VMAC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)9.71506438
2Golgi transport vesicle coating (GO:0048200)9.71506438
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)7.35462649
4endocrine pancreas development (GO:0031018)6.90636547
5protein retention in ER lumen (GO:0006621)6.62686580
6signal peptide processing (GO:0006465)6.23670028
7protein maturation by protein folding (GO:0022417)5.72589490
8retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)5.70224025
9COPII vesicle coating (GO:0048208)5.66210299
10glandular epithelial cell differentiation (GO:0002067)5.26301003
11activation of signaling protein activity involved in unfolded protein response (GO:0006987)5.25026601
12peptide hormone processing (GO:0016486)4.99992807
13GDP-mannose metabolic process (GO:0019673)4.98040537
14positive regulation of nuclease activity (GO:0032075)4.97729330
15ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)4.96321088
16exocrine pancreas development (GO:0031017)4.89633489
17regulation of type B pancreatic cell apoptotic process (GO:2000674)4.75782357
18fucose catabolic process (GO:0019317)4.62876627
19L-fucose metabolic process (GO:0042354)4.62876627
20L-fucose catabolic process (GO:0042355)4.62876627
21regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022354.61099485
22endoplasmic reticulum unfolded protein response (GO:0030968)4.53030678
23regulation of nuclease activity (GO:0032069)4.49298510
24cellular response to unfolded protein (GO:0034620)4.47022801
25cellular response to topologically incorrect protein (GO:0035967)4.32961645
26epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.24829890
27positive regulation of insulin secretion (GO:0032024)4.24289465
28ER-nucleus signaling pathway (GO:0006984)4.21577059
29L-phenylalanine catabolic process (GO:0006559)4.21011691
30erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.21011691
31sequestering of metal ion (GO:0051238)4.18250952
32type B pancreatic cell development (GO:0003323)4.17668724
33behavioral response to nicotine (GO:0035095)4.15685653
34glandular epithelial cell development (GO:0002068)4.13161357
35vesicle coating (GO:0006901)4.11879704
36ER overload response (GO:0006983)4.04120570
37L-phenylalanine metabolic process (GO:0006558)3.98801920
38erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.98801920
39negative regulation of glycoprotein biosynthetic process (GO:0010561)3.97585277
40protein N-linked glycosylation via asparagine (GO:0018279)3.94935834
41peptidyl-asparagine modification (GO:0018196)3.92608623
42DNA deamination (GO:0045006)3.90770859
43activated T cell proliferation (GO:0050798)3.86909697
44response to endoplasmic reticulum stress (GO:0034976)3.70811360
45protein N-linked glycosylation (GO:0006487)3.61148643
46detection of light stimulus involved in sensory perception (GO:0050962)3.48720726
47detection of light stimulus involved in visual perception (GO:0050908)3.48720726
48insulin secretion (GO:0030073)3.48164560
49positive regulation of defense response to virus by host (GO:0002230)3.47721066
50ER to Golgi vesicle-mediated transport (GO:0006888)3.46580582
51response to unfolded protein (GO:0006986)3.46249009
52negative regulation of mast cell activation (GO:0033004)3.44999264
53toxin metabolic process (GO:0009404)3.43891118
54regulation of insulin secretion (GO:0050796)3.43227204
55positive regulation of peptide hormone secretion (GO:0090277)3.43066839
56proline biosynthetic process (GO:0006561)3.42682423
57pteridine-containing compound biosynthetic process (GO:0042559)3.40503737
58response to topologically incorrect protein (GO:0035966)3.38374700
59columnar/cuboidal epithelial cell development (GO:0002066)3.32764652
60purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.31560940
613-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.31560940
624-hydroxyproline metabolic process (GO:0019471)3.31479848
63cellular ketone body metabolic process (GO:0046950)3.28111260
64positive regulation of peptide secretion (GO:0002793)3.26554371
65negative regulation of telomere maintenance (GO:0032205)3.25026133
66tolerance induction (GO:0002507)3.24751384
67interferon-gamma production (GO:0032609)3.23777785
68regulation of B cell receptor signaling pathway (GO:0050855)3.22698226
69detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)3.18379420
70regulation of peptide hormone secretion (GO:0090276)3.14750312
71negative T cell selection (GO:0043383)3.14382358
72negative thymic T cell selection (GO:0045060)3.14257516
73negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.13834054
74negative regulation of cell killing (GO:0031342)3.13834054
75cellular response to vitamin D (GO:0071305)3.12613233
76platelet dense granule organization (GO:0060155)3.12611351
77response to pheromone (GO:0019236)3.12057661
78regulation of hexokinase activity (GO:1903299)3.11813659
79regulation of glucokinase activity (GO:0033131)3.11813659
80regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.11515960
81antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.11055361
82protein K11-linked deubiquitination (GO:0035871)3.10597637
83positive regulation of gamma-delta T cell activation (GO:0046645)3.09126300
84regulation of peptide secretion (GO:0002791)3.06911855
85negative regulation of glycogen biosynthetic process (GO:0045719)3.06818667
86tryptophan catabolic process (GO:0006569)3.05209579
87indole-containing compound catabolic process (GO:0042436)3.05209579
88indolalkylamine catabolic process (GO:0046218)3.05209579
89nucleoside diphosphate catabolic process (GO:0009134)3.04336479
90negative regulation of glycoprotein metabolic process (GO:1903019)3.03020412
91regulation of memory T cell differentiation (GO:0043380)2.98516622
92rRNA catabolic process (GO:0016075)2.98056361
93preassembly of GPI anchor in ER membrane (GO:0016254)2.94993927
94intestinal cholesterol absorption (GO:0030299)2.94666265
95tricarboxylic acid metabolic process (GO:0072350)2.94148966
96response to hexose (GO:0009746)2.93327915
97production of molecular mediator involved in inflammatory response (GO:0002532)2.93024262
98epithelial cilium movement (GO:0003351)2.92878455
99nucleotide-sugar metabolic process (GO:0009225)2.92415113
100cellular response to interleukin-15 (GO:0071350)2.92052983
101cytidine deamination (GO:0009972)2.91541501
102cytidine metabolic process (GO:0046087)2.91541501
103cytidine catabolic process (GO:0006216)2.91541501
104response to glucose (GO:0009749)2.90124737
105ketone body metabolic process (GO:1902224)2.89563601
106cilium or flagellum-dependent cell motility (GO:0001539)2.87332605
107axoneme assembly (GO:0035082)2.85732675
108folic acid-containing compound biosynthetic process (GO:0009396)2.84428742
109regulation of T cell mediated cytotoxicity (GO:0001914)2.84096254
110positive T cell selection (GO:0043368)2.84039416
111indolalkylamine metabolic process (GO:0006586)2.82416026
112positive regulation of T cell mediated cytotoxicity (GO:0001916)2.82045038
113biotin metabolic process (GO:0006768)2.81869048
114valine metabolic process (GO:0006573)2.81453570
115cellular response to exogenous dsRNA (GO:0071360)2.81292536
116nucleotide-sugar biosynthetic process (GO:0009226)2.79726400
117regulation of gamma-delta T cell activation (GO:0046643)2.79612992
118response to monosaccharide (GO:0034284)2.78556098
119regulation of cilium movement (GO:0003352)2.78373746
120regulation of gamma-delta T cell differentiation (GO:0045586)2.78259728
121negative regulation of T cell mediated immunity (GO:0002710)2.77364714
122magnesium ion transport (GO:0015693)2.77205636
123epithelial cell fate commitment (GO:0072148)2.75273974
124Golgi organization (GO:0007030)2.74112120
125ribonucleoside bisphosphate metabolic process (GO:0033875)2.73604927
126nucleoside bisphosphate metabolic process (GO:0033865)2.73604927
127purine nucleoside bisphosphate metabolic process (GO:0034032)2.73604927
128positive thymic T cell selection (GO:0045059)2.72950678
129regulation of glucocorticoid secretion (GO:2000849)2.72811807
130neural tube formation (GO:0001841)2.72592509
131multicellular organism reproduction (GO:0032504)2.72471329
132pyrimidine ribonucleoside catabolic process (GO:0046133)2.72402602
133intestinal absorption (GO:0050892)2.71531128
134negative regulation of interleukin-1 production (GO:0032692)2.70802668
135kynurenine metabolic process (GO:0070189)2.69272846
136negative regulation of interleukin-1 beta production (GO:0032691)2.69212390
137positive regulation of granulocyte differentiation (GO:0030854)2.68987812
138granulocyte differentiation (GO:0030851)2.68949248
139positive regulation of glycolytic process (GO:0045821)2.68309018
140regulation of hormone secretion (GO:0046883)2.68242929
141negative regulation of cAMP-mediated signaling (GO:0043951)2.68232303
142tryptophan metabolic process (GO:0006568)2.68047438
143glucose homeostasis (GO:0042593)2.67968510
144carbohydrate homeostasis (GO:0033500)2.67968510
145positive regulation of hormone biosynthetic process (GO:0046886)2.66889503
146positive regulation of hormone secretion (GO:0046887)2.66782381
147piRNA metabolic process (GO:0034587)2.66503798
148sensory perception of taste (GO:0050909)2.66474852
149fucosylation (GO:0036065)2.66111364
150regulation of germinal center formation (GO:0002634)2.65841097
151cellular response to antibiotic (GO:0071236)2.65235440
152regulation of defense response to virus by host (GO:0050691)2.63866147
153nitric oxide mediated signal transduction (GO:0007263)2.63650743
154positive regulation of fatty acid beta-oxidation (GO:0032000)2.63638929
155maintenance of protein localization in organelle (GO:0072595)2.63434222
156organelle membrane fusion (GO:0090174)2.63280689
157peptide metabolic process (GO:0006518)2.61920330
158purinergic nucleotide receptor signaling pathway (GO:0035590)2.61719758
159response to interleukin-15 (GO:0070672)2.61451570
160L-alpha-amino acid transmembrane transport (GO:1902475)2.61357366
161cellular zinc ion homeostasis (GO:0006882)2.60088492
162negative regulation of insulin secretion (GO:0046676)2.58505980
163eye photoreceptor cell differentiation (GO:0001754)2.58389137
164photoreceptor cell differentiation (GO:0046530)2.58389137
165branched-chain amino acid metabolic process (GO:0009081)2.57822297
166cilium movement (GO:0003341)2.52230804
167inositol phosphate catabolic process (GO:0071545)2.50945293
168positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.49742254
169negative regulation of calcium ion transport into cytosol (GO:0010523)2.49083916
170T cell selection (GO:0045058)2.48532990
171protein polyglutamylation (GO:0018095)2.48116398
172mannosylation (GO:0097502)2.47392954
173mast cell degranulation (GO:0043303)2.46812391
174mast cell activation involved in immune response (GO:0002279)2.46812391
175regulation of regulatory T cell differentiation (GO:0045589)2.46690000
176mast cell activation (GO:0045576)2.45874664
177regulation of action potential (GO:0098900)2.45837168
178adaptation of signaling pathway (GO:0023058)2.45401480
179establishment of protein localization to Golgi (GO:0072600)2.45336686
180NAD biosynthetic process (GO:0009435)2.44499053
181neuronal action potential (GO:0019228)2.43728287
182phosphorylated carbohydrate dephosphorylation (GO:0046838)2.43207323
183inositol phosphate dephosphorylation (GO:0046855)2.43207323
184regulation of interleukin-6 biosynthetic process (GO:0045408)2.41981737
185polyol catabolic process (GO:0046174)2.41722899
186regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.40014083
187DNA methylation involved in gamete generation (GO:0043046)2.35427950
188cellular response to interferon-beta (GO:0035458)2.34669816
189positive regulation of fatty acid transport (GO:2000193)2.33298040
190positive regulation of calcium-mediated signaling (GO:0050850)2.33030851
191positive regulation of B cell differentiation (GO:0045579)2.31591021
192negative regulation of lymphocyte mediated immunity (GO:0002707)2.31447310
193regulation of MHC class I biosynthetic process (GO:0045343)2.31104036
194regulation of interleukin-12 biosynthetic process (GO:0045075)2.30377918
195detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.28973112
196regulation of B cell differentiation (GO:0045577)2.27853263
197adenosine metabolic process (GO:0046085)2.26853911
198phosphatidylinositol acyl-chain remodeling (GO:0036149)2.26078168

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.01802172
2DMRT1_21621532_ChIP-ChIP_FETAL_Ovary4.60554679
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.97972165
4ZNF274_21170338_ChIP-Seq_K562_Hela3.68792414
5RXR_22158963_ChIP-Seq_LIVER_Mouse3.47904100
6GATA1_22025678_ChIP-Seq_K562_Human3.16600377
7PDX1_19855005_ChIP-ChIP_MIN6_Mouse3.05959326
8PPARA_22158963_ChIP-Seq_LIVER_Mouse3.02064426
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.99126239
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.98447790
11EZH2_22144423_ChIP-Seq_EOC_Human2.81764095
12LXR_22158963_ChIP-Seq_LIVER_Mouse2.80295457
13VDR_22108803_ChIP-Seq_LS180_Human2.75862855
14FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.49624963
15CLOCK_20551151_ChIP-Seq_293T_Human2.36625700
16CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.36394228
17SOX2_27498859_Chip-Seq_STOMACH_Mouse2.32571699
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.31006411
19NOTCH1_21737748_ChIP-Seq_TLL_Human2.18629870
20IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.05213535
21IGF1R_20145208_ChIP-Seq_DFB_Human2.03019882
22GBX2_23144817_ChIP-Seq_PC3_Human2.00397291
23RUNX_20019798_ChIP-Seq_JUKART_Human1.87167263
24TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.84473872
25FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.82905034
26FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.82123790
27ER_23166858_ChIP-Seq_MCF-7_Human1.81052691
28FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.78943384
29FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.78917667
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.77791836
31NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.77322151
32FLI1_27457419_Chip-Seq_LIVER_Mouse1.77043862
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.74475960
34EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.73648804
35CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.73588765
36ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.72555878
37CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.69707188
38TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.66229110
39TFEB_21752829_ChIP-Seq_HELA_Human1.61119862
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.58199483
41LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.56871300
42GATA3_26560356_Chip-Seq_TH2_Human1.56273000
43PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.56111946
44IRF8_21731497_ChIP-ChIP_J774_Mouse1.55663412
45PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.55543805
46SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.48104842
47CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.47969617
48TP53_22573176_ChIP-Seq_HFKS_Human1.47390926
49DROSHA_22980978_ChIP-Seq_HELA_Human1.47180703
50GATA3_21878914_ChIP-Seq_MCF-7_Human1.47076255
51IRF1_19129219_ChIP-ChIP_H3396_Human1.46817306
52PCGF2_27294783_Chip-Seq_ESCs_Mouse1.45487458
53STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.45185494
54GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.43705816
55ERA_21632823_ChIP-Seq_H3396_Human1.43616618
56BCAT_22108803_ChIP-Seq_LS180_Human1.43085424
57PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.41113310
58BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.39400726
59NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.38731896
60EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.38033290
61MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.34543470
62ESR1_21235772_ChIP-Seq_MCF-7_Human1.33910392
63ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.33796998
64ZFX_18555785_ChIP-Seq_MESCs_Mouse1.33597503
65EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.32580570
66HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.32521653
67ETV2_25802403_ChIP-Seq_MESCs_Mouse1.32187650
68IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.31588768
69GATA4_25053715_ChIP-Seq_YYC3_Human1.31347791
70PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.31175154
71MYB_26560356_Chip-Seq_TH2_Human1.30632524
72CTBP2_25329375_ChIP-Seq_LNCAP_Human1.30285574
73POU3F2_20337985_ChIP-ChIP_501MEL_Human1.29721245
74EGR1_23403033_ChIP-Seq_LIVER_Mouse1.28911509
75OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.28284725
76CHD1_26751641_Chip-Seq_LNCaP_Human1.28015998
77SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.26761137
78AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.26457050
79FOXA1_25329375_ChIP-Seq_VCAP_Human1.26045248
80FOXA1_27270436_Chip-Seq_PROSTATE_Human1.26045248
81NFIB_24661679_ChIP-Seq_LUNG_Mouse1.25512491
82PCGF2_27294783_Chip-Seq_NPCs_Mouse1.25271878
83CIITA_25753668_ChIP-Seq_RAJI_Human1.25200408
84ERG_20887958_ChIP-Seq_HPC-7_Mouse1.25031335
85RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.22566853
86HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.22516775
87MYC_22102868_ChIP-Seq_BL_Human1.20918681
88LXR_22292898_ChIP-Seq_THP-1_Human1.20210657
89TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19658266
90SMRT_27268052_Chip-Seq_Bcells_Human1.19656383
91JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.19222701
92CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.18542511
93GABP_17652178_ChIP-ChIP_JURKAT_Human1.18386725
94TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.18246076
95IKZF1_21737484_ChIP-ChIP_HCT116_Human1.17997678
96SOX2_19829295_ChIP-Seq_ESCs_Human1.17879567
97NANOG_19829295_ChIP-Seq_ESCs_Human1.17879567
98GATA3_27048872_Chip-Seq_THYMUS_Human1.17495055
99TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.17290106
100HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.16920368
101NANOG_20526341_ChIP-Seq_ESCs_Human1.16865309
102EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.15397298
103GATA3_24758297_ChIP-Seq_MCF-7_Human1.14995092
104VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.14562420
105NCOR_22424771_ChIP-Seq_293T_Human1.14367849
106RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.14106968
107PRDM14_20953172_ChIP-Seq_ESCs_Human1.14041591
108NR3C1_21868756_ChIP-Seq_MCF10A_Human1.13091559
109STAT3_23295773_ChIP-Seq_U87_Human1.12871366
110MYC_19829295_ChIP-Seq_ESCs_Human1.12655422
111TCF4_23295773_ChIP-Seq_U87_Human1.12539377
112PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.11685883
113MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.11413906
114SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.10947955
115HOXB7_26014856_ChIP-Seq_BT474_Human1.10904011
116ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.10772157
117P300_19829295_ChIP-Seq_ESCs_Human1.10765943
118RARB_24833708_ChIP-Seq_LIVER_Mouse1.10507843
119SCL_19346495_ChIP-Seq_HPC-7_Human1.10387162
120TAF2_19829295_ChIP-Seq_ESCs_Human1.10212326
121FOXA1_21572438_ChIP-Seq_LNCaP_Human1.10178618
122TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.09666650
123BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.09585671
124* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.09382985
125TAF15_26573619_Chip-Seq_HEK293_Human1.09230893
126AR_25329375_ChIP-Seq_VCAP_Human1.08854015
127POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.08735349
128TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08735349
129MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.08730132
130IRF8_22096565_ChIP-ChIP_GC-B_Human1.06962356
131VDR_24787735_ChIP-Seq_THP-1_Human1.06891625
132SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.05907792
133RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.05838929
134AR_21572438_ChIP-Seq_LNCaP_Human1.04650175
135BCL6_27268052_Chip-Seq_Bcells_Human1.04392959
136RACK7_27058665_Chip-Seq_MCF-7_Human1.04291357
137EWS_26573619_Chip-Seq_HEK293_Human1.04132709
138MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.04120600
139VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.04031350
140CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.03888656
141TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.03213284
142GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.02389084
143RUNX1_27514584_Chip-Seq_MCF-7_Human1.02322881
144OCT4_20526341_ChIP-Seq_ESCs_Human1.01994521
145* TET1_21451524_ChIP-Seq_MESCs_Mouse1.01673590
146STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.01349163
147REST_21632747_ChIP-Seq_MESCs_Mouse1.01172781
148RAC3_21632823_ChIP-Seq_H3396_Human1.00089376
149UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00072736
150TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.99878836
151SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.99356991
152SOX2_20726797_ChIP-Seq_SW620_Human0.99337921
153VDR_23849224_ChIP-Seq_CD4+_Human0.99033807
154CEBPB_22108803_ChIP-Seq_LS180_Human0.98282210
155P300_27268052_Chip-Seq_Bcells_Human0.97835833
156IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.97683465
157CBP_20019798_ChIP-Seq_JUKART_Human0.97683465
158SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.97622105
159IRF8_27001747_Chip-Seq_BMDM_Mouse0.97226209
160SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.97056874
161FOXH1_21741376_ChIP-Seq_ESCs_Human0.96773684
162AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.96374563
163FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.96342548
164TRIM28_21343339_ChIP-Seq_HEK293_Human0.95299632
165EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.94742197
166GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.94206810
167* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.94112725
168CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.93091680
169GATA3_26560356_Chip-Seq_TH1_Human0.92934942
170* ERG_20517297_ChIP-Seq_VCAP_Human0.92582911
171FOXH1_21741376_ChIP-Seq_EPCs_Human0.92564810
172NFE2_27457419_Chip-Seq_LIVER_Mouse0.92429178
173DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.92328404
174AR_20517297_ChIP-Seq_VCAP_Human0.92064303
175SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.91839652
176GABP_19822575_ChIP-Seq_HepG2_Human0.91048450
177LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.90984224
178SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.90675653
179SUZ12_27294783_Chip-Seq_NPCs_Mouse0.90310390
180RUNX2_22187159_ChIP-Seq_PCA_Human0.90164215
181E2F1_18555785_ChIP-Seq_MESCs_Mouse0.88894835
182TBX5_21415370_ChIP-Seq_HL-1_Mouse0.88857174
183ELF1_17652178_ChIP-ChIP_JURKAT_Human0.88327509
184PKCTHETA_26484144_Chip-Seq_BREAST_Human0.88252587
185TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.88234806
186FOXA2_19822575_ChIP-Seq_HepG2_Human0.86773620
187FOXA1_25552417_ChIP-Seq_VCAP_Human0.85042431
188ATF3_27146783_Chip-Seq_COLON_Human0.84786901
189CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.81932661
190SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.81820182
191ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.81026535
192PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.80966862
193ESR2_21235772_ChIP-Seq_MCF-7_Human0.79623368
194* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.79332868
195PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.78421009

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002877_abnormal_melanocyte_morpholog4.95589682
2MP0001986_abnormal_taste_sensitivity4.39070144
3MP0004043_abnormal_pH_regulation3.93019597
4MP0002139_abnormal_hepatobiliary_system3.66160461
5MP0003283_abnormal_digestive_organ3.63851692
6MP0010386_abnormal_urinary_bladder3.57108290
7MP0000013_abnormal_adipose_tissue3.54723804
8MP0002693_abnormal_pancreas_physiology3.43291408
9MP0003195_calcinosis3.41481690
10MP0001944_abnormal_pancreas_morphology3.35058687
11MP0005365_abnormal_bile_salt3.19981739
12MP0005220_abnormal_exocrine_pancreas3.18237154
13MP0003183_abnormal_peptide_metabolism3.08528640
14MP0009780_abnormal_chondrocyte_physiolo2.74380401
15MP0005671_abnormal_response_to2.72964599
16MP0002909_abnormal_adrenal_gland2.66940618
17MP0004264_abnormal_extraembryonic_tissu2.56492451
18MP0000678_abnormal_parathyroid_gland2.46838843
19MP0001835_abnormal_antigen_presentation2.31194830
20MP0005379_endocrine/exocrine_gland_phen2.26569526
21MP0001666_abnormal_nutrient_absorption2.22390472
22MP0001968_abnormal_touch/_nociception2.17392284
23MP0001800_abnormal_humoral_immune2.17133752
24MP0003763_abnormal_thymus_physiology2.15682665
25MP0003646_muscle_fatigue2.09500438
26MP0002078_abnormal_glucose_homeostasis2.03747161
27MP0000685_abnormal_immune_system2.03527806
28MP0003011_delayed_dark_adaptation2.02631046
29MP0003724_increased_susceptibility_to2.02084067
30MP0006072_abnormal_retinal_apoptosis2.00157805
31MP0005551_abnormal_eye_electrophysiolog1.96563864
32MP0000003_abnormal_adipose_tissue1.93204026
33MP0003252_abnormal_bile_duct1.91127008
34MP0002736_abnormal_nociception_after1.90083299
35MP0001873_stomach_inflammation1.89630234
36MP0003868_abnormal_feces_composition1.89424288
37MP0005058_abnormal_lysosome_morphology1.88947151
38MP0002837_dystrophic_cardiac_calcinosis1.88517742
39MP0003300_gastrointestinal_ulcer1.88039612
40MP0002928_abnormal_bile_duct1.86808265
41MP0009643_abnormal_urine_homeostasis1.86087302
42MP0000569_abnormal_digit_pigmentation1.82211857
43MP0005387_immune_system_phenotype1.79848264
44MP0001790_abnormal_immune_system1.79848264
45MP0002723_abnormal_immune_serum1.73213102
46MP0005085_abnormal_gallbladder_physiolo1.72690833
47MP0003436_decreased_susceptibility_to1.70302095
48MP0002138_abnormal_hepatobiliary_system1.68842918
49MP0002102_abnormal_ear_morphology1.67280038
50MP0000538_abnormal_urinary_bladder1.64389430
51MP0002452_abnormal_antigen_presenting1.62820457
52MP0002420_abnormal_adaptive_immunity1.60987415
53MP0001819_abnormal_immune_cell1.59210520
54MP0008872_abnormal_physiological_respon1.59075951
55MP0005075_abnormal_melanosome_morpholog1.57610300
56MP0008877_abnormal_DNA_methylation1.57039932
57MP0005000_abnormal_immune_tolerance1.54076704
58MP0009785_altered_susceptibility_to1.53464674
59MP0005084_abnormal_gallbladder_morpholo1.50291232
60MP0002277_abnormal_respiratory_mucosa1.49119492
61MP0000462_abnormal_digestive_system1.47817738
62MP0001270_distended_abdomen1.47559463
63MP0005174_abnormal_tail_pigmentation1.45011878
64MP0009764_decreased_sensitivity_to1.44126454
65MP0004142_abnormal_muscle_tone1.43053069
66MP0001501_abnormal_sleep_pattern1.41773140
67MP0002148_abnormal_hypersensitivity_rea1.40440823
68MP0005025_abnormal_response_to1.40299948
69MP0005410_abnormal_fertilization1.36121319
70MP0002419_abnormal_innate_immunity1.33353888
71MP0010234_abnormal_vibrissa_follicle1.32967429
72MP0000613_abnormal_salivary_gland1.31082354
73MP0001765_abnormal_ion_homeostasis1.30996313
74MP0010329_abnormal_lipoprotein_level1.29049599
75MP0003878_abnormal_ear_physiology1.28758590
76MP0005377_hearing/vestibular/ear_phenot1.28758590
77MP0009046_muscle_twitch1.28329128
78MP0002405_respiratory_system_inflammati1.27601234
79MP0004381_abnormal_hair_follicle1.25123081
80MP0002638_abnormal_pupillary_reflex1.24856329
81MP0002118_abnormal_lipid_homeostasis1.24300410
82MP0003806_abnormal_nucleotide_metabolis1.22900397
83MP0003953_abnormal_hormone_level1.22568594
84MP0005375_adipose_tissue_phenotype1.20295680
85MP0000015_abnormal_ear_pigmentation1.19392152
86MP0005083_abnormal_biliary_tract1.18876304
87MP0000716_abnormal_immune_system1.18767644
88MP0005257_abnormal_intraocular_pressure1.18701683
89MP0008875_abnormal_xenobiotic_pharmacok1.17246886
90MP0003172_abnormal_lysosome_physiology1.17131313
91MP0009745_abnormal_behavioral_response1.16963505
92MP0000427_abnormal_hair_cycle1.15732497
93MP0000689_abnormal_spleen_morphology1.15081554
94MP0002896_abnormal_bone_mineralization1.14222070
95MP0005408_hypopigmentation1.14133957
96MP0001756_abnormal_urination1.12945833
97MP0002398_abnormal_bone_marrow1.12500264
98MP0005167_abnormal_blood-brain_barrier1.11353438
99MP0009840_abnormal_foam_cell1.10947442
100MP0006082_CNS_inflammation1.09460322
101MP0006292_abnormal_olfactory_placode1.08472363
102MP0008995_early_reproductive_senescence1.06652807
103MP0001764_abnormal_homeostasis1.05287555
104MP0001486_abnormal_startle_reflex1.04127292
105MP0005636_abnormal_mineral_homeostasis1.03443497
106MP0003787_abnormal_imprinting1.02165480
107MP0005389_reproductive_system_phenotype1.02027858
108MP0009278_abnormal_bone_marrow1.00490809
109MP0000703_abnormal_thymus_morphology1.00409726
110MP0002735_abnormal_chemical_nociception0.98029423
111MP0000681_abnormal_thyroid_gland0.97596180
112MP0008961_abnormal_basal_metabolism0.97263406
113MP0000470_abnormal_stomach_morphology0.97112447
114MP0001845_abnormal_inflammatory_respons0.96073059
115MP0000609_abnormal_liver_physiology0.95833513
116MP0001664_abnormal_digestion0.95831475
117MP0005666_abnormal_adipose_tissue0.95725774
118MP0002722_abnormal_immune_system0.94912105
119MP0005360_urolithiasis0.94110914
120MP0006054_spinal_hemorrhage0.93880981
121MP0010155_abnormal_intestine_physiology0.90912656
122MP0005332_abnormal_amino_acid0.88144173
123MP0005310_abnormal_salivary_gland0.87981592
124MP0001849_ear_inflammation0.86981785
125MP0000230_abnormal_systemic_arterial0.86884086
126MP0001984_abnormal_olfaction0.85497537
127MP0004130_abnormal_muscle_cell0.85461930
128MP0003045_fibrosis0.84911253
129MP0009333_abnormal_splenocyte_physiolog0.84561411
130MP0002429_abnormal_blood_cell0.83326071
131MP0008469_abnormal_protein_level0.82666953
132MP0000372_irregular_coat_pigmentation0.82648827
133MP0002168_other_aberrant_phenotype0.80512624
134MP0002295_abnormal_pulmonary_circulatio0.80296950
135MP0001905_abnormal_dopamine_level0.79978105
136MP0005464_abnormal_platelet_physiology0.79516605
137MP0005670_abnormal_white_adipose0.79300300
138MP0002272_abnormal_nervous_system0.79012927
139MP0001663_abnormal_digestive_system0.78185809
140MP0002733_abnormal_thermal_nociception0.77587819
141MP0005645_abnormal_hypothalamus_physiol0.75114688
142MP0003959_abnormal_lean_body0.73666847
143MP0008004_abnormal_stomach_pH0.70259272
144MP0000631_abnormal_neuroendocrine_gland0.70040009
145MP0002653_abnormal_ependyma_morphology0.69126562
146MP0003119_abnormal_digestive_system0.68835315
147MP0005535_abnormal_body_temperature0.68161884
148MP0004133_heterotaxia0.67901965
149MP0009642_abnormal_blood_homeostasis0.67234003
150MP0003866_abnormal_defecation0.66884562
151MP0004019_abnormal_vitamin_homeostasis0.65930497
152MP0003186_abnormal_redox_activity0.64602520
153MP0001661_extended_life_span0.64410258
154MP0004272_abnormal_basement_membrane0.63975096
155MP0005334_abnormal_fat_pad0.63854420
156MP0000639_abnormal_adrenal_gland0.63515285
157MP0002234_abnormal_pharynx_morphology0.63385808
158MP0003191_abnormal_cellular_cholesterol0.62366685
159MP0005448_abnormal_energy_balance0.61104858
160MP0002876_abnormal_thyroid_physiology0.59759424
161MP0000163_abnormal_cartilage_morphology0.59607005
162MP0005319_abnormal_enzyme/_coenzyme0.59576198
163MP0000534_abnormal_ureter_morphology0.57442679
164MP0005646_abnormal_pituitary_gland0.56741918
165MP0001919_abnormal_reproductive_system0.56631416
166MP0003795_abnormal_bone_structure0.54788096
167MP0000490_abnormal_crypts_of0.54340717
168MP0005395_other_phenotype0.53947347
169MP0003638_abnormal_response/metabolism_0.53681938
170MP0002009_preneoplasia0.52926270
171MP0010368_abnormal_lymphatic_system0.52773880
172MP0005253_abnormal_eye_physiology0.52590869
173MP0002163_abnormal_gland_morphology0.50838467
174MP0000598_abnormal_liver_morphology0.50637874

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic seizures (HP:0002173)6.38261052
2Hyperinsulinemic hypoglycemia (HP:0000825)6.31424317
3Hypoglycemic coma (HP:0001325)5.85278516
4Symptomatic seizures (HP:0011145)5.34372574
5Ketoacidosis (HP:0001993)5.26936403
6Abnormality of the intrinsic pathway (HP:0010989)5.07715836
7Abnormality of aromatic amino acid family metabolism (HP:0004338)4.68367596
8Elevated circulating parathyroid hormone (PTH) level (HP:0003165)4.66774723
9Late onset (HP:0003584)4.31694138
10Congenital stationary night blindness (HP:0007642)4.31452341
11Dysostosis multiplex (HP:0000943)4.23442894
12Abnormality of the pancreatic islet cells (HP:0006476)4.16953188
13Abnormality of endocrine pancreas physiology (HP:0012093)4.16953188
14Pancreatic cysts (HP:0001737)4.08053604
15Hyperglycemia (HP:0003074)3.99379236
16Stomatitis (HP:0010280)3.87174232
17Mucopolysacchariduria (HP:0008155)3.86687218
18Urinary glycosaminoglycan excretion (HP:0003541)3.86687218
19Abnormality of midbrain morphology (HP:0002418)3.83190019
20Molar tooth sign on MRI (HP:0002419)3.83190019
21Prolonged partial thromboplastin time (HP:0003645)3.82471014
22Insulin-resistant diabetes mellitus (HP:0000831)3.80280526
23Ketosis (HP:0001946)3.70462118
24Elevated erythrocyte sedimentation rate (HP:0003565)3.51292768
25Abnormality of mucopolysaccharide metabolism (HP:0011020)3.44605340
26Abnormality of polysaccharide metabolism (HP:0011012)3.44605340
27Abnormality of glycosaminoglycan metabolism (HP:0004371)3.44605340
28Abnormal pancreas size (HP:0012094)3.44117560
29Attenuation of retinal blood vessels (HP:0007843)3.40728547
30Pancreatic islet-cell hyperplasia (HP:0004510)3.40358636
31Pancreatic fibrosis (HP:0100732)3.36561288
32Decreased circulating renin level (HP:0003351)3.24140750
33Hyperventilation (HP:0002883)3.15114270
34Large for gestational age (HP:0001520)3.14979068
35Insulin resistance (HP:0000855)3.11641553
36Stomach cancer (HP:0012126)3.11296417
37Gout (HP:0001997)3.08611609
38Generalized aminoaciduria (HP:0002909)3.06960101
39True hermaphroditism (HP:0010459)3.05605619
40Nephronophthisis (HP:0000090)3.04548225
41Abnormality of the renal cortex (HP:0011035)2.99296566
42Progressive neurologic deterioration (HP:0002344)2.98950902
43Retrobulbar optic neuritis (HP:0100654)2.93861594
44Optic neuritis (HP:0100653)2.93861594
45Chronic hepatic failure (HP:0100626)2.91140197
46Abnormal delayed hypersensitivity skin test (HP:0002963)2.88398932
47Polydipsia (HP:0001959)2.86564359
48Abnormal drinking behavior (HP:0030082)2.86564359
49Panhypogammaglobulinemia (HP:0003139)2.78259817
50Conjugated hyperbilirubinemia (HP:0002908)2.76572301
51Recurrent cutaneous fungal infections (HP:0011370)2.76363467
52Chronic mucocutaneous candidiasis (HP:0002728)2.76363467
53Dynein arm defect of respiratory motile cilia (HP:0012255)2.73807727
54Absent/shortened dynein arms (HP:0200106)2.73807727
55Myositis (HP:0100614)2.73522567
56Abnormal rod and cone electroretinograms (HP:0008323)2.73242138
57Abnormality of calcium-phosphate metabolism (HP:0100530)2.70914857
58Vacuolated lymphocytes (HP:0001922)2.70298962
59Osteomalacia (HP:0002749)2.67874810
60Abnormality of the renal medulla (HP:0100957)2.65795707
61Recurrent fungal infections (HP:0002841)2.56698993
62Abolished electroretinogram (ERG) (HP:0000550)2.55641690
63Abnormal protein N-linked glycosylation (HP:0012347)2.55187879
64Abnormal protein glycosylation (HP:0012346)2.55187879
65Abnormal glycosylation (HP:0012345)2.55187879
66Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.55187879
67Type I transferrin isoform profile (HP:0003642)2.54517603
68Cystic liver disease (HP:0006706)2.52211789
69Orchitis (HP:0100796)2.50410506
70Abnormality of glycolipid metabolism (HP:0010969)2.46985517
71Abnormality of liposaccharide metabolism (HP:0010968)2.46985517
72Abnormality of glycosphingolipid metabolism (HP:0004343)2.46985517
73IgG deficiency (HP:0004315)2.46352705
74Hypokalemia (HP:0002900)2.45342882
75Intrahepatic cholestasis (HP:0001406)2.45212882
76Bile duct proliferation (HP:0001408)2.44985626
77Abnormal biliary tract physiology (HP:0012439)2.44985626
78Abdominal distention (HP:0003270)2.44117263
79Abnormality of the common coagulation pathway (HP:0010990)2.41401750
80Hypothermia (HP:0002045)2.40185765
81Abnormality of B cell number (HP:0010975)2.39288526
82Decreased electroretinogram (ERG) amplitude (HP:0000654)2.34284634
83Tubular atrophy (HP:0000092)2.33822853
84Hyperactive renin-angiotensin system (HP:0000841)2.31942569
85Pendular nystagmus (HP:0012043)2.30782431
86Absent speech (HP:0001344)2.30214023
87Turricephaly (HP:0000262)2.30029471
88Abnormality of renin-angiotensin system (HP:0000847)2.29904573
89Exocrine pancreatic insufficiency (HP:0001738)2.28642586
90Polyuria (HP:0000103)2.28170366
91Joint hemorrhage (HP:0005261)2.25537892
9211 pairs of ribs (HP:0000878)2.25254697
93Genetic anticipation (HP:0003743)2.24390191
94Abnormal respiratory epithelium morphology (HP:0012253)2.21810945
95Abnormal respiratory motile cilium morphology (HP:0005938)2.21810945
96Abnormality of purine metabolism (HP:0004352)2.19205278
97Hyperparathyroidism (HP:0000843)2.18374398
98Cortical visual impairment (HP:0100704)2.17277417
99Abnormality of T cell number (HP:0011839)2.16204403
100Abnormality of T cells (HP:0002843)2.16032758
101Encephalitis (HP:0002383)2.15720132
102Severe visual impairment (HP:0001141)2.15458806
103Progressive cerebellar ataxia (HP:0002073)2.15193616
104Dysautonomia (HP:0002459)2.14839303
105Retinal dysplasia (HP:0007973)2.14446974
106Hyperglycinuria (HP:0003108)2.12040663
107Abnormality of T cell physiology (HP:0011840)2.09697655
108Clumsiness (HP:0002312)2.09559436
109T lymphocytopenia (HP:0005403)2.09091503
110Inability to walk (HP:0002540)2.07896413
111Agitation (HP:0000713)2.07526392
112Renal cortical cysts (HP:0000803)2.05457343
113Thyroiditis (HP:0100646)2.05422676
114Protuberant abdomen (HP:0001538)2.05236606
115Severe combined immunodeficiency (HP:0004430)2.04763971
116Increased corneal curvature (HP:0100692)2.04596950
117Keratoconus (HP:0000563)2.04596950
118Sex reversal (HP:0012245)2.02867190
119Abnormal sex determination (HP:0012244)2.02867190
120Tachypnea (HP:0002789)2.02674458
121Hypochromic anemia (HP:0001931)2.02002874
122Missing ribs (HP:0000921)2.01531071
123Abnormality of monocarboxylic acid metabolism (HP:0010996)2.01231984
124Hypochromic microcytic anemia (HP:0004840)2.00450769
125Thoracolumbar scoliosis (HP:0002944)1.99989749
126Widely spaced teeth (HP:0000687)1.99292192
127Decreased central vision (HP:0007663)1.98519651
128Keratoconjunctivitis (HP:0001096)1.97213065
129Bony spicule pigmentary retinopathy (HP:0007737)1.96881867
130Pustule (HP:0200039)1.96742455
131Gaze-evoked nystagmus (HP:0000640)1.96070606
132Medial flaring of the eyebrow (HP:0010747)1.95379962
133Unilateral renal agenesis (HP:0000122)1.94227189
134Progressive muscle weakness (HP:0003323)1.93577209
135Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.93559968
136Hemoptysis (HP:0002105)1.92854921
137Concave nail (HP:0001598)1.90864445
138Lissencephaly (HP:0001339)1.90432448
139Broad face (HP:0000283)1.90345095
140Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.90009837
141Congenital hepatic fibrosis (HP:0002612)1.89913960
142Limb hypertonia (HP:0002509)1.89393446
143Beaking of vertebral bodies (HP:0004568)1.89348372
144Chronic bronchitis (HP:0004469)1.88726824
145Furrowed tongue (HP:0000221)1.84781358
146Progressive inability to walk (HP:0002505)1.84728086
147Macroorchidism (HP:0000053)1.84129404
148Glucose intolerance (HP:0000833)1.83057384
149Absent rod-and cone-mediated responses on ERG (HP:0007688)1.82816599
150Abnormality of the pons (HP:0007361)1.82357579
151Abnormal ciliary motility (HP:0012262)1.82313835
152Severe muscular hypotonia (HP:0006829)1.81204021
153Acute hepatic failure (HP:0006554)1.80811246
154Bifid tongue (HP:0010297)1.80283668
155Meningitis (HP:0001287)1.80168880
156Progressive microcephaly (HP:0000253)1.79813810
157Xanthomatosis (HP:0000991)1.79783498
158Protruding tongue (HP:0010808)1.79122450
159Type II lissencephaly (HP:0007260)1.78102283
160Reduced antithrombin III activity (HP:0001976)1.77814497
161B lymphocytopenia (HP:0010976)1.77539136
162Hypotension (HP:0002615)1.77190926
163Abnormal urine output (HP:0012590)1.76032473
164Hypophosphatemia (HP:0002148)1.75653691
165Broad-based gait (HP:0002136)1.74201142
166Abnormality of alkaline phosphatase activity (HP:0004379)1.73763580
167Growth hormone excess (HP:0000845)1.72893485
168Abnormality of the prostate (HP:0008775)1.72741527
169Abnormality of potassium homeostasis (HP:0011042)1.72430336
170Cardiomegaly (HP:0001640)1.72368423
171Gastrointestinal infarctions (HP:0005244)1.71578313
172Hypoproteinemia (HP:0003075)1.71162884
173Abnormality of transition element cation homeostasis (HP:0011030)1.70955940
174Abnormal enzyme/coenzyme activity (HP:0012379)1.70645228
175Delayed CNS myelination (HP:0002188)1.69853924
176Cerebellar dysplasia (HP:0007033)1.69464321
177Alveolar cell carcinoma (HP:0006519)1.69459381
178Sclerocornea (HP:0000647)1.69349876
179Aplasia/Hypoplasia of the spleen (HP:0010451)1.68555146
180Hyperphosphaturia (HP:0003109)1.68224005
181Hypoplasia of the fovea (HP:0007750)1.68153130
182Aplasia/Hypoplasia of the fovea (HP:0008060)1.68153130
183Generalized hyperpigmentation (HP:0007440)1.67631868
184Vasculitis (HP:0002633)1.66943586
185Elevated alkaline phosphatase (HP:0003155)1.66856720
186Congenital glaucoma (HP:0001087)1.66848914
187Irritability (HP:0000737)1.66834745
188Hypoalbuminemia (HP:0003073)1.66820048
189Abnormal albumin level (HP:0012116)1.66820048
190Pulmonary infiltrates (HP:0002113)1.66469336
191Prominent metopic ridge (HP:0005487)1.65270508
192Abnormality of the anterior horn cell (HP:0006802)1.65123117
193Degeneration of anterior horn cells (HP:0002398)1.65123117
194Anteriorly placed anus (HP:0001545)1.64868052
195Skin nodule (HP:0200036)1.64784085

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR5.77945398
2PASK4.55588756
3MAPK154.14423450
4TXK4.06946783
5ERN13.63327530
6FLT33.47958467
7BCKDK3.28970447
8ADRBK23.14194943
9TLK12.91752401
10HIPK22.89514052
11MAP4K22.58556011
12MAP4K12.54041672
13ERBB32.36665450
14TAOK32.25216364
15STK162.20742881
16PINK12.08265588
17EIF2AK32.07051031
18GRK62.02690809
19TNK21.99817224
20PTK61.94277534
21MAP3K21.89244948
22NUAK11.89165165
23PIK3CG1.82450503
24SIK11.82102505
25GRK11.81359609
26TRIB31.81241243
27MAP2K21.76039208
28IKBKE1.75187825
29IRAK11.67052240
30ZAK1.54603422
31MET1.51524480
32SYK1.47958380
33FRK1.47308508
34MAPK131.41303392
35WNK41.40452170
36IKBKB1.38346294
37PTK21.38208036
38EPHA31.37356089
39MAPKAPK51.35727555
40PDGFRA1.34513360
41PAK31.34389522
42SIK21.34062416
43BLK1.33792520
44FES1.33123005
45IRAK21.31918232
46NME11.29969433
47BMPR1B1.27771125
48CSF1R1.25684808
49NLK1.23052905
50PTK2B1.17757031
51OXSR11.12217182
52DYRK1B1.12199819
53LCK1.11099324
54ACVR1B1.10775091
55TYK21.09826094
56TNIK1.05982316
57PRKD31.05694625
58FGFR41.05426594
59FER1.04208555
60KIT1.01085285
61DAPK20.98547680
62LYN0.98078882
63PKN20.97751120
64PIK3CA0.96808627
65CDC42BPA0.95219015
66SIK30.94297956
67RIPK40.94282994
68ADRBK10.94236654
69MAP2K60.92221414
70ITK0.92159928
71BTK0.91538300
72HCK0.90988020
73NTRK10.90621714
74MAP3K10.90210847
75TAOK10.90086497
76PRKCQ0.87423878
77SCYL20.86785134
78ZAP700.85122142
79BRD40.84070391
80MAP3K70.83927541
81UHMK10.81937329
82MARK30.81871579
83TEC0.81017923
84TBK10.78019844
85EPHA20.73896714
86IRAK30.72850993
87STK110.71683066
88MAP3K40.71212820
89RPS6KA50.70478420
90KSR20.68479363
91BMPR20.66415534
92MAP2K10.65473050
93DYRK20.64833376
94DMPK0.64349039
95PRKCI0.64229663
96AKT30.63621620
97RPS6KB20.62903998
98RPS6KA60.61514581
99RPS6KA20.61293964
100TRPM70.60236222
101PRKCH0.59956964
102PHKG10.59027767
103PHKG20.59027767
104CAMKK10.58070819
105GSK3A0.56850274
106CAMKK20.54926779
107PRKD20.54739487
108GRK70.54231437
109MAPK110.52449919
110CSNK1G10.52197383
111CASK0.51603297
112CSK0.51504531
113JAK10.50601202
114WNK30.49197181
115MKNK10.48535587
116MAPKAPK20.47655831
117MUSK0.47589842
118JAK30.47566931
119BRAF0.47290384
120MAPKAPK30.46281598
121ABL10.46259209
122MAP3K140.45864761
123NTRK30.44826593
124PRKCE0.43406258
125JAK20.43149356
126MTOR0.42569840
127PDK10.41969610
128CHUK0.41650495
129MAP2K30.41169142
130BRSK20.40782467
131VRK10.40778449
132MARK20.40091423
133CSNK1A1L0.39053034
134MAP3K30.37124916
135PRKCG0.35067357
136MAPK30.35016721
137CAMK40.34085936
138PDGFRB0.34072889
139CAMK2D0.32754248
140EPHB10.31984404
141PRKCZ0.31799217
142WNK10.31515055
143IGF1R0.31440668
144PRKACG0.31104833
145MAPK70.31067307
146CAMK10.30952725
147DYRK30.30658076
148PIM10.30424475
149RAF10.30354253
150NME20.30036275
151PRKG20.29346834
152TGFBR10.29272970
153BCR0.29214148
154FGFR20.28412431
155RPS6KL10.28408550
156RPS6KC10.28408550
157PRKAA20.27463440
158TGFBR20.27008830
159RPS6KB10.25314408
160PRKAA10.24946028
161KDR0.24838229
162CDK90.24339385
163CSNK1A10.22154771
164PRKD10.20827786
165IRAK40.20778679

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049508.53324884
2Protein export_Homo sapiens_hsa030605.99330536
3Sulfur metabolism_Homo sapiens_hsa009203.73354019
4Protein processing in endoplasmic reticulum_Homo sapiens_hsa041413.57529997
5Primary immunodeficiency_Homo sapiens_hsa053403.03228213
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.88911334
7Folate biosynthesis_Homo sapiens_hsa007902.53476565
8Selenocompound metabolism_Homo sapiens_hsa004502.44473380
9Graft-versus-host disease_Homo sapiens_hsa053322.37013919
10Allograft rejection_Homo sapiens_hsa053302.36730924
11Autoimmune thyroid disease_Homo sapiens_hsa053202.31404603
12Phototransduction_Homo sapiens_hsa047442.28787924
13N-Glycan biosynthesis_Homo sapiens_hsa005102.21263212
14Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.07533603
15Insulin secretion_Homo sapiens_hsa049112.07264438
16Asthma_Homo sapiens_hsa053102.00102364
17Carbohydrate digestion and absorption_Homo sapiens_hsa049731.97504804
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.90538071
19Nitrogen metabolism_Homo sapiens_hsa009101.90036542
20Other glycan degradation_Homo sapiens_hsa005111.84242865
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.82802568
22Tryptophan metabolism_Homo sapiens_hsa003801.80483115
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.73682276
24Fatty acid degradation_Homo sapiens_hsa000711.72429486
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.68952490
26Vibrio cholerae infection_Homo sapiens_hsa051101.68067000
27Histidine metabolism_Homo sapiens_hsa003401.60196606
28Glycosaminoglycan degradation_Homo sapiens_hsa005311.58061578
29Ether lipid metabolism_Homo sapiens_hsa005651.52629830
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.48026764
31Lysosome_Homo sapiens_hsa041421.44269538
32Olfactory transduction_Homo sapiens_hsa047401.36776493
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.36494021
34NOD-like receptor signaling pathway_Homo sapiens_hsa046211.35565268
35T cell receptor signaling pathway_Homo sapiens_hsa046601.35350081
36Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.31342150
37Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.28660423
38Butanoate metabolism_Homo sapiens_hsa006501.28241615
39Staphylococcus aureus infection_Homo sapiens_hsa051501.28123441
40Type II diabetes mellitus_Homo sapiens_hsa049301.25584599
41Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.22445222
42Rheumatoid arthritis_Homo sapiens_hsa053231.18346582
43RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.15928301
44Hematopoietic cell lineage_Homo sapiens_hsa046401.14380666
45Galactose metabolism_Homo sapiens_hsa000521.11340125
46Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.09203998
47NF-kappa B signaling pathway_Homo sapiens_hsa040641.07502409
48Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.07210847
49Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.05732808
50Pentose and glucuronate interconversions_Homo sapiens_hsa000401.05040445
51Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.02517893
52Circadian rhythm_Homo sapiens_hsa047101.02431348
53Leishmaniasis_Homo sapiens_hsa051401.01797517
54Morphine addiction_Homo sapiens_hsa050321.01473920
55Insulin resistance_Homo sapiens_hsa049311.01299712
56SNARE interactions in vesicular transport_Homo sapiens_hsa041300.97451347
57Primary bile acid biosynthesis_Homo sapiens_hsa001200.97301889
58Regulation of autophagy_Homo sapiens_hsa041400.96126052
59Fatty acid metabolism_Homo sapiens_hsa012120.95461467
60Glucagon signaling pathway_Homo sapiens_hsa049220.94570972
61Fructose and mannose metabolism_Homo sapiens_hsa000510.94411171
62Jak-STAT signaling pathway_Homo sapiens_hsa046300.91494413
63RNA polymerase_Homo sapiens_hsa030200.91032033
64Linoleic acid metabolism_Homo sapiens_hsa005910.89362783
65Osteoclast differentiation_Homo sapiens_hsa043800.88322933
66Taste transduction_Homo sapiens_hsa047420.86834445
67alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.86152181
68Pancreatic secretion_Homo sapiens_hsa049720.83235051
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.80394696
70Tuberculosis_Homo sapiens_hsa051520.80082042
71Oxidative phosphorylation_Homo sapiens_hsa001900.79447951
72Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.79139677
73Homologous recombination_Homo sapiens_hsa034400.78657791
74ABC transporters_Homo sapiens_hsa020100.77957742
75Fat digestion and absorption_Homo sapiens_hsa049750.77490996
76Starch and sucrose metabolism_Homo sapiens_hsa005000.76623302
77Nicotine addiction_Homo sapiens_hsa050330.76484219
78Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.74413745
79Type I diabetes mellitus_Homo sapiens_hsa049400.73863947
80Dorso-ventral axis formation_Homo sapiens_hsa043200.73692174
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.72970318
82Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.72521757
83B cell receptor signaling pathway_Homo sapiens_hsa046620.72308013
84Arginine and proline metabolism_Homo sapiens_hsa003300.72223695
85Fanconi anemia pathway_Homo sapiens_hsa034600.71603255
86Peroxisome_Homo sapiens_hsa041460.71135953
87Salivary secretion_Homo sapiens_hsa049700.70201793
88Cocaine addiction_Homo sapiens_hsa050300.69898354
89Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.69687530
90Thyroid hormone synthesis_Homo sapiens_hsa049180.69061919
91Propanoate metabolism_Homo sapiens_hsa006400.68140770
92Prolactin signaling pathway_Homo sapiens_hsa049170.66923770
93Glycerolipid metabolism_Homo sapiens_hsa005610.66243429
94beta-Alanine metabolism_Homo sapiens_hsa004100.65879222
95Serotonergic synapse_Homo sapiens_hsa047260.64372985
96Arachidonic acid metabolism_Homo sapiens_hsa005900.63176000
97Measles_Homo sapiens_hsa051620.62997951
98Lysine degradation_Homo sapiens_hsa003100.62920233
99Drug metabolism - other enzymes_Homo sapiens_hsa009830.61645978
100RNA degradation_Homo sapiens_hsa030180.61532942
101Thyroid cancer_Homo sapiens_hsa052160.60955653
102Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.60430495
103Platelet activation_Homo sapiens_hsa046110.60400192
104Chemokine signaling pathway_Homo sapiens_hsa040620.59679805
105Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.59325133
106Calcium signaling pathway_Homo sapiens_hsa040200.59012547
107Basal transcription factors_Homo sapiens_hsa030220.57053937
108Retinol metabolism_Homo sapiens_hsa008300.55294800
109Pyruvate metabolism_Homo sapiens_hsa006200.54568678
110Insulin signaling pathway_Homo sapiens_hsa049100.53962137
111Herpes simplex infection_Homo sapiens_hsa051680.52063256
112Vascular smooth muscle contraction_Homo sapiens_hsa042700.51854601
113Viral myocarditis_Homo sapiens_hsa054160.51168079
114Tyrosine metabolism_Homo sapiens_hsa003500.51056517
115Phenylalanine metabolism_Homo sapiens_hsa003600.50981254
116PPAR signaling pathway_Homo sapiens_hsa033200.49691942
117African trypanosomiasis_Homo sapiens_hsa051430.49018933
118Prion diseases_Homo sapiens_hsa050200.47681745
119Circadian entrainment_Homo sapiens_hsa047130.47196052
120Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.46930925
121AMPK signaling pathway_Homo sapiens_hsa041520.45296136
122Sulfur relay system_Homo sapiens_hsa041220.45278190
123Glutamatergic synapse_Homo sapiens_hsa047240.45179829
124Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.44914603
125Fatty acid elongation_Homo sapiens_hsa000620.44601283
126Sphingolipid metabolism_Homo sapiens_hsa006000.44031353
127TNF signaling pathway_Homo sapiens_hsa046680.41582751
128Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.40832816
129Choline metabolism in cancer_Homo sapiens_hsa052310.37993480
130Protein digestion and absorption_Homo sapiens_hsa049740.37974141
131Prostate cancer_Homo sapiens_hsa052150.37278067
132Oxytocin signaling pathway_Homo sapiens_hsa049210.37141869
133Adipocytokine signaling pathway_Homo sapiens_hsa049200.37087732
134Acute myeloid leukemia_Homo sapiens_hsa052210.36108082
135Longevity regulating pathway - mammal_Homo sapiens_hsa042110.35832464
136Cholinergic synapse_Homo sapiens_hsa047250.35540451
137Toll-like receptor signaling pathway_Homo sapiens_hsa046200.34735897
138Chemical carcinogenesis_Homo sapiens_hsa052040.33753392
139Aldosterone synthesis and secretion_Homo sapiens_hsa049250.32933400
140Metabolic pathways_Homo sapiens_hsa011000.32678501
141Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.32586636
142Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.31961604
143Complement and coagulation cascades_Homo sapiens_hsa046100.27414303
144Glycerophospholipid metabolism_Homo sapiens_hsa005640.26028027
145Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.25994064
146Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.24993730
147Bladder cancer_Homo sapiens_hsa052190.23856735
148Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.22584678
149Endometrial cancer_Homo sapiens_hsa052130.21334647
150Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.20638459
151Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.19786578
152Steroid hormone biosynthesis_Homo sapiens_hsa001400.17436504
153Amphetamine addiction_Homo sapiens_hsa050310.15502874
154Estrogen signaling pathway_Homo sapiens_hsa049150.15106379
155Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.15004759
156Chronic myeloid leukemia_Homo sapiens_hsa052200.14286767
157Ovarian steroidogenesis_Homo sapiens_hsa049130.13774368
158Phosphatidylinositol signaling system_Homo sapiens_hsa040700.12632653
159Inositol phosphate metabolism_Homo sapiens_hsa005620.09741648
160Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.09727383
161Collecting duct acid secretion_Homo sapiens_hsa049660.07502425
162Antigen processing and presentation_Homo sapiens_hsa046120.06676143
163Caffeine metabolism_Homo sapiens_hsa002320.06655407

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