VN1R12P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nodal signaling pathway (GO:0038092)7.37318354
2multicellular organism reproduction (GO:0032504)6.41245722
3phagocytosis, recognition (GO:0006910)6.10543492
4cellular ketone body metabolic process (GO:0046950)5.99483778
5platelet dense granule organization (GO:0060155)5.98495448
6acrosome reaction (GO:0007340)5.86274104
7fusion of sperm to egg plasma membrane (GO:0007342)5.76810082
8signal peptide processing (GO:0006465)5.41807661
9ketone body metabolic process (GO:1902224)5.28947731
10peptidyl-cysteine modification (GO:0018198)5.18004025
11regulation of mesoderm development (GO:2000380)4.94795097
12plasma membrane fusion (GO:0045026)4.94289101
13regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022354.71514341
14neural tube formation (GO:0001841)4.24840129
15reproduction (GO:0000003)4.10120356
16I-kappaB phosphorylation (GO:0007252)4.09348365
17negative regulation of meiosis (GO:0045835)4.08577636
18ER overload response (GO:0006983)3.76333034
19lactate metabolic process (GO:0006089)3.72456935
20negative regulation of lipase activity (GO:0060192)3.69908869
21negative regulation of activin receptor signaling pathway (GO:0032926)3.67323148
22aldehyde catabolic process (GO:0046185)3.60406293
23activin receptor signaling pathway (GO:0032924)3.60298821
24cholesterol efflux (GO:0033344)3.59881242
25L-phenylalanine catabolic process (GO:0006559)3.56142780
26erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.56142780
27signal transduction involved in regulation of gene expression (GO:0023019)3.52650203
28positive regulation of glycoprotein metabolic process (GO:1903020)3.48529237
29triglyceride homeostasis (GO:0070328)3.47104137
30acylglycerol homeostasis (GO:0055090)3.47104137
31sphingomyelin metabolic process (GO:0006684)3.46227457
32protein targeting to Golgi (GO:0000042)3.45934296
33secretory granule organization (GO:0033363)3.41675089
34positive regulation of growth hormone secretion (GO:0060124)3.41196453
35meiotic chromosome segregation (GO:0045132)3.39587911
36establishment of protein localization to Golgi (GO:0072600)3.36813588
37epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.36483842
38regulation of protein glycosylation (GO:0060049)3.33752369
39melanosome localization (GO:0032400)3.33108779
40regulation of Golgi to plasma membrane protein transport (GO:0042996)3.29248372
41negative regulation of glycogen metabolic process (GO:0070874)3.28153249
42intra-Golgi vesicle-mediated transport (GO:0006891)3.25372209
43regulation of activin receptor signaling pathway (GO:0032925)3.22901368
44lung vasculature development (GO:0060426)3.22740160
45activation of adenylate cyclase activity (GO:0007190)3.22486408
46axoneme assembly (GO:0035082)3.20229056
47sequestering of extracellular ligand from receptor (GO:0035581)3.20181234
48protein neddylation (GO:0045116)3.18597057
49regulation of cilium movement (GO:0003352)3.15349517
50pigment granule localization (GO:0051875)3.14962534
51negative regulation of dendrite development (GO:2000171)3.08891481
52intraciliary transport (GO:0042073)3.08829724
53cell migration involved in gastrulation (GO:0042074)3.08703982
54phospholipid homeostasis (GO:0055091)3.05120331
55photoreceptor cell maintenance (GO:0045494)3.05028284
56negative regulation of glycogen biosynthetic process (GO:0045719)3.02926674
57L-ascorbic acid metabolic process (GO:0019852)3.01421041
58regulation of timing of cell differentiation (GO:0048505)3.01298887
59somatic diversification of immune receptors via somatic mutation (GO:0002566)2.96352615
60somatic hypermutation of immunoglobulin genes (GO:0016446)2.96352615
61melanosome transport (GO:0032402)2.96264860
62establishment of melanosome localization (GO:0032401)2.95849888
63dopamine transport (GO:0015872)2.94606082
64endosome to pigment granule transport (GO:0043485)2.93916757
65endosome to melanosome transport (GO:0035646)2.93916757
66nucleotide transmembrane transport (GO:1901679)2.93829965
67retina homeostasis (GO:0001895)2.91911574
68UDP-N-acetylglucosamine metabolic process (GO:0006047)2.91062271
69regulation of cholesterol esterification (GO:0010872)2.90364129
70regulation of development, heterochronic (GO:0040034)2.89062729
71cilium morphogenesis (GO:0060271)2.88720489
72retrograde transport, vesicle recycling within Golgi (GO:0000301)2.88602739
73epithelial cilium movement (GO:0003351)2.88265306
74fucose metabolic process (GO:0006004)2.88053034
75regulation of growth hormone secretion (GO:0060123)2.87444413
76positive regulation of adenylate cyclase activity (GO:0045762)2.86064865
77negative regulation of dendrite morphogenesis (GO:0050774)2.85527305
78regulation of type B pancreatic cell apoptotic process (GO:2000674)2.85474703
79anterograde synaptic vesicle transport (GO:0048490)2.85193567
80DNA replication checkpoint (GO:0000076)2.79566032
81establishment of pigment granule localization (GO:0051905)2.77745660
82pigment granule transport (GO:0051904)2.77318850
83mitochondrial DNA replication (GO:0006264)2.72780568
84high-density lipoprotein particle remodeling (GO:0034375)2.72131587
85sperm-egg recognition (GO:0035036)2.71788678
86maternal placenta development (GO:0001893)2.70305723
87sperm motility (GO:0030317)2.69327441
88CDP-diacylglycerol biosynthetic process (GO:0016024)2.68508633
89negative regulation of cell-matrix adhesion (GO:0001953)2.67598232
90preassembly of GPI anchor in ER membrane (GO:0016254)2.67570731
91inner ear receptor stereocilium organization (GO:0060122)2.65940196
92phospholipid efflux (GO:0033700)2.64835997
93lipid particle organization (GO:0034389)2.61855585
94L-phenylalanine metabolic process (GO:0006558)2.60996457
95erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.60996457
96water-soluble vitamin biosynthetic process (GO:0042364)2.60477221
97positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.60379443
98aromatic amino acid family catabolic process (GO:0009074)2.58831872
99negative regulation of acute inflammatory response (GO:0002674)2.58816662
100mitotic sister chromatid cohesion (GO:0007064)2.58310896

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.86133829
2VDR_22108803_ChIP-Seq_LS180_Human3.64052675
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.51212447
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.47658435
5FLI1_27457419_Chip-Seq_LIVER_Mouse2.95632418
6ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.78417346
7RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.78034832
8PCGF2_27294783_Chip-Seq_ESCs_Mouse2.59338374
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.51234201
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.42923785
11EGR1_23403033_ChIP-Seq_LIVER_Mouse2.42634878
12P300_19829295_ChIP-Seq_ESCs_Human2.32467183
13ZNF274_21170338_ChIP-Seq_K562_Hela2.24107477
14KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.06784856
15KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.06784856
16KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.06784856
17ELK1_19687146_ChIP-ChIP_HELA_Human1.86679024
18GABP_17652178_ChIP-ChIP_JURKAT_Human1.83923635
19AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.82126896
20TAF15_26573619_Chip-Seq_HEK293_Human1.81416015
21CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.71810090
22SOX2_19829295_ChIP-Seq_ESCs_Human1.69354163
23NANOG_19829295_ChIP-Seq_ESCs_Human1.69354163
24SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.67497137
25GATA2_21666600_ChIP-Seq_HMVEC_Human1.66828408
26ESR1_20079471_ChIP-ChIP_T-47D_Human1.59302610
27BCAT_22108803_ChIP-Seq_LS180_Human1.54123570
28MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.52682898
29SUZ12_27294783_Chip-Seq_NPCs_Mouse1.50339464
30CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.49190188
31HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.48690357
32EST1_17652178_ChIP-ChIP_JURKAT_Human1.47291148
33IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.44420721
34CBP_20019798_ChIP-Seq_JUKART_Human1.44420721
35SMAD3_21741376_ChIP-Seq_EPCs_Human1.43556005
36SMAD4_21741376_ChIP-Seq_EPCs_Human1.42868035
37EZH2_27294783_Chip-Seq_NPCs_Mouse1.42857222
38SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41934235
39ZNF217_24962896_ChIP-Seq_MCF-7_Human1.41176769
40PCGF2_27294783_Chip-Seq_NPCs_Mouse1.40145523
41ZFP57_27257070_Chip-Seq_ESCs_Mouse1.39155689
42MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.37306510
43UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.36955480
44GBX2_23144817_ChIP-Seq_PC3_Human1.33974164
45FUS_26573619_Chip-Seq_HEK293_Human1.33853639
46ELF1_17652178_ChIP-ChIP_JURKAT_Human1.30398449
47TCF4_23295773_ChIP-Seq_U87_Human1.29302644
48NANOG_18555785_Chip-Seq_ESCs_Mouse1.28240610
49KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.28223382
50PADI4_21655091_ChIP-ChIP_MCF-7_Human1.28174516
51SMAD3_21741376_ChIP-Seq_HESCs_Human1.28167244
52ER_23166858_ChIP-Seq_MCF-7_Human1.24307216
53STAT3_23295773_ChIP-Seq_U87_Human1.24071916
54AR_25329375_ChIP-Seq_VCAP_Human1.23672317
55RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.22657183
56CTBP2_25329375_ChIP-Seq_LNCAP_Human1.22423155
57IGF1R_20145208_ChIP-Seq_DFB_Human1.20546576
58NFE2_27457419_Chip-Seq_LIVER_Mouse1.18942214
59TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.17912416
60P53_22387025_ChIP-Seq_ESCs_Mouse1.15723801
61NR3C1_21868756_ChIP-Seq_MCF10A_Human1.15518577
62EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.15262919
63MYC_19829295_ChIP-Seq_ESCs_Human1.09955490
64HTT_18923047_ChIP-ChIP_STHdh_Human1.09227018
65TP53_22573176_ChIP-Seq_HFKS_Human1.08207397
66HIF1A_21447827_ChIP-Seq_MCF-7_Human1.08183486
67E2F1_18555785_Chip-Seq_ESCs_Mouse1.07473582
68PHF8_20622853_ChIP-Seq_HELA_Human1.07390880
69TCF4_22108803_ChIP-Seq_LS180_Human1.07374433
70FOXA1_27270436_Chip-Seq_PROSTATE_Human1.07159883
71FOXA1_25329375_ChIP-Seq_VCAP_Human1.07159883
72HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.06147970
73CRX_20693478_ChIP-Seq_RETINA_Mouse1.05602717
74CTBP1_25329375_ChIP-Seq_LNCAP_Human1.04822098
75TP53_16413492_ChIP-PET_HCT116_Human1.04596726
76SMAD4_21741376_ChIP-Seq_HESCs_Human1.04569231
77PIAS1_25552417_ChIP-Seq_VCAP_Human1.04037467
78CDX2_22108803_ChIP-Seq_LS180_Human1.02728421
79NOTCH1_21737748_ChIP-Seq_TLL_Human1.02379688
80FOXA1_21572438_ChIP-Seq_LNCaP_Human1.02358169
81SRF_21415370_ChIP-Seq_HL-1_Mouse1.01982848
82HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.00946652
83KLF5_20875108_ChIP-Seq_MESCs_Mouse1.00850086
84EWS_26573619_Chip-Seq_HEK293_Human1.00352663
85RUNX2_22187159_ChIP-Seq_PCA_Human1.00069332
86SUZ12_18555785_Chip-Seq_ESCs_Mouse0.99610176
87FOXM1_26456572_ChIP-Seq_MCF-7_Human0.99168157
88SALL1_21062744_ChIP-ChIP_HESCs_Human0.99121336
89SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.98894300
90SMAD4_21799915_ChIP-Seq_A2780_Human0.98253343
91AUTS2_25519132_ChIP-Seq_293T-REX_Human0.97970250
92TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.97772982
93CBP_21632823_ChIP-Seq_H3396_Human0.97653073
94WT1_19549856_ChIP-ChIP_CCG9911_Human0.96519545
95GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.96263010
96ETV1_20927104_ChIP-Seq_GIST48_Human0.96089384
97SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.95679010
98P53_22127205_ChIP-Seq_FIBROBLAST_Human0.94568845
99CMYC_18555785_Chip-Seq_ESCs_Mouse0.94170912
100GATA3_21878914_ChIP-Seq_MCF-7_Human0.93777203

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006054_spinal_hemorrhage7.25120884
2MP0003787_abnormal_imprinting3.68966779
3MP0008877_abnormal_DNA_methylation3.66413112
4MP0003195_calcinosis3.19404152
5MP0002822_catalepsy3.11396093
6MP0008004_abnormal_stomach_pH3.10760682
7MP0004510_myositis2.82905451
8MP0003283_abnormal_digestive_organ2.77852041
9MP0002837_dystrophic_cardiac_calcinosis2.73737590
10MP0002928_abnormal_bile_duct2.65349289
11MP0005410_abnormal_fertilization2.55596374
12MP0004133_heterotaxia2.35543368
13MP0000013_abnormal_adipose_tissue2.15016308
14MP0005367_renal/urinary_system_phenotyp2.14352495
15MP0000516_abnormal_urinary_system2.14352495
16MP0002163_abnormal_gland_morphology2.14068587
17MP0003890_abnormal_embryonic-extraembry2.11173608
18MP0009697_abnormal_copulation2.02697910
19MP0004147_increased_porphyrin_level1.98920895
20MP0001984_abnormal_olfaction1.96161541
21MP0003252_abnormal_bile_duct1.89416715
22MP0003950_abnormal_plasma_membrane1.75747903
23MP0004043_abnormal_pH_regulation1.69924097
24MP0004381_abnormal_hair_follicle1.69385271
25MP0005551_abnormal_eye_electrophysiolog1.50292370
26MP0001879_abnormal_lymphatic_vessel1.50179466
27MP0005365_abnormal_bile_salt1.43764273
28MP0005174_abnormal_tail_pigmentation1.38358153
29MP0003567_abnormal_fetal_cardiomyocyte1.35807163
30MP0009840_abnormal_foam_cell1.34285907
31MP0010329_abnormal_lipoprotein_level1.33087891
32MP0001440_abnormal_grooming_behavior1.31966919
33MP0002090_abnormal_vision1.30433199
34MP0008775_abnormal_heart_ventricle1.29806929
35MP0000003_abnormal_adipose_tissue1.29250365
36MP0002254_reproductive_system_inflammat1.29210477
37MP0002736_abnormal_nociception_after1.24051556
38MP0005375_adipose_tissue_phenotype1.23081435
39MP0005253_abnormal_eye_physiology1.20990157
40MP0002277_abnormal_respiratory_mucosa1.20535271
41MP0001986_abnormal_taste_sensitivity1.17379755
42MP0003221_abnormal_cardiomyocyte_apopto1.16992338
43MP0001968_abnormal_touch/_nociception1.16583161
44MP0003186_abnormal_redox_activity1.15092670
45MP0000767_abnormal_smooth_muscle1.14692534
46MP0006072_abnormal_retinal_apoptosis1.13456897
47MP0002138_abnormal_hepatobiliary_system1.05396549
48MP0010352_gastrointestinal_tract_polyps1.05255371
49MP0005220_abnormal_exocrine_pancreas1.03307694
50MP0003633_abnormal_nervous_system1.03071749
51MP0004215_abnormal_myocardial_fiber1.02063519
52MP0005075_abnormal_melanosome_morpholog1.01720408
53MP0004885_abnormal_endolymph0.95978425
54MP0001486_abnormal_startle_reflex0.94316865
55MP0004134_abnormal_chest_morphology0.93031370
56MP0004264_abnormal_extraembryonic_tissu0.92772861
57MP0000015_abnormal_ear_pigmentation0.92586256
58MP0003011_delayed_dark_adaptation0.90017898
59MP0008872_abnormal_physiological_respon0.88804681
60MP0000427_abnormal_hair_cycle0.87834577
61MP0004742_abnormal_vestibular_system0.87407599
62MP0005164_abnormal_response_to0.87046888
63MP0002572_abnormal_emotion/affect_behav0.86142287
64MP0006036_abnormal_mitochondrial_physio0.85720567
65MP0002132_abnormal_respiratory_system0.82494234
66MP0009745_abnormal_behavioral_response0.81802229
67MP0001944_abnormal_pancreas_morphology0.81467377
68MP0000538_abnormal_urinary_bladder0.80839128
69MP0005330_cardiomyopathy0.76718882
70MP0003656_abnormal_erythrocyte_physiolo0.75421427
71MP0005379_endocrine/exocrine_gland_phen0.74737067
72MP0006035_abnormal_mitochondrial_morpho0.73336030
73MP0005666_abnormal_adipose_tissue0.73300573
74MP0010030_abnormal_orbit_morphology0.72890050
75MP0000372_irregular_coat_pigmentation0.72281936
76MP0001764_abnormal_homeostasis0.69473573
77MP0004019_abnormal_vitamin_homeostasis0.68391994
78MP0003880_abnormal_central_pattern0.68380341
79MP0003119_abnormal_digestive_system0.68043212
80MP0003191_abnormal_cellular_cholesterol0.67925417
81MP0003698_abnormal_male_reproductive0.67616505
82MP0000609_abnormal_liver_physiology0.66734448
83MP0002557_abnormal_social/conspecific_i0.66195377
84MP0002078_abnormal_glucose_homeostasis0.66050950
85MP0001929_abnormal_gametogenesis0.64836903
86MP0003943_abnormal_hepatobiliary_system0.64300038
87MP0008875_abnormal_xenobiotic_pharmacok0.63651022
88MP0003123_paternal_imprinting0.63116666
89MP0002118_abnormal_lipid_homeostasis0.62835369
90MP0002184_abnormal_innervation0.62816355
91MP0003693_abnormal_embryo_hatching0.62256119
92MP0005187_abnormal_penis_morphology0.61839489
93MP0003121_genomic_imprinting0.61830766
94MP0005334_abnormal_fat_pad0.61619281
95MP0004085_abnormal_heartbeat0.59688453
96MP0009046_muscle_twitch0.55030231
97MP0002751_abnormal_autonomic_nervous0.54792236
98MP0003122_maternal_imprinting0.53134628
99MP0005332_abnormal_amino_acid0.53070928
100MP0003137_abnormal_impulse_conducting0.53005288

Predicted human phenotypes

RankGene SetZ-score
1Intestinal atresia (HP:0011100)7.62165928
2Nuclear cataract (HP:0100018)7.49207433
3Double outlet right ventricle (HP:0001719)4.94305568
4Congenital malformation of the right heart (HP:0011723)4.94305568
5Oligodactyly (hands) (HP:0001180)4.90212903
6Gastrointestinal atresia (HP:0002589)4.27196014
7Aqueductal stenosis (HP:0002410)4.22327922
8Decreased central vision (HP:0007663)3.78618479
9Hepatoblastoma (HP:0002884)3.66035163
10Abnormality of the parathyroid morphology (HP:0011766)3.57921641
11Labial hypoplasia (HP:0000066)3.50616750
12Renal cortical cysts (HP:0000803)3.33392070
13Abnormality of alanine metabolism (HP:0010916)3.27262012
14Hyperalaninemia (HP:0003348)3.27262012
15Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.27262012
16Esophageal atresia (HP:0002032)3.24407585
17Hypoplastic female external genitalia (HP:0012815)3.19979695
18Congenital stationary night blindness (HP:0007642)3.18335481
19Chin dimple (HP:0010751)3.11267335
20Large for gestational age (HP:0001520)3.08605709
21Type I transferrin isoform profile (HP:0003642)3.00673926
22Zonular cataract (HP:0010920)2.98954957
23Oligodactyly (HP:0012165)2.96820420
24Pancreatic islet-cell hyperplasia (HP:0004510)2.92791408
25Chronic sinusitis (HP:0011109)2.88073307
26Abnormality of the renal cortex (HP:0011035)2.75429993
27Bifid tongue (HP:0010297)2.69792117
28Postural tremor (HP:0002174)2.66737205
29Abdominal situs inversus (HP:0003363)2.65869540
30Abnormality of abdominal situs (HP:0011620)2.65869540
31Hemivertebrae (HP:0002937)2.64038222
32Metaphyseal dysplasia (HP:0100255)2.63776183
33Absent rod-and cone-mediated responses on ERG (HP:0007688)2.63678273
34Enlarged kidneys (HP:0000105)2.61787511
35Aplasia/Hypoplasia of the tibia (HP:0005772)2.58485970
36Abnormality of the labia (HP:0000058)2.53371890
37Abnormality of lateral ventricle (HP:0030047)2.51934623
38Neoplasm of the oral cavity (HP:0100649)2.49743801
39Median cleft lip (HP:0000161)2.47874712
40Delayed puberty (HP:0000823)2.45320151
41Growth hormone deficiency (HP:0000824)2.43134540
42Short tibia (HP:0005736)2.38770801
43Gaze-evoked nystagmus (HP:0000640)2.35397036
44Abnormality of macular pigmentation (HP:0008002)2.32314611
45Anterior segment dysgenesis (HP:0007700)2.32150127
46Cupped ear (HP:0000378)2.32022236
47Mixed hearing impairment (HP:0000410)2.31982217
48Abnormality of methionine metabolism (HP:0010901)2.30385181
49Ketoacidosis (HP:0001993)2.30196126
50Horseshoe kidney (HP:0000085)2.27125022
51Abnormal protein glycosylation (HP:0012346)2.23997325
52Abnormal glycosylation (HP:0012345)2.23997325
53Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.23997325
54Abnormal protein N-linked glycosylation (HP:0012347)2.23997325
55Rib fusion (HP:0000902)2.22342566
56Methylmalonic acidemia (HP:0002912)2.20425518
57Breast carcinoma (HP:0003002)2.20379183
58Rhinitis (HP:0012384)2.20213502
59Hyperglycinuria (HP:0003108)2.18394217
60Broad alveolar ridges (HP:0000187)2.18182466
61Abnormality of the pancreatic islet cells (HP:0006476)2.17095354
62Abnormality of endocrine pancreas physiology (HP:0012093)2.17095354
63Pancreatic fibrosis (HP:0100732)2.16954240
64Cone-rod dystrophy (HP:0000548)2.16635681
653-Methylglutaconic aciduria (HP:0003535)2.13548724
66Absent radius (HP:0003974)2.07005728
67Down-sloping shoulders (HP:0200021)2.06984265
68Ketosis (HP:0001946)2.04021397
69Anophthalmia (HP:0000528)2.03190245
70Volvulus (HP:0002580)2.01114629
71Renal hypoplasia (HP:0000089)2.00836527
72Abnormality of midbrain morphology (HP:0002418)2.00397422
73Molar tooth sign on MRI (HP:0002419)2.00397422
74Abnormality of the antihelix (HP:0009738)1.99223438
75Scrotal hypoplasia (HP:0000046)1.97418498
76Aplasia involving forearm bones (HP:0009822)1.96777201
77Absent forearm bone (HP:0003953)1.96777201
78Preaxial hand polydactyly (HP:0001177)1.92939052
79Neoplasm of head and neck (HP:0012288)1.91846131
80Esophageal neoplasm (HP:0100751)1.91846131
81Respiratory difficulties (HP:0002880)1.91126071
82Abnormality of aspartate family amino acid metabolism (HP:0010899)1.91083277
83Pancreatic cysts (HP:0001737)1.90973384
84Hypogonadotrophic hypogonadism (HP:0000044)1.88071600
85Anencephaly (HP:0002323)1.86262926
86Chorioretinal coloboma (HP:0000567)1.84680285
87Laryngomalacia (HP:0001601)1.81991976
88Abnormality of the heme biosynthetic pathway (HP:0010472)1.81517260
89Abnormality of aromatic amino acid family metabolism (HP:0004338)1.81072030
90Attenuation of retinal blood vessels (HP:0007843)1.78169896
91Methylmalonic aciduria (HP:0012120)1.76308821
92Conjunctival hamartoma (HP:0100780)1.74573847
93Deep palmar crease (HP:0006191)1.73373915
94Progressive macrocephaly (HP:0004481)1.65328348
95Abnormal rod and cone electroretinograms (HP:0008323)1.64159966
96Neoplasm of the adrenal gland (HP:0100631)1.64054134
97Macular degeneration (HP:0000608)1.63219224
98Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.62319529
99Progressive inability to walk (HP:0002505)1.61554460
100Anosmia (HP:0000458)1.61151102

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.22999600
2ACVR1B4.93225457
3ERBB43.76866503
4MAP3K133.14955518
5TNIK3.05451235
6TLK12.97061267
7PDK22.92053255
8BMPR1B2.62858842
9MAP3K72.28502101
10ZAK2.24510307
11PINK11.99469563
12FGFR21.97811458
13GRK11.96203879
14TESK11.87362427
15CASK1.70528707
16NTRK31.67859366
17PASK1.63815944
18NEK61.56759439
19DAPK21.50412285
20RPS6KA41.47696430
21STK38L1.43328964
22WNK41.41537336
23PRKAA21.33236349
24SGK21.30153890
25ADRBK21.29387258
26KIT1.26471283
27MAP3K141.25366762
28TRIM281.22431801
29FLT31.22360424
30MST41.14505127
31WNK31.12476649
32TGFBR11.06660111
33ADRBK11.05964130
34PIK3CG1.05860822
35SGK31.02011383
36TSSK60.99313439
37STK30.98324397
38PTK2B0.94194639
39TNK20.91821423
40EIF2AK30.90030200
41PRKCG0.89662820
42PRKCH0.80515950
43LIMK10.78881970
44SGK2230.78384842
45SGK4940.78384842
46NLK0.76826599
47WEE10.76451819
48PAK30.75180844
49PRKCI0.74425286
50MAP3K20.73564257
51BRSK20.73040202
52MAP2K10.70857567
53NUAK10.70497246
54TIE10.69707142
55PRKD30.67016747
56TGFBR20.66728210
57PRKCE0.62137684
58CAMKK20.61094473
59CDK80.56746586
60BRD40.56319813
61MAP3K120.56125159
62STK390.54001931
63MAPK130.50712186
64RPS6KA50.47427365
65PAK60.46387348
66MKNK20.46114641
67BUB10.45864084
68PRKCQ0.45704313
69PKN10.45430758
70SGK10.43998400
71KDR0.42910606
72FES0.41992027
73CAMK2A0.41132834
74PHKG20.40139793
75PHKG10.40139793
76PLK10.39978694
77NME10.39824568
78ROCK10.39699299
79VRK10.36239920
80DYRK30.36081181
81RPS6KA20.36008284
82TAOK30.35228041
83INSRR0.34579586
84JAK20.34538811
85FGR0.34499251
86PKN20.34464900
87PRKCZ0.34280619
88CDK190.32716364
89ATM0.32541946
90KSR20.29420083
91KSR10.28546794
92OBSCN0.28197782
93PLK20.27684531
94RPS6KB10.26557193
95GRK50.25507544
96CSNK2A10.25180243
97MAP4K20.24129941
98EGFR0.23548752
99GRK70.23527510
100ERBB30.21473363

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.98894210
2Protein export_Homo sapiens_hsa030604.14489988
3Butanoate metabolism_Homo sapiens_hsa006503.04744843
4Vitamin B6 metabolism_Homo sapiens_hsa007502.91699277
5Maturity onset diabetes of the young_Homo sapiens_hsa049502.64862325
6Propanoate metabolism_Homo sapiens_hsa006402.59897294
7Sulfur relay system_Homo sapiens_hsa041222.33603945
8Non-homologous end-joining_Homo sapiens_hsa034502.29702594
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.22716274
10Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.16817676
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.08066476
12Fat digestion and absorption_Homo sapiens_hsa049751.99159083
13Fatty acid metabolism_Homo sapiens_hsa012121.91318488
14Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.88684471
15Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.88089667
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.73678337
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.71047613
18PPAR signaling pathway_Homo sapiens_hsa033201.64559458
19Fatty acid degradation_Homo sapiens_hsa000711.60333710
20Ether lipid metabolism_Homo sapiens_hsa005651.53000152
21Caffeine metabolism_Homo sapiens_hsa002321.52586992
22Proteasome_Homo sapiens_hsa030501.51087294
23Selenocompound metabolism_Homo sapiens_hsa004501.50797190
24beta-Alanine metabolism_Homo sapiens_hsa004101.49609385
25Oxidative phosphorylation_Homo sapiens_hsa001901.45162456
26RNA polymerase_Homo sapiens_hsa030201.38971818
27Tryptophan metabolism_Homo sapiens_hsa003801.37574953
28alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.35670642
29Linoleic acid metabolism_Homo sapiens_hsa005911.29831019
30Parkinsons disease_Homo sapiens_hsa050121.25073377
31Complement and coagulation cascades_Homo sapiens_hsa046101.25044567
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.24922938
33Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.22925762
34ABC transporters_Homo sapiens_hsa020101.22737497
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.13743593
36Mismatch repair_Homo sapiens_hsa034301.13610170
37Nitrogen metabolism_Homo sapiens_hsa009101.11810211
38Vitamin digestion and absorption_Homo sapiens_hsa049771.00969830
39Basal transcription factors_Homo sapiens_hsa030220.99693904
40Phototransduction_Homo sapiens_hsa047440.96447521
41Peroxisome_Homo sapiens_hsa041460.95354036
42TGF-beta signaling pathway_Homo sapiens_hsa043500.94685860
43Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.93846013
44Pyruvate metabolism_Homo sapiens_hsa006200.91403678
45Glycerolipid metabolism_Homo sapiens_hsa005610.88827733
46Glycerophospholipid metabolism_Homo sapiens_hsa005640.88799505
47Alzheimers disease_Homo sapiens_hsa050100.88413812
48RNA degradation_Homo sapiens_hsa030180.85509474
49Taste transduction_Homo sapiens_hsa047420.82351494
50Huntingtons disease_Homo sapiens_hsa050160.82179396
51African trypanosomiasis_Homo sapiens_hsa051430.81871145
52Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.80682972
53Insulin secretion_Homo sapiens_hsa049110.77462286
54Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.74157672
55Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.71532809
56Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.71463119
572-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.71404145
58Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.69144068
59Fructose and mannose metabolism_Homo sapiens_hsa000510.62885562
60Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.62602549
61NOD-like receptor signaling pathway_Homo sapiens_hsa046210.58744747
62Calcium signaling pathway_Homo sapiens_hsa040200.58032551
63Fatty acid biosynthesis_Homo sapiens_hsa000610.56974492
64Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.54334507
65Olfactory transduction_Homo sapiens_hsa047400.54145772
66Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.54072816
67Carbon metabolism_Homo sapiens_hsa012000.53736766
68Arginine and proline metabolism_Homo sapiens_hsa003300.53269557
69Metabolic pathways_Homo sapiens_hsa011000.53227707
70Purine metabolism_Homo sapiens_hsa002300.53164030
71Insulin resistance_Homo sapiens_hsa049310.53127276
72Fatty acid elongation_Homo sapiens_hsa000620.52920498
73Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.52368582
74Legionellosis_Homo sapiens_hsa051340.48407999
75Tight junction_Homo sapiens_hsa045300.47375468
76Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.47178788
77Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.47178112
78Chemical carcinogenesis_Homo sapiens_hsa052040.45368440
79Renin secretion_Homo sapiens_hsa049240.44112817
80Circadian entrainment_Homo sapiens_hsa047130.43692073
81Type II diabetes mellitus_Homo sapiens_hsa049300.43152178
82RNA transport_Homo sapiens_hsa030130.42532677
83Cysteine and methionine metabolism_Homo sapiens_hsa002700.42214834
84Serotonergic synapse_Homo sapiens_hsa047260.41597255
85Glucagon signaling pathway_Homo sapiens_hsa049220.40710164
86Dopaminergic synapse_Homo sapiens_hsa047280.40239862
87Primary bile acid biosynthesis_Homo sapiens_hsa001200.36862142
88Long-term depression_Homo sapiens_hsa047300.35821203
89Lysine degradation_Homo sapiens_hsa003100.35267055
90Hedgehog signaling pathway_Homo sapiens_hsa043400.34810402
91HIF-1 signaling pathway_Homo sapiens_hsa040660.34557458
92Tyrosine metabolism_Homo sapiens_hsa003500.33191745
93Glutathione metabolism_Homo sapiens_hsa004800.30983904
94Circadian rhythm_Homo sapiens_hsa047100.30800822
95Retinol metabolism_Homo sapiens_hsa008300.29888153
96Morphine addiction_Homo sapiens_hsa050320.28717936
97Vibrio cholerae infection_Homo sapiens_hsa051100.28090807
98p53 signaling pathway_Homo sapiens_hsa041150.27166463
99Arachidonic acid metabolism_Homo sapiens_hsa005900.22207061
100Fanconi anemia pathway_Homo sapiens_hsa034600.21361111

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