VMA21

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a chaperone for assembly of lysosomal vacuolar ATPase. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1presynaptic membrane organization (GO:0097090)4.80656034
2neuron cell-cell adhesion (GO:0007158)4.77695280
3axon ensheathment in central nervous system (GO:0032291)4.65967683
4central nervous system myelination (GO:0022010)4.65967683
5presynaptic membrane assembly (GO:0097105)4.59505010
6DNA double-strand break processing (GO:0000729)4.44657563
7fatty acid elongation (GO:0030497)4.29919248
8neuronal action potential propagation (GO:0019227)3.98273278
9chromatin remodeling at centromere (GO:0031055)3.98120892
10mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.96933686
11CENP-A containing nucleosome assembly (GO:0034080)3.89530840
12synaptic vesicle exocytosis (GO:0016079)3.68918209
13lactate metabolic process (GO:0006089)3.65288357
14negative regulation of DNA-dependent DNA replication (GO:2000104)3.61977073
15chaperone-mediated protein transport (GO:0072321)3.59710327
16mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.55366227
17proteasome assembly (GO:0043248)3.54878231
18somatic diversification of immune receptors via somatic mutation (GO:0002566)3.54444021
19somatic hypermutation of immunoglobulin genes (GO:0016446)3.54444021
20ATP synthesis coupled proton transport (GO:0015986)3.52553843
21energy coupled proton transport, down electrochemical gradient (GO:0015985)3.52553843
22double-strand break repair via nonhomologous end joining (GO:0006303)3.47440376
23non-recombinational repair (GO:0000726)3.47440376
24mitotic sister chromatid cohesion (GO:0007064)3.45087002
25postsynaptic membrane organization (GO:0001941)3.43413067
26replication fork processing (GO:0031297)3.42957172
27establishment of integrated proviral latency (GO:0075713)3.37288626
28energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.35515853
29ATP hydrolysis coupled proton transport (GO:0015991)3.35515853
30resolution of meiotic recombination intermediates (GO:0000712)3.32268322
31DNA replication checkpoint (GO:0000076)3.30528545
32regulation of synaptic vesicle exocytosis (GO:2000300)3.30147344
33histone exchange (GO:0043486)3.30069694
34gamma-aminobutyric acid signaling pathway (GO:0007214)3.29670256
35negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.27842032
36negative regulation of neurotransmitter transport (GO:0051589)3.23533409
37respiratory electron transport chain (GO:0022904)3.21075318
38long-chain fatty acid biosynthetic process (GO:0042759)3.20784623
39regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.20541237
40negative regulation of synaptic transmission, GABAergic (GO:0032229)3.19939424
41transferrin transport (GO:0033572)3.18747714
42regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.18584747
43protein neddylation (GO:0045116)3.16627354
44mitochondrial fragmentation involved in apoptotic process (GO:0043653)3.15081864
45signal peptide processing (GO:0006465)3.13597160
46regulation of DNA endoreduplication (GO:0032875)3.12371884
47DNA ligation (GO:0006266)3.12319356
48protein localization to synapse (GO:0035418)3.10678683
49electron transport chain (GO:0022900)3.10440559
50glutamate secretion (GO:0014047)3.09361088
51protein localization to kinetochore (GO:0034501)3.07314499
52kinetochore organization (GO:0051383)3.07219420
53DNA damage response, detection of DNA damage (GO:0042769)3.04203068
54nuclear pore organization (GO:0006999)3.03374140
55ferric iron transport (GO:0015682)3.03040142
56trivalent inorganic cation transport (GO:0072512)3.03040142
57maturation of 5.8S rRNA (GO:0000460)3.02128832
58metaphase plate congression (GO:0051310)3.01177571
59vocalization behavior (GO:0071625)3.01094266
60maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.01058066
61neuron recognition (GO:0008038)3.00371474
62negative regulation of DNA recombination (GO:0045910)2.98728621
63neurotransmitter-gated ion channel clustering (GO:0072578)2.98701365
64protein complex biogenesis (GO:0070271)2.98611160
65spindle checkpoint (GO:0031577)2.98368652
66DNA strand renaturation (GO:0000733)2.98001698
67synapsis (GO:0007129)2.96487521
68purine nucleobase biosynthetic process (GO:0009113)2.96130072
69neurotransmitter uptake (GO:0001504)2.95423952
70mitotic metaphase plate congression (GO:0007080)2.95219115
71neuron-neuron synaptic transmission (GO:0007270)2.94601144
72substantia nigra development (GO:0021762)2.94422155
73mitochondrial respiratory chain complex I assembly (GO:0032981)2.94184286
74NADH dehydrogenase complex assembly (GO:0010257)2.94184286
75mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.94184286
76glutamate receptor signaling pathway (GO:0007215)2.93778985
77somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.93705484
78isotype switching (GO:0045190)2.93705484
79somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.93705484
80DNA strand elongation involved in DNA replication (GO:0006271)2.93577396
81DNA catabolic process, exonucleolytic (GO:0000738)2.93051326
82phagosome maturation (GO:0090382)2.92666580
83ionotropic glutamate receptor signaling pathway (GO:0035235)2.92008206
84DNA replication-independent nucleosome assembly (GO:0006336)2.91842301
85DNA replication-independent nucleosome organization (GO:0034724)2.91842301
86regulation of mitotic spindle checkpoint (GO:1903504)2.91418062
87regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.91418062
88regulation of centriole replication (GO:0046599)2.89336929
89mitotic spindle checkpoint (GO:0071174)2.88019703
90regulation of synaptic vesicle transport (GO:1902803)2.87221587
91synaptic vesicle docking involved in exocytosis (GO:0016081)2.85815222
92cerebellar granule cell differentiation (GO:0021707)2.84988686
93establishment of protein localization to mitochondrial membrane (GO:0090151)2.84485053
94pH reduction (GO:0045851)2.82199496
95positive regulation of synapse assembly (GO:0051965)2.80895527
96exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.80293925
97DNA strand elongation (GO:0022616)2.80100122
98long-term synaptic potentiation (GO:0060291)2.79524822
99regulation of short-term neuronal synaptic plasticity (GO:0048172)2.78429818
100nuclear pore complex assembly (GO:0051292)2.78071148
101negative regulation of sister chromatid segregation (GO:0033046)2.76882912
102negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.76882912
103negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.76882912
104negative regulation of mitotic sister chromatid segregation (GO:0033048)2.76882912
105negative regulation of mitotic sister chromatid separation (GO:2000816)2.76882912
106negative regulation of neurotransmitter secretion (GO:0046929)2.75417338
107behavioral response to cocaine (GO:0048148)2.75204407
108kinetochore assembly (GO:0051382)2.74456019
109regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.74007316
110regulation of mitotic metaphase/anaphase transition (GO:0030071)2.74007316
111negative regulation of chromosome segregation (GO:0051985)2.74003956
112nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.73862854
113ribosome assembly (GO:0042255)2.73407599
114telomere maintenance via semi-conservative replication (GO:0032201)2.72982894
115protein deneddylation (GO:0000338)2.72154006
116regulation of sister chromatid segregation (GO:0033045)2.70993947
117regulation of mitotic sister chromatid separation (GO:0010965)2.70993947
118regulation of mitotic sister chromatid segregation (GO:0033047)2.70993947
119synaptic transmission, glutamatergic (GO:0035249)2.70788062
120nucleotide-excision repair, DNA gap filling (GO:0006297)2.70460521
121positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.69948615
122RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.69337474
123nucleobase biosynthetic process (GO:0046112)2.69146243
124histone H2A acetylation (GO:0043968)2.69105759
125water-soluble vitamin biosynthetic process (GO:0042364)2.68949161
126respiratory chain complex IV assembly (GO:0008535)2.68826101
127regulation of glutamate receptor signaling pathway (GO:1900449)2.68609700
128DNA replication-dependent nucleosome organization (GO:0034723)2.68446580
129DNA replication-dependent nucleosome assembly (GO:0006335)2.68446580
130postreplication repair (GO:0006301)2.66893396
131peptidyl-histidine modification (GO:0018202)2.66875095
132intracellular pH reduction (GO:0051452)2.66571675
133spindle assembly checkpoint (GO:0071173)2.66304934
134regulation of helicase activity (GO:0051095)2.65844109
135axonal fasciculation (GO:0007413)2.65659188
136somatic recombination of immunoglobulin gene segments (GO:0016447)2.64060528
137mitotic spindle assembly checkpoint (GO:0007094)2.62447769
138recombinational repair (GO:0000725)2.61990883
139G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.61317164
140protein K6-linked ubiquitination (GO:0085020)2.60873281
141double-strand break repair via homologous recombination (GO:0000724)2.60550904
142response to pheromone (GO:0019236)2.59669924
143cerebral cortex radially oriented cell migration (GO:0021799)2.58242006
144regulation of voltage-gated calcium channel activity (GO:1901385)2.58117996
145regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.57988157
146mitotic recombination (GO:0006312)2.57397329
147regulation of chromosome segregation (GO:0051983)2.57393213
148regulation of glucokinase activity (GO:0033131)2.57202619
149regulation of hexokinase activity (GO:1903299)2.57202619
150sister chromatid segregation (GO:0000819)2.56154828
151tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.55972644
152RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.55972644
153neurotransmitter secretion (GO:0007269)2.55878422
154meiotic chromosome segregation (GO:0045132)2.55664928
155L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.55623641
156mitochondrial respiratory chain complex assembly (GO:0033108)2.55057458
157protein localization to cilium (GO:0061512)2.54516687
158response to X-ray (GO:0010165)2.53869215
159regulation of synaptic transmission, glutamatergic (GO:0051966)2.52749871
160regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.52043847
161somatic diversification of immunoglobulins (GO:0016445)2.51688931
162regulation of nuclear cell cycle DNA replication (GO:0033262)2.51005009
163transmission of nerve impulse (GO:0019226)2.50540335
164intraciliary transport (GO:0042073)2.50464785
165response to redox state (GO:0051775)2.50328184
166positive regulation of mitochondrial fission (GO:0090141)2.48782603
167startle response (GO:0001964)2.48691551
168IMP biosynthetic process (GO:0006188)2.48344360
169positive regulation of mitotic sister chromatid separation (GO:1901970)2.48117101
170positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.48117101
171regulation of long-term neuronal synaptic plasticity (GO:0048169)2.47157019
172cullin deneddylation (GO:0010388)2.46330172
173long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.45740063
174regulation of glutamate secretion (GO:0014048)2.45001797
175gamma-aminobutyric acid transport (GO:0015812)2.42097479
176hydrogen ion transmembrane transport (GO:1902600)2.40812474
177ER overload response (GO:0006983)2.40079311
178negative regulation of synaptic transmission (GO:0050805)2.40074987
179adult walking behavior (GO:0007628)2.39869070
180regulation of excitatory postsynaptic membrane potential (GO:0060079)2.39645662
181neurotransmitter transport (GO:0006836)2.39143334
182nonmotile primary cilium assembly (GO:0035058)2.38596835
183negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.37772265
184mechanosensory behavior (GO:0007638)2.37505213
185regulation of neuronal synaptic plasticity (GO:0048168)2.36186196
186long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.35537650
187myelination (GO:0042552)2.35273758
188response to histamine (GO:0034776)2.34219980
189membrane assembly (GO:0071709)2.33908882
190proton transport (GO:0015992)2.33769944
191positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.33488121
192regulation of neurotransmitter secretion (GO:0046928)2.32398909
193mannosylation (GO:0097502)2.32128091
194regulation of catecholamine metabolic process (GO:0042069)2.31097534
195regulation of dopamine metabolic process (GO:0042053)2.31097534
196nucleotide transmembrane transport (GO:1901679)2.30918972
197hydrogen transport (GO:0006818)2.30903452
198ensheathment of neurons (GO:0007272)2.29360888

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.52139775
2GBX2_23144817_ChIP-Seq_PC3_Human4.21918356
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.83521329
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.33388472
5TAF15_26573619_Chip-Seq_HEK293_Human3.22824247
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.18790243
7GABP_17652178_ChIP-ChIP_JURKAT_Human2.93504673
8EZH2_22144423_ChIP-Seq_EOC_Human2.71617509
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.65285021
10SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.63594109
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.62432757
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.55003969
13ELK1_19687146_ChIP-ChIP_HELA_Human2.52959379
14ZNF274_21170338_ChIP-Seq_K562_Hela2.50579743
15SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.48495295
16TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.47488309
17JARID2_20064375_ChIP-Seq_MESCs_Mouse2.45797082
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.44400763
19POU3F2_20337985_ChIP-ChIP_501MEL_Human2.43965506
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.34260559
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.33471714
22SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.26225403
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.26125219
24EED_16625203_ChIP-ChIP_MESCs_Mouse2.22034097
25E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.19370061
26IGF1R_20145208_ChIP-Seq_DFB_Human2.19364767
27SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.18085229
28CTBP2_25329375_ChIP-Seq_LNCAP_Human2.14937972
29AR_21572438_ChIP-Seq_LNCaP_Human2.13589915
30P300_19829295_ChIP-Seq_ESCs_Human2.12622616
31RBPJ_22232070_ChIP-Seq_NCS_Mouse2.10852885
32SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.09840845
33EZH2_27304074_Chip-Seq_ESCs_Mouse2.09278278
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.08848523
35FOXM1_23109430_ChIP-Seq_U2OS_Human2.08340413
36KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.04608724
37OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.02515925
38FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.99395580
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.99330184
40MYC_18555785_ChIP-Seq_MESCs_Mouse1.96257409
41JARID2_20075857_ChIP-Seq_MESCs_Mouse1.96001233
42RNF2_18974828_ChIP-Seq_MESCs_Mouse1.95883986
43EZH2_18974828_ChIP-Seq_MESCs_Mouse1.95883986
44CREB1_15753290_ChIP-ChIP_HEK293T_Human1.94912475
45FUS_26573619_Chip-Seq_HEK293_Human1.94234195
46MTF2_20144788_ChIP-Seq_MESCs_Mouse1.92525198
47SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.91449454
48ER_23166858_ChIP-Seq_MCF-7_Human1.90875617
49VDR_23849224_ChIP-Seq_CD4+_Human1.90333370
50CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.90047488
51NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.84950006
52VDR_22108803_ChIP-Seq_LS180_Human1.84557633
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.82808536
54ETS1_20019798_ChIP-Seq_JURKAT_Human1.81684730
55PADI4_21655091_ChIP-ChIP_MCF-7_Human1.80259770
56SMAD4_21799915_ChIP-Seq_A2780_Human1.73176110
57JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.71147276
58FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.69998885
59CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.65306255
60TOP2B_26459242_ChIP-Seq_MCF-7_Human1.62588648
61BMI1_23680149_ChIP-Seq_NPCS_Mouse1.61990203
62REST_21632747_ChIP-Seq_MESCs_Mouse1.61952230
63CBX2_27304074_Chip-Seq_ESCs_Mouse1.58850035
64BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.57859169
65NRF2_20460467_ChIP-Seq_MEFs_Mouse1.57330907
66NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.57330907
67NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.56834910
68PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.56595978
69EZH2_27294783_Chip-Seq_ESCs_Mouse1.56199102
70SMAD3_21741376_ChIP-Seq_EPCs_Human1.55788425
71FOXP3_21729870_ChIP-Seq_TREG_Human1.55640271
72PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.54910860
73SUZ12_27294783_Chip-Seq_ESCs_Mouse1.54774968
74POU5F1_16153702_ChIP-ChIP_HESCs_Human1.54498236
75MYC_18940864_ChIP-ChIP_HL60_Human1.53352687
76YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.53333047
77HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.46083601
78RNF2_27304074_Chip-Seq_ESCs_Mouse1.44741672
79MYC_19030024_ChIP-ChIP_MESCs_Mouse1.44521306
80EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.43231125
81NANOG_18555785_Chip-Seq_ESCs_Mouse1.42991142
82AR_21909140_ChIP-Seq_LNCAP_Human1.42565026
83E2F1_21310950_ChIP-Seq_MCF-7_Human1.40531106
84UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.39980037
85FLI1_27457419_Chip-Seq_LIVER_Mouse1.37858496
86AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.37192113
87FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.35325740
88TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.34290632
89SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34251011
90DCP1A_22483619_ChIP-Seq_HELA_Human1.34153356
91P53_22387025_ChIP-Seq_ESCs_Mouse1.33086249
92REST_18959480_ChIP-ChIP_MESCs_Mouse1.32659037
93PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.32603514
94AR_25329375_ChIP-Seq_VCAP_Human1.32533288
95THAP11_20581084_ChIP-Seq_MESCs_Mouse1.31550894
96EWS_26573619_Chip-Seq_HEK293_Human1.31034656
97TP53_18474530_ChIP-ChIP_U2OS_Human1.30375657
98PCGF2_27294783_Chip-Seq_ESCs_Mouse1.29248020
99CMYC_18555785_Chip-Seq_ESCs_Mouse1.29221572
100SUZ12_18555785_Chip-Seq_ESCs_Mouse1.28129878
101NR3C1_23031785_ChIP-Seq_PC12_Mouse1.25304409
102GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.24297156
103JUN_21703547_ChIP-Seq_K562_Human1.24059108
104MYCN_18555785_ChIP-Seq_MESCs_Mouse1.23859616
105RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.23021251
106E2F1_18555785_Chip-Seq_ESCs_Mouse1.22332320
107SRF_21415370_ChIP-Seq_HL-1_Mouse1.22038099
108RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.21576620
109NELFA_20434984_ChIP-Seq_ESCs_Mouse1.21467502
110NOTCH1_21737748_ChIP-Seq_TLL_Human1.19452285
111EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.19029811
112IKZF1_21737484_ChIP-ChIP_HCT116_Human1.18904454
113HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.18872159
114STAT3_18555785_Chip-Seq_ESCs_Mouse1.18396171
115RNF2_27304074_Chip-Seq_NSC_Mouse1.17774430
116P300_18555785_Chip-Seq_ESCs_Mouse1.16271151
117SOX2_16153702_ChIP-ChIP_HESCs_Human1.15823850
118CDX2_19796622_ChIP-Seq_MESCs_Mouse1.15802107
119GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.15700785
120TTF2_22483619_ChIP-Seq_HELA_Human1.15377691
121NANOG_19829295_ChIP-Seq_ESCs_Human1.15078381
122SOX2_19829295_ChIP-Seq_ESCs_Human1.15078381
123SOX2_18555785_Chip-Seq_ESCs_Mouse1.15053840
124RUNX1_27457419_Chip-Seq_LIVER_Mouse1.14621666
125SOX2_21211035_ChIP-Seq_LN229_Gbm1.14609511
126STAT3_23295773_ChIP-Seq_U87_Human1.14121437
127E2F1_18555785_ChIP-Seq_MESCs_Mouse1.14046605
128SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.13828087
129TRIM28_21343339_ChIP-Seq_HEK293_Human1.13289141
130GABP_19822575_ChIP-Seq_HepG2_Human1.13165964
131NANOG_16153702_ChIP-ChIP_HESCs_Human1.12166200
132MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.11674671
133PRDM14_20953172_ChIP-Seq_ESCs_Human1.10885917
134TAL1_26923725_Chip-Seq_HPCs_Mouse1.10680056
135HOXB4_20404135_ChIP-ChIP_EML_Mouse1.09760298
136HTT_18923047_ChIP-ChIP_STHdh_Human1.09727766
137RUNX2_22187159_ChIP-Seq_PCA_Human1.09104364
138DROSHA_22980978_ChIP-Seq_HELA_Human1.08843913
139EZH2_27294783_Chip-Seq_NPCs_Mouse1.07379219
140TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06404549
141ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.06142203
142NMYC_18555785_Chip-Seq_ESCs_Mouse1.05994145
143MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.05880353
144ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.05860404
145IRF1_19129219_ChIP-ChIP_H3396_Human1.05714519
146MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.05608537
147HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.05500813
148WT1_19549856_ChIP-ChIP_CCG9911_Human1.04806405
149MYC_18358816_ChIP-ChIP_MESCs_Mouse1.04461365
150CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.04412916
151SUZ12_27294783_Chip-Seq_NPCs_Mouse1.04345568
152TCF4_23295773_ChIP-Seq_U87_Human1.03916988
153TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03795818
154IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.03530439
155CBP_20019798_ChIP-Seq_JUKART_Human1.03530439
156PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.03524519
157POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.98329117
158SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.98150718
159ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.97066541
160MYC_19079543_ChIP-ChIP_MESCs_Mouse0.95846081
161ELF1_17652178_ChIP-ChIP_JURKAT_Human0.95370929
162POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.93608987
163TP53_22573176_ChIP-Seq_HFKS_Human0.93534245
164NFE2_27457419_Chip-Seq_LIVER_Mouse0.93125335

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.49978107
2MP0004859_abnormal_synaptic_plasticity3.33096181
3MP0008058_abnormal_DNA_repair3.24852503
4MP0010094_abnormal_chromosome_stability3.24586901
5MP0008057_abnormal_DNA_replication3.18844613
6MP0004270_analgesia3.06156102
7MP0002064_seizures2.85005771
8MP0008877_abnormal_DNA_methylation2.82890838
9MP0003635_abnormal_synaptic_transmissio2.82141887
10MP0009745_abnormal_behavioral_response2.80187622
11MP0002736_abnormal_nociception_after2.69590520
12MP0001968_abnormal_touch/_nociception2.60830636
13MP0009046_muscle_twitch2.60755429
14MP0000920_abnormal_myelination2.57839039
15MP0002102_abnormal_ear_morphology2.52081622
16MP0002272_abnormal_nervous_system2.51336641
17MP0005423_abnormal_somatic_nervous2.50474690
18MP0002063_abnormal_learning/memory/cond2.37416200
19MP0002734_abnormal_mechanical_nocicepti2.36923212
20MP0005646_abnormal_pituitary_gland2.25924704
21MP0003111_abnormal_nucleus_morphology2.24356003
22MP0001529_abnormal_vocalization2.19368902
23MP0002572_abnormal_emotion/affect_behav2.17787645
24MP0004957_abnormal_blastocyst_morpholog2.14454196
25MP0003787_abnormal_imprinting2.14448346
26MP0001486_abnormal_startle_reflex2.12757794
27MP0003693_abnormal_embryo_hatching2.12738564
28MP0006072_abnormal_retinal_apoptosis2.02097559
29MP0003121_genomic_imprinting1.98374864
30MP0005645_abnormal_hypothalamus_physiol1.95062633
31MP0003077_abnormal_cell_cycle1.94283579
32MP0006276_abnormal_autonomic_nervous1.91704517
33MP0001501_abnormal_sleep_pattern1.91447768
34MP0002067_abnormal_sensory_capabilities1.90367630
35MP0008007_abnormal_cellular_replicative1.86592932
36MP0002876_abnormal_thyroid_physiology1.84677936
37MP0001905_abnormal_dopamine_level1.84419859
38MP0004742_abnormal_vestibular_system1.82412386
39MP0001440_abnormal_grooming_behavior1.82314281
40MP0008932_abnormal_embryonic_tissue1.80317800
41MP0003718_maternal_effect1.77510823
42MP0004142_abnormal_muscle_tone1.77267501
43MP0002938_white_spotting1.75645312
44MP0002735_abnormal_chemical_nociception1.75622134
45MP0000778_abnormal_nervous_system1.68612034
46MP0006292_abnormal_olfactory_placode1.65717229
47MP0002733_abnormal_thermal_nociception1.60995995
48MP0003123_paternal_imprinting1.59454270
49MP0003786_premature_aging1.58829791
50MP0001970_abnormal_pain_threshold1.58462867
51MP0003890_abnormal_embryonic-extraembry1.57317924
52MP0003195_calcinosis1.54479603
53MP0005253_abnormal_eye_physiology1.52778559
54MP0001984_abnormal_olfaction1.50728998
55MP0003690_abnormal_glial_cell1.48622306
56MP0003937_abnormal_limbs/digits/tail_de1.48298990
57MP0005386_behavior/neurological_phenoty1.45234635
58MP0004924_abnormal_behavior1.45234635
59MP0003879_abnormal_hair_cell1.44507789
60MP0001293_anophthalmia1.43652040
61MP0006035_abnormal_mitochondrial_morpho1.43207594
62MP0010386_abnormal_urinary_bladder1.41847081
63MP0005551_abnormal_eye_electrophysiolog1.41783688
64MP0003329_amyloid_beta_deposits1.39030744
65MP0009780_abnormal_chondrocyte_physiolo1.38427664
66MP0000013_abnormal_adipose_tissue1.37497521
67MP0002184_abnormal_innervation1.36684046
68MP0001188_hyperpigmentation1.36379590
69MP0005367_renal/urinary_system_phenotyp1.33993123
70MP0000516_abnormal_urinary_system1.33993123
71MP0010352_gastrointestinal_tract_polyps1.31389990
72MP0001502_abnormal_circadian_rhythm1.30235294
73MP0000569_abnormal_digit_pigmentation1.29670455
74MP0002066_abnormal_motor_capabilities/c1.29383890
75MP0003634_abnormal_glial_cell1.29204671
76MP0002229_neurodegeneration1.29051076
77MP0005409_darkened_coat_color1.28343258
78MP0003724_increased_susceptibility_to1.26250182
79MP0010234_abnormal_vibrissa_follicle1.23723936
80MP0001963_abnormal_hearing_physiology1.23612951
81MP0002837_dystrophic_cardiac_calcinosis1.21886147
82MP0002160_abnormal_reproductive_system1.21448870
83MP0003172_abnormal_lysosome_physiology1.19878421
84MP0002751_abnormal_autonomic_nervous1.19189136
85MP0008569_lethality_at_weaning1.17838084
86MP0000647_abnormal_sebaceous_gland1.17816109
87MP0000955_abnormal_spinal_cord1.17671475
88MP0002234_abnormal_pharynx_morphology1.17606578
89MP0003183_abnormal_peptide_metabolism1.17590781
90MP0005171_absent_coat_pigmentation1.16640826
91MP0002882_abnormal_neuron_morphology1.16466261
92MP0004133_heterotaxia1.15672236
93MP0004145_abnormal_muscle_electrophysio1.15468932
94MP0003633_abnormal_nervous_system1.14189447
95MP0008789_abnormal_olfactory_epithelium1.13777962
96MP0004043_abnormal_pH_regulation1.13633021
97MP0010307_abnormal_tumor_latency1.13553831
98MP0002557_abnormal_social/conspecific_i1.11349659
99MP0005187_abnormal_penis_morphology1.09051747
100MP0001542_abnormal_bone_strength1.08142020
101MP0003631_nervous_system_phenotype1.07464749
102MP0000427_abnormal_hair_cycle1.06119913
103MP0006082_CNS_inflammation1.06044613
104MP0001929_abnormal_gametogenesis1.05967922
105MP0004811_abnormal_neuron_physiology1.04895985
106MP0000358_abnormal_cell_content/1.04094791
107MP0005391_vision/eye_phenotype1.03895728
108MP0002090_abnormal_vision1.03562563
109MP0002233_abnormal_nose_morphology1.02106969
110MP0005379_endocrine/exocrine_gland_phen1.00996521
111MP0002210_abnormal_sex_determination0.99463483
112MP0000631_abnormal_neuroendocrine_gland0.98375022
113MP0002084_abnormal_developmental_patter0.98306111
114MP0005535_abnormal_body_temperature0.97516284
115MP0005084_abnormal_gallbladder_morpholo0.95759385
116MP0003119_abnormal_digestive_system0.95322410
117MP0003567_abnormal_fetal_cardiomyocyte0.95253675
118MP0003632_abnormal_nervous_system0.95002036
119MP0000604_amyloidosis0.94624639
120MP0000653_abnormal_sex_gland0.93558777
121MP0004885_abnormal_endolymph0.93477966
122MP0004197_abnormal_fetal_growth/weight/0.93045200
123MP0008995_early_reproductive_senescence0.92685328
124MP0001286_abnormal_eye_development0.91346761
125MP0001145_abnormal_male_reproductive0.91226125
126MP0001697_abnormal_embryo_size0.90785961
127MP0004215_abnormal_myocardial_fiber0.90706494
128MP0005394_taste/olfaction_phenotype0.89989438
129MP0005499_abnormal_olfactory_system0.89989438
130MP0003122_maternal_imprinting0.89766509
131MP0001986_abnormal_taste_sensitivity0.87452105
132MP0009379_abnormal_foot_pigmentation0.85024012
133MP0000026_abnormal_inner_ear0.84163438
134MP0001485_abnormal_pinna_reflex0.83877476
135MP0003136_yellow_coat_color0.83075300
136MP0005380_embryogenesis_phenotype0.82475555
137MP0001672_abnormal_embryogenesis/_devel0.82475555
138MP0002085_abnormal_embryonic_tissue0.82456623
139MP0003011_delayed_dark_adaptation0.82031147
140MP0005058_abnormal_lysosome_morphology0.80657610
141MP0003656_abnormal_erythrocyte_physiolo0.80229397
142MP0005248_abnormal_Harderian_gland0.79438392
143MP0000350_abnormal_cell_proliferation0.79070017
144MP0003861_abnormal_nervous_system0.78989709
145MP0004147_increased_porphyrin_level0.78841751
146MP0001730_embryonic_growth_arrest0.77499468
147MP0005389_reproductive_system_phenotype0.76461389
148MP0002697_abnormal_eye_size0.76414200
149MP0003698_abnormal_male_reproductive0.75862734
150MP0002752_abnormal_somatic_nervous0.75300894
151MP0000681_abnormal_thyroid_gland0.75211982
152MP0004134_abnormal_chest_morphology0.74417798
153MP0000372_irregular_coat_pigmentation0.73655539
154MP0009697_abnormal_copulation0.73264760
155MP0001177_atelectasis0.72250532
156MP0002069_abnormal_eating/drinking_beha0.72143665
157MP0002909_abnormal_adrenal_gland0.71602163
158MP0002163_abnormal_gland_morphology0.70501795
159MP0001299_abnormal_eye_distance/0.68107632
160MP0002638_abnormal_pupillary_reflex0.66206442
161MP0006036_abnormal_mitochondrial_physio0.66066988
162MP0008875_abnormal_xenobiotic_pharmacok0.64690277
163MP0002152_abnormal_brain_morphology0.64347965
164MP0008874_decreased_physiological_sensi0.64308071
165MP0002139_abnormal_hepatobiliary_system0.61949406
166MP0001764_abnormal_homeostasis0.59364277

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.91288576
2Acute necrotizing encephalopathy (HP:0006965)4.47950561
3Abnormal mitochondria in muscle tissue (HP:0008316)4.20189043
4Mitochondrial inheritance (HP:0001427)3.93264258
5Atonic seizures (HP:0010819)3.85068477
6Progressive macrocephaly (HP:0004481)3.82460757
7Acute encephalopathy (HP:0006846)3.78795753
8Hepatocellular necrosis (HP:0001404)3.73195354
9Hyperventilation (HP:0002883)3.51758768
10Increased serum pyruvate (HP:0003542)3.49094113
11Abnormality of glycolysis (HP:0004366)3.49094113
12Pheochromocytoma (HP:0002666)3.45275937
13Visual hallucinations (HP:0002367)3.43771108
14Epileptic encephalopathy (HP:0200134)3.37716296
15Neuroendocrine neoplasm (HP:0100634)3.37490205
16Renal Fanconi syndrome (HP:0001994)3.29468954
17Increased CSF lactate (HP:0002490)3.26465313
18Absence seizures (HP:0002121)3.21885158
19Myokymia (HP:0002411)3.14722692
20Dialeptic seizures (HP:0011146)3.13175296
21Colon cancer (HP:0003003)3.09210261
22Abnormality of the labia minora (HP:0012880)3.03449003
23Akinesia (HP:0002304)2.99386384
24Hepatic necrosis (HP:0002605)2.97607694
25Chromosomal breakage induced by crosslinking agents (HP:0003221)2.91149774
26Chromsome breakage (HP:0040012)2.89460519
27Leukodystrophy (HP:0002415)2.89140645
28Abnormality of chromosome stability (HP:0003220)2.89005438
29Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.87373972
30Focal seizures (HP:0007359)2.83337684
31Neurofibrillary tangles (HP:0002185)2.80258383
32Neoplasm of the adrenal cortex (HP:0100641)2.77883496
33Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.77813943
34Degeneration of the lateral corticospinal tracts (HP:0002314)2.77813943
35Progressive inability to walk (HP:0002505)2.77674722
36Volvulus (HP:0002580)2.76104316
37Parakeratosis (HP:0001036)2.74968197
38Hypoglycemic seizures (HP:0002173)2.72607604
39Generalized tonic-clonic seizures (HP:0002069)2.70451090
40Increased neuronal autofluorescent lipopigment (HP:0002074)2.64866872
41Aplasia/Hypoplasia of the uvula (HP:0010293)2.63807342
42Intestinal atresia (HP:0011100)2.63747092
43Hypothermia (HP:0002045)2.62335649
44Optic disc pallor (HP:0000543)2.58670521
45Hypoglycemic coma (HP:0001325)2.57649284
46Meckel diverticulum (HP:0002245)2.56577680
47Hyperinsulinemic hypoglycemia (HP:0000825)2.53661576
48Increased hepatocellular lipid droplets (HP:0006565)2.52411028
49Abnormality of the ileum (HP:0001549)2.51570616
50Sensory axonal neuropathy (HP:0003390)2.49911801
51Termporal pattern (HP:0011008)2.48736352
52Insidious onset (HP:0003587)2.48736352
53Ependymoma (HP:0002888)2.47061437
54Medial flaring of the eyebrow (HP:0010747)2.46644658
55Glioma (HP:0009733)2.46489530
56Abnormality of the metopic suture (HP:0005556)2.44388212
57Gait imbalance (HP:0002141)2.43730975
58Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.42245762
59Anxiety (HP:0000739)2.39756959
60Fetal akinesia sequence (HP:0001989)2.39658081
61Cerebral edema (HP:0002181)2.39031077
62Broad-based gait (HP:0002136)2.38090929
63Febrile seizures (HP:0002373)2.37512374
64Respiratory failure (HP:0002878)2.37459336
65Pancreatic cysts (HP:0001737)2.36890909
66Abnormality of renal resorption (HP:0011038)2.36771790
67Pancreatic fibrosis (HP:0100732)2.31834136
68Abnormal eating behavior (HP:0100738)2.31283493
69Increased cerebral lipofuscin (HP:0011813)2.31141794
70Congenital primary aphakia (HP:0007707)2.28802129
71Abnormality of the astrocytes (HP:0100707)2.26186868
72Astrocytoma (HP:0009592)2.26186868
73Prominent metopic ridge (HP:0005487)2.26147867
74Poor suck (HP:0002033)2.25202315
753-Methylglutaconic aciduria (HP:0003535)2.23145130
76Abnormality of the preputium (HP:0100587)2.22150908
77Rhabdomyosarcoma (HP:0002859)2.20348497
78Medulloblastoma (HP:0002885)2.20334123
79Diminished movement (HP:0002374)2.20073864
80Neoplasm of the adrenal gland (HP:0100631)2.17056045
81Supranuclear gaze palsy (HP:0000605)2.16565477
82Lipid accumulation in hepatocytes (HP:0006561)2.16127141
83Mutism (HP:0002300)2.15509733
84X-linked dominant inheritance (HP:0001423)2.14942400
85Exercise intolerance (HP:0003546)2.14329786
86Inability to walk (HP:0002540)2.10618661
87Cortical dysplasia (HP:0002539)2.10562178
88Nephrogenic diabetes insipidus (HP:0009806)2.09687252
89Abnormal lung lobation (HP:0002101)2.08905138
90Abnormality of the corticospinal tract (HP:0002492)2.08335314
91Cerebral inclusion bodies (HP:0100314)2.08067917
92Epileptiform EEG discharges (HP:0011182)2.06152595
93Nephronophthisis (HP:0000090)2.05100661
94Abnormal pupillary function (HP:0007686)2.04206428
95Increased intramyocellular lipid droplets (HP:0012240)2.02140871
96Lactic acidosis (HP:0003128)2.01729502
97Autoamputation (HP:0001218)2.01486461
98Sloping forehead (HP:0000340)2.00205934
99Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.99322534
100Birth length less than 3rd percentile (HP:0003561)1.98112044
101Pancreatic islet-cell hyperplasia (HP:0004510)1.98016241
102Generalized myoclonic seizures (HP:0002123)1.97443449
103Agitation (HP:0000713)1.96242236
104Small intestinal stenosis (HP:0012848)1.96048928
105Duodenal stenosis (HP:0100867)1.96048928
106Methylmalonic acidemia (HP:0002912)1.95565548
107Abnormality of the duodenum (HP:0002246)1.93954659
108Polyphagia (HP:0002591)1.93464882
109Abnormality of the pancreatic islet cells (HP:0006476)1.92963908
110Abnormality of endocrine pancreas physiology (HP:0012093)1.92963908
111Vaginal atresia (HP:0000148)1.92955438
112Action tremor (HP:0002345)1.92497374
113Hepatoblastoma (HP:0002884)1.91432253
114Breast carcinoma (HP:0003002)1.91067855
115Gastrointestinal atresia (HP:0002589)1.90997984
116Symptomatic seizures (HP:0011145)1.89151992
117Genital tract atresia (HP:0001827)1.89122875
118EEG with generalized epileptiform discharges (HP:0011198)1.88971720
119Limb dystonia (HP:0002451)1.88460494
120Molar tooth sign on MRI (HP:0002419)1.87522457
121Abnormality of midbrain morphology (HP:0002418)1.87522457
122Nephroblastoma (Wilms tumor) (HP:0002667)1.87167918
123J-shaped sella turcica (HP:0002680)1.86968483
124Renal cortical cysts (HP:0000803)1.84461341
125Postnatal microcephaly (HP:0005484)1.83948270
126Scanning speech (HP:0002168)1.83710748
127Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.82810353
128Blue irides (HP:0000635)1.82259101
129Ankle clonus (HP:0011448)1.82035129
130Embryonal renal neoplasm (HP:0011794)1.81329795
131True hermaphroditism (HP:0010459)1.80914988
132Thyroid carcinoma (HP:0002890)1.80579408
133Spastic gait (HP:0002064)1.80526597
134Thickened helices (HP:0000391)1.79898414
135Dysmetria (HP:0001310)1.79220409
136Cerebral hemorrhage (HP:0001342)1.77931783
137Abnormality of the renal cortex (HP:0011035)1.77219116
138Protruding tongue (HP:0010808)1.76164730
139Muscular hypotonia of the trunk (HP:0008936)1.76031689
140Drooling (HP:0002307)1.75106135
141Excessive salivation (HP:0003781)1.75106135
142Neoplasm of the colon (HP:0100273)1.73989964
143Progressive cerebellar ataxia (HP:0002073)1.73793894
144Neoplasm of the oral cavity (HP:0100649)1.72859265
145Aqueductal stenosis (HP:0002410)1.72163376
146Abnormality of alanine metabolism (HP:0010916)1.72148179
147Hyperalaninemia (HP:0003348)1.72148179
148Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.72148179
149Hypsarrhythmia (HP:0002521)1.70828964
150Abnormality of the renal medulla (HP:0100957)1.70397697
151Peripheral hypomyelination (HP:0007182)1.70327598
152Preaxial hand polydactyly (HP:0001177)1.69634305
153Biliary tract neoplasm (HP:0100574)1.68995349
154Retinal dysplasia (HP:0007973)1.67949807
155Increased serum lactate (HP:0002151)1.67902154
156Vacuolated lymphocytes (HP:0001922)1.65975827
157Clumsiness (HP:0002312)1.65745323
158Poor eye contact (HP:0000817)1.64841378
159Lissencephaly (HP:0001339)1.64654231
160Postaxial hand polydactyly (HP:0001162)1.64330072
161Abnormality of methionine metabolism (HP:0010901)1.63461424
162Hyperglycinemia (HP:0002154)1.63212985
163Esotropia (HP:0000565)1.62919675
164Ectopic kidney (HP:0000086)1.62619326
165Short tibia (HP:0005736)1.62255851
166Hypoplastic pelvis (HP:0008839)1.62128095
167Papillary thyroid carcinoma (HP:0002895)1.61903323
168Oligodactyly (hands) (HP:0001180)1.61601059
169Clubbing of toes (HP:0100760)1.61313755
170Abnormality of the carotid arteries (HP:0005344)1.59386765
171Triphalangeal thumb (HP:0001199)1.59271914

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.86777052
2MAP3K123.54175073
3FRK3.32231427
4MAP2K73.08541549
5TRIM282.78481626
6OXSR12.74363973
7TSSK62.61111989
8NTRK32.60334951
9ZAK2.59164425
10BUB12.47842124
11NEK12.38672206
12STK392.37135704
13SRPK12.35189957
14CDK192.28969450
15PLK32.23931709
16CDC72.23764920
17MKNK22.19438488
18PLK22.18132122
19MAP3K42.08128995
20TTK2.04055424
21PRPF4B2.01191880
22MKNK11.96473860
23WEE11.96439272
24EPHA41.89783501
25NUAK11.83080165
26BCR1.80078713
27RIPK41.79412533
28MAP4K21.72159185
29EIF2AK11.71585902
30LIMK11.70754324
31BRSK21.70279777
32BMPR21.66352879
33MAP2K41.64452694
34PBK1.62531502
35CCNB11.56776994
36MINK11.56327348
37CSNK1G11.52750324
38PLK41.50538963
39MARK11.49502525
40TNIK1.48992847
41ACVR1B1.43544318
42PLK11.40036028
43MAPKAPK51.37595385
44NEK61.37191530
45CAMK2B1.36807959
46VRK11.36367232
47TAF11.36152753
48EIF2AK31.31837080
49ARAF1.31811919
50DAPK21.31730995
51NME11.28065665
52VRK21.26194399
53STK31.22163786
54GRK71.17988700
55CAMKK21.13953532
56FGFR21.13435142
57CAMK2A1.11791678
58GRK51.09446631
59CDK141.07961064
60BMPR1B1.07717269
61PRKCE1.07638573
62MAPK131.06140248
63NTRK11.05270753
64CDK51.05114462
65MUSK1.04667675
66SGK4941.04586945
67SGK2231.04586945
68ERBB31.03586780
69CAMK2D1.02280531
70WNK41.01545220
71ATR0.99951306
72UHMK10.96032520
73STK38L0.94273997
74MAP3K130.93732055
75PRKCG0.93584869
76EIF2AK20.92622409
77CDK80.92291775
78FES0.92123867
79YES10.91438559
80BRSK10.90299924
81CDK180.88605668
82EPHA30.88561021
83PKN10.88376843
84ATM0.87712847
85ERBB40.87394122
86PINK10.87275711
87CHEK20.85564228
88CDK150.83984482
89PAK60.83565635
90CDK30.79640380
91CAMK2G0.78534474
92FGR0.78397471
93PAK30.75468664
94GRK10.73827996
95ROCK20.72498374
96STK160.71378026
97CDK11A0.70961019
98CSNK1G30.69647119
99RPS6KA40.69245582
100AURKB0.68765760
101ADRBK20.68739732
102BRD40.68472652
103PRKCQ0.68265414
104SCYL20.67855735
105DYRK20.67537900
106WNK30.66713422
107DYRK30.66537514
108MAP3K90.65433564
109MOS0.65224005
110IRAK10.64944255
111TGFBR10.63772468
112PIM20.63746535
113CSNK1G20.62506207
114IRAK20.62367815
115MAP3K140.62190884
116BCKDK0.61352428
117AKT30.58011367
118CHEK10.57913053
119ABL20.56909948
120MAP3K10.56746677
121MAPK70.55688877
122ADRBK10.54724958
123WNK10.54193443
124LATS10.53486828
125PRKG10.53168318
126PASK0.52612305
127DYRK1A0.51628965
128PTK2B0.49816451
129PHKG10.48499461
130PHKG20.48499461
131PNCK0.48262174
132CSNK1A1L0.47687010
133PRKACA0.47308505
134NEK20.47230905
135INSRR0.47046450
136IRAK40.46765159
137KSR20.46327165
138MST40.45654554
139SGK20.44805838
140CSNK1E0.44388941
141PDPK10.44297451
142FLT30.43592424
143DAPK10.43439780
144RPS6KA50.42786867
145EPHB10.42336579
146STK40.42155206
147FGFR10.41754217
148MAPK120.40378619
149PDK20.40046034
150FYN0.39715055
151CSNK1D0.39353621
152SGK10.38386351
153KSR10.38289525
154PRKDC0.38143988
155FER0.37737932
156CDK10.36968080
157CSNK2A20.34809841
158CSNK2A10.34764071
159TLK10.34587011
160STK240.32323815

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.74506316
2Non-homologous end-joining_Homo sapiens_hsa034503.38837563
3Collecting duct acid secretion_Homo sapiens_hsa049663.13473952
4Mismatch repair_Homo sapiens_hsa034303.04150539
5Protein export_Homo sapiens_hsa030602.91115081
6Nicotine addiction_Homo sapiens_hsa050332.90202180
7Synaptic vesicle cycle_Homo sapiens_hsa047212.79217677
8DNA replication_Homo sapiens_hsa030302.78979947
9Parkinsons disease_Homo sapiens_hsa050122.75208394
10Homologous recombination_Homo sapiens_hsa034402.58398324
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.55296404
12Fanconi anemia pathway_Homo sapiens_hsa034602.52228639
13Alzheimers disease_Homo sapiens_hsa050102.48291039
14Fatty acid elongation_Homo sapiens_hsa000622.42347739
15Vibrio cholerae infection_Homo sapiens_hsa051102.40880584
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.31353651
17Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.25288394
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.23994287
19GABAergic synapse_Homo sapiens_hsa047272.22074614
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.17763707
21RNA transport_Homo sapiens_hsa030132.09360246
22RNA polymerase_Homo sapiens_hsa030202.05497487
23Basal transcription factors_Homo sapiens_hsa030222.04551473
24Steroid biosynthesis_Homo sapiens_hsa001001.99715559
25RNA degradation_Homo sapiens_hsa030181.92368713
26SNARE interactions in vesicular transport_Homo sapiens_hsa041301.88592934
27Circadian entrainment_Homo sapiens_hsa047131.86458892
28Nucleotide excision repair_Homo sapiens_hsa034201.86391033
29Morphine addiction_Homo sapiens_hsa050321.86294756
30Glutamatergic synapse_Homo sapiens_hsa047241.82022834
31Rheumatoid arthritis_Homo sapiens_hsa053231.79369484
32Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.77366635
33Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.77251885
34Base excision repair_Homo sapiens_hsa034101.76657440
35Cell cycle_Homo sapiens_hsa041101.74602521
36Huntingtons disease_Homo sapiens_hsa050161.64590822
37Serotonergic synapse_Homo sapiens_hsa047261.63599942
38Olfactory transduction_Homo sapiens_hsa047401.60071557
39Spliceosome_Homo sapiens_hsa030401.58707236
40One carbon pool by folate_Homo sapiens_hsa006701.55201701
41Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.51136081
42Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.49367019
43Phagosome_Homo sapiens_hsa041451.49227397
44Pyrimidine metabolism_Homo sapiens_hsa002401.44435296
45Dopaminergic synapse_Homo sapiens_hsa047281.43066408
46Selenocompound metabolism_Homo sapiens_hsa004501.37538415
47Sulfur metabolism_Homo sapiens_hsa009201.34266675
48Amphetamine addiction_Homo sapiens_hsa050311.34027952
49Cysteine and methionine metabolism_Homo sapiens_hsa002701.31637459
50Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.29492461
51Purine metabolism_Homo sapiens_hsa002301.24719584
52Long-term potentiation_Homo sapiens_hsa047201.22574779
53Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.20674651
54Long-term depression_Homo sapiens_hsa047301.19600416
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.17550188
56Oocyte meiosis_Homo sapiens_hsa041141.16138724
57Taste transduction_Homo sapiens_hsa047421.15787800
58Phototransduction_Homo sapiens_hsa047441.15515199
59Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.14183215
60Cardiac muscle contraction_Homo sapiens_hsa042601.14160361
61Cocaine addiction_Homo sapiens_hsa050301.10835650
62Ether lipid metabolism_Homo sapiens_hsa005651.09666530
63Butanoate metabolism_Homo sapiens_hsa006501.08636997
64Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.08341769
65Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.07174486
66Insulin secretion_Homo sapiens_hsa049111.04356637
67Salivary secretion_Homo sapiens_hsa049701.01515887
68Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.01158445
69Sphingolipid metabolism_Homo sapiens_hsa006001.01128872
70Folate biosynthesis_Homo sapiens_hsa007900.99547394
71mRNA surveillance pathway_Homo sapiens_hsa030150.96501866
72Type I diabetes mellitus_Homo sapiens_hsa049400.95872031
73Cholinergic synapse_Homo sapiens_hsa047250.94424087
74Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.92712282
75p53 signaling pathway_Homo sapiens_hsa041150.92490686
76Renin secretion_Homo sapiens_hsa049240.90000387
77Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.89666585
78Lysosome_Homo sapiens_hsa041420.89181666
79Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.81329265
80Axon guidance_Homo sapiens_hsa043600.80374431
81Alcoholism_Homo sapiens_hsa050340.75856158
82Proteasome_Homo sapiens_hsa030500.75826710
83Gastric acid secretion_Homo sapiens_hsa049710.75046636
84Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.72768209
85Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.72578858
86Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.71242228
87Histidine metabolism_Homo sapiens_hsa003400.68572307
88Fatty acid metabolism_Homo sapiens_hsa012120.67608595
89Calcium signaling pathway_Homo sapiens_hsa040200.66299517
90Nitrogen metabolism_Homo sapiens_hsa009100.63505362
91Regulation of autophagy_Homo sapiens_hsa041400.63043393
92Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.61958243
93Aldosterone synthesis and secretion_Homo sapiens_hsa049250.61724370
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59240018
95Glutathione metabolism_Homo sapiens_hsa004800.58022750
96Oxytocin signaling pathway_Homo sapiens_hsa049210.57479382
97Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.57114213
98beta-Alanine metabolism_Homo sapiens_hsa004100.56537560
99Ribosome_Homo sapiens_hsa030100.54986993
100Circadian rhythm_Homo sapiens_hsa047100.54918959
101Peroxisome_Homo sapiens_hsa041460.54232147
102Primary bile acid biosynthesis_Homo sapiens_hsa001200.54064918
103Propanoate metabolism_Homo sapiens_hsa006400.53849602
104Vitamin B6 metabolism_Homo sapiens_hsa007500.52698208
105Hippo signaling pathway_Homo sapiens_hsa043900.51925348
106Pyruvate metabolism_Homo sapiens_hsa006200.50387778
107Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.50215488
108Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.49894635
109Carbon metabolism_Homo sapiens_hsa012000.47725341
110Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.47058341
111Biosynthesis of amino acids_Homo sapiens_hsa012300.46956868
1122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.46920070
113Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.46460516
114Gap junction_Homo sapiens_hsa045400.46395308
115Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.45628907
116Other glycan degradation_Homo sapiens_hsa005110.45361631
117Pancreatic secretion_Homo sapiens_hsa049720.44595966
118Systemic lupus erythematosus_Homo sapiens_hsa053220.43983505
119Hedgehog signaling pathway_Homo sapiens_hsa043400.41104905
120Metabolic pathways_Homo sapiens_hsa011000.40963371
121Vascular smooth muscle contraction_Homo sapiens_hsa042700.40373653
122African trypanosomiasis_Homo sapiens_hsa051430.40021116
123Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.39521046
124TGF-beta signaling pathway_Homo sapiens_hsa043500.38844927
125Pertussis_Homo sapiens_hsa051330.38790348
126Prion diseases_Homo sapiens_hsa050200.37438953
127Graft-versus-host disease_Homo sapiens_hsa053320.36895180
128Tryptophan metabolism_Homo sapiens_hsa003800.36218653
129cAMP signaling pathway_Homo sapiens_hsa040240.34530561
130Maturity onset diabetes of the young_Homo sapiens_hsa049500.33823459
131Tyrosine metabolism_Homo sapiens_hsa003500.33350183
132Wnt signaling pathway_Homo sapiens_hsa043100.32738988
133Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.32568441
134Steroid hormone biosynthesis_Homo sapiens_hsa001400.32544946
135Sphingolipid signaling pathway_Homo sapiens_hsa040710.31429592
136Ovarian steroidogenesis_Homo sapiens_hsa049130.30976628
137Thyroid hormone synthesis_Homo sapiens_hsa049180.30599827
138Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.30080719
139N-Glycan biosynthesis_Homo sapiens_hsa005100.29584392
140GnRH signaling pathway_Homo sapiens_hsa049120.28694551
141Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.27225433
142Ras signaling pathway_Homo sapiens_hsa040140.26786779
143Autoimmune thyroid disease_Homo sapiens_hsa053200.25667133
144Lysine degradation_Homo sapiens_hsa003100.25003972
145Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.24929320
146Arginine and proline metabolism_Homo sapiens_hsa003300.24795369
147Allograft rejection_Homo sapiens_hsa053300.24303355
148Phenylalanine metabolism_Homo sapiens_hsa003600.24237585
149Malaria_Homo sapiens_hsa051440.23719789
150Basal cell carcinoma_Homo sapiens_hsa052170.23651523
151Salmonella infection_Homo sapiens_hsa051320.22563071

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