VN1R81P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA double-strand break processing (GO:0000729)5.31372662
2kinetochore organization (GO:0051383)4.97535395
3limb bud formation (GO:0060174)4.90093976
4somatic diversification of immune receptors via somatic mutation (GO:0002566)4.55638675
5somatic hypermutation of immunoglobulin genes (GO:0016446)4.55638675
6presynaptic membrane assembly (GO:0097105)4.37786364
7kinetochore assembly (GO:0051382)4.29037616
8negative regulation of DNA-dependent DNA replication (GO:2000104)4.28338366
9chromatin remodeling at centromere (GO:0031055)4.27261990
10sister chromatid segregation (GO:0000819)4.18783077
11resolution of meiotic recombination intermediates (GO:0000712)4.16461525
12protein localization to kinetochore (GO:0034501)4.11043384
13CENP-A containing nucleosome assembly (GO:0034080)4.02217873
14mitotic sister chromatid segregation (GO:0000070)3.92236156
15regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.86263426
16protein K6-linked ubiquitination (GO:0085020)3.85998481
17replication fork processing (GO:0031297)3.81499475
18regulation of DNA endoreduplication (GO:0032875)3.81000163
19histone exchange (GO:0043486)3.72102199
20mitotic sister chromatid cohesion (GO:0007064)3.67462855
21metaphase plate congression (GO:0051310)3.67180024
22synapsis (GO:0007129)3.63566800
23presynaptic membrane organization (GO:0097090)3.61316042
24non-recombinational repair (GO:0000726)3.60980230
25double-strand break repair via nonhomologous end joining (GO:0006303)3.60980230
26maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.59029628
27meiotic chromosome segregation (GO:0045132)3.58785533
28DNA replication-dependent nucleosome assembly (GO:0006335)3.56203709
29DNA replication-dependent nucleosome organization (GO:0034723)3.56203709
30spindle checkpoint (GO:0031577)3.51832005
31DNA catabolic process, exonucleolytic (GO:0000738)3.51553785
32mitotic metaphase plate congression (GO:0007080)3.47225970
33intra-S DNA damage checkpoint (GO:0031573)3.45086633
34DNA replication-independent nucleosome assembly (GO:0006336)3.39873890
35DNA replication-independent nucleosome organization (GO:0034724)3.39873890
36centriole replication (GO:0007099)3.36941083
37nuclear pore complex assembly (GO:0051292)3.35336259
38mitotic nuclear envelope disassembly (GO:0007077)3.33068318
39mitotic spindle checkpoint (GO:0071174)3.32593770
40regulation of mitotic spindle checkpoint (GO:1903504)3.26118813
41regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.26118813
42nuclear pore organization (GO:0006999)3.25315620
43DNA replication checkpoint (GO:0000076)3.23273076
44mitotic recombination (GO:0006312)3.22588811
45DNA ligation (GO:0006266)3.20657856
46protein localization to chromosome, centromeric region (GO:0071459)3.15336007
47telomere maintenance via semi-conservative replication (GO:0032201)3.14958843
48establishment of chromosome localization (GO:0051303)3.14886313
49DNA strand elongation involved in DNA replication (GO:0006271)3.14355463
50mitotic G2/M transition checkpoint (GO:0044818)3.13706361
51attachment of spindle microtubules to kinetochore (GO:0008608)3.12184939
52negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.10192612
53DNA topological change (GO:0006265)3.09277956
54regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.08678367
55regulation of mitotic metaphase/anaphase transition (GO:0030071)3.08678367
56negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.06613312
57negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.06613312
58negative regulation of mitotic sister chromatid segregation (GO:0033048)3.06613312
59negative regulation of mitotic sister chromatid separation (GO:2000816)3.06613312
60negative regulation of sister chromatid segregation (GO:0033046)3.06613312
61histone H2A acetylation (GO:0043968)3.06546817
62postreplication repair (GO:0006301)3.04844011
63nucleotide-excision repair, DNA gap filling (GO:0006297)3.04408874
64sympathetic nervous system development (GO:0048485)3.04159440
65postsynaptic membrane organization (GO:0001941)3.03824274
66recombinational repair (GO:0000725)3.02254970
67spindle assembly checkpoint (GO:0071173)3.01900755
68negative regulation of chromosome segregation (GO:0051985)3.01362797
69mitotic spindle assembly checkpoint (GO:0007094)3.01041714
70negative regulation of DNA recombination (GO:0045910)3.00628316
71nuclear envelope disassembly (GO:0051081)3.00452356
72membrane disassembly (GO:0030397)3.00452356
73double-strand break repair via homologous recombination (GO:0000724)2.98890740
74regulation of sister chromatid segregation (GO:0033045)2.98197831
75regulation of mitotic sister chromatid separation (GO:0010965)2.98197831
76regulation of mitotic sister chromatid segregation (GO:0033047)2.98197831
77DNA strand elongation (GO:0022616)2.97026869
78positive regulation of cell cycle checkpoint (GO:1901978)2.96890482
79neural tube formation (GO:0001841)2.96182225
80mitotic G2 DNA damage checkpoint (GO:0007095)2.92676991
81response to pheromone (GO:0019236)2.91994801
82chromosome segregation (GO:0007059)2.90316047
83regulation of chromosome segregation (GO:0051983)2.90236334
84somite development (GO:0061053)2.89242128
85positive regulation of dendritic spine morphogenesis (GO:0061003)2.86880742
86regulation of centriole replication (GO:0046599)2.85564644
87ventricular cardiac muscle cell development (GO:0055015)2.85008116
88telomere maintenance via recombination (GO:0000722)2.84709326
89lactate metabolic process (GO:0006089)2.82250628
90peptidyl-histidine modification (GO:0018202)2.81408465
91DNA damage response, detection of DNA damage (GO:0042769)2.78786392
92glial cell proliferation (GO:0014009)2.77878527
93positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.76950739
94positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.76950739
95positive regulation of mitotic sister chromatid separation (GO:1901970)2.76950739
96centrosome duplication (GO:0051298)2.71782086
97somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.71432253
98isotype switching (GO:0045190)2.71432253
99somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.71432253
100mitotic chromosome condensation (GO:0007076)2.70600687

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.05949264
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.98336481
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.84375386
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.54944669
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.44263808
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.12728114
7MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.78455682
8ZNF274_21170338_ChIP-Seq_K562_Hela2.62411600
9CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.54926807
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.52264633
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.49358152
12RBPJ_22232070_ChIP-Seq_NCS_Mouse2.39887170
13FUS_26573619_Chip-Seq_HEK293_Human2.32853923
14EWS_26573619_Chip-Seq_HEK293_Human2.27422469
15AR_21909140_ChIP-Seq_LNCAP_Human2.26544515
16KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.24459866
17POU3F2_20337985_ChIP-ChIP_501MEL_Human2.23369089
18GBX2_23144817_ChIP-Seq_PC3_Human2.20376467
19VDR_22108803_ChIP-Seq_LS180_Human2.15607452
20IGF1R_20145208_ChIP-Seq_DFB_Human2.10317564
21ZFP57_27257070_Chip-Seq_ESCs_Mouse2.05115632
22EST1_17652178_ChIP-ChIP_JURKAT_Human1.98337640
23PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.93419054
24ELK1_19687146_ChIP-ChIP_HELA_Human1.90708985
25CTBP2_25329375_ChIP-Seq_LNCAP_Human1.88883345
26HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.83156780
27GABP_17652178_ChIP-ChIP_JURKAT_Human1.81378443
28P300_19829295_ChIP-Seq_ESCs_Human1.80395077
29TP63_19390658_ChIP-ChIP_HaCaT_Human1.80016764
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.74024324
31POU5F1_16153702_ChIP-ChIP_HESCs_Human1.70087901
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.61427396
33AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.60390746
34E2F1_21310950_ChIP-Seq_MCF-7_Human1.56433336
35TAF15_26573619_Chip-Seq_HEK293_Human1.53729797
36CREB1_15753290_ChIP-ChIP_HEK293T_Human1.49927834
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.48178063
38CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.47999505
39PADI4_21655091_ChIP-ChIP_MCF-7_Human1.47848672
40SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.46756038
41SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41848233
42MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.41427976
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.39543841
44YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.37685774
45OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35583500
46FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.31619557
47GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.31341409
48UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.29330469
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.26963702
50MYC_18940864_ChIP-ChIP_HL60_Human1.26683258
51FLI1_27457419_Chip-Seq_LIVER_Mouse1.26331063
52WT1_19549856_ChIP-ChIP_CCG9911_Human1.25319445
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.24863310
54SMAD4_21799915_ChIP-Seq_A2780_Human1.22435549
55MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.21718878
56SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20036622
57FOXP3_21729870_ChIP-Seq_TREG_Human1.18553690
58SOX9_26525672_Chip-Seq_HEART_Mouse1.18438661
59SOX2_16153702_ChIP-ChIP_HESCs_Human1.17795849
60ER_23166858_ChIP-Seq_MCF-7_Human1.16046155
61HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.14850055
62RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.14303409
63BCAT_22108803_ChIP-Seq_LS180_Human1.13229817
64MYCN_18555785_ChIP-Seq_MESCs_Mouse1.10688893
65TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09424794
66TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08852330
67IRF1_19129219_ChIP-ChIP_H3396_Human1.08678316
68EZH2_27294783_Chip-Seq_NPCs_Mouse1.07293424
69NANOG_16153702_ChIP-ChIP_HESCs_Human1.07095682
70GATA1_26923725_Chip-Seq_HPCs_Mouse1.06740083
71STAT3_23295773_ChIP-Seq_U87_Human1.06679957
72NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.06641219
73DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.04747675
74TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.03955161
75AR_25329375_ChIP-Seq_VCAP_Human1.01330992
76KLF5_20875108_ChIP-Seq_MESCs_Mouse1.01284694
77VDR_23849224_ChIP-Seq_CD4+_Human1.01242109
78PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.98572867
79GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.98225722
80EZH2_22144423_ChIP-Seq_EOC_Human0.98065083
81NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.98018311
82MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.96238272
83JUN_21703547_ChIP-Seq_K562_Human0.95607367
84TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.94799220
85PCGF2_27294783_Chip-Seq_ESCs_Mouse0.93503539
86TBX3_20139965_ChIP-Seq_ESCs_Mouse0.93200917
87ETS1_20019798_ChIP-Seq_JURKAT_Human0.92004153
88TBX3_20139965_ChIP-Seq_MESCs_Mouse0.91988328
89NANOG_18555785_Chip-Seq_ESCs_Mouse0.91754036
90STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.90334732
91HOXB4_20404135_ChIP-ChIP_EML_Mouse0.89503553
92SUZ12_27294783_Chip-Seq_NPCs_Mouse0.89472216
93TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89128707
94POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.89128707
95TCF4_23295773_ChIP-Seq_U87_Human0.88846364
96NOTCH1_21737748_ChIP-Seq_TLL_Human0.87637037
97CBP_20019798_ChIP-Seq_JUKART_Human0.87483556
98IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.87483556
99RUNX2_22187159_ChIP-Seq_PCA_Human0.87351744
100SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.87345930

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability3.97834417
2MP0002102_abnormal_ear_morphology3.76250218
3MP0008058_abnormal_DNA_repair3.67365515
4MP0008057_abnormal_DNA_replication3.12552401
5MP0000372_irregular_coat_pigmentation2.64147730
6MP0003111_abnormal_nucleus_morphology2.55572436
7MP0008877_abnormal_DNA_methylation2.43247633
8MP0002234_abnormal_pharynx_morphology2.35283284
9MP0001529_abnormal_vocalization2.28889068
10MP0003693_abnormal_embryo_hatching2.12295132
11MP0003077_abnormal_cell_cycle2.07574001
12MP0003718_maternal_effect1.84444968
13MP0001293_anophthalmia1.83044837
14MP0003937_abnormal_limbs/digits/tail_de1.78240228
15MP0003890_abnormal_embryonic-extraembry1.76027588
16MP0001984_abnormal_olfaction1.75738355
17MP0004957_abnormal_blastocyst_morpholog1.75415154
18MP0003283_abnormal_digestive_organ1.73789253
19MP0002751_abnormal_autonomic_nervous1.73640119
20MP0010307_abnormal_tumor_latency1.71725241
21MP0009697_abnormal_copulation1.71489965
22MP0000778_abnormal_nervous_system1.64723171
23MP0002938_white_spotting1.60068421
24MP0003119_abnormal_digestive_system1.59700694
25MP0005171_absent_coat_pigmentation1.59529513
26MP0003786_premature_aging1.58628044
27MP0008789_abnormal_olfactory_epithelium1.57886116
28MP0008932_abnormal_embryonic_tissue1.57579421
29MP0006292_abnormal_olfactory_placode1.53704968
30MP0002736_abnormal_nociception_after1.49599334
31MP0002233_abnormal_nose_morphology1.47530604
32MP0005367_renal/urinary_system_phenotyp1.47256426
33MP0000516_abnormal_urinary_system1.47256426
34MP0003880_abnormal_central_pattern1.45854108
35MP0003121_genomic_imprinting1.45272583
36MP0003567_abnormal_fetal_cardiomyocyte1.40082339
37MP0006072_abnormal_retinal_apoptosis1.37178995
38MP0005248_abnormal_Harderian_gland1.37174450
39MP0003136_yellow_coat_color1.31643107
40MP0003787_abnormal_imprinting1.31317824
41MP0001286_abnormal_eye_development1.28006162
42MP0005646_abnormal_pituitary_gland1.27471282
43MP0008007_abnormal_cellular_replicative1.26174957
44MP0006054_spinal_hemorrhage1.24116270
45MP0005499_abnormal_olfactory_system1.23920715
46MP0005394_taste/olfaction_phenotype1.23920715
47MP0000569_abnormal_digit_pigmentation1.22968942
48MP0000537_abnormal_urethra_morphology1.21738845
49MP0009053_abnormal_anal_canal1.18591921
50MP0003755_abnormal_palate_morphology1.17855436
51MP0005408_hypopigmentation1.16256201
52MP0005075_abnormal_melanosome_morpholog1.13311806
53MP0004742_abnormal_vestibular_system1.12290217
54MP0003938_abnormal_ear_development1.09586208
55MP0003861_abnormal_nervous_system1.07865170
56MP0002697_abnormal_eye_size1.07543198
57MP0003935_abnormal_craniofacial_develop1.06779109
58MP0008995_early_reproductive_senescence1.06389444
59MP0003941_abnormal_skin_development1.04421399
60MP0002822_catalepsy1.03522797
61MP0001324_abnormal_eye_pigmentation1.03313382
62MP0001929_abnormal_gametogenesis1.02473283
63MP0002095_abnormal_skin_pigmentation1.02148868
64MP0002210_abnormal_sex_determination1.02120829
65MP0010030_abnormal_orbit_morphology1.01582971
66MP0003385_abnormal_body_wall1.01430608
67MP0002084_abnormal_developmental_patter1.01306259
68MP0001177_atelectasis1.01170719
69MP0002282_abnormal_trachea_morphology1.00439463
70MP0005253_abnormal_eye_physiology0.99930386
71MP0001486_abnormal_startle_reflex0.99824406
72MP0000631_abnormal_neuroendocrine_gland0.98668802
73MP0004924_abnormal_behavior0.96357669
74MP0005386_behavior/neurological_phenoty0.96357669
75MP0000383_abnormal_hair_follicle0.96213653
76MP0001697_abnormal_embryo_size0.96056123
77MP0004197_abnormal_fetal_growth/weight/0.94045698
78MP0002085_abnormal_embryonic_tissue0.93476501
79MP0002735_abnormal_chemical_nociception0.92720035
80MP0001968_abnormal_touch/_nociception0.92535660
81MP0001188_hyperpigmentation0.92018968
82MP0005391_vision/eye_phenotype0.91954451
83MP0005551_abnormal_eye_electrophysiolog0.91400672
84MP0001119_abnormal_female_reproductive0.91184410
85MP0005174_abnormal_tail_pigmentation0.90706824
86MP0000647_abnormal_sebaceous_gland0.89738428
87MP0000015_abnormal_ear_pigmentation0.89554510
88MP0002396_abnormal_hematopoietic_system0.88002429
89MP0000427_abnormal_hair_cycle0.87702228
90MP0010352_gastrointestinal_tract_polyps0.87255102
91MP0000653_abnormal_sex_gland0.86273121
92MP0002653_abnormal_ependyma_morphology0.85968489
93MP0001346_abnormal_lacrimal_gland0.85401802
94MP0009703_decreased_birth_body0.84393837
95MP0003698_abnormal_male_reproductive0.83820267
96MP0001145_abnormal_male_reproductive0.82648013
97MP0001672_abnormal_embryogenesis/_devel0.81674594
98MP0005380_embryogenesis_phenotype0.81674594
99MP0002092_abnormal_eye_morphology0.81448699
100MP0002163_abnormal_gland_morphology0.80513608

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)4.06079208
2Abnormality of the astrocytes (HP:0100707)4.03597656
3Astrocytoma (HP:0009592)4.03597656
4Abnormality of the labia minora (HP:0012880)3.68580471
5Glioma (HP:0009733)3.68503037
6Volvulus (HP:0002580)3.65989582
7Rhabdomyosarcoma (HP:0002859)3.48745114
8Abnormal lung lobation (HP:0002101)3.44866507
9Abnormality of chromosome stability (HP:0003220)3.28841085
10Aplasia/Hypoplasia of the uvula (HP:0010293)3.16198402
11Abnormality of the ileum (HP:0001549)3.06149800
12Meckel diverticulum (HP:0002245)3.05989097
13Chromosomal breakage induced by crosslinking agents (HP:0003221)3.01522999
14Duodenal stenosis (HP:0100867)2.97346786
15Small intestinal stenosis (HP:0012848)2.97346786
16Colon cancer (HP:0003003)2.96416495
17Long clavicles (HP:0000890)2.91081441
18Hepatoblastoma (HP:0002884)2.82178543
19Nephroblastoma (Wilms tumor) (HP:0002667)2.80224381
20Abnormality of the duodenum (HP:0002246)2.72421103
21Abnormality of the preputium (HP:0100587)2.71686498
22Embryonal renal neoplasm (HP:0011794)2.71474218
23Aqueductal stenosis (HP:0002410)2.67854148
24Intestinal atresia (HP:0011100)2.67746279
25Neoplasm of the adrenal cortex (HP:0100641)2.67387959
26Medulloblastoma (HP:0002885)2.67260909
27Chromsome breakage (HP:0040012)2.66844762
28Cortical dysplasia (HP:0002539)2.60869981
29Neoplasm of striated muscle (HP:0009728)2.58123304
30Sloping forehead (HP:0000340)2.56162381
31Agnosia (HP:0010524)2.54212480
32Drooling (HP:0002307)2.49172934
33High anterior hairline (HP:0009890)2.39215408
34Hyperventilation (HP:0002883)2.37027081
35Pancreatic fibrosis (HP:0100732)2.29661490
36Bifid tongue (HP:0010297)2.26644602
37Amyotrophic lateral sclerosis (HP:0007354)2.22934009
38Excessive salivation (HP:0003781)2.21883562
39Biliary tract neoplasm (HP:0100574)2.19270426
40True hermaphroditism (HP:0010459)2.18310229
41Hypoplastic pelvis (HP:0008839)2.18266115
42Pancreatic cysts (HP:0001737)2.15091555
43Neoplasm of the colon (HP:0100273)2.10271923
44Embryonal neoplasm (HP:0002898)2.07737677
45Abnormality of chromosome segregation (HP:0002916)2.07598440
46Ectopic kidney (HP:0000086)2.07435453
47Abnormality of the lower motor neuron (HP:0002366)2.02191371
48Dandy-Walker malformation (HP:0001305)2.01981099
49Abnormality of midbrain morphology (HP:0002418)2.01768666
50Molar tooth sign on MRI (HP:0002419)2.01768666
51Facial hemangioma (HP:0000329)2.01754297
52Neoplasm of the oral cavity (HP:0100649)1.98005446
53Abnormal auditory evoked potentials (HP:0006958)1.97629957
54Aplasia/Hypoplasia of the sternum (HP:0006714)1.96487384
55Tented upper lip vermilion (HP:0010804)1.95616763
56Increased nuchal translucency (HP:0010880)1.94719560
57Triphalangeal thumb (HP:0001199)1.92128035
58Preaxial hand polydactyly (HP:0001177)1.91745075
59Myelodysplasia (HP:0002863)1.91387401
60Cafe-au-lait spot (HP:0000957)1.91193397
61Clubbing of toes (HP:0100760)1.91172371
62Megalencephaly (HP:0001355)1.91098282
63Neoplasm of the adrenal gland (HP:0100631)1.90179971
64Benign neoplasm of the central nervous system (HP:0100835)1.88101214
65Abnormality of the fetal cardiovascular system (HP:0010948)1.87927280
66Abnormal umbilical cord blood vessels (HP:0011403)1.87927280
67Single umbilical artery (HP:0001195)1.87927280
68Narrow forehead (HP:0000341)1.87568023
69Renal hypoplasia (HP:0000089)1.87153037
70Birth length less than 3rd percentile (HP:0003561)1.87088393
71Neoplasm of the small intestine (HP:0100833)1.86432683
72Pancreatic islet-cell hyperplasia (HP:0004510)1.86356537
73Asplenia (HP:0001746)1.84754717
74Anal atresia (HP:0002023)1.82788973
75Abnormality of the carotid arteries (HP:0005344)1.82372759
76Chronic hepatic failure (HP:0100626)1.79351839
77Cupped ear (HP:0000378)1.77180805
78Scrotal hypoplasia (HP:0000046)1.75778710
79Aplasia/Hypoplasia of the spleen (HP:0010451)1.75745084
80Ovarian neoplasm (HP:0100615)1.74019338
81Small hand (HP:0200055)1.72832086
82Intestinal polyposis (HP:0200008)1.72214191
83Breast carcinoma (HP:0003002)1.70313777
84Abnormal biliary tract morphology (HP:0012440)1.67484146
85Astigmatism (HP:0000483)1.66619210
86Nephronophthisis (HP:0000090)1.64726026
87Arteriovenous malformation (HP:0100026)1.64691025
88Neoplasm of the liver (HP:0002896)1.63671769
89Aplasia/Hypoplasia of the tongue (HP:0010295)1.63602546
90Patellar aplasia (HP:0006443)1.63278840
91Postaxial foot polydactyly (HP:0001830)1.62817451
92Lissencephaly (HP:0001339)1.62621239
93Gastrointestinal atresia (HP:0002589)1.61482501
94Meningioma (HP:0002858)1.60524896
95Choanal atresia (HP:0000453)1.60497913
96Retinal dysplasia (HP:0007973)1.59456490
97Intestinal polyp (HP:0005266)1.59078554
98Abnormality of the parathyroid morphology (HP:0011766)1.58764843
99Abnormality of the metopic suture (HP:0005556)1.56991118
100Supernumerary spleens (HP:0009799)1.55786334

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE13.77875854
2TRIM283.40629336
3WNK33.01820667
4MAP4K22.70572128
5PLK42.70373515
6MKNK22.53855682
7CCNB12.51509918
8BUB12.42313076
9FRK2.38663114
10CDC72.33707364
11TTK2.33369384
12SRPK12.18603412
13BRSK22.15181494
14PLK32.14184618
15NEK12.11671252
16TNIK2.10585793
17BCR2.09962806
18EIF2AK32.09405383
19MAP3K42.02614314
20EIF2AK11.96628928
21MKNK11.92546330
22PNCK1.89404873
23NUAK11.86727996
24MAPK131.77607235
25SIK31.76138233
26PBK1.58386591
27ERBB31.58125850
28ZAK1.49148523
29PLK21.45351225
30TSSK61.42521713
31PLK11.41255176
32PRKD31.40348945
33BMPR1B1.37899246
34ACVR1B1.36956645
35STK31.23728295
36BRSK11.16857834
37CASK1.15595688
38FGFR21.14685799
39MARK11.13656417
40ATR1.12121118
41EIF2AK21.08170335
42PAK31.05081728
43STK391.00520962
44PINK11.00049100
45KSR10.89518385
46CSNK1G10.89081810
47CSNK1G20.86553970
48NEK20.85775268
49ATM0.85593891
50CHEK20.80837356
51LATS10.80197662
52EPHA40.78953077
53FGFR10.78754385
54EPHB20.77853669
55MINK10.76300983
56MAP2K70.72701995
57CSNK1G30.67465785
58VRK10.67159931
59AURKB0.62769087
60ERBB20.61476341
61TGFBR10.61164998
62PDK20.59333685
63CSNK1A1L0.58707116
64CDK30.58511821
65DYRK20.57486319
66CHEK10.57121875
67CDK70.56390998
68ERBB40.54881816
69PRKCG0.54459894
70TAF10.54096787
71WNK40.51210500
72CLK10.50566204
73YES10.50353508
74RPS6KA40.50052758
75CDK10.49563241
76PRKCE0.47607855
77MARK30.43031771
78MST40.42470665
79GRK10.42439768
80DYRK30.42367316
81NME10.40083440
82MAP3K100.38921591
83PKN10.38674915
84STK38L0.38240426
85NLK0.37932981
86OXSR10.36919680
87PRKDC0.36654903
88AKT30.36451588
89BRAF0.36300745
90CDK180.35176168
91CDK20.35003986
92CSNK2A10.33549715
93SGK20.33077007
94VRK20.30683382
95BRD40.30078543
96PASK0.29669300
97PRKCH0.29397455
98CSNK1D0.28409106
99MELK0.28256885
100FLT30.26170400

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034504.41392949
2Mismatch repair_Homo sapiens_hsa034304.03914932
3Fanconi anemia pathway_Homo sapiens_hsa034603.09384517
4DNA replication_Homo sapiens_hsa030303.08096355
5Homologous recombination_Homo sapiens_hsa034403.06908658
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.61565829
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.54952138
8Cell cycle_Homo sapiens_hsa041102.51515566
9Propanoate metabolism_Homo sapiens_hsa006402.36690972
10Base excision repair_Homo sapiens_hsa034102.16803127
11RNA transport_Homo sapiens_hsa030132.07427987
12Nucleotide excision repair_Homo sapiens_hsa034202.01716233
13Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.99471515
14Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.99391936
15Proteasome_Homo sapiens_hsa030501.98311262
16Fatty acid elongation_Homo sapiens_hsa000621.95310370
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.95307540
18Basal transcription factors_Homo sapiens_hsa030221.90567109
19Steroid biosynthesis_Homo sapiens_hsa001001.86293327
20Protein export_Homo sapiens_hsa030601.66554875
21Spliceosome_Homo sapiens_hsa030401.65005411
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.60415715
23One carbon pool by folate_Homo sapiens_hsa006701.52557509
24Oocyte meiosis_Homo sapiens_hsa041141.49856560
25RNA polymerase_Homo sapiens_hsa030201.47641501
26RNA degradation_Homo sapiens_hsa030181.43749076
27Nicotine addiction_Homo sapiens_hsa050331.36547513
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.32556908
29Fatty acid metabolism_Homo sapiens_hsa012121.26661633
30Butanoate metabolism_Homo sapiens_hsa006501.25747000
31Selenocompound metabolism_Homo sapiens_hsa004501.24351215
32Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.23147062
33Pyruvate metabolism_Homo sapiens_hsa006201.22140676
34Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.21205342
35p53 signaling pathway_Homo sapiens_hsa041151.20017211
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.14134633
37Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.13987257
38Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.11941015
39Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.10507063
40Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.05643231
41Purine metabolism_Homo sapiens_hsa002301.01128982
42mRNA surveillance pathway_Homo sapiens_hsa030150.95208481
43Pyrimidine metabolism_Homo sapiens_hsa002400.94149211
44Hedgehog signaling pathway_Homo sapiens_hsa043400.93417570
45Basal cell carcinoma_Homo sapiens_hsa052170.88898720
46Hippo signaling pathway_Homo sapiens_hsa043900.88178188
47Phototransduction_Homo sapiens_hsa047440.77725035
482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.74680191
49Wnt signaling pathway_Homo sapiens_hsa043100.73678571
50Fatty acid degradation_Homo sapiens_hsa000710.72911084
51Colorectal cancer_Homo sapiens_hsa052100.70762881
52Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68745955
53MicroRNAs in cancer_Homo sapiens_hsa052060.68649546
54Parkinsons disease_Homo sapiens_hsa050120.68388389
55Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.68286493
56TGF-beta signaling pathway_Homo sapiens_hsa043500.66450527
57Lysine degradation_Homo sapiens_hsa003100.65289622
58Vitamin B6 metabolism_Homo sapiens_hsa007500.64012594
59Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.63040229
60Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.59390808
61Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.58968218
62Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.57570745
63Biosynthesis of amino acids_Homo sapiens_hsa012300.53259490
64Taste transduction_Homo sapiens_hsa047420.51675680
65Amphetamine addiction_Homo sapiens_hsa050310.51091917
66Carbon metabolism_Homo sapiens_hsa012000.50787517
67Melanoma_Homo sapiens_hsa052180.50575496
68Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.50533639
69Dopaminergic synapse_Homo sapiens_hsa047280.49785850
70Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48506292
71Endometrial cancer_Homo sapiens_hsa052130.47892631
72Prostate cancer_Homo sapiens_hsa052150.46634467
73Axon guidance_Homo sapiens_hsa043600.46596374
74Huntingtons disease_Homo sapiens_hsa050160.41949793
75Peroxisome_Homo sapiens_hsa041460.40422470
76Morphine addiction_Homo sapiens_hsa050320.39661036
77Adherens junction_Homo sapiens_hsa045200.38995967
78Metabolic pathways_Homo sapiens_hsa011000.37150623
79Gap junction_Homo sapiens_hsa045400.36827465
80Glutamatergic synapse_Homo sapiens_hsa047240.36014260
81Melanogenesis_Homo sapiens_hsa049160.34809109
82Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.33867355
83Ether lipid metabolism_Homo sapiens_hsa005650.33866055
84GABAergic synapse_Homo sapiens_hsa047270.33360095
85Caffeine metabolism_Homo sapiens_hsa002320.31948677
86Tryptophan metabolism_Homo sapiens_hsa003800.30625667
87Glioma_Homo sapiens_hsa052140.29638424
88Folate biosynthesis_Homo sapiens_hsa007900.29222453
89Tight junction_Homo sapiens_hsa045300.27992609
90Alcoholism_Homo sapiens_hsa050340.27514290
91N-Glycan biosynthesis_Homo sapiens_hsa005100.26853270
92Circadian entrainment_Homo sapiens_hsa047130.24460949
93Olfactory transduction_Homo sapiens_hsa047400.23829366
94Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.21383451
95Cocaine addiction_Homo sapiens_hsa050300.21101936
96Oxidative phosphorylation_Homo sapiens_hsa001900.20955222
97Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.19992975
98Glutathione metabolism_Homo sapiens_hsa004800.18632434
99Long-term depression_Homo sapiens_hsa047300.18467310
100Retinol metabolism_Homo sapiens_hsa008300.17759532

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