VN1R42P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil mediated immunity (GO:0002446)9.99001521
2ether lipid metabolic process (GO:0046485)9.86278469
3positive regulation of chemokine biosynthetic process (GO:0045080)9.86211416
4positive regulation of interleukin-8 biosynthetic process (GO:0045416)9.32039681
5pyrimidine deoxyribonucleotide catabolic process (GO:0009223)8.95015792
6microglial cell activation (GO:0001774)8.83872410
7regulation of MHC class II biosynthetic process (GO:0045346)8.70345985
8pyrimidine nucleotide catabolic process (GO:0006244)8.13473757
9myeloid leukocyte mediated immunity (GO:0002444)7.36241826
10modulation of growth of symbiont involved in interaction with host (GO:0044144)6.94196774
11regulation of growth of symbiont in host (GO:0044126)6.94196774
12negative regulation of growth of symbiont in host (GO:0044130)6.94196774
13negative regulation of growth of symbiont involved in interaction with host (GO:0044146)6.94196774
14induction of positive chemotaxis (GO:0050930)6.38132121
15alanine transport (GO:0032328)6.26365392
16striated muscle atrophy (GO:0014891)6.25331227
17macrophage chemotaxis (GO:0048246)6.17106602
18regulation of tumor necrosis factor biosynthetic process (GO:0042534)6.06860219
19L-serine transport (GO:0015825)6.01784416
20negative regulation of interleukin-8 production (GO:0032717)5.91315553
21regulation of interleukin-8 biosynthetic process (GO:0045414)5.87050865
22glial cell migration (GO:0008347)5.85101908
23pyrimidine deoxyribonucleotide metabolic process (GO:0009219)5.67568756
24skeletal muscle adaptation (GO:0043501)5.61549647
25glycerol ether metabolic process (GO:0006662)5.56543784
26muscle atrophy (GO:0014889)5.41281117
27serine transport (GO:0032329)5.21703804
28ether metabolic process (GO:0018904)5.14372809
29negative regulation of chemokine production (GO:0032682)4.86053310
30deoxyribonucleotide catabolic process (GO:0009264)4.82677786
31killing of cells of other organism (GO:0031640)4.71360664
32disruption of cells of other organism (GO:0044364)4.71360664
33histone deubiquitination (GO:0016578)4.70004777
34deoxyribose phosphate catabolic process (GO:0046386)4.56986927
35L-alpha-amino acid transmembrane transport (GO:1902475)4.48765583
36macrophage activation (GO:0042116)4.30728303
37C4-dicarboxylate transport (GO:0015740)4.28088044
38negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)4.22454468
39membrane protein intracellular domain proteolysis (GO:0031293)4.10267423
40protein localization to microtubule (GO:0035372)3.99359048
41leukocyte mediated cytotoxicity (GO:0001909)3.93853346
42cellular response to exogenous dsRNA (GO:0071360)3.74619071
43modification by host of symbiont morphology or physiology (GO:0051851)3.68030541
44negative regulation of DNA-templated transcription, elongation (GO:0032785)3.67926596
45positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.61603851
46regulation of triglyceride catabolic process (GO:0010896)3.56197959
47protein kinase C-activating G-protein coupled receptor signaling pathway (GO:0007205)3.54570222
48positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.51347733
49oxidative demethylation (GO:0070989)3.47925586
50positive regulation of interleukin-1 beta production (GO:0032731)3.44244153
51negative regulation of phagocytosis (GO:0050765)3.43985552
52basic amino acid transport (GO:0015802)3.40008033
53interaction with symbiont (GO:0051702)3.38950510
54regulation of double-strand break repair via homologous recombination (GO:0010569)3.37197578
55ventricular system development (GO:0021591)3.33826395
56negative regulation of skeletal muscle tissue development (GO:0048642)3.31527595
57positive regulation of positive chemotaxis (GO:0050927)3.29742631
58inflammatory response to antigenic stimulus (GO:0002437)3.28047685
59mitotic chromosome condensation (GO:0007076)3.24394577
60response to fungus (GO:0009620)3.23038361
61positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc3.21410758
62regulation of vascular permeability (GO:0043114)3.20763726
63positive regulation of cytokine biosynthetic process (GO:0042108)3.20583912
64genetic imprinting (GO:0071514)3.14218689
65defense response to Gram-negative bacterium (GO:0050829)3.13143410
66regulation of positive chemotaxis (GO:0050926)3.13070924
67positive regulation of interleukin-1 production (GO:0032732)3.10494376
68regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 3.04241406
69regulation of chemokine production (GO:0032642)3.01468148
70regulation of transcription elongation from RNA polymerase II promoter (GO:0034243)2.97091516
71protein targeting to Golgi (GO:0000042)2.92613766
72DNA methylation involved in gamete generation (GO:0043046)2.92036952
73membrane protein ectodomain proteolysis (GO:0006509)2.91289547
74peroxisome fission (GO:0016559)2.89624687
75DNA ligation (GO:0006266)2.86994822
762-deoxyribonucleotide metabolic process (GO:0009394)2.84204549
77valine metabolic process (GO:0006573)2.81755870
78positive regulation of peptidyl-threonine phosphorylation (GO:0010800)2.78221999
79positive regulation of B cell differentiation (GO:0045579)2.77161543
80ectodermal placode formation (GO:0060788)2.75356995
81DNA dealkylation (GO:0035510)2.75200569
82folic acid-containing compound biosynthetic process (GO:0009396)2.72698427
83establishment of protein localization to Golgi (GO:0072600)2.72539150
84cytoplasmic microtubule organization (GO:0031122)2.72392227
85angiotensin maturation (GO:0002003)2.70994562
86negative regulation of histone acetylation (GO:0035067)2.63782932
87deoxyribose phosphate metabolic process (GO:0019692)2.62887349
88positive regulation of chemokine production (GO:0032722)2.60504547
89positive regulation of developmental pigmentation (GO:0048087)2.58242277
90phagocytosis (GO:0006909)2.57656853
91retrograde transport, vesicle recycling within Golgi (GO:0000301)2.57482666
92positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.57287998
93DNA demethylation (GO:0080111)2.54450707
94deoxyribose phosphate biosynthetic process (GO:0046385)2.53349253
952-deoxyribonucleotide biosynthetic process (GO:0009265)2.53349253
96cellular extravasation (GO:0045123)15.1024005
97regulation of chemokine biosynthetic process (GO:0045073)13.2373886
98disruption of cells of other organism involved in symbiotic interaction (GO:0051818)10.8263223
99killing of cells in other organism involved in symbiotic interaction (GO:0051883)10.8263223
100positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)10.1729599

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.84373945
2STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse7.79266689
3AR_21572438_ChIP-Seq_LNCaP_Human6.79611984
4SCL_19346495_ChIP-Seq_HPC-7_Human4.98461560
5VDR_21846776_ChIP-Seq_THP-1_Human4.16602961
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.63226428
7ELF1_17652178_ChIP-ChIP_JURKAT_Human3.35660863
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.91153757
9FOXM1_23109430_ChIP-Seq_U2OS_Human2.64167543
10GATA1_22025678_ChIP-Seq_K562_Human2.18839223
11VDR_24763502_ChIP-Seq_THP-1_Human2.05569774
12POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.05037723
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.02478802
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.91974583
15MYC_22102868_ChIP-Seq_BL_Human1.88393005
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.71163920
17MAF_26560356_Chip-Seq_TH2_Human1.70480382
18TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62087377
19MYB_26560356_Chip-Seq_TH1_Human1.57305144
20MYC_18555785_ChIP-Seq_MESCs_Mouse1.56943821
21CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.49407596
22CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.45288596
23AR_21909140_ChIP-Seq_LNCAP_Human1.45181677
24VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.44580765
25UTX_26944678_Chip-Seq_JUKART_Human1.42702579
26PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.42398721
27MAF_26560356_Chip-Seq_TH1_Human1.40706251
28SPI1_23547873_ChIP-Seq_NB4_Human1.35582168
29SPI1_20517297_ChIP-Seq_HL60_Human1.33645540
30MYB_26560356_Chip-Seq_TH2_Human1.29947791
31GATA1_19941827_ChIP-Seq_MEL_Mouse1.29194675
32MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.28722918
33BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.28717066
34XRN2_22483619_ChIP-Seq_HELA_Human1.28069006
35AUTS2_25519132_ChIP-Seq_293T-REX_Human1.25926159
36PADI4_21655091_ChIP-ChIP_MCF-7_Human1.21669870
37GATA1_19941826_ChIP-Seq_K562_Human1.21653682
38MYB_21317192_ChIP-Seq_ERMYB_Mouse1.18141288
39MYC_18358816_ChIP-ChIP_MESCs_Mouse1.17589306
40E2F1_21310950_ChIP-Seq_MCF-7_Human1.17497263
41GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13356760
42FOXP3_21729870_ChIP-Seq_TREG_Human1.12376816
43CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.10286604
44VDR_23849224_ChIP-Seq_CD4+_Human1.10071384
45IRF8_22096565_ChIP-ChIP_GC-B_Human1.08224239
46SOX2_22085726_ChIP-Seq_NPCs_Mouse1.07648079
47EGR1_23403033_ChIP-Seq_LIVER_Mouse1.03499862
48GATA2_19941826_ChIP-Seq_K562_Human1.03321095
49TET1_21451524_ChIP-Seq_MESCs_Mouse1.03018587
50GATA2_22383799_ChIP-Seq_G1ME_Mouse1.02282100
51HIF1A_21447827_ChIP-Seq_MCF-7_Human1.01227771
52ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.01163560
53EGR1_19032775_ChIP-ChIP_M12_Human1.01084492
54E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.00777980
55GATA1_22383799_ChIP-Seq_G1ME_Mouse1.00342636
56GATA3_21867929_ChIP-Seq_CD8_Mouse0.99706151
57CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.99435292
58MYCN_18555785_ChIP-Seq_MESCs_Mouse0.98222033
59ERG_20887958_ChIP-Seq_HPC-7_Mouse0.97174994
60NCOR1_26117541_ChIP-Seq_K562_Human0.96257677
61MYC_19079543_ChIP-ChIP_MESCs_Mouse0.96107163
62GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95122790
63KDM5A_27292631_Chip-Seq_BREAST_Human0.95046067
64CIITA_25753668_ChIP-Seq_RAJI_Human0.95035476
65SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.94330056
66CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91619176
67RARB_24833708_ChIP-Seq_LIVER_Mouse0.90788158
68RUNX1_22412390_ChIP-Seq_EML_Mouse0.90651054
69TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.89145896
70RBPJ_22232070_ChIP-Seq_NCS_Mouse0.87557589
71ELF1_20517297_ChIP-Seq_JURKAT_Human0.87249466
72TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.85624442
73FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.83427335
74SRY_22984422_ChIP-ChIP_TESTIS_Rat0.82965930
75HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.82939526
76CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.82924281
77BRD4_27068464_Chip-Seq_AML-cells_Mouse0.81503317
78MYC_18940864_ChIP-ChIP_HL60_Human0.80901338
79SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.79333819
80IGF1R_20145208_ChIP-Seq_DFB_Human0.79246103
81GABP_19822575_ChIP-Seq_HepG2_Human0.78435484
82DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.78285204
83HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.78199855
84SA1_27219007_Chip-Seq_ERYTHROID_Human0.78176297
85MYC_19030024_ChIP-ChIP_MESCs_Mouse0.77176616
86RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.76507760
87HOXB4_20404135_ChIP-ChIP_EML_Mouse0.76348110
88GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.74269312
89TP53_22573176_ChIP-Seq_HFKS_Human0.74190664
90NELFA_20434984_ChIP-Seq_ESCs_Mouse0.73965584
91GATA3_26560356_Chip-Seq_TH1_Human0.73916053
92KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.73853627
93PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.73780393
94ETS1_22383799_ChIP-Seq_G1ME_Mouse0.73552012
95EST1_17652178_ChIP-ChIP_JURKAT_Human0.73527600
96TCF7_22412390_ChIP-Seq_EML_Mouse0.72983016
97TP63_19390658_ChIP-ChIP_HaCaT_Human0.72590012
98STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.72436034
99TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.72391419
100SALL1_21062744_ChIP-ChIP_HESCs_Human0.71714434

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003123_paternal_imprinting7.24756321
2MP0008877_abnormal_DNA_methylation5.45182015
3MP0003878_abnormal_ear_physiology4.60726988
4MP0005377_hearing/vestibular/ear_phenot4.60726988
5MP0003950_abnormal_plasma_membrane3.90854846
6MP0005076_abnormal_cell_differentiation3.75161356
7MP0000537_abnormal_urethra_morphology3.72497620
8MP0003303_peritoneal_inflammation3.62953943
9MP0003122_maternal_imprinting3.47743013
10MP0008057_abnormal_DNA_replication3.47056202
11MP0005075_abnormal_melanosome_morpholog3.22898020
12MP0003121_genomic_imprinting3.11664620
13MP0000372_irregular_coat_pigmentation2.56088536
14MP0001727_abnormal_embryo_implantation2.47420872
15MP0005174_abnormal_tail_pigmentation2.46383769
16MP0000015_abnormal_ear_pigmentation2.22630639
17MP0005083_abnormal_biliary_tract2.09539134
18MP0009672_abnormal_birth_weight2.00144663
19MP0000569_abnormal_digit_pigmentation1.99589470
20MP0003787_abnormal_imprinting1.97254647
21MP0004130_abnormal_muscle_cell1.89319222
22MP0009697_abnormal_copulation1.86078901
23MP0009278_abnormal_bone_marrow1.78808735
24MP0003718_maternal_effect1.73439241
25MP0010094_abnormal_chromosome_stability1.71717927
26MP0002095_abnormal_skin_pigmentation1.68053423
27MP0002332_abnormal_exercise_endurance1.51708268
28MP0005464_abnormal_platelet_physiology1.49827723
29MP0004381_abnormal_hair_follicle1.42388238
30MP0005397_hematopoietic_system_phenotyp1.41234433
31MP0001545_abnormal_hematopoietic_system1.41234433
32MP0001188_hyperpigmentation1.39723247
33MP0004084_abnormal_cardiac_muscle1.34905883
34MP0002396_abnormal_hematopoietic_system1.28160955
35MP0004147_increased_porphyrin_level1.25874134
36MP0001986_abnormal_taste_sensitivity1.25694719
37MP0009785_altered_susceptibility_to1.22014292
38MP0004808_abnormal_hematopoietic_stem1.17270888
39MP0004233_abnormal_muscle_weight1.13657165
40MP0003195_calcinosis1.12485809
41MP0000013_abnormal_adipose_tissue1.10145352
42MP0003646_muscle_fatigue1.06895600
43MP0002877_abnormal_melanocyte_morpholog0.99583020
44MP0003656_abnormal_erythrocyte_physiolo0.99530290
45MP0001293_anophthalmia0.98375943
46MP0003136_yellow_coat_color0.97348901
47MP0009379_abnormal_foot_pigmentation0.94065078
48MP0009703_decreased_birth_body0.93362469
49MP0004036_abnormal_muscle_relaxation0.91311886
50MP0003172_abnormal_lysosome_physiology0.91235895
51MP0004883_abnormal_blood_vessel0.90511419
52MP0002638_abnormal_pupillary_reflex0.87491078
53MP0001485_abnormal_pinna_reflex0.86825059
54MP0004185_abnormal_adipocyte_glucose0.86481069
55MP0003943_abnormal_hepatobiliary_system0.86043771
56MP0001853_heart_inflammation0.84302299
57MP0008007_abnormal_cellular_replicative0.83940848
58MP0004145_abnormal_muscle_electrophysio0.83714936
59MP0005266_abnormal_metabolism0.83489425
60MP0000003_abnormal_adipose_tissue0.82588247
61MP0001486_abnormal_startle_reflex0.82089121
62MP0005025_abnormal_response_to0.82074703
63MP0002419_abnormal_innate_immunity0.81468486
64MP0003111_abnormal_nucleus_morphology0.78491645
65MP0005197_abnormal_uvea_morphology0.77094088
66MP0005167_abnormal_blood-brain_barrier0.72604418
67MP0000371_diluted_coat_color0.70582546
68MP0004957_abnormal_blastocyst_morpholog0.69449885
69MP0005409_darkened_coat_color0.68678882
70MP0009046_muscle_twitch0.67770525
71MP0005451_abnormal_body_composition0.63854888
72MP0006292_abnormal_olfactory_placode0.61155871
73MP0003638_abnormal_response/metabolism_0.58508156
74MP0004197_abnormal_fetal_growth/weight/0.58114912
75MP0005375_adipose_tissue_phenotype0.54648153
76MP0002971_abnormal_brown_adipose0.54259390
77MP0008961_abnormal_basal_metabolism0.54092752
78MP0003077_abnormal_cell_cycle0.53682720
79MP0002398_abnormal_bone_marrow0.52084750
80MP0002019_abnormal_tumor_incidence0.52063884
81MP0009333_abnormal_splenocyte_physiolog0.51488622
82MP0008932_abnormal_embryonic_tissue0.50520689
83MP0001915_intracranial_hemorrhage0.50299254
84MP0000428_abnormal_craniofacial_morphol0.49270465
85MP0005164_abnormal_response_to0.48985528
86MP0003959_abnormal_lean_body0.48277867
87MP0002420_abnormal_adaptive_immunity0.46980869
88MP0005395_other_phenotype0.46280326
89MP0009764_decreased_sensitivity_to0.45105668
90MP0005535_abnormal_body_temperature0.44827353
91MP0001819_abnormal_immune_cell0.44664463
92MP0001440_abnormal_grooming_behavior0.44578826
93MP0002722_abnormal_immune_system0.44459638
94MP0008874_decreased_physiological_sensi0.43490379
95MP0005666_abnormal_adipose_tissue0.42503601
96MP0005220_abnormal_exocrine_pancreas0.42444058
97MP0005000_abnormal_immune_tolerance0.42392401
98MP0003693_abnormal_embryo_hatching0.42325019
99MP0005376_homeostasis/metabolism_phenot0.42194558
100MP0004782_abnormal_surfactant_physiolog0.41915567

Predicted human phenotypes

RankGene SetZ-score
1Genetic anticipation (HP:0003743)7.31781970
2Eosinophilia (HP:0001880)7.17436801
3Congenital stationary night blindness (HP:0007642)7.12194261
4Periodontitis (HP:0000704)6.93042681
5Pigmentary retinal degeneration (HP:0001146)6.64982624
6Difficulty running (HP:0009046)6.53305502
7Granulocytopenia (HP:0001913)6.41410811
8Abnormality of eosinophils (HP:0001879)5.40940434
9Slow saccadic eye movements (HP:0000514)5.24008952
10Subacute progressive viral hepatitis (HP:0006572)5.16622021
11Progressive cerebellar ataxia (HP:0002073)5.01852995
12Dyskinesia (HP:0100660)4.54356121
13Macular degeneration (HP:0000608)4.14928442
14Hypergammaglobulinemia (HP:0010702)4.02140679
15Leukocytosis (HP:0001974)3.79862620
16Decreased central vision (HP:0007663)3.63627721
17Hypobetalipoproteinemia (HP:0003563)3.58607175
18Viral hepatitis (HP:0006562)3.54935977
19Cone-rod dystrophy (HP:0000548)3.49491221
20Ureteral duplication (HP:0000073)3.38077296
21Ureteral stenosis (HP:0000071)3.28932112
22Ureteral obstruction (HP:0006000)3.10713436
23Fair hair (HP:0002286)3.04092886
24Asymmetric septal hypertrophy (HP:0001670)2.98043249
25Hypoplasia of the capital femoral epiphysis (HP:0003090)2.82487727
26Neonatal hypoglycemia (HP:0001998)2.81904224
27Progressive visual loss (HP:0000529)2.77514479
28Micronodular cirrhosis (HP:0001413)2.76412900
29Loss of speech (HP:0002371)2.75218168
30Ocular albinism (HP:0001107)2.69663061
31Acanthocytosis (HP:0001927)2.68134859
32Generalized hypopigmentation of hair (HP:0011358)2.65513836
33Hyperventilation (HP:0002883)2.63832583
34Albinism (HP:0001022)2.63456182
35Abnormality of the musculature of the hand (HP:0001421)2.60422854
36Abnormality of the prostate (HP:0008775)2.52590640
37Annular pancreas (HP:0001734)2.44651175
38Brushfield spots (HP:0001088)2.37385897
39Cholecystitis (HP:0001082)2.33414226
40Abnormal gallbladder physiology (HP:0012438)2.33414226
41Autoimmune thrombocytopenia (HP:0001973)2.33055649
42Abnormality of the fingertips (HP:0001211)2.25590471
43Hepatocellular carcinoma (HP:0001402)2.24666603
44Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.24240035
45Absent epiphyses (HP:0010577)2.24240035
46Cortical visual impairment (HP:0100704)2.23105017
47Rough bone trabeculation (HP:0100670)2.22666819
48Epileptic encephalopathy (HP:0200134)2.22067356
49Abnormality of saccadic eye movements (HP:0000570)2.20469340
50Premature graying of hair (HP:0002216)2.18584700
51Type I transferrin isoform profile (HP:0003642)2.18447942
52Iris hypopigmentation (HP:0007730)2.13376035
53Akinesia (HP:0002304)2.13102606
54Poikilocytosis (HP:0004447)2.11925279
55Polyneuropathy (HP:0001271)2.11838682
56Acute myeloid leukemia (HP:0004808)2.11799905
57Chromsome breakage (HP:0040012)2.11258153
58Recurrent gram-negative bacterial infections (HP:0005420)2.09168938
59Tubulointerstitial nephritis (HP:0001970)2.04640437
60Blue irides (HP:0000635)2.02205459
61Amelogenesis imperfecta (HP:0000705)2.01831578
62Poor speech (HP:0002465)2.01716310
63Thrombocytosis (HP:0001894)10.0938076
64Progressive hearing impairment (HP:0001730)1.97442796
65Selective tooth agenesis (HP:0001592)1.96565467
66Sepsis (HP:0100806)1.95917324
67Abnormality of dental color (HP:0011073)1.94148030
68Generalized hyperpigmentation (HP:0007440)1.92854423
69Short chin (HP:0000331)1.92002178
70Widely spaced teeth (HP:0000687)1.91668661
71Pseudobulbar signs (HP:0002200)1.91502400
72Neutropenia (HP:0001875)1.90046875
73Thickened nuchal skin fold (HP:0000474)1.89315762
74Capillary hemangiomas (HP:0005306)1.85527943
75Obstructive lung disease (HP:0006536)1.84881931
76Chronic obstructive pulmonary disease (HP:0006510)1.84881931
77Abnormal protein glycosylation (HP:0012346)1.84777010
78Abnormal glycosylation (HP:0012345)1.84777010
79Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.84777010
80Abnormal protein N-linked glycosylation (HP:0012347)1.84777010
81Acute lymphatic leukemia (HP:0006721)1.83978368
82Epiphyseal stippling (HP:0010655)1.81617141
83J-shaped sella turcica (HP:0002680)1.80659012
84Premature skin wrinkling (HP:0100678)1.79512993
85Cerebellar hypoplasia (HP:0001321)1.79339371
86Hypochromic anemia (HP:0001931)1.78965160
87Abnormality of male internal genitalia (HP:0000022)1.78872684
88Cellular immunodeficiency (HP:0005374)1.76948932
89High anterior hairline (HP:0009890)1.76574821
90Abnormal pancreas size (HP:0012094)1.75818484
91Limb hypertonia (HP:0002509)1.73965752
92Lower limb muscle weakness (HP:0007340)1.72816399
93Chronic sinusitis (HP:0011109)1.70406282
94Difficulty walking (HP:0002355)1.70046637
95Postnatal microcephaly (HP:0005484)1.69376852
96Abnormality of the columella (HP:0009929)1.68582041
97Clumsiness (HP:0002312)1.67712008
98Partial agenesis of the corpus callosum (HP:0001338)1.67185417
99Central scotoma (HP:0000603)1.66693456
100Dyschromatopsia (HP:0007641)1.65573251

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK35.59053982
2PIK3CG4.77534253
3IRAK34.50347064
4ICK3.73782727
5IRAK23.63070169
6ERN13.56824861
7PBK3.21032087
8PIK3CA2.73910059
9CCNB12.43448371
10MAP3K22.36717019
11IRAK12.36306720
12CDK122.30088353
13NEK22.26968687
14TYK22.12128656
15KSR22.06858149
16IRAK41.96929428
17MST41.86871369
18RPS6KA41.81028936
19EEF2K1.64065012
20ATR1.61427384
21RIPK41.57877709
22MUSK1.52617517
23PTK2B1.44656541
24STK381.37435441
25ZAP701.36068392
26PRKG21.31809023
27RPS6KB21.28134108
28TAOK31.14432973
29MATK1.08411042
30PLK21.07519703
31MAP3K41.05458766
32KIT0.97067062
33CHEK10.95960844
34NEK60.93386962
35SCYL20.92764270
36MAPK110.92152538
37TTK0.90494409
38OBSCN0.84962139
39TRPM70.84771861
40YES10.82433432
41MAPK40.81227375
42LCK0.80583760
43TAOK10.80002066
44MAP3K100.78471962
45HIPK20.78151149
46CDK20.73966662
47PRKAA10.73511790
48SRPK10.72102853
49PLK40.68616669
50PLK10.66154605
51MTOR0.64681691
52CDK10.63592638
53SYK0.62031666
54CHEK20.61004185
55PRKAA20.60427808
56BMPR20.58818897
57TYRO30.58304174
58VRK10.57943689
59GSK3B0.56058713
60MAPK140.55777496
61CSNK2A20.55663270
62RPS6KB10.55519935
63RPS6KA10.52988794
64TRIB30.48754812
65AURKB0.48652645
66RPS6KA50.48185776
67HCK0.46306159
68MAPK80.45715898
69AKT10.45611687
70WEE10.44916503
71RET0.44871526
72PRKCI0.43384151
73CDC70.43159931
74IKBKE0.42292787
75JAK20.41475790
76FLT30.41270296
77BRD40.39558596
78CSNK2A10.38060780
79TAOK20.36151361
80BMX0.35458095
81RPS6KA60.35070292
82CDC42BPA0.34955696
83RPS6KA30.34353939
84CSNK1E0.33809298
85PTK60.33361906
86MKNK20.32674209
87BTK0.32660574
88EGFR0.31260419
89PDGFRB0.31219428
90GRK60.31203894
91NUAK10.31154992
92CLK10.30147088
93MKNK10.28974884
94RPS6KC10.28097226
95RPS6KL10.28097226
96IGF1R0.27235949
97CSF1R0.25886750
98MAP3K10.25662851
99CSK0.25178374
100MAPK30.25083109

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034506.30873245
2Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007604.10093272
3Ether lipid metabolism_Homo sapiens_hsa005653.67983043
4DNA replication_Homo sapiens_hsa030303.53542138
5Base excision repair_Homo sapiens_hsa034102.73363842
6Nucleotide excision repair_Homo sapiens_hsa034202.35843423
7Renin-angiotensin system_Homo sapiens_hsa046142.23399243
8Endometrial cancer_Homo sapiens_hsa052132.03971114
9Transcriptional misregulation in cancer_Homo sapiens_hsa052021.92462251
10Acute myeloid leukemia_Homo sapiens_hsa052211.84843429
11Glycosaminoglycan degradation_Homo sapiens_hsa005311.83909915
12Pyrimidine metabolism_Homo sapiens_hsa002401.83602402
13Systemic lupus erythematosus_Homo sapiens_hsa053221.74036066
14Ribosome_Homo sapiens_hsa030101.70862351
15Folate biosynthesis_Homo sapiens_hsa007901.67344465
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.62645992
17Notch signaling pathway_Homo sapiens_hsa043301.47053841
18Basal cell carcinoma_Homo sapiens_hsa052171.42588818
19Carbohydrate digestion and absorption_Homo sapiens_hsa049731.39716264
20Chronic myeloid leukemia_Homo sapiens_hsa052201.36424455
21Non-small cell lung cancer_Homo sapiens_hsa052231.36109460
22Other glycan degradation_Homo sapiens_hsa005111.33939577
23Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.31024814
24Colorectal cancer_Homo sapiens_hsa052101.29067930
25Amoebiasis_Homo sapiens_hsa051461.27348971
26B cell receptor signaling pathway_Homo sapiens_hsa046621.23611544
27mTOR signaling pathway_Homo sapiens_hsa041501.22946244
28Arginine biosynthesis_Homo sapiens_hsa002201.22102429
29Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.19874748
30Mismatch repair_Homo sapiens_hsa034301.17549229
31Homologous recombination_Homo sapiens_hsa034401.14278503
32Collecting duct acid secretion_Homo sapiens_hsa049661.13243215
33Phosphatidylinositol signaling system_Homo sapiens_hsa040701.04920512
34Sphingolipid metabolism_Homo sapiens_hsa006000.96525421
35Type II diabetes mellitus_Homo sapiens_hsa049300.94515328
36Platelet activation_Homo sapiens_hsa046110.94389102
37Pyruvate metabolism_Homo sapiens_hsa006200.94292479
38Toll-like receptor signaling pathway_Homo sapiens_hsa046200.93415567
39Jak-STAT signaling pathway_Homo sapiens_hsa046300.93198167
40Glioma_Homo sapiens_hsa052140.92272850
41Measles_Homo sapiens_hsa051620.91488918
42Hepatitis C_Homo sapiens_hsa051600.91393304
43Basal transcription factors_Homo sapiens_hsa030220.89645175
44Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.88221085
45VEGF signaling pathway_Homo sapiens_hsa043700.87722273
46Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.86247708
47Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.85284564
48Purine metabolism_Homo sapiens_hsa002300.84207492
49Choline metabolism in cancer_Homo sapiens_hsa052310.81489462
50Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.81341328
51RNA polymerase_Homo sapiens_hsa030200.80273106
52Glycerolipid metabolism_Homo sapiens_hsa005610.79885821
53ErbB signaling pathway_Homo sapiens_hsa040120.78409658
54Dorso-ventral axis formation_Homo sapiens_hsa043200.74714696
55Viral carcinogenesis_Homo sapiens_hsa052030.74178054
56Cysteine and methionine metabolism_Homo sapiens_hsa002700.72873889
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.72829451
58Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.71513286
59Melanoma_Homo sapiens_hsa052180.70527945
60Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.69526899
61Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.68313627
62Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.66835142
63Renal cell carcinoma_Homo sapiens_hsa052110.63198966
64RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.63073418
65Inositol phosphate metabolism_Homo sapiens_hsa005620.62519068
66Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.61839545
67HIF-1 signaling pathway_Homo sapiens_hsa040660.60487548
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.59037616
69Cyanoamino acid metabolism_Homo sapiens_hsa004600.57463922
70Wnt signaling pathway_Homo sapiens_hsa043100.57130058
71Glycerophospholipid metabolism_Homo sapiens_hsa005640.56145117
72Hematopoietic cell lineage_Homo sapiens_hsa046400.54584333
73Prolactin signaling pathway_Homo sapiens_hsa049170.52935228
74RNA transport_Homo sapiens_hsa030130.52684118
75Phospholipase D signaling pathway_Homo sapiens_hsa040720.52366214
76Hepatitis B_Homo sapiens_hsa051610.51708110
77African trypanosomiasis_Homo sapiens_hsa051430.48756406
78Central carbon metabolism in cancer_Homo sapiens_hsa052300.47736862
79AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.47668757
80Cell cycle_Homo sapiens_hsa041100.47379818
81Influenza A_Homo sapiens_hsa051640.45977759
82Insulin signaling pathway_Homo sapiens_hsa049100.44801062
83Linoleic acid metabolism_Homo sapiens_hsa005910.43714852
84Pancreatic cancer_Homo sapiens_hsa052120.43131686
85NF-kappa B signaling pathway_Homo sapiens_hsa040640.41623622
86MicroRNAs in cancer_Homo sapiens_hsa052060.39980269
87Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.39569749
88Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.37695156
89Oocyte meiosis_Homo sapiens_hsa041140.37077917
90Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.37028764
91Vitamin digestion and absorption_Homo sapiens_hsa049770.33311982
92Complement and coagulation cascades_Homo sapiens_hsa046100.33064133
93Osteoclast differentiation_Homo sapiens_hsa043800.30191396
94Prostate cancer_Homo sapiens_hsa052150.28386764
95Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.27238870
96Small cell lung cancer_Homo sapiens_hsa052220.27130988
97T cell receptor signaling pathway_Homo sapiens_hsa046600.26998003
98Pentose phosphate pathway_Homo sapiens_hsa000300.26925666
99Sphingolipid signaling pathway_Homo sapiens_hsa040710.26744684
100One carbon pool by folate_Homo sapiens_hsa006700.24915893

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