VLDLR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. This gene encodes a lipoprotein receptor that is a member of the LDLR family and plays important roles in VLDL-triglyceride metabolism and the reelin signaling pathway. Mutations in this gene cause VLDLR-associated cerebellar hypoplasia. Alternative splicing generates multiple transcript variants encoding distinct isoforms for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)4.34340403
2axon ensheathment in central nervous system (GO:0032291)4.34340403
3regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.82183346
4negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.79510701
5regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.68905121
6regulation of cell communication by electrical coupling (GO:0010649)3.62093530
7regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.61763197
8negative regulation of protein localization to cell surface (GO:2000009)3.58839165
9positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.56474908
10creatine metabolic process (GO:0006600)3.52541053
11sarcoplasmic reticulum calcium ion transport (GO:0070296)3.41443738
12negative regulation of potassium ion transmembrane transport (GO:1901380)3.39795024
13regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.36671975
14eye photoreceptor cell differentiation (GO:0001754)3.28960668
15photoreceptor cell differentiation (GO:0046530)3.28960668
16regulation of actin filament-based movement (GO:1903115)3.26524742
17regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.25925890
18cardiac myofibril assembly (GO:0055003)3.22695399
19cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.21894163
20myelination (GO:0042552)3.20400708
21ensheathment of neurons (GO:0007272)3.18797069
22axon ensheathment (GO:0008366)3.18797069
23sarcomere organization (GO:0045214)3.16422955
24regulation of relaxation of muscle (GO:1901077)3.15793677
25membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.14142555
26myofibril assembly (GO:0030239)3.10758246
27cellular response to epinephrine stimulus (GO:0071872)3.02380372
28potassium ion import (GO:0010107)3.00560140
29regulation of membrane repolarization (GO:0060306)2.99185702
30positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.96916210
31neuron cell-cell adhesion (GO:0007158)2.96029923
32establishment of mitochondrion localization (GO:0051654)2.92921291
33regulation of voltage-gated calcium channel activity (GO:1901385)2.91466340
34response to epinephrine (GO:0071871)2.91025344
35behavioral response to nicotine (GO:0035095)2.90300049
36regulation of calcium ion transmembrane transport (GO:1903169)2.89931216
37regulation of calcium ion transmembrane transporter activity (GO:1901019)2.89931216
38neuronal action potential propagation (GO:0019227)2.89859831
39regulation of cardiac muscle cell contraction (GO:0086004)2.89253640
40regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.86719874
41cell communication by electrical coupling (GO:0010644)2.83295985
42presynaptic membrane assembly (GO:0097105)2.82679634
43detection of calcium ion (GO:0005513)2.79413510
44synaptic vesicle maturation (GO:0016188)2.78822455
45regulation of skeletal muscle contraction (GO:0014819)2.78346638
46presynaptic membrane organization (GO:0097090)2.77317556
47regulation of acyl-CoA biosynthetic process (GO:0050812)2.76773196
48muscle filament sliding (GO:0030049)2.76540076
49actin-myosin filament sliding (GO:0033275)2.76540076
50cell communication involved in cardiac conduction (GO:0086065)2.75685749
51fatty acid elongation (GO:0030497)2.75642299
52positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.75473507
53adult heart development (GO:0007512)2.75013496
54cardiac muscle contraction (GO:0060048)2.74982251
55regulation of sequestering of triglyceride (GO:0010889)2.74937757
56positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.71204071
57kidney morphogenesis (GO:0060993)2.70474332
58positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.70096385
59locomotory exploration behavior (GO:0035641)2.69183468
60regulation of striated muscle contraction (GO:0006942)2.68248578
61positive regulation of potassium ion transport (GO:0043268)2.67940760
62positive regulation of action potential (GO:0045760)2.66123474
63regulation of glucokinase activity (GO:0033131)2.64867698
64regulation of hexokinase activity (GO:1903299)2.64867698
65membrane depolarization during action potential (GO:0086010)2.64836699
66regulation of short-term neuronal synaptic plasticity (GO:0048172)2.64275692
67regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.63345266
68regulation of mesoderm development (GO:2000380)2.62696362
69regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.62517807
70cardiac muscle cell action potential (GO:0086001)2.61946070
71regulation of action potential (GO:0098900)2.60844527
72actomyosin structure organization (GO:0031032)2.59963174
73vocalization behavior (GO:0071625)2.59930171
74regulation of cardiac muscle contraction (GO:0055117)2.59823718
75positive regulation of potassium ion transmembrane transport (GO:1901381)2.59741611
76ventricular cardiac muscle cell action potential (GO:0086005)2.57619958
77plasma membrane repair (GO:0001778)2.57619778
78cornea development in camera-type eye (GO:0061303)2.57432343
79cellular response to monoamine stimulus (GO:0071868)2.57234378
80cellular response to catecholamine stimulus (GO:0071870)2.57234378
81cardiac muscle hypertrophy (GO:0003300)2.56400947
82neuron recognition (GO:0008038)2.56103860
83negative regulation of hormone biosynthetic process (GO:0032353)2.55200332
84negative regulation of neurotransmitter secretion (GO:0046929)2.54891959
85response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.53340799
86negative regulation of neurotransmitter transport (GO:0051589)2.53157868
87protein localization to synapse (GO:0035418)2.52040884
88cardiac muscle cell action potential involved in contraction (GO:0086002)2.51374635
89positive regulation of glomerulus development (GO:0090193)2.50878486
90transmission of nerve impulse (GO:0019226)2.49379677
91adrenergic receptor signaling pathway (GO:0071875)2.48867346
92regulation of sarcomere organization (GO:0060297)2.48453591
93regulation of cofactor metabolic process (GO:0051193)2.48199444
94regulation of coenzyme metabolic process (GO:0051196)2.48199444
95cellular potassium ion homeostasis (GO:0030007)2.48173411
96positive regulation of heart rate (GO:0010460)2.47659320
97regulation of synapse structural plasticity (GO:0051823)2.47575686
98response to caffeine (GO:0031000)2.47332569
99regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.47151904
100striated muscle hypertrophy (GO:0014897)2.46559290
101nerve growth factor signaling pathway (GO:0038180)2.46463261
102synaptic vesicle exocytosis (GO:0016079)2.46399510
103regulation of potassium ion transmembrane transporter activity (GO:1901016)2.46306829
104adult walking behavior (GO:0007628)2.46287787
105cardiac conduction (GO:0061337)2.45450634
106neuromuscular junction development (GO:0007528)2.45347366
107positive regulation of glycolytic process (GO:0045821)2.44903222
108fatty acid transmembrane transport (GO:1902001)2.44289311
109regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.43907614
110regulation of potassium ion transmembrane transport (GO:1901379)2.43720318
111regulation of cation channel activity (GO:2001257)2.43334415
112response to monoamine (GO:0071867)2.43148739
113response to catecholamine (GO:0071869)2.43148739
114cerebellar granule cell differentiation (GO:0021707)2.42096224
115striated muscle contraction (GO:0006941)2.41825888
116carnitine shuttle (GO:0006853)2.41601077
117membrane tubulation (GO:0097320)2.41306817
118regulation of heart rate (GO:0002027)2.40372905
119ionotropic glutamate receptor signaling pathway (GO:0035235)2.39845644
120cardiac right ventricle morphogenesis (GO:0003215)2.39488913
121tricarboxylic acid cycle (GO:0006099)2.37937729
122somite development (GO:0061053)2.37194450
123regulation of type B pancreatic cell apoptotic process (GO:2000674)2.37120556
124dendrite morphogenesis (GO:0048813)2.36613701
125apical protein localization (GO:0045176)2.36566504
126positive regulation of cardiac muscle cell differentiation (GO:2000727)2.36521073
127actin-mediated cell contraction (GO:0070252)2.36458042
128regulation of rhodopsin mediated signaling pathway (GO:0022400)2.36447002
129negative regulation of cytosolic calcium ion concentration (GO:0051481)2.35963871
130dendritic spine morphogenesis (GO:0060997)2.35954060
131regulation of dendritic spine morphogenesis (GO:0061001)2.35948179
132regulation of the force of heart contraction (GO:0002026)2.35228675
133cardiac muscle cell development (GO:0055013)2.34843697
134positive regulation of sodium ion transport (GO:0010765)2.32218914
135regulation of heart rate by cardiac conduction (GO:0086091)2.31718351
136action potential (GO:0001508)2.31088855
137relaxation of cardiac muscle (GO:0055119)2.30982879
138calcium ion import (GO:0070509)2.29394840
139positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.25867080
140multicellular organismal signaling (GO:0035637)2.25498293
141cardiac muscle tissue morphogenesis (GO:0055008)2.23982150
142muscle fiber development (GO:0048747)2.23331357
143negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.22830666
144negative regulation of hormone metabolic process (GO:0032351)2.21810557
145adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.21586257
146cardiac cell development (GO:0055006)2.18607182
147lipid particle organization (GO:0034389)2.17957791
148regulation of acrosome reaction (GO:0060046)2.17718176
149otic vesicle formation (GO:0030916)2.17022213
150lateral sprouting from an epithelium (GO:0060601)2.16622207
151insulin secretion (GO:0030073)2.14863407
152regulation of gene silencing by RNA (GO:0060966)2.13421553
153regulation of posttranscriptional gene silencing (GO:0060147)2.13421553
154regulation of gene silencing by miRNA (GO:0060964)2.13421553
155cAMP catabolic process (GO:0006198)2.11764772
156regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.11120083
157response to inactivity (GO:0014854)2.10738429
158behavioral response to ethanol (GO:0048149)2.10299618
159neuronal action potential (GO:0019228)2.09545344
160cell migration involved in gastrulation (GO:0042074)2.08221177
161bundle of His cell to Purkinje myocyte communication (GO:0086069)2.07912190
162fatty acid homeostasis (GO:0055089)2.07847267
163positive regulation of cation channel activity (GO:2001259)2.07734829
164lung-associated mesenchyme development (GO:0060484)2.07635638
165muscle tissue morphogenesis (GO:0060415)2.04501933

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.97112354
2GBX2_23144817_ChIP-Seq_PC3_Human3.27325677
3* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.65058582
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.58889656
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.44374267
6RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.35883523
7* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.34518305
8* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.34518305
9* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.23302119
10* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.19820744
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.18271263
12DROSHA_22980978_ChIP-Seq_HELA_Human2.10281686
13* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.08255026
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.04834299
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.04609681
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.02413860
17* EP300_21415370_ChIP-Seq_HL-1_Mouse2.00285206
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.98102565
19EED_16625203_ChIP-ChIP_MESCs_Mouse1.97060346
20CDX2_19796622_ChIP-Seq_MESCs_Mouse1.95695334
21* EZH2_27294783_Chip-Seq_ESCs_Mouse1.93997409
22FLI1_27457419_Chip-Seq_LIVER_Mouse1.90176548
23AR_21572438_ChIP-Seq_LNCaP_Human1.86976707
24SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.84473057
25* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.80633355
26TAF15_26573619_Chip-Seq_HEK293_Human1.76616266
27* RNF2_27304074_Chip-Seq_ESCs_Mouse1.70989452
28PCGF2_27294783_Chip-Seq_ESCs_Mouse1.63869304
29* RARB_27405468_Chip-Seq_BRAIN_Mouse1.56216317
30MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.55600149
31* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.54456958
32* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.53207123
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49415083
34CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.49017459
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.45953187
36SUZ12_27294783_Chip-Seq_NPCs_Mouse1.45307438
37REST_21632747_ChIP-Seq_MESCs_Mouse1.42487029
38PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.42432483
39ZFP57_27257070_Chip-Seq_ESCs_Mouse1.42352662
40CTBP2_25329375_ChIP-Seq_LNCAP_Human1.42088507
41POU3F2_20337985_ChIP-ChIP_501MEL_Human1.41693772
42PIAS1_25552417_ChIP-Seq_VCAP_Human1.41333392
43SMAD4_21799915_ChIP-Seq_A2780_Human1.41116683
44PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.40064638
45* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.38536077
46SALL1_21062744_ChIP-ChIP_HESCs_Human1.36979516
47EWS_26573619_Chip-Seq_HEK293_Human1.34048323
48ESR1_20079471_ChIP-ChIP_T-47D_Human1.33852115
49NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.33221525
50NR3C1_23031785_ChIP-Seq_PC12_Mouse1.31951986
51* SMAD3_21741376_ChIP-Seq_EPCs_Human1.30533980
52IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.30441410
53CBP_20019798_ChIP-Seq_JUKART_Human1.30441410
54SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29506736
55RNF2_27304074_Chip-Seq_NSC_Mouse1.28529589
56ZNF274_21170338_ChIP-Seq_K562_Hela1.27399661
57PCGF2_27294783_Chip-Seq_NPCs_Mouse1.27361391
58EZH2_27294783_Chip-Seq_NPCs_Mouse1.27334417
59* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.27052770
60RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.26254496
61NFE2_27457419_Chip-Seq_LIVER_Mouse1.25907149
62CBX2_27304074_Chip-Seq_ESCs_Mouse1.25460036
63SOX2_21211035_ChIP-Seq_LN229_Gbm1.25425905
64ER_23166858_ChIP-Seq_MCF-7_Human1.24623750
65TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.23041786
66NANOG_18555785_Chip-Seq_ESCs_Mouse1.22877508
67REST_18959480_ChIP-ChIP_MESCs_Mouse1.21224534
68STAT3_23295773_ChIP-Seq_U87_Human1.20448138
69P300_19829295_ChIP-Seq_ESCs_Human1.20110590
70WT1_25993318_ChIP-Seq_PODOCYTE_Human1.18095525
71KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.16395148
72ZNF217_24962896_ChIP-Seq_MCF-7_Human1.16281568
73TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15984004
74POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.15984004
75VDR_22108803_ChIP-Seq_LS180_Human1.15640616
76TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14735414
77GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.13942615
78EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.13439151
79NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.12999891
80NRF2_20460467_ChIP-Seq_MEFs_Mouse1.12999891
81EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.12112168
82TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.11179354
83TCF4_22108803_ChIP-Seq_LS180_Human1.11011277
84SMAD4_21741376_ChIP-Seq_EPCs_Human1.09547195
85AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.09468844
86LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09019869
87TRIM28_21343339_ChIP-Seq_HEK293_Human1.08620047
88P53_22387025_ChIP-Seq_ESCs_Mouse1.08579387
89ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.08433872
90ARNT_22903824_ChIP-Seq_MCF-7_Human1.07497365
91KDM2B_26808549_Chip-Seq_REH_Human1.07012247
92FUS_26573619_Chip-Seq_HEK293_Human1.06624896
93BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.06026252
94EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.05836063
95NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05703087
96CJUN_26792858_Chip-Seq_BT549_Human1.05618407
97TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04941628
98TCF4_23295773_ChIP-Seq_U87_Human1.04836331
99CRX_20693478_ChIP-Seq_RETINA_Mouse1.04751333
100UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04693808
101AHR_22903824_ChIP-Seq_MCF-7_Human1.03700730
102VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.03449619
103RING1B_27294783_Chip-Seq_ESCs_Mouse1.03380008
104TP53_16413492_ChIP-PET_HCT116_Human1.03360339
105IGF1R_20145208_ChIP-Seq_DFB_Human1.03030682
106RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.03018460
107AR_19668381_ChIP-Seq_PC3_Human1.02634949
108CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.02463713
109TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01917538
110TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01318213
111TBX20_22328084_ChIP-Seq_HEART_Mouse0.99196457
112TBX20_22080862_ChIP-Seq_HEART_Mouse0.99196457
113* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.98919548
114ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.96128657
115AR_25329375_ChIP-Seq_VCAP_Human0.96069224
116P53_22127205_ChIP-Seq_FIBROBLAST_Human0.95580747
117PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.95158074
118MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95085539
119SMAD4_21741376_ChIP-Seq_HESCs_Human0.94909130
120WT1_19549856_ChIP-ChIP_CCG9911_Human0.93947430
121BCAT_22108803_ChIP-Seq_LS180_Human0.93823218
122TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.93611617
123TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.92886189
124* SMAD3_21741376_ChIP-Seq_HESCs_Human0.92844304
125CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.90879035
126YAP1_20516196_ChIP-Seq_MESCs_Mouse0.90705534
127CTNNB1_20460455_ChIP-Seq_HCT116_Human0.90281729
128PRDM14_20953172_ChIP-Seq_ESCs_Human0.90149077
129MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.90084046
130RUNX2_22187159_ChIP-Seq_PCA_Human0.87683568
131BMI1_23680149_ChIP-Seq_NPCS_Mouse0.86392672
132ERG_21242973_ChIP-ChIP_JURKAT_Human0.85534141

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis3.93537477
2MP0000751_myopathy3.40882126
3MP0004084_abnormal_cardiac_muscle2.85878242
4MP0004036_abnormal_muscle_relaxation2.83271389
5MP0003880_abnormal_central_pattern2.82827329
6MP0003283_abnormal_digestive_organ2.82302632
7MP0004215_abnormal_myocardial_fiber2.76556626
8MP0004145_abnormal_muscle_electrophysio2.72109896
9MP0003646_muscle_fatigue2.65595152
10MP0004270_analgesia2.55758011
11* MP0004859_abnormal_synaptic_plasticity2.51503672
12MP0002876_abnormal_thyroid_physiology2.41624674
13MP0000749_muscle_degeneration2.39535340
14MP0003950_abnormal_plasma_membrane2.27002241
15MP0005551_abnormal_eye_electrophysiolog2.18405691
16MP0004130_abnormal_muscle_cell2.15832833
17MP0000920_abnormal_myelination2.14941942
18MP0005330_cardiomyopathy2.14896950
19* MP0003635_abnormal_synaptic_transmissio2.08160379
20MP0003137_abnormal_impulse_conducting1.97267774
21MP0005620_abnormal_muscle_contractility1.88711251
22MP0002272_abnormal_nervous_system1.88065557
23MP0002064_seizures1.83084260
24MP0003195_calcinosis1.81417212
25MP0000747_muscle_weakness1.79375324
26MP0004087_abnormal_muscle_fiber1.78220979
27MP0002638_abnormal_pupillary_reflex1.77708809
28MP0009745_abnormal_behavioral_response1.76707537
29MP0009046_muscle_twitch1.76586763
30MP0004484_altered_response_of1.75272101
31MP0001486_abnormal_startle_reflex1.74123023
32MP0002972_abnormal_cardiac_muscle1.71931447
33MP0005646_abnormal_pituitary_gland1.68979829
34MP0004085_abnormal_heartbeat1.62800200
35MP0003329_amyloid_beta_deposits1.61072011
36MP0008775_abnormal_heart_ventricle1.60296883
37MP0001984_abnormal_olfaction1.57359659
38MP0002106_abnormal_muscle_physiology1.56509182
39MP0005423_abnormal_somatic_nervous1.55916853
40MP0002102_abnormal_ear_morphology1.54546877
41* MP0002063_abnormal_learning/memory/cond1.53071298
42MP0009780_abnormal_chondrocyte_physiolo1.49439642
43MP0003787_abnormal_imprinting1.48826529
44MP0008877_abnormal_DNA_methylation1.47986095
45MP0004043_abnormal_pH_regulation1.47779528
46MP0004885_abnormal_endolymph1.45560101
47MP0003690_abnormal_glial_cell1.44696667
48MP0000759_abnormal_skeletal_muscle1.44340280
49MP0008569_lethality_at_weaning1.44063300
50MP0005369_muscle_phenotype1.43163834
51MP0000013_abnormal_adipose_tissue1.42368248
52MP0006072_abnormal_retinal_apoptosis1.41931014
53MP0006276_abnormal_autonomic_nervous1.40259410
54MP0002734_abnormal_mechanical_nocicepti1.40006937
55MP0006138_congestive_heart_failure1.33469405
56MP0002572_abnormal_emotion/affect_behav1.33030689
57MP0000778_abnormal_nervous_system1.32380391
58MP0005253_abnormal_eye_physiology1.31534903
59MP0000372_irregular_coat_pigmentation1.30571038
60MP0004924_abnormal_behavior1.29139646
61MP0005386_behavior/neurological_phenoty1.29139646
62MP0005666_abnormal_adipose_tissue1.28395045
63MP0002909_abnormal_adrenal_gland1.25515818
64MP0001440_abnormal_grooming_behavior1.25287049
65MP0002067_abnormal_sensory_capabilities1.24808573
66* MP0002229_neurodegeneration1.24797883
67MP0003634_abnormal_glial_cell1.23390220
68MP0003011_delayed_dark_adaptation1.22799732
69MP0002269_muscular_atrophy1.22798916
70MP0005385_cardiovascular_system_phenoty1.21321264
71MP0001544_abnormal_cardiovascular_syste1.21321264
72MP0001529_abnormal_vocalization1.20878778
73MP0003122_maternal_imprinting1.19135572
74MP0004142_abnormal_muscle_tone1.17790117
75MP0004233_abnormal_muscle_weight1.16594007
76MP0002938_white_spotting1.16436469
77MP0004185_abnormal_adipocyte_glucose1.15791898
78MP0002108_abnormal_muscle_morphology1.15452158
79MP0005503_abnormal_tendon_morphology1.13520212
80MP0001299_abnormal_eye_distance/1.12281561
81MP0005375_adipose_tissue_phenotype1.12098153
82MP0003119_abnormal_digestive_system1.11269852
83MP0002127_abnormal_cardiovascular_syste1.10317850
84MP0004742_abnormal_vestibular_system1.10192248
85MP0004133_heterotaxia1.08889297
86* MP0002882_abnormal_neuron_morphology1.07798951
87MP0002090_abnormal_vision1.07787546
88MP0008438_abnormal_cutaneous_collagen1.05951598
89MP0003937_abnormal_limbs/digits/tail_de1.05709210
90MP0010630_abnormal_cardiac_muscle1.04371028
91MP0000003_abnormal_adipose_tissue1.03848525
92MP0000631_abnormal_neuroendocrine_gland1.03219003
93MP0003136_yellow_coat_color1.02478758
94MP0000750_abnormal_muscle_regeneration1.02189112
95MP0005379_endocrine/exocrine_gland_phen1.01816519
96MP0002822_catalepsy1.01508823
97MP0002234_abnormal_pharynx_morphology0.98807727
98MP0005645_abnormal_hypothalamus_physiol0.98010510
99* MP0002066_abnormal_motor_capabilities/c0.97137795
100MP0005171_absent_coat_pigmentation0.96752519
101MP0001968_abnormal_touch/_nociception0.95884187
102MP0005623_abnormal_meninges_morphology0.93982092
103MP0000955_abnormal_spinal_cord0.93705137
104MP0001905_abnormal_dopamine_level0.92633747
105MP0001502_abnormal_circadian_rhythm0.92213517
106MP0002735_abnormal_chemical_nociception0.92169799
107MP0001501_abnormal_sleep_pattern0.91170014
108MP0000569_abnormal_digit_pigmentation0.90984385
109MP0001970_abnormal_pain_threshold0.90841461
110MP0001944_abnormal_pancreas_morphology0.89741080
111MP0001485_abnormal_pinna_reflex0.89431124
112MP0003633_abnormal_nervous_system0.88803555
113MP0002184_abnormal_innervation0.88511033
114MP0002557_abnormal_social/conspecific_i0.88396824
115MP0001661_extended_life_span0.88001598
116MP0003890_abnormal_embryonic-extraembry0.86817082
117MP0005409_darkened_coat_color0.85761557
118MP0002254_reproductive_system_inflammat0.85578418
119* MP0002752_abnormal_somatic_nervous0.84964528
120MP0003632_abnormal_nervous_system0.82664959
121MP0004147_increased_porphyrin_level0.81924305
122MP0003631_nervous_system_phenotype0.81620117
123* MP0005195_abnormal_posterior_eye0.81187019
124MP0000230_abnormal_systemic_arterial0.80095712
125MP0002971_abnormal_brown_adipose0.78205800
126MP0000462_abnormal_digestive_system0.78056807
127MP0003121_genomic_imprinting0.77497658
128MP0002733_abnormal_thermal_nociception0.77449881
129MP0002736_abnormal_nociception_after0.76651863
130MP0005535_abnormal_body_temperature0.76602686
131MP0000049_abnormal_middle_ear0.76499159
132MP0004272_abnormal_basement_membrane0.76308662
133MP0005187_abnormal_penis_morphology0.76247198
134MP0005670_abnormal_white_adipose0.75861168
135MP0009384_cardiac_valve_regurgitation0.75463466
136MP0004510_myositis0.75204084
137MP0002163_abnormal_gland_morphology0.74482945
138MP0010386_abnormal_urinary_bladder0.73833042

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)4.53413480
2Muscle hypertrophy of the lower extremities (HP:0008968)4.47384226
3Sudden death (HP:0001699)4.46309460
4Calf muscle hypertrophy (HP:0008981)4.31006756
5Muscle fiber splitting (HP:0003555)4.05463349
6Exercise-induced muscle cramps (HP:0003710)3.70543558
7Abnormality of the calf musculature (HP:0001430)3.70308102
8Hyporeflexia of lower limbs (HP:0002600)3.66363043
9Atrial fibrillation (HP:0005110)3.60918929
10Central scotoma (HP:0000603)3.47241930
11Prolonged QT interval (HP:0001657)3.42216528
12Primary atrial arrhythmia (HP:0001692)3.37668895
13Difficulty running (HP:0009046)3.35658338
14Syncope (HP:0001279)3.34631139
15Focal motor seizures (HP:0011153)3.23903739
16Neurofibrillary tangles (HP:0002185)3.18447761
17Supraventricular tachycardia (HP:0004755)3.17698920
18Supraventricular arrhythmia (HP:0005115)3.11084359
19Myoglobinuria (HP:0002913)3.05195722
20Degeneration of the lateral corticospinal tracts (HP:0002314)3.01336344
21Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.01336344
22EMG: myopathic abnormalities (HP:0003458)2.91737262
23Ventricular tachycardia (HP:0004756)2.83009797
24Pheochromocytoma (HP:0002666)2.81444461
25Congenital stationary night blindness (HP:0007642)2.76717175
26Thyroid-stimulating hormone excess (HP:0002925)2.71067871
27Scotoma (HP:0000575)2.63223411
28Rimmed vacuoles (HP:0003805)2.60362524
29Increased variability in muscle fiber diameter (HP:0003557)2.58002194
30Renal cortical cysts (HP:0000803)2.56317529
31Myokymia (HP:0002411)2.56176294
32Hyperinsulinemic hypoglycemia (HP:0000825)2.53599987
33Cerebral inclusion bodies (HP:0100314)2.51739228
34Myotonia (HP:0002486)2.51406682
35Muscle fiber inclusion bodies (HP:0100299)2.49886402
36Hyperglycemia (HP:0003074)2.49524428
37Abnormality of the corticospinal tract (HP:0002492)2.47640370
38Abnormal EKG (HP:0003115)2.46796623
39Insulin-resistant diabetes mellitus (HP:0000831)2.46222406
40Large for gestational age (HP:0001520)2.45806106
41Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.43904938
42Lipoatrophy (HP:0100578)2.43415365
43Ventricular fibrillation (HP:0001663)2.41344426
44Abnormality of macular pigmentation (HP:0008002)2.40984826
45Intestinal atresia (HP:0011100)2.39905173
46Neuroendocrine neoplasm (HP:0100634)2.38244011
47Bundle branch block (HP:0011710)2.37321173
48Hypoglycemic seizures (HP:0002173)2.37052131
49Abnormality of the renal cortex (HP:0011035)2.36325355
50Nephronophthisis (HP:0000090)2.35200573
51Dilated cardiomyopathy (HP:0001644)2.34245015
52Type II lissencephaly (HP:0007260)2.33420452
53Supranuclear gaze palsy (HP:0000605)2.33158383
54Ventricular arrhythmia (HP:0004308)2.33026500
55Hemiparesis (HP:0001269)2.31747296
56Hypoglycemic coma (HP:0001325)2.30477666
57Type 1 muscle fiber predominance (HP:0003803)2.30244638
58Focal seizures (HP:0007359)2.29526151
59Febrile seizures (HP:0002373)2.28447273
60Epileptic encephalopathy (HP:0200134)2.28180798
61Subaortic stenosis (HP:0001682)2.24421142
62Abnormality of the left ventricular outflow tract (HP:0011103)2.24421142
63Gowers sign (HP:0003391)2.23806974
64* Dysmetria (HP:0001310)2.22896514
65Action tremor (HP:0002345)2.20599213
66Hypoplastic ischia (HP:0003175)2.20403038
67Short hallux (HP:0010109)2.17527996
68Aplasia/Hypoplasia of the hallux (HP:0008362)2.13983450
69Termporal pattern (HP:0011008)2.13941013
70Insidious onset (HP:0003587)2.13941013
71Oligomenorrhea (HP:0000876)2.13422534
72Abnormality of skeletal muscle fiber size (HP:0012084)2.13135932
73Hyperventilation (HP:0002883)2.11171646
74Nemaline bodies (HP:0003798)2.10944651
75Right ventricular cardiomyopathy (HP:0011663)2.09608893
76Broad metatarsal (HP:0001783)2.08557412
77Atonic seizures (HP:0010819)2.07477525
78Optic nerve hypoplasia (HP:0000609)2.07404099
79Scapular winging (HP:0003691)2.06148119
80Muscle stiffness (HP:0003552)2.05630357
81Scanning speech (HP:0002168)2.04468816
82Abnormality of the renal medulla (HP:0100957)2.04133686
83Ankle clonus (HP:0011448)2.01816748
84Spastic gait (HP:0002064)2.00963587
85Neck muscle weakness (HP:0000467)2.00496926
86Left ventricular hypertrophy (HP:0001712)2.00326935
87Agitation (HP:0000713)2.00149010
88Visual hallucinations (HP:0002367)1.99715722
89Progressive inability to walk (HP:0002505)1.98852478
90Abnormality of endocrine pancreas physiology (HP:0012093)1.97584068
91Abnormality of the pancreatic islet cells (HP:0006476)1.97584068
92Onion bulb formation (HP:0003383)1.97115534
93Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.96583627
94Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.95919321
95Foot dorsiflexor weakness (HP:0009027)1.94670771
96Distal arthrogryposis (HP:0005684)1.93972463
97Abnormality of the ischium (HP:0003174)1.93449597
98Molar tooth sign on MRI (HP:0002419)1.92804641
99Abnormality of midbrain morphology (HP:0002418)1.92804641
100Retinal dysplasia (HP:0007973)1.92702164
101Bony spicule pigmentary retinopathy (HP:0007737)1.91462668
102Pancreatic islet-cell hyperplasia (HP:0004510)1.91345483
103Abnormality of glycolysis (HP:0004366)1.90889308
104Increased serum pyruvate (HP:0003542)1.90889308
105Maternal diabetes (HP:0009800)1.89577244
106Acute necrotizing encephalopathy (HP:0006965)1.89243323
107Pancreatic cysts (HP:0001737)1.88738258
108Increased corneal curvature (HP:0100692)1.88027977
109Keratoconus (HP:0000563)1.88027977
110Pancreatic fibrosis (HP:0100732)1.87264722
111* Gaze-evoked nystagmus (HP:0000640)1.86749297
112Late onset (HP:0003584)1.86331059
113* Intention tremor (HP:0002080)1.86259537
114Morphological abnormality of the middle ear (HP:0008609)1.85111550
115Abnormal mitochondria in muscle tissue (HP:0008316)1.84876394
116Ketoacidosis (HP:0001993)1.84527559
117Abnormality of the foot musculature (HP:0001436)1.84431587
118Heart block (HP:0012722)1.84340106
119Generalized tonic-clonic seizures (HP:0002069)1.83497804
120* Broad-based gait (HP:0002136)1.83198161
121Chorioretinal atrophy (HP:0000533)1.82315159
122Absent phalangeal crease (HP:0006109)1.82232440
123Anxiety (HP:0000739)1.82007962
124Genetic anticipation (HP:0003743)1.81577478
125Peripheral hypomyelination (HP:0007182)1.80907034
126Dyschromatopsia (HP:0007641)1.80877153
127Abnormal pancreas size (HP:0012094)1.80858246
128Cerebral hemorrhage (HP:0001342)1.79770062
129Lower limb muscle weakness (HP:0007340)1.79360701
130Rhabdomyolysis (HP:0003201)1.79035746
131* Dysdiadochokinesis (HP:0002075)1.78425681
132Frequent falls (HP:0002359)1.77274427
133Ketosis (HP:0001946)1.76843028
134Abolished electroretinogram (ERG) (HP:0000550)1.76611117
135Cerebellar dysplasia (HP:0007033)1.76513889
136Palpitations (HP:0001962)1.76005723
137Asymmetric septal hypertrophy (HP:0001670)1.75098623
138Anterior segment dysgenesis (HP:0007700)1.73997426
139Inability to walk (HP:0002540)1.73924847
140Progressive macrocephaly (HP:0004481)1.72675338
141Dialeptic seizures (HP:0011146)1.72499102
142Methylmalonic acidemia (HP:0002912)1.71083956
143Poor eye contact (HP:0000817)1.70401298
144Aplasia/Hypoplasia of the fovea (HP:0008060)1.68189065
145Hypoplasia of the fovea (HP:0007750)1.68189065
146Progressive cerebellar ataxia (HP:0002073)1.66979113
147True hermaphroditism (HP:0010459)1.66844551
148Optic disc pallor (HP:0000543)1.66179390
149Abnormal atrioventricular conduction (HP:0005150)1.65400377
150Absence seizures (HP:0002121)1.64969096
151Areflexia of lower limbs (HP:0002522)1.64476967
152Proximal amyotrophy (HP:0007126)1.63198848
153Cutaneous finger syndactyly (HP:0010554)1.62267808

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.40120762
2STK394.11569412
3PHKG23.09162824
4PHKG13.09162824
5BMPR1B2.75770355
6OBSCN2.66943517
7OXSR12.58135236
8WNK42.42852715
9TNIK2.36213286
10TTN2.22618739
11ADRBK22.20536107
12EPHA42.16418817
13MARK12.07461500
14WNK31.93219301
15STK38L1.91299702
16PRPF4B1.77662999
17NTRK31.76817051
18WNK11.76006022
19MUSK1.74290377
20MAP4K21.67066913
21PKN11.64882742
22EPHB11.61753252
23CAMK2D1.58842623
24DMPK1.55622955
25PINK11.54018247
26PIK3CA1.53407479
27PDK41.48814184
28PDK31.48814184
29FGFR21.46437469
30MAP3K41.46053967
31PAK31.39701768
32PAK61.39523105
33LMTK21.38895178
34BCR1.37904867
35MYLK1.36238588
36NTRK11.36001374
37CASK1.29318478
38UHMK11.23674914
39ZAK1.20236318
40CAMK2B1.15250979
41TAOK31.15245371
42INSRR1.15007605
43CAMK2A1.14397705
44MAP3K91.13350147
45ICK1.13279916
46TLK11.09102682
47ROCK21.08916565
48PLK21.05444664
49CDK51.04325611
50SGK4941.04130174
51SGK2231.04130174
52PRKD11.01913013
53FLT31.01100423
54TYRO31.00579826
55MET0.99406590
56MAPKAPK50.98273400
57TGFBR10.93482654
58CDK190.93110025
59PDK20.90810988
60PNCK0.90525644
61MAPKAPK30.89716558
62MAP2K70.89444687
63PRKCG0.89164519
64PRKCE0.88540958
65NUAK10.88215478
66CAMK1G0.87769249
67MAP2K40.87639222
68KSR20.86374265
69CAMK2G0.85681242
70LATS10.85563383
71PRKD30.85039275
72NTRK20.83528389
73MARK20.83119576
74MINK10.83024940
75ERBB30.82937960
76MAP3K70.82547573
77ACVR1B0.82260046
78MAPK120.81532407
79PDPK10.81521508
80NLK0.80268537
81ADRBK10.80048942
82RET0.78624273
83CAMK10.78296116
84NEK60.78193579
85STK30.75061853
86CAMKK20.74201573
87CSNK1G20.73048225
88MAPK130.72999187
89CAMK1D0.72425145
90PRKCH0.70178368
91NME10.67477557
92STK110.65458866
93MAP2K10.65340321
94BCKDK0.65305390
95LIMK10.63318606
96ROCK10.63300573
97KSR10.62597942
98CSNK1A1L0.62277804
99GRK70.62182844
100FGR0.60228432
101PTK2B0.60164362
102SGK20.60006610
103CSNK1G30.59803127
104DYRK20.59281560
105TIE10.58465121
106PDK10.57724670
107DDR20.57446116
108PDGFRB0.56763544
109PRKAA20.56323742
110PDGFRA0.56153279
111MKNK20.55475000
112SGK10.53656930
113MAP2K20.53143407
114PRKG10.52679888
115EPHA30.52657462
116PRKACA0.51861626
117FES0.50786828
118PRKACB0.50756857
119CAMKK10.50686073
120CDC42BPA0.50498744
121FER0.49931340
122TRPM70.49831189
123CSNK1G10.49237599
124PRKAA10.47479476
125CDK140.46949289
126GRK10.46597437
127CSNK1D0.45995386
128STK240.45807825
129DAPK20.45700895
130EPHB20.40077796
131RPS6KA30.39634818
132PASK0.37222609
133GRK50.34752817
134STK380.33626018
135CDK80.33265404
136MST40.32348871
137PRKACG0.32051748

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047442.72133639
2Maturity onset diabetes of the young_Homo sapiens_hsa049502.53153325
3Cardiac muscle contraction_Homo sapiens_hsa042602.28589456
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.21357969
5Fatty acid elongation_Homo sapiens_hsa000622.13187021
6Dilated cardiomyopathy_Homo sapiens_hsa054142.11969183
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.94932562
8GABAergic synapse_Homo sapiens_hsa047271.94716303
9Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.87451313
10Propanoate metabolism_Homo sapiens_hsa006401.85359679
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.82883895
12Circadian entrainment_Homo sapiens_hsa047131.81536551
13Nicotine addiction_Homo sapiens_hsa050331.79174533
14Glutamatergic synapse_Homo sapiens_hsa047241.78452563
15Morphine addiction_Homo sapiens_hsa050321.72432645
16Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.61992053
17Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.61127859
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.58460913
19Oxidative phosphorylation_Homo sapiens_hsa001901.57877713
20Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.49725389
21Butanoate metabolism_Homo sapiens_hsa006501.45725754
22Olfactory transduction_Homo sapiens_hsa047401.43083025
23Salivary secretion_Homo sapiens_hsa049701.42672666
24Renin secretion_Homo sapiens_hsa049241.42059830
25Fatty acid metabolism_Homo sapiens_hsa012121.40424885
26Gastric acid secretion_Homo sapiens_hsa049711.40215467
27Tryptophan metabolism_Homo sapiens_hsa003801.37661231
28Alzheimers disease_Homo sapiens_hsa050101.37151387
29Parkinsons disease_Homo sapiens_hsa050121.35341027
30Synaptic vesicle cycle_Homo sapiens_hsa047211.35205680
312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.33792562
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.32403797
33Long-term potentiation_Homo sapiens_hsa047201.32058057
34Cholinergic synapse_Homo sapiens_hsa047251.30900562
35Dopaminergic synapse_Homo sapiens_hsa047281.29545599
36Serotonergic synapse_Homo sapiens_hsa047261.29511945
37Oxytocin signaling pathway_Homo sapiens_hsa049211.28965973
38Insulin secretion_Homo sapiens_hsa049111.26547026
39Calcium signaling pathway_Homo sapiens_hsa040201.26147827
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.23331460
41Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.21517642
42cGMP-PKG signaling pathway_Homo sapiens_hsa040221.19507768
43Protein export_Homo sapiens_hsa030601.19430680
44Axon guidance_Homo sapiens_hsa043601.18473073
45Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.17309851
46Long-term depression_Homo sapiens_hsa047301.14615779
47Amphetamine addiction_Homo sapiens_hsa050311.13388898
48beta-Alanine metabolism_Homo sapiens_hsa004101.11811758
49Vascular smooth muscle contraction_Homo sapiens_hsa042701.11792586
50Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.08401442
51Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.07519141
52Taste transduction_Homo sapiens_hsa047421.05392560
53Fatty acid degradation_Homo sapiens_hsa000711.04023202
54Aldosterone synthesis and secretion_Homo sapiens_hsa049251.03495327
55Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.02864674
56alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.02361621
57Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.02283888
58cAMP signaling pathway_Homo sapiens_hsa040241.00759511
59Linoleic acid metabolism_Homo sapiens_hsa005910.99481832
60Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.98345856
61Basal cell carcinoma_Homo sapiens_hsa052170.96668620
62Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.96655608
63Hedgehog signaling pathway_Homo sapiens_hsa043400.95656096
64Cocaine addiction_Homo sapiens_hsa050300.91468995
65Gap junction_Homo sapiens_hsa045400.90824544
66Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.88173669
67Type II diabetes mellitus_Homo sapiens_hsa049300.87575618
68Pancreatic secretion_Homo sapiens_hsa049720.86965970
69Pyruvate metabolism_Homo sapiens_hsa006200.86846502
70Ether lipid metabolism_Homo sapiens_hsa005650.86493832
71Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.86076302
72Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.84846502
73GnRH signaling pathway_Homo sapiens_hsa049120.84126130
74Fatty acid biosynthesis_Homo sapiens_hsa000610.78388307
75Glycerolipid metabolism_Homo sapiens_hsa005610.78291497
76Renal cell carcinoma_Homo sapiens_hsa052110.77417770
77Collecting duct acid secretion_Homo sapiens_hsa049660.76803657
78Hippo signaling pathway_Homo sapiens_hsa043900.75438029
79Regulation of autophagy_Homo sapiens_hsa041400.75255529
80Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.74315571
81Tight junction_Homo sapiens_hsa045300.73865090
82Steroid biosynthesis_Homo sapiens_hsa001000.71974519
83Selenocompound metabolism_Homo sapiens_hsa004500.71179339
84Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.70875286
85ECM-receptor interaction_Homo sapiens_hsa045120.70486388
86Phospholipase D signaling pathway_Homo sapiens_hsa040720.68587274
87Basal transcription factors_Homo sapiens_hsa030220.68098651
88Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.66189463
89Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.65395087
90Vibrio cholerae infection_Homo sapiens_hsa051100.65117608
91Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.63360440
92Starch and sucrose metabolism_Homo sapiens_hsa005000.62760464
93Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62257190
94Ovarian steroidogenesis_Homo sapiens_hsa049130.61953917
95AMPK signaling pathway_Homo sapiens_hsa041520.61822690
96Vitamin B6 metabolism_Homo sapiens_hsa007500.61771611
97Huntingtons disease_Homo sapiens_hsa050160.61600717
98Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.60175212
99Sulfur metabolism_Homo sapiens_hsa009200.59245036
100Glucagon signaling pathway_Homo sapiens_hsa049220.58684191
101Focal adhesion_Homo sapiens_hsa045100.58680927
102Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.58673497
103Phosphatidylinositol signaling system_Homo sapiens_hsa040700.58643168
104Carbon metabolism_Homo sapiens_hsa012000.58334982
105Retinol metabolism_Homo sapiens_hsa008300.57737482
106ErbB signaling pathway_Homo sapiens_hsa040120.57277013
107Adipocytokine signaling pathway_Homo sapiens_hsa049200.57271542
108ABC transporters_Homo sapiens_hsa020100.55918265
109Ras signaling pathway_Homo sapiens_hsa040140.55568290
110PPAR signaling pathway_Homo sapiens_hsa033200.55061683
111Peroxisome_Homo sapiens_hsa041460.54545992
112TGF-beta signaling pathway_Homo sapiens_hsa043500.53563795
113Melanogenesis_Homo sapiens_hsa049160.52872753
114RNA degradation_Homo sapiens_hsa030180.52741977
115Dorso-ventral axis formation_Homo sapiens_hsa043200.51446069
116Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.51321609
117Nitrogen metabolism_Homo sapiens_hsa009100.50489162
118Arginine and proline metabolism_Homo sapiens_hsa003300.49407217
119Lysine degradation_Homo sapiens_hsa003100.49058373
120Insulin signaling pathway_Homo sapiens_hsa049100.48827962
121Thyroid hormone synthesis_Homo sapiens_hsa049180.48705701
122Choline metabolism in cancer_Homo sapiens_hsa052310.47760750
123Estrogen signaling pathway_Homo sapiens_hsa049150.46979824
124Circadian rhythm_Homo sapiens_hsa047100.46969500
125Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.46882075
126Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.45420999
127Insulin resistance_Homo sapiens_hsa049310.42302453
128Sphingolipid signaling pathway_Homo sapiens_hsa040710.41231211
129Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.40956257
130MAPK signaling pathway_Homo sapiens_hsa040100.40927727
131Protein digestion and absorption_Homo sapiens_hsa049740.40850354
132Glycerophospholipid metabolism_Homo sapiens_hsa005640.38560588

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