VN1R2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm motility (GO:0030317)9.59745652
2fusion of sperm to egg plasma membrane (GO:0007342)9.00680662
3plasma membrane fusion (GO:0045026)8.05891323
4single strand break repair (GO:0000012)7.61967703
5sperm capacitation (GO:0048240)7.44877886
6spermatid nucleus differentiation (GO:0007289)7.22491697
7multicellular organism reproduction (GO:0032504)6.67770335
8spermatid development (GO:0007286)6.64440101
9sperm-egg recognition (GO:0035036)6.58730241
10microtubule depolymerization (GO:0007019)6.42434860
11chromosome condensation (GO:0030261)6.35752865
12DNA packaging (GO:0006323)6.28671832
13axonemal dynein complex assembly (GO:0070286)6.15302051
14reproduction (GO:0000003)5.99247294
15calcium ion-dependent exocytosis (GO:0017156)5.93076257
16protein polyglutamylation (GO:0018095)5.90922938
17cellular ketone body metabolic process (GO:0046950)5.55955751
18phosphatidylethanolamine biosynthetic process (GO:0006646)5.52931460
19binding of sperm to zona pellucida (GO:0007339)5.48557217
20rRNA methylation (GO:0031167)5.46294402
21cell-cell recognition (GO:0009988)5.37893694
22microtubule polymerization or depolymerization (GO:0031109)5.28715734
23phosphatidylethanolamine metabolic process (GO:0046337)5.14841815
24cilium or flagellum-dependent cell motility (GO:0001539)5.07223178
25spermatogenesis (GO:0007283)4.99553913
26regulation of cilium movement (GO:0003352)4.99245882
27male gamete generation (GO:0048232)4.97869245
28protein targeting to Golgi (GO:0000042)4.95885858
29ketone body metabolic process (GO:1902224)4.95697881
30establishment of protein localization to Golgi (GO:0072600)4.94848933
31negative regulation of inclusion body assembly (GO:0090084)4.76066318
32sexual reproduction (GO:0019953)4.71762415
33microtubule severing (GO:0051013)4.69117707
34rRNA modification (GO:0000154)4.59277422
35gamete generation (GO:0007276)4.58417637
36motile cilium assembly (GO:0044458)4.52087619
37retrograde transport, vesicle recycling within Golgi (GO:0000301)4.51547423
38positive regulation of Rab GTPase activity (GO:0032851)4.50739497
39regulation of Rab GTPase activity (GO:0032313)4.50739497
40RNA destabilization (GO:0050779)4.48621794
41single fertilization (GO:0007338)4.37025936
42epithelial cilium movement (GO:0003351)4.33909957
43centriole replication (GO:0007099)4.23103251
44regulation of transcription involved in cell fate commitment (GO:0060850)4.23029807
45coenzyme catabolic process (GO:0009109)4.18596274
46cell wall macromolecule catabolic process (GO:0016998)4.16925222
47seminiferous tubule development (GO:0072520)4.06516164
48cell wall macromolecule metabolic process (GO:0044036)3.97344893
49antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.96922639
50germ cell development (GO:0007281)3.86936903
51chromatin silencing (GO:0006342)3.82418759
52protein localization to Golgi apparatus (GO:0034067)3.81341021
53cilium movement (GO:0003341)3.72799336
54negative regulation of Rho protein signal transduction (GO:0035024)3.63283453
55multicellular organismal reproductive process (GO:0048609)3.61275228
56cellular process involved in reproduction in multicellular organism (GO:0022412)3.61102766
57fertilization (GO:0009566)3.54372168
58regulation of microtubule-based movement (GO:0060632)3.52029519
59epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.45360835
60peptidyl-threonine dephosphorylation (GO:0035970)3.43843508
61centriole assembly (GO:0098534)3.42630623
62cell differentiation involved in metanephros development (GO:0072202)3.35746060
63organic cation transport (GO:0015695)3.25018169
64regulation of inclusion body assembly (GO:0090083)3.23871635
65tachykinin receptor signaling pathway (GO:0007217)3.20333236
66regulation of somitogenesis (GO:0014807)3.19909188
67NAD biosynthetic process (GO:0009435)3.02048720
68piRNA metabolic process (GO:0034587)3.01902468
69axoneme assembly (GO:0035082)3.01861047
70multicellular organismal movement (GO:0050879)2.96094278
71musculoskeletal movement (GO:0050881)2.96094278
72cilium organization (GO:0044782)2.92902893
73negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.92383158
74regulation of centriole replication (GO:0046599)2.91860881
75cilium assembly (GO:0042384)2.91730017
76cell recognition (GO:0008037)2.88298756
77positive regulation of action potential (GO:0045760)2.87507955
78negative regulation of gene expression, epigenetic (GO:0045814)2.86373011
79C4-dicarboxylate transport (GO:0015740)2.85599662
80male meiosis I (GO:0007141)2.82494865
81mesenchymal cell differentiation involved in renal system development (GO:2001012)2.81367543
82mesenchymal cell differentiation involved in kidney development (GO:0072161)2.81367543
83spinal cord motor neuron differentiation (GO:0021522)2.80778690
84microtubule nucleation (GO:0007020)2.79560302
85DNA methylation involved in gamete generation (GO:0043046)2.79258625
86glycerol ether metabolic process (GO:0006662)2.79019794
87nucleus organization (GO:0006997)2.75357053
88histone mRNA catabolic process (GO:0071044)2.74479218
89somite rostral/caudal axis specification (GO:0032525)2.72848972
90nonmotile primary cilium assembly (GO:0035058)2.72726463
91response to acidic pH (GO:0010447)2.72655785
92cranial nerve morphogenesis (GO:0021602)2.65961542
93detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.62805907
94cellular response to pH (GO:0071467)2.59054065
95ether metabolic process (GO:0018904)2.58431871
96multicellular organismal development (GO:0007275)2.57479069
97cerebral cortex neuron differentiation (GO:0021895)2.53216299
98estrogen biosynthetic process (GO:0006703)2.50702299
99alanine transport (GO:0032328)2.49652391
100acrosome reaction (GO:0007340)10.7511409

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.07012873
2EZH2_22144423_ChIP-Seq_EOC_Human2.68854981
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.60551825
4CTBP2_25329375_ChIP-Seq_LNCAP_Human2.57528921
5CTBP1_25329375_ChIP-Seq_LNCAP_Human2.43325375
6CBP_20019798_ChIP-Seq_JUKART_Human2.26952133
7IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.26952133
8VDR_22108803_ChIP-Seq_LS180_Human2.22921363
9POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.21659437
10TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.21659437
11TAF15_26573619_Chip-Seq_HEK293_Human2.18339401
12TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.10145667
13FUS_26573619_Chip-Seq_HEK293_Human2.09794357
14ER_23166858_ChIP-Seq_MCF-7_Human2.08046435
15EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.92467931
16UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.91121481
17P300_19829295_ChIP-Seq_ESCs_Human1.87911696
18MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.77508994
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.76136326
20NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.76064641
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.75818159
22* EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.66896611
23AR_25329375_ChIP-Seq_VCAP_Human1.65669757
24* ERA_21632823_ChIP-Seq_H3396_Human1.65410908
25SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.63388902
26RAC3_21632823_ChIP-Seq_H3396_Human1.60110132
27AUTS2_25519132_ChIP-Seq_293T-REX_Human1.58278920
28NANOG_20526341_ChIP-Seq_ESCs_Human1.57428161
29GBX2_23144817_ChIP-Seq_PC3_Human1.57019106
30MYC_19829295_ChIP-Seq_ESCs_Human1.56265929
31GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.55562595
32ETV2_25802403_ChIP-Seq_MESCs_Mouse1.52912232
33TOP2B_26459242_ChIP-Seq_MCF-7_Human1.50212766
34POU3F2_20337985_ChIP-ChIP_501MEL_Human1.49502896
35KLF5_20875108_ChIP-Seq_MESCs_Mouse1.48727646
36SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.48184799
37SMAD3_21741376_ChIP-Seq_EPCs_Human1.47837300
38WDR5_24793694_ChIP-Seq_LNCAP_Human1.46596154
39RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.45402570
40DROSHA_22980978_ChIP-Seq_HELA_Human1.45222255
41EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.44557161
42SALL1_21062744_ChIP-ChIP_HESCs_Human1.42388553
43SMAD4_21799915_ChIP-Seq_A2780_Human1.42144126
44RUNX2_22187159_ChIP-Seq_PCA_Human1.41326175
45SMAD4_21741376_ChIP-Seq_EPCs_Human1.40771414
46GATA3_21878914_ChIP-Seq_MCF-7_Human1.40523969
47TAF2_19829295_ChIP-Seq_ESCs_Human1.39228394
48CBX2_27304074_Chip-Seq_ESCs_Mouse1.37355045
49VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.34263280
50IGF1R_20145208_ChIP-Seq_DFB_Human1.34136012
51SOX2_19829295_ChIP-Seq_ESCs_Human1.33823557
52NANOG_19829295_ChIP-Seq_ESCs_Human1.33823557
53STAT3_23295773_ChIP-Seq_U87_Human1.31600657
54REST_21632747_ChIP-Seq_MESCs_Mouse1.30137212
55ZFP57_27257070_Chip-Seq_ESCs_Mouse1.28303762
56BMI1_23680149_ChIP-Seq_NPCS_Mouse1.28111699
57OCT4_20526341_ChIP-Seq_ESCs_Human1.27720989
58PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.25101393
59EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.24361509
60ARNT_22903824_ChIP-Seq_MCF-7_Human1.23355305
61ELF1_20517297_ChIP-Seq_JURKAT_Human1.22503381
62TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.22392562
63NCOR_22424771_ChIP-Seq_293T_Human1.18887427
64SUZ12_27294783_Chip-Seq_ESCs_Mouse1.18596387
65* E2F1_20622854_ChIP-Seq_HELA_Human1.17885574
66FOXA1_25329375_ChIP-Seq_VCAP_Human1.16794657
67FOXA1_27270436_Chip-Seq_PROSTATE_Human1.16794657
68TP53_18474530_ChIP-ChIP_U2OS_Human1.15795349
69SMAD3_21741376_ChIP-Seq_ESCs_Human1.15682238
70BCL6_27268052_Chip-Seq_Bcells_Human1.15475862
71SMRT_27268052_Chip-Seq_Bcells_Human1.14386955
72ETV1_20927104_ChIP-Seq_GIST48_Human1.13510760
73P53_21459846_ChIP-Seq_SAOS-2_Human1.13477497
74TP63_19390658_ChIP-ChIP_HaCaT_Human1.13247574
75AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.12009379
76TDRD3_21172665_ChIP-Seq_MCF-7_Human1.11081078
77HOXB7_26014856_ChIP-Seq_BT474_Human1.10947285
78SMAD4_21741376_ChIP-Seq_HESCs_Human1.10738120
79CBX2_22325352_ChIP-Seq_293T-Rex_Human1.09619895
80TCF4_23295773_ChIP-Seq_U87_Human1.09577403
81RBPJ_21746931_ChIP-Seq_IB4_Human1.08897674
82FOXH1_21741376_ChIP-Seq_EPCs_Human1.08252501
83RNF2_27304074_Chip-Seq_NSC_Mouse1.07911710
84FOXA1_21572438_ChIP-Seq_LNCaP_Human1.07225767
85HNFA_21074721_ChIP-Seq_CACO-2_Human1.07122590
86PRDM14_20953172_ChIP-Seq_ESCs_Human1.06024705
87EZH2_27294783_Chip-Seq_ESCs_Mouse1.05935523
88NFYB_21822215_ChIP-Seq_K562_Human1.05493005
89ERG_20517297_ChIP-Seq_VCAP_Human1.04654010
90TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.03895294
91CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.02591756
92GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.01652737
93YY1_22570637_ChIP-Seq_MALME-3M_Human1.01056202
94TBL1_22424771_ChIP-Seq_293T_Human1.00622130
95CEBPB_22108803_ChIP-Seq_LS180_Human0.99735248
96OCT1_27270436_Chip-Seq_PROSTATE_Human0.98885200
97EZH2_27304074_Chip-Seq_ESCs_Mouse0.98752439
98P300_27268052_Chip-Seq_Bcells_Human0.98752241
99REST_18959480_ChIP-ChIP_MESCs_Mouse0.98593830
100PHF8_20622854_ChIP-Seq_HELA_Human0.98232529

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization8.88282107
2MP0003698_abnormal_male_reproductive3.43391074
3MP0005377_hearing/vestibular/ear_phenot3.23025612
4MP0003878_abnormal_ear_physiology3.23025612
5MP0005670_abnormal_white_adipose3.20699718
6MP0001929_abnormal_gametogenesis2.93163528
7MP0003646_muscle_fatigue2.90122040
8MP0001968_abnormal_touch/_nociception2.48476184
9MP0003011_delayed_dark_adaptation2.47585458
10MP0005379_endocrine/exocrine_gland_phen2.32244385
11MP0002822_catalepsy2.15001547
12MP0002735_abnormal_chemical_nociception2.14725614
13MP0001348_abnormal_lacrimal_gland2.12018291
14MP0002234_abnormal_pharynx_morphology2.04324183
15MP0003718_maternal_effect1.91723228
16MP0001486_abnormal_startle_reflex1.83046630
17MP0002161_abnormal_fertility/fecundity1.78471009
18MP0005551_abnormal_eye_electrophysiolog1.77263726
19MP0006292_abnormal_olfactory_placode1.68621209
20MP0005253_abnormal_eye_physiology1.65196869
21MP0002132_abnormal_respiratory_system1.63089112
22MP0001986_abnormal_taste_sensitivity1.59668875
23MP0002102_abnormal_ear_morphology1.57629677
24MP0005423_abnormal_somatic_nervous1.53222121
25MP0000678_abnormal_parathyroid_gland1.47719467
26MP0001984_abnormal_olfaction1.42732738
27MP0008877_abnormal_DNA_methylation1.38198942
28MP0002210_abnormal_sex_determination1.38162600
29MP0002733_abnormal_thermal_nociception1.35995436
30MP0009745_abnormal_behavioral_response1.35302919
31MP0002272_abnormal_nervous_system1.32153976
32MP0008995_early_reproductive_senescence1.29421153
33MP0000372_irregular_coat_pigmentation1.28017642
34MP0008789_abnormal_olfactory_epithelium1.26723743
35MP0002138_abnormal_hepatobiliary_system1.23358891
36MP0005084_abnormal_gallbladder_morpholo1.23232049
37MP0001485_abnormal_pinna_reflex1.18476856
38MP0000653_abnormal_sex_gland1.17251221
39MP0003880_abnormal_central_pattern1.17141619
40MP0002557_abnormal_social/conspecific_i1.16349796
41MP0001970_abnormal_pain_threshold1.15921324
42MP0004859_abnormal_synaptic_plasticity1.15240850
43MP0001145_abnormal_male_reproductive1.13178718
44MP0006276_abnormal_autonomic_nervous1.10748698
45MP0002734_abnormal_mechanical_nocicepti1.10491257
46MP0002229_neurodegeneration1.10414642
47MP0002736_abnormal_nociception_after1.09030150
48MP0004742_abnormal_vestibular_system1.07076249
49MP0002067_abnormal_sensory_capabilities1.06753377
50MP0005645_abnormal_hypothalamus_physiol1.06401792
51MP0009046_muscle_twitch1.06166774
52MP0003195_calcinosis1.05913202
53MP0001501_abnormal_sleep_pattern1.05424585
54MP0002127_abnormal_cardiovascular_syste1.05161921
55MP0005394_taste/olfaction_phenotype1.04651255
56MP0005499_abnormal_olfactory_system1.04651255
57MP0000049_abnormal_middle_ear1.03824371
58MP0002282_abnormal_trachea_morphology1.03785045
59MP0001963_abnormal_hearing_physiology1.01653582
60MP0002837_dystrophic_cardiac_calcinosis1.01397413
61MP0000516_abnormal_urinary_system1.00160852
62MP0005367_renal/urinary_system_phenotyp1.00160852
63MP0003635_abnormal_synaptic_transmissio0.97306048
64MP0002572_abnormal_emotion/affect_behav0.97299152
65MP0000026_abnormal_inner_ear0.96486975
66MP0000955_abnormal_spinal_cord0.96300802
67MP0001765_abnormal_ion_homeostasis0.93658839
68MP0002249_abnormal_larynx_morphology0.89612164
69MP0004484_altered_response_of0.89091927
70MP0002653_abnormal_ependyma_morphology0.88043414
71MP0001905_abnormal_dopamine_level0.87685543
72MP0001764_abnormal_homeostasis0.87255567
73MP0008775_abnormal_heart_ventricle0.86581098
74MP0006072_abnormal_retinal_apoptosis0.83875157
75MP0008872_abnormal_physiological_respon0.82988622
76MP0009697_abnormal_copulation0.80686919
77MP0005395_other_phenotype0.79045009
78MP0004085_abnormal_heartbeat0.78779015
79MP0005646_abnormal_pituitary_gland0.77914646
80MP0002638_abnormal_pupillary_reflex0.76160412
81MP0005167_abnormal_blood-brain_barrier0.75413513
82MP0003122_maternal_imprinting0.74543685
83MP0004043_abnormal_pH_regulation0.73919242
84MP0001666_abnormal_nutrient_absorption0.73368820
85MP0005636_abnormal_mineral_homeostasis0.72290374
86MP0005391_vision/eye_phenotype0.72077225
87MP0003121_genomic_imprinting0.72036126
88MP0002752_abnormal_somatic_nervous0.70541665
89MP0003136_yellow_coat_color0.70517945
90MP0004142_abnormal_muscle_tone0.69844259
91MP0009053_abnormal_anal_canal0.69842179
92MP0002063_abnormal_learning/memory/cond0.68721075
93MP0002928_abnormal_bile_duct0.68708852
94MP0002163_abnormal_gland_morphology0.68294828
95MP0000681_abnormal_thyroid_gland0.67871785
96MP0005310_abnormal_salivary_gland0.67473103
97MP0002064_seizures0.65893931
98MP0002882_abnormal_neuron_morphology0.65810855
99MP0002876_abnormal_thyroid_physiology0.65199340
100MP0000613_abnormal_salivary_gland0.64167037

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)5.98296666
2Attenuation of retinal blood vessels (HP:0007843)5.24934380
3Bony spicule pigmentary retinopathy (HP:0007737)4.79684571
4Dynein arm defect of respiratory motile cilia (HP:0012255)4.56536548
5Absent/shortened dynein arms (HP:0200106)4.56536548
6Abnormal respiratory epithelium morphology (HP:0012253)4.30517985
7Abnormal respiratory motile cilium morphology (HP:0005938)4.30517985
8Chronic hepatic failure (HP:0100626)4.20278984
9Abnormal rod and cone electroretinograms (HP:0008323)4.06789172
10Abnormality of macular pigmentation (HP:0008002)3.95790099
11Abnormal ciliary motility (HP:0012262)3.85151078
12Tubulointerstitial nephritis (HP:0001970)3.81674675
13Nephronophthisis (HP:0000090)3.64053964
14Abnormal respiratory motile cilium physiology (HP:0012261)3.51723419
15Abnormality of the renal medulla (HP:0100957)3.07233739
16Azoospermia (HP:0000027)3.03622606
17Facial shape deformation (HP:0011334)2.91754928
18Potter facies (HP:0002009)2.91754928
19Pancreatic cysts (HP:0001737)2.88370739
20Hypoplasia of the thymus (HP:0000778)2.87097005
21Congenital stationary night blindness (HP:0007642)2.85283484
22Progressive cerebellar ataxia (HP:0002073)2.84715010
23Retinal dysplasia (HP:0007973)2.78286350
24Pancreatic fibrosis (HP:0100732)2.78102668
25Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.75790997
26Abnormal spermatogenesis (HP:0008669)2.75552627
27Hyperkalemia (HP:0002153)2.72180773
28Decreased central vision (HP:0007663)2.66091732
29Medial flaring of the eyebrow (HP:0010747)2.65249464
30Hypoplastic ischia (HP:0003175)2.60453745
31Pendular nystagmus (HP:0012043)2.59476091
32Aplasia/Hypoplasia of the earlobes (HP:0009906)2.54524458
33Abnormality of midbrain morphology (HP:0002418)2.53523609
34Molar tooth sign on MRI (HP:0002419)2.53523609
35Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.50424563
36Unilateral renal agenesis (HP:0000122)2.50137647
37Double outlet right ventricle (HP:0001719)2.49956729
38Congenital malformation of the right heart (HP:0011723)2.49956729
39Infertility (HP:0000789)2.49566774
40Gait imbalance (HP:0002141)2.47841499
41Type II lissencephaly (HP:0007260)2.46448913
42Renal dysplasia (HP:0000110)2.46242050
43Abnormal urine output (HP:0012590)2.45441938
44Bell-shaped thorax (HP:0001591)2.42347170
45Asymmetric septal hypertrophy (HP:0001670)2.41411763
46Congenital primary aphakia (HP:0007707)2.40044177
47Nephrogenic diabetes insipidus (HP:0009806)2.38710630
48Resting tremor (HP:0002322)2.36531675
49Polydipsia (HP:0001959)2.36370674
50Abnormal drinking behavior (HP:0030082)2.36370674
51True hermaphroditism (HP:0010459)2.34360073
52Abnormality of the parathyroid morphology (HP:0011766)2.32442476
53Impulsivity (HP:0100710)2.30834779
54Abnormality of the renal cortex (HP:0011035)2.28236892
55Polyuria (HP:0000103)2.26566689
56Genital tract atresia (HP:0001827)2.25716095
57Stage 5 chronic kidney disease (HP:0003774)2.25675805
58Cerebellar dysplasia (HP:0007033)2.25256973
59Postaxial foot polydactyly (HP:0001830)2.21885849
60Congenital hepatic fibrosis (HP:0002612)2.21430536
61Abnormality of the aortic arch (HP:0012303)2.20604411
62Abnormality of the ischium (HP:0003174)2.20295249
63Vaginal atresia (HP:0000148)2.16508653
64Sclerocornea (HP:0000647)2.15462507
65Occipital encephalocele (HP:0002085)2.15271727
66Enlarged epiphyses (HP:0010580)2.15246984
67Generalized aminoaciduria (HP:0002909)2.14331552
68Tetany (HP:0001281)2.12176809
69Cone-rod dystrophy (HP:0000548)2.10099105
70Congenital sensorineural hearing impairment (HP:0008527)2.09354335
71Amblyopia (HP:0000646)2.05282921
72Rhinitis (HP:0012384)2.04568312
73Keratoconus (HP:0000563)2.04368693
74Increased corneal curvature (HP:0100692)2.04368693
75Amelogenesis imperfecta (HP:0000705)2.04033922
76Lissencephaly (HP:0001339)1.99888464
77Abnormality of renal excretion (HP:0011036)1.99013032
78Cystic liver disease (HP:0006706)1.98240000
79Tubulointerstitial abnormality (HP:0001969)1.98099920
80Absent speech (HP:0001344)1.97400705
81Thyroiditis (HP:0100646)1.96970963
82Chronic sinusitis (HP:0011109)1.96755359
83Anencephaly (HP:0002323)1.93265485
84Poor coordination (HP:0002370)1.90753273
85Optic nerve hypoplasia (HP:0000609)1.90116587
86Abolished electroretinogram (ERG) (HP:0000550)1.89919556
87Abnormality of potassium homeostasis (HP:0011042)1.89556914
88Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.88067786
89Median cleft lip (HP:0000161)1.85471193
90Abnormality of the pubic bones (HP:0003172)1.83464537
91Tubular atrophy (HP:0000092)1.81072323
92Intestinal atresia (HP:0011100)1.80460332
93Hyperventilation (HP:0002883)1.80260694
94Male infertility (HP:0003251)1.79848854
95Nasal polyposis (HP:0100582)1.79244658
96Bronchiectasis (HP:0002110)1.77792736
973-Methylglutaconic aciduria (HP:0003535)1.77520206
98Abnormality of dental color (HP:0011073)1.77398392
99Photophobia (HP:0000613)1.76266922
100Postural instability (HP:0002172)1.75495527

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK45.26876601
2MAP4K25.12091458
3INSRR4.29867722
4TESK13.88965823
5FRK3.05668519
6DDR22.96634527
7PLK22.92804450
8BMPR1B2.52453374
9TESK22.23621287
10STK382.17696805
11MARK12.04657680
12GRK11.98199365
13TAOK31.93219064
14PRKD31.90249246
15CASK1.81277839
16ADRBK21.74670597
17STK38L1.72460408
18FER1.65494475
19MAPK151.65351580
20MAPK131.58101060
21WNK31.53389085
22PNCK1.38623221
23PIK3CG1.35851519
24MAP3K41.33854918
25FES1.31719097
26CAMK1G1.25132821
27BRD41.24534078
28TRIM281.23409207
29NUAK11.18510213
30MAP2K71.14097142
31WNK41.10287053
32AKT31.08394291
33ZAK1.02647232
34PTK2B1.00181869
35PRKCE0.99145676
36DYRK20.97037793
37PINK10.96913572
38UHMK10.95837532
39WNK10.91479137
40PDK10.89227931
41CAMK10.87003445
42CDK70.85588915
43STK160.83451979
44PRKCG0.83264370
45STK390.79935932
46ACVR1B0.79184815
47NTRK30.77369765
48TXK0.73768380
49DYRK1B0.67893553
50GRK50.66741256
51PDPK10.66412490
52MUSK0.66399082
53FLT30.65377749
54CAMK40.64425605
55DYRK30.64092689
56KIT0.62008628
57SIK20.61084128
58PRKAA20.60401803
59PRKG10.57739440
60NEK60.56583830
61CCNB10.54583363
62PRKCZ0.53626828
63MAPKAPK30.50978461
64MAP3K90.50412391
65OXSR10.49507899
66BCKDK0.49172411
67MAP2K20.49012851
68CAMK1D0.44909320
69MST1R0.44587761
70SGK4940.41508401
71SGK2230.41508401
72CSNK1G20.39834707
73VRK10.39232929
74PRKACA0.38855455
75RPS6KA40.35766548
76CAMK2A0.35479519
77CSNK1G30.33994478
78GRK60.32509583
79TAF10.31657266
80PRKCB0.30944084
81RPS6KA10.30134706
82TGFBR10.29446692
83SGK20.29020708
84TNK20.28792321
85PKN10.28547553
86PRKAA10.28530825
87PRKCQ0.27971944
88ROCK10.27725197
89MAPKAPK50.27308246
90CSNK1A10.26647858
91MINK10.26309578
92PAK30.25956592
93GSK3B0.24914645
94CSNK1A1L0.24824492
95PRKACB0.24673599
96DYRK1A0.24652051
97SGK10.23462274
98TIE10.23339326
99MET0.22787800
100ERBB30.22376280

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000726.42764499
2Fatty acid biosynthesis_Homo sapiens_hsa000613.56986176
3Olfactory transduction_Homo sapiens_hsa047403.17030331
4Butanoate metabolism_Homo sapiens_hsa006503.14215514
5Phototransduction_Homo sapiens_hsa047442.61750650
6Taste transduction_Homo sapiens_hsa047422.22719065
7Maturity onset diabetes of the young_Homo sapiens_hsa049501.99016593
8Nicotine addiction_Homo sapiens_hsa050331.94694628
9Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.87613037
10Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.85409843
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.76072491
12Type I diabetes mellitus_Homo sapiens_hsa049401.69652252
13Morphine addiction_Homo sapiens_hsa050321.61881039
14Linoleic acid metabolism_Homo sapiens_hsa005911.59214173
15Autoimmune thyroid disease_Homo sapiens_hsa053201.43270265
16Graft-versus-host disease_Homo sapiens_hsa053321.42553701
17Allograft rejection_Homo sapiens_hsa053301.40577634
18Glycerophospholipid metabolism_Homo sapiens_hsa005641.39083565
19GABAergic synapse_Homo sapiens_hsa047271.34764212
20Synaptic vesicle cycle_Homo sapiens_hsa047211.31867313
21Dorso-ventral axis formation_Homo sapiens_hsa043201.31524034
22Retinol metabolism_Homo sapiens_hsa008301.31495263
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.31417967
24ABC transporters_Homo sapiens_hsa020101.30956543
25Selenocompound metabolism_Homo sapiens_hsa004501.29157566
26Circadian entrainment_Homo sapiens_hsa047131.27311523
27Type II diabetes mellitus_Homo sapiens_hsa049301.26478818
28Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.26014636
29Nitrogen metabolism_Homo sapiens_hsa009101.25032815
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.23186692
31Peroxisome_Homo sapiens_hsa041461.21451774
32Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.18696017
33Glutamatergic synapse_Homo sapiens_hsa047241.17313537
34Salivary secretion_Homo sapiens_hsa049701.16663092
35Fatty acid degradation_Homo sapiens_hsa000711.10987555
36Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.09608828
37Antigen processing and presentation_Homo sapiens_hsa046121.09293360
38Arginine and proline metabolism_Homo sapiens_hsa003301.04502464
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.00953832
40Basal transcription factors_Homo sapiens_hsa030220.97100269
41Calcium signaling pathway_Homo sapiens_hsa040200.95366892
42Primary bile acid biosynthesis_Homo sapiens_hsa001200.95300936
43Fat digestion and absorption_Homo sapiens_hsa049750.94382454
44Fatty acid metabolism_Homo sapiens_hsa012120.93136967
45Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.91543135
46Caffeine metabolism_Homo sapiens_hsa002320.91058614
47Steroid hormone biosynthesis_Homo sapiens_hsa001400.90613906
48Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.87847871
49Propanoate metabolism_Homo sapiens_hsa006400.87025594
50RNA polymerase_Homo sapiens_hsa030200.86950196
51Insulin secretion_Homo sapiens_hsa049110.86015183
52Hedgehog signaling pathway_Homo sapiens_hsa043400.78273117
53Glycerolipid metabolism_Homo sapiens_hsa005610.75625175
54Regulation of autophagy_Homo sapiens_hsa041400.74880458
55Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.72161670
56Fanconi anemia pathway_Homo sapiens_hsa034600.71690608
57cAMP signaling pathway_Homo sapiens_hsa040240.71550219
58Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70131972
59Ether lipid metabolism_Homo sapiens_hsa005650.70076426
60Aldosterone synthesis and secretion_Homo sapiens_hsa049250.70004560
61Chemical carcinogenesis_Homo sapiens_hsa052040.69147205
62RNA transport_Homo sapiens_hsa030130.66396147
63Purine metabolism_Homo sapiens_hsa002300.64125230
64Cardiac muscle contraction_Homo sapiens_hsa042600.63549001
65Endocytosis_Homo sapiens_hsa041440.61600947
66Tryptophan metabolism_Homo sapiens_hsa003800.61537440
67Serotonergic synapse_Homo sapiens_hsa047260.61389942
68Primary immunodeficiency_Homo sapiens_hsa053400.60984417
69Arginine biosynthesis_Homo sapiens_hsa002200.58856931
70Renin secretion_Homo sapiens_hsa049240.58613007
71Huntingtons disease_Homo sapiens_hsa050160.55347549
72Pentose and glucuronate interconversions_Homo sapiens_hsa000400.55232370
73Viral myocarditis_Homo sapiens_hsa054160.54168609
74Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.52834127
75Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.52672567
76Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.49735403
77Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.49397119
78Gastric acid secretion_Homo sapiens_hsa049710.48268551
79Inositol phosphate metabolism_Homo sapiens_hsa005620.45723858
80Collecting duct acid secretion_Homo sapiens_hsa049660.45424188
81Oocyte meiosis_Homo sapiens_hsa041140.45357814
82PPAR signaling pathway_Homo sapiens_hsa033200.45235465
83Adipocytokine signaling pathway_Homo sapiens_hsa049200.45156038
84Metabolic pathways_Homo sapiens_hsa011000.44978305
85Amphetamine addiction_Homo sapiens_hsa050310.44186529
86Cholinergic synapse_Homo sapiens_hsa047250.44147829
87Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43865541
88Steroid biosynthesis_Homo sapiens_hsa001000.42949024
89Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41057966
90Intestinal immune network for IgA production_Homo sapiens_hsa046720.39829402
91Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.38522407
92Dopaminergic synapse_Homo sapiens_hsa047280.38159986
93beta-Alanine metabolism_Homo sapiens_hsa004100.37636709
94Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.36637443
95Oxytocin signaling pathway_Homo sapiens_hsa049210.36402732
96Carbohydrate digestion and absorption_Homo sapiens_hsa049730.35540384
97Arachidonic acid metabolism_Homo sapiens_hsa005900.35352739
98Vascular smooth muscle contraction_Homo sapiens_hsa042700.33799739
99Circadian rhythm_Homo sapiens_hsa047100.33336715
100Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.33320619

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