ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	neurotransmitter-gated ion channel clustering (GO:0072578)	7.07248638
2	pyrimidine nucleobase catabolic process (GO:0006208)	6.94184608
3	neural tube formation (GO:0001841)	6.04266876
4	regulation of collateral sprouting (GO:0048670)	5.57250543
5	nucleobase catabolic process (GO:0046113)	5.49766153
6	central nervous system projection neuron axonogenesis (GO:0021952)	5.49193403
7	olfactory bulb development (GO:0021772)	4.84479710
8	central nervous system neuron axonogenesis (GO:0021955)	4.75676498
9	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	4.62415554
10	limb bud formation (GO:0060174)	4.52374449
11	glial cell proliferation (GO:0014009)	4.52047491
12	auditory behavior (GO:0031223)	4.47706998
13	negative regulation of dendrite development (GO:2000171)	4.30891012
14	behavioral response to nicotine (GO:0035095)	4.30530920
15	axonal fasciculation (GO:0007413)	4.20001647
16	presynaptic membrane assembly (GO:0097105)	4.04290321
17	neuron recognition (GO:0008038)	3.98462554
18	regulation of development, heterochronic (GO:0040034)	3.91862217
19	retinal ganglion cell axon guidance (GO:0031290)	3.91374548
20	presynaptic membrane organization (GO:0097090)	3.90647962
21	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	3.87757828
22	mechanosensory behavior (GO:0007638)	3.85094571
23	transmission of nerve impulse (GO:0019226)	3.81833879
24	sympathetic nervous system development (GO:0048485)	3.78796119
25	regulation of timing of cell differentiation (GO:0048505)	3.77310109
26	vocalization behavior (GO:0071625)	3.75658111
27	spinal cord development (GO:0021510)	3.71011038
28	somite development (GO:0061053)	3.63831563
29	cornea development in camera-type eye (GO:0061303)	3.58746627
30	negative regulation of transcription regulatory region DNA binding (GO:2000678)	3.58715252
31	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	3.55646179
32	retinal cone cell development (GO:0046549)	3.47236225
33	postsynaptic membrane organization (GO:0001941)	3.44477828
34	dendrite development (GO:0016358)	3.42061244
35	protein localization to synapse (GO:0035418)	3.39459169
36	positive regulation of mitochondrial fission (GO:0090141)	3.39063957
37	synapse assembly (GO:0007416)	3.33050779
38	dendritic spine morphogenesis (GO:0060997)	3.32172735
39	protein localization to cilium (GO:0061512)	3.31397505
40	negative regulation of axon guidance (GO:1902668)	3.28838456
41	neuronal ion channel clustering (GO:0045161)	3.26568562
42	response to pheromone (GO:0019236)	3.25540846
43	positive regulation of amino acid transport (GO:0051957)	3.23168503
44	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.23151814
45	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.16264436
46	regulation of translation, ncRNA-mediated (GO:0045974)	3.16264436
47	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.16264436
48	cochlea development (GO:0090102)	3.16171085
49	cardiac ventricle formation (GO:0003211)	3.15593259
50	establishment of mitochondrion localization (GO:0051654)	3.10452265
51	proline transport (GO:0015824)	3.09866965
52	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	3.09730723
53	substrate-independent telencephalic tangential migration (GO:0021826)	3.09730723
54	neuron fate determination (GO:0048664)	3.09616588
55	positive regulation of oligodendrocyte differentiation (GO:0048714)	3.09559739
56	ephrin receptor signaling pathway (GO:0048013)	3.05904608
57	startle response (GO:0001964)	3.02879113
58	forebrain neuron differentiation (GO:0021879)	3.02382475
59	dendrite morphogenesis (GO:0048813)	3.01707404
60	intraciliary transport (GO:0042073)	2.99475115
61	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	2.97029507
62	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	2.97029507
63	ionotropic glutamate receptor signaling pathway (GO:0035235)	2.95404108
64	ribonucleoprotein complex disassembly (GO:0032988)	2.94801056
65	axonogenesis (GO:0007409)	2.89735139
66	cilium or flagellum-dependent cell motility (GO:0001539)	2.88045844
67	epithelial cilium movement (GO:0003351)	2.87270930
68	positive regulation of dendritic spine morphogenesis (GO:0061003)	2.85989801
69	organelle transport along microtubule (GO:0072384)	2.85804358
70	cardiac chamber formation (GO:0003207)	2.85592820
71	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.85365738
72	negative regulation of axonogenesis (GO:0050771)	2.83599385
73	peristalsis (GO:0030432)	2.83005202
74	neuron cell-cell adhesion (GO:0007158)	2.82703357
75	hippocampus development (GO:0021766)	2.79453186
76	regulation of synapse structural plasticity (GO:0051823)	2.78862888
77	synaptic transmission, cholinergic (GO:0007271)	2.77808368
78	establishment of nucleus localization (GO:0040023)	2.77323767
79	glutamate receptor signaling pathway (GO:0007215)	2.75368647
80	microtubule depolymerization (GO:0007019)	2.75366227
81	eyelid development in camera-type eye (GO:0061029)	2.74144861
82	hindbrain development (GO:0030902)	2.73562191
83	regulation of axon guidance (GO:1902667)	2.73340260
84	protein polyglutamylation (GO:0018095)	2.73333708
85	neuron migration (GO:0001764)	2.73044162
86	reflex (GO:0060004)	2.71261720
87	regulation of short-term neuronal synaptic plasticity (GO:0048172)	2.70424570
88	response to auditory stimulus (GO:0010996)	2.69410907
89	neuronal action potential (GO:0019228)	2.68957696
90	regulation of glutamate secretion (GO:0014048)	2.68813032
91	regulation of extent of cell growth (GO:0061387)	2.66999593
92	head development (GO:0060322)	2.66727505
93	negative regulation of mast cell activation (GO:0033004)	2.66519145
94	righting reflex (GO:0060013)	2.65819081
95	nonmotile primary cilium assembly (GO:0035058)	2.65145155
96	inner ear receptor stereocilium organization (GO:0060122)	2.64497303
97	adult walking behavior (GO:0007628)	2.63461546
98	embryonic epithelial tube formation (GO:0001838)	2.60878018
99	regulation of sarcomere organization (GO:0060297)	2.60287128
100	glycosphingolipid biosynthetic process (GO:0006688)	2.59049606

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	IGF1R_20145208_ChIP-Seq_DFB_Human	4.62417666
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.69996110
3	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.38546940
4	RBPJ_22232070_ChIP-Seq_NCS_Mouse	3.32005002
5	GBX2_23144817_ChIP-Seq_PC3_Human	3.31806035
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	3.07257006
7	ZNF274_21170338_ChIP-Seq_K562_Hela	3.02897337
8	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.93786017
9	TAF15_26573619_Chip-Seq_HEK293_Human	2.90580364
10	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.77732194
11	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.72979751
12	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.59306356
13	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.54852948
14	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.48619246
15	P300_19829295_ChIP-Seq_ESCs_Human	2.14854565
16	EWS_26573619_Chip-Seq_HEK293_Human	2.13147923
17	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	2.11972510
18	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.08344329
19	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.07724643
20	FUS_26573619_Chip-Seq_HEK293_Human	2.07326819
21	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.96476060
22	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.93683257
23	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.91200803
24	SMAD4_21799915_ChIP-Seq_A2780_Human	1.85939525
25	RNF2_27304074_Chip-Seq_NSC_Mouse	1.84212137
26	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.84179556
27	VDR_22108803_ChIP-Seq_LS180_Human	1.82660850
28	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.81628305
29	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.80174689
30	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.80174689
31	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.78602233
32	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.77038557
33	IRF1_19129219_ChIP-ChIP_H3396_Human	1.73798476
34	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.72249772
35	REST_21632747_ChIP-Seq_MESCs_Mouse	1.69296593
36	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.69266929
37	ER_23166858_ChIP-Seq_MCF-7_Human	1.66362634
38	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.65129537
39	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.64821443
40	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.62397550
41	AR_25329375_ChIP-Seq_VCAP_Human	1.60115867
42	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.55542197
43	STAT3_23295773_ChIP-Seq_U87_Human	1.55493130
44	AR_21572438_ChIP-Seq_LNCaP_Human	1.54095498
45	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.52747883
46	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.47939073
47	CBP_20019798_ChIP-Seq_JUKART_Human	1.47939073
48	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.45736685
49	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.43705989
50	TCF4_23295773_ChIP-Seq_U87_Human	1.43315712
51	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.42923631
52	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.40823742
53	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.40427685
54	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.36124301
55	RUNX2_22187159_ChIP-Seq_PCA_Human	1.36016415
56	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.35454115
57	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.31694823
58	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.26791891
59	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.25346245
60	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.25145343
61	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.23471296
62	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.21029476
63	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.20463322
64	SOX9_26525672_Chip-Seq_HEART_Mouse	1.18451711
65	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.16854502
66	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.16278146
67	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.14750213
68	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.12803555
69	TCF4_22108803_ChIP-Seq_LS180_Human	1.12368878
70	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.11650043
71	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.11621463
72	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.11423234
73	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.11396983
74	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.11384970
75	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.11186862
76	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.09297876
77	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.08687864
78	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.08212051
79	P53_22387025_ChIP-Seq_ESCs_Mouse	1.05648991
80	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.05096365
81	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	1.04960063
82	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.01537827
83	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.01311293
84	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	0.99482673
85	JUN_21703547_ChIP-Seq_K562_Human	0.99343166
86	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.99241912
87	SUZ12_27294783_Chip-Seq_ESCs_Mouse	0.98765075
88	AR_19668381_ChIP-Seq_PC3_Human	0.98317596
89	TP53_22573176_ChIP-Seq_HFKS_Human	0.98213580
90	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.98087471
91	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.97964765
92	DROSHA_22980978_ChIP-Seq_HELA_Human	0.97159540
93	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.96061988
94	RXR_22108803_ChIP-Seq_LS180_Human	0.95942823
95	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.95814124
96	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.95221581
97	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.95201150
98	BCAT_22108803_ChIP-Seq_LS180_Human	0.94955385
99	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.94683690
100	KDM2B_26808549_Chip-Seq_REH_Human	0.94204405

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003880_abnormal_central_pattern	6.14113929
2	MP0000778_abnormal_nervous_system	3.59182468
3	MP0001529_abnormal_vocalization	3.00730113
4	MP0006276_abnormal_autonomic_nervous	2.64436607
5	MP0003122_maternal_imprinting	2.60449205
6	MP0005423_abnormal_somatic_nervous	2.51446017
7	MP0004270_analgesia	2.49010791
8	MP0000569_abnormal_digit_pigmentation	2.25675278
9	MP0001984_abnormal_olfaction	2.16814929
10	MP0004859_abnormal_synaptic_plasticity	2.13855909
11	MP0002736_abnormal_nociception_after	2.12167476
12	MP0002234_abnormal_pharynx_morphology	2.03964403
13	MP0001486_abnormal_startle_reflex	2.00490187
14	MP0004133_heterotaxia	1.98774101
15	MP0001968_abnormal_touch/_nociception	1.95516124
16	MP0003121_genomic_imprinting	1.94866039
17	MP0002751_abnormal_autonomic_nervous	1.92817122
18	MP0003635_abnormal_synaptic_transmissio	1.91938621
19	MP0005394_taste/olfaction_phenotype	1.91328525
20	MP0005499_abnormal_olfactory_system	1.91328525
21	MP0002102_abnormal_ear_morphology	1.87668706
22	MP0009046_muscle_twitch	1.78283859
23	MP0006292_abnormal_olfactory_placode	1.74515866
24	MP0008789_abnormal_olfactory_epithelium	1.73042001
25	MP0004924_abnormal_behavior	1.71865471
26	MP0005386_behavior/neurological_phenoty	1.71865471
27	MP0002063_abnormal_learning/memory/cond	1.67578499
28	MP0003221_abnormal_cardiomyocyte_apopto	1.64767192
29	MP0005551_abnormal_eye_electrophysiolog	1.62524944
30	MP0005253_abnormal_eye_physiology	1.61363368
31	MP0006072_abnormal_retinal_apoptosis	1.60232794
32	MP0003787_abnormal_imprinting	1.59769331
33	MP0002734_abnormal_mechanical_nocicepti	1.58833330
34	MP0002735_abnormal_chemical_nociception	1.57063173
35	MP0002272_abnormal_nervous_system	1.56174659
36	MP0002557_abnormal_social/conspecific_i	1.56063783
37	MP0005645_abnormal_hypothalamus_physiol	1.55972053
38	MP0002184_abnormal_innervation	1.55680416
39	MP0002067_abnormal_sensory_capabilities	1.53867333
40	MP0002882_abnormal_neuron_morphology	1.52971937
41	MP0009745_abnormal_behavioral_response	1.51346985
42	MP0004811_abnormal_neuron_physiology	1.51334406
43	MP0003890_abnormal_embryonic-extraembry	1.45882920
44	MP0002653_abnormal_ependyma_morphology	1.44469566
45	MP0002928_abnormal_bile_duct	1.43067048
46	MP0002752_abnormal_somatic_nervous	1.41365663
47	MP0002572_abnormal_emotion/affect_behav	1.41231542
48	MP0002233_abnormal_nose_morphology	1.38716166
49	MP0003861_abnormal_nervous_system	1.36237256
50	MP0003567_abnormal_fetal_cardiomyocyte	1.35220363
51	MP0004742_abnormal_vestibular_system	1.32471593
52	MP0002638_abnormal_pupillary_reflex	1.32285517
53	MP0001293_anophthalmia	1.32079578
54	MP0002822_catalepsy	1.29174772
55	MP0002152_abnormal_brain_morphology	1.28672180
56	MP0000955_abnormal_spinal_cord	1.28616090
57	MP0000631_abnormal_neuroendocrine_gland	1.27702198
58	MP0004215_abnormal_myocardial_fiber	1.24909141
59	MP0008995_early_reproductive_senescence	1.24626904
60	MP0002064_seizures	1.20168889
61	MP0000647_abnormal_sebaceous_gland	1.13435151
62	MP0005195_abnormal_posterior_eye	1.12676414
63	MP0005391_vision/eye_phenotype	1.09982467
64	MP0000049_abnormal_middle_ear	1.08691048
65	MP0001188_hyperpigmentation	1.05907586
66	MP0001970_abnormal_pain_threshold	1.05735041
67	MP0005187_abnormal_penis_morphology	1.03747227
68	MP0004145_abnormal_muscle_electrophysio	1.03717805
69	MP0004142_abnormal_muscle_tone	1.03430786
70	MP0010386_abnormal_urinary_bladder	0.97618323
71	MP0000026_abnormal_inner_ear	0.96753318
72	MP0001905_abnormal_dopamine_level	0.96347433
73	MP0002837_dystrophic_cardiac_calcinosis	0.96263750
74	MP0003755_abnormal_palate_morphology	0.95901730
75	MP0005367_renal/urinary_system_phenotyp	0.94359681
76	MP0000516_abnormal_urinary_system	0.94359681
77	MP0002069_abnormal_eating/drinking_beha	0.94296951
78	MP0001299_abnormal_eye_distance/	0.91508598
79	MP0001485_abnormal_pinna_reflex	0.91258729
80	MP0005084_abnormal_gallbladder_morpholo	0.90971651
81	MP0004043_abnormal_pH_regulation	0.90711787
82	MP0002909_abnormal_adrenal_gland	0.86442931
83	MP0003938_abnormal_ear_development	0.86001333
84	MP0002066_abnormal_motor_capabilities/c	0.85832543
85	MP0002229_neurodegeneration	0.84993686
86	MP0002081_perinatal_lethality	0.84340994
87	MP0003119_abnormal_digestive_system	0.84141887
88	MP0000534_abnormal_ureter_morphology	0.83750047
89	MP0000538_abnormal_urinary_bladder	0.82187562
90	MP0001177_atelectasis	0.82124052
91	MP0002733_abnormal_thermal_nociception	0.81489239
92	MP0002938_white_spotting	0.80769752
93	MP0005248_abnormal_Harderian_gland	0.79809964
94	MP0004885_abnormal_endolymph	0.78568611
95	MP0003937_abnormal_limbs/digits/tail_de	0.78505100
96	MP0008877_abnormal_DNA_methylation	0.78451193
97	MP0006035_abnormal_mitochondrial_morpho	0.75192129
98	MP0003633_abnormal_nervous_system	0.74653230
99	MP0003698_abnormal_male_reproductive	0.72830580
100	MP0000372_irregular_coat_pigmentation	0.71018657

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Drooling (HP:0002307)	3.72571222
2	Excessive salivation (HP:0003781)	3.44849163
3	Nephronophthisis (HP:0000090)	3.16270142
4	Absent speech (HP:0001344)	3.12606808
5	Lissencephaly (HP:0001339)	3.10000858
6	Pancreatic fibrosis (HP:0100732)	3.09472663
7	Chronic hepatic failure (HP:0100626)	3.07037676
8	Retinal dysplasia (HP:0007973)	3.03788850
9	Limb dystonia (HP:0002451)	3.03718241
10	Febrile seizures (HP:0002373)	3.03545750
11	Focal seizures (HP:0007359)	2.92285099
12	Abnormality of midbrain morphology (HP:0002418)	2.86581362
13	Molar tooth sign on MRI (HP:0002419)	2.86581362
14	Cortical dysplasia (HP:0002539)	2.85976259
15	Gait imbalance (HP:0002141)	2.85914802
16	Medial flaring of the eyebrow (HP:0010747)	2.83133538
17	Abnormality of the labia minora (HP:0012880)	2.80997375
18	Polyphagia (HP:0002591)	2.80396650
19	High anterior hairline (HP:0009890)	2.73709526
20	Abnormality of the renal medulla (HP:0100957)	2.71876876
21	Pancreatic cysts (HP:0001737)	2.69958511
22	Hyperglycinemia (HP:0002154)	2.69361546
23	Congenital primary aphakia (HP:0007707)	2.68620190
24	True hermaphroditism (HP:0010459)	2.67316311
25	Genital tract atresia (HP:0001827)	2.63101490
26	Broad alveolar ridges (HP:0000187)	2.58814754
27	Vaginal atresia (HP:0000148)	2.57081206
28	Exotropia (HP:0000577)	2.56852088
29	Focal motor seizures (HP:0011153)	2.55506247
30	Tented upper lip vermilion (HP:0010804)	2.52664812
31	Long clavicles (HP:0000890)	2.49800469
32	Hyperventilation (HP:0002883)	2.48224733
33	Nephrogenic diabetes insipidus (HP:0009806)	2.46461335
34	Broad-based gait (HP:0002136)	2.44376602
35	Volvulus (HP:0002580)	2.43288900
36	Abnormality of macular pigmentation (HP:0008002)	2.41192802
37	Narrow forehead (HP:0000341)	2.38994078
38	Tubulointerstitial nephritis (HP:0001970)	2.38504871
39	Atonic seizures (HP:0010819)	2.37255065
40	Protruding tongue (HP:0010808)	2.33047544
41	Pachygyria (HP:0001302)	2.31114010
42	Abnormality of the intervertebral disk (HP:0005108)	2.30756743
43	Small hand (HP:0200055)	2.29188965
44	Optic nerve hypoplasia (HP:0000609)	2.26181675
45	Abnormality of the metopic suture (HP:0005556)	2.25970265
46	Postaxial hand polydactyly (HP:0001162)	2.25946089
47	Amyotrophic lateral sclerosis (HP:0007354)	2.24306333
48	Hypoplasia of the brainstem (HP:0002365)	2.24197600
49	Aplasia/Hypoplasia of the brainstem (HP:0007362)	2.24197600
50	Inability to walk (HP:0002540)	2.23269359
51	Megalencephaly (HP:0001355)	2.22141371
52	Intestinal atresia (HP:0011100)	2.18889386
53	Polymicrogyria (HP:0002126)	2.17089306
54	Cupped ear (HP:0000378)	2.16624867
55	Hepatoblastoma (HP:0002884)	2.15677634
56	Renal hypoplasia (HP:0000089)	2.15481849
57	Hypothermia (HP:0002045)	2.13935897
58	Epidermoid cyst (HP:0200040)	2.11759323
59	Impaired vibration sensation in the lower limbs (HP:0002166)	2.10770712
60	Abnormality of salivation (HP:0100755)	2.08912957
61	Muscular hypotonia of the trunk (HP:0008936)	2.08620628
62	Specific learning disability (HP:0001328)	2.08429300
63	Amblyopia (HP:0000646)	2.08421093
64	Patellar aplasia (HP:0006443)	2.06151318
65	Aplasia/Hypoplasia of the patella (HP:0006498)	2.04280938
66	Poor coordination (HP:0002370)	2.03422244
67	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.03118132
68	Limb hypertonia (HP:0002509)	2.01255908
69	Congenital hepatic fibrosis (HP:0002612)	2.00600290
70	Micropenis (HP:0000054)	1.98166769
71	Decreased testicular size (HP:0008734)	1.96676091
72	Epileptic encephalopathy (HP:0200134)	1.93776197
73	Hypsarrhythmia (HP:0002521)	1.92641558
74	Short 4th metacarpal (HP:0010044)	1.92419973
75	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	1.92419973
76	Dialeptic seizures (HP:0011146)	1.91234790
77	Congenital stationary night blindness (HP:0007642)	1.91172295
78	Abnormality of the lower motor neuron (HP:0002366)	1.90317131
79	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.90195379
80	Abnormal social behavior (HP:0012433)	1.89604172
81	Impaired social interactions (HP:0000735)	1.89604172
82	Abnormality of the pubic bones (HP:0003172)	1.89297386
83	Severe Myopia (HP:0011003)	1.89153795
84	Abolished electroretinogram (ERG) (HP:0000550)	1.87942748
85	Type II lissencephaly (HP:0007260)	1.87257038
86	Supernumerary spleens (HP:0009799)	1.86724542
87	Anophthalmia (HP:0000528)	1.86308494
88	Spastic tetraplegia (HP:0002510)	1.86027903
89	Cystic liver disease (HP:0006706)	1.85647655
90	EEG with generalized epileptiform discharges (HP:0011198)	1.82202895
91	Anencephaly (HP:0002323)	1.81452466
92	Degeneration of the lateral corticospinal tracts (HP:0002314)	1.80676276
93	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	1.80676276
94	Tubulointerstitial abnormality (HP:0001969)	1.79103599
95	Wrist flexion contracture (HP:0001239)	1.78350899
96	Oligodactyly (hands) (HP:0001180)	1.77585475
97	Postaxial foot polydactyly (HP:0001830)	1.77557475
98	Abnormality of the renal cortex (HP:0011035)	1.77484047
99	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.77310035
100	Sclerocornea (HP:0000647)	1.77268729

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MARK1	5.09245685
2	WNK3	4.93150942
3	CASK	4.55900337
4	MAP4K2	4.05635539
5	MAP3K4	3.75126250
6	TRIM28	3.11644955
7	BCR	3.09674431
8	MAP2K7	3.07453289
9	EPHA4	2.74512290
10	MAPK13	2.44773023
11	ERBB3	2.12360053
12	FRK	2.07814206
13	DYRK3	1.94228370
14	ADRBK2	1.92822096
15	PAK3	1.90023390
16	DYRK2	1.72054740
17	KSR1	1.69513638
18	NTRK3	1.57630039
19	CSNK1G2	1.50037281
20	MAP2K4	1.47252639
21	BCKDK	1.45422842
22	EPHB2	1.28888716
23	EPHA3	1.21955356
24	CAMKK2	1.21656496
25	MINK1	1.17077952
26	CSNK1G3	1.15771831
27	GRK1	1.15398837
28	SIK3	1.13075237
29	NTRK2	1.09709643
30	SRPK1	1.08230171
31	MAP3K6	1.07619652
32	CDK19	1.03988365
33	MKNK2	1.01600196
34	MKNK1	0.97738620
35	UHMK1	0.97109614
36	DYRK1B	0.93803825
37	CSNK1G1	0.92426320
38	CSNK1A1L	0.90460429
39	DYRK1A	0.82551706
40	PAK6	0.79088252
41	CAMK4	0.76230182
42	PKN1	0.74455954
43	RPS6KA4	0.72245267
44	PLK2	0.71919892
45	CAMK2A	0.67687273
46	WNK4	0.66356282
47	NUAK1	0.65606842
48	RAF1	0.63620611
49	CDK5	0.63529611
50	SIK2	0.60289621
51	CAMK1	0.58339861
52	PRKCZ	0.57721549
53	FER	0.57702079
54	CDK18	0.56621109
55	STK38L	0.55968349
56	PRKCE	0.53937504
57	STK39	0.53605632
58	CDK3	0.52830281
59	YES1	0.52247980
60	ERBB2	0.52007483
61	INSRR	0.51611679
62	CAMK2B	0.51395813
63	CDK14	0.50686412
64	PRKCG	0.49369542
65	CDK15	0.46213398
66	BRD4	0.46115306
67	CAMK1G	0.45857559
68	CAMK1D	0.45588919
69	PINK1	0.44819354
70	PRKAA1	0.44659982
71	CDK11A	0.44648891
72	OXSR1	0.44107142
73	ILK	0.41733877
74	DAPK2	0.40689426
75	CSNK1D	0.39143234
76	SGK223	0.38527002
77	SGK494	0.38527002
78	AKT3	0.37842491
79	PRKG1	0.36177277
80	PRKACA	0.35689692
81	MAPK8	0.34002072
82	ADRBK1	0.33789218
83	CSNK1E	0.33582115
84	TNIK	0.31866788
85	MAP3K5	0.31807988
86	SGK2	0.30618237
87	PRKACB	0.30012153
88	BMPR1B	0.28904537
89	MAPK9	0.27844045
90	PRKACG	0.26180167
91	PHKG1	0.26154531
92	PHKG2	0.26154531
93	GSK3B	0.25992732
94	DMPK	0.25747043
95	PRKCB	0.24527678
96	CAMK2D	0.23993013
97	FGR	0.23411920
98	RPS6KA3	0.22517802
99	MARK2	0.22465150
100	ATM	0.21493042

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	4.37416075
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.31898540
3	Steroid biosynthesis_Homo sapiens_hsa00100	2.83744344
4	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	2.78591081
5	Phototransduction_Homo sapiens_hsa04744	2.32750887
6	GABAergic synapse_Homo sapiens_hsa04727	2.32260540
7	Glutamatergic synapse_Homo sapiens_hsa04724	2.25084205
8	Taste transduction_Homo sapiens_hsa04742	2.24308193
9	Morphine addiction_Homo sapiens_hsa05032	2.17938603
10	Axon guidance_Homo sapiens_hsa04360	2.16224135
11	Dopaminergic synapse_Homo sapiens_hsa04728	2.08528950
12	Basal transcription factors_Homo sapiens_hsa03022	2.03059803
13	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.89891407
14	Butanoate metabolism_Homo sapiens_hsa00650	1.83983161
15	Circadian entrainment_Homo sapiens_hsa04713	1.80268101
16	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.76189909
17	Cocaine addiction_Homo sapiens_hsa05030	1.70739487
18	Protein export_Homo sapiens_hsa03060	1.62891853
19	Regulation of autophagy_Homo sapiens_hsa04140	1.55342981
20	Amphetamine addiction_Homo sapiens_hsa05031	1.53792434
21	Long-term depression_Homo sapiens_hsa04730	1.52008540
22	Serotonergic synapse_Homo sapiens_hsa04726	1.43587195
23	Propanoate metabolism_Homo sapiens_hsa00640	1.35922478
24	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.33801659
25	Fanconi anemia pathway_Homo sapiens_hsa03460	1.32789379
26	Olfactory transduction_Homo sapiens_hsa04740	1.31343458
27	Cholinergic synapse_Homo sapiens_hsa04725	1.30533154
28	Colorectal cancer_Homo sapiens_hsa05210	1.28733157
29	Insulin secretion_Homo sapiens_hsa04911	1.23275513
30	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.19684171
31	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.18391668
32	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.17507179
33	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.14297949
34	Linoleic acid metabolism_Homo sapiens_hsa00591	1.13740502
35	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.11844408
36	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.10250142
37	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.07907791
38	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.01739316
39	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.95969147
40	Ether lipid metabolism_Homo sapiens_hsa00565	0.95696194
41	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.94603782
42	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.92094472
43	Gap junction_Homo sapiens_hsa04540	0.91004867
44	ABC transporters_Homo sapiens_hsa02010	0.88316718
45	Non-homologous end-joining_Homo sapiens_hsa03450	0.88225672
46	Fatty acid metabolism_Homo sapiens_hsa01212	0.85506408
47	Tight junction_Homo sapiens_hsa04530	0.83647901
48	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.82184236
49	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.81809304
50	Alcoholism_Homo sapiens_hsa05034	0.80657485
51	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.78202973
52	Salivary secretion_Homo sapiens_hsa04970	0.77749806
53	Notch signaling pathway_Homo sapiens_hsa04330	0.76317926
54	Peroxisome_Homo sapiens_hsa04146	0.75731889
55	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.73901985
56	cAMP signaling pathway_Homo sapiens_hsa04024	0.73537801
57	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.73021262
58	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.71517506
59	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.71083558
60	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.69929236
61	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.67965495
62	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.67680419
63	RNA degradation_Homo sapiens_hsa03018	0.63687480
64	Fat digestion and absorption_Homo sapiens_hsa04975	0.63506541
65	Selenocompound metabolism_Homo sapiens_hsa00450	0.60792727
66	Ras signaling pathway_Homo sapiens_hsa04014	0.60680315
67	Oocyte meiosis_Homo sapiens_hsa04114	0.60434841
68	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.59570658
69	Type II diabetes mellitus_Homo sapiens_hsa04930	0.57523457
70	Parkinsons disease_Homo sapiens_hsa05012	0.55140927
71	AMPK signaling pathway_Homo sapiens_hsa04152	0.53081232
72	ErbB signaling pathway_Homo sapiens_hsa04012	0.50984413
73	Fatty acid elongation_Homo sapiens_hsa00062	0.50757799
74	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.50131136
75	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.49911804
76	Tryptophan metabolism_Homo sapiens_hsa00380	0.46064769
77	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.45825822
78	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.45773297
79	Hippo signaling pathway_Homo sapiens_hsa04390	0.45540454
80	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.45484607
81	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.44867777
82	Wnt signaling pathway_Homo sapiens_hsa04310	0.44622308
83	Calcium signaling pathway_Homo sapiens_hsa04020	0.44116026
84	Choline metabolism in cancer_Homo sapiens_hsa05231	0.43910212
85	Prolactin signaling pathway_Homo sapiens_hsa04917	0.41737117
86	Lysine degradation_Homo sapiens_hsa00310	0.41522625
87	mRNA surveillance pathway_Homo sapiens_hsa03015	0.36397757
88	Basal cell carcinoma_Homo sapiens_hsa05217	0.35880681
89	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.34676311
90	Sphingolipid metabolism_Homo sapiens_hsa00600	0.34445181
91	Caffeine metabolism_Homo sapiens_hsa00232	0.33756146
92	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.33464566
93	Collecting duct acid secretion_Homo sapiens_hsa04966	0.33041121
94	Cardiac muscle contraction_Homo sapiens_hsa04260	0.32936146
95	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.32718277
96	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.32647446
97	Melanoma_Homo sapiens_hsa05218	0.32385222
98	Huntingtons disease_Homo sapiens_hsa05016	0.30849680
99	Rap1 signaling pathway_Homo sapiens_hsa04015	0.30703990
100	Gastric acid secretion_Homo sapiens_hsa04971	0.30697578

VN1R76P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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