VIPR2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a receptor for vasoactive intestinal peptide, a small neuropeptide. Vasoactive intestinal peptide is involved in smooth muscle relaxation, exocrine and endocrine secretion, and water and ion flux in lung and intestinal epithelia. Its actions are effected through integral membrane receptors associated with a guanine nucleotide binding protein which activates adenylate cyclase. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)8.94741094
2retinal rod cell development (GO:0046548)8.79120456
3negative regulation of cytosolic calcium ion concentration (GO:0051481)8.75181440
4relaxation of smooth muscle (GO:0044557)7.32155045
5retinal cone cell development (GO:0046549)6.50056687
6postsynaptic membrane organization (GO:0001941)6.16889327
7G-protein coupled glutamate receptor signaling pathway (GO:0007216)5.94815820
8sodium ion export (GO:0071436)5.88273957
9cellular potassium ion homeostasis (GO:0030007)5.70256997
10peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)5.69366791
11gamma-aminobutyric acid signaling pathway (GO:0007214)5.63926194
12eye photoreceptor cell development (GO:0042462)5.56742397
13photoreceptor cell development (GO:0042461)5.52855162
14behavioral response to nicotine (GO:0035095)5.43142112
15positive regulation of synapse maturation (GO:0090129)5.23651295
16synaptic vesicle exocytosis (GO:0016079)5.22536768
17potassium ion homeostasis (GO:0055075)5.20692179
18synaptic vesicle endocytosis (GO:0048488)4.66786106
19presynaptic membrane assembly (GO:0097105)4.56526199
20positive regulation of gastrulation (GO:2000543)4.45051352
21central nervous system myelination (GO:0022010)4.43805584
22axon ensheathment in central nervous system (GO:0032291)4.43805584
23eye photoreceptor cell differentiation (GO:0001754)4.41348452
24photoreceptor cell differentiation (GO:0046530)4.41348452
25cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.26843678
26protein localization to synapse (GO:0035418)4.20206623
27neuron cell-cell adhesion (GO:0007158)4.19398904
28energy homeostasis (GO:0097009)4.16826340
29innervation (GO:0060384)4.11212719
30regulation of synapse maturation (GO:0090128)4.09578916
31potassium ion export (GO:0071435)4.05415988
32response to host (GO:0075136)4.01649521
33response to host defenses (GO:0052200)4.01649521
34response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.01649521
35presynaptic membrane organization (GO:0097090)3.95807864
36calcium ion import (GO:0070509)3.85197085
37photoreceptor cell maintenance (GO:0045494)3.83515775
38nitric oxide mediated signal transduction (GO:0007263)3.82047777
39cellular sodium ion homeostasis (GO:0006883)3.74419398
40epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.73370363
41daunorubicin metabolic process (GO:0044597)3.71201146
42polyketide metabolic process (GO:0030638)3.71201146
43doxorubicin metabolic process (GO:0044598)3.71201146
44membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.71143038
45positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.70425634
46striatum development (GO:0021756)3.68466720
47regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.68368082
48dermatan sulfate biosynthetic process (GO:0030208)3.63573947
49response to host immune response (GO:0052572)3.61675010
50response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.61675010
51sialylation (GO:0097503)3.59131115
52exocrine pancreas development (GO:0031017)3.57963521
53neuroblast proliferation (GO:0007405)3.57462412
54regulation of voltage-gated calcium channel activity (GO:1901385)3.54974537
55regulation of synaptic vesicle exocytosis (GO:2000300)3.53871530
56atrial cardiac muscle cell action potential (GO:0086014)3.51447015
57mating behavior (GO:0007617)3.48894242
58positive regulation of oligodendrocyte differentiation (GO:0048714)3.46757392
59cell communication by electrical coupling (GO:0010644)3.45888518
60visual perception (GO:0007601)3.43396526
61sensory perception of light stimulus (GO:0050953)3.40818356
62tongue development (GO:0043586)3.35183935
63positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.34693475
64dentate gyrus development (GO:0021542)3.33786251
65synaptic vesicle transport (GO:0048489)3.32983078
66establishment of synaptic vesicle localization (GO:0097480)3.32983078
67phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.31904853
68purine nucleotide salvage (GO:0032261)3.29344393
69urinary tract smooth muscle contraction (GO:0014848)3.25650395
70pyrimidine nucleobase catabolic process (GO:0006208)3.23363675
71synaptic vesicle maturation (GO:0016188)3.21421907
72otic vesicle formation (GO:0030916)3.21309795
73dermatan sulfate metabolic process (GO:0030205)3.18863225
74membrane depolarization during action potential (GO:0086010)3.18115483
75astrocyte differentiation (GO:0048708)3.14650556
76membrane hyperpolarization (GO:0060081)3.13399078
77rhodopsin mediated signaling pathway (GO:0016056)3.13328147
78cGMP biosynthetic process (GO:0006182)3.10805128
79somite development (GO:0061053)3.10238499
80cGMP-mediated signaling (GO:0019934)3.09690448
81regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.08708637
82nephron tubule formation (GO:0072079)3.07884799
83protein-chromophore linkage (GO:0018298)3.07052395
84detection of visible light (GO:0009584)3.04960277
85detection of light stimulus (GO:0009583)3.03498439
86venous blood vessel morphogenesis (GO:0048845)3.01386519
87positive regulation of CREB transcription factor activity (GO:0032793)3.00810273
88axonemal dynein complex assembly (GO:0070286)2.99856136
89synaptic transmission, cholinergic (GO:0007271)2.99696309
90gamma-aminobutyric acid transport (GO:0015812)2.98750233
91retina development in camera-type eye (GO:0060041)2.96347652
92cytokine production involved in immune response (GO:0002367)2.95897463
93thalamus development (GO:0021794)2.94906137
94regulation of short-term neuronal synaptic plasticity (GO:0048172)2.94497890
95epithelial cilium movement (GO:0003351)2.94169286
96mechanosensory behavior (GO:0007638)2.89868826
97detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.89813688
98regulation of rhodopsin mediated signaling pathway (GO:0022400)2.89558976
99response to histamine (GO:0034776)2.88527952
100retinoic acid receptor signaling pathway (GO:0048384)2.86535699
101neuron fate determination (GO:0048664)2.85622403
102cAMP catabolic process (GO:0006198)2.84382533
103cilium movement (GO:0003341)2.82649129
104behavioral response to ethanol (GO:0048149)2.82555062
105potassium ion import (GO:0010107)2.82182182
106regulation of receptor internalization (GO:0002090)2.80860225
107substrate-independent telencephalic tangential migration (GO:0021826)2.79844744
108substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.79844744
109Sertoli cell development (GO:0060009)2.78689948
110regulation of action potential (GO:0098900)2.78245300
111cGMP metabolic process (GO:0046068)2.78156747
112positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.76831080
113mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.76831080
114neurotransmitter catabolic process (GO:0042135)2.76269307
115apical protein localization (GO:0045176)2.76037784
116negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.75822672
117nucleobase catabolic process (GO:0046113)2.75196499
118histone H3-K4 trimethylation (GO:0080182)2.73777339
119cilium or flagellum-dependent cell motility (GO:0001539)2.73776504
120retinal ganglion cell axon guidance (GO:0031290)2.73257373
121regulation of synapse structural plasticity (GO:0051823)2.73142377
122regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.73128841
123regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.73128841
124glucocorticoid biosynthetic process (GO:0006704)2.73083721
125prepulse inhibition (GO:0060134)2.73006311
126cerebellar Purkinje cell differentiation (GO:0021702)2.72537433
127purine-containing compound salvage (GO:0043101)2.71683478
128neuromuscular synaptic transmission (GO:0007274)2.71633862
129regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.71029250
130regulation of relaxation of muscle (GO:1901077)2.70996753
131regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.70902109
132enteric nervous system development (GO:0048484)2.70882639
133long-term synaptic potentiation (GO:0060291)2.70461484
134negative regulation of synaptic transmission, GABAergic (GO:0032229)2.70347200
135somite rostral/caudal axis specification (GO:0032525)2.70260192
136spinal cord motor neuron differentiation (GO:0021522)2.70180047
137regulation of synaptic vesicle transport (GO:1902803)2.69912061
138neuronal stem cell maintenance (GO:0097150)2.69337738
139appendage development (GO:0048736)2.68489450
140limb development (GO:0060173)2.68489450
141radial glial cell differentiation (GO:0060019)2.68271234
142peristalsis (GO:0030432)2.68145087
143nonmotile primary cilium assembly (GO:0035058)2.67582308
144positive regulation of TOR signaling (GO:0032008)2.67427630
145carbohydrate phosphorylation (GO:0046835)2.66653105
146locomotory exploration behavior (GO:0035641)2.66316381
147sulfation (GO:0051923)2.66216413
148startle response (GO:0001964)2.64955618
149auditory behavior (GO:0031223)2.64390594
150regulation of oligodendrocyte differentiation (GO:0048713)2.63071663
151axoneme assembly (GO:0035082)2.62917315
152viral genome replication (GO:0019079)2.62787429
153negative regulation of oligodendrocyte differentiation (GO:0048715)2.62692467
154cornea development in camera-type eye (GO:0061303)2.60975383
155regulation of neurotransmitter uptake (GO:0051580)2.60821768
156regulation of respiratory system process (GO:0044065)2.59888268
157neuronal action potential (GO:0019228)2.58431063
158telencephalon development (GO:0021537)2.58281103
159cell proliferation in forebrain (GO:0021846)2.57438470
160fucose catabolic process (GO:0019317)2.56903819
161L-fucose metabolic process (GO:0042354)2.56903819
162L-fucose catabolic process (GO:0042355)2.56903819
163positive regulation of action potential (GO:0045760)2.55985450
164regulation of actin filament-based movement (GO:1903115)2.55180236
165cyclic nucleotide catabolic process (GO:0009214)2.55050789
166epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.52292897
167regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.51908350
168response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.50663191
169calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.49439291
170negative regulation of transcription regulatory region DNA binding (GO:2000678)2.48351460
171regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.47220084
172negative regulation of astrocyte differentiation (GO:0048712)2.46127291
173neuronal action potential propagation (GO:0019227)2.44250589
174negative regulation of reactive oxygen species metabolic process (GO:2000378)2.44143819
175auditory receptor cell stereocilium organization (GO:0060088)2.44106797
176transmission of nerve impulse (GO:0019226)2.42988117
177exploration behavior (GO:0035640)2.38425233
178inner ear receptor stereocilium organization (GO:0060122)2.38099570
179kidney morphogenesis (GO:0060993)2.37455574
180dendritic spine morphogenesis (GO:0060997)2.36944019
181neurotransmitter uptake (GO:0001504)2.36743342
182mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.35601647
183vocalization behavior (GO:0071625)2.35145956
184ionotropic glutamate receptor signaling pathway (GO:0035235)2.34554986
185actin-myosin filament sliding (GO:0033275)2.34474932
186muscle filament sliding (GO:0030049)2.34474932
187synapse assembly (GO:0007416)2.34063289
188nephron tubule morphogenesis (GO:0072078)2.33395898
189detection of light stimulus involved in visual perception (GO:0050908)11.8652625
190detection of light stimulus involved in sensory perception (GO:0050962)11.8652625

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.97160708
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse4.72265695
3GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.64105713
4GBX2_23144817_ChIP-Seq_PC3_Human3.51967597
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.26690328
6SMAD_19615063_ChIP-ChIP_OVARY_Human3.18110493
7IKZF1_21737484_ChIP-ChIP_HCT116_Human2.84447229
8IGF1R_20145208_ChIP-Seq_DFB_Human2.78670323
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.72274661
10ZNF274_21170338_ChIP-Seq_K562_Hela2.66314898
11P53_22127205_ChIP-Seq_FIBROBLAST_Human2.65321764
12EZH2_27294783_Chip-Seq_ESCs_Mouse2.47668529
13* REST_21632747_ChIP-Seq_MESCs_Mouse2.31500263
14SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.25877637
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.24598355
16VDR_22108803_ChIP-Seq_LS180_Human2.21268744
17SUZ12_27294783_Chip-Seq_ESCs_Mouse2.21181027
18* DROSHA_22980978_ChIP-Seq_HELA_Human2.20483600
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.10554482
20* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.10314849
21JARID2_20064375_ChIP-Seq_MESCs_Mouse2.09486895
22FUS_26573619_Chip-Seq_HEK293_Human2.06323805
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.05501164
24SCL_19346495_ChIP-Seq_HPC-7_Human2.04739665
25PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.04463373
26* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.04305297
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.99427272
28EZH2_27304074_Chip-Seq_ESCs_Mouse1.97570971
29RNF2_27304074_Chip-Seq_ESCs_Mouse1.95947716
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.94963052
31* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.93491345
32FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.91822211
33CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.91511800
34FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.91497020
35* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.87976737
36REST_18959480_ChIP-ChIP_MESCs_Mouse1.86803374
37ZFP57_27257070_Chip-Seq_ESCs_Mouse1.86374838
38AR_21572438_ChIP-Seq_LNCaP_Human1.84873736
39VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.79195122
40BMI1_23680149_ChIP-Seq_NPCS_Mouse1.73896490
41TAF15_26573619_Chip-Seq_HEK293_Human1.73528931
42DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.70903018
43* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.69991698
44EED_16625203_ChIP-ChIP_MESCs_Mouse1.68067869
45RUNX_20019798_ChIP-Seq_JUKART_Human1.68012870
46SMAD4_21799915_ChIP-Seq_A2780_Human1.65327778
47CTBP2_25329375_ChIP-Seq_LNCAP_Human1.61946242
48EZH2_18974828_ChIP-Seq_MESCs_Mouse1.57015262
49RNF2_18974828_ChIP-Seq_MESCs_Mouse1.57015262
50RNF2_27304074_Chip-Seq_NSC_Mouse1.56765329
51PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.52429709
52SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.45619020
53HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.44625225
54POU3F2_20337985_ChIP-ChIP_501MEL_Human1.43962299
55LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.42326119
56RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.41846841
57MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.40251397
58SMAD3_21741376_ChIP-Seq_EPCs_Human1.39097054
59CTBP1_25329375_ChIP-Seq_LNCAP_Human1.37803268
60IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.37302536
61CBP_20019798_ChIP-Seq_JUKART_Human1.37302536
62AR_25329375_ChIP-Seq_VCAP_Human1.34698834
63TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.32870493
64PIAS1_25552417_ChIP-Seq_VCAP_Human1.31868615
65TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.31562249
66NOTCH1_21737748_ChIP-Seq_TLL_Human1.29276602
67P300_19829295_ChIP-Seq_ESCs_Human1.28479006
68ELK4_26923725_Chip-Seq_MESODERM_Mouse1.27391416
69STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.26775347
70MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.25340703
71ER_23166858_ChIP-Seq_MCF-7_Human1.24541953
72POU5F1_16153702_ChIP-ChIP_HESCs_Human1.24318079
73MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.23148361
74BP1_19119308_ChIP-ChIP_Hs578T_Human1.23033887
75* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.21907832
76RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.19908048
77MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.19397812
78RARB_27405468_Chip-Seq_BRAIN_Mouse1.18826321
79SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.18287586
80RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.17733421
81ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.16159569
82EWS_26573619_Chip-Seq_HEK293_Human1.15768114
83CBX2_27304074_Chip-Seq_ESCs_Mouse1.15419601
84MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.14288734
85BCAT_22108803_ChIP-Seq_LS180_Human1.12908603
86RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.12054017
87CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.11565492
88PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.11246095
89DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.10734976
90* RING1B_27294783_Chip-Seq_ESCs_Mouse1.10213814
91ERG_21242973_ChIP-ChIP_JURKAT_Human1.10093867
92CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09991370
93* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.09290953
94* AR_19668381_ChIP-Seq_PC3_Human1.08598131
95UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08409167
96* STAT3_23295773_ChIP-Seq_U87_Human1.08191153
97POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07409416
98TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07409416
99* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.07379055
100* TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.05737168
101CTCF_27219007_Chip-Seq_Bcells_Human1.05512880
102TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05032316
103LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.04608588
104* FLI1_21867929_ChIP-Seq_TH2_Mouse1.04365921
105TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03959070
106RUNX2_22187159_ChIP-Seq_PCA_Human1.03762637
107SMAD3_21741376_ChIP-Seq_HESCs_Human1.00961379
108* SOX2_21211035_ChIP-Seq_LN229_Gbm1.00169639
109TCF4_23295773_ChIP-Seq_U87_Human0.98724223
110TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.98499634
111PRDM14_20953172_ChIP-Seq_ESCs_Human0.97886145
112* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97019782
113RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.96575412
114SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96483986
115TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95739224
116FLI1_27457419_Chip-Seq_LIVER_Mouse0.95098969
117* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.95049729
118ERA_21632823_ChIP-Seq_H3396_Human0.94960727
119GATA1_19941827_ChIP-Seq_MEL_Mouse0.94579349
120LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94100480
121SRF_21415370_ChIP-Seq_HL-1_Mouse0.94039579
122NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93608757
123MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.93458930
124SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.92983700
125HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.92570280
126PCGF2_27294783_Chip-Seq_NPCs_Mouse0.91305267
127WDR5_24793694_ChIP-Seq_LNCAP_Human0.91190798
128SMAD3_21741376_ChIP-Seq_ESCs_Human0.91027652
129TP53_20018659_ChIP-ChIP_R1E_Mouse0.91008905
130GATA1_26923725_Chip-Seq_HPCs_Mouse0.90577680
131AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.90085215
132GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89864771
133TP53_22573176_ChIP-Seq_HFKS_Human0.89108783
134RING1B_27294783_Chip-Seq_NPCs_Mouse0.88575290
135OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.87133956
136KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.86609977
137PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.86462365
138EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.85275413

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005551_abnormal_eye_electrophysiolog6.88112047
2MP0006292_abnormal_olfactory_placode5.17670738
3MP0006072_abnormal_retinal_apoptosis4.81606937
4MP0002090_abnormal_vision4.31539174
5MP0004782_abnormal_surfactant_physiolog4.12481977
6MP0003136_yellow_coat_color3.75121286
7MP0001984_abnormal_olfaction3.67388253
8MP0005253_abnormal_eye_physiology3.61139563
9MP0003950_abnormal_plasma_membrane3.18339759
10* MP0001502_abnormal_circadian_rhythm2.98669507
11MP0004233_abnormal_muscle_weight2.97881522
12MP0002837_dystrophic_cardiac_calcinosis2.83043020
13MP0005195_abnormal_posterior_eye2.78268013
14MP0002638_abnormal_pupillary_reflex2.30495742
15MP0001188_hyperpigmentation2.22874192
16MP0003646_muscle_fatigue2.04508166
17MP0008789_abnormal_olfactory_epithelium2.01162944
18MP0010030_abnormal_orbit_morphology1.95539180
19MP0001485_abnormal_pinna_reflex1.95410107
20MP0005499_abnormal_olfactory_system1.94112967
21MP0005394_taste/olfaction_phenotype1.94112967
22MP0009379_abnormal_foot_pigmentation1.93664060
23MP0000631_abnormal_neuroendocrine_gland1.91055972
24MP0004130_abnormal_muscle_cell1.90677139
25MP0002234_abnormal_pharynx_morphology1.87652647
26MP0008775_abnormal_heart_ventricle1.87481849
27MP0001324_abnormal_eye_pigmentation1.86817227
28MP0000778_abnormal_nervous_system1.80919518
29MP0002735_abnormal_chemical_nociception1.76247312
30MP0005220_abnormal_exocrine_pancreas1.71253318
31MP0010368_abnormal_lymphatic_system1.63126638
32MP0005595_abnormal_vascular_smooth1.61415992
33MP0005248_abnormal_Harderian_gland1.60245495
34MP0001873_stomach_inflammation1.57527380
35MP0005391_vision/eye_phenotype1.57164965
36MP0005670_abnormal_white_adipose1.57129430
37MP0006276_abnormal_autonomic_nervous1.54596035
38MP0003011_delayed_dark_adaptation1.53274052
39MP0005167_abnormal_blood-brain_barrier1.51574586
40MP0004215_abnormal_myocardial_fiber1.50731381
41MP0000566_synostosis1.48945438
42MP0001486_abnormal_startle_reflex1.47926735
43MP0004133_heterotaxia1.47236259
44MP0002733_abnormal_thermal_nociception1.45669037
45MP0001529_abnormal_vocalization1.45296730
46MP0002734_abnormal_mechanical_nocicepti1.45193124
47MP0003787_abnormal_imprinting1.44031696
48MP0001346_abnormal_lacrimal_gland1.42810910
49MP0002752_abnormal_somatic_nervous1.42541575
50MP0004859_abnormal_synaptic_plasticity1.42444025
51MP0009697_abnormal_copulation1.40384877
52MP0002229_neurodegeneration1.39890842
53MP0001970_abnormal_pain_threshold1.38903661
54MP0000026_abnormal_inner_ear1.36737176
55MP0001986_abnormal_taste_sensitivity1.35001522
56MP0008877_abnormal_DNA_methylation1.32844318
57MP0000049_abnormal_middle_ear1.29921747
58MP0010386_abnormal_urinary_bladder1.27858944
59MP0004145_abnormal_muscle_electrophysio1.24862494
60MP0002184_abnormal_innervation1.24841702
61MP0002876_abnormal_thyroid_physiology1.23693241
62MP0002089_abnormal_postnatal_growth/wei1.22316468
63MP0000465_gastrointestinal_hemorrhage1.22092590
64MP0005171_absent_coat_pigmentation1.21792805
65MP0002272_abnormal_nervous_system1.18102525
66MP0004742_abnormal_vestibular_system1.18034523
67MP0001905_abnormal_dopamine_level1.16587064
68MP0005174_abnormal_tail_pigmentation1.10930957
69MP0002064_seizures1.10620831
70MP0008004_abnormal_stomach_pH1.09986692
71MP0003938_abnormal_ear_development1.08953775
72MP0005075_abnormal_melanosome_morpholog1.06035876
73MP0003635_abnormal_synaptic_transmissio1.05826907
74MP0003122_maternal_imprinting1.05060649
75MP0002102_abnormal_ear_morphology1.05015332
76MP0003137_abnormal_impulse_conducting1.03940220
77MP0002067_abnormal_sensory_capabilities1.02839003
78MP0003879_abnormal_hair_cell1.02302933
79MP0009046_muscle_twitch1.02025819
80MP0004142_abnormal_muscle_tone1.01990161
81MP0008569_lethality_at_weaning1.00527291
82MP0001270_distended_abdomen0.99892623
83MP0000579_abnormal_nail_morphology0.99858666
84MP0008872_abnormal_physiological_respon0.97441161
85MP0002882_abnormal_neuron_morphology0.94791413
86MP0002249_abnormal_larynx_morphology0.94753309
87MP0004924_abnormal_behavior0.94693852
88MP0005386_behavior/neurological_phenoty0.94693852
89MP0002332_abnormal_exercise_endurance0.93176273
90MP0004147_increased_porphyrin_level0.93104468
91MP0009780_abnormal_chondrocyte_physiolo0.92551754
92MP0000749_muscle_degeneration0.91960495
93MP0001293_anophthalmia0.91583986
94MP0004270_analgesia0.91060392
95MP0004036_abnormal_muscle_relaxation0.90829707
96MP0005620_abnormal_muscle_contractility0.90565956
97MP0004084_abnormal_cardiac_muscle0.89899059
98MP0003943_abnormal_hepatobiliary_system0.89240902
99MP0001968_abnormal_touch/_nociception0.88937213
100MP0003937_abnormal_limbs/digits/tail_de0.88929760
101MP0002277_abnormal_respiratory_mucosa0.87759534
102MP0002751_abnormal_autonomic_nervous0.87357630
103MP0002152_abnormal_brain_morphology0.85449580
104MP0004885_abnormal_endolymph0.84002417
105MP0003880_abnormal_central_pattern0.83892373
106MP0002736_abnormal_nociception_after0.83281834
107MP0001440_abnormal_grooming_behavior0.81745468
108MP0005646_abnormal_pituitary_gland0.81712035
109MP0003283_abnormal_digestive_organ0.81265121
110MP0002063_abnormal_learning/memory/cond0.80609324
111MP0001664_abnormal_digestion0.79315779
112MP0009745_abnormal_behavioral_response0.76761153
113MP0002653_abnormal_ependyma_morphology0.75905916
114* MP0002066_abnormal_motor_capabilities/c0.75823314
115MP0003878_abnormal_ear_physiology0.75135712
116MP0005377_hearing/vestibular/ear_phenot0.75135712
117MP0000751_myopathy0.75085674
118MP0003119_abnormal_digestive_system0.74720867
119MP0003868_abnormal_feces_composition0.70741175
120MP0004264_abnormal_extraembryonic_tissu0.70390858
121MP0001879_abnormal_lymphatic_vessel0.69853096
122MP0002557_abnormal_social/conspecific_i0.68707457
123MP0002396_abnormal_hematopoietic_system0.68069018
124MP0004134_abnormal_chest_morphology0.67474666
125MP0000230_abnormal_systemic_arterial0.67018353
126MP0001661_extended_life_span0.66793070
127MP0003763_abnormal_thymus_physiology0.66349189
128MP0002938_white_spotting0.65413261
129MP0005423_abnormal_somatic_nervous0.65373298
130MP0001666_abnormal_nutrient_absorption0.63037443
131MP0005464_abnormal_platelet_physiology0.61454354
132MP0002108_abnormal_muscle_morphology0.60577863
133MP0008260_abnormal_autophagy0.60558837
134MP0002572_abnormal_emotion/affect_behav0.59619412
135MP0001501_abnormal_sleep_pattern0.59397435
136MP0001663_abnormal_digestive_system0.56361045
137MP0003634_abnormal_glial_cell0.53346406
138MP0005365_abnormal_bile_salt0.52617729
139MP0002127_abnormal_cardiovascular_syste0.52423108
140MP0008007_abnormal_cellular_replicative0.50560579
141MP0002909_abnormal_adrenal_gland0.48657032
142MP0004085_abnormal_heartbeat0.48533061
143MP0003115_abnormal_respiratory_system0.47659246
144MP0001963_abnormal_hearing_physiology0.45108802
145MP0005409_darkened_coat_color0.43793647
146MP0004043_abnormal_pH_regulation0.43603484
147MP0004811_abnormal_neuron_physiology0.41712539
148MP0000955_abnormal_spinal_cord0.39898152

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)9.56280222
2Central scotoma (HP:0000603)8.60777035
3Abnormality of macular pigmentation (HP:0008002)7.59756491
4Abnormal rod and cone electroretinograms (HP:0008323)7.16675506
5Septo-optic dysplasia (HP:0100842)6.69136849
6Scotoma (HP:0000575)5.46717403
7Albinism (HP:0001022)5.26453953
8Hypoplasia of the fovea (HP:0007750)4.85856130
9Aplasia/Hypoplasia of the fovea (HP:0008060)4.85856130
10Keratoconus (HP:0000563)4.81444501
11Increased corneal curvature (HP:0100692)4.81444501
12Decreased central vision (HP:0007663)4.73872687
13Febrile seizures (HP:0002373)4.19519497
14Abnormality of the fovea (HP:0000493)4.08792695
15Bony spicule pigmentary retinopathy (HP:0007737)4.03093222
16Epileptic encephalopathy (HP:0200134)3.91776101
17Pendular nystagmus (HP:0012043)3.75319298
18Oligodactyly (hands) (HP:0001180)3.71369375
19Absent rod-and cone-mediated responses on ERG (HP:0007688)3.65254125
20Absent septum pellucidum (HP:0001331)3.57003094
21Optic nerve hypoplasia (HP:0000609)3.50738333
22Abnormality of midbrain morphology (HP:0002418)3.39249849
23Molar tooth sign on MRI (HP:0002419)3.39249849
24Pancreatic fibrosis (HP:0100732)3.38264675
25Rib fusion (HP:0000902)3.29621225
26Abolished electroretinogram (ERG) (HP:0000550)3.17517714
27Pancreatic cysts (HP:0001737)3.15834727
28Nephronophthisis (HP:0000090)3.15516542
29Aplasia/Hypoplasia of the macula (HP:0008059)3.09351606
30Abnormality of the septum pellucidum (HP:0007375)2.97841758
31Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.97089756
32Cone-rod dystrophy (HP:0000548)2.89692861
33Aplasia/Hypoplasia affecting the retina (HP:0008061)2.84778394
34Chronic hepatic failure (HP:0100626)2.84332438
35Posterior subcapsular cataract (HP:0007787)2.84274393
36Attenuation of retinal blood vessels (HP:0007843)2.81935489
37Abnormality of the sella turcica (HP:0002679)2.81466062
38Cerebellar dysplasia (HP:0007033)2.77262242
39Absent/shortened dynein arms (HP:0200106)2.77173809
40Dynein arm defect of respiratory motile cilia (HP:0012255)2.77173809
41Growth hormone deficiency (HP:0000824)2.75505938
42Polydipsia (HP:0001959)2.74771157
43Abnormal drinking behavior (HP:0030082)2.74771157
44Visual hallucinations (HP:0002367)2.72292772
45Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.67356210
46Oligodactyly (HP:0012165)2.66435784
47Abnormal respiratory epithelium morphology (HP:0012253)2.66214743
48Abnormal respiratory motile cilium morphology (HP:0005938)2.66214743
49Generalized hypopigmentation (HP:0007513)2.66132908
50Abnormal ciliary motility (HP:0012262)2.63959690
51Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.59365999
52Anophthalmia (HP:0000528)2.59288035
53Focal motor seizures (HP:0011153)2.58769409
54Abnormality of alanine metabolism (HP:0010916)2.57050756
55Hyperalaninemia (HP:0003348)2.57050756
56Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.57050756
57Absence seizures (HP:0002121)2.53880640
58Abnormality of the renal medulla (HP:0100957)2.50274256
59Abnormality of the 4th metacarpal (HP:0010012)2.48163391
60Severe Myopia (HP:0011003)2.47502777
61Abdominal situs inversus (HP:0003363)2.46083988
62Abnormality of abdominal situs (HP:0011620)2.46083988
63Birth length less than 3rd percentile (HP:0003561)2.42175941
64Photophobia (HP:0000613)2.42143569
65Chorioretinal atrophy (HP:0000533)2.39782790
66Mesangial abnormality (HP:0001966)2.36860444
67Anencephaly (HP:0002323)2.33596623
68Abnormal respiratory motile cilium physiology (HP:0012261)2.32172397
69Cystic liver disease (HP:0006706)2.31045858
70Cholecystitis (HP:0001082)2.30572232
71Abnormal gallbladder physiology (HP:0012438)2.30572232
72Abnormal pupillary function (HP:0007686)2.30053331
73Genetic anticipation (HP:0003743)2.24745056
74Sclerocornea (HP:0000647)2.18321606
75Abnormality of the diencephalon (HP:0010662)2.13267818
76Fibular hypoplasia (HP:0003038)2.11620276
77Anterior segment dysgenesis (HP:0007700)2.11359162
78Hemiparesis (HP:0001269)2.10595464
79Large for gestational age (HP:0001520)2.07659108
80Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.07514528
81Myokymia (HP:0002411)2.05576887
82Myotonia (HP:0002486)2.04600313
83Polyuria (HP:0000103)2.03353741
84Hyperventilation (HP:0002883)2.01335405
85Congenital primary aphakia (HP:0007707)2.00845597
86Postaxial foot polydactyly (HP:0001830)2.00686054
87Prolonged QT interval (HP:0001657)2.00334892
88Congenital stationary night blindness (HP:0007642)14.1279145
89Gait imbalance (HP:0002141)1.99749559
90Tubular atrophy (HP:0000092)1.98625487
91Nephrogenic diabetes insipidus (HP:0009806)1.98069037
92Renal cortical cysts (HP:0000803)1.96549082
93Constricted visual fields (HP:0001133)1.94530984
94Medial flaring of the eyebrow (HP:0010747)1.93467176
95Lipid accumulation in hepatocytes (HP:0006561)1.93263882
96Neoplasm of the heart (HP:0100544)1.93229293
97Diastasis recti (HP:0001540)1.92778204
98Type II diabetes mellitus (HP:0005978)1.92621807
99Increased neuronal autofluorescent lipopigment (HP:0002074)1.92404830
100Focal seizures (HP:0007359)1.91511182
101Progressive cerebellar ataxia (HP:0002073)1.90965441
102Type II lissencephaly (HP:0007260)1.90256220
103Abnormality of the labia minora (HP:0012880)1.90085014
104Limb dystonia (HP:0002451)1.89534737
105Bundle branch block (HP:0011710)1.89028588
106Abnormal hair whorl (HP:0010721)1.87411257
107Calf muscle hypertrophy (HP:0008981)1.86211026
108Flat cornea (HP:0007720)1.85762904
109Occipital encephalocele (HP:0002085)1.85338345
110Morphological abnormality of the inner ear (HP:0011390)1.84323625
111Congenital hepatic fibrosis (HP:0002612)1.83443308
112Concave nail (HP:0001598)1.82737088
113Rhinitis (HP:0012384)1.82648190
114Mutism (HP:0002300)1.82192936
115Lissencephaly (HP:0001339)1.80918439
116Progressive macrocephaly (HP:0004481)1.80160946
117Primary adrenal insufficiency (HP:0008207)1.78821055
118Optic disc pallor (HP:0000543)1.78732126
119Abnormality of the fingertips (HP:0001211)1.78682433
120Muscle hypertrophy of the lower extremities (HP:0008968)1.78289963
121Sudden death (HP:0001699)1.77913859
122Dialeptic seizures (HP:0011146)1.77372197
123Supernumerary spleens (HP:0009799)1.77120218
124Patellar aplasia (HP:0006443)1.75889318
125Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.75622365
126Increased circulating renin level (HP:0000848)1.75277199
127Hyperglycinuria (HP:0003108)1.75180254
128Mitochondrial inheritance (HP:0001427)1.74799371
129Left ventricular hypertrophy (HP:0001712)1.73972347
130Hypoplasia of the ulna (HP:0003022)1.73845367
131Poor coordination (HP:0002370)1.73279278
132Abnormal urine output (HP:0012590)1.73037197
133Aplasia/Hypoplasia of the tongue (HP:0010295)1.72897247
134Pachygyria (HP:0001302)1.70865236
135Chorioretinal coloboma (HP:0000567)1.70528387
136Abnormality of cochlea (HP:0000375)1.70420932
137Adactyly (HP:0009776)1.70025540
138Holoprosencephaly (HP:0001360)1.69693531
139Aplasia/Hypoplasia of the spleen (HP:0010451)1.69655912
140Primary atrial arrhythmia (HP:0001692)1.69251158
141Aplasia/Hypoplasia of the fibula (HP:0006492)1.68938550
142Asplenia (HP:0001746)1.68762626
143Acute necrotizing encephalopathy (HP:0006965)1.68649897
144Metabolic alkalosis (HP:0200114)1.68356853
145Astigmatism (HP:0000483)1.67285421
146Retinitis pigmentosa (HP:0000510)1.63772556
147Retinal dysplasia (HP:0007973)1.62471611
148Subcapsular cataract (HP:0000523)1.60137437
149Depression (HP:0000716)1.59767400
150Spondylolisthesis (HP:0003302)1.57596201
151Maternal diabetes (HP:0009800)1.57152387
152Abnormality of DNA repair (HP:0003254)1.55138543
153Volvulus (HP:0002580)1.54760722
154Unsteady gait (HP:0002317)1.54574360
155True hermaphroditism (HP:0010459)1.52936211
156Submucous cleft hard palate (HP:0000176)1.51373900
157Type 2 muscle fiber atrophy (HP:0003554)1.48303741
158Increased cerebral lipofuscin (HP:0011813)1.48294625
159Obsessive-compulsive behavior (HP:0000722)1.47565944
160Pigmentary retinal degeneration (HP:0001146)1.46877513
161Neoplasm of the oral cavity (HP:0100649)1.46774058
162Aplasia/Hypoplasia of the lens (HP:0008063)1.46532584
163Aplastic anemia (HP:0001915)1.45263753
164Narrow nasal bridge (HP:0000446)1.44752386
165Congenital sensorineural hearing impairment (HP:0008527)1.44305238
166Open mouth (HP:0000194)1.40067744
167Broad metatarsal (HP:0001783)1.31593562
168Spinal canal stenosis (HP:0003416)1.31072732
169Abnormality of the renal cortex (HP:0011035)1.30702244
170Cutis marmorata (HP:0000965)1.29937143
171Abnormal delayed hypersensitivity skin test (HP:0002963)1.29646398
172Exercise-induced myalgia (HP:0003738)1.28914618
173Scrotal hypoplasia (HP:0000046)1.26696879
174Generalized aminoaciduria (HP:0002909)1.26031635
175Keratitis (HP:0000491)1.23232923
176Atrial fibrillation (HP:0005110)1.22779314
177Truncal obesity (HP:0001956)1.21561947

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PAK63.53258281
2MARK13.35233494
3CDK83.26076726
4NEK13.25856250
5PRPF4B3.23723735
6TAOK23.07959602
7MAP3K63.03437471
8EPHA32.78977670
9MAP2K32.61502557
10WNK42.56330937
11ZAK2.43834459
12TLK12.41935153
13NTRK22.39001240
14OBSCN2.36768424
15TNIK2.25770310
16TNK22.24548334
17MAPK152.22669747
18MAP3K72.10555853
19RIPK12.08928200
20KIT2.00199328
21TXK1.91263918
22WNK31.89004784
23TAOK31.81319118
24INSRR1.80559434
25TIE11.80483475
26DYRK21.80216293
27NLK1.77138323
28AKT31.76767526
29DYRK1A1.71150775
30TEC1.66473919
31PRKD21.66441103
32SIK31.65074815
33NTRK31.63120517
34FLT31.62856957
35TYRO31.60417216
36EPHA41.52884488
37MAP3K41.51839588
38RPS6KB21.49528421
39PHKG11.45006941
40PHKG21.45006941
41PNCK1.43487377
42CDK31.42272024
43PASK1.41166246
44PIK3CA1.40398207
45MAP4K21.39633549
46MINK11.39156647
47MAP2K61.38254321
48FGFR21.37681148
49TSSK61.33758577
50ZAP701.30560017
51CAMK11.30406392
52STK391.28453791
53FRK1.28245982
54MAP3K131.25730479
55ACVR1B1.24185874
56MUSK1.18497521
57STK161.18286082
58CLK11.18231942
59CSNK1G21.17459072
60CSNK1G11.16596891
61TGFBR11.15427422
62PKN11.11623157
63FES1.10337740
64PAK31.09821408
65CSNK1G31.08550231
66BTK1.07255775
67NUAK11.04623408
68NME11.04435025
69MAP2K41.01510270
70BCKDK0.99694588
71PINK10.98025055
72CSNK1A1L0.94004185
73PRKCG0.93458027
74MAP2K70.91374420
75CAMK2A0.90789742
76SGK20.86011655
77MAPKAPK50.85643255
78ADRBK20.85639496
79UHMK10.85608685
80DAPK20.85063534
81BMPR1B0.84012517
82GRK10.83409512
83CAMK40.83002676
84SGK4940.81404774
85SGK2230.81404774
86STK38L0.81122530
87OXSR10.79851829
88CAMKK20.79469297
89ERBB30.77232449
90MAP2K20.74259511
91EPHB20.69891620
92CAMK2B0.67713989
93MAP4K10.67460543
94STK380.64617061
95CAMK2D0.64574014
96VRK10.63837479
97YES10.62822082
98MAP3K90.62592297
99STK110.61289338
100PRKG20.61270509
101MAPKAPK30.61053119
102MAPK120.60818940
103MKNK20.60756751
104MAP2K10.60448496
105PKN20.60420412
106CDK90.58982727
107CAMK2G0.58676734
108EEF2K0.58411904
109CAMK1D0.58212986
110CAMKK10.57103855
111BRD40.57031475
112ROCK10.56939761
113PRKCQ0.56593188
114MATK0.56367822
115SGK30.56365297
116ATR0.55793847
117PRKCH0.52311805
118HIPK20.52178952
119ERBB20.51256315
120PLK30.50214713
121PRKAA10.48919569
122PRKG10.48889610
123SGK10.48426701
124CSNK1D0.47069726
125NEK20.46752647
126PRKCZ0.46118073
127CDK50.45993459
128CASK0.45743375
129CCNB10.44742888
130MARK20.44671803
131CSNK1A10.44248195
132RPS6KA60.43616505
133RPS6KB10.43313873
134CHUK0.41863695
135JAK30.41672251
136PRKCE0.41148185
137MAPK10.41085873
138MAPK90.40345357
139RPS6KA40.39818485
140MAPK100.39596614
141MYLK0.39117926
142PRKD30.37546618
143PDK20.37494814
144RPS6KA50.36909694
145RAF10.36514903
146PRKCA0.36434327
147AKT10.36364796
148ADRBK10.36331095
149HCK0.33654951
150KSR10.33148446
151GSK3B0.30746078
152PAK20.30397200
153PRKACA0.29990865
154TGFBR20.29882871
155MAPK130.29301599
156RET0.29156383
157LCK0.27928632

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.83698067
2GABAergic synapse_Homo sapiens_hsa047273.74012136
3Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006043.29007222
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047233.26452385
5Morphine addiction_Homo sapiens_hsa050323.24895020
6Synaptic vesicle cycle_Homo sapiens_hsa047213.24473175
7Circadian rhythm_Homo sapiens_hsa047103.16955430
8Phototransduction_Homo sapiens_hsa047442.66094420
9Nitrogen metabolism_Homo sapiens_hsa009102.55808422
10Oxidative phosphorylation_Homo sapiens_hsa001902.46639135
11Fructose and mannose metabolism_Homo sapiens_hsa000512.45986794
12Circadian entrainment_Homo sapiens_hsa047132.38876669
13alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.25574055
14Parkinsons disease_Homo sapiens_hsa050122.19050060
15Linoleic acid metabolism_Homo sapiens_hsa005912.07517256
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.04142589
17Sulfur relay system_Homo sapiens_hsa041221.97318349
18Renin secretion_Homo sapiens_hsa049241.95545570
19Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.92948125
20Insulin secretion_Homo sapiens_hsa049111.84101780
21Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.80303469
22Basal cell carcinoma_Homo sapiens_hsa052171.67689427
23Butanoate metabolism_Homo sapiens_hsa006501.64365437
24Galactose metabolism_Homo sapiens_hsa000521.61536803
25Olfactory transduction_Homo sapiens_hsa047401.61508291
26Alzheimers disease_Homo sapiens_hsa050101.58554411
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.55814204
28Cholinergic synapse_Homo sapiens_hsa047251.55044980
29Salivary secretion_Homo sapiens_hsa049701.52903309
30Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.48752946
31Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.46781086
32Oxytocin signaling pathway_Homo sapiens_hsa049211.45181620
33Pentose phosphate pathway_Homo sapiens_hsa000301.45149770
34Huntingtons disease_Homo sapiens_hsa050161.43271814
35Central carbon metabolism in cancer_Homo sapiens_hsa052301.42954885
36Hedgehog signaling pathway_Homo sapiens_hsa043401.41424241
37Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.40760998
38Dilated cardiomyopathy_Homo sapiens_hsa054141.37491003
39Serotonergic synapse_Homo sapiens_hsa047261.34649990
40Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.33370892
41Arginine biosynthesis_Homo sapiens_hsa002201.27854208
42Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.27155391
43Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.22587026
44Ribosome_Homo sapiens_hsa030101.19882042
45Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.18139564
46Maturity onset diabetes of the young_Homo sapiens_hsa049501.16781247
47Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.16138501
48Gastric acid secretion_Homo sapiens_hsa049711.14562689
49Glutamatergic synapse_Homo sapiens_hsa047241.12940590
50Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.12297719
51Cardiac muscle contraction_Homo sapiens_hsa042601.11378459
52cGMP-PKG signaling pathway_Homo sapiens_hsa040221.09918672
53Calcium signaling pathway_Homo sapiens_hsa040201.09181032
54Ether lipid metabolism_Homo sapiens_hsa005651.07615966
55Biosynthesis of amino acids_Homo sapiens_hsa012301.07406393
56* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.06751726
57Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.05185318
58Tryptophan metabolism_Homo sapiens_hsa003801.04676451
59Pancreatic secretion_Homo sapiens_hsa049721.04572419
60SNARE interactions in vesicular transport_Homo sapiens_hsa041301.03467544
61N-Glycan biosynthesis_Homo sapiens_hsa005101.03132774
62Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.02556665
63Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.02446947
64Bile secretion_Homo sapiens_hsa049761.00713236
65Carbohydrate digestion and absorption_Homo sapiens_hsa049731.00498117
66Fat digestion and absorption_Homo sapiens_hsa049751.00267126
67Propanoate metabolism_Homo sapiens_hsa006400.98237265
68Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.97213855
69Vascular smooth muscle contraction_Homo sapiens_hsa042700.87759978
70Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.85948919
71Basal transcription factors_Homo sapiens_hsa030220.82408340
72Dopaminergic synapse_Homo sapiens_hsa047280.80437293
73Melanogenesis_Homo sapiens_hsa049160.79736211
74Long-term depression_Homo sapiens_hsa047300.79314290
75Chemical carcinogenesis_Homo sapiens_hsa052040.77889879
76Protein digestion and absorption_Homo sapiens_hsa049740.75946209
77Arginine and proline metabolism_Homo sapiens_hsa003300.75941847
78Gap junction_Homo sapiens_hsa045400.75809998
79HIF-1 signaling pathway_Homo sapiens_hsa040660.75657295
80RNA degradation_Homo sapiens_hsa030180.72662819
81Fanconi anemia pathway_Homo sapiens_hsa034600.72005890
82Dorso-ventral axis formation_Homo sapiens_hsa043200.71546245
83Peroxisome_Homo sapiens_hsa041460.70258314
84Axon guidance_Homo sapiens_hsa043600.69958515
85Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.68241899
86Selenocompound metabolism_Homo sapiens_hsa004500.67433567
87Hippo signaling pathway_Homo sapiens_hsa043900.66682262
88mTOR signaling pathway_Homo sapiens_hsa041500.65823135
89Folate biosynthesis_Homo sapiens_hsa007900.64720999
90Taste transduction_Homo sapiens_hsa047420.64419813
91RNA polymerase_Homo sapiens_hsa030200.61531389
92Vitamin digestion and absorption_Homo sapiens_hsa049770.61468860
93* cAMP signaling pathway_Homo sapiens_hsa040240.61414038
94GnRH signaling pathway_Homo sapiens_hsa049120.60726256
95Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.60094793
96Mineral absorption_Homo sapiens_hsa049780.59674439
97Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.58639696
98Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58333680
99Arachidonic acid metabolism_Homo sapiens_hsa005900.58113878
100beta-Alanine metabolism_Homo sapiens_hsa004100.57008492
101Systemic lupus erythematosus_Homo sapiens_hsa053220.56944137
102Homologous recombination_Homo sapiens_hsa034400.55371789
103Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.55121665
104Leishmaniasis_Homo sapiens_hsa051400.55077018
105Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.54939594
106PPAR signaling pathway_Homo sapiens_hsa033200.54704537
107Wnt signaling pathway_Homo sapiens_hsa043100.54506559
108MAPK signaling pathway_Homo sapiens_hsa040100.53686850
109One carbon pool by folate_Homo sapiens_hsa006700.52663461
110Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.51116521
111Purine metabolism_Homo sapiens_hsa002300.50359179
112Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.49614758
113Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.48978355
114Caffeine metabolism_Homo sapiens_hsa002320.48133998
115Fatty acid metabolism_Homo sapiens_hsa012120.47912188
116Melanoma_Homo sapiens_hsa052180.44796648
117Regulation of autophagy_Homo sapiens_hsa041400.44709683
118Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.44590145
119Collecting duct acid secretion_Homo sapiens_hsa049660.44019097
120Non-homologous end-joining_Homo sapiens_hsa034500.42573049
121Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.42565944
122Rheumatoid arthritis_Homo sapiens_hsa053230.40000644
123Platelet activation_Homo sapiens_hsa046110.38655675
124Alcoholism_Homo sapiens_hsa050340.36709807
125Colorectal cancer_Homo sapiens_hsa052100.34836859
126Primary immunodeficiency_Homo sapiens_hsa053400.34768309
127DNA replication_Homo sapiens_hsa030300.33900947
128Acute myeloid leukemia_Homo sapiens_hsa052210.31602472
129Base excision repair_Homo sapiens_hsa034100.31383543
130AMPK signaling pathway_Homo sapiens_hsa041520.30729527
131Malaria_Homo sapiens_hsa051440.30647759
132Type II diabetes mellitus_Homo sapiens_hsa049300.30398430
133Inositol phosphate metabolism_Homo sapiens_hsa005620.29485088
134Ovarian steroidogenesis_Homo sapiens_hsa049130.28687386
135Longevity regulating pathway - mammal_Homo sapiens_hsa042110.27319684
136Cocaine addiction_Homo sapiens_hsa050300.26869040
137ABC transporters_Homo sapiens_hsa020100.26810212
138Notch signaling pathway_Homo sapiens_hsa043300.26133301
139Legionellosis_Homo sapiens_hsa051340.25772648
140Allograft rejection_Homo sapiens_hsa053300.25742996
141Autoimmune thyroid disease_Homo sapiens_hsa053200.25113974
142Jak-STAT signaling pathway_Homo sapiens_hsa046300.24847826
143Toll-like receptor signaling pathway_Homo sapiens_hsa046200.23057070
144Lysine degradation_Homo sapiens_hsa003100.22735070
145Hematopoietic cell lineage_Homo sapiens_hsa046400.21707062
146Endometrial cancer_Homo sapiens_hsa052130.18837021
147Measles_Homo sapiens_hsa051620.18662059
148Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.17246228
149Amphetamine addiction_Homo sapiens_hsa050310.16550016
150Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.15606967
151PI3K-Akt signaling pathway_Homo sapiens_hsa041510.14177892
152Mismatch repair_Homo sapiens_hsa034300.14040638
153Transcriptional misregulation in cancer_Homo sapiens_hsa052020.13676204

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