ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	positive regulation of mast cell activation (GO:0033005)	9.56033261
2	regulation of tolerance induction (GO:0002643)	9.36830631
3	regulation of T cell cytokine production (GO:0002724)	9.04732823
4	cellular biogenic amine biosynthetic process (GO:0042401)	8.38607166
5	positive regulation of myeloid leukocyte mediated immunity (GO:0002888)	8.03485537
6	amine biosynthetic process (GO:0009309)	7.93346405
7	positive regulation of leukocyte degranulation (GO:0043302)	7.70375921
8	catechol-containing compound biosynthetic process (GO:0009713)	7.47935977
9	catecholamine biosynthetic process (GO:0042423)	7.47935977
10	regulation of mast cell activation involved in immune response (GO:0033006)	7.32554198
11	T cell apoptotic process (GO:0070231)	7.01745949
12	angiotensin maturation (GO:0002003)	6.49421713
13	regulation of mast cell activation (GO:0033003)	6.06956145
14	lymphocyte apoptotic process (GO:0070227)	5.98276068
15	regulation of mast cell degranulation (GO:0043304)	5.94238629
16	sequestering of actin monomers (GO:0042989)	5.72658849
17	lipoxygenase pathway (GO:0019372)	5.69627283
18	positive regulation of regulated secretory pathway (GO:1903307)	5.47953558
19	replication fork processing (GO:0031297)	5.29315416
20	leukocyte apoptotic process (GO:0071887)	5.06195484
21	endosome to pigment granule transport (GO:0043485)	4.96181449
22	endosome to melanosome transport (GO:0035646)	4.96181449
23	regulation of activated T cell proliferation (GO:0046006)	4.72134734
24	peroxisome fission (GO:0016559)	4.62334643
25	negative regulation of mast cell activation (GO:0033004)	4.47778777
26	thrombin receptor signaling pathway (GO:0070493)	4.43846714
27	DNA replication-dependent nucleosome organization (GO:0034723)	4.41031819
28	DNA replication-dependent nucleosome assembly (GO:0006335)	4.41031819
29	centriole replication (GO:0007099)	4.31454379
30	regulation of myeloid leukocyte mediated immunity (GO:0002886)	4.23559773
31	phenol-containing compound biosynthetic process (GO:0046189)	4.18111453
32	positive regulation of type I interferon-mediated signaling pathway (GO:0060340)	4.10983495
33	interleukin-6-mediated signaling pathway (GO:0070102)	4.08406337
34	regulation of leukocyte degranulation (GO:0043300)	4.07667157
35	negative regulation of norepinephrine secretion (GO:0010700)	4.07235711
36	regulation of glucokinase activity (GO:0033131)	4.07125063
37	regulation of hexokinase activity (GO:1903299)	4.07125063
38	centrosome duplication (GO:0051298)	4.03397517
39	protein neddylation (GO:0045116)	3.94003961
40	negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)	3.86667613
41	negative regulation of T-helper cell differentiation (GO:0045623)	3.86667613
42	adenosine receptor signaling pathway (GO:0001973)	3.75959395
43	tachykinin receptor signaling pathway (GO:0007217)	3.74376681
44	tyrosine phosphorylation of STAT protein (GO:0007260)	3.70529449
45	urate metabolic process (GO:0046415)	3.66973089
46	activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)	3.65142087
47	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	3.64061284
48	regulation of double-strand break repair via homologous recombination (GO:0010569)	3.61860107
49	regulation of MHC class II biosynthetic process (GO:0045346)	3.59128405
50	positive regulation of inositol phosphate biosynthetic process (GO:0060732)	3.45404595
51	regulation of isotype switching to IgG isotypes (GO:0048302)	3.45109175
52	purinergic nucleotide receptor signaling pathway (GO:0035590)	3.40429213
53	regulation of T cell mediated immunity (GO:0002709)	3.35758946
54	regulation of regulated secretory pathway (GO:1903305)	3.34912267
55	translesion synthesis (GO:0019985)	3.33325852
56	regulation of acyl-CoA biosynthetic process (GO:0050812)	3.31358354
57	resolution of meiotic recombination intermediates (GO:0000712)	3.31212830
58	cytokine biosynthetic process (GO:0042089)	3.27446440
59	mRNA transcription from RNA polymerase II promoter (GO:0042789)	3.24887798
60	leukotriene biosynthetic process (GO:0019370)	3.23896017
61	positive regulation of DNA recombination (GO:0045911)	3.22144295
62	centriole assembly (GO:0098534)	3.18375822
63	G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)	3.17599677
64	regulation of inositol phosphate biosynthetic process (GO:0010919)	3.16667787
65	regulation of meiosis I (GO:0060631)	3.14732483
66	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	3.14684324
67	negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)	3.14432070
68	positive regulation of natural killer cell differentiation (GO:0032825)	3.08776080
69	regulation of chronic inflammatory response (GO:0002676)	3.08561593
70	cellular response to virus (GO:0098586)	3.06678279
71	positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)	3.02776245
72	cytokine secretion (GO:0050663)	3.00699586
73	negative regulation of catecholamine secretion (GO:0033604)	2.95672812
74	positive regulation of gastrulation (GO:2000543)	2.93544316
75	positive regulation of endothelial cell differentiation (GO:0045603)	2.93075443
76	regulation of penile erection (GO:0060405)	2.92948055
77	catecholamine metabolic process (GO:0006584)	2.89260266
78	catechol-containing compound metabolic process (GO:0009712)	2.89260266
79	peptide hormone processing (GO:0016486)	2.85197618
80	regulation of cofactor metabolic process (GO:0051193)	2.84442245
81	regulation of coenzyme metabolic process (GO:0051196)	2.84442245
82	neutrophil activation (GO:0042119)	2.84003209
83	negative regulation of bone mineralization (GO:0030502)	2.81155015
84	negative regulation of alpha-beta T cell differentiation (GO:0046639)	2.78046760
85	neutrophil activation involved in immune response (GO:0002283)	2.68842782
86	phosphatidic acid biosynthetic process (GO:0006654)	2.68666888
87	phosphatidic acid metabolic process (GO:0046473)	2.68666888
88	metallo-sulfur cluster assembly (GO:0031163)	2.65708843
89	iron-sulfur cluster assembly (GO:0016226)	2.65708843
90	cytokine metabolic process (GO:0042107)	2.64536238
91	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	2.62353227
92	mRNA transcription (GO:0009299)	2.61965862
93	purinergic receptor signaling pathway (GO:0035587)	2.56915639
94	male meiosis (GO:0007140)	2.54434748
95	intra-S DNA damage checkpoint (GO:0031573)	2.51796405
96	protein kinase C-activating G-protein coupled receptor signaling pathway (GO:0007205)	2.49579126
97	imidazole-containing compound metabolic process (GO:0052803)	15.3797599
98	regulation of T cell tolerance induction (GO:0002664)	11.2692272
99	positive regulation of mast cell degranulation (GO:0043306)	10.8685761
100	positive regulation of mast cell activation involved in immune response (GO:0033008)	10.8685761

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	5.61899959
2	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.76766146
3	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	3.57341766
4	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	2.70780326
5	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	2.56530587
6	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.54759120
7	MYB_21317192_ChIP-Seq_ERMYB_Mouse	2.28350115
8	IRF1_19129219_ChIP-ChIP_H3396_Human	2.26569206
9	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	2.23064757
10	STAT6_21828071_ChIP-Seq_BEAS2B_Human	2.09659780
11	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	2.08895612
12	SRY_22984422_ChIP-ChIP_TESTIS_Rat	2.08305057
13	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.05693793
14	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	13.3965718
15	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.99527670
16	SCL_19346495_ChIP-Seq_HPC-7_Human	1.96510924
17	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.95644717
18	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	1.93507969
19	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	1.66036276
20	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.64717402
21	GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.64438484
22	EZH2_22144423_ChIP-Seq_EOC_Human	1.62791805
23	GATA1_19941826_ChIP-Seq_K562_Human	1.54676548
24	GBX2_23144817_ChIP-Seq_PC3_Human	1.48869327
25	VDR_22108803_ChIP-Seq_LS180_Human	1.42653882
26	WT1_19549856_ChIP-ChIP_CCG9911_Human	1.35669466
27	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.35344931
28	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.31745184
29	RUNX_20019798_ChIP-Seq_JUKART_Human	1.30661073
30	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.30507565
31	TP53_22573176_ChIP-Seq_HFKS_Human	1.30415700
32	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.24054997
33	DROSHA_22980978_ChIP-Seq_HELA_Human	1.23264113
34	GATA1_19941827_ChIP-Seq_MEL_Mouse	1.23186677
35	GATA1_22383799_ChIP-Seq_G1ME_Mouse	1.21205476
36	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	1.19711277
37	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.17429107
38	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.16895253
39	GATA2_19941826_ChIP-Seq_K562_Human	1.15879979
40	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.15302453
41	ELK4_26923725_Chip-Seq_MESODERM_Mouse	1.14030003
42	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.13460411
43	TAF2_19829295_ChIP-Seq_ESCs_Human	1.09832873
44	GATA2_22383799_ChIP-Seq_G1ME_Mouse	1.06667197
45	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.03532570
46	ER_23166858_ChIP-Seq_MCF-7_Human	1.01775831
47	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	0.99966443
48	OCT4_20526341_ChIP-Seq_ESCs_Human	0.99959567
49	SMAD1_18555785_Chip-Seq_ESCs_Mouse	0.98751635
50	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.97623288
51	GATA2_21666600_ChIP-Seq_HMVEC_Human	0.96991533
52	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.96911727
53	BCAT_22108803_ChIP-Seq_LS180_Human	0.95620378
54	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	0.94846780
55	NANOG_20526341_ChIP-Seq_ESCs_Human	0.92528857
56	IRF8_21731497_ChIP-ChIP_J774_Mouse	0.92165220
57	CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	0.92004063
58	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.91450472
59	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.91055054
60	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	0.90398150
61	KLF4_18555785_Chip-Seq_ESCs_Mouse	0.89327251
62	NANOG_19829295_ChIP-Seq_ESCs_Human	0.89065293
63	SOX2_19829295_ChIP-Seq_ESCs_Human	0.89065293
64	ZFX_18555785_Chip-Seq_ESCs_Mouse	0.88185878
65	RUNX1_22412390_ChIP-Seq_EML_Mouse	0.88030221
66	NMYC_18555785_Chip-Seq_ESCs_Mouse	0.86423819
67	SPI1_23127762_ChIP-Seq_K562_Human	0.86239574
68	SPI1_23547873_ChIP-Seq_NB4_Human	0.84927157
69	CTCF_18555785_Chip-Seq_ESCs_Mouse	0.84824780
70	SMRT_27268052_Chip-Seq_Bcells_Human	0.84289152
71	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.84211681
72	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	0.83459768
73	E2F7_22180533_ChIP-Seq_HELA_Human	0.82988684
74	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.82431049
75	PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	0.81822702
76	IRF8_27001747_Chip-Seq_BMDM_Mouse	0.80496198
77	TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human	0.79665186
78	OCT1_27270436_Chip-Seq_PROSTATE_Human	0.78480149
79	SOX2_18555785_Chip-Seq_ESCs_Mouse	0.78274892
80	P53_22387025_ChIP-Seq_ESCs_Mouse	0.77956031
81	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.76661908
82	OCT4_18555785_Chip-Seq_ESCs_Mouse	0.76372991
83	STAT3_23295773_ChIP-Seq_U87_Human	0.74647902
84	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	0.74525477
85	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	0.73035115
86	MYB_26560356_Chip-Seq_TH2_Human	0.72722925
87	P300_19829295_ChIP-Seq_ESCs_Human	0.71912558
88	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.71163964
89	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.71163964
90	HTT_18923047_ChIP-ChIP_STHdh_Human	0.70852657
91	ETS1_22383799_ChIP-Seq_G1ME_Mouse	0.69558239
92	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	0.68861436
93	NCOR_22424771_ChIP-Seq_293T_Human	0.68851973
94	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.68046553
95	IGF1R_20145208_ChIP-Seq_DFB_Human	0.67751930
96	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.67315020
97	GATA1_19941827_ChIP-Seq_MEL86_Mouse	0.67205088
98	TCF4_23295773_ChIP-Seq_U87_Human	0.66905355
99	SPI1_20517297_ChIP-Seq_HL60_Human	0.66844742
100	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	0.66570869

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002735_abnormal_chemical_nociception	7.98708024
2	MP0005464_abnormal_platelet_physiology	4.90243986
3	MP0005171_absent_coat_pigmentation	3.76046248
4	MP0002733_abnormal_thermal_nociception	3.13997707
5	MP0002734_abnormal_mechanical_nocicepti	2.97905527
6	MP0008961_abnormal_basal_metabolism	2.95710910
7	MP0001873_stomach_inflammation	2.87444824
8	MP0003183_abnormal_peptide_metabolism	2.85456965
9	MP0002971_abnormal_brown_adipose	2.69540180
10	MP0000372_irregular_coat_pigmentation	2.58663057
11	MP0002148_abnormal_hypersensitivity_rea	2.56946721
12	MP0009115_abnormal_fat_cell	2.44644480
13	MP0002736_abnormal_nociception_after	2.39075762
14	MP0005448_abnormal_energy_balance	2.35802085
15	MP0003638_abnormal_response/metabolism_	2.35607271
16	MP0005075_abnormal_melanosome_morpholog	2.33989040
17	MP0000465_gastrointestinal_hemorrhage	2.33654743
18	MP0008872_abnormal_physiological_respon	2.23138529
19	MP0005503_abnormal_tendon_morphology	2.14337236
20	MP0005083_abnormal_biliary_tract	2.11512929
21	MP0001970_abnormal_pain_threshold	2.05387286
22	MP0008058_abnormal_DNA_repair	1.98071071
23	MP0008004_abnormal_stomach_pH	1.93330875
24	MP0003283_abnormal_digestive_organ	1.89388813
25	MP0003787_abnormal_imprinting	1.81103542
26	MP0006276_abnormal_autonomic_nervous	1.79697249
27	MP0009765_abnormal_xenobiotic_induced	1.79147491
28	MP0001348_abnormal_lacrimal_gland	1.72485714
29	MP0001529_abnormal_vocalization	1.56834409
30	MP0003136_yellow_coat_color	1.53879710
31	MP0001968_abnormal_touch/_nociception	1.51960339
32	MP0009697_abnormal_copulation	1.47300324
33	MP0002970_abnormal_white_adipose	1.44893778
34	MP0005058_abnormal_lysosome_morphology	1.41230113
35	MP0005334_abnormal_fat_pad	1.39708078
36	MP0009840_abnormal_foam_cell	1.37007960
37	MP0005410_abnormal_fertilization	1.27702593
38	MP0005646_abnormal_pituitary_gland	1.26160179
39	MP0008877_abnormal_DNA_methylation	1.25406805
40	MP0000230_abnormal_systemic_arterial	1.23057016
41	MP0002572_abnormal_emotion/affect_behav	1.21986677
42	MP0005394_taste/olfaction_phenotype	1.19200815
43	MP0005499_abnormal_olfactory_system	1.19200815
44	MP0001835_abnormal_antigen_presentation	1.13108783
45	MP0001790_abnormal_immune_system	1.11618096
46	MP0005387_immune_system_phenotype	1.11618096
47	MP0005174_abnormal_tail_pigmentation	1.09621135
48	MP0003718_maternal_effect	1.09472064
49	MP0003950_abnormal_plasma_membrane	1.08216257
50	MP0001984_abnormal_olfaction	1.06935938
51	MP0006082_CNS_inflammation	1.05405432
52	MP0008995_early_reproductive_senescence	0.99412465
53	MP0001663_abnormal_digestive_system	0.98156686
54	MP0010329_abnormal_lipoprotein_level	0.96894160
55	MP0000733_abnormal_muscle_development	0.96682707
56	MP0009763_increased_sensitivity_to	0.96464166
57	MP0004130_abnormal_muscle_cell	0.93128607
58	MP0002398_abnormal_bone_marrow	0.92767249
59	MP0005647_abnormal_sex_gland	0.91445864
60	MP0002405_respiratory_system_inflammati	0.90344965
61	MP0002429_abnormal_blood_cell	0.86540623
62	MP0003698_abnormal_male_reproductive	0.85814987
63	MP0003724_increased_susceptibility_to	0.84735246
64	MP0010094_abnormal_chromosome_stability	0.84568258
65	MP0003195_calcinosis	0.83437962
66	MP0002722_abnormal_immune_system	0.82449924
67	MP0005167_abnormal_blood-brain_barrier	0.81576061
68	MP0000716_abnormal_immune_system	0.80084779
69	MP0002127_abnormal_cardiovascular_syste	0.79413014
70	MP0001800_abnormal_humoral_immune	0.79307723
71	MP0009642_abnormal_blood_homeostasis	0.78638485
72	MP0005076_abnormal_cell_differentiation	0.74114792
73	MP0008789_abnormal_olfactory_epithelium	0.73480306
74	MP0002234_abnormal_pharynx_morphology	0.71545665
75	MP0005332_abnormal_amino_acid	0.69812003
76	MP0002118_abnormal_lipid_homeostasis	0.68840141
77	MP0006036_abnormal_mitochondrial_physio	0.67769786
78	MP0000703_abnormal_thymus_morphology	0.67013119
79	MP0003953_abnormal_hormone_level	0.66840571
80	MP0005666_abnormal_adipose_tissue	0.65921915
81	MP0002272_abnormal_nervous_system	0.65272066
82	MP0001819_abnormal_immune_cell	0.65178180
83	MP0005584_abnormal_enzyme/coenzyme_acti	0.64730410
84	MP0002420_abnormal_adaptive_immunity	0.64243493
85	MP0002877_abnormal_melanocyte_morpholog	0.63677270
86	MP0002723_abnormal_immune_serum	0.62476853
87	MP0002078_abnormal_glucose_homeostasis	0.61035237
88	MP0003303_peritoneal_inflammation	0.60686871
89	MP0002822_catalepsy	0.60571297
90	MP0000249_abnormal_blood_vessel	0.60194340
91	MP0002210_abnormal_sex_determination	0.59848336
92	MP0005452_abnormal_adipose_tissue	0.59119655
93	MP0002452_abnormal_antigen_presenting	0.58918628
94	MP0000343_altered_response_to	0.56531689
95	MP0005310_abnormal_salivary_gland	0.56481932
96	MP0004185_abnormal_adipocyte_glucose	0.56247650
97	MP0001929_abnormal_gametogenesis	0.55081816
98	MP0000689_abnormal_spleen_morphology	0.54851744
99	MP0002102_abnormal_ear_morphology	0.54656972
100	MP0005671_abnormal_response_to	0.52491888

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Male infertility (HP:0003251)	8.99697141
2	Failure to thrive in infancy (HP:0001531)	7.52952986
3	Prolonged bleeding time (HP:0003010)	6.04713146
4	Petechiae (HP:0000967)	4.99979488
5	Menorrhagia (HP:0000132)	4.98145746
6	Increased mean platelet volume (HP:0011877)	4.75773682
7	Abnormal platelet volume (HP:0011876)	4.35411403
8	Hyperlipoproteinemia (HP:0010980)	4.14657775
9	Purpura (HP:0000979)	4.07210688
10	Rough bone trabeculation (HP:0100670)	3.94480879
11	Epistaxis (HP:0000421)	3.90242481
12	Premature graying of hair (HP:0002216)	3.83779564
13	Autoimmune thrombocytopenia (HP:0001973)	3.80498488
14	Rhinitis (HP:0012384)	3.65707823
15	Recurrent corneal erosions (HP:0000495)	3.65522317
16	Orthostatic hypotension (HP:0001278)	3.64918111
17	Renal Fanconi syndrome (HP:0001994)	3.57612148
18	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	3.56434179
19	Recurrent sinusitis (HP:0011108)	3.45356152
20	Gingival bleeding (HP:0000225)	3.44051030
21	Episodic fever (HP:0001954)	3.31308348
22	Abnormal delayed hypersensitivity skin test (HP:0002963)	3.30599745
23	Papilledema (HP:0001085)	3.30585866
24	Hypophosphatemic rickets (HP:0004912)	3.26306295
25	Generalized aminoaciduria (HP:0002909)	3.15954493
26	Impaired proprioception (HP:0010831)	2.97816270
27	Infertility (HP:0000789)	2.93808561
28	Abnormality of T cell physiology (HP:0011840)	2.92365978
29	Arthropathy (HP:0003040)	2.90174326
30	Alveolar cell carcinoma (HP:0006519)	2.87243801
31	Autoimmune hemolytic anemia (HP:0001890)	2.83933406
32	Impaired vibration sensation in the lower limbs (HP:0002166)	2.75491968
33	Impaired platelet aggregation (HP:0003540)	2.75422006
34	Abnormal platelet function (HP:0011869)	2.75422006
35	Abnormal trabecular bone morphology (HP:0100671)	2.73894374
36	Intrahepatic cholestasis (HP:0001406)	2.65643506
37	Ventricular fibrillation (HP:0001663)	2.61051828
38	Dysautonomia (HP:0002459)	2.50746885
39	Spontaneous hematomas (HP:0007420)	2.50002546
40	Neoplasm of the tracheobronchial system (HP:0100552)	2.48741475
41	Xanthomatosis (HP:0000991)	2.48666765
42	Abnormal drinking behavior (HP:0030082)	2.42437929
43	Polydipsia (HP:0001959)	2.42437929
44	Acute hepatic failure (HP:0006554)	2.37496393
45	Abnormality of the renal collecting system (HP:0004742)	2.36565117
46	Duplicated collecting system (HP:0000081)	2.31879373
47	Aplastic anemia (HP:0001915)	2.31678457
48	Cellular immunodeficiency (HP:0005374)	2.30197820
49	IgG deficiency (HP:0004315)	2.29836892
50	Chronic mucocutaneous candidiasis (HP:0002728)	2.29623929
51	Recurrent cutaneous fungal infections (HP:0011370)	2.29623929
52	Panhypogammaglobulinemia (HP:0003139)	2.29186379
53	Abnormality of transition element cation homeostasis (HP:0011030)	2.22059898
54	Bone marrow hypocellularity (HP:0005528)	2.20698240
55	Conjunctival telangiectasia (HP:0000524)	2.18833011
56	Bruising susceptibility (HP:0000978)	2.17912903
57	Alacrima (HP:0000522)	2.17078447
58	Stomatitis (HP:0010280)	2.14462291
59	Neurodegeneration (HP:0002180)	2.13530399
60	Cutaneous melanoma (HP:0012056)	2.12648357
61	Albinism (HP:0001022)	2.10137269
62	Tetraparesis (HP:0002273)	2.09297332
63	Abnormality of renal resorption (HP:0011038)	2.09128386
64	Spastic diplegia (HP:0001264)	2.06369622
65	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.03392808
66	Conjugated hyperbilirubinemia (HP:0002908)	2.00582068
67	Recurrent viral infections (HP:0004429)	1.99674697
68	Abnormality of pyrimidine metabolism (HP:0004353)	1.99156717
69	Abnormal autonomic nervous system physiology (HP:0012332)	1.95730831
70	Generalized hyperpigmentation (HP:0007440)	1.95071476
71	Abnormality of the vasculature of the conjunctiva (HP:0008054)	1.93780832
72	Dyschromatopsia (HP:0007641)	1.91566096
73	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	1.91027101
74	Poor eye contact (HP:0000817)	1.90995808
75	Basal ganglia calcification (HP:0002135)	1.90570790
76	Abolished electroretinogram (ERG) (HP:0000550)	1.88424953
77	Spastic gait (HP:0002064)	1.88314073
78	Congenital ichthyosiform erythroderma (HP:0007431)	1.87872722
79	Hyponatremia (HP:0002902)	1.87504643
80	Spontaneous abortion (HP:0005268)	1.86119303
81	Glycosuria (HP:0003076)	1.82707033
82	Abnormality of urine glucose concentration (HP:0011016)	1.82707033
83	Abnormality of the heme biosynthetic pathway (HP:0010472)	1.82469913
84	Decreased central vision (HP:0007663)	1.81744174
85	Abnormality of macrophages (HP:0004311)	1.79407829
86	Abnormality of T cells (HP:0002843)	1.77584678
87	Abnormality of the basal ganglia (HP:0002134)	1.76618367
88	Polyphagia (HP:0002591)	1.75647520
89	Aseptic necrosis (HP:0010885)	1.72962657
90	Poikilocytosis (HP:0004447)	1.72201650
91	Acanthocytosis (HP:0001927)	1.70718326
92	J-shaped sella turcica (HP:0002680)	1.64510928
93	Abnormality of sodium homeostasis (HP:0010931)	1.63497894
94	Decreased lacrimation (HP:0000633)	1.62265879
95	Congenital sensorineural hearing impairment (HP:0008527)	1.60179887
96	Abnormality of the hepatic vasculature (HP:0006707)	1.58864682
97	Bronchiectasis (HP:0002110)	1.58810492
98	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.58032926
99	Polyuria (HP:0000103)	1.57647565
100	Delusions (HP:0000746)	1.56017130

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TNIK	3.95579934
2	FER	2.63504454
3	TAOK1	2.53950752
4	GRK6	2.23769507
5	PNCK	2.10383453
6	TRIM28	11.9733076
7	MARK3	1.69557890
8	DAPK2	1.65818619
9	MATK	1.62030820
10	CSF1R	1.59280040
11	MST4	1.54979324
12	BCKDK	1.46243734
13	IRAK3	1.45632073
14	PDK2	1.39380065
15	BMX	1.32347545
16	PRKD2	1.31163295
17	PKN1	1.24797324
18	GRK5	1.22152293
19	MAPK13	1.19780576
20	FRK	1.19029711
21	MYLK	1.10720964
22	SIK3	1.03738867
23	BTK	0.99863977
24	TEC	0.95896367
25	FES	0.94714172
26	ADRBK2	0.94229068
27	SYK	0.93308770
28	BMPR2	0.92684546
29	TAOK2	0.89780989
30	PTK2B	0.85586562
31	SIK2	0.85116173
32	GRK7	0.84400505
33	GRK1	0.82013355
34	LYN	0.81263150
35	MARK2	0.81078728
36	PIK3CG	0.79384291
37	TNK2	0.78576885
38	ZAP70	0.76353054
39	CAMKK2	0.74786437
40	PAK1	0.69000497
41	RIPK4	0.67753897
42	IKBKE	0.65965579
43	CAMK1G	0.65673885
44	ADRBK1	0.65356100
45	NTRK3	0.65025692
46	DYRK1B	0.57987273
47	FGR	0.57277363
48	IRAK4	0.57141162
49	EPHA4	0.56815304
50	EIF2AK1	0.53924899
51	PRKCI	0.53865398
52	GSK3A	0.52824837
53	ERBB2	0.52728990
54	NTRK1	0.51104116
55	STK38	0.50772927
56	MAP4K1	0.49692487
57	WNK4	0.49550409
58	PIM1	0.49467013
59	ERBB3	0.48334004
60	HIPK2	0.47592869
61	CAMK2G	0.46487820
62	CAMK2B	0.45562271
63	DAPK1	0.45320528
64	IKBKB	0.45230164
65	CAMK2D	0.42735957
66	TESK2	0.42269862
67	PHKG1	0.41666022
68	PHKG2	0.41666022
69	STK3	0.41336948
70	INSR	0.40308375
71	MAPK10	0.39584085
72	PRKCE	0.38967154
73	STK16	0.36906327
74	MAPKAPK3	0.36794456
75	PDK1	0.36227780
76	PRKACG	0.35913274
77	STK39	0.34976004
78	DAPK3	0.34873107
79	TAOK3	0.34782166
80	HCK	0.34257403
81	PLK2	0.34114464
82	MARK1	0.33090428
83	PRKACA	0.32850703
84	CHUK	0.32783383
85	MAP2K7	0.32170141
86	PRPF4B	0.31984042
87	PRKCZ	0.31928015
88	ILK	0.31538138
89	BRSK2	0.31488830
90	CAMK2A	0.30953780
91	TGFBR2	0.30269914
92	OBSCN	0.29166824
93	CSK	0.28290039
94	PRKCA	0.27950615
95	BLK	0.27587568
96	WNK3	0.27268216
97	TLK1	0.26819577
98	JAK2	0.26794850
99	LCK	0.26540384
100	TBK1	0.25573361

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Histidine metabolism_Homo sapiens_hsa00340	6.96922268
2	Asthma_Homo sapiens_hsa05310	5.48789557
3	Renin-angiotensin system_Homo sapiens_hsa04614	5.41093681
4	Platelet activation_Homo sapiens_hsa04611	2.58623144
5	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	2.41802024
6	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	2.37307526
7	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.24553651
8	Hematopoietic cell lineage_Homo sapiens_hsa04640	2.22815780
9	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	2.01320422
10	Other glycan degradation_Homo sapiens_hsa00511	1.96972019
11	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.83429551
12	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.76775148
13	Pancreatic secretion_Homo sapiens_hsa04972	1.73782497
14	Caffeine metabolism_Homo sapiens_hsa00232	1.72357675
15	Olfactory transduction_Homo sapiens_hsa04740	1.68153314
16	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.54364057
17	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.53823996
18	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.48841472
19	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.39231146
20	Sphingolipid signaling pathway_Homo sapiens_hsa04071	1.34292511
21	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.29333100
22	Fanconi anemia pathway_Homo sapiens_hsa03460	1.25263372
23	Nitrogen metabolism_Homo sapiens_hsa00910	1.23559075
24	Linoleic acid metabolism_Homo sapiens_hsa00591	1.18143192
25	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.13832149
26	Phospholipase D signaling pathway_Homo sapiens_hsa04072	1.01126927
27	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.99707728
28	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.98843241
29	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.97916959
30	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.95616825
31	Long-term depression_Homo sapiens_hsa04730	0.94579782
32	Chemical carcinogenesis_Homo sapiens_hsa05204	0.90854579
33	Homologous recombination_Homo sapiens_hsa03440	0.90236880
34	Phototransduction_Homo sapiens_hsa04744	0.89646800
35	Oocyte meiosis_Homo sapiens_hsa04114	0.89183312
36	ECM-receptor interaction_Homo sapiens_hsa04512	0.86309771
37	Peroxisome_Homo sapiens_hsa04146	0.81161067
38	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.81037580
39	Calcium signaling pathway_Homo sapiens_hsa04020	0.77078870
40	Morphine addiction_Homo sapiens_hsa05032	0.76960172
41	Mismatch repair_Homo sapiens_hsa03430	0.75791469
42	Protein digestion and absorption_Homo sapiens_hsa04974	0.75653524
43	Dopaminergic synapse_Homo sapiens_hsa04728	0.73652465
44	Circadian entrainment_Homo sapiens_hsa04713	0.72096070
45	Gap junction_Homo sapiens_hsa04540	0.71577450
46	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.70418421
47	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.69868958
48	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.69431741
49	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.68198351
50	Taste transduction_Homo sapiens_hsa04742	0.67299045
51	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.66567369
52	Galactose metabolism_Homo sapiens_hsa00052	0.65914544
53	Retinol metabolism_Homo sapiens_hsa00830	0.64888245
54	Butanoate metabolism_Homo sapiens_hsa00650	0.64744833
55	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.64468891
56	Nucleotide excision repair_Homo sapiens_hsa03420	0.63732080
57	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.63162493
58	Basal transcription factors_Homo sapiens_hsa03022	0.61371034
59	Glycerolipid metabolism_Homo sapiens_hsa00561	0.60146529
60	Fat digestion and absorption_Homo sapiens_hsa04975	0.59853684
61	Chemokine signaling pathway_Homo sapiens_hsa04062	0.58908517
62	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.58748940
63	Serotonergic synapse_Homo sapiens_hsa04726	0.57886550
64	Primary immunodeficiency_Homo sapiens_hsa05340	0.56835459
65	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.54728019
66	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.54481556
67	ABC transporters_Homo sapiens_hsa02010	0.53566848
68	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.52349050
69	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.52278606
70	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.51224701
71	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.48249948
72	Hepatitis C_Homo sapiens_hsa05160	0.45870301
73	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.42159720
74	Alcoholism_Homo sapiens_hsa05034	0.41283308
75	GABAergic synapse_Homo sapiens_hsa04727	0.39504513
76	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.38600143
77	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.37121074
78	Lysosome_Homo sapiens_hsa04142	0.35468296
79	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.33987542
80	Gastric acid secretion_Homo sapiens_hsa04971	0.32984984
81	Glutamatergic synapse_Homo sapiens_hsa04724	0.32068837
82	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.31869151
83	Ether lipid metabolism_Homo sapiens_hsa00565	0.31542404
84	Cocaine addiction_Homo sapiens_hsa05030	0.31496528
85	Insulin secretion_Homo sapiens_hsa04911	0.28793509
86	Cholinergic synapse_Homo sapiens_hsa04725	0.28753822
87	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.28273544
88	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.25860130
89	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.24621845
90	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.24219920
91	Salivary secretion_Homo sapiens_hsa04970	0.22713473
92	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.22517564
93	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.22380172
94	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.21406201
95	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.20763692
96	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.20628364
97	Choline metabolism in cancer_Homo sapiens_hsa05231	0.20282486
98	Arginine biosynthesis_Homo sapiens_hsa00220	0.19639783
99	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.18801033
100	Allograft rejection_Homo sapiens_hsa05330	0.18493869

VN1R110P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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