VKORC1L1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an enzyme important in the vitamin K cycle, which is involved in the carboxylation of glutamate residues present in vitamin K-dependent proteins. The encoded enzyme catalyzes the de-epoxidation of vitamin K 2,3-epoxide. Oxidative stress may upregulate expression of this gene and the encoded protein may protect cells and membrane proteins form oxidative damage. This gene and a related gene (Gene ID: 79001) may have arisen by gene duplication of an ancestral gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1alpha-linolenic acid metabolic process (GO:0036109)4.02316550
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.72748047
3L-phenylalanine catabolic process (GO:0006559)3.72748047
4regulation of sequestering of triglyceride (GO:0010889)3.59208696
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.55472661
6L-phenylalanine metabolic process (GO:0006558)3.55472661
7cysteine metabolic process (GO:0006534)3.52199877
8serine family amino acid catabolic process (GO:0009071)3.49873334
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.44209756
10fatty acid homeostasis (GO:0055089)3.41634779
11glutamate metabolic process (GO:0006536)3.34250102
12fatty-acyl-CoA biosynthetic process (GO:0046949)3.29365537
13long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.24516391
14layer formation in cerebral cortex (GO:0021819)3.23874448
15lysine metabolic process (GO:0006553)3.19677219
16lysine catabolic process (GO:0006554)3.19677219
17regulation of short-term neuronal synaptic plasticity (GO:0048172)3.18244917
18CDP-diacylglycerol biosynthetic process (GO:0016024)3.16990325
19glucocorticoid receptor signaling pathway (GO:0042921)3.14421874
20glycine metabolic process (GO:0006544)3.13219723
21neutral lipid catabolic process (GO:0046461)3.12280682
22acylglycerol catabolic process (GO:0046464)3.12280682
23regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)3.11075287
24synaptic vesicle maturation (GO:0016188)3.06150676
25sulfur amino acid catabolic process (GO:0000098)3.04900029
26pyrimidine nucleobase catabolic process (GO:0006208)3.04737291
27CDP-diacylglycerol metabolic process (GO:0046341)3.01668765
28dicarboxylic acid biosynthetic process (GO:0043650)3.00174066
29triglyceride catabolic process (GO:0019433)2.99681744
30positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.98571460
31thioester biosynthetic process (GO:0035384)2.96278430
32acyl-CoA biosynthetic process (GO:0071616)2.96278430
33lipid particle organization (GO:0034389)2.94846130
34ethanol oxidation (GO:0006069)2.94256185
35positive regulation of fatty acid beta-oxidation (GO:0032000)2.93190679
36activation of protein kinase A activity (GO:0034199)2.89217220
37glutamate secretion (GO:0014047)2.86585419
38negative regulation of fibrinolysis (GO:0051918)2.86531438
39high-density lipoprotein particle remodeling (GO:0034375)2.84820419
40regulation of clathrin-mediated endocytosis (GO:2000369)2.83485014
41serine family amino acid metabolic process (GO:0009069)2.81591086
42aromatic amino acid family catabolic process (GO:0009074)2.81465520
43paraxial mesoderm development (GO:0048339)2.80862642
44bile acid biosynthetic process (GO:0006699)2.78180203
45white fat cell differentiation (GO:0050872)2.77976240
46regulation of RNA export from nucleus (GO:0046831)2.77266773
47regulation of triglyceride catabolic process (GO:0010896)2.77253149
48regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.76789037
49retina vasculature morphogenesis in camera-type eye (GO:0061299)2.75503308
50nucleobase catabolic process (GO:0046113)2.74687992
51positive regulation of lipid catabolic process (GO:0050996)2.73211798
52synaptic vesicle docking involved in exocytosis (GO:0016081)2.72864024
53negative regulation of fatty acid transport (GO:2000192)2.70720733
54regulation of nucleobase-containing compound transport (GO:0032239)2.70170500
55aspartate family amino acid catabolic process (GO:0009068)2.68939821
56fatty acid transmembrane transport (GO:1902001)2.67482359
57triglyceride homeostasis (GO:0070328)2.66329171
58acylglycerol homeostasis (GO:0055090)2.66329171
59long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.66291362
60fatty-acyl-CoA metabolic process (GO:0035337)2.65449532
61hippo signaling (GO:0035329)2.65307564
62locomotory exploration behavior (GO:0035641)2.64557001
63glycerolipid catabolic process (GO:0046503)2.64122439
64alpha-amino acid catabolic process (GO:1901606)2.63407171
65biotin metabolic process (GO:0006768)2.63249177
66acetyl-CoA metabolic process (GO:0006084)2.62884414
67urea metabolic process (GO:0019627)2.62843770
68urea cycle (GO:0000050)2.62843770
69complement activation, alternative pathway (GO:0006957)2.62758249
70anterior/posterior axis specification, embryo (GO:0008595)2.60052918
71glyoxylate metabolic process (GO:0046487)2.59679397
72regulation of protein activation cascade (GO:2000257)2.57867434
73proline transport (GO:0015824)2.57557889
74plasma lipoprotein particle clearance (GO:0034381)2.56630649
75response to methylmercury (GO:0051597)2.56424659
76coenzyme catabolic process (GO:0009109)2.55110588
77kynurenine metabolic process (GO:0070189)2.54605934
78macroautophagy (GO:0016236)2.54368664
79cellular ketone body metabolic process (GO:0046950)2.53341519
80triglyceride biosynthetic process (GO:0019432)2.52924229
81cellular amino acid catabolic process (GO:0009063)2.52850775
82reverse cholesterol transport (GO:0043691)2.52585753
83regulation of fibrinolysis (GO:0051917)2.52143498
84regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.51859656
85vocalization behavior (GO:0071625)2.50473804
86cellular modified amino acid catabolic process (GO:0042219)2.49882331
87cellular protein complex localization (GO:0034629)2.49785061
88NADH metabolic process (GO:0006734)2.49433920
89protein heterotrimerization (GO:0070208)2.49142459
90embryonic retina morphogenesis in camera-type eye (GO:0060059)2.48284589
91ectodermal placode formation (GO:0060788)2.46336305
92bile acid metabolic process (GO:0008206)2.44999120
93acylglycerol biosynthetic process (GO:0046463)2.44715656
94neutral lipid biosynthetic process (GO:0046460)2.44715656
95regulation of fatty acid beta-oxidation (GO:0031998)2.44584543
962-oxoglutarate metabolic process (GO:0006103)2.44053580
97protein targeting to Golgi (GO:0000042)2.43057317
98protein-lipid complex remodeling (GO:0034368)2.42894171
99macromolecular complex remodeling (GO:0034367)2.42894171
100plasma lipoprotein particle remodeling (GO:0034369)2.42894171
101neurotransmitter secretion (GO:0007269)2.41905557
102homocysteine metabolic process (GO:0050667)2.41804684
103regulation of complement activation (GO:0030449)2.41715334
104regulation of translational fidelity (GO:0006450)2.40487661
105dicarboxylic acid catabolic process (GO:0043649)2.40109127
106triglyceride metabolic process (GO:0006641)2.39299247
107low-density lipoprotein particle clearance (GO:0034383)2.38612386
108negative regulation of sodium ion transport (GO:0010766)2.38573379
109L-serine transport (GO:0015825)2.38303524
110regulation of cAMP-dependent protein kinase activity (GO:2000479)2.37717227
111positive regulation of glucose import (GO:0046326)2.36924372
112alanine transport (GO:0032328)2.36788870
113drug transmembrane transport (GO:0006855)2.36709392
114one-carbon metabolic process (GO:0006730)2.36561243
115negative regulation of sterol transport (GO:0032372)2.36279375
116negative regulation of cholesterol transport (GO:0032375)2.36279375
117negative regulation of norepinephrine secretion (GO:0010700)2.35126278
118positive regulation of fatty acid oxidation (GO:0046321)2.34322883
119endocrine hormone secretion (GO:0060986)2.33746018
120DNA unwinding involved in DNA replication (GO:0006268)2.33018020
121linoleic acid metabolic process (GO:0043651)2.32939267
122regulation of cholesterol homeostasis (GO:2000188)2.32429338
123valine metabolic process (GO:0006573)2.32348036
124negative regulation of macrophage differentiation (GO:0045650)2.27375872
125endothelial cell morphogenesis (GO:0001886)2.26394621
126L-serine metabolic process (GO:0006563)2.26253010
127notochord development (GO:0030903)2.25471246
128regulation of glycogen (starch) synthase activity (GO:2000465)2.25412841
129coenzyme A biosynthetic process (GO:0015937)2.21561141
130protein complex localization (GO:0031503)2.19311190
131protein localization to cell surface (GO:0034394)2.17208678
132regulation of glucose import in response to insulin stimulus (GO:2001273)2.16930782
133ER overload response (GO:0006983)2.16162181
134carnitine shuttle (GO:0006853)2.13249463
135negative regulation of DNA biosynthetic process (GO:2000279)2.12405743
136positive regulation of glucose transport (GO:0010828)2.10751709
137kidney mesenchyme development (GO:0072074)2.09699374
138maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.08807654
139acylglycerol metabolic process (GO:0006639)2.07529020
140adherens junction assembly (GO:0034333)2.06314732
141cellular response to vitamin (GO:0071295)2.06260762
142nuclear pore complex assembly (GO:0051292)2.05023291
143neutral lipid metabolic process (GO:0006638)2.03850360
144protein retention in ER lumen (GO:0006621)2.03402924
145response to dietary excess (GO:0002021)2.02740899
146focal adhesion assembly (GO:0048041)2.02549423
147cell-substrate adherens junction assembly (GO:0007045)2.02549423
148regulation of receptor biosynthetic process (GO:0010869)2.02428885
149mitotic sister chromatid cohesion (GO:0007064)2.00759771
150insulin-like growth factor receptor signaling pathway (GO:0048009)1.99267817
151positive regulation of macrophage activation (GO:0043032)1.99043194
152phosphatidic acid biosynthetic process (GO:0006654)1.96537567
153phosphatidic acid metabolic process (GO:0046473)1.96537567
154regulation of lipoprotein metabolic process (GO:0050746)1.95020548
155coenzyme A metabolic process (GO:0015936)1.94966915
156positive regulation of cellular response to insulin stimulus (GO:1900078)1.93842957
157tetrahydrofolate metabolic process (GO:0046653)1.93451873
158myelination in peripheral nervous system (GO:0022011)1.92782089
159peripheral nervous system axon ensheathment (GO:0032292)1.92782089
160cell-substrate junction assembly (GO:0007044)1.92505731
161non-canonical Wnt signaling pathway (GO:0035567)1.91998077
162mitotic chromosome condensation (GO:0007076)1.89845485
163thioester metabolic process (GO:0035383)1.89665781
164acyl-CoA metabolic process (GO:0006637)1.89665781
165regulation of gonadotropin secretion (GO:0032276)1.89419639
166collagen fibril organization (GO:0030199)1.89088952
167nuclear pore organization (GO:0006999)1.87786715
168chondrocyte development (GO:0002063)1.87595251
169NLS-bearing protein import into nucleus (GO:0006607)1.87051415
170positive regulation of cell cycle G2/M phase transition (GO:1902751)1.85653972
171positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)1.85653972
172muscle cell migration (GO:0014812)1.85365005
173convergent extension (GO:0060026)1.85016066
174positive regulation of glycolytic process (GO:0045821)1.84562003
175metanephric mesenchyme development (GO:0072075)1.83666757

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.83435295
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.72180982
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.44453932
4RXR_22158963_ChIP-Seq_LIVER_Mouse3.36546526
5FOXM1_23109430_ChIP-Seq_U2OS_Human2.80772009
6LXR_22158963_ChIP-Seq_LIVER_Mouse2.78895748
7PPARA_22158963_ChIP-Seq_LIVER_Mouse2.62413168
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.40994953
9NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.38162510
10TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.29982190
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.23039262
12ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.20429346
13TRIM28_21343339_ChIP-Seq_HEK293_Human2.16014161
14ZNF263_19887448_ChIP-Seq_K562_Human2.11271022
15SALL1_21062744_ChIP-ChIP_HESCs_Human2.09261257
16SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.03341691
17ESR1_15608294_ChIP-ChIP_MCF-7_Human1.98830573
18PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.97287640
19CLOCK_20551151_ChIP-Seq_293T_Human1.95541158
20FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.95271485
21RARB_27405468_Chip-Seq_BRAIN_Mouse1.95233249
22MYC_18555785_ChIP-Seq_MESCs_Mouse1.85134100
23RBPJ_22232070_ChIP-Seq_NCS_Mouse1.85055808
24ZNF274_21170338_ChIP-Seq_K562_Hela1.82942284
25EZH2_22144423_ChIP-Seq_EOC_Human1.74629705
26ZFP281_18757296_ChIP-ChIP_E14_Mouse1.63696936
27HIF1A_21447827_ChIP-Seq_MCF-7_Human1.60518164
28SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.59872389
29FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.56268547
30TP53_16413492_ChIP-PET_HCT116_Human1.54502406
31ERG_21242973_ChIP-ChIP_JURKAT_Human1.53849438
32WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.52372425
33REST_21632747_ChIP-Seq_MESCs_Mouse1.52136613
34* REST_18959480_ChIP-ChIP_MESCs_Mouse1.48643976
35ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.47416783
36AR_21572438_ChIP-Seq_LNCaP_Human1.47040325
37PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.39913913
38* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.39528468
39TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38453433
40DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.38136031
41RARG_19884340_ChIP-ChIP_MEFs_Mouse1.38043713
42KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.37509045
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.37078149
44FOXA2_19822575_ChIP-Seq_HepG2_Human1.36954782
45AR_21909140_ChIP-Seq_LNCAP_Human1.34581138
46GBX2_23144817_ChIP-Seq_PC3_Human1.32806291
47FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.32757290
48TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.32628027
49CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.32480302
50EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.32063744
51ZFX_18555785_ChIP-Seq_MESCs_Mouse1.32018573
52ESR2_21235772_ChIP-Seq_MCF-7_Human1.30291233
53P300_27058665_Chip-Seq_ZR-75-30cells_Human1.29577121
54PKCTHETA_26484144_Chip-Seq_BREAST_Human1.28928308
55KDM2B_26808549_Chip-Seq_K562_Human1.28474974
56WT1_19549856_ChIP-ChIP_CCG9911_Human1.26426344
57TP63_17297297_ChIP-ChIP_HaCaT_Human1.26188205
58E2F1_21310950_ChIP-Seq_MCF-7_Human1.25272253
59SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.24901798
60ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.23393725
61POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.23352456
62SOX2_21211035_ChIP-Seq_LN229_Gbm1.21296575
63HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.20126825
64MYCN_18555785_ChIP-Seq_MESCs_Mouse1.19470589
65SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.18714079
66ISL1_27105846_Chip-Seq_CPCs_Mouse1.16959272
67EED_16625203_ChIP-ChIP_MESCs_Mouse1.16311991
68SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.16083561
69ZFP281_27345836_Chip-Seq_ESCs_Mouse1.15845040
70TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.15222838
71KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.14594882
72TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.14229518
73NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.13731541
74NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.13275610
75WT1_25993318_ChIP-Seq_PODOCYTE_Human1.12601152
76OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11911660
77ESR1_21235772_ChIP-Seq_MCF-7_Human1.11485281
78NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.10643634
79STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.09635508
80ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09422828
81SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08695901
82TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.08330998
83KLF4_18555785_ChIP-Seq_MESCs_Mouse1.07982477
84SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.07417821
85CTBP2_25329375_ChIP-Seq_LNCAP_Human1.07366453
86SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.06570867
87RING1B_27294783_Chip-Seq_NPCs_Mouse1.06016569
88TBX3_20139965_ChIP-Seq_MESCs_Mouse1.05535924
89EGR1_23403033_ChIP-Seq_LIVER_Mouse1.04682762
90STAT3_23295773_ChIP-Seq_U87_Human1.04568942
91TBX3_20139965_ChIP-Seq_ESCs_Mouse1.04477419
92AR_19668381_ChIP-Seq_PC3_Human1.04116543
93MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.04030294
94CREB1_26743006_Chip-Seq_LNCaP_Human1.03944098
95AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.03299792
96* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.02757461
97* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.01520032
98MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.00600388
99GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.00023093
100RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.99589980
101NR3C1_23031785_ChIP-Seq_PC12_Mouse0.99522696
102MYC_19079543_ChIP-ChIP_MESCs_Mouse0.99007157
103* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.98592973
104BCAT_22108803_ChIP-Seq_LS180_Human0.98266483
105FOXO3_23340844_ChIP-Seq_DLD1_Human0.98118522
106PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.97577276
107CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.96728573
108RNF2_18974828_ChIP-Seq_MESCs_Mouse0.96600172
109EZH2_18974828_ChIP-Seq_MESCs_Mouse0.96600172
110* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.96133979
111EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.95776705
112GATA1_26923725_Chip-Seq_HPCs_Mouse0.95431707
113FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.95398055
114ARNT_22903824_ChIP-Seq_MCF-7_Human0.95334657
115MTF2_20144788_ChIP-Seq_MESCs_Mouse0.95328756
116* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.95185021
117PIAS1_25552417_ChIP-Seq_VCAP_Human0.93701034
118DROSHA_22980978_ChIP-Seq_HELA_Human0.93669168
119CHD1_26751641_Chip-Seq_LNCaP_Human0.93632553
120RXR_22108803_ChIP-Seq_LS180_Human0.93537872
121SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.93340799
122AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.92493157
123SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.92218482
124TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.92158429
125NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.91668681
126SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.90875166
127YAP1_20516196_ChIP-Seq_MESCs_Mouse0.90646713
128CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.90329955
129PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.89981913
130EZH2_27304074_Chip-Seq_ESCs_Mouse0.89832178
131HNF4A_19822575_ChIP-Seq_HepG2_Human0.89785982
132ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.89711262
133SOX2_27498859_Chip-Seq_STOMACH_Mouse0.89708838
134POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.89541986
135RACK7_27058665_Chip-Seq_MCF-7_Human0.89537067
136* MYC_19030024_ChIP-ChIP_MESCs_Mouse0.89239475
137NANOG_16518401_ChIP-PET_MESCs_Mouse0.89143866
138THAP11_20581084_ChIP-Seq_MESCs_Mouse0.88607463
139* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.88326136
140TET1_21490601_ChIP-Seq_MESCs_Mouse0.88281210
141SMAD4_21799915_ChIP-Seq_A2780_Human0.88246567
142CTNNB1_20460455_ChIP-Seq_HCT116_Human0.88153038
143PPAR_26484153_Chip-Seq_NCI-H1993_Human0.87456216
144GATA1_22025678_ChIP-Seq_K562_Human0.87434685
145BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.87393799
146RNF2_27304074_Chip-Seq_ESCs_Mouse0.87327086
147SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.86896566
148MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.85822141
149TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.85429098
150SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.85361746
151DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.84764506
152GATA4_21415370_ChIP-Seq_HL-1_Mouse0.84742068
153TP53_20018659_ChIP-ChIP_R1E_Mouse0.83253446
154REST_19997604_ChIP-ChIP_NEURONS_Mouse0.83102041
155TCF4_18268006_ChIP-ChIP_LS174T_Human0.82623471
156EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.82269581
157XRN2_22483619_ChIP-Seq_HELA_Human0.82084773
158E2F4_17652178_ChIP-ChIP_JURKAT_Human0.80451332
159* SOX17_20123909_ChIP-Seq_XEN_Mouse0.79607947
160NANOG_18555785_ChIP-Seq_MESCs_Mouse0.78914012
161UBF1/2_26484160_Chip-Seq_HMECs_Human0.78491988
162TCF3_18692474_ChIP-Seq_MEFs_Mouse0.77936445
163SOX9_26525672_Chip-Seq_HEART_Mouse0.77582675
164MYC_18358816_ChIP-ChIP_MESCs_Mouse0.77546354

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.94780542
2MP0005085_abnormal_gallbladder_physiolo3.59331462
3MP0004859_abnormal_synaptic_plasticity3.35555797
4MP0005360_urolithiasis3.26359245
5MP0008438_abnormal_cutaneous_collagen2.92963966
6MP0009780_abnormal_chondrocyte_physiolo2.75598767
7MP0005365_abnormal_bile_salt2.66570189
8MP0008875_abnormal_xenobiotic_pharmacok2.33272817
9MP0010329_abnormal_lipoprotein_level2.31617087
10MP0003123_paternal_imprinting2.30145312
11MP0004272_abnormal_basement_membrane2.25556527
12MP0004270_analgesia2.18235084
13MP0003252_abnormal_bile_duct2.08149588
14MP0004185_abnormal_adipocyte_glucose2.04585467
15MP0003635_abnormal_synaptic_transmissio2.01711953
16MP0003656_abnormal_erythrocyte_physiolo1.92065010
17MP0003705_abnormal_hypodermis_morpholog1.87841072
18MP0003329_amyloid_beta_deposits1.74341647
19MP0002063_abnormal_learning/memory/cond1.72146822
20MP0003806_abnormal_nucleotide_metabolis1.69721811
21MP0005666_abnormal_adipose_tissue1.66413915
22MP0004130_abnormal_muscle_cell1.59371421
23MP0002138_abnormal_hepatobiliary_system1.59059632
24MP0004885_abnormal_endolymph1.58455384
25MP0003890_abnormal_embryonic-extraembry1.57555104
26MP0000537_abnormal_urethra_morphology1.53486091
27MP0005275_abnormal_skin_tensile1.53352250
28MP0005083_abnormal_biliary_tract1.51432864
29MP0003942_abnormal_urinary_system1.51362777
30MP0006138_congestive_heart_failure1.49878817
31MP0005503_abnormal_tendon_morphology1.49058992
32MP0003950_abnormal_plasma_membrane1.48797136
33MP0003941_abnormal_skin_development1.45159166
34MP0003122_maternal_imprinting1.43965446
35MP0002118_abnormal_lipid_homeostasis1.40661738
36MP0005187_abnormal_penis_morphology1.38987155
37MP0005623_abnormal_meninges_morphology1.38148673
38MP0003868_abnormal_feces_composition1.36172824
39MP0003566_abnormal_cell_adhesion1.35909803
40MP0002877_abnormal_melanocyte_morpholog1.34323226
41MP0003880_abnormal_central_pattern1.33344631
42MP0002733_abnormal_thermal_nociception1.30929820
43MP0009115_abnormal_fat_cell1.30451657
44MP0000569_abnormal_digit_pigmentation1.29243281
45MP0000778_abnormal_nervous_system1.29170843
46MP0002064_seizures1.28257739
47MP0000566_synostosis1.27701362
48MP0002876_abnormal_thyroid_physiology1.27571588
49MP0010234_abnormal_vibrissa_follicle1.26149829
50MP0010352_gastrointestinal_tract_polyps1.26133998
51MP0002909_abnormal_adrenal_gland1.25829006
52MP0009745_abnormal_behavioral_response1.23445172
53MP0000762_abnormal_tongue_morphology1.22484335
54MP0000534_abnormal_ureter_morphology1.22165339
55MP0005375_adipose_tissue_phenotype1.21781587
56MP0001661_extended_life_span1.21560684
57MP0009672_abnormal_birth_weight1.21308088
58MP0002697_abnormal_eye_size1.18635147
59MP0002734_abnormal_mechanical_nocicepti1.17798446
60MP0004858_abnormal_nervous_system1.16548734
61MP0004811_abnormal_neuron_physiology1.15762682
62MP0002572_abnormal_emotion/affect_behav1.10809389
63MP0001666_abnormal_nutrient_absorption1.08056110
64MP0001486_abnormal_startle_reflex1.05128399
65MP0009053_abnormal_anal_canal1.05042169
66MP0009379_abnormal_foot_pigmentation1.04402209
67MP0002234_abnormal_pharynx_morphology1.03932241
68MP0010030_abnormal_orbit_morphology1.03616682
69MP0000609_abnormal_liver_physiology1.00614767
70MP0003283_abnormal_digestive_organ1.00310014
71MP0003690_abnormal_glial_cell0.99593215
72MP0005332_abnormal_amino_acid0.99502781
73MP0001968_abnormal_touch/_nociception0.99485510
74MP0009046_muscle_twitch0.98830692
75MP0005076_abnormal_cell_differentiation0.98594498
76MP0009384_cardiac_valve_regurgitation0.98355974
77MP0001881_abnormal_mammary_gland0.98050480
78MP0005409_darkened_coat_color0.97679970
79MP0000955_abnormal_spinal_cord0.96987115
80MP0002108_abnormal_muscle_morphology0.95749452
81MP0009840_abnormal_foam_cell0.95589084
82MP0003186_abnormal_redox_activity0.95432928
83MP0009703_decreased_birth_body0.95335527
84MP0005452_abnormal_adipose_tissue0.94613937
85MP0005257_abnormal_intraocular_pressure0.94548866
86MP0004147_increased_porphyrin_level0.94058145
87MP0000003_abnormal_adipose_tissue0.93717838
88MP0005535_abnormal_body_temperature0.93255271
89MP0003937_abnormal_limbs/digits/tail_de0.92873741
90MP0002272_abnormal_nervous_system0.91869042
91MP0008932_abnormal_embryonic_tissue0.91549811
92MP0000428_abnormal_craniofacial_morphol0.91194457
93MP0000604_amyloidosis0.91014601
94MP0009250_abnormal_appendicular_skeleto0.90433606
95MP0002971_abnormal_brown_adipose0.89548659
96MP0001440_abnormal_grooming_behavior0.89499892
97MP0000747_muscle_weakness0.89145331
98MP0005501_abnormal_skin_physiology0.88168089
99MP0004924_abnormal_behavior0.87568874
100MP0005386_behavior/neurological_phenoty0.87568874
101MP0002152_abnormal_brain_morphology0.87236708
102MP0001177_atelectasis0.84967394
103MP0003385_abnormal_body_wall0.84882209
104MP0004233_abnormal_muscle_weight0.84202016
105MP0003632_abnormal_nervous_system0.83552901
106MP0003195_calcinosis0.82842788
107MP0003633_abnormal_nervous_system0.82835254
108MP0004264_abnormal_extraembryonic_tissu0.82413221
109MP0001970_abnormal_pain_threshold0.82000049
110MP0002896_abnormal_bone_mineralization0.81843558
111MP0002066_abnormal_motor_capabilities/c0.81157441
112MP0004782_abnormal_surfactant_physiolog0.81147676
113MP0004957_abnormal_blastocyst_morpholog0.80859545
114MP0002078_abnormal_glucose_homeostasis0.80676874
115MP0003984_embryonic_growth_retardation0.80442788
116MP0004215_abnormal_myocardial_fiber0.80441452
117MP0002088_abnormal_embryonic_growth/wei0.79965098
118MP0000751_myopathy0.79872296
119MP0006276_abnormal_autonomic_nervous0.79721313
120MP0004084_abnormal_cardiac_muscle0.79361504
121MP0003755_abnormal_palate_morphology0.79253625
122MP0008775_abnormal_heart_ventricle0.78667042
123MP0005334_abnormal_fat_pad0.78178069
124MP0001879_abnormal_lymphatic_vessel0.78127534
125MP0003631_nervous_system_phenotype0.77329034
126MP0001672_abnormal_embryogenesis/_devel0.77209872
127MP0005380_embryogenesis_phenotype0.77209872
128MP0002060_abnormal_skin_morphology0.76937734
129MP0004043_abnormal_pH_regulation0.76890347
130MP0000013_abnormal_adipose_tissue0.76798154
131MP0003119_abnormal_digestive_system0.76030338
132MP0003935_abnormal_craniofacial_develop0.75859836
133MP0003315_abnormal_perineum_morphology0.75033325
134MP0001286_abnormal_eye_development0.73994712
135MP0000759_abnormal_skeletal_muscle0.73629043
136MP0002085_abnormal_embryonic_tissue0.73151287
137MP0004087_abnormal_muscle_fiber0.72740594
138MP0003693_abnormal_embryo_hatching0.72477336
139MP0001958_emphysema0.72423802
140MP0003861_abnormal_nervous_system0.72315742
141MP0003221_abnormal_cardiomyocyte_apopto0.72285579
142MP0002882_abnormal_neuron_morphology0.70898907
143MP0001188_hyperpigmentation0.70052435
144MP0003121_genomic_imprinting0.69778859
145MP0010678_abnormal_skin_adnexa0.69568705
146MP0002970_abnormal_white_adipose0.69044555
147MP0002067_abnormal_sensory_capabilities0.68390668
148MP0002084_abnormal_developmental_patter0.68287114
149MP0004197_abnormal_fetal_growth/weight/0.68021090
150MP0000049_abnormal_middle_ear0.67706711
151MP0000627_abnormal_mammary_gland0.67218860
152MP0002111_abnormal_tail_morphology0.66967434
153MP0010368_abnormal_lymphatic_system0.66946042
154MP0005584_abnormal_enzyme/coenzyme_acti0.66597915
155MP0002098_abnormal_vibrissa_morphology0.66253412
156MP0001697_abnormal_embryo_size0.65970518
157MP0002249_abnormal_larynx_morphology0.64802536
158MP0003959_abnormal_lean_body0.63977441
159MP0005670_abnormal_white_adipose0.63347944
160MP0002184_abnormal_innervation0.62251405
161MP0005448_abnormal_energy_balance0.62146417
162MP0002796_impaired_skin_barrier0.61718397
163MP0001299_abnormal_eye_distance/0.61659103
164MP0001730_embryonic_growth_arrest0.59404839
165MP0002069_abnormal_eating/drinking_beha0.59349493

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)4.19319538
2Termporal pattern (HP:0011008)3.99850212
3Insidious onset (HP:0003587)3.99850212
4Deep venous thrombosis (HP:0002625)3.61528910
5Protrusio acetabuli (HP:0003179)3.55312496
6Abnormality of the lower motor neuron (HP:0002366)3.24030593
7Hyperglycinemia (HP:0002154)3.19358654
8Cerebral inclusion bodies (HP:0100314)3.12634375
9Abnormality of monocarboxylic acid metabolism (HP:0010996)3.12608067
10Premature rupture of membranes (HP:0001788)3.10325858
11Xanthomatosis (HP:0000991)3.09118333
12Abnormal gallbladder physiology (HP:0012438)3.00716446
13Cholecystitis (HP:0001082)3.00716446
14Abnormality of the corticospinal tract (HP:0002492)2.87313490
15Missing ribs (HP:0000921)2.81869934
16Abnormality of the Achilles tendon (HP:0005109)2.80884515
17Hypobetalipoproteinemia (HP:0003563)2.80844382
18Hyperacusis (HP:0010780)2.80524667
19Hypochromic microcytic anemia (HP:0004840)2.77531387
20Impaired vibration sensation in the lower limbs (HP:0002166)2.75789301
21Abnormality of glycine metabolism (HP:0010895)2.74342326
22Abnormality of serine family amino acid metabolism (HP:0010894)2.74342326
23Coronal craniosynostosis (HP:0004440)2.74004484
24Ketosis (HP:0001946)2.71469479
25Back pain (HP:0003418)2.69233417
26Elfin facies (HP:0004428)2.66447962
27Neurofibrillary tangles (HP:0002185)2.65493663
28Epidermoid cyst (HP:0200040)2.64689269
29Spinal rigidity (HP:0003306)2.63488670
30Achilles tendon contracture (HP:0001771)2.61753967
31Macroorchidism (HP:0000053)2.59452813
32Abnormality of aromatic amino acid family metabolism (HP:0004338)2.59270642
3311 pairs of ribs (HP:0000878)2.55614852
34Morphological abnormality of the pyramidal tract (HP:0002062)2.48008696
35Renovascular hypertension (HP:0100817)2.47105421
36Focal seizures (HP:0007359)2.46651513
37Shallow orbits (HP:0000586)2.44605695
38Myokymia (HP:0002411)2.44497142
39Ketoacidosis (HP:0001993)2.43923281
40Ankle contracture (HP:0006466)2.43574083
41Bladder diverticulum (HP:0000015)2.42412351
42Overriding aorta (HP:0002623)2.41959740
43Hyperlipoproteinemia (HP:0010980)2.39108989
44Renal duplication (HP:0000075)2.38514111
45Hyperglycinuria (HP:0003108)2.38007474
46Abnormal social behavior (HP:0012433)2.37621354
47Impaired social interactions (HP:0000735)2.37621354
48Intention tremor (HP:0002080)2.37425851
49Focal motor seizures (HP:0011153)2.35315668
50Complement deficiency (HP:0004431)2.35054373
51Acanthosis nigricans (HP:0000956)2.34864407
52Action tremor (HP:0002345)2.32294830
53Urinary bladder sphincter dysfunction (HP:0002839)2.28500854
54Degeneration of the lateral corticospinal tracts (HP:0002314)2.27273710
55Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.27273710
56Flat cornea (HP:0007720)2.26742032
57Insomnia (HP:0100785)2.24773582
58Acanthocytosis (HP:0001927)2.24558723
59Megalocornea (HP:0000485)2.24496225
60Hypolipoproteinemia (HP:0010981)2.23144769
61Hyperammonemia (HP:0001987)2.22795335
62Urinary urgency (HP:0000012)2.19679069
63Global brain atrophy (HP:0002283)2.19557546
64Neoplasm of the peripheral nervous system (HP:0100007)2.17798486
65Abnormality of the astrocytes (HP:0100707)2.16928498
66Astrocytoma (HP:0009592)2.16928498
67Ulnar bowing (HP:0003031)2.15117437
68Spinal cord compression (HP:0002176)2.14063729
69Visual hallucinations (HP:0002367)2.11640528
70Resting tremor (HP:0002322)2.11414647
71Dysdiadochokinesis (HP:0002075)2.10677926
72Increased nuchal translucency (HP:0010880)2.08472818
73Supranuclear gaze palsy (HP:0000605)2.08299166
74Increased serum pyruvate (HP:0003542)2.07588611
75Hypoalphalipoproteinemia (HP:0003233)2.07186494
76Abnormality of glycolysis (HP:0004366)2.06871172
77Poor eye contact (HP:0000817)2.06713813
78Drooling (HP:0002307)2.05675766
79Excessive salivation (HP:0003781)2.05675766
80Spastic gait (HP:0002064)2.04306699
81Turricephaly (HP:0000262)2.03971058
82Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.03694899
83Oligomenorrhea (HP:0000876)2.03094831
84Pheochromocytoma (HP:0002666)2.02784813
85Abnormality of sulfur amino acid metabolism (HP:0004339)2.01985203
86Pseudobulbar signs (HP:0002200)2.00660203
87Impaired vibratory sensation (HP:0002495)2.00261902
88Abnormality of the common coagulation pathway (HP:0010990)1.99846451
89Spastic diplegia (HP:0001264)1.96736080
90Skin nodule (HP:0200036)1.96532245
91Hypsarrhythmia (HP:0002521)1.94099395
92Conjugated hyperbilirubinemia (HP:0002908)1.93394143
93Bowel diverticulosis (HP:0005222)1.93079758
94Hyperinsulinemic hypoglycemia (HP:0000825)1.91668266
95Generalized tonic-clonic seizures (HP:0002069)1.91518442
96Postural instability (HP:0002172)1.90204509
97Increased variability in muscle fiber diameter (HP:0003557)1.89746743
98Postural tremor (HP:0002174)1.89638849
99EEG with generalized epileptiform discharges (HP:0011198)1.89473009
100Cortical dysplasia (HP:0002539)1.89374180
101Absence seizures (HP:0002121)1.89078808
102Fibroma (HP:0010614)1.88986976
103Agitation (HP:0000713)1.88066173
104Abnormality of the intrinsic pathway (HP:0010989)1.87466706
105Epileptiform EEG discharges (HP:0011182)1.87344819
106Hyperthyroidism (HP:0000836)1.85432873
107Papilledema (HP:0001085)1.85217398
108Status epilepticus (HP:0002133)1.85166828
109Vertebral hypoplasia (HP:0008417)1.84978525
110Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.84978525
111Ankyloglossia (HP:0010296)1.82933463
112Hypercalcemia (HP:0003072)1.81482089
113Vascular tortuosity (HP:0004948)1.80796871
114Abnormality of the diencephalon (HP:0010662)1.80646623
115Fibrous tissue neoplasm (HP:0012316)1.79630983
116Hepatocellular carcinoma (HP:0001402)1.79533562
117Ependymoma (HP:0002888)1.79450651
118Rectal prolapse (HP:0002035)1.78465239
119Insulin resistance (HP:0000855)1.78200816
120Increased mean platelet volume (HP:0011877)1.78047912
121Epileptic encephalopathy (HP:0200134)1.76444798
122Clonus (HP:0002169)1.75386106
123Patellar dislocation (HP:0002999)1.75129750
124Broad metatarsal (HP:0001783)1.74268040
125Birth length less than 3rd percentile (HP:0003561)1.73114423
126Arterial tortuosity (HP:0005116)1.72998494
127Neuroendocrine neoplasm (HP:0100634)1.70931816
128Torticollis (HP:0000473)1.70682674
129Atonic seizures (HP:0010819)1.70025513
130Restlessness (HP:0000711)1.69498694
131Cholelithiasis (HP:0001081)1.69128391
132Depression (HP:0000716)1.68795478
133Enlarged penis (HP:0000040)1.68222355
134Dysmetric saccades (HP:0000641)1.67339085
135Hamartoma of the eye (HP:0010568)1.67216946
136Breech presentation (HP:0001623)1.66914163
137Dialeptic seizures (HP:0011146)1.66776476
138Microglossia (HP:0000171)1.66675214
139Lower limb muscle weakness (HP:0007340)1.66608211
140Prolonged partial thromboplastin time (HP:0003645)1.66333767
141Tetraplegia (HP:0002445)1.65787230
142Spastic paraplegia (HP:0001258)1.65678588
143Deviation of the hallux (HP:0010051)1.65579600
144Dysmetria (HP:0001310)1.65369402
145Spinal cord lesions (HP:0100561)1.64469538
146Syringomyelia (HP:0003396)1.64469538
147Wide anterior fontanel (HP:0000260)1.64407651
148Fragile skin (HP:0001030)1.63539999
149Abnormality of alanine metabolism (HP:0010916)1.63497275
150Hyperalaninemia (HP:0003348)1.63497275
151Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.63497275
152Arnold-Chiari malformation (HP:0002308)1.62267930
153Soft skin (HP:0000977)1.62259194
154Abnormality of carpal bone ossification (HP:0006257)1.60488273
155Follicular hyperkeratosis (HP:0007502)1.60235169
156Abnormality of skeletal muscle fiber size (HP:0012084)1.59026618
157Decreased subcutaneous fat (HP:0001002)1.58530498
158Large hands (HP:0001176)1.57807234
159Asymmetry of the thorax (HP:0001555)1.57766515
160Hallux valgus (HP:0001822)1.56947150
161Hypoplastic toenails (HP:0001800)1.56472162
162Cupped ribs (HP:0000887)1.55360843
163Mitral regurgitation (HP:0001653)1.54918700
164Abnormality of the phalanges of the hallux (HP:0010057)1.52560475
165Vertebral compression fractures (HP:0002953)1.51489430
166Rhizomelia (HP:0008905)1.50841691
167Long foot (HP:0001833)1.50039271
168Short nail (HP:0001799)1.49430390
169Breast hypoplasia (HP:0003187)1.48451267
170Septate vagina (HP:0001153)1.47072004
171High anterior hairline (HP:0009890)1.45735779
172Thin ribs (HP:0000883)1.45187130
173Wormian bones (HP:0002645)1.44280381
174Mitral valve prolapse (HP:0001634)1.43722969
175Aortic aneurysm (HP:0004942)1.43483804
176Progressive muscle weakness (HP:0003323)1.40991473
177Hyperextensible skin (HP:0000974)1.39501123
178Disproportionate tall stature (HP:0001519)1.39472297
179Ectopia lentis (HP:0001083)1.38993646
180Protruding ear (HP:0000411)1.38308332
181Abnormality of the gastric mucosa (HP:0004295)1.38043032
182Abnormality of the acetabulum (HP:0003170)1.37108585
183Abnormal ossification of hand bones (HP:0005921)1.36477134
184Advanced eruption of teeth (HP:0006288)1.36136897
185Renal tubular acidosis (HP:0001947)1.36097892
186Aortic dissection (HP:0002647)1.36012733
187Chromsome breakage (HP:0040012)1.32672088
188Delayed cranial suture closure (HP:0000270)1.32300042
189Abnormality of subcutaneous fat tissue (HP:0001001)1.31715803
190Short chin (HP:0000331)1.31055652
191Abnormality of the carotid arteries (HP:0005344)1.30946631

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK32.61452527
2NTRK32.58005905
3MAP3K92.53681161
4LATS22.35911334
5MARK12.30529794
6EIF2AK12.30026870
7MAP3K42.22553530
8EPHA42.22253303
9MAP2K42.13544528
10DAPK22.02098791
11PRKD32.01313372
12TRIB31.99908479
13MINK11.92304959
14TYRO31.87460281
15NTRK11.76598106
16PKN21.73143257
17SCYL21.62157144
18MAP3K21.59098627
19PTK21.50211478
20KSR21.48318946
21ALK1.46271927
22PAK61.43938972
23PLK21.38920089
24LATS11.38703478
25SIK11.38224908
26CDK61.35743721
27PNCK1.32916631
28RET1.31054844
29MET1.28652010
30EEF2K1.26584150
31PDK41.25768137
32PDK31.25768137
33DMPK1.24438806
34KSR11.24296397
35DDR21.21476752
36EPHA21.19921633
37NEK11.19693870
38TAOK11.17260465
39RPS6KB21.17251713
40MAP3K61.16432195
41WNK31.14792163
42STK241.12569598
43PAK21.11925422
44CLK11.11083653
45PDGFRA1.10560995
46WNK41.10324141
47FGFR21.10259709
48UHMK11.07241064
49MYLK1.07113738
50WEE11.05360543
51CSNK1G21.04208450
52CDK51.03804336
53DAPK11.03237038
54AKT31.02509060
55TSSK60.99512733
56WNK10.99363538
57NTRK20.99227471
58BUB10.99099110
59PTK60.98296344
60RIPK10.96398416
61BRAF0.95547198
62STK38L0.95462344
63CAMK1G0.94679099
64BCKDK0.92068170
65CDK120.90222036
66TTN0.90163027
67MAP2K70.89397832
68MATK0.89119207
69CDK140.88790335
70LMTK20.88360251
71MST1R0.86554981
72TTK0.86204067
73STK110.85746938
74FRK0.85660034
75MAPK130.84158717
76FGFR10.83327585
77LIMK10.82748407
78FER0.81594759
79PAK40.81229193
80MAPKAPK30.81139494
81CHEK20.80011340
82MTOR0.79724899
83CAMKK10.79576711
84CDK150.77514872
85PRKAA20.76436487
86GRK50.76047108
87NEK90.75643468
88CDK180.74996739
89CAMK1D0.71211891
90CDC70.70802322
91PAK30.70691117
92ICK0.70075381
93PINK10.68217313
94SIK20.68083796
95SGK30.67059935
96ILK0.66987740
97PDGFRB0.66772116
98PHKG10.66515829
99PHKG20.66515829
100TIE10.66214389
101MAP2K10.65864004
102IRAK30.65218012
103SMG10.64420420
104PBK0.63657398
105ARAF0.62508802
106CSNK1E0.62170936
107TRPM70.61944082
108AKT20.61859131
109PLK30.61802606
110CDK11A0.61723594
111CASK0.61643062
112CDK70.61621417
113CSNK1G30.61123859
114ERBB40.61074358
115AURKB0.59707300
116MAPKAPK50.59538114
117MAPK100.59100949
118TAF10.57982631
119MAPK120.57864499
120EPHB20.57830635
121CSNK1G10.57490968
122CAMK10.57180986
123CDK30.57077560
124STK390.56683691
125GSK3A0.56332477
126ABL20.56104964
127TESK10.55693978
128MAP3K70.55059345
129CDK190.54165170
130NEK20.52347394
131MARK20.52206812
132AURKA0.50572390
133CDK80.48531239
134PDK10.48477506
135PRKCG0.47714751
136RPS6KA20.47665868
137RPS6KB10.46874940
138PDPK10.46754226
139PLK10.46664039
140EIF2AK20.46565012
141PRKAA10.45955445
142STK160.45769614
143MKNK20.45578287
144MAP3K100.45381286
145BRSK20.45163642
146SGK2230.45043367
147SGK4940.45043367
148BMX0.44637610
149CDK40.44424604
150RPS6KA30.44071082

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.23200172
2Primary bile acid biosynthesis_Homo sapiens_hsa001202.55808066
3Arginine biosynthesis_Homo sapiens_hsa002202.39514076
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.34113429
5Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.24571564
6Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002502.07877197
7Butanoate metabolism_Homo sapiens_hsa006501.94755893
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.92079543
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.84973448
102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.77391651
11Propanoate metabolism_Homo sapiens_hsa006401.74367444
12Fatty acid degradation_Homo sapiens_hsa000711.73344143
13Fatty acid metabolism_Homo sapiens_hsa012121.72380258
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.72317534
15ECM-receptor interaction_Homo sapiens_hsa045121.66241143
16Fatty acid biosynthesis_Homo sapiens_hsa000611.58981213
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.54369405
18Bile secretion_Homo sapiens_hsa049761.53596189
19PPAR signaling pathway_Homo sapiens_hsa033201.51591719
20Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.48343677
21Tryptophan metabolism_Homo sapiens_hsa003801.40460824
22Sulfur relay system_Homo sapiens_hsa041221.37573303
23Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.36812817
24Pyruvate metabolism_Homo sapiens_hsa006201.33449425
25Long-term potentiation_Homo sapiens_hsa047201.18039735
26GABAergic synapse_Homo sapiens_hsa047271.13839134
27Complement and coagulation cascades_Homo sapiens_hsa046101.11551255
28Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.11256691
29Vitamin B6 metabolism_Homo sapiens_hsa007501.10640768
30Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.09836429
31Biosynthesis of amino acids_Homo sapiens_hsa012301.08397699
32Dopaminergic synapse_Homo sapiens_hsa047281.05096614
33Thyroid cancer_Homo sapiens_hsa052161.04989050
34Steroid biosynthesis_Homo sapiens_hsa001001.04917154
35Adherens junction_Homo sapiens_hsa045201.04061151
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.03644761
37Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.02585671
38Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.02381464
39Synaptic vesicle cycle_Homo sapiens_hsa047211.01220789
40Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.99614881
41Phenylalanine metabolism_Homo sapiens_hsa003600.98708417
42Carbon metabolism_Homo sapiens_hsa012000.98391468
43Sulfur metabolism_Homo sapiens_hsa009200.96888147
44Focal adhesion_Homo sapiens_hsa045100.94816528
45mTOR signaling pathway_Homo sapiens_hsa041500.94613238
46Fat digestion and absorption_Homo sapiens_hsa049750.94531463
47Amphetamine addiction_Homo sapiens_hsa050310.93063547
48Tyrosine metabolism_Homo sapiens_hsa003500.92777280
49Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.92114848
50beta-Alanine metabolism_Homo sapiens_hsa004100.91630896
51Dorso-ventral axis formation_Homo sapiens_hsa043200.91561095
52Dilated cardiomyopathy_Homo sapiens_hsa054140.89705000
53Nicotine addiction_Homo sapiens_hsa050330.88940856
54AMPK signaling pathway_Homo sapiens_hsa041520.88329076
55Glutamatergic synapse_Homo sapiens_hsa047240.87761610
56Melanoma_Homo sapiens_hsa052180.86931889
57Circadian entrainment_Homo sapiens_hsa047130.86513215
58Oocyte meiosis_Homo sapiens_hsa041140.85688773
59Insulin secretion_Homo sapiens_hsa049110.85107301
60Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.84719324
61Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.84101139
62Basal cell carcinoma_Homo sapiens_hsa052170.84018602
63Glycerolipid metabolism_Homo sapiens_hsa005610.83592041
64Glioma_Homo sapiens_hsa052140.83045230
65Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.82726757
66Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.82725508
67Glucagon signaling pathway_Homo sapiens_hsa049220.79654352
68Insulin signaling pathway_Homo sapiens_hsa049100.79526866
69Estrogen signaling pathway_Homo sapiens_hsa049150.78915779
70Fatty acid elongation_Homo sapiens_hsa000620.78558628
71Selenocompound metabolism_Homo sapiens_hsa004500.78322551
72Type II diabetes mellitus_Homo sapiens_hsa049300.77929001
73Cell cycle_Homo sapiens_hsa041100.76677357
74DNA replication_Homo sapiens_hsa030300.76345415
75Peroxisome_Homo sapiens_hsa041460.76114828
76Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.75741360
77Olfactory transduction_Homo sapiens_hsa047400.75640792
78Long-term depression_Homo sapiens_hsa047300.75061899
79Axon guidance_Homo sapiens_hsa043600.74739689
80Arginine and proline metabolism_Homo sapiens_hsa003300.74188001
81Morphine addiction_Homo sapiens_hsa050320.73051295
82Lysine degradation_Homo sapiens_hsa003100.72792335
83Renin secretion_Homo sapiens_hsa049240.72361384
84Gap junction_Homo sapiens_hsa045400.72190200
85Gastric acid secretion_Homo sapiens_hsa049710.72095408
86Aldosterone synthesis and secretion_Homo sapiens_hsa049250.72036885
87Mismatch repair_Homo sapiens_hsa034300.71563088
88Renal cell carcinoma_Homo sapiens_hsa052110.71387508
89ABC transporters_Homo sapiens_hsa020100.71277823
90Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.71256481
91Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.70495642
92Histidine metabolism_Homo sapiens_hsa003400.68413884
93Longevity regulating pathway - mammal_Homo sapiens_hsa042110.68139696
94Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.67929876
95Bladder cancer_Homo sapiens_hsa052190.67908318
96Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.67575277
97ErbB signaling pathway_Homo sapiens_hsa040120.67441145
98Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.67060400
99Salivary secretion_Homo sapiens_hsa049700.65228441
100Tight junction_Homo sapiens_hsa045300.65201006
101Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.64989796
102Starch and sucrose metabolism_Homo sapiens_hsa005000.64062886
103Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.63222519
104MicroRNAs in cancer_Homo sapiens_hsa052060.63103047
105Proteoglycans in cancer_Homo sapiens_hsa052050.63078798
106GnRH signaling pathway_Homo sapiens_hsa049120.62902676
107Cholinergic synapse_Homo sapiens_hsa047250.62242428
108Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.61076579
109Wnt signaling pathway_Homo sapiens_hsa043100.60831642
110Endometrial cancer_Homo sapiens_hsa052130.59171319
111Central carbon metabolism in cancer_Homo sapiens_hsa052300.59095736
112Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.58469211
113Insulin resistance_Homo sapiens_hsa049310.58416483
114Chronic myeloid leukemia_Homo sapiens_hsa052200.58348274
115TGF-beta signaling pathway_Homo sapiens_hsa043500.57548409
116mRNA surveillance pathway_Homo sapiens_hsa030150.57277716
117Thyroid hormone synthesis_Homo sapiens_hsa049180.57252628
118Hedgehog signaling pathway_Homo sapiens_hsa043400.57155995
119RNA transport_Homo sapiens_hsa030130.55177673
120Cocaine addiction_Homo sapiens_hsa050300.55085379
121Cyanoamino acid metabolism_Homo sapiens_hsa004600.53458425
122Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.52699069
123Small cell lung cancer_Homo sapiens_hsa052220.51774918
124Chemical carcinogenesis_Homo sapiens_hsa052040.51680172
125Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.50415356
126Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50395708
127Adipocytokine signaling pathway_Homo sapiens_hsa049200.50183591
128One carbon pool by folate_Homo sapiens_hsa006700.49921357
129Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49354251
130Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48821962
131Hippo signaling pathway_Homo sapiens_hsa043900.47590127
132Nucleotide excision repair_Homo sapiens_hsa034200.47206891
133Melanogenesis_Homo sapiens_hsa049160.47146632
134Regulation of actin cytoskeleton_Homo sapiens_hsa048100.45764517
135Glycerophospholipid metabolism_Homo sapiens_hsa005640.45588800
136cGMP-PKG signaling pathway_Homo sapiens_hsa040220.45535963
137Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45393461
138N-Glycan biosynthesis_Homo sapiens_hsa005100.44554470
139Folate biosynthesis_Homo sapiens_hsa007900.44321412
140Oxytocin signaling pathway_Homo sapiens_hsa049210.42090978
141Vascular smooth muscle contraction_Homo sapiens_hsa042700.41831759
142Non-small cell lung cancer_Homo sapiens_hsa052230.39887665

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