1_22412390_ChIP-Seq_EML_Mouse1.43738059
39MYC_22102868_ChIP-Seq_BL_Human1.42968687
40TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.42014522
41HNF4A_19822575_ChIP-Seq_HepG2_Human1.40759059
42FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.39524773
43SPI1_23127762_ChIP-Seq_K562_Human1.38712253
44MAF_26560356_Chip-Seq_TH1_Human1.38704779
45ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.36815123
46IRF8_27001747_Chip-Seq_BMDM_Mouse1.36333987
47STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.32549804
48THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.32389095
49ESR2_21235772_ChIP-Seq_MCF-7_Human1.31465287
50FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.28976962
51* SOX2_20726797_ChIP-Seq_SW620_Human1.27976394
52TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26797349
53UTX_26944678_Chip-Seq_JUKART_Human1.24070261
54IRF8_22096565_ChIP-ChIP_GC-B_Human1.23686888
55STAT6_21828071_ChIP-Seq_BEAS2B_Human1.23586572
56IRF8_21731497_ChIP-ChIP_J774_Mouse1.22977536
57BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.22701735
58MYB_21317192_ChIP-Seq_ERMYB_Mouse1.22691778
59STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.21046948
60FOXO3_23340844_ChIP-Seq_DLD1_Human1.20980985
61SMC4_20622854_ChIP-Seq_HELA_Human1.19697455
62BRD4_27068464_Chip-Seq_AML-cells_Mouse1.19031836
63KDM2B_26808549_Chip-Seq_JURKAT_Human1.18498859
64RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.18023354
65CTCF_27219007_Chip-Seq_ERYTHROID_Human1.16231241
66AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.15649752
67P63_26484246_Chip-Seq_KERATINOCYTES_Human1.15375601
68GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13625155
69* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13275031
70SCL_19346495_ChIP-Seq_HPC-7_Human1.13111420
71SA1_27219007_Chip-Seq_ERYTHROID_Human1.11657153
72BCOR_27268052_Chip-Seq_Bcells_Human1.11403788
73CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11399269
74TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.10134027
75EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.09447865
76LXR_22292898_ChIP-Seq_THP-1_Human1.08752423
77PPAR_26484153_Chip-Seq_NCI-H1993_Human1.07877999
78P68_20966046_ChIP-Seq_HELA_Human1.07667436
79SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.07529767
80MAF_26560356_Chip-Seq_TH2_Human1.06441311
81* TET1_21451524_ChIP-Seq_MESCs_Mouse1.06293974
82PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03269563
83* KLF5_25053715_ChIP-Seq_YYC3_Human1.02956259
84GATA1_22383799_ChIP-Seq_G1ME_Mouse1.02313339
85RACK7_27058665_Chip-Seq_MCF-7_Human1.02139324
86BCL6_27268052_Chip-Seq_Bcells_Human1.02137168
87PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.01176817
88MYB_26560356_Chip-Seq_TH1_Human1.00358123
89ESR1_21235772_ChIP-Seq_MCF-7_Human1.00304237
90ZNF263_19887448_ChIP-Seq_K562_Human1.00204763
91ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.99209133
92FOXA1_25552417_ChIP-Seq_VCAP_Human0.99037915
93ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98069665
94ZNF217_24962896_ChIP-Seq_MCF-7_Human0.96880118
95RUNX1_27514584_Chip-Seq_MCF-7_Human0.94494013
96GATA2_19941826_ChIP-Seq_K562_Human0.94342667
97FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.93918815
98GATA1_19941826_ChIP-Seq_K562_Human0.93766039
99CDX2_19796622_ChIP-Seq_MESCs_Mouse0.92010020
100* CREB1_26743006_Chip-Seq_LNCaP_Human0.91314514
101RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.87337189
102MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.85747740
103NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.82898519
104KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.82148202
105KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.81857250
106HTT_18923047_ChIP-ChIP_STHdh_Human0.81772558
107E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.79539739
108ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.78910002
109PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.77937533
110SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.77843269
111FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.76721517
112BCAT_22108803_ChIP-Seq_LS180_Human0.76284759
113FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.75481607
114STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.73814327
115SRY_22984422_ChIP-ChIP_TESTIS_Rat0.73432161
116BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.72902601
117CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.72698217
118PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.72687911
119RARA_24833708_ChIP-Seq_LIVER_Mouse0.71846796
120EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.70614441
121FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.70463214
122NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.69606543
123EGR1_19032775_ChIP-ChIP_M12_Human0.69527330
124ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.69427814
125Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.69334838
126GATA3_24758297_ChIP-Seq_MCF-7_Human0.68337863
127GATA1_19941827_ChIP-Seq_MEL_Mouse0.65995790
128DNAJC2_21179169_ChIP-ChIP_NT2_Human0.65198308
129SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.64863277
130* DROSHA_22980978_ChIP-Seq_HELA_Human0.64281255
131MYC_19915707_ChIP-ChIP_AK7_Human0.64196646
132RXRA_24833708_ChIP-Seq_LIVER_Mouse0.62863748
133ATF3_27146783_Chip-Seq_COLON_Human0.62691801
134ESR1_20079471_ChIP-ChIP_T-47D_Human0.62074088
135SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.61353424
136KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.60801838
137CTCF_27219007_Chip-Seq_Bcells_Human0.60432356
138GATA2_21666600_ChIP-Seq_HMVEC_Human0.59800830
139ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.58710941
140EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.58384925
141RARB_24833708_ChIP-Seq_LIVER_Mouse0.57255904
142JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.57148744
143RARG_19884340_ChIP-ChIP_MEFs_Mouse0.56930267
144RUNX_20019798_ChIP-Seq_JUKART_Human0.55823944
145TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.55809490
146CTNNB1_20460455_ChIP-Seq_HCT116_Human0.54938776
147NRF2_20460467_ChIP-Seq_MEFs_Mouse0.54918901
148NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.54918901
149RXR_22108803_ChIP-Seq_LS180_Human0.54713577

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis7.57175881
2MP0002139_abnormal_hepatobiliary_system6.61113143
3MP0005085_abnormal_gallbladder_physiolo5.39294595
4MP0005365_abnormal_bile_salt5.15721885
5MP0008875_abnormal_xenobiotic_pharmacok4.34371049
6MP0001666_abnormal_nutrient_absorption4.16393702
7MP0003252_abnormal_bile_duct3.95044482
8MP0009840_abnormal_foam_cell3.36237756
9MP0010329_abnormal_lipoprotein_level3.24173452
10MP0003724_increased_susceptibility_to3.07918572
11MP0003806_abnormal_nucleotide_metabolis2.91960472
12MP0010234_abnormal_vibrissa_follicle2.70399394
13MP0003436_decreased_susceptibility_to2.44331878
14MP0004782_abnormal_surfactant_physiolog2.19676129
15MP0005083_abnormal_biliary_tract2.14169191
16MP0003191_abnormal_cellular_cholesterol2.11098535
17MP0002822_catalepsy2.08551601
18MP0005332_abnormal_amino_acid2.08545300
19MP0003195_calcinosis2.06926264
20MP0003868_abnormal_feces_composition1.98109238
21MP0004264_abnormal_extraembryonic_tissu1.96638565
22MP0004019_abnormal_vitamin_homeostasis1.95123436
23MP0000609_abnormal_liver_physiology1.94813345
24MP0003303_peritoneal_inflammation1.93334787
25MP0003763_abnormal_thymus_physiology1.93215439
26MP0002118_abnormal_lipid_homeostasis1.88321237
27MP0003300_gastrointestinal_ulcer1.82640157
28MP0002138_abnormal_hepatobiliary_system1.78662254
29MP0005025_abnormal_response_to1.66709608
30MP0003183_abnormal_peptide_metabolism1.62226535
31MP0005409_darkened_coat_color1.61083423
32MP0003866_abnormal_defecation1.58226157
33MP0001835_abnormal_antigen_presentation1.58008570
34MP0004043_abnormal_pH_regulation1.56860012
35MP0005387_immune_system_phenotype1.53421978
36MP0001790_abnormal_immune_system1.53421978
37MP0009643_abnormal_urine_homeostasis1.51929231
38MP0001800_abnormal_humoral_immune1.49308144
39MP0002009_preneoplasia1.44985477
40MP0002419_abnormal_innate_immunity1.43646136
41MP0005319_abnormal_enzyme/_coenzyme1.40336122
42MP0005000_abnormal_immune_tolerance1.39944840
43MP0009780_abnormal_chondrocyte_physiolo1.37978913
44MP0009785_altered_susceptibility_to1.36438398
45MP0008260_abnormal_autophagy1.33802641
46MP0003705_abnormal_hypodermis_morpholog1.29352987
47MP0000465_gastrointestinal_hemorrhage1.29244943
48MP0001851_eye_inflammation1.29064248
49MP0003828_pulmonary_edema1.27656276
50MP0002723_abnormal_immune_serum1.27123414
51MP0000462_abnormal_digestive_system1.26595504
52MP0001533_abnormal_skeleton_physiology1.25293747
53MP0001819_abnormal_immune_cell1.25255778
54MP0002420_abnormal_adaptive_immunity1.24780710
55MP0001873_stomach_inflammation1.21628555
56MP0003045_fibrosis1.21191501
57MP0008004_abnormal_stomach_pH1.21168463
58MP0002254_reproductive_system_inflammat1.21094229
59MP0005584_abnormal_enzyme/coenzyme_acti1.20380402
60MP0009379_abnormal_foot_pigmentation1.20215941
61MP0000490_abnormal_crypts_of1.19433852
62MP0002452_abnormal_antigen_presenting1.18046235
63MP0009333_abnormal_splenocyte_physiolog1.16600163
64MP0006082_CNS_inflammation1.14684100
65MP0001764_abnormal_homeostasis1.14552888
66MP0005636_abnormal_mineral_homeostasis1.14454148
67MP0005058_abnormal_lysosome_morphology1.13624325
68MP0001501_abnormal_sleep_pattern1.13453734
69MP0002078_abnormal_glucose_homeostasis1.13272652
70MP0000685_abnormal_immune_system1.12393033
71MP0001765_abnormal_ion_homeostasis1.11918263
72MP0005671_abnormal_response_to1.11483785
73MP0010155_abnormal_intestine_physiology1.11432737
74MP0003690_abnormal_glial_cell1.10700707
75MP0005448_abnormal_energy_balance1.09141917
76MP0001958_emphysema1.07103831
77MP0002909_abnormal_adrenal_gland1.07002790
78MP0005501_abnormal_skin_physiology1.03160274
79MP0002693_abnormal_pancreas_physiology1.02812987
80MP0002998_abnormal_bone_remodeling1.01556219
81MP0004510_myositis1.01257138
82MP0004381_abnormal_hair_follicle1.00902492
83MP0002148_abnormal_hypersensitivity_rea1.00651200
84MP0005220_abnormal_exocrine_pancreas1.00424762
85MP0005084_abnormal_gallbladder_morpholo0.99519119
86MP0002098_abnormal_vibrissa_morphology0.99456523
87MP0004858_abnormal_nervous_system0.99081984
88MP0001663_abnormal_digestive_system0.98346265
89MP0000858_altered_metastatic_potential0.97651773
90MP0002006_tumorigenesis0.97492002
91MP0002405_respiratory_system_inflammati0.97190959
92MP0003091_abnormal_cell_migration0.97133141
93MP0005451_abnormal_body_composition0.95830107
94MP0002132_abnormal_respiratory_system0.95782722
95MP0005381_digestive/alimentary_phenotyp0.95358866
96MP0005076_abnormal_cell_differentiation0.95308417
97MP0000249_abnormal_blood_vessel0.94921537
98MP0003283_abnormal_digestive_organ0.93616539
99MP0001944_abnormal_pancreas_morphology0.93160751
100MP0008961_abnormal_basal_metabolism0.92179582
101MP0000604_amyloidosis0.91206410
102MP0009642_abnormal_blood_homeostasis0.90653761
103MP0000716_abnormal_immune_system0.89313739
104MP0001756_abnormal_urination0.87481949
105MP0003172_abnormal_lysosome_physiology0.87257858
106MP0004883_abnormal_blood_vessel0.87130454
107MP0009697_abnormal_copulation0.85138504
108MP0002876_abnormal_thyroid_physiology0.84646838
109MP0000598_abnormal_liver_morphology0.82501370
110MP0001664_abnormal_digestion0.76843960
111MP0005535_abnormal_body_temperature0.75910467
112MP0000538_abnormal_urinary_bladder0.75690027
113MP0008469_abnormal_protein_level0.75229479
114MP0000477_abnormal_intestine_morphology0.74702410
115MP0004947_skin_inflammation0.74155410
116MP0002796_impaired_skin_barrier0.70948037
117MP0005334_abnormal_fat_pad0.70608233
118MP0003953_abnormal_hormone_level0.70337238
119MP0005166_decreased_susceptibility_to0.65789060
120MP0009765_abnormal_xenobiotic_induced0.65486366
121MP0005310_abnormal_salivary_gland0.65319986
122MP0009764_decreased_sensitivity_to0.65308593
123MP0000013_abnormal_adipose_tissue0.64185901
124MP0005379_endocrine/exocrine_gland_phen0.63117080
125MP0002971_abnormal_brown_adipose0.62806331
126MP0008872_abnormal_physiological_respon0.61511606
127MP0002136_abnormal_kidney_physiology0.60758202
128MP0005464_abnormal_platelet_physiology0.59716650
129MP0003656_abnormal_erythrocyte_physiolo0.59436696
130MP0001881_abnormal_mammary_gland0.58279731
131MP0005167_abnormal_blood-brain_barrier0.57540345
132MP0000230_abnormal_systemic_arterial0.55118931
133MP0009763_increased_sensitivity_to0.54689232
134MP0005266_abnormal_metabolism0.53956579
135MP0001845_abnormal_inflammatory_respons0.53529065
136MP0003075_altered_response_to0.53182895
137MP0005376_homeostasis/metabolism_phenot0.52277597
138MP0003329_amyloid_beta_deposits0.52094451
139MP0002166_altered_tumor_susceptibility0.51822871
140MP0010352_gastrointestinal_tract_polyps0.51018377
141MP0004185_abnormal_adipocyte_glucose0.50743882
142MP0003879_abnormal_hair_cell0.49756229
143MP0005408_hypopigmentation0.48971336
144MP0002837_dystrophic_cardiac_calcinosis0.48893365
145MP0005670_abnormal_white_adipose0.48805243
146MP0003453_abnormal_keratinocyte_physiol0.48487999
147MP0002877_abnormal_melanocyte_morpholog0.47469778
148MP0004130_abnormal_muscle_cell0.46343452
149MP0005647_abnormal_sex_gland0.45137384
150MP0008873_increased_physiological_sensi0.44740779
151MP0000678_abnormal_parathyroid_gland0.44093158
152MP0005666_abnormal_adipose_tissue0.44008560
153MP0002928_abnormal_bile_duct0.43286697

Predicted human phenotypes

RankGene SetZ-score
1Hypobetalipoproteinemia (HP:0003563)6.08367002
2Intrahepatic cholestasis (HP:0001406)5.96618360
3Abnormality of aromatic amino acid family metabolism (HP:0004338)5.81381723
4Abnormality of monocarboxylic acid metabolism (HP:0010996)5.45579976
5Eczematoid dermatitis (HP:0000976)5.44006404
6Xanthomatosis (HP:0000991)5.20476751
7Deep venous thrombosis (HP:0002625)5.02337877
8Conjugated hyperbilirubinemia (HP:0002908)4.64291352
9Abnormality of glutamine family amino acid metabolism (HP:0010902)4.57561441
10Prolonged partial thromboplastin time (HP:0003645)4.53640161
11Hypoglycemic coma (HP:0001325)4.40286045
12Fat malabsorption (HP:0002630)4.29348914
13Hypolipoproteinemia (HP:0010981)4.16341359
14Hyperactive renin-angiotensin system (HP:0000841)3.86908913
15Ketosis (HP:0001946)3.84219964
16Interstitial pulmonary disease (HP:0006530)3.83659676
17Ketoacidosis (HP:0001993)3.76878912
18Acanthocytosis (HP:0001927)3.74362488
19Hyperinsulinemic hypoglycemia (HP:0000825)3.72279835
20Hyperlipoproteinemia (HP:0010980)3.70624368
21Epidermoid cyst (HP:0200040)3.67535426
22Complement deficiency (HP:0004431)3.64984070
23Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.64323682
24Hypoglycemic seizures (HP:0002173)3.60119492
25Abnormality of the common coagulation pathway (HP:0010990)3.58725313
26Hyperammonemia (HP:0001987)3.53874537
27Abnormality of sulfur amino acid metabolism (HP:0004339)3.51181538
28Ileus (HP:0002595)3.43974696
29Malnutrition (HP:0004395)3.42169618
30Hyperglycinuria (HP:0003108)3.40628961
31Abnormality of the intrinsic pathway (HP:0010989)3.34633920
32Recurrent abscess formation (HP:0002722)3.22545575
33Abnormality of aspartate family amino acid metabolism (HP:0010899)3.21751231
34Symptomatic seizures (HP:0011145)3.21206634
35Decreased circulating renin level (HP:0003351)3.14536826
36Hypoalphalipoproteinemia (HP:0003233)3.02987356
37Hypercholesterolemia (HP:0003124)3.01906394
38Late onset (HP:0003584)3.01285662
39Abnormality of glycine metabolism (HP:0010895)2.99717555
40Abnormality of serine family amino acid metabolism (HP:0010894)2.99717555
41Hemorrhage of the eye (HP:0011885)2.99403097
42Hyperbilirubinemia (HP:0002904)2.97450448
43Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.95206903
44Joint hemorrhage (HP:0005261)2.83600386
45Flat acetabular roof (HP:0003180)2.82482412
46Recurrent bacterial skin infections (HP:0005406)2.82109980
47Abnormality of macrophages (HP:0004311)2.79376778
48Spontaneous hematomas (HP:0007420)2.79213235
49Gingivitis (HP:0000230)2.78930627
50Abnormality of purine metabolism (HP:0004352)2.78604036
51Hyperglycemia (HP:0003074)2.77687364
52Recurrent gram-negative bacterial infections (HP:0005420)2.76536695
53Growth hormone excess (HP:0000845)2.76407979
54Hyperglycinemia (HP:0002154)2.76010100
55Increased IgE level (HP:0003212)2.73051083
56Abdominal distention (HP:0003270)2.70174842
57Thin bony cortex (HP:0002753)2.69897545
58Myositis (HP:0100614)2.69498345
59Abnormality of proline metabolism (HP:0010907)2.63648299
60Hydroxyprolinuria (HP:0003080)2.63648299
61Abnormality of fatty-acid metabolism (HP:0004359)2.61707165
62Sensorimotor neuropathy (HP:0007141)2.60958988
63Abnormality of the fingertips (HP:0001211)2.60404107
64Abnormality of complement system (HP:0005339)2.58651566
65Segmental peripheral demyelination/remyelination (HP:0003481)2.58536434
66Abnormality of methionine metabolism (HP:0010901)2.56514711
67Metabolic acidosis (HP:0001942)2.53755328
68Abnormality of renin-angiotensin system (HP:0000847)2.53734922
69Abnormality of nucleobase metabolism (HP:0010932)2.53494456
70Skin nodule (HP:0200036)2.52742360
71Obstructive sleep apnea (HP:0002870)2.51946954
72Steatorrhea (HP:0002570)2.51254419
73Elevated erythrocyte sedimentation rate (HP:0003565)2.49063304
74Papilledema (HP:0001085)2.45204008
75Widely patent fontanelles and sutures (HP:0004492)2.43778442
76Colitis (HP:0002583)2.43622121
77Abnormality of endocrine pancreas physiology (HP:0012093)2.43542574
78Abnormality of the pancreatic islet cells (HP:0006476)2.43542574
79Metabolic alkalosis (HP:0200114)2.43243928
80Myocardial infarction (HP:0001658)2.40612212
81Orchitis (HP:0100796)2.38444639
82Gastrointestinal inflammation (HP:0004386)2.37422247
83Pustule (HP:0200039)2.36047758
84Right ventricular cardiomyopathy (HP:0011663)2.34930114
85Inflammation of the large intestine (HP:0002037)2.32014286
86Pili torti (HP:0003777)2.28450963
87Poikilocytosis (HP:0004447)2.27441173
88Autoimmune thrombocytopenia (HP:0001973)2.25264139
89Spontaneous abortion (HP:0005268)2.24872874
90Abnormal tarsal ossification (HP:0008369)2.24466640
91Pancreatitis (HP:0001733)2.24226397
92Irritability (HP:0000737)2.23291796
93Ankle clonus (HP:0011448)2.20727910
94Cellulitis (HP:0100658)2.17266566
95Gout (HP:0001997)2.14856743
96Hepatocellular carcinoma (HP:0001402)2.14608744
97Chronic diarrhea (HP:0002028)2.14542096
98Gastrointestinal infarctions (HP:0005244)2.14348557
99Abnormality of dicarboxylic acid metabolism (HP:0010995)2.13247926
100Dicarboxylic aciduria (HP:0003215)2.13247926
101Generalized aminoaciduria (HP:0002909)2.09744471
102Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.09733101
103Pancreatic islet-cell hyperplasia (HP:0004510)2.06920135
104Abnormal gallbladder physiology (HP:0012438)2.05702634
105Cholecystitis (HP:0001082)2.05702634
106Abnormal gallbladder morphology (HP:0012437)2.05514209
107Alkalosis (HP:0001948)2.04538028
108Esophageal varix (HP:0002040)2.03680148
109Axonal loss (HP:0003447)2.03401280
110Abnormality of pyrimidine metabolism (HP:0004353)2.03275296
111Prolonged bleeding time (HP:0003010)1.99231490
112Polycythemia (HP:0001901)1.98987843
113Abnormality of urine glucose concentration (HP:0011016)1.97684546
114Glycosuria (HP:0003076)1.97684546
115Meningitis (HP:0001287)1.96428331
116Acute hepatic failure (HP:0006554)1.96019541
117Recurrent fungal infections (HP:0002841)1.94482911
118Vasculitis (HP:0002633)1.92398712
119Polygenic inheritance (HP:0010982)1.92233399
120Seborrheic dermatitis (HP:0001051)1.91796635
121Gastrointestinal dysmotility (HP:0002579)1.90479008
122Nephrolithiasis (HP:0000787)1.90413952
123Cholelithiasis (HP:0001081)1.90112145
124Abnormality of vitamin metabolism (HP:0100508)1.89943801
125Visceral angiomatosis (HP:0100761)1.89926314
126Broad face (HP:0000283)1.89735601
127Protuberant abdomen (HP:0001538)1.89175234
128Retrobulbar optic neuritis (HP:0100654)1.88678250
129Optic neuritis (HP:0100653)1.88678250
130Gingival bleeding (HP:0000225)1.88578982
131Pigmentary retinal degeneration (HP:0001146)1.87928477
132Abnormality of the distal phalanx of the thumb (HP:0009617)1.87370497
133Onion bulb formation (HP:0003383)1.86810267
134Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.86674659
135Ventricular fibrillation (HP:0001663)1.86026529
136Vascular calcification (HP:0004934)1.85296481
137Hyperparathyroidism (HP:0000843)1.84928207
138Amyloidosis (HP:0011034)1.84376832
139Menorrhagia (HP:0000132)1.84020398
140Delayed CNS myelination (HP:0002188)1.83380049
141Hypertriglyceridemia (HP:0002155)1.83341028
142Glomerulonephritis (HP:0000099)1.83229381
143Lethargy (HP:0001254)1.82313833
144Alveolar cell carcinoma (HP:0006519)1.81652372
145Abnormality of chloride homeostasis (HP:0011422)1.81544193
146Nephritis (HP:0000123)1.81018440
147Abnormal delayed hypersensitivity skin test (HP:0002963)1.80784620
148Insulin resistance (HP:0000855)1.79439973
149Chronic obstructive pulmonary disease (HP:0006510)1.79209874
150Obstructive lung disease (HP:0006536)1.79209874
151Recurrent skin infections (HP:0001581)1.79135804
152Bone pain (HP:0002653)1.78594914
153Urinary glycosaminoglycan excretion (HP:0003541)1.78426894
154Mucopolysacchariduria (HP:0008155)1.78426894
155Autoimmune hemolytic anemia (HP:0001890)1.78110072
156Abnormal enzyme/coenzyme activity (HP:0012379)1.77887451
157Osteomyelitis (HP:0002754)1.77193326
158Spastic diplegia (HP:0001264)1.76876473
159Systemic lupus erythematosus (HP:0002725)1.76843230
160Verrucae (HP:0200043)1.76514124
161Papilloma (HP:0012740)1.76514124
162Slow saccadic eye movements (HP:0000514)1.76471118
163Increased mean platelet volume (HP:0011877)1.76227569
164Urticaria (HP:0001025)1.75057486
165Premature loss of primary teeth (HP:0006323)1.73636890
166Increased cerebral lipofuscin (HP:0011813)1.72693477
167Wide cranial sutures (HP:0010537)1.72667347
168Hypophosphatemia (HP:0002148)1.72120573
169Gastrointestinal stroma tumor (HP:0100723)1.71958685
170Mediastinal lymphadenopathy (HP:0100721)1.70066628
171Hemoptysis (HP:0002105)1.69175320
172Neoplasm of the tracheobronchial system (HP:0100552)1.69038671
173Abnormal hair laboratory examination (HP:0003328)1.67758244
174Dysostosis multiplex (HP:0000943)1.67587436
175Stomatitis (HP:0010280)1.67308560
176Pulmonary infiltrates (HP:0002113)1.67126442

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.63846768
2ERN13.78047847
3RIPK43.46614041
4INSRR3.40025720
5PRPF4B3.24530754
6TAOK33.02508212
7FGFR42.92511946
8MST1R2.68923131
9BCKDK2.62878434
10SIK12.59354732
11MAP3K22.33370146
12GRK62.31313879
13LMTK22.20193683
14PTK62.08877703
15RIPK11.95085519
16PKN21.90636244
17FLT31.88816756
18TRIB31.73423882
19MAP3K101.70264371
20TNK21.69081825
21PRKG21.59790575
22MAP2K21.47471565
23MAP3K131.42258847
24SMG11.38869682
25MAP3K71.38240880
26MST41.33588283
27MAP3K11.30227435
28TYK21.28971547
29KSR21.23076282
30BLK1.22036793
31MAP3K111.21207311
32PIK3CA1.20493808
33TAOK11.18984232
34FES1.18560094
35PTK21.18461580
36FGFR31.13878800
37JAK21.13666569
38JAK11.13556167
39MAP4K11.13523313
40IRAK41.13500548
41TBK11.13160233
42DAPK21.11166558
43PIK3CG1.08470382
44MET1.05594939
45TESK21.02585579
46CDK121.02413732
47MAPK111.01729339
48AKT31.00406963
49ITK1.00276157
50PRKAA20.99792294
51IKBKE0.98643556
52SIK30.96375533
53BTK0.95868235
54PDGFRA0.93850318
55ACVR1B0.92750227
56EPHB10.92603461
57MAPK120.90229443
58ICK0.89504321
59STK380.88510989
60PDPK10.88340496
61EPHA30.85774023
62JAK30.85591726
63MAPK150.84936126
64PDK10.84741687
65TESK10.84054151
66HCK0.83781708
67MAP2K40.83280126
68LATS10.82562776
69HIPK20.81821819
70RET0.81660940
71GRK50.79941913
72NUAK10.78724359
73PRKCH0.77779573
74LRRK20.77243097
75DYRK1B0.76536698
76NLK0.75578577
77MAPK70.75065485
78ZAP700.74896482
79SGK30.74720970
80CSK0.74493462
81PASK0.72938802
82MAP3K30.71728899
83ERBB20.71643016
84MAP2K60.69984641
85MAP3K90.68846855
86PRKAA10.68591893
87TGFBR20.68390107
88EPHA20.67718849
89EPHA40.65992476
90FGFR20.65521134
91RPS6KA20.65173542
92YES10.64930086
93MAP3K60.64034660
94NEK60.63758752
95IRAK20.63515826
96CAMKK10.61905736
97LCK0.59336432
98MAPKAPK30.58496244
99PRKCQ0.58420473
100BMPR20.58364283
101NTRK10.57506690
102PAK30.57179606
103SYK0.56710715
104SCYL20.56267771
105FYN0.56178635
106NME10.56000038
107MAP3K140.54864033
108ERBB40.53934125
109FER0.52272654
110MATK0.51610285
111MAP2K10.51424121
112CAMKK20.51323768
113EEF2K0.50982543
114SIK20.50482071
115IRAK10.50300313
116PRKACG0.49313490
117PAK40.48498541
118FGR0.47324518
119ARAF0.47148813
120PRKD30.46440545
121STK100.46074151
122CSF1R0.45770953
123TXK0.44708790
124LYN0.43491241
125PDGFRB0.42660591
126TAOK20.41390436
127CAMK1D0.40411753
128STK110.40097553
129CAMK2G0.38525483
130PRKCZ0.37751730
131TYRO30.37529221
132PRKCA0.35013908
133IRAK30.32878350
134MAP2K30.32424227
135PRKD20.32380995
136IGF1R0.32212233
137CDC42BPA0.31409092
138PRKCI0.30880771
139MARK20.30623267
140GSK3A0.30551896
141PRKD10.30508230
142KDR0.28538138

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.35253245
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.33749104
3Maturity onset diabetes of the young_Homo sapiens_hsa049503.13409583
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.12850007
5Sulfur metabolism_Homo sapiens_hsa009203.04188226
6Fat digestion and absorption_Homo sapiens_hsa049752.78016675
7Arginine biosynthesis_Homo sapiens_hsa002202.65257714
8Tryptophan metabolism_Homo sapiens_hsa003802.54301901
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.32796260
10Caffeine metabolism_Homo sapiens_hsa002322.14058293
11Fatty acid degradation_Homo sapiens_hsa000712.13234899
12Bile secretion_Homo sapiens_hsa049762.09123265
13Histidine metabolism_Homo sapiens_hsa003402.05200815
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.97165726
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.95855360
16Pentose and glucuronate interconversions_Homo sapiens_hsa000401.92949345
17Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.85445467
18Butanoate metabolism_Homo sapiens_hsa006501.83554871
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.77851837
20Starch and sucrose metabolism_Homo sapiens_hsa005001.75921652
21PPAR signaling pathway_Homo sapiens_hsa033201.71635360
22Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.69467606
23Complement and coagulation cascades_Homo sapiens_hsa046101.67687949
24Folate biosynthesis_Homo sapiens_hsa007901.56791607
25ABC transporters_Homo sapiens_hsa020101.55141839
26Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.54935171
27Vitamin digestion and absorption_Homo sapiens_hsa049771.52244486
28Peroxisome_Homo sapiens_hsa041461.46179649
29Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.43923089
30Drug metabolism - other enzymes_Homo sapiens_hsa009831.43030652
31Selenocompound metabolism_Homo sapiens_hsa004501.41113027
32Chemical carcinogenesis_Homo sapiens_hsa052041.39783232
33Other glycan degradation_Homo sapiens_hsa005111.36460627
34Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.35917649
35Steroid hormone biosynthesis_Homo sapiens_hsa001401.35285204
36beta-Alanine metabolism_Homo sapiens_hsa004101.34486151
37Propanoate metabolism_Homo sapiens_hsa006401.33114211
38Fatty acid metabolism_Homo sapiens_hsa012121.31853379
39Osteoclast differentiation_Homo sapiens_hsa043801.30209267
40Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.26113500
41Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.24960851
42Phenylalanine metabolism_Homo sapiens_hsa003601.24233494
43Leukocyte transendothelial migration_Homo sapiens_hsa046701.24115580
44Leishmaniasis_Homo sapiens_hsa051401.22825576
45Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.22813441
46Mineral absorption_Homo sapiens_hsa049781.21528736
47Carbohydrate digestion and absorption_Homo sapiens_hsa049731.20016285
48Acute myeloid leukemia_Homo sapiens_hsa052211.18336395
49Galactose metabolism_Homo sapiens_hsa000521.17362157
50B cell receptor signaling pathway_Homo sapiens_hsa046621.16435669
51Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.15842790
52Cyanoamino acid metabolism_Homo sapiens_hsa004601.10510534
53Retinol metabolism_Homo sapiens_hsa008301.10471001
54Graft-versus-host disease_Homo sapiens_hsa053321.09145535
55Renin-angiotensin system_Homo sapiens_hsa046141.08676862
56Pyruvate metabolism_Homo sapiens_hsa006201.07235614
57Allograft rejection_Homo sapiens_hsa053301.06512620
582-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.06189921
59Glycerolipid metabolism_Homo sapiens_hsa005611.04446605
60T cell receptor signaling pathway_Homo sapiens_hsa046601.02160311
61GnRH signaling pathway_Homo sapiens_hsa049121.01807529
62Autoimmune thyroid disease_Homo sapiens_hsa053201.00737132
63Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.99408269
64VEGF signaling pathway_Homo sapiens_hsa043700.97396249
65Staphylococcus aureus infection_Homo sapiens_hsa051500.96801703
66Arachidonic acid metabolism_Homo sapiens_hsa005900.94541555
67Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.91286736
68Tyrosine metabolism_Homo sapiens_hsa003500.89746931
69Choline metabolism in cancer_Homo sapiens_hsa052310.88631862
70Tuberculosis_Homo sapiens_hsa051520.87549791
71Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.87524918
72Fructose and mannose metabolism_Homo sapiens_hsa000510.86447080
73Arginine and proline metabolism_Homo sapiens_hsa003300.86353959
74Chemokine signaling pathway_Homo sapiens_hsa040620.85964698
75Renin secretion_Homo sapiens_hsa049240.83990338
76Long-term potentiation_Homo sapiens_hsa047200.83009013
77Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.82853630
78Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.82590244
79Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.81095149
80Carbon metabolism_Homo sapiens_hsa012000.79532493
81Non-small cell lung cancer_Homo sapiens_hsa052230.78303781
82Notch signaling pathway_Homo sapiens_hsa043300.77333536
83Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.77031670
84Toxoplasmosis_Homo sapiens_hsa051450.76272511
85Intestinal immune network for IgA production_Homo sapiens_hsa046720.74928225
86Pertussis_Homo sapiens_hsa051330.73657745
87Platelet activation_Homo sapiens_hsa046110.72237044
88Phospholipase D signaling pathway_Homo sapiens_hsa040720.72086351
89Biosynthesis of amino acids_Homo sapiens_hsa012300.71127111
90Lysine degradation_Homo sapiens_hsa003100.69691997
91TNF signaling pathway_Homo sapiens_hsa046680.69473755
92Renal cell carcinoma_Homo sapiens_hsa052110.68727214
93Toll-like receptor signaling pathway_Homo sapiens_hsa046200.68514265
94Endometrial cancer_Homo sapiens_hsa052130.68338527
95Inositol phosphate metabolism_Homo sapiens_hsa005620.66873087
96Type II diabetes mellitus_Homo sapiens_hsa049300.66708453
97AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.65555425
98Type I diabetes mellitus_Homo sapiens_hsa049400.65189592
99Cysteine and methionine metabolism_Homo sapiens_hsa002700.64670765
100Influenza A_Homo sapiens_hsa051640.64570496
101Endocytosis_Homo sapiens_hsa041440.64535251
102Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.63712275
103Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.62093627
104Insulin secretion_Homo sapiens_hsa049110.62032092
105Viral myocarditis_Homo sapiens_hsa054160.60723847
106Insulin resistance_Homo sapiens_hsa049310.60522891
107Chronic myeloid leukemia_Homo sapiens_hsa052200.60204940
108Estrogen signaling pathway_Homo sapiens_hsa049150.59615383
109Vascular smooth muscle contraction_Homo sapiens_hsa042700.59269133
110Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.58623699
111Protein digestion and absorption_Homo sapiens_hsa049740.56005301
112Hematopoietic cell lineage_Homo sapiens_hsa046400.55559596
113Pancreatic cancer_Homo sapiens_hsa052120.54324414
114Fatty acid elongation_Homo sapiens_hsa000620.53339123
115ErbB signaling pathway_Homo sapiens_hsa040120.53166347
116Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.52827499
117Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.52723075
118Neurotrophin signaling pathway_Homo sapiens_hsa047220.51933931
119NF-kappa B signaling pathway_Homo sapiens_hsa040640.51891500
120Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51100636
121Steroid biosynthesis_Homo sapiens_hsa001000.50628427
122Antigen processing and presentation_Homo sapiens_hsa046120.50476264
123Gastric acid secretion_Homo sapiens_hsa049710.49742366
124Primary immunodeficiency_Homo sapiens_hsa053400.49454114
125Pancreatic secretion_Homo sapiens_hsa049720.49159024
126Glutathione metabolism_Homo sapiens_hsa004800.47268321
127Thyroid hormone synthesis_Homo sapiens_hsa049180.46983641
128Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45361222
129Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.42445620
130Pentose phosphate pathway_Homo sapiens_hsa000300.39347491
131Glycerophospholipid metabolism_Homo sapiens_hsa005640.38925674
132Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.37429398
133Sulfur relay system_Homo sapiens_hsa041220.37015836
134Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.36704120
135alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.34605922
136Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.33940204
137Fatty acid biosynthesis_Homo sapiens_hsa000610.33250520
138Adipocytokine signaling pathway_Homo sapiens_hsa049200.31406014
139Metabolic pathways_Homo sapiens_hsa011000.28263024
140Glucagon signaling pathway_Homo sapiens_hsa049220.26328940
141Linoleic acid metabolism_Homo sapiens_hsa005910.22436956
142Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.20569411
143Prion diseases_Homo sapiens_hsa050200.19756157
144Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.17192883
145Aldosterone synthesis and secretion_Homo sapiens_hsa049250.14392651
146Hepatitis C_Homo sapiens_hsa051600.14019865
147Cocaine addiction_Homo sapiens_hsa050300.11351534
148AMPK signaling pathway_Homo sapiens_hsa041520.09342849
149Insulin signaling pathway_Homo sapiens_hsa049100.07005316
150African trypanosomiasis_Homo sapiens_hsa051430.04663568
151Prolactin signaling pathway_Homo sapiens_hsa049170.04637061
152Phosphatidylinositol signaling system_Homo sapiens_hsa040700.04339126
153Salivary secretion_Homo sapiens_hsa049700.04120567
154N-Glycan biosynthesis_Homo sapiens_hsa005100.00864497

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