ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	positive regulation of male gonad development (GO:2000020)	8.53792542
2	negative regulation of metanephros development (GO:0072217)	7.79968066
3	regulation of male gonad development (GO:2000018)	7.30255088
4	fusion of sperm to egg plasma membrane (GO:0007342)	6.76726669
5	seminiferous tubule development (GO:0072520)	6.68015477
6	cellular response to gonadotropin stimulus (GO:0071371)	6.40726953
7	protein-chromophore linkage (GO:0018298)	5.42500805
8	negative regulation of mesenchymal cell apoptotic process (GO:2001054)	5.37304652
9	short-chain fatty acid metabolic process (GO:0046459)	5.13679674
10	plasma membrane fusion (GO:0045026)	5.00513015
11	metanephric mesenchyme development (GO:0072075)	4.99640979
12	notochord development (GO:0030903)	4.68151799
13	glomerulus development (GO:0032835)	4.67895278
14	regulation of female gonad development (GO:2000194)	4.64129535
15	diaphragm development (GO:0060539)	4.60881540
16	skeletal muscle organ development (GO:0060538)	4.60867464
17	mesenchymal to epithelial transition (GO:0060231)	4.60265624
18	protein targeting to Golgi (GO:0000042)	4.44940402
19	response to gonadotropin (GO:0034698)	4.43845025
20	fatty acid elongation (GO:0030497)	4.41226112
21	embryonic foregut morphogenesis (GO:0048617)	4.38062667
22	glomerular basement membrane development (GO:0032836)	4.28608297
23	establishment of protein localization to Golgi (GO:0072600)	4.26652914
24	cardiac right ventricle morphogenesis (GO:0003215)	4.24645773
25	kidney mesenchyme development (GO:0072074)	4.21122925
26	cardiac muscle hypertrophy in response to stress (GO:0014898)	4.20547425
27	muscle hypertrophy in response to stress (GO:0003299)	4.20547425
28	cardiac muscle adaptation (GO:0014887)	4.20547425
29	cellular response to follicle-stimulating hormone stimulus (GO:0071372)	4.17085473
30	male genitalia development (GO:0030539)	4.16445945
31	regulation of cardioblast differentiation (GO:0051890)	4.12601135
32	muscle cell fate commitment (GO:0042693)	4.07814914
33	regulation of mesenchymal cell apoptotic process (GO:2001053)	4.00344971
34	epithelial cell differentiation involved in kidney development (GO:0035850)	3.99714409
35	retrograde transport, vesicle recycling within Golgi (GO:0000301)	3.98933570
36	protein polyglutamylation (GO:0018095)	3.98709639
37	negative regulation of kidney development (GO:0090185)	3.98650066
38	mesonephros development (GO:0001823)	3.98605124
39	SMAD protein signal transduction (GO:0060395)	3.97476367
40	sperm motility (GO:0030317)	3.95279115
41	regulation of cell proliferation involved in kidney development (GO:1901722)	3.93322549
42	sex determination (GO:0007530)	3.86970412
43	centriole replication (GO:0007099)	3.82501314
44	endocardial cushion development (GO:0003197)	3.79370204
45	short-term memory (GO:0007614)	3.78121985
46	positive regulation of mesonephros development (GO:0061213)	3.73784468
47	protein localization to Golgi apparatus (GO:0034067)	3.70711998
48	regulation of glomerulus development (GO:0090192)	3.65654081
49	response to follicle-stimulating hormone (GO:0032354)	3.51855172
50	regulation of centriole replication (GO:0046599)	3.46127014
51	centriole assembly (GO:0098534)	3.42515210
52	reproductive system development (GO:0061458)	3.39373174
53	glucose 6-phosphate metabolic process (GO:0051156)	3.39367531
54	positive regulation of neurological system process (GO:0031646)	3.37612595
55	positive regulation of heart growth (GO:0060421)	3.33805224
56	protein carboxylation (GO:0018214)	3.31909188
57	peptidyl-glutamic acid carboxylation (GO:0017187)	3.31909188
58	galactose catabolic process (GO:0019388)	3.29017374
59	peptidyl-glutamic acid modification (GO:0018200)	3.26012409
60	cardiac muscle hypertrophy (GO:0003300)	3.23230472
61	ubiquinone biosynthetic process (GO:0006744)	3.19490644
62	single strand break repair (GO:0000012)	3.19169613
63	regulation of mesonephros development (GO:0061217)	3.17874434
64	regulation of transmission of nerve impulse (GO:0051969)	3.17058753
65	oxidative demethylation (GO:0070989)	3.11437416
66	ethanol oxidation (GO:0006069)	3.10510771
67	tyrosine metabolic process (GO:0006570)	3.07001578
68	nephron tubule formation (GO:0072079)	3.06534887
69	striated muscle hypertrophy (GO:0014897)	3.02405605
70	regulation of gonadotropin secretion (GO:0032276)	3.01530968
71	peroxisome fission (GO:0016559)	2.98915250
72	microtubule polymerization or depolymerization (GO:0031109)	2.98881588
73	cellular response to BMP stimulus (GO:0071773)	2.97993974
74	response to BMP (GO:0071772)	2.97993974
75	DNA demethylation (GO:0080111)	2.96486794
76	quinone biosynthetic process (GO:1901663)	2.93838661
77	negative regulation of catecholamine secretion (GO:0033604)	2.92723567
78	ubiquinone metabolic process (GO:0006743)	2.90185215
79	phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)	2.88564582
80	intestinal cholesterol absorption (GO:0030299)	2.86067037
81	galactose metabolic process (GO:0006012)	2.84566804
82	male gonad development (GO:0008584)	2.80777381
83	regulation of bile acid biosynthetic process (GO:0070857)	2.77123409
84	biotin metabolic process (GO:0006768)	2.76968798
85	spermatogenesis (GO:0007283)	2.76705188
86	male gamete generation (GO:0048232)	2.76315323
87	male sex determination (GO:0030238)	2.75359351
88	positive regulation of synapse maturation (GO:0090129)	2.75195291
89	alpha-linolenic acid metabolic process (GO:0036109)	2.74925368
90	metanephric epithelium development (GO:0072207)	2.73992872
91	placenta development (GO:0001890)	2.70331352
92	nuclear pore complex assembly (GO:0051292)	2.68857122
93	plasma lipoprotein particle assembly (GO:0034377)	2.66538130
94	microtubule depolymerization (GO:0007019)	2.66463800
95	anterior/posterior axis specification, embryo (GO:0008595)	2.65597753
96	positive regulation of guanylate cyclase activity (GO:0031284)	2.65126309
97	regulation of helicase activity (GO:0051095)	2.63534494
98	positive regulation of insulin receptor signaling pathway (GO:0046628)	2.62558295
99	negative regulation of fibrinolysis (GO:0051918)	2.60720634
100	regulation of chromatin binding (GO:0035561)	2.59483374

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	4.53486738
2	SALL1_21062744_ChIP-ChIP_HESCs_Human	4.01936910
3	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.81440088
4	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	3.42246422
5	IGF1R_20145208_ChIP-Seq_DFB_Human	2.55372638
6	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.41637043
7	ZNF274_21170338_ChIP-Seq_K562_Hela	2.32058552
8	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	2.26682467
9	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	2.24780402
10	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.99368782
11	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.95514825
12	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.84768804
13	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.84165921
14	FUS_26573619_Chip-Seq_HEK293_Human	1.82149987
15	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.75968186
16	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.71815578
17	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.69215008
18	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.68126362
19	CBP_20019798_ChIP-Seq_JUKART_Human	1.68126362
20	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.67811208
21	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.63299968
22	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.63299968
23	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.63269627
24	RNF2_27304074_Chip-Seq_NSC_Mouse	1.57828747
25	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.48858356
26	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.47794151
27	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.45055825
28	GBX2_23144817_ChIP-Seq_PC3_Human	1.44325709
29	FOXA2_19822575_ChIP-Seq_HepG2_Human	1.44180030
30	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.43823283
31	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.42934816
32	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.42901064
33	P300_19829295_ChIP-Seq_ESCs_Human	1.41157151
34	ZNF263_19887448_ChIP-Seq_K562_Human	1.39767474
35	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.38375629
36	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.37975993
37	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.36660030
38	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.35473718
39	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.33078916
40	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.32535453
41	TAF15_26573619_Chip-Seq_HEK293_Human	1.29937387
42	HNF4A_19822575_ChIP-Seq_HepG2_Human	1.27884012
43	IRF1_19129219_ChIP-ChIP_H3396_Human	1.27166250
44	NANOG_19829295_ChIP-Seq_ESCs_Human	1.26788074
45	SOX2_19829295_ChIP-Seq_ESCs_Human	1.26788074
46	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.24746957
47	NACC1_18358816_ChIP-ChIP_MESCs_Mouse	1.24250907
48	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.23460824
49	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.22963443
50	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.22922090
51	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.22615889
52	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.22615889
53	EWS_26573619_Chip-Seq_HEK293_Human	1.22010994
54	SALL4_18804426_ChIP-ChIP_XEN_Mouse	1.21429832
55	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.20869942
56	RXR_22158963_ChIP-Seq_LIVER_Mouse	1.18187478
57	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.16936264
58	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.15179472
59	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.13291412
60	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.12983405
61	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	1.12824750
62	SALL4_18804426_ChIP-ChIP_MESCs_Mouse	1.11057584
63	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.09057429
64	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.06978720
65	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.05885375
66	HTT_18923047_ChIP-ChIP_STHdh_Human	1.05174348
67	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.04772684
68	GATA4_25053715_ChIP-Seq_YYC3_Human	1.03953764
69	TCF3_18692474_ChIP-Seq_MESCs_Mouse	1.03700061
70	TP53_22573176_ChIP-Seq_HFKS_Human	1.03369686
71	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.03161852
72	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.02515190
73	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.01800999
74	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.01559418
75	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.00096861
76	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.99421244
77	FOXO3_23340844_ChIP-Seq_DLD1_Human	0.97264836
78	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.96123502
79	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.95926750
80	NCOR_22424771_ChIP-Seq_293T_Human	0.95066350
81	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.95033771
82	VDR_22108803_ChIP-Seq_LS180_Human	0.92065731
83	KDM2B_26808549_Chip-Seq_REH_Human	0.91914694
84	TCF4_23295773_ChIP-Seq_U87_Human	0.90733726
85	PPARA_22158963_ChIP-Seq_LIVER_Mouse	0.90529407
86	STAT3_23295773_ChIP-Seq_U87_Human	0.90265406
87	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	0.88887058
88	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	0.88868273
89	ZIC3_20872845_ChIP-ChIP_MESCs_Mouse	0.88781949
90	RUNX2_22187159_ChIP-Seq_PCA_Human	0.87826142
91	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.86051185
92	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.85755022
93	EOMES_21245162_ChIP-Seq_HESCs_Human	0.84879271
94	E2F1_17053090_ChIP-ChIP_MCF-7_Human	0.83884654
95	PKCTHETA_26484144_Chip-Seq_BREAST_Human	0.83644151
96	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	0.82640639
97	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.82137527
98	CDX2_22108803_ChIP-Seq_LS180_Human	0.81827767
99	RAC3_21632823_ChIP-Seq_H3396_Human	0.80208353
100	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.79852266

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	5.18363719
2	MP0008995_early_reproductive_senescence	4.94594379
3	MP0003195_calcinosis	4.61882062
4	MP0005410_abnormal_fertilization	3.52910055
5	MP0003828_pulmonary_edema	3.47722762
6	MP0003123_paternal_imprinting	3.20572955
7	MP0009384_cardiac_valve_regurgitation	3.07746973
8	MP0005423_abnormal_somatic_nervous	2.87015925
9	MP0000537_abnormal_urethra_morphology	2.83691378
10	MP0003567_abnormal_fetal_cardiomyocyte	2.57688833
11	MP0003315_abnormal_perineum_morphology	2.32690543
12	MP0000516_abnormal_urinary_system	2.24955308
13	MP0005367_renal/urinary_system_phenotyp	2.24955308
14	MP0003122_maternal_imprinting	2.07663681
15	MP0000639_abnormal_adrenal_gland	2.04757647
16	MP0003786_premature_aging	1.97568145
17	MP0003121_genomic_imprinting	1.94441576
18	MP0001764_abnormal_homeostasis	1.86222539
19	MP0001661_extended_life_span	1.82340806
20	MP0002638_abnormal_pupillary_reflex	1.75338050
21	MP0001919_abnormal_reproductive_system	1.74081146
22	MP0001929_abnormal_gametogenesis	1.59475168
23	MP0003011_delayed_dark_adaptation	1.54280651
24	MP0003698_abnormal_male_reproductive	1.51977202
25	MP0005220_abnormal_exocrine_pancreas	1.49261474
26	MP0002089_abnormal_postnatal_growth/wei	1.46019006
27	MP0002295_abnormal_pulmonary_circulatio	1.43463443
28	MP0002254_reproductive_system_inflammat	1.40726449
29	MP0005389_reproductive_system_phenotype	1.39413095
30	MP0001145_abnormal_male_reproductive	1.38516486
31	MP0003119_abnormal_digestive_system	1.35742717
32	MP0003115_abnormal_respiratory_system	1.32849820
33	MP0002102_abnormal_ear_morphology	1.31171420
34	MP0003878_abnormal_ear_physiology	1.30254799
35	MP0005377_hearing/vestibular/ear_phenot	1.30254799
36	MP0002229_neurodegeneration	1.27404198
37	MP0002210_abnormal_sex_determination	1.25288115
38	MP0003221_abnormal_cardiomyocyte_apopto	1.24944824
39	MP0000653_abnormal_sex_gland	1.23533601
40	MP0004957_abnormal_blastocyst_morpholog	1.14247351
41	MP0005365_abnormal_bile_salt	1.10960189
42	MP0002127_abnormal_cardiovascular_syste	1.10293776
43	MP0000749_muscle_degeneration	1.08343998
44	MP0005551_abnormal_eye_electrophysiolog	1.08340276
45	MP0001188_hyperpigmentation	1.07750744
46	MP0010368_abnormal_lymphatic_system	1.07382631
47	MP0003943_abnormal_hepatobiliary_system	1.07326257
48	MP0001666_abnormal_nutrient_absorption	1.06605600
49	MP0004085_abnormal_heartbeat	1.05231835
50	MP0006035_abnormal_mitochondrial_morpho	1.04796609
51	MP0009697_abnormal_copulation	1.03497144
52	MP0008260_abnormal_autophagy	1.02204814
53	MP0003942_abnormal_urinary_system	1.01396256
54	MP0002161_abnormal_fertility/fecundity	1.00932975
55	MP0001984_abnormal_olfaction	0.99848618
56	MP0005408_hypopigmentation	0.98060142
57	MP0006276_abnormal_autonomic_nervous	0.97974051
58	MP0000566_synostosis	0.95435367
59	MP0003718_maternal_effect	0.94832244
60	MP0010329_abnormal_lipoprotein_level	0.89480512
61	MP0006138_congestive_heart_failure	0.84520537
62	MP0005379_endocrine/exocrine_gland_phen	0.83634637
63	MP0004019_abnormal_vitamin_homeostasis	0.83605781
64	MP0003937_abnormal_limbs/digits/tail_de	0.83478446
65	MP0001529_abnormal_vocalization	0.82477245
66	MP0003936_abnormal_reproductive_system	0.81856783
67	MP0001727_abnormal_embryo_implantation	0.81615046
68	MP0003137_abnormal_impulse_conducting	0.80779506
69	MP0001915_intracranial_hemorrhage	0.79467197
70	MP0000372_irregular_coat_pigmentation	0.78546817
71	MP0005647_abnormal_sex_gland	0.76189915
72	MP0006036_abnormal_mitochondrial_physio	0.75469704
73	MP0002184_abnormal_innervation	0.74639099
74	MP0008875_abnormal_xenobiotic_pharmacok	0.74422555
75	MP0002938_white_spotting	0.74399142
76	MP0005332_abnormal_amino_acid	0.74043585
77	MP0005253_abnormal_eye_physiology	0.73660023
78	MP0005391_vision/eye_phenotype	0.72675559
79	MP0000467_abnormal_esophagus_morphology	0.71276855
80	MP0003787_abnormal_imprinting	0.70373677
81	MP0004043_abnormal_pH_regulation	0.70325385
82	MP0009672_abnormal_birth_weight	0.69532150
83	MP0003941_abnormal_skin_development	0.69125275
84	MP0001293_anophthalmia	0.68440144
85	MP0001119_abnormal_female_reproductive	0.67897882
86	MP0002084_abnormal_developmental_patter	0.67215486
87	MP0005085_abnormal_gallbladder_physiolo	0.67048676
88	MP0005670_abnormal_white_adipose	0.65669105
89	MP0008057_abnormal_DNA_replication	0.65375238
90	MP0001730_embryonic_growth_arrest	0.64500091
91	MP0003646_muscle_fatigue	0.63051658
92	MP0005646_abnormal_pituitary_gland	0.62475414
93	MP0004133_heterotaxia	0.61265830
94	MP0005451_abnormal_body_composition	0.60604927
95	MP0002092_abnormal_eye_morphology	0.60237810
96	MP0002909_abnormal_adrenal_gland	0.60112722
97	MP0002139_abnormal_hepatobiliary_system	0.59989602
98	MP0002822_catalepsy	0.59963834
99	MP0000631_abnormal_neuroendocrine_gland	0.59914257
100	MP0005395_other_phenotype	0.59728524

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Diaphragmatic weakness (HP:0009113)	6.61097950
2	Gonadal dysgenesis (HP:0000133)	6.54827141
3	Stridor (HP:0010307)	5.76080761
4	Dry hair (HP:0011359)	5.22307885
5	Testicular neoplasm (HP:0010788)	5.03806456
6	Degeneration of anterior horn cells (HP:0002398)	4.52835794
7	Abnormality of the anterior horn cell (HP:0006802)	4.52835794
8	Mesangial abnormality (HP:0001966)	4.41874056
9	Degeneration of the lateral corticospinal tracts (HP:0002314)	4.16534905
10	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	4.16534905
11	Hyperglycinemia (HP:0002154)	4.12172481
12	Spinal muscular atrophy (HP:0007269)	4.11076093
13	Hand muscle atrophy (HP:0009130)	4.05074052
14	Transposition of the great arteries (HP:0001669)	3.97980804
15	Abnormal connection of the cardiac segments (HP:0011545)	3.97980804
16	Abnormal ventriculo-arterial connection (HP:0011563)	3.97980804
17	Hypoplastic left heart (HP:0004383)	3.97711290
18	Tubulointerstitial nephritis (HP:0001970)	3.92786692
19	True hermaphroditism (HP:0010459)	3.82513770
20	Anomalous pulmonary venous return (HP:0010772)	3.76117838
21	Male infertility (HP:0003251)	3.75648137
22	Abnormality of the corticospinal tract (HP:0002492)	3.73344013
23	Tongue fasciculations (HP:0001308)	3.68139190
24	Facial diplegia (HP:0001349)	3.51622124
25	Male pseudohermaphroditism (HP:0000037)	3.49961111
26	Abnormality of the pulmonary veins (HP:0011718)	3.39158626
27	Hypoplastic heart (HP:0001961)	3.13575973
28	Muscle fibrillation (HP:0010546)	3.09523684
29	Hypoglycemic seizures (HP:0002173)	3.03729356
30	Abnormality of the vocal cords (HP:0008777)	2.96651129
31	Impaired vibration sensation in the lower limbs (HP:0002166)	2.96018639
32	Upper limb amyotrophy (HP:0009129)	2.94436091
33	Distal upper limb amyotrophy (HP:0007149)	2.94436091
34	Nephroblastoma (Wilms tumor) (HP:0002667)	2.93318043
35	Hypoglycemic coma (HP:0001325)	2.89040659
36	Atrophy/Degeneration involving motor neurons (HP:0007373)	2.88393761
37	Gonadotropin excess (HP:0000837)	2.84215307
38	Osteomalacia (HP:0002749)	2.82632664
39	Embryonal renal neoplasm (HP:0011794)	2.77523351
40	Focal segmental glomerulosclerosis (HP:0000097)	2.76398714
41	Menstrual irregularities (HP:0000858)	2.62001497
42	Hypoalphalipoproteinemia (HP:0003233)	2.59166636
43	Abnormal lung lobation (HP:0002101)	2.58929458
44	Hypoplastic pelvis (HP:0008839)	2.56771243
45	Hyperglycinuria (HP:0003108)	2.53231423
46	Glomerulosclerosis (HP:0000096)	2.46580469
47	Abnormality of the lower motor neuron (HP:0002366)	2.46211769
48	Abnormal sex determination (HP:0012244)	2.42020910
49	Sex reversal (HP:0012245)	2.42020910
50	Deep venous thrombosis (HP:0002625)	2.39976198
51	Hypolipoproteinemia (HP:0010981)	2.38346319
52	Urinary urgency (HP:0000012)	2.37965252
53	Clumsiness (HP:0002312)	2.33799679
54	Woolly hair (HP:0002224)	2.32631320
55	Abnormality of serine family amino acid metabolism (HP:0010894)	2.32039815
56	Abnormality of glycine metabolism (HP:0010895)	2.32039815
57	Irregular epiphyses (HP:0010582)	2.29745755
58	Arthropathy (HP:0003040)	2.29227040
59	Chronic hepatic failure (HP:0100626)	2.23842746
60	Abnormality of endocrine pancreas physiology (HP:0012093)	2.19701409
61	Abnormality of the pancreatic islet cells (HP:0006476)	2.19701409
62	Female pseudohermaphroditism (HP:0010458)	2.19493311
63	Tachypnea (HP:0002789)	2.16653061
64	Beaking of vertebral bodies (HP:0004568)	2.15203407
65	External ophthalmoplegia (HP:0000544)	2.13025627
66	Resting tremor (HP:0002322)	2.05389483
67	Ankle clonus (HP:0011448)	2.03490304
68	Abnormality of the peritoneum (HP:0002585)	2.01502276
69	Testicular atrophy (HP:0000029)	2.00208285
70	Urinary bladder sphincter dysfunction (HP:0002839)	1.98771098
71	Hypobetalipoproteinemia (HP:0003563)	1.95937522
72	Hypotrichosis (HP:0001006)	1.95599229
73	Small epiphyses (HP:0010585)	1.93879283
74	Hyperinsulinemic hypoglycemia (HP:0000825)	1.91806132
75	Weak cry (HP:0001612)	1.91106041
76	Primary adrenal insufficiency (HP:0008207)	1.90324099
77	Stage 5 chronic kidney disease (HP:0003774)	1.89276518
78	Bulbar palsy (HP:0001283)	1.84009675
79	Hypoventilation (HP:0002791)	1.81667058
80	Gout (HP:0001997)	1.81526934
81	Prolonged partial thromboplastin time (HP:0003645)	1.79422833
82	Neonatal short-limb short stature (HP:0008921)	1.77621738
83	Meckel diverticulum (HP:0002245)	1.76979286
84	Decreased lacrimation (HP:0000633)	1.76606967
85	Myopathic facies (HP:0002058)	1.72884333
86	Abnormal tarsal ossification (HP:0008369)	1.71870467
87	Flat acetabular roof (HP:0003180)	1.71820597
88	Abnormality of the ileum (HP:0001549)	1.71523805
89	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	1.69915481
90	Ovarian neoplasm (HP:0100615)	1.69158914
91	Periauricular skin pits (HP:0100277)	1.68865519
92	Preauricular pit (HP:0004467)	1.68865519
93	Infertility (HP:0000789)	1.68687231
94	Delayed CNS myelination (HP:0002188)	1.68190539
95	Abnormality of the motor neurons (HP:0002450)	1.68182122
96	Abnormal neuron morphology (HP:0012757)	1.68182122
97	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	1.68148154
98	Symptomatic seizures (HP:0011145)	1.66175565
99	Abnormality of the pupil (HP:0000615)	1.65907020
100	Impaired vibratory sensation (HP:0002495)	1.65112227

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	AKT3	5.84579764
2	PLK4	5.78285443
3	ACVR1B	3.70657285
4	INSRR	2.99999008
5	TRIM28	2.90064060
6	ERBB3	2.66618687
7	PBK	2.24647890
8	BRD4	2.16711728
9	WNK4	2.13004135
10	SRPK1	2.06524933
11	BRAF	1.99999396
12	EPHB1	1.98573065
13	PLK2	1.92551234
14	TYRO3	1.89680368
15	DYRK3	1.72148564
16	PAK3	1.42584710
17	LATS1	1.41090050
18	PKN2	1.39252656
19	PNCK	1.37472783
20	MAPKAPK5	1.35517239
21	SGK2	1.28938856
22	BCR	1.26732252
23	EPHA3	1.16164209
24	EPHA4	1.14490152
25	SGK223	1.11979217
26	SGK494	1.11979217
27	NEK2	1.11603282
28	PINK1	1.10177452
29	KSR2	1.09185462
30	MARK1	1.09150853
31	PLK3	1.05835678
32	FLT3	1.05379464
33	FGFR2	0.98768813
34	CDK12	0.97547447
35	BMPR1B	0.97491248
36	PLK1	0.96833322
37	SIK2	0.96677917
38	CDK7	0.93366839
39	BRSK1	0.89116705
40	LMTK2	0.87651073
41	PRKCG	0.86618135
42	MATK	0.85802553
43	STK38L	0.83915139
44	MKNK1	0.83885692
45	STK38	0.83856498
46	MKNK2	0.83188526
47	SGK3	0.82265090
48	PAK6	0.81733863
49	GRK1	0.80691721
50	TTK	0.80268466
51	FGFR4	0.80243086
52	FGFR1	0.77901809
53	NUAK1	0.77891403
54	WNK1	0.77628841
55	KSR1	0.71048557
56	BRSK2	0.69045368
57	MAP3K4	0.64284956
58	PDK1	0.63651387
59	WNK3	0.63434256
60	FGFR3	0.63402302
61	ALK	0.62302989
62	STK4	0.60896091
63	TIE1	0.57873309
64	PDK2	0.57717543
65	CDK4	0.57164028
66	PRKACG	0.55547905
67	ATM	0.54224145
68	PRKAA2	0.51627386
69	SGK1	0.50713520
70	ZAK	0.50375941
71	RIPK1	0.50264979
72	MYLK	0.50126029
73	DYRK2	0.49556980
74	PDPK1	0.47295634
75	TAOK2	0.46897720
76	PRKACA	0.46376054
77	RPS6KA2	0.45078644
78	RAF1	0.43001039
79	DYRK1A	0.41278033
80	PHKG1	0.40694167
81	PHKG2	0.40694167
82	CAMK1G	0.39773678
83	CDK1	0.37589315
84	NEK6	0.36943269
85	FRK	0.36055100
86	PRKDC	0.35591422
87	CDK2	0.35129801
88	STK39	0.35041879
89	CSNK1E	0.34583344
90	CHEK1	0.33570389
91	CDK19	0.32875607
92	RPS6KA3	0.32797950
93	PRKACB	0.32237458
94	DMPK	0.32124079
95	OBSCN	0.31440667
96	AURKA	0.30945683
97	RPS6KA1	0.30427893
98	PRKAA1	0.30279755
99	PIK3CA	0.29770997
100	DYRK1B	0.29592988

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	5.34614087
2	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	3.88536620
3	Fatty acid elongation_Homo sapiens_hsa00062	3.61110031
4	Vitamin digestion and absorption_Homo sapiens_hsa04977	3.38048954
5	Propanoate metabolism_Homo sapiens_hsa00640	3.13291146
6	Complement and coagulation cascades_Homo sapiens_hsa04610	2.29471635
7	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	2.27964978
8	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.25530995
9	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.21958182
10	Steroid biosynthesis_Homo sapiens_hsa00100	2.17877867
11	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.94109659
12	Fatty acid metabolism_Homo sapiens_hsa01212	1.89367268
13	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.76676849
14	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.71571749
15	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.65613193
16	Carbon metabolism_Homo sapiens_hsa01200	1.62936822
17	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.60257506
18	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.57957351
19	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.55561773
20	Pyruvate metabolism_Homo sapiens_hsa00620	1.54194860
21	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.51064875
22	Galactose metabolism_Homo sapiens_hsa00052	1.50944228
23	Non-homologous end-joining_Homo sapiens_hsa03450	1.50196500
24	Fatty acid degradation_Homo sapiens_hsa00071	1.48743899
25	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.47233329
26	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.46084486
27	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.35565693
28	Fat digestion and absorption_Homo sapiens_hsa04975	1.31492773
29	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.24651803
30	RNA transport_Homo sapiens_hsa03013	1.24531267
31	Nicotine addiction_Homo sapiens_hsa05033	1.23995661
32	Arginine biosynthesis_Homo sapiens_hsa00220	1.20257356
33	Arginine and proline metabolism_Homo sapiens_hsa00330	1.16679927
34	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.15853113
35	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.15020788
36	Butanoate metabolism_Homo sapiens_hsa00650	1.10031009
37	PPAR signaling pathway_Homo sapiens_hsa03320	1.09341149
38	Peroxisome_Homo sapiens_hsa04146	1.06065858
39	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.01222883
40	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.00220617
41	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.96935003
42	Phototransduction_Homo sapiens_hsa04744	0.93849106
43	Histidine metabolism_Homo sapiens_hsa00340	0.86282280
44	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.80267807
45	Tyrosine metabolism_Homo sapiens_hsa00350	0.80101413
46	Retinol metabolism_Homo sapiens_hsa00830	0.78185594
47	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.77854988
48	Nucleotide excision repair_Homo sapiens_hsa03420	0.76263965
49	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.72222491
50	mTOR signaling pathway_Homo sapiens_hsa04150	0.71909660
51	Phenylalanine metabolism_Homo sapiens_hsa00360	0.70967524
52	Base excision repair_Homo sapiens_hsa03410	0.68175193
53	Chemical carcinogenesis_Homo sapiens_hsa05204	0.66124850
54	Protein export_Homo sapiens_hsa03060	0.63465110
55	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.62785966
56	ABC transporters_Homo sapiens_hsa02010	0.62748425
57	Glutathione metabolism_Homo sapiens_hsa00480	0.62209232
58	RNA polymerase_Homo sapiens_hsa03020	0.62145652
59	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.61127974
60	Fanconi anemia pathway_Homo sapiens_hsa03460	0.60234673
61	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.59799429
62	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.59040007
63	Metabolic pathways_Homo sapiens_hsa01100	0.58642426
64	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.58383127
65	Olfactory transduction_Homo sapiens_hsa04740	0.54934339
66	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.54756919
67	beta-Alanine metabolism_Homo sapiens_hsa00410	0.54185558
68	Homologous recombination_Homo sapiens_hsa03440	0.52831733
69	Circadian rhythm_Homo sapiens_hsa04710	0.52399980
70	Mismatch repair_Homo sapiens_hsa03430	0.51939502
71	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.51817949
72	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.49417594
73	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.43794719
74	Cardiac muscle contraction_Homo sapiens_hsa04260	0.43119363
75	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.42961026
76	Selenocompound metabolism_Homo sapiens_hsa00450	0.41317979
77	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.40939078
78	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.40842322
79	Basal transcription factors_Homo sapiens_hsa03022	0.39943092
80	DNA replication_Homo sapiens_hsa03030	0.38734625
81	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.37999219
82	Melanoma_Homo sapiens_hsa05218	0.34851968
83	One carbon pool by folate_Homo sapiens_hsa00670	0.34299341
84	mRNA surveillance pathway_Homo sapiens_hsa03015	0.34197441
85	Glucagon signaling pathway_Homo sapiens_hsa04922	0.33439524
86	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.32800300
87	Wnt signaling pathway_Homo sapiens_hsa04310	0.31453950
88	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.31278026
89	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.30633442
90	Long-term depression_Homo sapiens_hsa04730	0.30068723
91	Taste transduction_Homo sapiens_hsa04742	0.29662866
92	Sphingolipid metabolism_Homo sapiens_hsa00600	0.28136396
93	Cocaine addiction_Homo sapiens_hsa05030	0.27106785
94	Thyroid cancer_Homo sapiens_hsa05216	0.26722324
95	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.24597673
96	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.24302854
97	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.23825662
98	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.23692799
99	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.23629806
100	Oocyte meiosis_Homo sapiens_hsa04114	0.22309263

VN1R48P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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