ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	diol metabolic process (GO:0034311)	9.23210081
2	sphingoid metabolic process (GO:0046519)	9.09559066
3	DNA methylation involved in gamete generation (GO:0043046)	8.97886872
4	lipopolysaccharide biosynthetic process (GO:0009103)	8.06056785
5	piRNA metabolic process (GO:0034587)	7.75056483
6	regulation of meiosis I (GO:0060631)	7.65304866
7	lipopolysaccharide metabolic process (GO:0008653)	7.05062527
8	regulation of odontogenesis of dentin-containing tooth (GO:0042487)	5.58370744
9	protein-chromophore linkage (GO:0018298)	5.34377877
10	positive regulation of developmental pigmentation (GO:0048087)	5.24733447
11	regulation of protein glycosylation (GO:0060049)	5.14426208
12	regulation of pigment cell differentiation (GO:0050932)	5.12412759
13	sulfate transmembrane transport (GO:1902358)	4.73109589
14	positive regulation of meiosis (GO:0045836)	4.68164451
15	negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)	4.47246634
16	positive regulation of meiotic cell cycle (GO:0051446)	4.32596011
17	sulfate transport (GO:0008272)	4.26852230
18	meiotic chromosome segregation (GO:0045132)	4.24142241
19	indolalkylamine metabolic process (GO:0006586)	4.21727347
20	regulation of rhodopsin mediated signaling pathway (GO:0022400)	4.03274839
21	regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)	3.92221841
22	cellular ketone body metabolic process (GO:0046950)	3.91955922
23	tyrosine metabolic process (GO:0006570)	3.84572588
24	negative regulation of mast cell activation (GO:0033004)	3.84448638
25	ribonucleoprotein complex disassembly (GO:0032988)	3.83976265
26	centriole replication (GO:0007099)	3.81090590
27	rhodopsin mediated signaling pathway (GO:0016056)	3.74056387
28	negative regulation of cell cycle G2/M phase transition (GO:1902750)	3.67091052
29	L-phenylalanine catabolic process (GO:0006559)	3.62998035
30	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	3.62998035
31	gamma-aminobutyric acid signaling pathway (GO:0007214)	3.60100720
32	behavioral response to nicotine (GO:0035095)	3.54560796
33	aromatic amino acid family catabolic process (GO:0009074)	3.52057616
34	reflex (GO:0060004)	3.44977536
35	ketone body metabolic process (GO:1902224)	3.43359987
36	tryptophan catabolic process (GO:0006569)	3.42332798
37	indole-containing compound catabolic process (GO:0042436)	3.42332798
38	indolalkylamine catabolic process (GO:0046218)	3.42332798
39	signal peptide processing (GO:0006465)	3.39575471
40	kynurenine metabolic process (GO:0070189)	3.37443081
41	heme transport (GO:0015886)	3.36782414
42	nodal signaling pathway (GO:0038092)	3.35874329
43	multicellular organism reproduction (GO:0032504)	3.34410548
44	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	3.27987102
45	indole-containing compound metabolic process (GO:0042430)	3.25679521
46	primary amino compound metabolic process (GO:1901160)	3.25091095
47	tachykinin receptor signaling pathway (GO:0007217)	3.23553030
48	adaptation of signaling pathway (GO:0023058)	3.21409308
49	SMAD protein complex assembly (GO:0007183)	3.21364224
50	serotonin metabolic process (GO:0042428)	3.20876364
51	organelle disassembly (GO:1903008)	3.18847767
52	axoneme assembly (GO:0035082)	3.15572623
53	aspartate family amino acid catabolic process (GO:0009068)	3.15102011
54	DNA alkylation (GO:0006305)	3.11867779
55	DNA methylation (GO:0006306)	3.11867779
56	gene silencing by RNA (GO:0031047)	3.11274940
57	somite rostral/caudal axis specification (GO:0032525)	3.09675481
58	positive regulation of viral genome replication (GO:0045070)	3.07234347
59	regulation of transforming growth factor beta2 production (GO:0032909)	3.03527507
60	one-carbon compound transport (GO:0019755)	3.01268035
61	aromatic amino acid family metabolic process (GO:0009072)	3.00477153
62	lysine metabolic process (GO:0006553)	2.95287808
63	lysine catabolic process (GO:0006554)	2.95287808
64	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.93632126
65	opioid receptor signaling pathway (GO:0038003)	2.90512420
66	regulation of cilium movement (GO:0003352)	2.90216353
67	sulfur compound transport (GO:0072348)	2.89281259
68	pantothenate metabolic process (GO:0015939)	2.86781858
69	positive regulation of fatty acid oxidation (GO:0046321)	2.85490702
70	negative regulation of glycoprotein biosynthetic process (GO:0010561)	2.85261805
71	tryptophan metabolic process (GO:0006568)	2.82719961
72	inflammatory response to antigenic stimulus (GO:0002437)	2.81904010
73	serotonin receptor signaling pathway (GO:0007210)	2.81408684
74	DNA methylation or demethylation (GO:0044728)	2.81111828
75	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	2.80840335
76	L-phenylalanine metabolic process (GO:0006558)	2.80840335
77	negative regulation of appetite (GO:0032099)	2.79926834
78	negative regulation of response to food (GO:0032096)	2.79926834
79	organic cation transport (GO:0015695)	2.79669958
80	glycerol metabolic process (GO:0006071)	2.78076185
81	DNA deamination (GO:0045006)	2.74235987
82	L-fucose catabolic process (GO:0042355)	2.68528314
83	fucose catabolic process (GO:0019317)	2.68528314
84	L-fucose metabolic process (GO:0042354)	2.68528314
85	regulation of centrosome duplication (GO:0010824)	2.68406625
86	sympathetic nervous system development (GO:0048485)	2.67683248
87	tyrosine phosphorylation of STAT protein (GO:0007260)	2.67161781
88	reciprocal DNA recombination (GO:0035825)	2.65571143
89	reciprocal meiotic recombination (GO:0007131)	2.65571143
90	protein kinase C-activating G-protein coupled receptor signaling pathway (GO:0007205)	2.64835135
91	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	2.63116176
92	interleukin-6-mediated signaling pathway (GO:0070102)	2.63006334
93	protein polyglutamylation (GO:0018095)	2.60839185
94	autophagic vacuole fusion (GO:0000046)	2.60259996
95	cellular response to exogenous dsRNA (GO:0071360)	2.60094349
96	regulation of sequestering of triglyceride (GO:0010889)	2.58732322
97	auditory behavior (GO:0031223)	2.56635765
98	paraxial mesoderm development (GO:0048339)	2.54911435
99	vitamin transmembrane transport (GO:0035461)	2.54667878
100	sphingosine metabolic process (GO:0006670)	10.1848502

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	IGF1R_20145208_ChIP-Seq_DFB_Human	4.92821163
2	AR_21572438_ChIP-Seq_LNCaP_Human	3.64797898
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.44473795
4	VDR_22108803_ChIP-Seq_LS180_Human	2.99089624
5	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.90011418
6	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.84757385
7	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.70654543
8	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.56217857
9	ZNF274_21170338_ChIP-Seq_K562_Hela	2.45177608
10	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.36693652
11	ER_23166858_ChIP-Seq_MCF-7_Human	2.36623716
12	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.28701617
13	EZH2_22144423_ChIP-Seq_EOC_Human	2.26404788
14	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.05153854
15	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.98931842
16	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.96545920
17	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.89114811
18	P300_19829295_ChIP-Seq_ESCs_Human	1.87474409
19	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.74882641
20	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.65409014
21	TCF4_23295773_ChIP-Seq_U87_Human	1.64608716
22	AR_25329375_ChIP-Seq_VCAP_Human	1.61167029
23	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.60621827
24	SOX2_19829295_ChIP-Seq_ESCs_Human	1.59898062
25	NANOG_19829295_ChIP-Seq_ESCs_Human	1.59898062
26	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.59693484
27	STAT3_23295773_ChIP-Seq_U87_Human	1.57561569
28	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.54321521
29	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.54321521
30	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.48507083
31	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.47280540
32	HOXB7_26014856_ChIP-Seq_BT474_Human	1.47211927
33	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.45413392
34	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.44576527
35	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.44248164
36	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.42618357
37	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.39680345
38	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.39291864
39	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.38713563
40	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.37887861
41	TAF15_26573619_Chip-Seq_HEK293_Human	1.35574828
42	SMAD4_21799915_ChIP-Seq_A2780_Human	1.34682455
43	OCT4_20526341_ChIP-Seq_ESCs_Human	1.33132456
44	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.30747907
45	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.30123301
46	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.30049663
47	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.25709053
48	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.23918265
49	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.23119558
50	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.22617289
51	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.21548534
52	NCOR_22424771_ChIP-Seq_293T_Human	1.21368687
53	FUS_26573619_Chip-Seq_HEK293_Human	1.21366416
54	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.20508765
55	CBP_20019798_ChIP-Seq_JUKART_Human	1.20103663
56	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.20103663
57	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.18054778
58	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.16845793
59	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.16845793
60	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.15721874
61	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.15545286
62	EWS_26573619_Chip-Seq_HEK293_Human	1.14701825
63	EGR1_19032775_ChIP-ChIP_M12_Human	1.13115092
64	TCF4_22108803_ChIP-Seq_LS180_Human	1.12881452
65	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.12552296
66	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.11919480
67	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.11294909
68	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.11290249
69	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.11255129
70	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.09847743
71	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.09248950
72	BCAT_22108803_ChIP-Seq_LS180_Human	1.09227990
73	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.08849397
74	STAT1_20625510_ChIP-Seq_HELA_Human	1.08528984
75	TP53_22573176_ChIP-Seq_HFKS_Human	1.08346887
76	CEBPB_22108803_ChIP-Seq_LS180_Human	1.08327697
77	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.07104588
78	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.06919145
79	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.06638074
80	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.06343576
81	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.05558525
82	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.05556217
83	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.05391553
84	CDX2_22108803_ChIP-Seq_LS180_Human	1.02935613
85	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.02394051
86	REST_21632747_ChIP-Seq_MESCs_Mouse	1.02322570
87	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.01912550
88	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.01334143
89	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	1.00914527
90	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.99380346
91	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	0.98809573
92	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.98465807
93	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.97843579
94	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.95815986
95	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.95169050
96	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.94944174
97	RUNX2_22187159_ChIP-Seq_PCA_Human	0.94742315
98	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.94478383
99	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.93944317
100	P53_21459846_ChIP-Seq_SAOS-2_Human	0.93881880

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002837_dystrophic_cardiac_calcinosis	7.70530534
2	MP0003136_yellow_coat_color	6.10354431
3	MP0005171_absent_coat_pigmentation	5.71326419
4	MP0002653_abnormal_ependyma_morphology	4.42006989
5	MP0003890_abnormal_embryonic-extraembry	3.80975536
6	MP0003646_muscle_fatigue	3.55832462
7	MP0003045_fibrosis	3.46264846
8	MP0003879_abnormal_hair_cell	3.31019204
9	MP0002736_abnormal_nociception_after	2.99860389
10	MP0000569_abnormal_digit_pigmentation	2.69580848
11	MP0001968_abnormal_touch/_nociception	2.57563808
12	MP0004147_increased_porphyrin_level	2.45824908
13	MP0002735_abnormal_chemical_nociception	2.24937754
14	MP0004381_abnormal_hair_follicle	2.22020543
15	MP0003195_calcinosis	2.14818678
16	MP0001984_abnormal_olfaction	1.98680256
17	MP0002138_abnormal_hepatobiliary_system	1.85338631
18	MP0005085_abnormal_gallbladder_physiolo	1.74478458
19	MP0000427_abnormal_hair_cycle	1.71550683
20	MP0003137_abnormal_impulse_conducting	1.70321790
21	MP0005075_abnormal_melanosome_morpholog	1.62155200
22	MP0002938_white_spotting	1.56351713
23	MP0005670_abnormal_white_adipose	1.54539710
24	MP0005551_abnormal_eye_electrophysiolog	1.49850893
25	MP0000749_muscle_degeneration	1.48433018
26	MP0000372_irregular_coat_pigmentation	1.47614041
27	MP0002160_abnormal_reproductive_system	1.46209318
28	MP0005423_abnormal_somatic_nervous	1.45736076
29	MP0001486_abnormal_startle_reflex	1.45708322
30	MP0001970_abnormal_pain_threshold	1.45587137
31	MP0002168_other_aberrant_phenotype	1.41479745
32	MP0003787_abnormal_imprinting	1.40971099
33	MP0009745_abnormal_behavioral_response	1.35895642
34	MP0002272_abnormal_nervous_system	1.34046826
35	MP0002733_abnormal_thermal_nociception	1.29451912
36	MP0005410_abnormal_fertilization	1.29083519
37	MP0001501_abnormal_sleep_pattern	1.21819252
38	MP0008872_abnormal_physiological_respon	1.20489748
39	MP0009046_muscle_twitch	1.19578213
40	MP0003880_abnormal_central_pattern	1.19535082
41	MP0005365_abnormal_bile_salt	1.11830237
42	MP0001986_abnormal_taste_sensitivity	1.10045926
43	MP0009697_abnormal_copulation	1.00805319
44	MP0002064_seizures	0.98177970
45	MP0004130_abnormal_muscle_cell	0.93364891
46	MP0002095_abnormal_skin_pigmentation	0.93354789
47	MP0008569_lethality_at_weaning	0.92950745
48	MP0005647_abnormal_sex_gland	0.92733656
49	MP0002572_abnormal_emotion/affect_behav	0.91496464
50	MP0005389_reproductive_system_phenotype	0.89395439
51	MP0009764_decreased_sensitivity_to	0.88936768
52	MP0005395_other_phenotype	0.87160273
53	MP0008875_abnormal_xenobiotic_pharmacok	0.86261510
54	MP0001905_abnormal_dopamine_level	0.86039073
55	MP0003698_abnormal_male_reproductive	0.83120266
56	MP0008877_abnormal_DNA_methylation	0.82893047
57	MP0002734_abnormal_mechanical_nocicepti	0.82022173
58	MP0000685_abnormal_immune_system	0.81903114
59	MP0001529_abnormal_vocalization	0.76881951
60	MP0002876_abnormal_thyroid_physiology	0.76561156
61	MP0004043_abnormal_pH_regulation	0.76286791
62	MP0003635_abnormal_synaptic_transmissio	0.73722211
63	MP0001661_extended_life_span	0.73479601
64	MP0002067_abnormal_sensory_capabilities	0.72329490
65	MP0001800_abnormal_humoral_immune	0.70369948
66	MP0004142_abnormal_muscle_tone	0.70317302
67	MP0005387_immune_system_phenotype	0.69318762
68	MP0001790_abnormal_immune_system	0.69318762
69	MP0001440_abnormal_grooming_behavior	0.68690507
70	MP0004233_abnormal_muscle_weight	0.67940297
71	MP0005310_abnormal_salivary_gland	0.67616321
72	MP0010155_abnormal_intestine_physiology	0.66729926
73	MP0005646_abnormal_pituitary_gland	0.66505498
74	MP0003866_abnormal_defecation	0.65392807
75	MP0008058_abnormal_DNA_repair	0.64563500
76	MP0005448_abnormal_energy_balance	0.61768838
77	MP0005671_abnormal_response_to	0.60617786
78	MP0001929_abnormal_gametogenesis	0.60338775
79	MP0000230_abnormal_systemic_arterial	0.59732301
80	MP0006276_abnormal_autonomic_nervous	0.57450257
81	MP0004859_abnormal_synaptic_plasticity	0.57309806
82	MP0005386_behavior/neurological_phenoty	0.56772625
83	MP0004924_abnormal_behavior	0.56772625
84	MP0005167_abnormal_blood-brain_barrier	0.55600456
85	MP0005083_abnormal_biliary_tract	0.55595324
86	MP0008770_decreased_survivor_rate	0.55112616
87	MP0002229_neurodegeneration	0.54632037
88	MP0005319_abnormal_enzyme/_coenzyme	0.53234810
89	MP0001963_abnormal_hearing_physiology	0.52983243
90	MP0003959_abnormal_lean_body	0.52756281
91	MP0005253_abnormal_eye_physiology	0.52407638
92	MP0000026_abnormal_inner_ear	0.52345367
93	MP0002277_abnormal_respiratory_mucosa	0.51822151
94	MP0002102_abnormal_ear_morphology	0.51667425
95	MP0002933_joint_inflammation	0.50422106
96	MP0002063_abnormal_learning/memory/cond	0.50215365
97	MP0010386_abnormal_urinary_bladder	0.49627648
98	MP0002210_abnormal_sex_determination	0.49537083
99	MP0004133_heterotaxia	0.49442297
100	MP0002148_abnormal_hypersensitivity_rea	0.48821756

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Amelogenesis imperfecta (HP:0000705)	6.41816328
2	Focal motor seizures (HP:0011153)	6.33168046
3	Pancreatic cysts (HP:0001737)	5.80686857
4	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	5.25681557
5	Cerebellar dysplasia (HP:0007033)	5.06631249
6	Type II lissencephaly (HP:0007260)	4.87519928
7	Parakeratosis (HP:0001036)	4.39262068
8	Acanthocytosis (HP:0001927)	4.25330770
9	Pancreatic fibrosis (HP:0100732)	3.98699766
10	Congenital stationary night blindness (HP:0007642)	3.94943258
11	Ulnar claw (HP:0001178)	3.80432984
12	True hermaphroditism (HP:0010459)	3.59828157
13	Nephronophthisis (HP:0000090)	3.47596091
14	Abnormality of the renal cortex (HP:0011035)	3.43309684
15	Cystic liver disease (HP:0006706)	3.37671033
16	Dialeptic seizures (HP:0011146)	3.27978679
17	Abnormality of the renal medulla (HP:0100957)	3.24640281
18	Pendular nystagmus (HP:0012043)	3.20730290
19	Occipital encephalocele (HP:0002085)	3.15871155
20	Abnormality of macular pigmentation (HP:0008002)	3.04920068
21	Aplastic anemia (HP:0001915)	3.03198681
22	Congenital ichthyosiform erythroderma (HP:0007431)	3.00255330
23	Colon cancer (HP:0003003)	2.97870469
24	Difficulty walking (HP:0002355)	2.97562387
25	Poikilocytosis (HP:0004447)	2.80350912
26	Erythroderma (HP:0001019)	2.79374149
27	Retinal dysplasia (HP:0007973)	2.77480342
28	Rectal prolapse (HP:0002035)	2.66474341
29	Abnormal biliary tract physiology (HP:0012439)	2.65526806
30	Bile duct proliferation (HP:0001408)	2.65526806
31	IgM deficiency (HP:0002850)	2.59768516
32	Chronic hepatic failure (HP:0100626)	2.48493385
33	Focal seizures (HP:0007359)	2.44633526
34	Absent/shortened dynein arms (HP:0200106)	2.42680640
35	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.42680640
36	Increased corneal curvature (HP:0100692)	2.41926029
37	Keratoconus (HP:0000563)	2.41926029
38	Potter facies (HP:0002009)	2.36076396
39	Facial shape deformation (HP:0011334)	2.36076396
40	Broad ribs (HP:0000885)	2.33109178
41	Birth length less than 3rd percentile (HP:0003561)	2.32852806
42	Spontaneous hematomas (HP:0007420)	2.32765652
43	Large for gestational age (HP:0001520)	2.32129256
44	Petechiae (HP:0000967)	2.30810676
45	Proximal amyotrophy (HP:0007126)	2.29309705
46	Tubular atrophy (HP:0000092)	2.27605017
47	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.27402587
48	Furrowed tongue (HP:0000221)	2.26885324
49	Chronic diarrhea (HP:0002028)	2.24907444
50	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.23654247
51	Congenital hepatic fibrosis (HP:0002612)	2.21901802
52	Abnormal drinking behavior (HP:0030082)	2.18889108
53	Polydipsia (HP:0001959)	2.18889108
54	Chorioretinal atrophy (HP:0000533)	2.18445687
55	Hematochezia (HP:0002573)	2.16749893
56	Lissencephaly (HP:0001339)	2.15659533
57	Severe visual impairment (HP:0001141)	2.14750773
58	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.11426592
59	Progressive inability to walk (HP:0002505)	2.09918014
60	Overlapping toe (HP:0001845)	2.07213102
61	Scapular winging (HP:0003691)	2.04919837
62	Broad-based gait (HP:0002136)	2.03903242
63	Radial bowing (HP:0002986)	2.03728277
64	IgA deficiency (HP:0002720)	2.01005169
65	Patellar aplasia (HP:0006443)	2.00306412
66	Anencephaly (HP:0002323)	2.00072033
67	Decreased central vision (HP:0007663)	1.98877632
68	Hypothermia (HP:0002045)	1.98586619
69	Ketosis (HP:0001946)	1.96378155
70	Inability to walk (HP:0002540)	1.95295677
71	Aplasia/Hypoplasia of the patella (HP:0006498)	1.94253115
72	Tinnitus (HP:0000360)	1.93908257
73	Retinitis pigmentosa (HP:0000510)	1.93868147
74	Absent speech (HP:0001344)	1.92399735
75	Clumsiness (HP:0002312)	1.90372581
76	Pigmentary retinal degeneration (HP:0001146)	1.86484425
77	Gaze-evoked nystagmus (HP:0000640)	1.85849011
78	Abnormality of alanine metabolism (HP:0010916)	1.85602116
79	Hyperalaninemia (HP:0003348)	1.85602116
80	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.85602116
81	Attenuation of retinal blood vessels (HP:0007843)	1.85456624
82	Abnormality of the vocal cords (HP:0008777)	1.85201023
83	Supernumerary spleens (HP:0009799)	1.85130755
84	IgG deficiency (HP:0004315)	1.84984576
85	Tubulointerstitial fibrosis (HP:0005576)	1.83299080
86	Abnormality of aromatic amino acid family metabolism (HP:0004338)	1.81302238
87	Widely spaced teeth (HP:0000687)	1.81240488
88	Abnormality of the shoulder girdle musculature (HP:0001435)	1.78274792
89	Portal hypertension (HP:0001409)	1.77324519
90	Sclerocornea (HP:0000647)	1.77299547
91	Hypoalbuminemia (HP:0003073)	1.77272364
92	Abnormal albumin level (HP:0012116)	1.77272364
93	Abnormality of glycine metabolism (HP:0010895)	1.74202777
94	Abnormality of serine family amino acid metabolism (HP:0010894)	1.74202777
95	Cutaneous melanoma (HP:0012056)	1.73964630
96	Hypokalemia (HP:0002900)	1.73465063
97	Abnormal rod and cone electroretinograms (HP:0008323)	1.69998447
98	Ileus (HP:0002595)	1.69124255
99	Autoimmune hemolytic anemia (HP:0001890)	1.67076524
100	Ketoacidosis (HP:0001993)	1.65992846

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	LATS1	8.47952982
2	STK38L	5.51360781
3	ACVR1B	4.79780914
4	FRK	4.79498142
5	LATS2	4.77348191
6	ZAK	3.26180233
7	STK38	2.40260586
8	BMPR1B	2.25671718
9	MAPKAPK3	1.99217529
10	STK3	1.84505567
11	NLK	1.84258714
12	MELK	1.72186921
13	TAOK3	1.66985165
14	PRKD3	1.64944833
15	MAP2K2	1.56904003
16	ADRBK2	1.39090639
17	WNK3	1.27491192
18	MAP3K2	1.25510209
19	PLK4	1.19602901
20	PINK1	1.19350033
21	PIK3CG	1.17415364
22	NEK2	1.09031336
23	MAP3K4	1.07087146
24	CASK	1.06601722
25	BMX	0.99924878
26	CSNK1A1L	0.96340524
27	TEC	0.96053122
28	OXSR1	0.93564191
29	ADRBK1	0.93526317
30	TGFBR1	0.90720127
31	PRKAA2	0.87731110
32	NUAK1	0.83673363
33	WNK4	0.82439511
34	PHKG1	0.80970173
35	PHKG2	0.80970173
36	TNK2	0.79836698
37	GRK1	0.77885506
38	FER	0.76865593
39	TXK	0.75483765
40	SIK2	0.67034302
41	MARK1	0.66614076
42	CAMKK2	0.66558176
43	CCNB1	0.64911475
44	MAP2K7	0.62422372
45	RIPK4	0.62199656
46	GRK7	0.60899041
47	PDPK1	0.60215421
48	DAPK2	0.55138111
49	TTK	0.54318142
50	MAPK13	0.53536066
51	BRSK2	0.49191774
52	CSNK1G3	0.48036289
53	MAP2K1	0.47739817
54	EIF2AK3	0.47152410
55	MUSK	0.46694818
56	KDR	0.45769686
57	STK39	0.45762344
58	GRK5	0.45587552
59	IRAK4	0.45485861
60	PIM1	0.45384087
61	ITK	0.42980439
62	TAF1	0.42057588
63	CSNK1G2	0.41762828
64	BCR	0.39827077
65	DAPK1	0.38971736
66	CSNK1D	0.37875797
67	CDK19	0.37012368
68	ERBB3	0.35739793
69	FGFR2	0.35366590
70	IRAK1	0.33211101
71	STK11	0.32585508
72	PRKCQ	0.31053403
73	CAMK2A	0.30606940
74	PRKCE	0.29266119
75	PRKD1	0.28844001
76	ABL1	0.28752527
77	NTRK3	0.28707407
78	KSR2	0.27267720
79	PRKACA	0.26176674
80	CSNK1G1	0.26007420
81	TLK1	0.25575217
82	TIE1	0.24418550
83	SYK	0.24004465
84	RPS6KA5	0.22518183
85	PRKCI	0.22162549
86	IRAK3	0.21248744
87	PRKCG	0.18288873
88	INSRR	0.18198575
89	CHUK	0.17875070
90	MAPK3	0.17074552
91	PTK2B	0.16746686
92	PLK1	0.16578196
93	PRKCZ	0.15674512
94	CAMK2B	0.15270176
95	PIM2	0.14091583
96	CDC7	0.13719680
97	PKN1	0.12460074
98	NEK9	0.11405923
99	PRKACB	0.11331619
100	MYLK	0.11071514

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	4.90056736
2	Phototransduction_Homo sapiens_hsa04744	4.82817147
3	Fatty acid biosynthesis_Homo sapiens_hsa00061	3.28018892
4	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	3.26170557
5	Nicotine addiction_Homo sapiens_hsa05033	3.10610324
6	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.42488776
7	Nitrogen metabolism_Homo sapiens_hsa00910	2.24660919
8	Basal transcription factors_Homo sapiens_hsa03022	2.19439151
9	Taste transduction_Homo sapiens_hsa04742	2.15711566
10	Butanoate metabolism_Homo sapiens_hsa00650	2.14168585
11	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	2.08450623
12	Sphingolipid metabolism_Homo sapiens_hsa00600	2.04070659
13	Olfactory transduction_Homo sapiens_hsa04740	2.01446008
14	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.01233975
15	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.92643700
16	Morphine addiction_Homo sapiens_hsa05032	1.84771110
17	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.78147195
18	Tryptophan metabolism_Homo sapiens_hsa00380	1.74926520
19	Phenylalanine metabolism_Homo sapiens_hsa00360	1.70187894
20	One carbon pool by folate_Homo sapiens_hsa00670	1.69751752
21	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.62225579
22	Linoleic acid metabolism_Homo sapiens_hsa00591	1.62154342
23	Sulfur metabolism_Homo sapiens_hsa00920	1.58755985
24	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.51167543
25	Homologous recombination_Homo sapiens_hsa03440	1.50928932
26	ABC transporters_Homo sapiens_hsa02010	1.41787339
27	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.38749589
28	Glutamatergic synapse_Homo sapiens_hsa04724	1.36387362
29	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.29731835
30	GABAergic synapse_Homo sapiens_hsa04727	1.29684736
31	Calcium signaling pathway_Homo sapiens_hsa04020	1.28135425
32	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.17759765
33	Histidine metabolism_Homo sapiens_hsa00340	1.17342260
34	Collecting duct acid secretion_Homo sapiens_hsa04966	1.09144663
35	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.08570640
36	Serotonergic synapse_Homo sapiens_hsa04726	1.06405255
37	Sulfur relay system_Homo sapiens_hsa04122	1.04279892
38	beta-Alanine metabolism_Homo sapiens_hsa00410	1.03126543
39	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.95294874
40	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.93572946
41	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.90584355
42	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.89546959
43	Tyrosine metabolism_Homo sapiens_hsa00350	0.86077967
44	Primary immunodeficiency_Homo sapiens_hsa05340	0.86065481
45	Bile secretion_Homo sapiens_hsa04976	0.79832078
46	Selenocompound metabolism_Homo sapiens_hsa00450	0.79592755
47	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.76473865
48	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.76082402
49	Fatty acid metabolism_Homo sapiens_hsa01212	0.74448706
50	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.73366481
51	Circadian entrainment_Homo sapiens_hsa04713	0.71495328
52	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.69710305
53	Peroxisome_Homo sapiens_hsa04146	0.69383151
54	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.69110039
55	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.68152175
56	Caffeine metabolism_Homo sapiens_hsa00232	0.67449430
57	Viral myocarditis_Homo sapiens_hsa05416	0.63186908
58	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.62856960
59	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.60245931
60	Long-term depression_Homo sapiens_hsa04730	0.60016898
61	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.59542690
62	Fatty acid degradation_Homo sapiens_hsa00071	0.59472322
63	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.59026257
64	Ether lipid metabolism_Homo sapiens_hsa00565	0.58270807
65	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.56720330
66	Lysine degradation_Homo sapiens_hsa00310	0.54751321
67	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.54721120
68	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.54106875
69	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.53402731
70	RNA polymerase_Homo sapiens_hsa03020	0.52877549
71	Fanconi anemia pathway_Homo sapiens_hsa03460	0.51116526
72	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.49776089
73	Salivary secretion_Homo sapiens_hsa04970	0.48003030
74	Gastric acid secretion_Homo sapiens_hsa04971	0.46806049
75	RNA degradation_Homo sapiens_hsa03018	0.44845661
76	Chemical carcinogenesis_Homo sapiens_hsa05204	0.43346247
77	Glycerolipid metabolism_Homo sapiens_hsa00561	0.42351746
78	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.40463889
79	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.39715528
80	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.39506274
81	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.39471869
82	Platelet activation_Homo sapiens_hsa04611	0.39049497
83	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.38693764
84	Oxidative phosphorylation_Homo sapiens_hsa00190	0.38322633
85	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.37031667
86	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.36727219
87	cAMP signaling pathway_Homo sapiens_hsa04024	0.35131784
88	Asthma_Homo sapiens_hsa05310	0.33692285
89	Purine metabolism_Homo sapiens_hsa00230	0.32698104
90	Retinol metabolism_Homo sapiens_hsa00830	0.31904429
91	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.28620466
92	Cholinergic synapse_Homo sapiens_hsa04725	0.27129474
93	Fatty acid elongation_Homo sapiens_hsa00062	0.26906878
94	Propanoate metabolism_Homo sapiens_hsa00640	0.26815410
95	Metabolic pathways_Homo sapiens_hsa01100	0.26713237
96	ECM-receptor interaction_Homo sapiens_hsa04512	0.26333559
97	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.25855615
98	PPAR signaling pathway_Homo sapiens_hsa03320	0.25269475
99	Regulation of autophagy_Homo sapiens_hsa04140	0.23759072
100	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.23576086

VN1R7P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »