VMP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a transmembrane protein that plays a key regulatory role in the process of autophagy. The ectopic overexpression of the encoded protein in cultured cells triggers autophagy even under nutrient-rich conditions. This gene is overexpressed in pancreatitis affected acinar cells where the encoded protein mediates sequestration and degradation of potentially deleterious activated zymogen granules in a process termed, zymophagy. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)9.41749662
2axon ensheathment in central nervous system (GO:0032291)9.41749662
3fatty acid elongation (GO:0030497)7.18519458
4positive regulation of chemokine secretion (GO:0090197)5.77887823
5long-chain fatty acid biosynthetic process (GO:0042759)5.43566708
6regulation of chemokine secretion (GO:0090196)5.34987246
7ensheathment of neurons (GO:0007272)5.08746162
8axon ensheathment (GO:0008366)5.08746162
9myelination (GO:0042552)5.07386539
10negative regulation of complement activation (GO:0045916)4.91373532
11negative regulation of protein activation cascade (GO:2000258)4.52802738
12hepatocyte apoptotic process (GO:0097284)4.49819255
13negative regulation of neurotransmitter secretion (GO:0046929)4.49119948
14cholesterol biosynthetic process (GO:0006695)4.46113462
15positive regulation of macrophage activation (GO:0043032)4.38976060
16iron ion import (GO:0097286)4.27429217
17negative regulation of neurotransmitter transport (GO:0051589)4.23086537
18endocrine hormone secretion (GO:0060986)4.20885879
19amyloid precursor protein metabolic process (GO:0042982)4.09186849
20sterol biosynthetic process (GO:0016126)4.00962278
21negative regulation of humoral immune response (GO:0002921)3.94472412
22myelin maintenance (GO:0043217)3.91417099
23isoprenoid biosynthetic process (GO:0008299)3.86615069
24detection of molecule of bacterial origin (GO:0032490)3.84130542
25adhesion of symbiont to host cell (GO:0044650)3.81722526
26virion attachment to host cell (GO:0019062)3.81722526
27protein neddylation (GO:0045116)3.81248590
28neutrophil activation involved in immune response (GO:0002283)3.77488721
29amyloid precursor protein catabolic process (GO:0042987)3.70995808
30regulation of interleukin-5 production (GO:0032674)3.70377366
31mesodermal cell differentiation (GO:0048333)3.66218568
32nucleotide transmembrane transport (GO:1901679)3.65125737
33regulation of collateral sprouting (GO:0048670)3.61613537
34negative regulation of protein localization to cell surface (GO:2000009)3.55579430
35glycerophospholipid catabolic process (GO:0046475)3.52301526
36oligodendrocyte differentiation (GO:0048709)3.50183782
37long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.48917977
38presynaptic membrane organization (GO:0097090)3.41143122
39GPI anchor biosynthetic process (GO:0006506)3.39410949
40signal peptide processing (GO:0006465)3.33060486
41glycosylceramide metabolic process (GO:0006677)3.32943775
42regulation of lipoprotein metabolic process (GO:0050746)3.31420824
43creatine metabolic process (GO:0006600)3.29031826
44cellular response to ethanol (GO:0071361)3.27658484
45response to redox state (GO:0051775)3.27486607
46negative regulation of acute inflammatory response (GO:0002674)3.26383373
47long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.22618171
48presynaptic membrane assembly (GO:0097105)3.22242752
49import into cell (GO:0098657)3.21825321
50photoreceptor cell differentiation (GO:0046530)3.18086599
51eye photoreceptor cell differentiation (GO:0001754)3.18086599
52response to lipoprotein particle (GO:0055094)3.17184484
53intracellular pH reduction (GO:0051452)3.13098419
54regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.12608250
55interleukin-6-mediated signaling pathway (GO:0070102)3.10873610
56GPI anchor metabolic process (GO:0006505)3.09722329
57positive regulation of interleukin-17 production (GO:0032740)3.08489081
58preassembly of GPI anchor in ER membrane (GO:0016254)3.06005918
59positive regulation of oligodendrocyte differentiation (GO:0048714)3.03925530
60membrane raft organization (GO:0031579)3.03524250
61macrophage activation involved in immune response (GO:0002281)3.00695984
62pH reduction (GO:0045851)2.98920222
63fatty-acyl-CoA biosynthetic process (GO:0046949)2.98254651
64intestinal epithelial cell development (GO:0060576)2.97030474
65regulation of gonadotropin secretion (GO:0032276)2.94085201
66fatty-acyl-CoA metabolic process (GO:0035337)2.93485871
67positive regulation by symbiont of host defense response (GO:0052509)2.92915933
68modulation by symbiont of host defense response (GO:0052031)2.92915933
69modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.92915933
70modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.92915933
71positive regulation by organism of defense response of other organism involved in symbiotic interact2.92915933
72modulation by symbiont of host immune response (GO:0052553)2.92915933
73mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.91626561
74positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.91626561
75negative regulation of interferon-gamma production (GO:0032689)2.88799282
76regulation of endothelial cell chemotaxis (GO:2001026)2.88077153
77production of molecular mediator involved in inflammatory response (GO:0002532)2.85754250
78adhesion of symbiont to host (GO:0044406)2.84264600
79mannosylation (GO:0097502)2.83565309
80positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.83136921
81positive regulation of cellular amine metabolic process (GO:0033240)2.81889243
82lung vasculature development (GO:0060426)2.80844265
83negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.79818312
84cell adhesion mediated by integrin (GO:0033627)2.79212787
85very long-chain fatty acid metabolic process (GO:0000038)2.77986272
86astrocyte development (GO:0014002)2.77839003
87macrophage activation (GO:0042116)2.77343872
88cellular extravasation (GO:0045123)2.77009815
89L-amino acid import (GO:0043092)2.76305002
90platelet-derived growth factor receptor signaling pathway (GO:0048008)2.76231968
91negative regulation of chemokine production (GO:0032682)2.75213433
92regulation of interferon-beta biosynthetic process (GO:0045357)2.74195268
93positive regulation of interferon-alpha production (GO:0032727)2.73524801
94leukocyte migration involved in inflammatory response (GO:0002523)2.72026931
95magnesium ion transport (GO:0015693)2.70575702
96positive regulation of toll-like receptor signaling pathway (GO:0034123)2.70552388
97apical protein localization (GO:0045176)2.69703567
98substantia nigra development (GO:0021762)2.68886116
99positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.68710568
100response to methylmercury (GO:0051597)2.67103900
101response to peptidoglycan (GO:0032494)2.66301649
102negative regulation of JUN kinase activity (GO:0043508)2.65529570
103asymmetric protein localization (GO:0008105)2.63553095
104regulation of T-helper 1 type immune response (GO:0002825)2.62812000
105establishment of protein localization to Golgi (GO:0072600)2.62806503
106UDP-N-acetylglucosamine metabolic process (GO:0006047)2.62365541
107positive regulation of macrophage differentiation (GO:0045651)2.61883192
108positive regulation of tyrosine phosphorylation of Stat3 protein (GO:0042517)2.60509072
109erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.60254251
110L-phenylalanine catabolic process (GO:0006559)2.60254251
111regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.59134893
112positive regulation of pseudopodium assembly (GO:0031274)2.59134103
113glutathione derivative biosynthetic process (GO:1901687)2.58690837
114glutathione derivative metabolic process (GO:1901685)2.58690837
115regulation of macrophage differentiation (GO:0045649)2.58615423
116fibroblast migration (GO:0010761)2.56825812
117positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.56202647
118nucleotide transport (GO:0006862)2.54452926
119negative regulation of macrophage differentiation (GO:0045650)2.54122240
120regulation of interferon-alpha production (GO:0032647)2.54047537
121regulation of macrophage activation (GO:0043030)2.53820909
122glutathione biosynthetic process (GO:0006750)2.53274924
123heme transport (GO:0015886)2.53227741
124definitive hemopoiesis (GO:0060216)2.53108623
125regulation of apoptotic process involved in morphogenesis (GO:1902337)2.52608879
126autophagic vacuole fusion (GO:0000046)2.51557931
127cellular response to interferon-alpha (GO:0035457)2.50913602
128regulation of cell proliferation involved in kidney development (GO:1901722)2.50262397
129negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.50200347
130eyelid development in camera-type eye (GO:0061029)2.50078431
131positive regulation of chemokine production (GO:0032722)2.49641907
132L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.47689528
133T-helper 1 type immune response (GO:0042088)2.47257714
134estrogen biosynthetic process (GO:0006703)2.46912205
135microglial cell activation (GO:0001774)2.45759809
136negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.45736459
137endothelial cell chemotaxis (GO:0035767)2.45419811
138Rap protein signal transduction (GO:0032486)2.45418041
139detection of external biotic stimulus (GO:0098581)2.44202029
140interferon-gamma secretion (GO:0072643)2.44146753
141regulation of establishment of cell polarity (GO:2000114)2.42223591
142COPII vesicle coating (GO:0048208)2.41387659
143nonribosomal peptide biosynthetic process (GO:0019184)2.41295993
144pyrimidine-containing compound transmembrane transport (GO:0072531)2.41032458
145response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.41007719
146response to host (GO:0075136)2.41007719
147response to host defenses (GO:0052200)2.41007719
148regulation of T cell migration (GO:2000404)2.40693368
149retrograde transport, vesicle recycling within Golgi (GO:0000301)2.40540509
150response to interferon-alpha (GO:0035455)2.40135215
151positive regulation of actin filament depolymerization (GO:0030836)2.40001040
152regulation of T-helper 2 cell differentiation (GO:0045628)2.39844979
153negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.39303640
154regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.39201477
155establishment of mitochondrion localization (GO:0051654)2.38949046
156estrogen metabolic process (GO:0008210)2.38939400
157negative regulation of adaptive immune response (GO:0002820)2.38831276
158ear development (GO:0043583)2.38692418
159striated muscle atrophy (GO:0014891)2.38315399
160response to lead ion (GO:0010288)2.38298299
161protein targeting to Golgi (GO:0000042)2.37260287
162regulation of interleukin-12 biosynthetic process (GO:0045075)2.37170697
163thioester biosynthetic process (GO:0035384)2.36849945
164acyl-CoA biosynthetic process (GO:0071616)2.36849945
165protein palmitoylation (GO:0018345)2.35979958
166membrane tubulation (GO:0097320)2.35971894
167pericardium development (GO:0060039)2.35825712
168aldehyde catabolic process (GO:0046185)2.35325633
169negative regulation of T-helper cell differentiation (GO:0045623)2.35184788
170negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.35184788
171positive regulation of catenin import into nucleus (GO:0035413)2.34783625
172ER overload response (GO:0006983)2.34683828
173C-terminal protein lipidation (GO:0006501)2.34525280
174positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.34264905
175negative regulation of protein autophosphorylation (GO:0031953)2.34129322
176antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.34061769
177cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.33976099
178regulation of interleukin-8 biosynthetic process (GO:0045414)2.32550021
179positive regulation of Cdc42 GTPase activity (GO:0043089)2.30627878
180embryonic process involved in female pregnancy (GO:0060136)2.29753169
181wound healing, spreading of epidermal cells (GO:0035313)2.29711282
182macroautophagy (GO:0016236)2.29579092
183chondrocyte development (GO:0002063)2.29100137
184regulation of establishment or maintenance of cell polarity (GO:0032878)2.28974938
185regulation of complement activation (GO:0030449)2.26586356
186positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.24247267
187positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.24247267
188positive regulation of mitotic sister chromatid separation (GO:1901970)2.24247267
189protein targeting to vacuole (GO:0006623)2.20312802
190protein targeting to lysosome (GO:0006622)2.20312802
191establishment of protein localization to vacuole (GO:0072666)2.20312802
192diterpenoid biosynthetic process (GO:0016102)2.19613887
193negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.19564023
194antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.19294364

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.38299044
2ESR1_21235772_ChIP-Seq_MCF-7_Human3.36457229
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.18336807
4GBX2_23144817_ChIP-Seq_PC3_Human3.14236561
5STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.07451913
6ZNF217_24962896_ChIP-Seq_MCF-7_Human2.89286763
7ESR1_20079471_ChIP-ChIP_T-47D_Human2.88250612
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.87512814
9SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.73900120
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.71029614
11SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.47677956
12ESR2_21235772_ChIP-Seq_MCF-7_Human2.47287132
13TAF15_26573619_Chip-Seq_HEK293_Human2.45159033
14IRF8_21731497_ChIP-ChIP_J774_Mouse2.31622387
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.28538478
16CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.23656430
17STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.22555419
18HIF1A_21447827_ChIP-Seq_MCF-7_Human2.22365317
19AHR_22903824_ChIP-Seq_MCF-7_Human2.20686127
20POU3F2_20337985_ChIP-ChIP_501MEL_Human2.17748018
21SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.15293838
22SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.15293838
23NRF2_20460467_ChIP-Seq_MEFs_Mouse2.14529457
24NFE2L2_20460467_ChIP-Seq_MEFs_Mouse2.14529457
25ER_23166858_ChIP-Seq_MCF-7_Human2.06901791
26EGR1_19374776_ChIP-ChIP_THP-1_Human2.03156937
27NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.02985679
28PPAR_26484153_Chip-Seq_NCI-H1993_Human2.01367956
29MYB_21317192_ChIP-Seq_ERMYB_Mouse1.96847487
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.96249090
31NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.91717468
32STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.91665532
33OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.90789912
34Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.88856101
35BP1_19119308_ChIP-ChIP_Hs578T_Human1.88578474
36FOXM1_26456572_ChIP-Seq_MCF-7_Human1.87523293
37TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.87321404
38TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.80657647
39GATA1_22025678_ChIP-Seq_K562_Human1.80463144
40FOXO3_23340844_ChIP-Seq_DLD1_Human1.77896770
41ARNT_22903824_ChIP-Seq_MCF-7_Human1.71553151
42CDX2_19796622_ChIP-Seq_MESCs_Mouse1.69985724
43NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.68245720
44STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.68154930
45SMAD_19615063_ChIP-ChIP_OVARY_Human1.67843779
46PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.67740958
47VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.65139614
48CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.64355320
49BRD4_25478319_ChIP-Seq_HGPS_Human1.64261930
50CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.61577244
51TP63_17297297_ChIP-ChIP_HaCaT_Human1.60790144
52TRIM28_21343339_ChIP-Seq_HEK293_Human1.60410516
53ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.58498570
54FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.56402831
55SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.54749849
56EGR1_23403033_ChIP-Seq_LIVER_Mouse1.53127034
57WT1_19549856_ChIP-ChIP_CCG9911_Human1.52839792
58VDR_22108803_ChIP-Seq_LS180_Human1.50512934
59FUS_26573619_Chip-Seq_HEK293_Human1.50501971
60GATA2_21666600_ChIP-Seq_HMVEC_Human1.47320112
61JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.45282264
62VDR_24787735_ChIP-Seq_THP-1_Human1.45138050
63PCGF2_27294783_Chip-Seq_ESCs_Mouse1.43724376
64JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.42757212
65IRF8_22096565_ChIP-ChIP_GC-B_Human1.40408995
66ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.39576291
67FLI1_27457419_Chip-Seq_LIVER_Mouse1.39498291
68P300_19829295_ChIP-Seq_ESCs_Human1.39071621
69PIAS1_25552417_ChIP-Seq_VCAP_Human1.36941982
70EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.35288476
71FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.35250709
72SOX2_20726797_ChIP-Seq_SW620_Human1.32954776
73IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.31959049
74SUZ12_18555785_Chip-Seq_ESCs_Mouse1.31008240
75LXR_22158963_ChIP-Seq_LIVER_Mouse1.30837354
76IRF1_19129219_ChIP-ChIP_H3396_Human1.30807062
77HTT_18923047_ChIP-ChIP_STHdh_Human1.27983204
78IRF8_27001747_Chip-Seq_BMDM_Mouse1.26071488
79CMYC_18555785_Chip-Seq_ESCs_Mouse1.24723093
80SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.23364917
81LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22155389
82P300_18555785_Chip-Seq_ESCs_Mouse1.21131505
83RUNX1_27514584_Chip-Seq_MCF-7_Human1.20781554
84SMAD3_21741376_ChIP-Seq_EPCs_Human1.20198574
85GATA3_24758297_ChIP-Seq_MCF-7_Human1.20123212
86AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.19858952
87NANOG_18555785_Chip-Seq_ESCs_Mouse1.19282825
88GATA6_25053715_ChIP-Seq_YYC3_Human1.18731204
89TAL1_26923725_Chip-Seq_HPCs_Mouse1.18617375
90NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.18418012
91SUZ12_27294783_Chip-Seq_NPCs_Mouse1.18217500
92TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.18017506
93ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.17519338
94SCL_19346495_ChIP-Seq_HPC-7_Human1.17390321
95RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17052877
96CTNNB1_20460455_ChIP-Seq_HCT116_Human1.16502126
97EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.15768946
98EZH2_27294783_Chip-Seq_NPCs_Mouse1.15083502
99SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.15036792
100STAT3_18555785_Chip-Seq_ESCs_Mouse1.14917613
101RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.13840072
102SOX2_27498859_Chip-Seq_STOMACH_Mouse1.13455500
103PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.12986191
104GATA4_25053715_ChIP-Seq_YYC3_Human1.11226485
105EWS_26573619_Chip-Seq_HEK293_Human1.10947895
106TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.10181312
107P53_22387025_ChIP-Seq_ESCs_Mouse1.09733118
108SMAD1_18555785_Chip-Seq_ESCs_Mouse1.09414682
109CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.09232527
110TP63_23658742_ChIP-Seq_EP156T_Human1.09106604
111LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.08025723
112EOMES_21245162_ChIP-Seq_HESCs_Human1.08015275
113E2F1_18555785_Chip-Seq_ESCs_Mouse1.07558244
114CDX2_20551321_ChIP-Seq_CACO-2_Human1.07401177
115RUNX1_27457419_Chip-Seq_LIVER_Mouse1.07112605
116SOX2_18555785_Chip-Seq_ESCs_Mouse1.06175143
117UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05963814
118AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.05842481
119PCGF2_27294783_Chip-Seq_NPCs_Mouse1.05790578
120KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.05595379
121TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.05485199
122SOX9_24532713_ChIP-Seq_HFSC_Mouse1.05142597
123EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.04774654
124TP53_18474530_ChIP-ChIP_U2OS_Human1.04655017
125IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.04465119
126NANOG_19829295_ChIP-Seq_ESCs_Human1.02760630
127SOX2_19829295_ChIP-Seq_ESCs_Human1.02760630
128RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.02211014
129PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00481005
130FOXA2_19822575_ChIP-Seq_HepG2_Human0.99786708
131CTBP1_25329375_ChIP-Seq_LNCAP_Human0.99393274
132CRX_20693478_ChIP-Seq_RETINA_Mouse0.99358550
133MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.98628719
134NFE2_27457419_Chip-Seq_LIVER_Mouse0.98292315
135ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97257023
136KLF4_18555785_Chip-Seq_ESCs_Mouse0.96834219
137CTBP2_25329375_ChIP-Seq_LNCAP_Human0.96679699
138NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.96497349
139TCF4_18268006_ChIP-ChIP_LS174T_Human0.95842089
140SALL1_21062744_ChIP-ChIP_HESCs_Human0.95781343
141FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.95510791
142ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.94981074
143CJUN_26792858_Chip-Seq_BT549_Human0.94504195
144STAT4_19710469_ChIP-ChIP_TH1__Mouse0.94272799
145RUNX_20019798_ChIP-Seq_JUKART_Human0.93888554
146PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.93844870
147PRDM14_20953172_ChIP-Seq_ESCs_Human0.93453886
148SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.92809032
149OCT4_18555785_Chip-Seq_ESCs_Mouse0.92610802
150P53_22127205_ChIP-Seq_FIBROBLAST_Human0.92484124
151SALL4_18804426_ChIP-ChIP_XEN_Mouse0.92142148
152PU1_27457419_Chip-Seq_LIVER_Mouse0.91922481
153MYB_26560356_Chip-Seq_TH1_Human0.91523939
154AR_21572438_ChIP-Seq_LNCaP_Human0.91434877
155FOXA1_21572438_ChIP-Seq_LNCaP_Human0.90806709
156TP53_16413492_ChIP-PET_HCT116_Human0.90751146
157STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.90503308
158CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.90498220
159TOP2B_26459242_ChIP-Seq_MCF-7_Human0.89548891
160RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.87699172
161BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.87688597
162CDX2_22108803_ChIP-Seq_LS180_Human0.86954312
163STAT6_21828071_ChIP-Seq_BEAS2B_Human0.86196039
164CLOCK_20551151_ChIP-Seq_293T_Human0.84879426
165PU_27001747_Chip-Seq_BMDM_Mouse0.82035350
166KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.81365928
167PKCTHETA_26484144_Chip-Seq_BREAST_Human0.81271323

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination5.11305454
2MP0003950_abnormal_plasma_membrane3.65996278
3MP0003690_abnormal_glial_cell3.03133688
4MP0002009_preneoplasia2.86484331
5MP0005171_absent_coat_pigmentation2.71743809
6MP0008260_abnormal_autophagy2.71589028
7MP0005058_abnormal_lysosome_morphology2.66309388
8MP0003724_increased_susceptibility_to2.65457825
9MP0003300_gastrointestinal_ulcer2.64510095
10MP0006082_CNS_inflammation2.63894143
11MP0003880_abnormal_central_pattern2.63375563
12MP0001905_abnormal_dopamine_level2.51549759
13MP0002166_altered_tumor_susceptibility2.50621457
14MP0003806_abnormal_nucleotide_metabolis2.48047337
15MP0003136_yellow_coat_color2.43852896
16MP0003195_calcinosis2.27899084
17MP0008057_abnormal_DNA_replication2.26664936
18MP0003329_amyloid_beta_deposits2.25330481
19MP0002006_tumorigenesis2.22457576
20MP0004264_abnormal_extraembryonic_tissu2.19474814
21MP0004147_increased_porphyrin_level2.05066928
22MP0008438_abnormal_cutaneous_collagen2.03504861
23MP0004043_abnormal_pH_regulation2.01470659
24MP0004742_abnormal_vestibular_system1.97538408
25MP0009697_abnormal_copulation1.95682008
26MP0010352_gastrointestinal_tract_polyps1.90831901
27MP0000569_abnormal_digit_pigmentation1.90391306
28MP0002877_abnormal_melanocyte_morpholog1.89782647
29MP0003252_abnormal_bile_duct1.85405837
30MP0004381_abnormal_hair_follicle1.82878206
31MP0004270_analgesia1.80708823
32MP0003566_abnormal_cell_adhesion1.80449708
33MP0002148_abnormal_hypersensitivity_rea1.79254312
34MP0005408_hypopigmentation1.78001162
35MP0001529_abnormal_vocalization1.77702324
36MP0005451_abnormal_body_composition1.77408203
37MP0005023_abnormal_wound_healing1.76419625
38MP0009785_altered_susceptibility_to1.74141664
39MP0005076_abnormal_cell_differentiation1.74044208
40MP0000383_abnormal_hair_follicle1.73404064
41MP0000604_amyloidosis1.72141835
42MP0003634_abnormal_glial_cell1.71386592
43MP0003191_abnormal_cellular_cholesterol1.68520683
44MP0004883_abnormal_blood_vessel1.68074327
45MP0005670_abnormal_white_adipose1.67236185
46MP0005409_darkened_coat_color1.66908744
47MP0005187_abnormal_penis_morphology1.63575726
48MP0010678_abnormal_skin_adnexa1.60880841
49MP0001851_eye_inflammation1.57917573
50MP0005083_abnormal_biliary_tract1.57150185
51MP0003828_pulmonary_edema1.57093960
52MP0003632_abnormal_nervous_system1.56644742
53MP0004142_abnormal_muscle_tone1.55711622
54MP0003436_decreased_susceptibility_to1.54516073
55MP0004885_abnormal_endolymph1.51122051
56MP0003091_abnormal_cell_migration1.50400765
57MP0002419_abnormal_innate_immunity1.46414023
58MP0004808_abnormal_hematopoietic_stem1.45175687
59MP0003045_fibrosis1.36628012
60MP0002295_abnormal_pulmonary_circulatio1.36318723
61MP0000685_abnormal_immune_system1.35687789
62MP0000566_synostosis1.33809498
63MP0002272_abnormal_nervous_system1.31981304
64MP0003186_abnormal_redox_activity1.31798517
65MP0002229_neurodegeneration1.28799996
66MP0000343_altered_response_to1.27994554
67MP0002396_abnormal_hematopoietic_system1.27610190
68MP0004272_abnormal_basement_membrane1.25834050
69MP0001800_abnormal_humoral_immune1.24504682
70MP0001545_abnormal_hematopoietic_system1.24298814
71MP0005397_hematopoietic_system_phenotyp1.24298814
72MP0001873_stomach_inflammation1.23205082
73MP0001486_abnormal_startle_reflex1.22634438
74MP0009278_abnormal_bone_marrow1.21976542
75MP0005000_abnormal_immune_tolerance1.21749250
76MP0008875_abnormal_xenobiotic_pharmacok1.21167489
77MP0001661_extended_life_span1.20843608
78MP0002064_seizures1.19600094
79MP0001542_abnormal_bone_strength1.19556227
80MP0004947_skin_inflammation1.19483136
81MP0002405_respiratory_system_inflammati1.17536238
82MP0005164_abnormal_response_to1.17270917
83MP0001845_abnormal_inflammatory_respons1.14812123
84MP0003631_nervous_system_phenotype1.14687041
85MP0003656_abnormal_erythrocyte_physiolo1.13203701
86MP0002928_abnormal_bile_duct1.13164809
87MP0005025_abnormal_response_to1.11435550
88MP0010234_abnormal_vibrissa_follicle1.10996483
89MP0002060_abnormal_skin_morphology1.10579993
90MP0000465_gastrointestinal_hemorrhage1.10202351
91MP0002168_other_aberrant_phenotype1.09771585
92MP0001485_abnormal_pinna_reflex1.09273282
93MP0001188_hyperpigmentation1.07763916
94MP0005671_abnormal_response_to1.07668170
95MP0000015_abnormal_ear_pigmentation1.06014783
96MP0010155_abnormal_intestine_physiology1.05240921
97MP0005410_abnormal_fertilization1.04534484
98MP0000371_diluted_coat_color1.04256208
99MP0002933_joint_inflammation1.04127786
100MP0001533_abnormal_skeleton_physiology1.03782751
101MP0000372_irregular_coat_pigmentation1.03272477
102MP0009840_abnormal_foam_cell1.02985504
103MP0001835_abnormal_antigen_presentation1.02708888
104MP0002138_abnormal_hepatobiliary_system1.02534542
105MP0001958_emphysema1.01571269
106MP0001346_abnormal_lacrimal_gland1.00681347
107MP0006054_spinal_hemorrhage0.99087278
108MP0000858_altered_metastatic_potential0.96839647
109MP0003763_abnormal_thymus_physiology0.96664380
110MP0001853_heart_inflammation0.95214400
111MP0002132_abnormal_respiratory_system0.95186562
112MP0000627_abnormal_mammary_gland0.94589563
113MP0001790_abnormal_immune_system0.94308214
114MP0005387_immune_system_phenotype0.94308214
115MP0000427_abnormal_hair_cycle0.94166651
116MP0003633_abnormal_nervous_system0.94070504
117MP0005464_abnormal_platelet_physiology0.93218231
118MP0005275_abnormal_skin_tensile0.92065253
119MP0003866_abnormal_defecation0.91639935
120MP0003448_altered_tumor_morphology0.90837003
121MP0003075_altered_response_to0.89473346
122MP0003943_abnormal_hepatobiliary_system0.89367445
123MP0002420_abnormal_adaptive_immunity0.88479996
124MP0001819_abnormal_immune_cell0.88120517
125MP0000767_abnormal_smooth_muscle0.87183185
126MP0002723_abnormal_immune_serum0.86860408
127MP0002876_abnormal_thyroid_physiology0.86536082
128MP0001440_abnormal_grooming_behavior0.85565893
129MP0009765_abnormal_xenobiotic_induced0.85532955
130MP0002098_abnormal_vibrissa_morphology0.84447682
131MP0005085_abnormal_gallbladder_physiolo0.83725690
132MP0005075_abnormal_melanosome_morpholog0.83503470
133MP0000647_abnormal_sebaceous_gland0.81416910
134MP0001879_abnormal_lymphatic_vessel0.81175553
135MP0002332_abnormal_exercise_endurance0.79929997
136MP0005332_abnormal_amino_acid0.79424133
137MP0003172_abnormal_lysosome_physiology0.79047905
138MP0005376_homeostasis/metabolism_phenot0.78960488
139MP0000249_abnormal_blood_vessel0.78854908
140MP0005166_decreased_susceptibility_to0.78639896
141MP0003183_abnormal_peptide_metabolism0.78154716
142MP0009046_muscle_twitch0.78062689
143MP0005310_abnormal_salivary_gland0.77276112
144MP0002734_abnormal_mechanical_nocicepti0.76691944
145MP0003303_peritoneal_inflammation0.76661787
146MP0009764_decreased_sensitivity_to0.76427586
147MP0005365_abnormal_bile_salt0.75706583
148MP0004134_abnormal_chest_morphology0.74971009
149MP0003868_abnormal_feces_composition0.73967996
150MP0002896_abnormal_bone_mineralization0.73510667
151MP0005388_respiratory_system_phenotype0.73391477
152MP0002133_abnormal_respiratory_system0.73391477
153MP0001963_abnormal_hearing_physiology0.73103408
154MP0001501_abnormal_sleep_pattern0.72906469
155MP0005390_skeleton_phenotype0.72560019
156MP0001756_abnormal_urination0.72068722
157MP0001666_abnormal_nutrient_absorption0.71873347
158MP0009333_abnormal_splenocyte_physiolog0.71700562
159MP0009780_abnormal_chondrocyte_physiolo0.71645724
160MP0001243_abnormal_dermal_layer0.71056495
161MP0009745_abnormal_behavioral_response0.70866929
162MP0008469_abnormal_protein_level0.70532785
163MP0000778_abnormal_nervous_system0.68315208
164MP0001664_abnormal_digestion0.67940998
165MP0002998_abnormal_bone_remodeling0.66736243
166MP0001177_atelectasis0.65581849
167MP0003718_maternal_effect0.65377013
168MP0002452_abnormal_antigen_presenting0.64847713

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of the lateral corticospinal tracts (HP:0002314)5.24038035
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.24038035
3Neurofibrillary tangles (HP:0002185)4.93208865
4Parakeratosis (HP:0001036)4.70989829
5Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.41726225
6Absent frontal sinuses (HP:0002688)3.94662231
7Sensory axonal neuropathy (HP:0003390)3.74590222
8Follicular hyperkeratosis (HP:0007502)3.55801752
9Abnormality of the nasal septum (HP:0000419)3.45495893
10Abnormality of glycolysis (HP:0004366)3.44287036
11Increased serum pyruvate (HP:0003542)3.44287036
12Alopecia of scalp (HP:0002293)3.40170792
13Abnormality of the corticospinal tract (HP:0002492)3.32614334
14Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.32144614
15Subacute progressive viral hepatitis (HP:0006572)3.16056988
16Aortic aneurysm (HP:0004942)3.15035737
17Congenital ichthyosiform erythroderma (HP:0007431)3.14248280
18Cerebral inclusion bodies (HP:0100314)3.14093782
19Autoamputation (HP:0001218)3.14036013
20Hepatosplenomegaly (HP:0001433)3.05140912
21Orchitis (HP:0100796)3.05004652
22Cerebral hypomyelination (HP:0006808)3.03692582
23Malnutrition (HP:0004395)3.01275727
24Scanning speech (HP:0002168)2.99886304
25Prolonged neonatal jaundice (HP:0006579)2.97520328
26Aortic dissection (HP:0002647)2.96729751
27Spinal cord lesions (HP:0100561)2.94913279
28Syringomyelia (HP:0003396)2.94913279
29Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.88781978
30Arterial tortuosity (HP:0005116)2.87607608
31Axonal loss (HP:0003447)2.82654707
32Mitral stenosis (HP:0001718)2.80181882
33Peripheral hypomyelination (HP:0007182)2.79781647
34Onion bulb formation (HP:0003383)2.79501162
35Spondylolisthesis (HP:0003302)2.77891730
36Micronodular cirrhosis (HP:0001413)2.77878594
37Stomatitis (HP:0010280)2.76601596
38Eczematoid dermatitis (HP:0000976)2.71634387
39Spastic paraparesis (HP:0002313)2.70371561
40Retrobulbar optic neuritis (HP:0100654)2.66180934
41Optic neuritis (HP:0100653)2.66180934
42Myositis (HP:0100614)2.65225220
43Sparse lateral eyebrow (HP:0005338)2.63665904
44Recurrent gram-negative bacterial infections (HP:0005420)2.61830540
453-Methylglutaconic aciduria (HP:0003535)2.61165164
46Vacuolated lymphocytes (HP:0001922)2.60354601
47Stridor (HP:0010307)2.57625036
48Segmental peripheral demyelination/remyelination (HP:0003481)2.56788712
49Abnormality of the frontal sinuses (HP:0002687)2.52349070
50Slow saccadic eye movements (HP:0000514)2.52011828
51Increased neuronal autofluorescent lipopigment (HP:0002074)2.50388137
52Renal Fanconi syndrome (HP:0001994)2.48948611
53Abnormality of macrophages (HP:0004311)2.48852990
54J-shaped sella turcica (HP:0002680)2.47228370
55Submucous cleft hard palate (HP:0000176)2.46244445
56Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.43727585
57Cerebral hemorrhage (HP:0001342)2.41290759
58Leukodystrophy (HP:0002415)2.41138296
59Abnormal auditory evoked potentials (HP:0006958)2.40783582
60Vascular tortuosity (HP:0004948)2.39941729
61Osteolytic defects of the hand bones (HP:0009699)2.34163697
62Osteolytic defects of the phalanges of the hand (HP:0009771)2.34163697
63Purpura (HP:0000979)2.33209168
64Patchy hypopigmentation of hair (HP:0011365)2.33167220
65Premature skin wrinkling (HP:0100678)2.29747600
66Asymmetry of the thorax (HP:0001555)2.29645542
67Generalized hypopigmentation of hair (HP:0011358)2.28866265
68Interstitial pulmonary disease (HP:0006530)2.28699235
69Akinesia (HP:0002304)2.26617622
70Methylmalonic acidemia (HP:0002912)2.24611480
71Autoimmune hemolytic anemia (HP:0001890)2.24039897
72Abnormality of the pericardium (HP:0001697)2.23035309
73Abnormality of the phalanges of the 2nd finger (HP:0009541)2.22752775
74Premature rupture of membranes (HP:0001788)2.22500416
75Metabolic alkalosis (HP:0200114)2.21056697
76Coarse hair (HP:0002208)2.18745858
77Deep philtrum (HP:0002002)2.18599976
78Clumsiness (HP:0002312)2.18556938
79White forelock (HP:0002211)2.18291552
80Ectropion (HP:0000656)2.17598773
81Mucopolysacchariduria (HP:0008155)2.16322222
82Urinary glycosaminoglycan excretion (HP:0003541)2.16322222
83Gingivitis (HP:0000230)2.13239255
84Lip pit (HP:0100267)2.12895461
85Adrenal hypoplasia (HP:0000835)2.12676625
86Papillary thyroid carcinoma (HP:0002895)2.11022457
87Hypokalemic alkalosis (HP:0001949)2.10845013
88Delayed closure of the anterior fontanelle (HP:0001476)2.09213117
89Stomach cancer (HP:0012126)2.08693105
90Erythroderma (HP:0001019)2.07432978
91Peritonitis (HP:0002586)2.05961209
92Supranuclear gaze palsy (HP:0000605)2.04239652
93Aneurysm (HP:0002617)2.03337903
94Paraparesis (HP:0002385)2.03326761
95Glomerulonephritis (HP:0000099)2.03004583
96Abnormality of aromatic amino acid family metabolism (HP:0004338)2.02761954
97CNS hypomyelination (HP:0003429)2.02442683
98Recurrent bacterial skin infections (HP:0005406)2.02065059
99Abnormality of polysaccharide metabolism (HP:0011012)2.00272201
100Abnormality of glycosaminoglycan metabolism (HP:0004371)2.00272201
101Abnormality of mucopolysaccharide metabolism (HP:0011020)2.00272201
102Curly hair (HP:0002212)1.99671753
103Episodic fever (HP:0001954)1.99583240
104Neoplasm of the tracheobronchial system (HP:0100552)1.98579496
105Steatorrhea (HP:0002570)1.98573836
106Hepatocellular necrosis (HP:0001404)1.98024814
107Fair hair (HP:0002286)1.97701204
108Spastic tetraparesis (HP:0001285)1.97215360
109Striae distensae (HP:0001065)1.95817461
110Spastic gait (HP:0002064)1.95690861
111Increased CSF protein (HP:0002922)1.95505684
112Recurrent abscess formation (HP:0002722)1.95257516
113Bilateral sensorineural hearing impairment (HP:0008619)1.94673248
114Infantile muscular hypotonia (HP:0008947)1.94064049
115Thickened helices (HP:0000391)1.93709745
116Thick nail (HP:0001805)1.93596618
117Periodontitis (HP:0000704)1.93328399
118Cervical subluxation (HP:0003308)1.92965557
119Gastrointestinal infarctions (HP:0005244)1.92586716
120Intention tremor (HP:0002080)1.92584769
121Abnormality of the sella turcica (HP:0002679)1.91646988
122Cone-rod dystrophy (HP:0000548)1.90970028
123Increased cerebral lipofuscin (HP:0011813)1.90167976
124Split foot (HP:0001839)1.89924562
125Hypomagnesemia (HP:0002917)1.88246411
126Acute necrotizing encephalopathy (HP:0006965)1.87583664
127Abnormality of the common coagulation pathway (HP:0010990)1.86928415
128Mitochondrial inheritance (HP:0001427)1.86673023
129Morphological abnormality of the inner ear (HP:0011390)1.86233900
130Conical tooth (HP:0000698)1.85915918
131Abnormality of renal resorption (HP:0011038)1.84918183
132Deformed sella turcica (HP:0002681)1.84462038
133Abnormal hair whorl (HP:0010721)1.84096025
134Retinal dysplasia (HP:0007973)1.83800837
135Increased circulating renin level (HP:0000848)1.83510101
136Vascular calcification (HP:0004934)1.83014609
137Tetraparesis (HP:0002273)1.82956213
138Alacrima (HP:0000522)1.82806473
139Hypophosphatemic rickets (HP:0004912)1.80994174
140Keratitis (HP:0000491)1.79394282
141Dysmetria (HP:0001310)1.79273044
142Recurrent skin infections (HP:0001581)1.78483381
143Pulmonary infiltrates (HP:0002113)1.78287615
144Amelogenesis imperfecta (HP:0000705)1.78273452
145Albinism (HP:0001022)1.77788499
146Aortic regurgitation (HP:0001659)1.77775193
147Abnormality of the axillary hair (HP:0100134)1.77235269
148Abnormality of secondary sexual hair (HP:0009888)1.77235269
149Abnormality of T cell number (HP:0011839)1.77135054
150Ileus (HP:0002595)1.76838978
151Hyperkalemia (HP:0002153)1.76358976
152Anhidrosis (HP:0000970)1.75792814
153Cupped ear (HP:0000378)1.74848934
154Abnormal delayed hypersensitivity skin test (HP:0002963)1.73793148
155Right ventricular cardiomyopathy (HP:0011663)1.73390621
156Poor speech (HP:0002465)1.73268434
157Acute myeloid leukemia (HP:0004808)1.73197872
158Hemorrhage of the eye (HP:0011885)1.71913181
159Diminished movement (HP:0002374)1.71441565
160Neuroendocrine neoplasm (HP:0100634)1.71010221
161Progressive neurologic deterioration (HP:0002344)1.70902006
162Barrel-shaped chest (HP:0001552)1.70363090
163Muscle fiber splitting (HP:0003555)1.70228242
164Autoimmune thrombocytopenia (HP:0001973)1.69620562
165Opisthotonus (HP:0002179)1.69551313
166Abnormality of the umbilical cord (HP:0010881)1.69250502
167Intrahepatic cholestasis (HP:0001406)1.69053428
168Mediastinal lymphadenopathy (HP:0100721)1.68433631
169Abolished electroretinogram (ERG) (HP:0000550)1.68142906
170Synostosis involving the elbow (HP:0003938)1.68013033
171Humeroradial synostosis (HP:0003041)1.68013033
172Viral hepatitis (HP:0006562)1.67601123
173Elevated erythrocyte sedimentation rate (HP:0003565)1.67409323
174Narrow palate (HP:0000189)1.66814155
175Amyloidosis (HP:0011034)1.66658862
176Cardiovascular calcification (HP:0011915)1.66044610
177Hypoplasia of the iris (HP:0007676)1.65830415
178Nonprogressive disorder (HP:0003680)1.65646424
179Alveolar cell carcinoma (HP:0006519)1.65425439
180Cerebral aneurysm (HP:0004944)1.64152890
181Acute encephalopathy (HP:0006846)1.62804288
182Keratoconjunctivitis sicca (HP:0001097)1.62665136
183Cheilitis (HP:0100825)1.61765334
184Large for gestational age (HP:0001520)1.60767920
185Hemoptysis (HP:0002105)1.59475438
186Osteomyelitis (HP:0002754)1.58787037
187Chronic diarrhea (HP:0002028)1.58574407
188Myocardial infarction (HP:0001658)1.58134939
189Gingival bleeding (HP:0000225)1.58107629
190Keratoconjunctivitis (HP:0001096)1.57993705

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK395.33773252
2OXSR14.51014265
3FRK3.47169004
4PBK3.17855460
5MST1R3.11434427
6MST42.72683875
7EPHB12.69422835
8BCR2.55639710
9MAPKAPK52.52545937
10CDK192.33455545
11CASK2.29712826
12MET2.00208493
13PKN11.99180080
14NEK61.98123818
15MAP3K21.84289338
16TYK21.80402851
17CSNK1G31.78933434
18MAP3K31.78905303
19LIMK11.76525771
20WNK41.76449807
21FER1.72107994
22JAK11.69760762
23BMPR1B1.65600247
24CSNK1A1L1.65100473
25MAP3K141.60240004
26MUSK1.57921398
27ERN11.55998810
28FGFR21.50145141
29ACVR1B1.49826654
30TESK21.49069061
31BMPR21.48595804
32SCYL21.44251011
33CSNK1G11.40614851
34CAMK2B1.36175376
35FGFR31.35949373
36TXK1.31612145
37CDK61.31299187
38TRPM71.30560608
39WNK11.30468338
40FGR1.29693200
41BRSK21.27716094
42PRPF4B1.24187642
43CSNK1G21.20421775
44TGFBR21.17958473
45EPHA31.17501491
46CLK11.16424439
47TNIK1.16333639
48TAOK31.15389855
49INSRR1.14828414
50SGK2231.13428011
51SGK4941.13428011
52FGFR41.11789135
53CHUK1.09774012
54IRAK31.08309940
55PDGFRB1.08211766
56CAMK2D1.06933242
57EIF2AK31.06685037
58SIK11.04000229
59ERBB41.03321047
60AKT31.00577767
61MKNK10.99177300
62RPS6KB20.97890623
63LMTK20.96024584
64PIK3CA0.94894965
65STK38L0.93899389
66CAMK2G0.93183210
67MAPKAPK30.93045327
68ROCK20.91251835
69MAPK110.88353179
70PRKCQ0.86948498
71NEK90.85763070
72PRKCE0.85138011
73CDC42BPA0.82867954
74RPS6KA50.80790165
75IKBKE0.79406629
76PTK20.78957387
77ARAF0.78812983
78EPHA20.78786796
79JAK20.77050467
80IKBKB0.76831049
81PKN20.76283963
82ZAP700.76125203
83ADRBK20.76088461
84HIPK20.73067639
85PAK40.73003279
86PIM20.72702640
87NLK0.70590094
88STK380.70086149
89PLK20.69532507
90RIPK40.69329295
91IRAK40.67746648
92STK160.67630319
93GRK70.67502233
94CAMK2A0.67442712
95EIF2AK10.66583787
96MAP3K120.65180240
97MAP2K30.61877199
98JAK30.61693324
99NTRK10.61366144
100NUAK10.60543851
101PIK3CG0.60515592
102STK30.59057996
103MTOR0.59054325
104BRD40.58068074
105ERBB30.57796212
106MAP2K10.57158613
107MAPKAPK20.56325213
108HCK0.56251680
109SIK30.55701339
110PDGFRA0.54839484
111PDPK10.53656975
112PDK20.53443563
113CDK120.53427907
114MYLK0.52604743
115PDK10.51967537
116ABL10.51566640
117MAP3K10.51293224
118NME10.51203544
119BUB10.51114740
120ADRBK10.51009125
121FGFR10.50828820
122MAP3K70.50646875
123PAK20.48849989
124MAPK70.48444014
125STK100.48204848
126MAP3K130.48182753
127EPHA40.47738349
128GRK10.47524638
129LCK0.45182465
130KIT0.44399309
131CSNK1A10.44234180
132PTK60.43238684
133STK240.41404142
134PRKG10.41147942
135DYRK20.40116444
136SGK20.39988773
137TTN0.39670592
138IRAK10.39364754
139SGK30.38960413
140TEC0.38753913
141FYN0.37193343
142PAK30.36969925
143DAPK30.36124685
144CDK140.35600294
145TBK10.35138771
146YES10.35011484
147CSK0.34271533
148ZAK0.34268794
149PTK2B0.33116263
150PRKCD0.32802777
151PRKACB0.31850271
152CDK50.31731788
153GSK3A0.31594294
154ITK0.30747270
155ABL20.30353458
156UHMK10.30343506
157BLK0.30101479
158CSF1R0.29841347
159MELK0.29765018
160IRAK20.28647526
161VRK10.28179302
162STK40.25649148

Predicted pathways (KEGG)

RankGene SetZ-score
1Steroid biosynthesis_Homo sapiens_hsa001004.26283752
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.23884339
3Fatty acid elongation_Homo sapiens_hsa000624.04322740
4Vitamin B6 metabolism_Homo sapiens_hsa007503.13209984
5Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.98811877
6Protein export_Homo sapiens_hsa030602.89735162
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.67922444
8Ether lipid metabolism_Homo sapiens_hsa005652.45992540
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.37892980
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.35902532
11Sulfur metabolism_Homo sapiens_hsa009202.14083122
12Rheumatoid arthritis_Homo sapiens_hsa053232.09743875
13Sphingolipid metabolism_Homo sapiens_hsa006002.05511864
14Histidine metabolism_Homo sapiens_hsa003402.00224040
15Oxidative phosphorylation_Homo sapiens_hsa001901.96119874
16Osteoclast differentiation_Homo sapiens_hsa043801.81383843
17SNARE interactions in vesicular transport_Homo sapiens_hsa041301.77797658
18Collecting duct acid secretion_Homo sapiens_hsa049661.74597224
19Dorso-ventral axis formation_Homo sapiens_hsa043201.73718091
20TNF signaling pathway_Homo sapiens_hsa046681.71696429
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.66093277
22Jak-STAT signaling pathway_Homo sapiens_hsa046301.65975651
23Malaria_Homo sapiens_hsa051441.61019404
24Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.58111028
25Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.51792248
26Autoimmune thyroid disease_Homo sapiens_hsa053201.51442200
27Graft-versus-host disease_Homo sapiens_hsa053321.51255586
28Glycosaminoglycan degradation_Homo sapiens_hsa005311.47700236
29Measles_Homo sapiens_hsa051621.44501855
30AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.41909740
31Allograft rejection_Homo sapiens_hsa053301.39338526
32Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.37131772
33Glutathione metabolism_Homo sapiens_hsa004801.36915732
34Influenza A_Homo sapiens_hsa051641.35179824
35Phagosome_Homo sapiens_hsa041451.34332926
36Folate biosynthesis_Homo sapiens_hsa007901.34330158
37Vibrio cholerae infection_Homo sapiens_hsa051101.34157027
38Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.31917571
39Arachidonic acid metabolism_Homo sapiens_hsa005901.31112363
40Insulin resistance_Homo sapiens_hsa049311.30606242
41TGF-beta signaling pathway_Homo sapiens_hsa043501.29637558
42Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.27960560
43Vitamin digestion and absorption_Homo sapiens_hsa049771.27477901
44Lysosome_Homo sapiens_hsa041421.26658962
45Hepatitis B_Homo sapiens_hsa051611.25612085
46FoxO signaling pathway_Homo sapiens_hsa040681.23155958
47Chemical carcinogenesis_Homo sapiens_hsa052041.22682527
48Small cell lung cancer_Homo sapiens_hsa052221.21765104
49Chronic myeloid leukemia_Homo sapiens_hsa052201.19747138
50Linoleic acid metabolism_Homo sapiens_hsa005911.19687497
51Proteoglycans in cancer_Homo sapiens_hsa052051.19293632
52Prostate cancer_Homo sapiens_hsa052151.18305070
53Toxoplasmosis_Homo sapiens_hsa051451.17507923
54ABC transporters_Homo sapiens_hsa020101.16192571
55Nitrogen metabolism_Homo sapiens_hsa009101.16118148
56Steroid hormone biosynthesis_Homo sapiens_hsa001401.14684387
57Proteasome_Homo sapiens_hsa030501.13828594
58Acute myeloid leukemia_Homo sapiens_hsa052211.12280759
59Parkinsons disease_Homo sapiens_hsa050121.10454908
60alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.10102079
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.09154742
62Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.08082536
63Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.07747489
64Alzheimers disease_Homo sapiens_hsa050101.05872079
65Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.05302614
66Adherens junction_Homo sapiens_hsa045201.04629586
67Regulation of autophagy_Homo sapiens_hsa041401.03094382
68HIF-1 signaling pathway_Homo sapiens_hsa040661.01734844
69Pancreatic cancer_Homo sapiens_hsa052121.01336384
70Asthma_Homo sapiens_hsa053101.01236037
71Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.00631382
72Peroxisome_Homo sapiens_hsa041460.98464687
73Amoebiasis_Homo sapiens_hsa051460.96363056
74Transcriptional misregulation in cancer_Homo sapiens_hsa052020.96228283
75Focal adhesion_Homo sapiens_hsa045100.95572009
76Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.95556986
77mTOR signaling pathway_Homo sapiens_hsa041500.93817831
78Bladder cancer_Homo sapiens_hsa052190.91934710
79Staphylococcus aureus infection_Homo sapiens_hsa051500.90760002
80Non-small cell lung cancer_Homo sapiens_hsa052230.89923497
81Arginine and proline metabolism_Homo sapiens_hsa003300.89276679
82Platelet activation_Homo sapiens_hsa046110.87267436
83Apoptosis_Homo sapiens_hsa042100.86617027
84Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.86005055
85Fatty acid biosynthesis_Homo sapiens_hsa000610.84657742
86Circadian rhythm_Homo sapiens_hsa047100.83180899
87Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.82913940
88Chemokine signaling pathway_Homo sapiens_hsa040620.81781063
89Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.77892273
90B cell receptor signaling pathway_Homo sapiens_hsa046620.77326853
91Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.76942560
92NOD-like receptor signaling pathway_Homo sapiens_hsa046210.76853126
93Thyroid cancer_Homo sapiens_hsa052160.76750894
94Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.76097389
95Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.75988328
96Primary bile acid biosynthesis_Homo sapiens_hsa001200.74789497
97MicroRNAs in cancer_Homo sapiens_hsa052060.74481640
98Pertussis_Homo sapiens_hsa051330.73416363
99N-Glycan biosynthesis_Homo sapiens_hsa005100.73330551
100Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.73182255
101Herpes simplex infection_Homo sapiens_hsa051680.71697763
102Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.71114116
103Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.70867258
104Mineral absorption_Homo sapiens_hsa049780.69822066
105Intestinal immune network for IgA production_Homo sapiens_hsa046720.69648115
106Retinol metabolism_Homo sapiens_hsa008300.68584700
107Prolactin signaling pathway_Homo sapiens_hsa049170.68547145
108Viral carcinogenesis_Homo sapiens_hsa052030.68212177
109African trypanosomiasis_Homo sapiens_hsa051430.68077016
110Endometrial cancer_Homo sapiens_hsa052130.64551857
111Melanoma_Homo sapiens_hsa052180.64143318
112Hematopoietic cell lineage_Homo sapiens_hsa046400.63911031
113Salmonella infection_Homo sapiens_hsa051320.63004437
114Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.62876861
115Complement and coagulation cascades_Homo sapiens_hsa046100.62585894
116Other glycan degradation_Homo sapiens_hsa005110.60760707
117ErbB signaling pathway_Homo sapiens_hsa040120.60581159
118Butanoate metabolism_Homo sapiens_hsa006500.59920136
119PI3K-Akt signaling pathway_Homo sapiens_hsa041510.59084408
120NF-kappa B signaling pathway_Homo sapiens_hsa040640.58999161
121Metabolic pathways_Homo sapiens_hsa011000.58437331
122Choline metabolism in cancer_Homo sapiens_hsa052310.56515243
123Systemic lupus erythematosus_Homo sapiens_hsa053220.55991823
124p53 signaling pathway_Homo sapiens_hsa041150.55217760
125Glioma_Homo sapiens_hsa052140.54788167
126Glycerophospholipid metabolism_Homo sapiens_hsa005640.54083164
127T cell receptor signaling pathway_Homo sapiens_hsa046600.53829218
128RNA polymerase_Homo sapiens_hsa030200.53411271
129Fatty acid metabolism_Homo sapiens_hsa012120.53108146
130Inositol phosphate metabolism_Homo sapiens_hsa005620.52305753
131Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51687322
132Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.50978197
133Regulation of actin cytoskeleton_Homo sapiens_hsa048100.49125051
134Serotonergic synapse_Homo sapiens_hsa047260.47962943
135Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.47011039
136Fructose and mannose metabolism_Homo sapiens_hsa000510.46868145
137Axon guidance_Homo sapiens_hsa043600.45898410
138Phosphatidylinositol signaling system_Homo sapiens_hsa040700.45581457
139Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.44763750
140Sphingolipid signaling pathway_Homo sapiens_hsa040710.44093261
141Pentose and glucuronate interconversions_Homo sapiens_hsa000400.43909992
142Tyrosine metabolism_Homo sapiens_hsa003500.43156568
143Propanoate metabolism_Homo sapiens_hsa006400.42795945
144Huntingtons disease_Homo sapiens_hsa050160.40810608
145ECM-receptor interaction_Homo sapiens_hsa045120.39134992
146Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.38708488
147Shigellosis_Homo sapiens_hsa051310.38641077
148Ovarian steroidogenesis_Homo sapiens_hsa049130.37092325
149Hepatitis C_Homo sapiens_hsa051600.31314050
150Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.30142748
151Endocytosis_Homo sapiens_hsa041440.29662140
152Renal cell carcinoma_Homo sapiens_hsa052110.28671185
153Toll-like receptor signaling pathway_Homo sapiens_hsa046200.27788642
154RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.27109098
155beta-Alanine metabolism_Homo sapiens_hsa004100.27066860
156Tuberculosis_Homo sapiens_hsa051520.26756780
157Tight junction_Homo sapiens_hsa045300.24924374
158Leishmaniasis_Homo sapiens_hsa051400.24886156
159Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.24809634
160Leukocyte transendothelial migration_Homo sapiens_hsa046700.24494723
161Basal transcription factors_Homo sapiens_hsa030220.23895753
162Legionellosis_Homo sapiens_hsa051340.19608787
163Ras signaling pathway_Homo sapiens_hsa040140.19321062

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