VKORC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the catalytic subunit of the vitamin K epoxide reductase complex, which is responsible for the reduction of inactive vitamin K 2,3-epoxide to active vitamin K in the endoplasmic reticulum membrane. Vitamin K is a required co-factor for carboxylation of glutamic acid residues by vitamin K-dependent gamma-carboxylase in blood-clotting enzymes. Allelic variation in this gene is associated with vitamin k-dependent clotting factors combined deficiency of 2, and increased resistance or sensitivity to warfarin, an inhibitor of vitamin K epoxide reductase. Pseudogenes of this gene are located on chromosomes 1 and X. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)7.26193087
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.26193087
3L-phenylalanine metabolic process (GO:0006558)6.92280592
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.92280592
5aromatic amino acid family catabolic process (GO:0009074)6.12255440
6protein maturation by protein folding (GO:0022417)5.51941773
7bile acid biosynthetic process (GO:0006699)5.28889751
8triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.25759018
9glyoxylate metabolic process (GO:0046487)5.19800322
10indole-containing compound catabolic process (GO:0042436)5.11396858
11indolalkylamine catabolic process (GO:0046218)5.11396858
12tryptophan catabolic process (GO:0006569)5.11396858
13tryptophan metabolic process (GO:0006568)4.93946636
14sulfur amino acid catabolic process (GO:0000098)4.82336106
15regulation of fibrinolysis (GO:0051917)4.76174559
16high-density lipoprotein particle remodeling (GO:0034375)4.72314902
17negative regulation of fibrinolysis (GO:0051918)4.72125112
18kynurenine metabolic process (GO:0070189)4.71706330
19cysteine metabolic process (GO:0006534)4.65453818
20* protein carboxylation (GO:0018214)4.64658340
21* peptidyl-glutamic acid carboxylation (GO:0017187)4.64658340
22regulation of protein activation cascade (GO:2000257)4.58225148
23alpha-linolenic acid metabolic process (GO:0036109)4.56586806
24aromatic amino acid family metabolic process (GO:0009072)4.50937683
25complement activation, alternative pathway (GO:0006957)4.49361108
26bile acid metabolic process (GO:0008206)4.48458764
27tyrosine metabolic process (GO:0006570)4.40694391
28aldehyde catabolic process (GO:0046185)4.35135285
29regulation of cholesterol esterification (GO:0010872)4.32662058
30regulation of complement activation (GO:0030449)4.31309692
31urea cycle (GO:0000050)4.27657506
32urea metabolic process (GO:0019627)4.27657506
33protein retention in ER lumen (GO:0006621)4.26277664
34serine family amino acid catabolic process (GO:0009071)4.15007063
35coenzyme catabolic process (GO:0009109)4.10635069
36triglyceride homeostasis (GO:0070328)4.10254856
37acylglycerol homeostasis (GO:0055090)4.10254856
38fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.07348618
39nitrogen cycle metabolic process (GO:0071941)4.04140073
40reverse cholesterol transport (GO:0043691)4.04072967
41opsonization (GO:0008228)4.03167718
42plasma lipoprotein particle remodeling (GO:0034369)4.01959622
43protein-lipid complex remodeling (GO:0034368)4.01959622
44macromolecular complex remodeling (GO:0034367)4.01959622
45regulation of triglyceride catabolic process (GO:0010896)4.01153471
46homocysteine metabolic process (GO:0050667)3.97237951
47maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.94598250
48blood coagulation, intrinsic pathway (GO:0007597)3.91886199
49cellular glucuronidation (GO:0052695)3.91312423
50alpha-amino acid catabolic process (GO:1901606)3.90404559
51cofactor catabolic process (GO:0051187)3.88295073
52fibrinolysis (GO:0042730)3.85733838
53serine family amino acid biosynthetic process (GO:0009070)3.85093267
54indolalkylamine metabolic process (GO:0006586)3.82573494
55cellular ketone body metabolic process (GO:0046950)3.80885409
56cellular biogenic amine catabolic process (GO:0042402)3.80764730
57amine catabolic process (GO:0009310)3.80764730
58phospholipid efflux (GO:0033700)3.78417348
59bile acid and bile salt transport (GO:0015721)3.77863879
60amino-acid betaine metabolic process (GO:0006577)3.77255970
61glycine metabolic process (GO:0006544)3.75938807
62plasma lipoprotein particle clearance (GO:0034381)3.70215863
63serine family amino acid metabolic process (GO:0009069)3.69551854
64chaperone-mediated protein transport (GO:0072321)3.69286941
65cellular amino acid catabolic process (GO:0009063)3.66498535
66glucuronate metabolic process (GO:0019585)3.65832103
67uronic acid metabolic process (GO:0006063)3.65832103
68imidazole-containing compound metabolic process (GO:0052803)3.61701172
69positive regulation of triglyceride lipase activity (GO:0061365)3.58390343
70positive regulation of lipoprotein lipase activity (GO:0051006)3.58390343
71cholesterol efflux (GO:0033344)3.57182409
724-hydroxyproline metabolic process (GO:0019471)3.55280447
73benzene-containing compound metabolic process (GO:0042537)3.53147945
74regulation of plasminogen activation (GO:0010755)3.51662288
75heme transport (GO:0015886)3.49061364
76fatty acid elongation (GO:0030497)3.47472413
77negative regulation of sterol transport (GO:0032372)3.47285430
78negative regulation of cholesterol transport (GO:0032375)3.47285430
79deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.43103285
80low-density lipoprotein particle remodeling (GO:0034374)3.41729850
81protein complex biogenesis (GO:0070271)3.36890803
82ethanol oxidation (GO:0006069)3.34849656
83lysine catabolic process (GO:0006554)3.34585667
84lysine metabolic process (GO:0006553)3.34585667
85carboxylic acid catabolic process (GO:0046395)3.34452796
86organic acid catabolic process (GO:0016054)3.34452796
87arginine metabolic process (GO:0006525)3.34094074
88protein activation cascade (GO:0072376)3.33811190
89very long-chain fatty acid metabolic process (GO:0000038)3.32683034
90cellular modified amino acid catabolic process (GO:0042219)3.32599445
91negative regulation of lipase activity (GO:0060192)3.32469467
92GDP-mannose metabolic process (GO:0019673)3.31819832
93ketone body metabolic process (GO:1902224)3.27391987
94L-serine metabolic process (GO:0006563)3.26757313
95short-chain fatty acid metabolic process (GO:0046459)3.26265351
96response to nitrosative stress (GO:0051409)3.25950822
97cholesterol homeostasis (GO:0042632)3.25152693
98plasma lipoprotein particle assembly (GO:0034377)3.24639546
99drug transmembrane transport (GO:0006855)3.23556937
100complement activation, classical pathway (GO:0006958)3.23246836
101complement activation (GO:0006956)3.23032340
102peptidyl-proline hydroxylation (GO:0019511)3.19675433
103sterol homeostasis (GO:0055092)3.17419705
104mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.17384368
105respiratory chain complex IV assembly (GO:0008535)3.16552512
106negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.16266259
107very-low-density lipoprotein particle assembly (GO:0034379)3.15691629
108monocarboxylic acid catabolic process (GO:0072329)3.13137171
109type B pancreatic cell proliferation (GO:0044342)3.11468568
110mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.11022973
111fatty acid beta-oxidation (GO:0006635)3.10060467
112cellular response to zinc ion (GO:0071294)3.08728672
113fatty acid oxidation (GO:0019395)3.08648846
114regulation of cholesterol metabolic process (GO:0090181)3.08090773
115fatty acid catabolic process (GO:0009062)3.07996567
116GTP biosynthetic process (GO:0006183)3.05315957
117regulation of mitochondrial translation (GO:0070129)3.02864529
118regulation of integrin-mediated signaling pathway (GO:2001044)3.02076225
119energy coupled proton transport, down electrochemical gradient (GO:0015985)3.00703389
120ATP synthesis coupled proton transport (GO:0015986)3.00703389
121mitochondrial respiratory chain complex assembly (GO:0033108)2.99067209
122positive regulation of TOR signaling (GO:0032008)2.98711615
123respiratory electron transport chain (GO:0022904)2.98495885
124cytochrome complex assembly (GO:0017004)2.95798365
125xenobiotic catabolic process (GO:0042178)2.95796577
126nucleobase-containing small molecule interconversion (GO:0015949)2.92964013
127guanosine-containing compound biosynthetic process (GO:1901070)2.92836347
128electron transport chain (GO:0022900)2.92482998
129protein neddylation (GO:0045116)2.90094835
130proteasome assembly (GO:0043248)2.89810350
131CTP biosynthetic process (GO:0006241)2.86541860
132CTP metabolic process (GO:0046036)2.86541860
133mitochondrial respiratory chain complex I assembly (GO:0032981)2.85893818
134NADH dehydrogenase complex assembly (GO:0010257)2.85893818
135mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.85893818
136protein targeting to mitochondrion (GO:0006626)2.85595590
137adhesion of symbiont to host cell (GO:0044650)2.84604619
138virion attachment to host cell (GO:0019062)2.84604619
139COPI coating of Golgi vesicle (GO:0048205)2.84554112
140Golgi transport vesicle coating (GO:0048200)2.84554112
141regulation of metalloenzyme activity (GO:0048552)2.78064938
142pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.75928827
143pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.74896356
144UTP biosynthetic process (GO:0006228)2.73947198
145L-ascorbic acid metabolic process (GO:0019852)2.73220658
146establishment of protein localization to mitochondrion (GO:0072655)2.69632155
147UTP metabolic process (GO:0046051)2.69117760
148adhesion of symbiont to host (GO:0044406)2.67278922
149pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.64929650
150positive regulation of mitochondrial fission (GO:0090141)2.63279030
151pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.61845725
152regulation of cellular amino acid metabolic process (GO:0006521)2.61454640
153establishment of protein localization to mitochondrial membrane (GO:0090151)2.59670109
154endosome to melanosome transport (GO:0035646)2.55718334
155endosome to pigment granule transport (GO:0043485)2.55718334
156mannosylation (GO:0097502)2.55690596
157cell redox homeostasis (GO:0045454)2.52673392
158response to redox state (GO:0051775)2.52478734
159protein hydroxylation (GO:0018126)2.51305272
160arginine catabolic process (GO:0006527)2.49734544
161protein localization to mitochondrion (GO:0070585)2.49165627
162regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.48132815
163pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.47398567
164negative regulation of mitochondrion organization (GO:0010823)2.46422266
165extracellular fibril organization (GO:0043206)2.46412792
166lipopolysaccharide biosynthetic process (GO:0009103)2.45126607
167keratan sulfate catabolic process (GO:0042340)2.44213402
168positive regulation of actin filament depolymerization (GO:0030836)2.43324588
169cullin deneddylation (GO:0010388)2.43297070
170regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.39623800
171dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.39621609
172daunorubicin metabolic process (GO:0044597)2.39458357
173polyketide metabolic process (GO:0030638)2.39458357
174doxorubicin metabolic process (GO:0044598)2.39458357
175branched-chain amino acid catabolic process (GO:0009083)2.39075203
176iron-sulfur cluster assembly (GO:0016226)2.38092087
177metallo-sulfur cluster assembly (GO:0031163)2.38092087
178platelet dense granule organization (GO:0060155)2.37930009
179nucleotide-sugar biosynthetic process (GO:0009226)2.33986887
180hyaluronan catabolic process (GO:0030214)2.33599682
1812-deoxyribonucleotide biosynthetic process (GO:0009265)2.33558506
182deoxyribose phosphate biosynthetic process (GO:0046385)2.33558506
183protein deneddylation (GO:0000338)2.32214461
184negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.30647206

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse6.94445364
2EGR1_23403033_ChIP-Seq_LIVER_Mouse6.31788465
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.84632715
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.18602141
5CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.16961906
6CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.21327792
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.17332673
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.15799195
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.98592742
10* HIF1A_21447827_ChIP-Seq_MCF-7_Human2.80489146
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.65545909
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.55084850
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.49855483
14THAP11_20581084_ChIP-Seq_MESCs_Mouse2.29229807
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.19927587
16HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.18766173
17GATA1_22025678_ChIP-Seq_K562_Human2.16095563
18PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.00867291
19ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.0476835
20TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.89880170
21CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.80070094
22PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.77168264
23STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.77027431
24GABP_17652178_ChIP-ChIP_JURKAT_Human1.76024733
25* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.69867125
26ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.68034914
27POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.67770839
28HTT_18923047_ChIP-ChIP_STHdh_Human1.64516858
29XRN2_22483619_ChIP-Seq_HELA_Human1.63404050
30ELF1_17652178_ChIP-ChIP_JURKAT_Human1.61676153
31* CTCF_18555785_ChIP-Seq_MESCs_Mouse1.59441992
32* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.58292486
33ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.57452498
34* SRF_21415370_ChIP-Seq_HL-1_Mouse1.54644852
35ZNF263_19887448_ChIP-Seq_K562_Human1.52103418
36YY1_21170310_ChIP-Seq_MESCs_Mouse1.51783492
37ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.50922419
38TET1_21451524_ChIP-Seq_MESCs_Mouse1.50412216
39SRY_22984422_ChIP-ChIP_TESTIS_Rat1.49290497
40CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.43250028
41DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.42755717
42NELFA_20434984_ChIP-Seq_ESCs_Mouse1.42697129
43TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.41058179
44E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.36895878
45TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.36310705
46ZFX_18555785_ChIP-Seq_MESCs_Mouse1.35786869
47TTF2_22483619_ChIP-Seq_HELA_Human1.35075442
48TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.34911705
49* SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.34227789
50TFEB_21752829_ChIP-Seq_HELA_Human1.33944041
51LXR_22292898_ChIP-Seq_THP-1_Human1.33027585
52NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.32865134
53ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.31719474
54MYC_19079543_ChIP-ChIP_MESCs_Mouse1.29722075
55CREB1_15753290_ChIP-ChIP_HEK293T_Human1.29064737
56DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.28629595
57IRF8_22096565_ChIP-ChIP_GC-B_Human1.28614358
58EST1_17652178_ChIP-ChIP_JURKAT_Human1.27042896
59* FOXP1_21924763_ChIP-Seq_HESCs_Human1.25637717
60TBX5_21415370_ChIP-Seq_HL-1_Mouse1.25476229
61NANOG_18555785_ChIP-Seq_MESCs_Mouse1.20557902
62ELK3_25401928_ChIP-Seq_HUVEC_Human1.20451707
63CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.15742297
64FOXP3_21729870_ChIP-Seq_TREG_Human1.15330074
65ELF1_20517297_ChIP-Seq_JURKAT_Human1.14857706
66KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.14252413
67TRIM28_21343339_ChIP-Seq_HEK293_Human1.13471231
68PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13204920
69RXRA_24833708_ChIP-Seq_LIVER_Mouse1.13178846
70ESR1_15608294_ChIP-ChIP_MCF-7_Human1.12197163
71TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08391963
72KAP1_22055183_ChIP-Seq_ESCs_Mouse1.08295837
73SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.07355440
74NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.06796270
75CLOCK_20551151_ChIP-Seq_293T_Human1.05195534
76* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.05117352
77* ATF3_27146783_Chip-Seq_COLON_Human1.04619260
78CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.04173280
79CTCF_20526341_ChIP-Seq_ESCs_Human1.02907441
80BCL6_27268052_Chip-Seq_Bcells_Human1.00240251
81AR_20517297_ChIP-Seq_VCAP_Human0.99100656
82* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.98640533
83ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.98504262
84* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.98084237
85VDR_23849224_ChIP-Seq_CD4+_Human0.96975193
86RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.96259056
87TP53_22127205_ChIP-Seq_IMR90_Human0.96148467
88MYCN_18555785_ChIP-Seq_MESCs_Mouse0.96023667
89MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.95705384
90* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.95240430
91SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.95225934
92RARG_19884340_ChIP-ChIP_MEFs_Mouse0.94733181
93KLF4_18555785_ChIP-Seq_MESCs_Mouse0.94685757
94HNF4A_19822575_ChIP-Seq_HepG2_Human0.94163926
95SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.93366976
96MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.92458149
97EOMES_21245162_ChIP-Seq_HESCs_Human0.92448175
98ELK1_19687146_ChIP-ChIP_HELA_Human0.92261060
99* ETS1_20019798_ChIP-Seq_JURKAT_Human0.91458386
100TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.90308456
101EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.88336827
102IRF1_19129219_ChIP-ChIP_H3396_Human0.87580894
103* MYC_18358816_ChIP-ChIP_MESCs_Mouse0.86723630
104GATA4_25053715_ChIP-Seq_YYC3_Human0.86589586
105CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.85807671
106CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.85321062
107SOX2_27498859_Chip-Seq_STOMACH_Mouse0.81923944
108* FOXA2_19822575_ChIP-Seq_HepG2_Human0.81922645
109NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.80330797
110RAD21_21589869_ChIP-Seq_MESCs_Mouse0.79080604
111SALL4_18804426_ChIP-ChIP_XEN_Mouse0.78561031
112STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.78528595
113BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.77651833
114ERG_20887958_ChIP-Seq_HPC-7_Mouse0.76350508
115LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.75340311
116FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.75109652
117DCP1A_22483619_ChIP-Seq_HELA_Human0.75040769
118AUTS2_25519132_ChIP-Seq_293T-REX_Human0.74493847
119PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.73719733
120ERG_20517297_ChIP-Seq_VCAP_Human0.71585936
121NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.71217045
122NRF2_20460467_ChIP-Seq_MEFs_Mouse0.71217045
123FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.71092637
124ESR1_21235772_ChIP-Seq_MCF-7_Human0.70682430
125FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.69287737
126PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.68730213
127SOX17_20123909_ChIP-Seq_XEN_Mouse0.68458331
128SOX2_20726797_ChIP-Seq_SW620_Human0.68122208
129RARB_24833708_ChIP-Seq_LIVER_Mouse0.66497157
130PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.65872300
131CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.65341267
132SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.64767650
133MYC_18555785_ChIP-Seq_MESCs_Mouse0.64588383
134THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.63468454
135NANOG_20526341_ChIP-Seq_ESCs_Human0.63300970
136RARA_24833708_ChIP-Seq_LIVER_Mouse0.62791235
137PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.61329151
138HOXB4_20404135_ChIP-ChIP_EML_Mouse0.60929679
139SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.60213214
140GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.60163258
141PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.59953862
142RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.59369505
143CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.57864828
144RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.57004718
145CEBPB_22108803_ChIP-Seq_LS180_Human0.56975865
146* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.56650409
147P53_21459846_ChIP-Seq_SAOS-2_Human0.56272585
148ESET_19884257_ChIP-Seq_ESCs_Mouse0.55652164
149HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.54883294
150CSB_26484114_Chip-Seq_FIBROBLAST_Human0.54688624
151FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.52783387
152RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.52741072
153STAT1_17558387_ChIP-Seq_HELA_Human0.52601523
154PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.52206902
155GABP_19822575_ChIP-Seq_HepG2_Human0.51971676
156SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.51643947

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.50908741
2MP0005360_urolithiasis6.28996068
3MP0005085_abnormal_gallbladder_physiolo5.60363662
4MP0005365_abnormal_bile_salt5.59027266
5MP0003806_abnormal_nucleotide_metabolis4.78360715
6MP0008875_abnormal_xenobiotic_pharmacok4.50605315
7MP0003195_calcinosis3.50312420
8MP0003252_abnormal_bile_duct3.25362605
9MP0009840_abnormal_foam_cell3.07843481
10MP0005257_abnormal_intraocular_pressure3.02192002
11MP0010329_abnormal_lipoprotein_level2.88920988
12MP0005083_abnormal_biliary_tract2.79221524
13MP0006054_spinal_hemorrhage2.69639147
14MP0005332_abnormal_amino_acid2.60661251
15MP0004272_abnormal_basement_membrane2.54858971
16MP0003279_aneurysm2.52616303
17MP0001666_abnormal_nutrient_absorption2.52163290
18MP0010030_abnormal_orbit_morphology2.49285401
19MP0000372_irregular_coat_pigmentation2.38229090
20MP0003123_paternal_imprinting2.18784029
21MP0003191_abnormal_cellular_cholesterol2.04473209
22MP0003950_abnormal_plasma_membrane2.01058355
23MP0003186_abnormal_redox_activity1.99492572
24MP0009697_abnormal_copulation1.98951953
25MP0002118_abnormal_lipid_homeostasis1.90274271
26MP0005451_abnormal_body_composition1.86581842
27MP0001764_abnormal_homeostasis1.84907453
28MP0002938_white_spotting1.83007118
29MP0000609_abnormal_liver_physiology1.81928024
30MP0003868_abnormal_feces_composition1.81338266
31MP0004019_abnormal_vitamin_homeostasis1.80582630
32MP0002138_abnormal_hepatobiliary_system1.66416180
33MP0002163_abnormal_gland_morphology1.65830531
34MP0005319_abnormal_enzyme/_coenzyme1.63480440
35MP0003011_delayed_dark_adaptation1.57667425
36MP0003656_abnormal_erythrocyte_physiolo1.57192283
37MP0003122_maternal_imprinting1.54194492
38MP0005408_hypopigmentation1.53917741
39MP0003172_abnormal_lysosome_physiology1.48308875
40MP0009780_abnormal_chondrocyte_physiolo1.48219984
41MP0008438_abnormal_cutaneous_collagen1.46876719
42MP0010386_abnormal_urinary_bladder1.44135276
43MP0009643_abnormal_urine_homeostasis1.42544554
44MP0005584_abnormal_enzyme/coenzyme_acti1.41265282
45MP0005220_abnormal_exocrine_pancreas1.37269598
46MP0000013_abnormal_adipose_tissue1.31462715
47MP0005171_absent_coat_pigmentation1.31000146
48MP0005084_abnormal_gallbladder_morpholo1.29590400
49MP0000003_abnormal_adipose_tissue1.27314256
50MP0005508_abnormal_skeleton_morphology1.26863854
51MP0005503_abnormal_tendon_morphology1.23106680
52MP0005636_abnormal_mineral_homeostasis1.20037368
53MP0000358_abnormal_cell_content/1.19141427
54MP0001958_emphysema1.18764340
55MP0000343_altered_response_to1.18722766
56MP0003724_increased_susceptibility_to1.17530940
57MP0010368_abnormal_lymphatic_system1.11082689
58MP0003718_maternal_effect1.07731722
59MP0000598_abnormal_liver_morphology1.07722417
60MP0001905_abnormal_dopamine_level1.06835889
61MP0006036_abnormal_mitochondrial_physio1.06457545
62MP0002837_dystrophic_cardiac_calcinosis1.03242221
63MP0009763_increased_sensitivity_to0.99379005
64MP0003786_premature_aging0.99179120
65MP0008469_abnormal_protein_level0.98383352
66MP0001542_abnormal_bone_strength0.97879714
67MP0009379_abnormal_foot_pigmentation0.96753698
68MP0005623_abnormal_meninges_morphology0.93449721
69MP0005647_abnormal_sex_gland0.90833936
70MP0009384_cardiac_valve_regurgitation0.90594580
71MP0009764_decreased_sensitivity_to0.89070769
72MP0002090_abnormal_vision0.88890513
73MP0005058_abnormal_lysosome_morphology0.88724201
74MP0001661_extended_life_span0.88531377
75MP0000015_abnormal_ear_pigmentation0.86687042
76MP0000681_abnormal_thyroid_gland0.86299183
77MP0001529_abnormal_vocalization0.84154238
78MP0008260_abnormal_autophagy0.83771748
79* MP0009642_abnormal_blood_homeostasis0.83662203
80MP0002876_abnormal_thyroid_physiology0.83539698
81MP0000750_abnormal_muscle_regeneration0.83290511
82MP0009765_abnormal_xenobiotic_induced0.83112885
83MP0005376_homeostasis/metabolism_phenot0.82416538
84MP0005197_abnormal_uvea_morphology0.81772375
85MP0008789_abnormal_olfactory_epithelium0.81572952
86MP0000639_abnormal_adrenal_gland0.81542707
87MP0002295_abnormal_pulmonary_circulatio0.80925878
88MP0002909_abnormal_adrenal_gland0.80694636
89MP0003942_abnormal_urinary_system0.79174283
90MP0005193_abnormal_anterior_eye0.78244249
91MP0004858_abnormal_nervous_system0.77677574
92MP0003566_abnormal_cell_adhesion0.75772885
93MP0005670_abnormal_white_adipose0.75174430
94MP0001243_abnormal_dermal_layer0.74496755
95MP0004381_abnormal_hair_follicle0.74253540
96MP0008932_abnormal_embryonic_tissue0.73580550
97MP0002060_abnormal_skin_morphology0.73325226
98MP0000604_amyloidosis0.72971805
99MP0002933_joint_inflammation0.72829177
100MP0004043_abnormal_pH_regulation0.72165164
101MP0005165_increased_susceptibility_to0.72017379
102MP0003121_genomic_imprinting0.70971979
103MP0005395_other_phenotype0.70880809
104MP0005379_endocrine/exocrine_gland_phen0.70684509
105MP0001756_abnormal_urination0.69833505
106MP0005275_abnormal_skin_tensile0.68410211
107MP0002078_abnormal_glucose_homeostasis0.68405614
108MP0004147_increased_porphyrin_level0.67476288
109MP0002160_abnormal_reproductive_system0.65826681
110MP0002254_reproductive_system_inflammat0.64641449
111MP0003075_altered_response_to0.63937277
112MP0001324_abnormal_eye_pigmentation0.63825963
113MP0009250_abnormal_appendicular_skeleto0.63746424
114MP0005410_abnormal_fertilization0.62465178
115MP0006082_CNS_inflammation0.61487195
116MP0009053_abnormal_anal_canal0.61251130
117MP0003638_abnormal_response/metabolism_0.60921647
118MP0005646_abnormal_pituitary_gland0.60055401
119MP0006292_abnormal_olfactory_placode0.59846979
120MP0004782_abnormal_surfactant_physiolog0.59284632
121MP0001533_abnormal_skeleton_physiology0.59132500
122MP0005075_abnormal_melanosome_morpholog0.58453971
123MP0003690_abnormal_glial_cell0.57815314
124MP0005464_abnormal_platelet_physiology0.57584954
125MP0001944_abnormal_pancreas_morphology0.56785894
126MP0005164_abnormal_response_to0.55240054
127MP0003705_abnormal_hypodermis_morpholog0.54504037
128MP0003436_decreased_susceptibility_to0.53482393
129MP0000230_abnormal_systemic_arterial0.52247734
130MP0002132_abnormal_respiratory_system0.51690491
131MP0004134_abnormal_chest_morphology0.51389729
132MP0000163_abnormal_cartilage_morphology0.50946492
133MP0000920_abnormal_myelination0.50673192
134MP0005266_abnormal_metabolism0.49719267
135MP0005334_abnormal_fat_pad0.47036565
136MP0005535_abnormal_body_temperature0.45187712
137MP0002136_abnormal_kidney_physiology0.44955965
138MP0008873_increased_physiological_sensi0.43757473
139MP0000613_abnormal_salivary_gland0.42923032
140MP0006035_abnormal_mitochondrial_morpho0.40537929
141MP0005023_abnormal_wound_healing0.39883025
142MP0005595_abnormal_vascular_smooth0.39865431
143MP0001845_abnormal_inflammatory_respons0.39501148
144MP0000566_synostosis0.38575122
145MP0005390_skeleton_phenotype0.36986875
146MP0002971_abnormal_brown_adipose0.36933785
147MP0003953_abnormal_hormone_level0.36740369
148MP0000579_abnormal_nail_morphology0.36618091
149MP0000538_abnormal_urinary_bladder0.36544983
150MP0002693_abnormal_pancreas_physiology0.35314658

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.26218508
2Intrahepatic cholestasis (HP:0001406)6.21929188
3Prolonged partial thromboplastin time (HP:0003645)5.87505123
4Deep venous thrombosis (HP:0002625)5.68073900
5Abnormality of monocarboxylic acid metabolism (HP:0010996)5.31403301
6Xanthomatosis (HP:0000991)5.06377384
7Hypobetalipoproteinemia (HP:0003563)5.02094313
8Premature rupture of membranes (HP:0001788)4.83687699
9Hyperlipoproteinemia (HP:0010980)4.55039746
10Complement deficiency (HP:0004431)4.22915947
11Hypoglycemic coma (HP:0001325)4.08951514
12Joint hemorrhage (HP:0005261)3.89685967
13Fat malabsorption (HP:0002630)3.81784509
14Abnormality of methionine metabolism (HP:0010901)3.81596934
15Protrusio acetabuli (HP:0003179)3.73138582
16Hypolipoproteinemia (HP:0010981)3.67840936
17Hyperammonemia (HP:0001987)3.65041277
18Hyperglycinemia (HP:0002154)3.64861077
19Ketosis (HP:0001946)3.61085938
20Acute necrotizing encephalopathy (HP:0006965)3.58215814
21* Abnormality of the common coagulation pathway (HP:0010990)3.55326021
22Abnormality of aspartate family amino acid metabolism (HP:0010899)3.53553293
23Abnormal mitochondria in muscle tissue (HP:0008316)3.52728699
24Vertebral compression fractures (HP:0002953)3.51064655
25* Abnormality of the intrinsic pathway (HP:0010989)3.45914359
26Conjugated hyperbilirubinemia (HP:0002908)3.42928479
27Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.39909761
28Abnormality of sulfur amino acid metabolism (HP:0004339)3.37704655
29Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.33634912
30Abnormality of fatty-acid metabolism (HP:0004359)3.30697145
31Mitochondrial inheritance (HP:0001427)3.28502135
32Abnormality of glycolysis (HP:0004366)3.24072032
33Steatorrhea (HP:0002570)3.21449144
34Generalized aminoaciduria (HP:0002909)3.18021054
35Prolonged neonatal jaundice (HP:0006579)3.17880159
36Abnormality of complement system (HP:0005339)3.16773145
37Abnormality of serine family amino acid metabolism (HP:0010894)3.16272445
38Abnormality of glycine metabolism (HP:0010895)3.16272445
39Hypoalphalipoproteinemia (HP:0003233)3.14246311
40Abnormality of glutamine family amino acid metabolism (HP:0010902)3.09933106
41Abnormality of liposaccharide metabolism (HP:0010968)3.07994367
42Abnormality of glycosphingolipid metabolism (HP:0004343)3.07994367
43Abnormality of glycolipid metabolism (HP:0010969)3.07994367
44Increased serum pyruvate (HP:0003542)3.05340565
45Hyperbilirubinemia (HP:0002904)3.01715370
46Epidermoid cyst (HP:0200040)3.00977425
47Hyperglycinuria (HP:0003108)2.95360859
48Increased CSF lactate (HP:0002490)2.88953266
49Abnormality of pyrimidine metabolism (HP:0004353)2.84793414
50Dicarboxylic aciduria (HP:0003215)2.81686677
51Abnormality of dicarboxylic acid metabolism (HP:0010995)2.81686677
52Cerebral edema (HP:0002181)2.78808605
53Abnormal tarsal ossification (HP:0008369)2.77235887
54Progressive macrocephaly (HP:0004481)2.77227319
55Delayed CNS myelination (HP:0002188)2.76998970
56Systemic lupus erythematosus (HP:0002725)2.75607865
57Hypoglycemic seizures (HP:0002173)2.69916356
58Follicular hyperkeratosis (HP:0007502)2.69748430
59Abnormality of serum amino acid levels (HP:0003112)2.67124178
60Lethargy (HP:0001254)2.66781184
61Abnormality of dentin (HP:0010299)2.66460506
62Ketoacidosis (HP:0001993)2.64560465
63Type I transferrin isoform profile (HP:0003642)2.59845358
64Ankle contracture (HP:0006466)2.58193020
65Hepatic necrosis (HP:0002605)2.54587099
66Dysostosis multiplex (HP:0000943)2.51623417
67Spontaneous abortion (HP:0005268)2.50987268
68Opisthotonus (HP:0002179)2.50739521
69Hypercholesterolemia (HP:0003124)2.50551196
70Decreased activity of mitochondrial respiratory chain (HP:0008972)2.50405606
71Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.50405606
72Metabolic acidosis (HP:0001942)2.46511682
73Abnormality of nucleobase metabolism (HP:0010932)2.41852428
74Cervical subluxation (HP:0003308)2.41198014
75Abnormality of mucopolysaccharide metabolism (HP:0011020)2.39784804
76Abnormality of polysaccharide metabolism (HP:0011012)2.39784804
77Abnormality of glycosaminoglycan metabolism (HP:0004371)2.39784804
78Acute encephalopathy (HP:0006846)2.35530235
79Glycosuria (HP:0003076)2.34332837
80Abnormality of urine glucose concentration (HP:0011016)2.34332837
81Beaking of vertebral bodies (HP:0004568)2.31555148
82Soft skin (HP:0000977)2.31374387
83Brushfield spots (HP:0001088)2.27695717
84Nuclear cataract (HP:0100018)2.26790364
85Hepatocellular carcinoma (HP:0001402)2.25379559
86Mucopolysacchariduria (HP:0008155)2.24155628
87Urinary glycosaminoglycan excretion (HP:0003541)2.24155628
88Hyperinsulinemic hypoglycemia (HP:0000825)2.23875977
89Symptomatic seizures (HP:0011145)2.22572971
90Glomerulonephritis (HP:0000099)2.22380633
91Abnormality of purine metabolism (HP:0004352)2.20381935
92Amyloidosis (HP:0011034)2.19980292
93Progressive neurologic deterioration (HP:0002344)2.18086199
94Respiratory failure (HP:0002878)2.17549076
95Irritability (HP:0000737)2.16451130
96Exercise intolerance (HP:0003546)2.14200658
97Vomiting (HP:0002013)2.12942449
98Vascular calcification (HP:0004934)2.12643170
99Reduced antithrombin III activity (HP:0001976)2.12086343
100Hypokinesia (HP:0002375)2.11883108
101Hand muscle atrophy (HP:0009130)2.11867486
102Lactic acidosis (HP:0003128)2.11430368
103Enlarged kidneys (HP:0000105)2.11098860
104Pancreatitis (HP:0001733)2.10866957
105Renal Fanconi syndrome (HP:0001994)2.08831552
106Protuberant abdomen (HP:0001538)2.07560930
107Increased serum lactate (HP:0002151)2.04670975
108Abnormal cartilage morphology (HP:0002763)2.04033442
109Malnutrition (HP:0004395)2.03443708
110Renal cortical cysts (HP:0000803)2.03013365
111Abnormal protein glycosylation (HP:0012346)2.02124801
112Abnormal glycosylation (HP:0012345)2.02124801
113Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.02124801
114Abnormal protein N-linked glycosylation (HP:0012347)2.02124801
115Gout (HP:0001997)1.98384244
116Late onset (HP:0003584)1.98094081
117Redundant skin (HP:0001582)1.97859483
118Myocardial infarction (HP:0001658)1.97804195
119Purpura (HP:0000979)1.96853682
120Cardiovascular calcification (HP:0011915)1.95845385
121Increased intramyocellular lipid droplets (HP:0012240)1.95251730
122Joint stiffness (HP:0001387)1.94837572
123Skin nodule (HP:0200036)1.93990670
124Microvesicular hepatic steatosis (HP:0001414)1.93954825
125Increased hepatocellular lipid droplets (HP:0006565)1.93781759
126Hepatocellular necrosis (HP:0001404)1.93526790
127Menorrhagia (HP:0000132)1.92413873
128Irregular epiphyses (HP:0010582)1.91947358
129Abnormal gallbladder morphology (HP:0012437)1.91937092
130Proximal tubulopathy (HP:0000114)1.90153035
131Blue sclerae (HP:0000592)1.87590786
132Spastic paraparesis (HP:0002313)1.86502379
133Cholecystitis (HP:0001082)1.86410393
134Abnormal gallbladder physiology (HP:0012438)1.86410393
1353-Methylglutaconic aciduria (HP:0003535)1.85920973
136Abnormality of the Achilles tendon (HP:0005109)1.84537816
137Lipid accumulation in hepatocytes (HP:0006561)1.83338147
138Gingival bleeding (HP:0000225)1.82567075
139Exertional dyspnea (HP:0002875)1.82137582
140J-shaped sella turcica (HP:0002680)1.81305400
141Epiphyseal stippling (HP:0010655)1.81066545
142Vacuolated lymphocytes (HP:0001922)1.80155474
143Mitral stenosis (HP:0001718)1.80045550
144Rickets (HP:0002748)1.79176099
145Hypophosphatemic rickets (HP:0004912)1.79068565
146Abnormal enzyme/coenzyme activity (HP:0012379)1.78970952
147Petechiae (HP:0000967)1.78391497
148Testicular atrophy (HP:0000029)1.78312419
149Hyperglycemia (HP:0003074)1.78247040
150Hyperthyroidism (HP:0000836)1.77525161
151Generalized amyotrophy (HP:0003700)1.77247960
152Elevated hepatic transaminases (HP:0002910)1.77247697
153Microretrognathia (HP:0000308)1.76221577
154Abnormality of iron homeostasis (HP:0011031)1.75367040
155Craniofacial dystonia (HP:0012179)1.74962312
156Distal upper limb amyotrophy (HP:0007149)1.74452703
157Upper limb amyotrophy (HP:0009129)1.74452703
158Elbow flexion contracture (HP:0002987)1.72614008
159Adrenal hypoplasia (HP:0000835)1.72569549
160Hypoplasia of the capital femoral epiphysis (HP:0003090)1.72150216
161Delayed gross motor development (HP:0002194)1.72145224
162Abnormal delivery (HP:0001787)1.70107132
163Emotional lability (HP:0000712)1.68200631
164Focal dystonia (HP:0004373)1.67513604
165Increased muscle lipid content (HP:0009058)1.67057149

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.28318431
2TESK14.00922357
3LIMK13.81319447
4VRK23.47334654
5ERN13.39243669
6INSRR2.96172075
7NME22.89695545
8STK162.65965411
9TAOK32.65544071
10MAPK152.37930367
11PIK3CG2.36540508
12MAP4K22.28379189
13FGFR42.25319928
14SIK12.20446188
15PBK2.07788331
16MAP3K32.02232667
17ERBB41.92550889
18EIF2AK31.84001197
19DDR21.82538928
20PIM21.81958368
21FLT31.78046545
22PDK21.77381207
23IRAK31.73896719
24ABL21.70418895
25BUB11.69826114
26STK391.64154980
27ILK1.60679112
28MET1.59961744
29MAPKAPK51.53021700
30PAK41.44840578
31EPHB21.41142822
32EPHB11.39964465
33EIF2AK11.36175263
34KDR1.35344639
35ARAF1.33975367
36PTK21.33531921
37MST1R1.30111060
38WNK41.28920265
39MAP3K121.24007144
40PRKD31.21644672
41DAPK31.17300609
42DAPK11.16921869
43TIE11.15962384
44TRIM281.15262894
45VRK11.14652463
46BMPR1B1.14634311
47PAK11.13499930
48IRAK41.12371678
49NEK11.11525563
50NEK91.09915667
51TYK21.08407890
52IRAK11.08021167
53BRSK11.06977167
54BRAF1.05928218
55STK38L1.04925517
56MAP2K31.03848253
57AURKA0.99949441
58OXSR10.99374630
59FRK0.99212270
60MAP2K20.96781562
61MAPK110.96396901
62LMTK20.95372348
63TGFBR20.92790307
64MAP2K70.92023586
65EPHA30.90766514
66PINK10.89442527
67BMPR20.88277744
68CSNK1G10.87362830
69CSNK1G30.86461241
70TBK10.84464591
71ACVR1B0.84033455
72ADRBK20.82447491
73PLK30.82162574
74TAOK20.80961494
75NLK0.80692801
76KIT0.79645778
77PKN20.79457394
78MUSK0.79165462
79TESK20.76664311
80PAK20.76345671
81MYLK0.75931764
82TGFBR10.73464818
83DYRK20.73463746
84IKBKB0.70707847
85PASK0.69431413
86TEC0.69200637
87MAPKAPK30.68799920
88IKBKE0.68529822
89NUAK10.68413700
90PRKCI0.67911849
91PRKD20.66404378
92MAPK40.64596431
93MAP3K110.64161878
94PRKG20.63821348
95GRK50.63790311
96CAMK2G0.63601357
97PLK40.62079079
98MAP2K60.61490904
99RPS6KA40.60026536
100GRK10.59801128
101WNK30.58625331
102CDK140.57218785
103PLK20.56901460
104PLK10.55667218
105ADRBK10.55008330
106FGFR20.54432524
107PAK30.52713032
108GSK3A0.52320923
109PRKCG0.52066003
110TRPM70.51127350
111IRAK20.50682670
112EPHA20.50653035
113MST40.50498936
114RPS6KA50.50293513
115CAMK2D0.50125458
116BTK0.49928195
117CSNK1A1L0.49364291
118GRK70.49330431
119PAK60.47789720
120ZAK0.47707926
121BMX0.47335620
122LRRK20.45013531
123MOS0.44934054
124ZAP700.44386009
125CSNK2A20.44042745
126PRKCE0.43964861
127AKT20.43387685
128JAK20.43040461
129CDK11A0.42755371
130CDK150.41671359
131PHKG20.40961601
132PHKG10.40961601
133CDK180.40433288
134CSNK2A10.40206818
135EIF2AK20.39581318
136MAP3K80.38971895
137MAP3K60.37216184
138LYN0.36263801
139CSF1R0.35700534
140DYRK30.35565929
141CDK80.35388094
142LATS10.34899453
143BRSK20.34649644
144STK40.34303466
145BLK0.34264977
146CDK190.32561206
147ERBB20.32472478
148PRKAA20.31638217
149CDK70.31503717
150MAPK70.31131750
151MAP3K140.30097910
152TNIK0.29943936
153IGF1R0.29849940
154CSNK1G20.29226879
155PTK2B0.29221695
156AURKB0.29203982
157CHEK20.29182390
158STK380.28240147
159STK30.26941496
160PRKD10.26265729

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.00219728
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.98151288
3Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.71693542
4Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.60738935
5Complement and coagulation cascades_Homo sapiens_hsa046102.46693022
6Tryptophan metabolism_Homo sapiens_hsa003802.38835893
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.37470924
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.33190186
9Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.24215956
10Pentose and glucuronate interconversions_Homo sapiens_hsa000402.23074404
11Nitrogen metabolism_Homo sapiens_hsa009102.17202882
12Fatty acid degradation_Homo sapiens_hsa000712.16833030
13Arginine biosynthesis_Homo sapiens_hsa002202.16304722
14Sulfur metabolism_Homo sapiens_hsa009202.15017409
15Peroxisome_Homo sapiens_hsa041462.12576364
16Folate biosynthesis_Homo sapiens_hsa007902.09880888
17Fatty acid elongation_Homo sapiens_hsa000622.08509744
18Histidine metabolism_Homo sapiens_hsa003402.07396772
19Chemical carcinogenesis_Homo sapiens_hsa052042.00377297
20Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.00132743
21Butanoate metabolism_Homo sapiens_hsa006501.97758067
22Steroid biosynthesis_Homo sapiens_hsa001001.96318603
23Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.92825407
24Steroid hormone biosynthesis_Homo sapiens_hsa001401.92325477
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.90822907
26Protein export_Homo sapiens_hsa030601.86939945
27Maturity onset diabetes of the young_Homo sapiens_hsa049501.85414124
28Propanoate metabolism_Homo sapiens_hsa006401.77487316
29Drug metabolism - other enzymes_Homo sapiens_hsa009831.75518131
30* Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.73830326
31Retinol metabolism_Homo sapiens_hsa008301.64752779
32Fatty acid metabolism_Homo sapiens_hsa012121.61992104
33Vibrio cholerae infection_Homo sapiens_hsa051101.54477936
34Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.54026333
35Staphylococcus aureus infection_Homo sapiens_hsa051501.53956705
36beta-Alanine metabolism_Homo sapiens_hsa004101.53792317
37Selenocompound metabolism_Homo sapiens_hsa004501.51136964
38Tyrosine metabolism_Homo sapiens_hsa003501.46598585
39Caffeine metabolism_Homo sapiens_hsa002321.43955827
40PPAR signaling pathway_Homo sapiens_hsa033201.43282544
41Phenylalanine metabolism_Homo sapiens_hsa003601.41764175
42Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.32294600
43Arginine and proline metabolism_Homo sapiens_hsa003301.24442457
44Base excision repair_Homo sapiens_hsa034101.23569007
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.22907431
46Pyruvate metabolism_Homo sapiens_hsa006201.22449501
47Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.20304020
48Glutathione metabolism_Homo sapiens_hsa004801.17077523
49Sulfur relay system_Homo sapiens_hsa041221.14656076
50Starch and sucrose metabolism_Homo sapiens_hsa005001.13767883
51Vitamin B6 metabolism_Homo sapiens_hsa007501.12386759
52Collecting duct acid secretion_Homo sapiens_hsa049661.10848430
53Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.10251865
54Fat digestion and absorption_Homo sapiens_hsa049751.07543254
55Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.02979677
56DNA replication_Homo sapiens_hsa030300.98065213
57ABC transporters_Homo sapiens_hsa020100.97250765
58Vitamin digestion and absorption_Homo sapiens_hsa049770.96371219
59Cyanoamino acid metabolism_Homo sapiens_hsa004600.92223930
602-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.91010256
61Biosynthesis of amino acids_Homo sapiens_hsa012300.90604483
62Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.88048102
63Mismatch repair_Homo sapiens_hsa034300.87860605
64Bile secretion_Homo sapiens_hsa049760.87751021
65Carbon metabolism_Homo sapiens_hsa012000.86937668
66One carbon pool by folate_Homo sapiens_hsa006700.80963585
67Linoleic acid metabolism_Homo sapiens_hsa005910.77865941
68Metabolic pathways_Homo sapiens_hsa011000.75950379
69Nucleotide excision repair_Homo sapiens_hsa034200.73824437
70Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.71557224
71alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.70760392
72Mineral absorption_Homo sapiens_hsa049780.70574029
73Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.69795485
74Oxidative phosphorylation_Homo sapiens_hsa001900.68529331
75Cardiac muscle contraction_Homo sapiens_hsa042600.68230538
76Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.68003565
77Ribosome_Homo sapiens_hsa030100.67890345
78Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.63316669
79Pentose phosphate pathway_Homo sapiens_hsa000300.61045554
80Arachidonic acid metabolism_Homo sapiens_hsa005900.58125945
81Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.55999587
82Proteasome_Homo sapiens_hsa030500.55804207
83Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.55405729
84Synaptic vesicle cycle_Homo sapiens_hsa047210.54854851
85Homologous recombination_Homo sapiens_hsa034400.53851828
86Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53676567
87Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.51372811
88Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.48667721
89Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.47727205
90Glycerolipid metabolism_Homo sapiens_hsa005610.46378948
91Parkinsons disease_Homo sapiens_hsa050120.46331238
92Other glycan degradation_Homo sapiens_hsa005110.46203982
93Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.45946169
94Pyrimidine metabolism_Homo sapiens_hsa002400.44785912
95Galactose metabolism_Homo sapiens_hsa000520.43621106
96ECM-receptor interaction_Homo sapiens_hsa045120.40221359
97Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.39456476
98Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.38702166
99Lysine degradation_Homo sapiens_hsa003100.37486627
100Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.34784845
101Ether lipid metabolism_Homo sapiens_hsa005650.34293054
102Renin-angiotensin system_Homo sapiens_hsa046140.33009652
103RNA polymerase_Homo sapiens_hsa030200.31733699
104Prion diseases_Homo sapiens_hsa050200.29153292
105Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.27184729
106Glycosaminoglycan degradation_Homo sapiens_hsa005310.25066029
107Sphingolipid metabolism_Homo sapiens_hsa006000.22256937
108Fructose and mannose metabolism_Homo sapiens_hsa000510.21979139
109Alzheimers disease_Homo sapiens_hsa050100.20799195
110N-Glycan biosynthesis_Homo sapiens_hsa005100.19352400
111Regulation of autophagy_Homo sapiens_hsa041400.19232980
112Lysosome_Homo sapiens_hsa041420.13212147
113Huntingtons disease_Homo sapiens_hsa050160.13152268
114Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.12844690
115SNARE interactions in vesicular transport_Homo sapiens_hsa041300.12586410
116Glycerophospholipid metabolism_Homo sapiens_hsa005640.12092305
117Protein digestion and absorption_Homo sapiens_hsa049740.10286401
118Ovarian steroidogenesis_Homo sapiens_hsa049130.09556853
119Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.07033999
120Purine metabolism_Homo sapiens_hsa002300.04900189

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