VN1R1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Pheromones are chemical signals that elicit specific behavioral responses and physiologic alterations in recipients of the same species. The protein encoded by this gene is similar to pheromone receptors and is primarily localized to the olfactory mucosa. An alternate splice variant of this gene is thought to exist, but its full length nature has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)4.82494949
2epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.42010312
3behavioral response to nicotine (GO:0035095)4.27445037
4nucleobase catabolic process (GO:0046113)3.99489923
5fucose catabolic process (GO:0019317)3.81118929
6L-fucose metabolic process (GO:0042354)3.81118929
7L-fucose catabolic process (GO:0042355)3.81118929
8protein polyglutamylation (GO:0018095)3.79272471
9* response to pheromone (GO:0019236)3.78054495
10epithelial cilium movement (GO:0003351)3.74553245
11protein K11-linked deubiquitination (GO:0035871)3.63262490
12respiratory chain complex IV assembly (GO:0008535)3.61401217
13regulation of glucokinase activity (GO:0033131)3.61197520
14regulation of hexokinase activity (GO:1903299)3.61197520
15glycosphingolipid biosynthetic process (GO:0006688)3.49279044
16positive regulation of mitochondrial fission (GO:0090141)3.48197241
17cytochrome complex assembly (GO:0017004)3.45461332
18protein complex biogenesis (GO:0070271)3.38546644
19regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.30512823
20nonmotile primary cilium assembly (GO:0035058)3.25397083
21regulation of cilium movement (GO:0003352)3.22281405
22mitochondrial respiratory chain complex assembly (GO:0033108)3.19676422
23axoneme assembly (GO:0035082)3.17885067
24C4-dicarboxylate transport (GO:0015740)3.14244495
25intraciliary transport (GO:0042073)3.08134430
26limb bud formation (GO:0060174)3.04815574
27proline transport (GO:0015824)3.00808720
28detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.00223579
29inositol phosphate catabolic process (GO:0071545)3.00203211
30cornea development in camera-type eye (GO:0061303)2.99111311
31neuronal action potential propagation (GO:0019227)2.92000271
32calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.90274557
33neural tube formation (GO:0001841)2.88537243
34cilium morphogenesis (GO:0060271)2.85770302
35DNA deamination (GO:0045006)2.85452260
36mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.82490312
37mitochondrial respiratory chain complex I assembly (GO:0032981)2.82490312
38NADH dehydrogenase complex assembly (GO:0010257)2.82490312
39ovulation cycle (GO:0042698)2.80957541
40regulation of telomere maintenance (GO:0032204)2.78697317
41regulation of mitochondrial fission (GO:0090140)2.78682283
42cilium movement (GO:0003341)2.76913229
43startle response (GO:0001964)2.76576417
44negative regulation of cytosolic calcium ion concentration (GO:0051481)2.76185079
45head development (GO:0060322)2.75223110
46photoreceptor cell maintenance (GO:0045494)2.75012814
47platelet dense granule organization (GO:0060155)2.74176319
48negative regulation of synaptic transmission, GABAergic (GO:0032229)2.74017210
49postsynaptic membrane organization (GO:0001941)2.71262215
50water-soluble vitamin biosynthetic process (GO:0042364)2.70594639
51reflex (GO:0060004)2.68131511
52regulation of action potential (GO:0098900)2.67319638
53indolalkylamine metabolic process (GO:0006586)2.67013834
54amine catabolic process (GO:0009310)2.65244048
55cellular biogenic amine catabolic process (GO:0042402)2.65244048
56cilium organization (GO:0044782)2.62320321
57nephron epithelium morphogenesis (GO:0072088)2.62157714
58nephron tubule morphogenesis (GO:0072078)2.62157714
59regulation of neurotransmitter uptake (GO:0051580)2.61716893
60gamma-aminobutyric acid transport (GO:0015812)2.61054273
61somite development (GO:0061053)2.59385980
62membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.58969088
63negative regulation of axon guidance (GO:1902668)2.58568724
64piRNA metabolic process (GO:0034587)2.57517736
65dopamine transport (GO:0015872)2.57491644
66negative regulation of neurological system process (GO:0031645)2.57157167
67olfactory bulb development (GO:0021772)2.56678194
68cilium assembly (GO:0042384)2.54249226
69phosphorylated carbohydrate dephosphorylation (GO:0046838)2.53412266
70inositol phosphate dephosphorylation (GO:0046855)2.53412266
71behavioral response to ethanol (GO:0048149)2.52683219
72replication fork processing (GO:0031297)2.52193243
73G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.51965233
74ubiquinone biosynthetic process (GO:0006744)2.51743219
75glycerophospholipid catabolic process (GO:0046475)2.50265206
76positive regulation of oligodendrocyte differentiation (GO:0048714)2.50173578
77protein prenylation (GO:0018342)2.48509381
78prenylation (GO:0097354)2.48509381
79negative regulation of telomere maintenance (GO:0032205)2.48389249
80ketone body metabolic process (GO:1902224)2.47210450
81peptidyl-histidine modification (GO:0018202)2.47105691
82retinal ganglion cell axon guidance (GO:0031290)2.46456305
83cellular ketone body metabolic process (GO:0046950)2.44609476
84renal tubule morphogenesis (GO:0061333)2.43890983
85regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.42473521
86ubiquinone metabolic process (GO:0006743)2.41348867
87negative regulation of DNA-dependent DNA replication (GO:2000104)2.40605605
88synaptic transmission, cholinergic (GO:0007271)2.37660400
89acrosome reaction (GO:0007340)2.36936682
90negative regulation of axon extension involved in axon guidance (GO:0048843)2.36200348
91polyol catabolic process (GO:0046174)2.36060678
92regulation of nuclear cell cycle DNA replication (GO:0033262)2.35987429
93retinal cone cell development (GO:0046549)2.35783026
94reciprocal meiotic recombination (GO:0007131)2.35553616
95reciprocal DNA recombination (GO:0035825)2.35553616
96synapse assembly (GO:0007416)2.33452073
97branched-chain amino acid catabolic process (GO:0009083)2.32706311
98regulation of male gonad development (GO:2000018)2.32346776
99anterograde synaptic vesicle transport (GO:0048490)2.30811806
100cell wall macromolecule catabolic process (GO:0016998)2.30609920

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela4.15681788
2IGF1R_20145208_ChIP-Seq_DFB_Human3.30129334
3GBX2_23144817_ChIP-Seq_PC3_Human3.16450883
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.90750319
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.88284078
6VDR_22108803_ChIP-Seq_LS180_Human2.85631335
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.76915666
8FUS_26573619_Chip-Seq_HEK293_Human2.55213241
9EZH2_22144423_ChIP-Seq_EOC_Human2.31292478
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.27831181
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.20383875
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.17064335
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.16910145
14CTBP2_25329375_ChIP-Seq_LNCAP_Human2.16339388
15P300_19829295_ChIP-Seq_ESCs_Human2.14938090
16EWS_26573619_Chip-Seq_HEK293_Human2.14631767
17TAF15_26573619_Chip-Seq_HEK293_Human2.13533548
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.05697710
19CTBP1_25329375_ChIP-Seq_LNCAP_Human1.97246959
20ER_23166858_ChIP-Seq_MCF-7_Human1.90554400
21AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.83322047
22SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.77532896
23PIAS1_25552417_ChIP-Seq_VCAP_Human1.75065222
24PCGF2_27294783_Chip-Seq_ESCs_Mouse1.72997563
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.72381236
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.68687851
27E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.63475700
28SMAD4_21799915_ChIP-Seq_A2780_Human1.61789609
29SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.60904774
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.60896951
31IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.59451835
32CBP_20019798_ChIP-Seq_JUKART_Human1.59451835
33RBPJ_22232070_ChIP-Seq_NCS_Mouse1.57311336
34ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.55416221
35STAT3_23295773_ChIP-Seq_U87_Human1.54859777
36MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.54812285
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.54491107
38BCAT_22108803_ChIP-Seq_LS180_Human1.53709384
39KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.51939914
40AR_25329375_ChIP-Seq_VCAP_Human1.50177212
41UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.50149408
42RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49134983
43NR3C1_21868756_ChIP-Seq_MCF10A_Human1.48654627
44PCGF2_27294783_Chip-Seq_NPCs_Mouse1.48549606
45TCF4_23295773_ChIP-Seq_U87_Human1.48388890
46EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.45156858
47MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.44494139
48GABP_17652178_ChIP-ChIP_JURKAT_Human1.44377795
49OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44004624
50SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43579456
51NOTCH1_21737748_ChIP-Seq_TLL_Human1.42656725
52KLF5_20875108_ChIP-Seq_MESCs_Mouse1.41842508
53EST1_17652178_ChIP-ChIP_JURKAT_Human1.41418254
54SMAD3_21741376_ChIP-Seq_EPCs_Human1.40410881
55SOX2_19829295_ChIP-Seq_ESCs_Human1.40119094
56NANOG_19829295_ChIP-Seq_ESCs_Human1.40119094
57NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.39986786
58TP53_22573176_ChIP-Seq_HFKS_Human1.38410756
59IRF1_19129219_ChIP-ChIP_H3396_Human1.37771464
60TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37436359
61SUZ12_27294783_Chip-Seq_NPCs_Mouse1.33115253
62GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.29078836
63TCF4_22108803_ChIP-Seq_LS180_Human1.28963040
64TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26458501
65ELK1_19687146_ChIP-ChIP_HELA_Human1.25813097
66EZH2_27294783_Chip-Seq_NPCs_Mouse1.25082104
67RUNX2_22187159_ChIP-Seq_PCA_Human1.24124708
68REST_21632747_ChIP-Seq_MESCs_Mouse1.23959724
69MYC_18940864_ChIP-ChIP_HL60_Human1.21011945
70TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.19355978
71FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.17299263
72TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.17115264
73TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16528741
74POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.16528741
75NFE2_27457419_Chip-Seq_LIVER_Mouse1.15338001
76NANOG_18555785_Chip-Seq_ESCs_Mouse1.14950684
77FLI1_21867929_ChIP-Seq_TH2_Mouse1.13094349
78TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12827516
79FOXA1_21572438_ChIP-Seq_LNCaP_Human1.11628942
80RNF2_27304074_Chip-Seq_NSC_Mouse1.10112696
81EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.09141269
82AR_21572438_ChIP-Seq_LNCaP_Human1.08400756
83CBX2_27304074_Chip-Seq_ESCs_Mouse1.07179641
84CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06400082
85FOXA1_25329375_ChIP-Seq_VCAP_Human1.05624435
86FOXA1_27270436_Chip-Seq_PROSTATE_Human1.05624435
87ETV2_25802403_ChIP-Seq_MESCs_Mouse1.05305584
88HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.04240176
89VDR_23849224_ChIP-Seq_CD4+_Human1.02596580
90CRX_20693478_ChIP-Seq_RETINA_Mouse1.02238605
91NCOR_22424771_ChIP-Seq_293T_Human1.01982222
92SMAD4_21741376_ChIP-Seq_EPCs_Human1.01194429
93HTT_18923047_ChIP-ChIP_STHdh_Human1.00068134
94P53_22387025_ChIP-Seq_ESCs_Mouse0.99754648
95CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.99629629
96HOXB7_26014856_ChIP-Seq_BT474_Human0.99504052
97RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.99335745
98SOX2_21211035_ChIP-Seq_LN229_Gbm0.97763320
99E2F1_18555785_Chip-Seq_ESCs_Mouse0.97651467
100REST_18959480_ChIP-ChIP_MESCs_Mouse0.97564716

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003787_abnormal_imprinting3.43902091
2MP0003195_calcinosis3.19673414
3MP0002102_abnormal_ear_morphology3.03353282
4MP0008877_abnormal_DNA_methylation3.00214905
5MP0001986_abnormal_taste_sensitivity2.71913180
6MP0000569_abnormal_digit_pigmentation2.51188494
7MP0005646_abnormal_pituitary_gland2.43065669
8MP0003880_abnormal_central_pattern2.37482094
9MP0001984_abnormal_olfaction2.34418115
10MP0000372_irregular_coat_pigmentation2.26631691
11MP0005551_abnormal_eye_electrophysiolog2.16727440
12MP0003121_genomic_imprinting2.06505402
13MP0006072_abnormal_retinal_apoptosis2.01352708
14MP0003122_maternal_imprinting1.99984102
15MP0003646_muscle_fatigue1.91913938
16MP0002876_abnormal_thyroid_physiology1.91514707
17MP0003136_yellow_coat_color1.85186483
18MP0005253_abnormal_eye_physiology1.81502031
19MP0002638_abnormal_pupillary_reflex1.80026794
20MP0002736_abnormal_nociception_after1.79081796
21MP0002272_abnormal_nervous_system1.72473369
22MP0001968_abnormal_touch/_nociception1.71148704
23MP0004133_heterotaxia1.70205262
24MP0004147_increased_porphyrin_level1.63658830
25MP0009745_abnormal_behavioral_response1.59426517
26MP0001486_abnormal_startle_reflex1.58787821
27MP0005174_abnormal_tail_pigmentation1.58333849
28MP0002938_white_spotting1.56295421
29MP0009046_muscle_twitch1.55888427
30MP0002837_dystrophic_cardiac_calcinosis1.55305169
31MP0005171_absent_coat_pigmentation1.53395715
32MP0005645_abnormal_hypothalamus_physiol1.52362381
33MP0002234_abnormal_pharynx_morphology1.52101145
34MP0005423_abnormal_somatic_nervous1.51170549
35MP0001529_abnormal_vocalization1.50029708
36MP0008872_abnormal_physiological_respon1.49508187
37MP0000015_abnormal_ear_pigmentation1.47079111
38MP0005075_abnormal_melanosome_morpholog1.44450020
39MP0006276_abnormal_autonomic_nervous1.42620977
40MP0005187_abnormal_penis_morphology1.39380159
41MP0000427_abnormal_hair_cycle1.33755297
42MP0005379_endocrine/exocrine_gland_phen1.31752752
43MP0002254_reproductive_system_inflammat1.31264431
44MP0000516_abnormal_urinary_system1.31092832
45MP0005367_renal/urinary_system_phenotyp1.31092832
46MP0004043_abnormal_pH_regulation1.30801647
47MP0004142_abnormal_muscle_tone1.28991631
48MP0000631_abnormal_neuroendocrine_gland1.27764491
49MP0008775_abnormal_heart_ventricle1.26930173
50MP0003011_delayed_dark_adaptation1.25515366
51MP0002572_abnormal_emotion/affect_behav1.22977210
52MP0003635_abnormal_synaptic_transmissio1.22944599
53MP0005386_behavior/neurological_phenoty1.21992414
54MP0004924_abnormal_behavior1.21992414
55MP0008875_abnormal_xenobiotic_pharmacok1.20215898
56MP0002557_abnormal_social/conspecific_i1.18622840
57MP0003718_maternal_effect1.15895595
58MP0001485_abnormal_pinna_reflex1.13501207
59MP0000778_abnormal_nervous_system1.12199066
60MP0002064_seizures1.10912642
61MP0004215_abnormal_myocardial_fiber1.10522874
62MP0004145_abnormal_muscle_electrophysio1.10220810
63MP0002063_abnormal_learning/memory/cond1.09980941
64MP0008995_early_reproductive_senescence1.09262570
65MP0003283_abnormal_digestive_organ1.07916223
66MP0004742_abnormal_vestibular_system1.07090097
67MP0004885_abnormal_endolymph1.06955178
68MP0001293_anophthalmia1.05519030
69MP0002751_abnormal_autonomic_nervous1.01910601
70MP0004859_abnormal_synaptic_plasticity1.01371805
71MP0000613_abnormal_salivary_gland1.00655843
72MP0004484_altered_response_of1.00111290
73MP0001324_abnormal_eye_pigmentation0.99982121
74MP0009780_abnormal_chondrocyte_physiolo0.99961678
75MP0002734_abnormal_mechanical_nocicepti0.99317189
76MP0006054_spinal_hemorrhage0.99305264
77MP0002095_abnormal_skin_pigmentation0.98846120
78MP0002184_abnormal_innervation0.98715869
79MP0004270_analgesia0.98370467
80MP0001501_abnormal_sleep_pattern0.93479400
81MP0003950_abnormal_plasma_membrane0.91992454
82MP0006292_abnormal_olfactory_placode0.91776052
83MP0008058_abnormal_DNA_repair0.90801551
84MP0005195_abnormal_posterior_eye0.89878201
85MP0003172_abnormal_lysosome_physiology0.89548338
86MP0001970_abnormal_pain_threshold0.87859636
87MP0002752_abnormal_somatic_nervous0.87348516
88MP0003119_abnormal_digestive_system0.86810649
89MP0002735_abnormal_chemical_nociception0.86661968
90MP0002067_abnormal_sensory_capabilities0.86487765
91MP0001905_abnormal_dopamine_level0.86481837
92MP0003315_abnormal_perineum_morphology0.84520993
93MP0002163_abnormal_gland_morphology0.84319301
94MP0003123_paternal_imprinting0.83569158
95MP0000383_abnormal_hair_follicle0.81328290
96MP0002090_abnormal_vision0.80029282
97MP0002229_neurodegeneration0.77536551
98MP0000955_abnormal_spinal_cord0.76722248
99MP0008789_abnormal_olfactory_epithelium0.76164109
100MP0002733_abnormal_thermal_nociception0.75648235

Predicted human phenotypes

RankGene SetZ-score
1Molar tooth sign on MRI (HP:0002419)4.00650510
2Abnormality of midbrain morphology (HP:0002418)4.00650510
3Pancreatic fibrosis (HP:0100732)3.99191746
4Pancreatic cysts (HP:0001737)3.93940440
5True hermaphroditism (HP:0010459)3.84669905
6Renal cortical cysts (HP:0000803)3.37529267
7Congenital stationary night blindness (HP:0007642)3.25963166
8Medial flaring of the eyebrow (HP:0010747)3.23093466
9Nephronophthisis (HP:0000090)3.20917345
10Hyperventilation (HP:0002883)3.14713299
11Abnormality of the renal cortex (HP:0011035)2.97609056
12Abnormality of the renal medulla (HP:0100957)2.75994286
13Attenuation of retinal blood vessels (HP:0007843)2.71317692
14Type II lissencephaly (HP:0007260)2.66079018
15Aplasia/Hypoplasia of the spleen (HP:0010451)2.62167629
16Chronic hepatic failure (HP:0100626)2.58406547
17Cystic liver disease (HP:0006706)2.56981365
18Genital tract atresia (HP:0001827)2.55130328
19Gait imbalance (HP:0002141)2.51419503
20Absent/shortened dynein arms (HP:0200106)2.48509784
21Dynein arm defect of respiratory motile cilia (HP:0012255)2.48509784
22Febrile seizures (HP:0002373)2.45883483
23Pendular nystagmus (HP:0012043)2.45825145
24Asplenia (HP:0001746)2.44881191
25Vaginal atresia (HP:0000148)2.44509997
26Congenital primary aphakia (HP:0007707)2.42985682
27Abnormal rod and cone electroretinograms (HP:0008323)2.39726896
28Nephrogenic diabetes insipidus (HP:0009806)2.39101035
29Abolished electroretinogram (ERG) (HP:0000550)2.36857354
30Lissencephaly (HP:0001339)2.36239583
31Absent rod-and cone-mediated responses on ERG (HP:0007688)2.33091994
32Neoplasm of the adrenal cortex (HP:0100641)2.32439735
33Broad-based gait (HP:0002136)2.29772073
34Anencephaly (HP:0002323)2.29213251
35Progressive inability to walk (HP:0002505)2.29173849
36Inability to walk (HP:0002540)2.26128537
37Abnormality of macular pigmentation (HP:0008002)2.26119550
38Drooling (HP:0002307)2.22400668
39Gaze-evoked nystagmus (HP:0000640)2.21758642
40Intestinal atresia (HP:0011100)2.20973368
41Absent speech (HP:0001344)2.19808230
42Aplasia/Hypoplasia of the tongue (HP:0010295)2.19471113
43Hypothermia (HP:0002045)2.17369811
44Abnormality of the labia minora (HP:0012880)2.16962519
45Abnormality of the fovea (HP:0000493)2.13973741
46Decreased central vision (HP:0007663)2.12438894
47Focal seizures (HP:0007359)2.12311178
48Cupped ear (HP:0000378)2.11594767
49Disproportionate short-trunk short stature (HP:0003521)2.11120692
50Progressive cerebellar ataxia (HP:0002073)2.09833825
51Congenital hepatic fibrosis (HP:0002612)2.08991443
52Hyperglycinemia (HP:0002154)2.08130027
53Acute encephalopathy (HP:0006846)2.06952608
54Postaxial foot polydactyly (HP:0001830)2.06220787
55Pachygyria (HP:0001302)2.06133697
56Increased CSF lactate (HP:0002490)2.05320057
57Bifid tongue (HP:0010297)2.04901397
58Optic disc pallor (HP:0000543)2.03314947
59Focal motor seizures (HP:0011153)2.02898863
60Colon cancer (HP:0003003)2.02882735
61Large for gestational age (HP:0001520)2.02390660
62Abnormal drinking behavior (HP:0030082)2.01785764
63Polydipsia (HP:0001959)2.01785764
64Abnormality of the parathyroid morphology (HP:0011766)1.99261703
65Hypoplasia of the fovea (HP:0007750)1.98709283
66Aplasia/Hypoplasia of the fovea (HP:0008060)1.98709283
67Abnormality of aspartate family amino acid metabolism (HP:0010899)1.98317257
68Acute necrotizing encephalopathy (HP:0006965)1.97396691
69Poor coordination (HP:0002370)1.97014465
70Optic nerve hypoplasia (HP:0000609)1.96979603
71Progressive macrocephaly (HP:0004481)1.96397574
72Excessive salivation (HP:0003781)1.95750918
73Postaxial hand polydactyly (HP:0001162)1.95255218
74Anophthalmia (HP:0000528)1.95056818
75Type 2 muscle fiber atrophy (HP:0003554)1.93589455
76Narrow forehead (HP:0000341)1.93375348
77Aqueductal stenosis (HP:0002410)1.93220031
78Hemiparesis (HP:0001269)1.92390415
79Tubular atrophy (HP:0000092)1.91561791
80Male pseudohermaphroditism (HP:0000037)1.91386136
81Abnormality of methionine metabolism (HP:0010901)1.88581137
82Hyperglycinuria (HP:0003108)1.87030196
83Mitochondrial inheritance (HP:0001427)1.86876075
84Cerebellar dysplasia (HP:0007033)1.86714696
85Preaxial hand polydactyly (HP:0001177)1.86225467
86Thyroid-stimulating hormone excess (HP:0002925)1.85412877
87Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.85125068
88Methylmalonic acidemia (HP:0002912)1.84279770
89Albinism (HP:0001022)1.83995083
90Dandy-Walker malformation (HP:0001305)1.83829262
91Sclerocornea (HP:0000647)1.82948503
92Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.82261980
93Protruding tongue (HP:0010808)1.81575974
94Occipital encephalocele (HP:0002085)1.81421442
95Polyphagia (HP:0002591)1.81268163
96Anosmia (HP:0000458)1.79963626
97Supernumerary spleens (HP:0009799)1.76664095
98Abnormal respiratory epithelium morphology (HP:0012253)1.74533701
99Abnormal respiratory motile cilium morphology (HP:0005938)1.74533701
100Decreased circulating renin level (HP:0003351)1.72680032

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.55661176
2TNIK3.18780657
3WNK33.10922236
4MAP4K22.94973245
5NUAK12.77715921
6CASK2.54666896
7PINK12.52428426
8TRIM282.46641497
9ADRBK22.43756030
10BMPR1B2.35330944
11GRK12.09732312
12ACVR1B2.04821555
13MAP3K41.90339217
14EPHA41.85751380
15PAK31.80743446
16TXK1.77068987
17MAPK131.75666758
18MUSK1.63706980
19DYRK21.53275327
20MARK11.45592268
21WNK41.45163684
22ZAK1.44652944
23MKNK21.43428481
24STK391.42965020
25BCR1.41966532
26FGFR21.40686810
27EIF2AK31.37648971
28PLK21.37638151
29STK38L1.36714614
30INSRR1.33649760
31CSNK1G21.32583646
32TAF11.30986666
33MST41.25714967
34OXSR11.22479670
35PLK31.17157993
36ERBB31.16676702
37FER1.15175446
38CSNK1G31.14172198
39MAPKAPK51.13541587
40CSNK1G11.11120342
41PRKCE1.08203296
42MAPKAPK31.07725384
43MAP2K71.05359343
44BRD41.03558835
45MKNK11.01687800
46EPHA31.00263376
47CSNK1A1L0.99363386
48BCKDK0.97430991
49DAPK20.94032393
50PRKCG0.94010756
51VRK20.84835240
52STK160.84036431
53AKT30.83784354
54OBSCN0.82468701
55EIF2AK10.82267654
56PNCK0.81066772
57TAOK30.78765095
58ADRBK10.76572114
59CAMKK20.73205390
60MINK10.72125703
61PHKG10.70968812
62PHKG20.70968812
63IRAK10.70539745
64VRK10.68720790
65NLK0.68003399
66NTRK20.66974813
67NTRK30.62436159
68DYRK30.58516291
69PTK2B0.55252402
70STK110.53853331
71PRKCI0.53772752
72CAMK2A0.50140339
73CAMK10.49984453
74TGFBR10.49532065
75CAMK1G0.46539218
76TSSK60.45831426
77GRK50.44882672
78SRPK10.44093354
79TLK10.44003530
80PRKAA10.43826568
81MAP2K40.41700576
82EIF2AK20.41577546
83CSNK1A10.39527756
84PLK40.39216752
85MAP2K60.38813979
86STK30.38035249
87FLT30.35775665
88DYRK1A0.35372947
89ATM0.34058164
90PRKACB0.34023455
91PRKACA0.34004958
92BRSK20.33956587
93CSNK1D0.33505047
94PRKAA20.33213460
95WEE10.31434334
96LIMK10.31242821
97CDK50.30229637
98PRKCH0.29653785
99MARK30.29303371
100TRPM70.28956925

Predicted pathways (KEGG)

RankGene SetZ-score
1Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.89061320
2Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.75235987
3Phototransduction_Homo sapiens_hsa047442.64253464
4Protein export_Homo sapiens_hsa030602.58939588
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.55855884
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.52015185
7Nicotine addiction_Homo sapiens_hsa050332.29295900
8Butanoate metabolism_Homo sapiens_hsa006502.15580989
9Propanoate metabolism_Homo sapiens_hsa006402.10942635
10Selenocompound metabolism_Homo sapiens_hsa004502.10787724
11Linoleic acid metabolism_Homo sapiens_hsa005912.08944909
12alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.99223948
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.96690068
14Caffeine metabolism_Homo sapiens_hsa002321.90532700
15Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.85759100
16Nitrogen metabolism_Homo sapiens_hsa009101.76313386
17Ether lipid metabolism_Homo sapiens_hsa005651.73176215
18Fanconi anemia pathway_Homo sapiens_hsa034601.69709531
19Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.65298079
20Non-homologous end-joining_Homo sapiens_hsa034501.63693610
21Oxidative phosphorylation_Homo sapiens_hsa001901.61665111
22Basal transcription factors_Homo sapiens_hsa030221.60405988
23Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.55349142
24One carbon pool by folate_Homo sapiens_hsa006701.52807378
25Peroxisome_Homo sapiens_hsa041461.47663379
26Parkinsons disease_Homo sapiens_hsa050121.41751269
27Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.38413133
28Tryptophan metabolism_Homo sapiens_hsa003801.38223594
29Maturity onset diabetes of the young_Homo sapiens_hsa049501.29964872
30Taste transduction_Homo sapiens_hsa047421.28763833
31Insulin secretion_Homo sapiens_hsa049111.28626129
32Homologous recombination_Homo sapiens_hsa034401.27744365
33Regulation of autophagy_Homo sapiens_hsa041401.27360045
34RNA degradation_Homo sapiens_hsa030181.27216258
35Steroid biosynthesis_Homo sapiens_hsa001001.27200882
36GABAergic synapse_Homo sapiens_hsa047271.24581690
37Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.20705192
38beta-Alanine metabolism_Homo sapiens_hsa004101.20157764
39Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.18057254
40Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.14200298
41RNA polymerase_Homo sapiens_hsa030201.13400293
42Morphine addiction_Homo sapiens_hsa050321.08714078
43Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.08085954
44Primary bile acid biosynthesis_Homo sapiens_hsa001201.00253776
45Olfactory transduction_Homo sapiens_hsa047400.98962590
46Collecting duct acid secretion_Homo sapiens_hsa049660.98448898
47Circadian rhythm_Homo sapiens_hsa047100.95363731
48Dopaminergic synapse_Homo sapiens_hsa047280.94387995
49Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.92373907
50Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.91935500
51Glutamatergic synapse_Homo sapiens_hsa047240.90307562
52Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.88753801
53Cysteine and methionine metabolism_Homo sapiens_hsa002700.87510938
54Huntingtons disease_Homo sapiens_hsa050160.85383194
55Circadian entrainment_Homo sapiens_hsa047130.84058103
56Amphetamine addiction_Homo sapiens_hsa050310.83899144
57Hedgehog signaling pathway_Homo sapiens_hsa043400.82923294
58Steroid hormone biosynthesis_Homo sapiens_hsa001400.80189829
59Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.79267045
60Synaptic vesicle cycle_Homo sapiens_hsa047210.76940071
61Cardiac muscle contraction_Homo sapiens_hsa042600.76061316
62Retinol metabolism_Homo sapiens_hsa008300.75814069
63Chemical carcinogenesis_Homo sapiens_hsa052040.74899449
64Glycerolipid metabolism_Homo sapiens_hsa005610.74342129
65Ovarian steroidogenesis_Homo sapiens_hsa049130.74291154
66Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.73043218
67Fatty acid degradation_Homo sapiens_hsa000710.72114675
68Cyanoamino acid metabolism_Homo sapiens_hsa004600.71418594
69Serotonergic synapse_Homo sapiens_hsa047260.70882311
70Cocaine addiction_Homo sapiens_hsa050300.69897521
71Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.68992644
72Fatty acid metabolism_Homo sapiens_hsa012120.68789599
73ABC transporters_Homo sapiens_hsa020100.68070401
74Alzheimers disease_Homo sapiens_hsa050100.65417882
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.64462844
76Metabolic pathways_Homo sapiens_hsa011000.64180883
77Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.60490705
78Proteasome_Homo sapiens_hsa030500.60179076
79Sulfur metabolism_Homo sapiens_hsa009200.60146564
80Calcium signaling pathway_Homo sapiens_hsa040200.58293070
81Salivary secretion_Homo sapiens_hsa049700.56976188
82Fatty acid elongation_Homo sapiens_hsa000620.56692520
83Mineral absorption_Homo sapiens_hsa049780.54359461
84cAMP signaling pathway_Homo sapiens_hsa040240.53519594
85Basal cell carcinoma_Homo sapiens_hsa052170.53444401
86Arachidonic acid metabolism_Homo sapiens_hsa005900.52858222
87Dorso-ventral axis formation_Homo sapiens_hsa043200.50030208
88Pyruvate metabolism_Homo sapiens_hsa006200.49122722
89RNA transport_Homo sapiens_hsa030130.47789925
90Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.47475444
91Purine metabolism_Homo sapiens_hsa002300.46246127
92Sphingolipid metabolism_Homo sapiens_hsa006000.44685400
93Axon guidance_Homo sapiens_hsa043600.43857440
942-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.43652287
95Arginine and proline metabolism_Homo sapiens_hsa003300.43264118
96Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.41775094
97Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41583845
98Fat digestion and absorption_Homo sapiens_hsa049750.39223746
99Glucagon signaling pathway_Homo sapiens_hsa049220.39107951
100SNARE interactions in vesicular transport_Homo sapiens_hsa041300.38029696

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