VN1R51P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of male gonad development (GO:2000020)6.61680548
2negative regulation of metanephros development (GO:0072217)5.85513750
3regulation of male gonad development (GO:2000018)5.40644038
4chaperone-mediated protein transport (GO:0072321)4.99315200
5chromatin remodeling at centromere (GO:0031055)4.96823990
6CENP-A containing nucleosome assembly (GO:0034080)4.77586631
7cellular response to gonadotropin stimulus (GO:0071371)4.72858200
8mesenchymal to epithelial transition (GO:0060231)4.44049667
9notochord development (GO:0030903)4.33474128
10establishment of integrated proviral latency (GO:0075713)4.23713482
11histone exchange (GO:0043486)4.09374826
12short-chain fatty acid metabolic process (GO:0046459)4.08968121
13IMP biosynthetic process (GO:0006188)4.00030550
14metanephric mesenchyme development (GO:0072075)3.98108309
15mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.91887934
16regulation of helicase activity (GO:0051095)3.91173049
17ubiquinone biosynthetic process (GO:0006744)3.85707713
18establishment of protein localization to mitochondrial membrane (GO:0090151)3.73146875
19peptidyl-histidine modification (GO:0018202)3.68121889
20negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.62780900
21mitotic metaphase plate congression (GO:0007080)3.61707939
22cardiac right ventricle morphogenesis (GO:0003215)3.60825439
23purine nucleobase biosynthetic process (GO:0009113)3.60354237
24DNA replication-independent nucleosome assembly (GO:0006336)3.56296580
25DNA replication-independent nucleosome organization (GO:0034724)3.56296580
26diaphragm development (GO:0060539)3.54306284
27anterior/posterior axis specification, embryo (GO:0008595)3.53751595
28protein-chromophore linkage (GO:0018298)3.51289671
29muscle cell fate commitment (GO:0042693)3.50470686
30ubiquinone metabolic process (GO:0006743)3.49813532
31skeletal muscle organ development (GO:0060538)3.47114598
32pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.46938008
33negative regulation of DNA-dependent DNA replication (GO:2000104)3.46790494
34regulation of cell proliferation involved in kidney development (GO:1901722)3.44784455
35glomerulus development (GO:0032835)3.44386033
36cardiac muscle hypertrophy in response to stress (GO:0014898)3.43871976
37muscle hypertrophy in response to stress (GO:0003299)3.43871976
38cardiac muscle adaptation (GO:0014887)3.43871976
39proteasome assembly (GO:0043248)3.43136189
40male genitalia development (GO:0030539)3.39288552
41base-excision repair, AP site formation (GO:0006285)3.39125706
42DNA damage response, detection of DNA damage (GO:0042769)3.32364781
43regulation of cardioblast differentiation (GO:0051890)3.31175386
44kidney mesenchyme development (GO:0072074)3.30655133
45regulation of gene silencing by RNA (GO:0060966)3.30111270
46regulation of posttranscriptional gene silencing (GO:0060147)3.30111270
47regulation of gene silencing by miRNA (GO:0060964)3.30111270
48pseudouridine synthesis (GO:0001522)3.26530996
49IMP metabolic process (GO:0046040)3.24654100
50negative regulation of telomerase activity (GO:0051974)3.23431838
51DNA demethylation (GO:0080111)3.20473830
52fusion of sperm to egg plasma membrane (GO:0007342)3.17530350
53positive regulation of heart growth (GO:0060421)3.14646775
54response to gonadotropin (GO:0034698)3.13756881
55regulation of female gonad development (GO:2000194)3.11318985
56termination of RNA polymerase III transcription (GO:0006386)3.10691130
57transcription elongation from RNA polymerase III promoter (GO:0006385)3.10691130
58nucleobase biosynthetic process (GO:0046112)3.10392495
59establishment of viral latency (GO:0019043)3.08652431
60quinone biosynthetic process (GO:1901663)3.08393258
61regulation of mitochondrial translation (GO:0070129)3.07765523
62negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.05837592
63regulation of meiosis I (GO:0060631)3.05190760
64protein targeting to mitochondrion (GO:0006626)3.05034951
65rRNA modification (GO:0000154)3.03405559
66somatic diversification of immune receptors via somatic mutation (GO:0002566)3.02390223
67somatic hypermutation of immunoglobulin genes (GO:0016446)3.02390223
68epithelial cell differentiation involved in kidney development (GO:0035850)3.02091283
69energy coupled proton transport, down electrochemical gradient (GO:0015985)2.96540719
70ATP synthesis coupled proton transport (GO:0015986)2.96540719
71embryonic foregut morphogenesis (GO:0048617)2.94695932
72fatty acid elongation (GO:0030497)2.93968259
73mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.93941744
74regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.93662041
75regulation of glomerulus development (GO:0090192)2.93237589
76cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.92275350
77DNA double-strand break processing (GO:0000729)2.92047881
78female gonad development (GO:0008585)2.90476786
79negative regulation of mitotic sister chromatid separation (GO:2000816)2.89646105
80negative regulation of sister chromatid segregation (GO:0033046)2.89646105
81negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.89646105
82negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.89646105
83negative regulation of mitotic sister chromatid segregation (GO:0033048)2.89646105
84ribosomal small subunit assembly (GO:0000028)2.89346438
85exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.89049455
86regulation of chromatin binding (GO:0035561)2.88714203
87metaphase plate congression (GO:0051310)2.88491412
88cullin deneddylation (GO:0010388)2.85809730
89reproductive system development (GO:0061458)2.85535614
90SMAD protein signal transduction (GO:0060395)2.85265381
91pyrimidine nucleotide catabolic process (GO:0006244)2.83936806
92cellular protein complex localization (GO:0034629)2.83882849
93regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.83112967
94regulation of mitotic spindle checkpoint (GO:1903504)2.83112967
95negative regulation of kidney development (GO:0090185)2.82678164
96negative regulation of chromosome segregation (GO:0051985)2.82365094
97nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.81825253
98negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.80391808
99negative regulation of ligase activity (GO:0051352)2.80391808
100DNA replication checkpoint (GO:0000076)2.79947038

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.03683947
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.84008682
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.83514066
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.76967710
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.28832802
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.25333511
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.17107004
8CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.10894270
9CREB1_15753290_ChIP-ChIP_HEK293T_Human2.89500587
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.87867712
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.63863680
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.60619531
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.56059906
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.53781935
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.53139363
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.44756283
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.42228967
18MYC_18358816_ChIP-ChIP_MESCs_Mouse2.32666145
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.29484694
20POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.21007120
21EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.15183958
22HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.09389340
23KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.05791424
24KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.05791424
25KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.05791424
26FOXP3_21729870_ChIP-Seq_TREG_Human1.97473222
27NELFA_20434984_ChIP-Seq_ESCs_Mouse1.92604265
28E2F1_18555785_ChIP-Seq_MESCs_Mouse1.91382882
29ELK1_19687146_ChIP-ChIP_HELA_Human1.87403733
30PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.87352793
31THAP11_20581084_ChIP-Seq_MESCs_Mouse1.86883972
32POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.83964392
33VDR_23849224_ChIP-Seq_CD4+_Human1.83465268
34POU5F1_16153702_ChIP-ChIP_HESCs_Human1.80408761
35PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.77938614
36HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.76873066
37TCF3_18692474_ChIP-Seq_MEFs_Mouse1.72828497
38POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.71691104
39NANOG_16153702_ChIP-ChIP_HESCs_Human1.69683973
40KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.67508096
41DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.67254129
42FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.66951490
43YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.66422683
44NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.64567614
45MYCN_18555785_ChIP-Seq_MESCs_Mouse1.62726253
46DCP1A_22483619_ChIP-Seq_HELA_Human1.60864467
47E2F1_21310950_ChIP-Seq_MCF-7_Human1.57947150
48MYC_18940864_ChIP-ChIP_HL60_Human1.53733128
49SRF_21415370_ChIP-Seq_HL-1_Mouse1.52902375
50CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.51655995
51PADI4_21655091_ChIP-ChIP_MCF-7_Human1.50696204
52MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.48587617
53SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.44425353
54XRN2_22483619_ChIP-Seq_HELA_Human1.42439017
55TTF2_22483619_ChIP-Seq_HELA_Human1.42396505
56ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.40231475
57VDR_22108803_ChIP-Seq_LS180_Human1.39875602
58NANOG_18555785_ChIP-Seq_MESCs_Mouse1.39386559
59TCF3_18692474_ChIP-Seq_MESCs_Mouse1.38329209
60EWS_26573619_Chip-Seq_HEK293_Human1.37844648
61ZNF274_21170338_ChIP-Seq_K562_Hela1.37675523
62GABP_19822575_ChIP-Seq_HepG2_Human1.35973814
63NOTCH1_21737748_ChIP-Seq_TLL_Human1.34278819
64HOXB4_20404135_ChIP-ChIP_EML_Mouse1.31226189
65FOXM1_23109430_ChIP-Seq_U2OS_Human1.29501560
66ZNF263_19887448_ChIP-Seq_K562_Human1.29448713
67GATA1_26923725_Chip-Seq_HPCs_Mouse1.29061630
68SOX2_16153702_ChIP-ChIP_HESCs_Human1.29039564
69AR_21909140_ChIP-Seq_LNCAP_Human1.27284266
70YY1_21170310_ChIP-Seq_MESCs_Mouse1.27113740
71FLI1_27457419_Chip-Seq_LIVER_Mouse1.26902347
72NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.21728223
73CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.20331671
74ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.20289372
75E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.16587909
76ZFX_18555785_ChIP-Seq_MESCs_Mouse1.16300508
77ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.16229981
78GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.13347670
79STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.07333752
80PCGF2_27294783_Chip-Seq_ESCs_Mouse1.06536350
81NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.04160785
82TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03642233
83PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.00645906
84SOX2_18555785_ChIP-Seq_MESCs_Mouse0.99964786
85IGF1R_20145208_ChIP-Seq_DFB_Human0.97450727
86SOX2_18692474_ChIP-Seq_MEFs_Mouse0.95232360
87HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.93927749
88SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.92782889
89HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.92593918
90KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.92332720
91SOX17_20123909_ChIP-Seq_XEN_Mouse0.91148625
92GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.87250204
93FUS_26573619_Chip-Seq_HEK293_Human0.85741972
94GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84727052
95FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.84016064
96NANOG_18692474_ChIP-Seq_MEFs_Mouse0.82859353
97NANOG_21062744_ChIP-ChIP_HESCs_Human0.81842648
98SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.81298932
99CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.71935721
100PCGF2_27294783_Chip-Seq_NPCs_Mouse0.71802334

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008995_early_reproductive_senescence5.18085800
2MP0008877_abnormal_DNA_methylation4.57067393
3MP0003941_abnormal_skin_development3.54950022
4MP0000537_abnormal_urethra_morphology3.38321595
5MP0003123_paternal_imprinting3.34698541
6MP0004957_abnormal_blastocyst_morpholog3.16597738
7MP0003786_premature_aging2.95524083
8MP0003315_abnormal_perineum_morphology2.79703921
9MP0003195_calcinosis2.78850977
10MP0002254_reproductive_system_inflammat2.72846138
11MP0001188_hyperpigmentation2.69750798
12MP0003567_abnormal_fetal_cardiomyocyte2.58780191
13MP0003693_abnormal_embryo_hatching2.56245622
14MP0008058_abnormal_DNA_repair2.53425580
15MP0003828_pulmonary_edema2.40523259
16MP0003111_abnormal_nucleus_morphology2.37872594
17MP0009384_cardiac_valve_regurgitation2.19996753
18MP0010094_abnormal_chromosome_stability2.15593770
19MP0003718_maternal_effect1.95351801
20MP0005367_renal/urinary_system_phenotyp1.95280634
21MP0000516_abnormal_urinary_system1.95280634
22MP0001919_abnormal_reproductive_system1.89360261
23MP0008057_abnormal_DNA_replication1.88374907
24MP0003121_genomic_imprinting1.85086804
25MP0005423_abnormal_somatic_nervous1.75159023
26MP0003119_abnormal_digestive_system1.73437240
27MP0008932_abnormal_embryonic_tissue1.71850605
28MP0009672_abnormal_birth_weight1.66279544
29MP0006036_abnormal_mitochondrial_physio1.58016919
30MP0003077_abnormal_cell_cycle1.52684501
31MP0000639_abnormal_adrenal_gland1.52227974
32MP0008007_abnormal_cellular_replicative1.48766413
33MP0001293_anophthalmia1.48458365
34MP0001764_abnormal_homeostasis1.47590661
35MP0005389_reproductive_system_phenotype1.45255639
36MP0003186_abnormal_redox_activity1.42825603
37MP0001145_abnormal_male_reproductive1.41669091
38MP0005410_abnormal_fertilization1.40833630
39MP0001661_extended_life_span1.35354565
40MP0002210_abnormal_sex_determination1.30773294
41MP0001730_embryonic_growth_arrest1.28605904
42MP0006035_abnormal_mitochondrial_morpho1.26857921
43MP0003890_abnormal_embryonic-extraembry1.26559931
44MP0000653_abnormal_sex_gland1.23654634
45MP0001929_abnormal_gametogenesis1.19293803
46MP0003011_delayed_dark_adaptation1.18801970
47MP0002084_abnormal_developmental_patter1.17988413
48MP0004133_heterotaxia1.17538008
49MP0003936_abnormal_reproductive_system1.14430038
50MP0006292_abnormal_olfactory_placode1.12005527
51MP0001119_abnormal_female_reproductive1.10357423
52MP0001727_abnormal_embryo_implantation1.10086899
53MP0001697_abnormal_embryo_size1.07422716
54MP0000467_abnormal_esophagus_morphology1.06379594
55MP0009333_abnormal_splenocyte_physiolog1.06343149
56MP0003787_abnormal_imprinting1.05591216
57MP0000749_muscle_degeneration1.03070307
58MP0010030_abnormal_orbit_morphology1.02934631
59MP0005220_abnormal_exocrine_pancreas1.01647407
60MP0002085_abnormal_embryonic_tissue1.01305107
61MP0002295_abnormal_pulmonary_circulatio0.98764078
62MP0002089_abnormal_postnatal_growth/wei0.95276747
63MP0009703_decreased_birth_body0.91098206
64MP0003937_abnormal_limbs/digits/tail_de0.90868423
65MP0003698_abnormal_male_reproductive0.90804169
66MP0005647_abnormal_sex_gland0.90410152
67MP0003137_abnormal_impulse_conducting0.89449868
68MP0004019_abnormal_vitamin_homeostasis0.87956849
69MP0000350_abnormal_cell_proliferation0.87939592
70MP0003942_abnormal_urinary_system0.87204630
71MP0003115_abnormal_respiratory_system0.85941455
72MP0002697_abnormal_eye_size0.85743575
73MP0009379_abnormal_foot_pigmentation0.85146925
74MP0002736_abnormal_nociception_after0.83805052
75MP0005380_embryogenesis_phenotype0.83790080
76MP0001672_abnormal_embryogenesis/_devel0.83790080
77MP0003943_abnormal_hepatobiliary_system0.80087651
78MP0002102_abnormal_ear_morphology0.79794361
79MP0008260_abnormal_autophagy0.78333556
80MP0000313_abnormal_cell_death0.77715640
81MP0002638_abnormal_pupillary_reflex0.76833334
82MP0000049_abnormal_middle_ear0.74522295
83MP0002160_abnormal_reproductive_system0.74306547
84MP0001984_abnormal_olfaction0.72909320
85MP0002938_white_spotting0.72617564
86MP0002111_abnormal_tail_morphology0.69977868
87MP0002080_prenatal_lethality0.68626996
88MP0005395_other_phenotype0.68267299
89MP0002086_abnormal_extraembryonic_tissu0.64057390
90MP0002229_neurodegeneration0.63965297
91MP0003699_abnormal_female_reproductive0.63832681
92MP0002161_abnormal_fertility/fecundity0.63763743
93MP0000631_abnormal_neuroendocrine_gland0.63616624
94MP0003984_embryonic_growth_retardation0.62259744
95MP0002088_abnormal_embryonic_growth/wei0.62122276
96MP0001177_atelectasis0.61985315
97MP0004197_abnormal_fetal_growth/weight/0.61059351
98MP0001286_abnormal_eye_development0.60169686
99MP0001485_abnormal_pinna_reflex0.57764076
100MP0008872_abnormal_physiological_respon0.57589239

Predicted human phenotypes

RankGene SetZ-score
1Diaphragmatic weakness (HP:0009113)6.53325832
2Gonadal dysgenesis (HP:0000133)6.11429426
3Dry hair (HP:0011359)5.64295586
4Stridor (HP:0010307)5.13768852
5Hyperglycinemia (HP:0002154)4.81764450
6Degeneration of anterior horn cells (HP:0002398)4.33773454
7Abnormality of the anterior horn cell (HP:0006802)4.33773454
8Hypoplastic left heart (HP:0004383)4.09106027
9Testicular neoplasm (HP:0010788)3.92061134
10Anomalous pulmonary venous return (HP:0010772)3.90660513
11Facial diplegia (HP:0001349)3.89096478
12Mesangial abnormality (HP:0001966)3.77740064
13Abnormal lung lobation (HP:0002101)3.76315401
14Male pseudohermaphroditism (HP:0000037)3.74568664
15Degeneration of the lateral corticospinal tracts (HP:0002314)3.69383059
16Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.69383059
17Transposition of the great arteries (HP:0001669)3.59253597
18Abnormal connection of the cardiac segments (HP:0011545)3.59253597
19Abnormal ventriculo-arterial connection (HP:0011563)3.59253597
20Abnormality of the pulmonary veins (HP:0011718)3.51880428
21True hermaphroditism (HP:0010459)3.49341535
22Tongue fasciculations (HP:0001308)3.46020772
23Nephroblastoma (Wilms tumor) (HP:0002667)3.45215282
24Abnormality of the vocal cords (HP:0008777)3.37348528
25Hand muscle atrophy (HP:0009130)3.36620873
26Embryonal renal neoplasm (HP:0011794)3.26394565
27Hyperglycinuria (HP:0003108)3.26292770
28Hypoplastic heart (HP:0001961)3.19177083
29Abnormality of serine family amino acid metabolism (HP:0010894)3.05261379
30Abnormality of glycine metabolism (HP:0010895)3.05261379
31Abnormality of the labia minora (HP:0012880)3.05144150
32Clumsiness (HP:0002312)2.96376188
33Muscle fibrillation (HP:0010546)2.95528918
34Spinal muscular atrophy (HP:0007269)2.95458857
35Acute encephalopathy (HP:0006846)2.91756335
36Gonadotropin excess (HP:0000837)2.88641480
37Abnormality of the corticospinal tract (HP:0002492)2.84667320
38Hypoplastic pelvis (HP:0008839)2.78793040
39Male infertility (HP:0003251)2.73174278
40Testicular atrophy (HP:0000029)2.67350430
41Osteomalacia (HP:0002749)2.62694252
42Atrophy/Degeneration involving motor neurons (HP:0007373)2.61108902
43Impaired vibration sensation in the lower limbs (HP:0002166)2.60779624
44Female pseudohermaphroditism (HP:0010458)2.59726514
45Abnormality of serum amino acid levels (HP:0003112)2.58004048
46Methylmalonic acidemia (HP:0002912)2.39294292
47Distal upper limb amyotrophy (HP:0007149)2.36094886
48Upper limb amyotrophy (HP:0009129)2.36094886
49Gout (HP:0001997)2.35129189
50Ovarian neoplasm (HP:0100615)2.29482454
51Tachypnea (HP:0002789)2.25398263
52Multiple enchondromatosis (HP:0005701)2.24517562
53Woolly hair (HP:0002224)2.24410067
54Increased hepatocellular lipid droplets (HP:0006565)2.24042639
55External ophthalmoplegia (HP:0000544)2.23723867
56Meckel diverticulum (HP:0002245)2.13874838
57Acute necrotizing encephalopathy (HP:0006965)2.10060983
58Abnormal number of erythroid precursors (HP:0012131)2.06184880
59Lipid accumulation in hepatocytes (HP:0006561)2.04542429
60Abnormality of the ileum (HP:0001549)2.02782942
61Abnormality of the lower motor neuron (HP:0002366)2.00521462
62Primary adrenal insufficiency (HP:0008207)1.98156734
63Megaloblastic anemia (HP:0001889)1.95795877
64Abnormal sex determination (HP:0012244)1.93786089
65Sex reversal (HP:0012245)1.93786089
66Colon cancer (HP:0003003)1.93136674
67Nausea (HP:0002018)1.91583407
68Renal Fanconi syndrome (HP:0001994)1.91510399
69Weak cry (HP:0001612)1.86320713
70Bulbar palsy (HP:0001283)1.85782903
71Embryonal neoplasm (HP:0002898)1.85755583
72Birth length less than 3rd percentile (HP:0003561)1.85170550
73Hypoventilation (HP:0002791)1.84225768
74Methylmalonic aciduria (HP:0012120)1.81816959
75Carpal bone hypoplasia (HP:0001498)1.80258914
76Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.78988791
77Bilateral microphthalmos (HP:0007633)1.78571442
78Abnormality of cells of the erythroid lineage (HP:0012130)1.78212850
79Cerebral edema (HP:0002181)1.76916629
80Beaking of vertebral bodies (HP:0004568)1.74755698
81Shoulder girdle muscle weakness (HP:0003547)1.74055238
82Increased CSF lactate (HP:0002490)1.73275323
83Abnormality of renal resorption (HP:0011038)1.72337145
84Myopathic facies (HP:0002058)1.71862384
85Abnormal mitochondria in muscle tissue (HP:0008316)1.71136951
86Mitochondrial inheritance (HP:0001427)1.68960228
87Ankle clonus (HP:0011448)1.68759620
88Primary amenorrhea (HP:0000786)1.68654443
89Abnormality of the vitamin B12 metabolism (HP:0004341)1.67936439
90Abnormality of methionine metabolism (HP:0010901)1.67359845
91Progressive macrocephaly (HP:0004481)1.63761394
92Urinary bladder sphincter dysfunction (HP:0002839)1.62557152
93Impaired vibratory sensation (HP:0002495)1.62348249
94Bifid tongue (HP:0010297)1.61560342
95Aplasia/Hypoplasia of the uvula (HP:0010293)1.61440639
96Ependymoma (HP:0002888)1.61353601
97Microvesicular hepatic steatosis (HP:0001414)1.60559238
98Neonatal short-limb short stature (HP:0008921)1.60060677
99Abnormality of chromosome stability (HP:0003220)1.59463826
100Macrocytic anemia (HP:0001972)1.58814243

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK4.22024101
2VRK23.95087651
3ACVR1B3.84834922
4BUB13.44780717
5CDC73.33527008
6TTK3.10604923
7SRPK12.56596101
8ZAK2.51665744
9MKNK22.51560466
10MKNK12.35476446
11MST42.33341046
12AKT32.25983856
13TAF12.20064421
14PLK32.17035986
15CDK192.12076765
16TNIK2.08930962
17EIF2AK32.04924145
18PLK41.92664172
19NME11.85216960
20NUAK11.83563225
21PDK21.76930823
22PLK11.75512964
23STK161.75009635
24VRK11.65453234
25TSSK61.56290203
26STK41.47820014
27WNK31.35152460
28NME21.29888245
29DYRK21.29505028
30TRIM281.24101268
31BRAF1.23600757
32DYRK31.18933790
33EIF2AK11.17925063
34STK38L1.17090199
35TAOK21.15730145
36WEE11.09287100
37ATR1.07109839
38ALK1.05694760
39CDK40.97754686
40BRSK20.96421933
41GRK10.94038766
42CHEK20.92289856
43ERBB30.91775794
44BMPR1B0.85519350
45AURKA0.82569119
46PRPF4B0.80519517
47CDK70.79950960
48ATM0.77321519
49CHEK10.74659299
50OXSR10.74503701
51AURKB0.72516147
52CSNK1G10.71880838
53INSRR0.61794448
54PAK30.61591594
55CSNK2A10.60382828
56PRKCG0.58796648
57TNK20.58352147
58EIF2AK20.57846583
59CSNK1G20.57044425
60PNCK0.56856459
61CSNK2A20.55601310
62PASK0.54445170
63PRKDC0.53573125
64BRSK10.52810963
65PAK40.49785936
66PHKG20.46441557
67PHKG10.46441557
68MYLK0.45835400
69LMTK20.43378432
70CDK90.42857785
71DAPK10.42103387
72CSNK1E0.41435539
73MAP3K120.40494711
74FGFR10.40300207
75PIM10.38648302
76CDK30.38489038
77CDK20.38477576
78ABL20.38434649
79STK240.38348941
80CSNK1G30.37707443
81CDK10.36937640
82PAK10.36642418
83RPS6KC10.36224094
84RPS6KL10.36224094
85MELK0.35598217
86NEK20.35361694
87RPS6KA60.34646354
88RPS6KA50.34285307
89MAP4K20.34210793
90CLK10.34086370
91MAPKAPK50.33761261
92NEK10.33200275
93RPS6KA10.32676056
94PAK60.29298004
95STK30.29072945
96CSNK1A10.28380899
97PRKACB0.28089825
98RAF10.27699091
99PRKACA0.27561782
100PRKCE0.26426027

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.22217981
2Mismatch repair_Homo sapiens_hsa034303.04329391
3Propanoate metabolism_Homo sapiens_hsa006403.02795306
4Fatty acid elongation_Homo sapiens_hsa000623.01359694
5DNA replication_Homo sapiens_hsa030302.93785725
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.69454972
7RNA polymerase_Homo sapiens_hsa030202.63752244
8Ribosome_Homo sapiens_hsa030102.52226159
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.47093724
10Vitamin digestion and absorption_Homo sapiens_hsa049772.32138539
11Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.24408711
12Homologous recombination_Homo sapiens_hsa034402.20550627
13Oxidative phosphorylation_Homo sapiens_hsa001902.19286535
14Base excision repair_Homo sapiens_hsa034102.14768848
15Pyruvate metabolism_Homo sapiens_hsa006202.11573995
16Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.05353058
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.02056056
18RNA transport_Homo sapiens_hsa030131.99273923
19Parkinsons disease_Homo sapiens_hsa050121.92887755
20Spliceosome_Homo sapiens_hsa030401.88938927
21Non-homologous end-joining_Homo sapiens_hsa034501.86482237
22Nucleotide excision repair_Homo sapiens_hsa034201.85619958
23Protein export_Homo sapiens_hsa030601.78371374
24One carbon pool by folate_Homo sapiens_hsa006701.77606754
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.72454654
26Vitamin B6 metabolism_Homo sapiens_hsa007501.72262818
27Basal transcription factors_Homo sapiens_hsa030221.69779565
28Huntingtons disease_Homo sapiens_hsa050161.63310475
29RNA degradation_Homo sapiens_hsa030181.57504258
30Glutathione metabolism_Homo sapiens_hsa004801.51512834
31Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.50161868
32Fanconi anemia pathway_Homo sapiens_hsa034601.49051865
33Carbon metabolism_Homo sapiens_hsa012001.44279517
34Cell cycle_Homo sapiens_hsa041101.43809600
35Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.37883686
36Primary bile acid biosynthesis_Homo sapiens_hsa001201.37635856
37Steroid biosynthesis_Homo sapiens_hsa001001.33835948
38Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.32428622
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.30549900
40Pyrimidine metabolism_Homo sapiens_hsa002401.27975686
41Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.27254919
42Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.22464879
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.17845958
442-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.17029117
45Purine metabolism_Homo sapiens_hsa002301.11364183
46Butanoate metabolism_Homo sapiens_hsa006501.10334287
47Peroxisome_Homo sapiens_hsa041461.05883392
48Alzheimers disease_Homo sapiens_hsa050100.98696525
49mRNA surveillance pathway_Homo sapiens_hsa030150.94642713
50Fatty acid metabolism_Homo sapiens_hsa012120.93263074
51Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.79675804
52Arginine and proline metabolism_Homo sapiens_hsa003300.78673943
53beta-Alanine metabolism_Homo sapiens_hsa004100.77582350
54Fatty acid degradation_Homo sapiens_hsa000710.77231385
55Metabolic pathways_Homo sapiens_hsa011000.76513714
56Selenocompound metabolism_Homo sapiens_hsa004500.75272498
57Cardiac muscle contraction_Homo sapiens_hsa042600.74714942
58Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.73229465
59Pentose and glucuronate interconversions_Homo sapiens_hsa000400.71303766
60Oocyte meiosis_Homo sapiens_hsa041140.67781678
61Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.66786204
62Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.64751724
63Biosynthesis of amino acids_Homo sapiens_hsa012300.64573845
64TGF-beta signaling pathway_Homo sapiens_hsa043500.60645401
65Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.60602372
66Galactose metabolism_Homo sapiens_hsa000520.58461432
67Cyanoamino acid metabolism_Homo sapiens_hsa004600.52845792
68Chemical carcinogenesis_Homo sapiens_hsa052040.52160124
69Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49236126
70Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48587515
71Retinol metabolism_Homo sapiens_hsa008300.47424082
72Caffeine metabolism_Homo sapiens_hsa002320.46985933
73Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44551187
74p53 signaling pathway_Homo sapiens_hsa041150.43169672
75Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42134731
76Steroid hormone biosynthesis_Homo sapiens_hsa001400.41762782
77Hedgehog signaling pathway_Homo sapiens_hsa043400.41173127
78Phototransduction_Homo sapiens_hsa047440.41005504
79Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.40788249
80Wnt signaling pathway_Homo sapiens_hsa043100.40676063
81Thyroid cancer_Homo sapiens_hsa052160.39973061
82Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.38915005
83Pentose phosphate pathway_Homo sapiens_hsa000300.38114547
84Folate biosynthesis_Homo sapiens_hsa007900.36014388
85Drug metabolism - other enzymes_Homo sapiens_hsa009830.34107230
86Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.33434390
87Arginine biosynthesis_Homo sapiens_hsa002200.28398383
88Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.27358963
89Basal cell carcinoma_Homo sapiens_hsa052170.27226812
90Circadian rhythm_Homo sapiens_hsa047100.27068342
91Fat digestion and absorption_Homo sapiens_hsa049750.26814018
92Melanoma_Homo sapiens_hsa052180.26399669
93Sulfur metabolism_Homo sapiens_hsa009200.23914715
94Histidine metabolism_Homo sapiens_hsa003400.23302576
95Starch and sucrose metabolism_Homo sapiens_hsa005000.23251866
96Nicotine addiction_Homo sapiens_hsa050330.22764471
97PPAR signaling pathway_Homo sapiens_hsa033200.19611792
98Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.19502766
99Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.19259892
100Tight junction_Homo sapiens_hsa045300.17163513

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