VN1R82P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein K6-linked ubiquitination (GO:0085020)5.37001553
2ubiquinone biosynthetic process (GO:0006744)4.66489551
3kinetochore organization (GO:0051383)4.62314855
4ubiquinone metabolic process (GO:0006743)4.61311634
5intraciliary transport (GO:0042073)4.29384853
6DNA double-strand break processing (GO:0000729)4.26538389
7kinetochore assembly (GO:0051382)4.23789603
8meiotic chromosome segregation (GO:0045132)4.03948660
9somatic diversification of immune receptors via somatic mutation (GO:0002566)4.00664474
10somatic hypermutation of immunoglobulin genes (GO:0016446)4.00664474
11chromatin remodeling at centromere (GO:0031055)3.94701320
12CENP-A containing nucleosome assembly (GO:0034080)3.94118137
13metaphase plate congression (GO:0051310)3.87678028
14quinone biosynthetic process (GO:1901663)3.87436662
15microtubule depolymerization (GO:0007019)3.83702864
16sequestering of actin monomers (GO:0042989)3.79660544
17negative regulation of DNA-dependent DNA replication (GO:2000104)3.77029585
18centriole replication (GO:0007099)3.70269959
19mitotic metaphase plate congression (GO:0007080)3.70029221
20negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.58960164
21negative regulation of translation, ncRNA-mediated (GO:0040033)3.58960164
22regulation of translation, ncRNA-mediated (GO:0045974)3.58960164
23regulation of DNA endoreduplication (GO:0032875)3.58662844
24mismatch repair (GO:0006298)3.58526335
25mitotic sister chromatid cohesion (GO:0007064)3.58504028
26replication fork processing (GO:0031297)3.57138577
27isoprenoid biosynthetic process (GO:0008299)3.54115407
28proteasome assembly (GO:0043248)3.48918720
29protein K11-linked ubiquitination (GO:0070979)3.44374275
30behavioral response to nicotine (GO:0035095)3.42651592
31spermatid nucleus differentiation (GO:0007289)3.34275340
32respiratory chain complex IV assembly (GO:0008535)3.34050206
33regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.32691021
34regulation of mitotic spindle checkpoint (GO:1903504)3.32691021
35histone exchange (GO:0043486)3.31851617
36histone H2A acetylation (GO:0043968)3.30555863
37DNA ligation (GO:0006266)3.30062007
38DNA replication-dependent nucleosome assembly (GO:0006335)3.29424216
39DNA replication-dependent nucleosome organization (GO:0034723)3.29424216
40nucleotide-excision repair, DNA gap filling (GO:0006297)3.29098540
41regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.27857255
42mitochondrial respiratory chain complex I assembly (GO:0032981)3.22191003
43NADH dehydrogenase complex assembly (GO:0010257)3.22191003
44mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.22191003
45resolution of meiotic recombination intermediates (GO:0000712)3.21165228
46protein complex biogenesis (GO:0070271)3.17890308
47spindle assembly involved in mitosis (GO:0090307)3.16840840
48microtubule anchoring (GO:0034453)3.13215363
49DNA replication-independent nucleosome assembly (GO:0006336)3.12534248
50DNA replication-independent nucleosome organization (GO:0034724)3.12534248
51regulation of spindle organization (GO:0090224)3.12058573
52DNA catabolic process, exonucleolytic (GO:0000738)3.11433523
53piRNA metabolic process (GO:0034587)3.09755281
54proline transport (GO:0015824)3.09582466
55microtubule polymerization or depolymerization (GO:0031109)3.08902626
56protein localization to chromosome (GO:0034502)3.06565223
57spindle checkpoint (GO:0031577)3.05972133
58presynaptic membrane assembly (GO:0097105)3.05624584
59mitotic sister chromatid segregation (GO:0000070)2.98191957
60generation of neurons (GO:0048699)2.96777484
61microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.94889917
62mitotic spindle checkpoint (GO:0071174)2.94189467
63regulation of centriole replication (GO:0046599)2.94183281
64telomere maintenance via semi-conservative replication (GO:0032201)2.93547693
65sister chromatid segregation (GO:0000819)2.92353196
66attachment of spindle microtubules to kinetochore (GO:0008608)2.91071162
67DNA damage response, detection of DNA damage (GO:0042769)2.88089534
68retinal ganglion cell axon guidance (GO:0031290)2.87050491
69regulation of helicase activity (GO:0051095)2.85254798
70centrosome organization (GO:0051297)2.85217368
71negative regulation of mitotic sister chromatid separation (GO:2000816)2.85092224
72negative regulation of sister chromatid segregation (GO:0033046)2.85092224
73negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.85092224
74negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.85092224
75negative regulation of mitotic sister chromatid segregation (GO:0033048)2.85092224
76cholesterol biosynthetic process (GO:0006695)2.84800067
77protein sumoylation (GO:0016925)2.84694605
78regulation of double-strand break repair via homologous recombination (GO:0010569)2.84561071
79retinal rod cell development (GO:0046548)2.84386692
80regulation of mRNA 3-end processing (GO:0031440)2.79111894
81negative regulation of mRNA processing (GO:0050686)2.78680023
82establishment of chromosome localization (GO:0051303)2.76690250
83protein neddylation (GO:0045116)2.75412863
84negative regulation of chromosome segregation (GO:0051985)2.74922450
85spindle assembly checkpoint (GO:0071173)2.74466010
86cytochrome complex assembly (GO:0017004)2.74427336
87regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.74136298
88regulation of mitotic metaphase/anaphase transition (GO:0030071)2.74136298
89negative regulation of DNA recombination (GO:0045910)2.73435930
90mitotic spindle assembly checkpoint (GO:0007094)2.73169654
91mitochondrial respiratory chain complex assembly (GO:0033108)2.72814758
92L-fucose catabolic process (GO:0042355)2.71998893
93fucose catabolic process (GO:0019317)2.71998893
94L-fucose metabolic process (GO:0042354)2.71998893
95olfactory bulb development (GO:0021772)2.71397378
96regulation of nuclear cell cycle DNA replication (GO:0033262)2.71293659
97maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.71059538
98DNA replication checkpoint (GO:0000076)2.69994369
99positive regulation of mitotic sister chromatid separation (GO:1901970)2.69878880
100positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.69878880

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.24361042
2E2F7_22180533_ChIP-Seq_HELA_Human3.82385932
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.57269818
4ZNF274_21170338_ChIP-Seq_K562_Hela3.51343226
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.48883690
6MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.33100687
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.18126442
8VDR_22108803_ChIP-Seq_LS180_Human3.09096433
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.98251759
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.64473190
11IGF1R_20145208_ChIP-Seq_DFB_Human2.62279562
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.62087473
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.55917992
14SALL1_21062744_ChIP-ChIP_HESCs_Human2.51724156
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.51045490
16POU3F2_20337985_ChIP-ChIP_501MEL_Human2.44014090
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.36752082
18ELK1_19687146_ChIP-ChIP_HELA_Human2.32184825
19EWS_26573619_Chip-Seq_HEK293_Human2.25544958
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.22564942
21TAF15_26573619_Chip-Seq_HEK293_Human2.22303206
22EZH2_22144423_ChIP-Seq_EOC_Human2.21377974
23HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.18309070
24FUS_26573619_Chip-Seq_HEK293_Human2.14183864
25NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.10954009
26PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.02417047
27CREB1_15753290_ChIP-ChIP_HEK293T_Human2.01435632
28TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.91235040
29IRF1_19129219_ChIP-ChIP_H3396_Human1.86797284
30ZFP57_27257070_Chip-Seq_ESCs_Mouse1.76118817
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.73702954
32MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.71322261
33VDR_23849224_ChIP-Seq_CD4+_Human1.70893218
34KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.69634851
35ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.69212087
36FLI1_27457419_Chip-Seq_LIVER_Mouse1.68615872
37P300_19829295_ChIP-Seq_ESCs_Human1.67433217
38JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.59176161
39PADI4_21655091_ChIP-ChIP_MCF-7_Human1.52296043
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.48787723
41FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.46059122
42AR_21909140_ChIP-Seq_LNCAP_Human1.44665921
43ELF1_17652178_ChIP-ChIP_JURKAT_Human1.42856277
44CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.42466659
45FOXP3_21729870_ChIP-Seq_TREG_Human1.41443502
46ETS1_20019798_ChIP-Seq_JURKAT_Human1.38560360
47YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36265155
48GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.33231974
49SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.33210706
50SRF_21415370_ChIP-Seq_HL-1_Mouse1.32301248
51MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.31687508
52CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.27760076
53MYC_18940864_ChIP-ChIP_HL60_Human1.27429812
54GABP_19822575_ChIP-Seq_HepG2_Human1.26636881
55SOX2_16153702_ChIP-ChIP_HESCs_Human1.26613158
56CBX2_27304074_Chip-Seq_ESCs_Mouse1.22399067
57GBX2_23144817_ChIP-Seq_PC3_Human1.21943828
58MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.21363756
59RNF2_27304074_Chip-Seq_NSC_Mouse1.20997711
60CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.18653388
61E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.17813067
62PCGF2_27294783_Chip-Seq_ESCs_Mouse1.16489439
63E2F1_21310950_ChIP-Seq_MCF-7_Human1.14264663
64AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.12376123
65POU5F1_16153702_ChIP-ChIP_HESCs_Human1.11661951
66TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10278175
67POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10278175
68MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.10151341
69RUNX2_22187159_ChIP-Seq_PCA_Human1.09635739
70KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08968134
71RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.07904399
72NOTCH1_21737748_ChIP-Seq_TLL_Human1.07592817
73NANOG_16153702_ChIP-ChIP_HESCs_Human1.07436859
74FOXA1_21572438_ChIP-Seq_LNCaP_Human1.05334923
75TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05246883
76HOXB4_20404135_ChIP-ChIP_EML_Mouse1.03148177
77UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02528841
78TP53_22573176_ChIP-Seq_HFKS_Human1.01045008
79SMAD4_21799915_ChIP-Seq_A2780_Human1.00172227
80LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99651715
81CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.99515418
82SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97521819
83EZH2_27294783_Chip-Seq_NPCs_Mouse0.97143111
84HTT_18923047_ChIP-ChIP_STHdh_Human0.95373082
85DCP1A_22483619_ChIP-Seq_HELA_Human0.94687526
86PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.93177872
87EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.91813924
88WT1_19549856_ChIP-ChIP_CCG9911_Human0.91745632
89ER_23166858_ChIP-Seq_MCF-7_Human0.91739919
90E2F1_18555785_ChIP-Seq_MESCs_Mouse0.90403436
91MYCN_18555785_ChIP-Seq_MESCs_Mouse0.89971507
92IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.89563955
93CBP_20019798_ChIP-Seq_JUKART_Human0.89563955
94STAT3_23295773_ChIP-Seq_U87_Human0.88895620
95PIAS1_25552417_ChIP-Seq_VCAP_Human0.88748652
96RBPJ_22232070_ChIP-Seq_NCS_Mouse0.87528175
97AUTS2_25519132_ChIP-Seq_293T-REX_Human0.87166581
98TTF2_22483619_ChIP-Seq_HELA_Human0.87101773
99PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.86890732
100TCF4_23295773_ChIP-Seq_U87_Human0.86876125

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation4.41587297
2MP0003787_abnormal_imprinting4.22944025
3MP0003693_abnormal_embryo_hatching3.47347289
4MP0010094_abnormal_chromosome_stability3.39982746
5MP0008058_abnormal_DNA_repair3.15562855
6MP0009697_abnormal_copulation2.99737406
7MP0000566_synostosis2.93299880
8MP0003121_genomic_imprinting2.62284614
9MP0003123_paternal_imprinting2.44644833
10MP0008789_abnormal_olfactory_epithelium2.11898417
11MP0003111_abnormal_nucleus_morphology2.11602427
12MP0006292_abnormal_olfactory_placode2.09599704
13MP0005084_abnormal_gallbladder_morpholo1.99161443
14MP0002163_abnormal_gland_morphology1.98762250
15MP0003119_abnormal_digestive_system1.95479939
16MP0000372_irregular_coat_pigmentation1.93964873
17MP0002938_white_spotting1.92269958
18MP0003567_abnormal_fetal_cardiomyocyte1.87793974
19MP0006276_abnormal_autonomic_nervous1.77067480
20MP0005253_abnormal_eye_physiology1.64443928
21MP0006072_abnormal_retinal_apoptosis1.61837432
22MP0001299_abnormal_eye_distance/1.60985672
23MP0002102_abnormal_ear_morphology1.60164346
24MP0005499_abnormal_olfactory_system1.56499019
25MP0005394_taste/olfaction_phenotype1.56499019
26MP0002653_abnormal_ependyma_morphology1.54725732
27MP0003718_maternal_effect1.53060025
28MP0002751_abnormal_autonomic_nervous1.53016794
29MP0001529_abnormal_vocalization1.50632098
30MP0004957_abnormal_blastocyst_morpholog1.50329702
31MP0002638_abnormal_pupillary_reflex1.49424208
32MP0004133_heterotaxia1.47783264
33MP0000647_abnormal_sebaceous_gland1.47449044
34MP0005379_endocrine/exocrine_gland_phen1.46601065
35MP0000778_abnormal_nervous_system1.40037759
36MP0005551_abnormal_eye_electrophysiolog1.37498393
37MP0003646_muscle_fatigue1.37453806
38MP0000631_abnormal_neuroendocrine_gland1.37115336
39MP0006054_spinal_hemorrhage1.35418640
40MP0008057_abnormal_DNA_replication1.33707316
41MP0008932_abnormal_embryonic_tissue1.32684075
42MP0003786_premature_aging1.28633890
43MP0002090_abnormal_vision1.26049732
44MP0003077_abnormal_cell_cycle1.25216973
45MP0001929_abnormal_gametogenesis1.24082277
46MP0001968_abnormal_touch/_nociception1.20489913
47MP0002210_abnormal_sex_determination1.18889109
48MP0003880_abnormal_central_pattern1.18463344
49MP0003937_abnormal_limbs/digits/tail_de1.18255967
50MP0005248_abnormal_Harderian_gland1.16171766
51MP0003385_abnormal_body_wall1.15994393
52MP0002160_abnormal_reproductive_system1.14005942
53MP0010030_abnormal_orbit_morphology1.13058623
54MP0001486_abnormal_startle_reflex1.08401529
55MP0001145_abnormal_male_reproductive1.06576986
56MP0003698_abnormal_male_reproductive1.05792764
57MP0003943_abnormal_hepatobiliary_system1.05703651
58MP0006035_abnormal_mitochondrial_morpho1.00944292
59MP0000653_abnormal_sex_gland1.00835029
60MP0002837_dystrophic_cardiac_calcinosis1.00825236
61MP0005646_abnormal_pituitary_gland1.00630840
62MP0001727_abnormal_embryo_implantation0.98793608
63MP0004215_abnormal_myocardial_fiber0.98544622
64MP0003122_maternal_imprinting0.97802976
65MP0001293_anophthalmia0.96637518
66MP0008995_early_reproductive_senescence0.95244429
67MP0005391_vision/eye_phenotype0.95016426
68MP0009046_muscle_twitch0.89431294
69MP0003195_calcinosis0.87676241
70MP0005195_abnormal_posterior_eye0.87662837
71MP0002233_abnormal_nose_morphology0.87638654
72MP0001286_abnormal_eye_development0.87403044
73MP0002928_abnormal_bile_duct0.86756787
74MP0004145_abnormal_muscle_electrophysio0.85503033
75MP0005423_abnormal_somatic_nervous0.84927249
76MP0001970_abnormal_pain_threshold0.83490672
77MP0002736_abnormal_nociception_after0.80321131
78MP0005389_reproductive_system_phenotype0.80015745
79MP0005645_abnormal_hypothalamus_physiol0.79876741
80MP0002272_abnormal_nervous_system0.78921550
81MP0003283_abnormal_digestive_organ0.78686009
82MP0002184_abnormal_innervation0.77360284
83MP0010678_abnormal_skin_adnexa0.74298139
84MP0001119_abnormal_female_reproductive0.73960389
85MP0004742_abnormal_vestibular_system0.73653375
86MP0003755_abnormal_palate_morphology0.73475848
87MP0006036_abnormal_mitochondrial_physio0.73092445
88MP0000383_abnormal_hair_follicle0.72289097
89MP0003861_abnormal_nervous_system0.72167913
90MP0004147_increased_porphyrin_level0.71571321
91MP0002557_abnormal_social/conspecific_i0.71370392
92MP0002572_abnormal_emotion/affect_behav0.69920641
93MP0003252_abnormal_bile_duct0.69250838
94MP0003137_abnormal_impulse_conducting0.68632263
95MP0002067_abnormal_sensory_capabilities0.68455654
96MP0002752_abnormal_somatic_nervous0.68285140
97MP0004085_abnormal_heartbeat0.68044067
98MP0002734_abnormal_mechanical_nocicepti0.67732716
99MP0003890_abnormal_embryonic-extraembry0.66776338
100MP0009745_abnormal_behavioral_response0.66771760

Predicted human phenotypes

RankGene SetZ-score
1Neoplasm of the adrenal cortex (HP:0100641)4.58211032
2Hepatoblastoma (HP:0002884)3.88278456
3Amyotrophic lateral sclerosis (HP:0007354)3.85979156
4Diastasis recti (HP:0001540)3.56079450
5Abnormality of the labia minora (HP:0012880)3.46819482
6Neoplasm of the adrenal gland (HP:0100631)3.44696275
7Bile duct proliferation (HP:0001408)3.37129703
8Abnormal biliary tract physiology (HP:0012439)3.37129703
9Intestinal atresia (HP:0011100)3.31325466
10Agnosia (HP:0010524)3.20457456
11Chronic hepatic failure (HP:0100626)3.12591723
12Metaphyseal dysplasia (HP:0100255)3.11972216
13Ependymoma (HP:0002888)3.08433772
14Medulloblastoma (HP:0002885)2.97142329
15Molar tooth sign on MRI (HP:0002419)2.93416467
16Abnormality of midbrain morphology (HP:0002418)2.93416467
17Glioma (HP:0009733)2.91598620
18Atrophy/Degeneration involving motor neurons (HP:0007373)2.82653026
19True hermaphroditism (HP:0010459)2.82521378
20Pancreatic fibrosis (HP:0100732)2.79927181
21Abnormality of lateral ventricle (HP:0030047)2.76476707
22Hyperventilation (HP:0002883)2.76156372
23Abnormality of the astrocytes (HP:0100707)2.75464981
24Astrocytoma (HP:0009592)2.75464981
25Pancreatic cysts (HP:0001737)2.70549481
26Nephroblastoma (Wilms tumor) (HP:0002667)2.67329016
27Absent rod-and cone-mediated responses on ERG (HP:0007688)2.61671206
28Meckel diverticulum (HP:0002245)2.61053106
29Rhabdomyosarcoma (HP:0002859)2.56406876
30Abnormality of the ileum (HP:0001549)2.55867003
31Aplasia/Hypoplasia of the uvula (HP:0010293)2.54641283
32Growth hormone deficiency (HP:0000824)2.53973491
33Embryonal renal neoplasm (HP:0011794)2.50965165
34Adrenal hypoplasia (HP:0000835)2.42770238
35Abnormality of chromosome stability (HP:0003220)2.40414089
36Mesangial abnormality (HP:0001966)2.34719064
37Hyperglycinemia (HP:0002154)2.32374462
38Chromosomal breakage induced by crosslinking agents (HP:0003221)2.30938294
39Sloping forehead (HP:0000340)2.28337509
40Cerebellar dysplasia (HP:0007033)2.27653864
41Colon cancer (HP:0003003)2.27557153
42Small intestinal stenosis (HP:0012848)2.27286822
43Duodenal stenosis (HP:0100867)2.27286822
44Nephronophthisis (HP:0000090)2.27198300
45Abnormality of the lower motor neuron (HP:0002366)2.27176666
46Clumsiness (HP:0002312)2.25155052
47Aplasia/Hypoplasia of the tongue (HP:0010295)2.22101787
48Abnormality of the duodenum (HP:0002246)2.21933706
49Facial hemangioma (HP:0000329)2.19530308
50Dandy-Walker malformation (HP:0001305)2.19296879
51Thyroiditis (HP:0100646)2.16003354
52Sclerocornea (HP:0000647)2.12916879
53Abnormality of the preputium (HP:0100587)2.12031270
54Medial flaring of the eyebrow (HP:0010747)2.11706700
55Postaxial foot polydactyly (HP:0001830)2.09800014
56Severe combined immunodeficiency (HP:0004430)2.09522866
57Chromsome breakage (HP:0040012)2.06854567
58Acute encephalopathy (HP:0006846)2.06829528
59Oligodactyly (hands) (HP:0001180)2.03976705
60Anencephaly (HP:0002323)2.03832504
61Hyperglycinuria (HP:0003108)2.03599609
62Decreased central vision (HP:0007663)2.02620846
63Volvulus (HP:0002580)2.02453108
64Combined immunodeficiency (HP:0005387)1.99978580
65Preaxial hand polydactyly (HP:0001177)1.98412444
66Abnormal lung lobation (HP:0002101)1.98025956
67Abnormality of the carotid arteries (HP:0005344)1.94865207
68Stomach cancer (HP:0012126)1.94548050
69Oligodactyly (HP:0012165)1.93824441
70Tubulointerstitial nephritis (HP:0001970)1.92720448
71Absent speech (HP:0001344)1.90438622
72Embryonal neoplasm (HP:0002898)1.86790302
73Patellar aplasia (HP:0006443)1.82722052
743-Methylglutaconic aciduria (HP:0003535)1.81569866
75Neoplasm of striated muscle (HP:0009728)1.81369066
76Impulsivity (HP:0100710)1.81242237
77Drooling (HP:0002307)1.80845931
78Tented upper lip vermilion (HP:0010804)1.79978603
79Broad-based gait (HP:0002136)1.78671540
80Abnormality of the parathyroid morphology (HP:0011766)1.77886724
81Acute necrotizing encephalopathy (HP:0006965)1.76611643
82Constricted visual fields (HP:0001133)1.75241408
83Degeneration of the lateral corticospinal tracts (HP:0002314)1.74325098
84Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.74325098
85Hypoplasia of the pons (HP:0012110)1.73953134
86Occipital encephalocele (HP:0002085)1.73851952
87Cystic liver disease (HP:0006706)1.73645240
88Abnormality of the corticospinal tract (HP:0002492)1.71972660
89Neoplasm of the liver (HP:0002896)1.71885156
90Abnormality of serine family amino acid metabolism (HP:0010894)1.71657020
91Abnormality of glycine metabolism (HP:0010895)1.71657020
92Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.71431951
93Abnormality of alanine metabolism (HP:0010916)1.71431951
94Hyperalaninemia (HP:0003348)1.71431951
95Optic nerve coloboma (HP:0000588)1.71033129
96Abnormality of the renal medulla (HP:0100957)1.70903555
97Gastrointestinal atresia (HP:0002589)1.70294364
98Neoplasm of the oral cavity (HP:0100649)1.69362162
99Abolished electroretinogram (ERG) (HP:0000550)1.68958871
100Increased corneal curvature (HP:0100692)1.67109906

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK3.93748430
2PLK43.68146822
3BMPR1B3.11369914
4STK163.08713228
5BUB12.65730022
6NUAK12.61047280
7MAP3K42.50053269
8SRPK12.48530032
9ACVR1B2.40688759
10NTRK32.28591347
11WNK32.10863364
12TTK2.09621420
13FRK2.05494972
14CDC72.02477149
15PRKD32.02099197
16PLK31.90758566
17MAPK131.89034510
18BCR1.83554537
19MST41.81697452
20ERBB31.76649340
21MAP4K21.76424629
22WEE11.74645822
23TNIK1.69293628
24PINK11.66743906
25TRIM281.61127876
26BCKDK1.59641126
27MAP2K71.58337446
28VRK11.54005153
29PLK11.52968068
30PBK1.47144222
31MARK11.45970773
32NEK11.39606565
33MKNK11.35112925
34MKNK21.35063854
35EIF2AK11.34947272
36DYRK31.25006506
37VRK21.22813527
38MINK11.14937825
39BRSK21.14294886
40CSNK1G11.12962523
41KSR11.10532368
42CSNK1G31.07429901
43CSNK1A1L1.07375804
44PLK21.02256352
45CSNK1G21.01852211
46CHEK20.95893915
47SIK30.94326267
48EIF2AK30.93791695
49INSRR0.93502946
50CCNB10.89441034
51DYRK20.86597764
52ATR0.85596919
53PRKCE0.81126194
54MAP3K20.80666219
55AURKB0.77891938
56ADRBK20.75021417
57PAK30.74980561
58RAF10.71715242
59NTRK20.68593171
60ATM0.67349009
61RPS6KA40.64510818
62NEK20.60702840
63STK390.59997358
64PRKCG0.56163444
65CHEK10.54553474
66CASK0.51679973
67PRKCH0.51416842
68EIF2AK20.50193221
69MAPKAPK50.50187922
70YES10.49943117
71PNCK0.47463924
72TGFBR10.47165873
73MARK30.45291201
74CSNK1D0.44430755
75LIMK10.44317653
76ERBB40.42558169
77MAP3K140.42003272
78MAP2K10.41890826
79MAP3K60.41727386
80CDK90.41717517
81NME10.40532165
82GRK10.40144832
83IRAK20.39776445
84DYRK1A0.39061024
85MELK0.38335609
86PRKDC0.37324485
87ERBB20.35935869
88CDK180.35934077
89BRD40.34342077
90CDK10.32275090
91MUSK0.30288045
92CAMK2A0.29309301
93PRKD20.28983540
94BRSK10.27170424
95DMPK0.26773342
96CDK150.26630257
97SGK20.26330679
98STK30.25675527
99PRKCQ0.25281305
100CDK80.25174130

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.87006281
2Mismatch repair_Homo sapiens_hsa034303.84755049
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.57241245
4Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.34766335
5Fanconi anemia pathway_Homo sapiens_hsa034603.34686679
6Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.89000959
7Non-homologous end-joining_Homo sapiens_hsa034502.75257201
8Proteasome_Homo sapiens_hsa030502.38643117
9DNA replication_Homo sapiens_hsa030302.30638682
10Base excision repair_Homo sapiens_hsa034102.07248735
11Propanoate metabolism_Homo sapiens_hsa006402.02930256
12p53 signaling pathway_Homo sapiens_hsa041152.01041224
13Homologous recombination_Homo sapiens_hsa034401.98249129
14Steroid biosynthesis_Homo sapiens_hsa001001.97875483
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.96905264
16Basal transcription factors_Homo sapiens_hsa030221.96722446
17Cell cycle_Homo sapiens_hsa041101.95091574
18Parkinsons disease_Homo sapiens_hsa050121.81175103
19Nucleotide excision repair_Homo sapiens_hsa034201.74041667
20Butanoate metabolism_Homo sapiens_hsa006501.73689450
21Oxidative phosphorylation_Homo sapiens_hsa001901.70973500
22Spliceosome_Homo sapiens_hsa030401.67017468
23RNA polymerase_Homo sapiens_hsa030201.64493295
24Phototransduction_Homo sapiens_hsa047441.60477084
252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.56447586
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.51887801
27RNA degradation_Homo sapiens_hsa030181.40843072
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.39322693
29Huntingtons disease_Homo sapiens_hsa050161.32071380
30RNA transport_Homo sapiens_hsa030131.26271342
31Peroxisome_Homo sapiens_hsa041461.25071085
32Fatty acid elongation_Homo sapiens_hsa000621.23022497
33Regulation of autophagy_Homo sapiens_hsa041401.22501931
34Oocyte meiosis_Homo sapiens_hsa041141.19393010
35Selenocompound metabolism_Homo sapiens_hsa004501.17602562
36Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.15188669
37Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.14508789
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.14277282
39Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.01998222
40Pyrimidine metabolism_Homo sapiens_hsa002401.00759711
41Nicotine addiction_Homo sapiens_hsa050331.00678693
42Sulfur relay system_Homo sapiens_hsa041220.99889456
43Alzheimers disease_Homo sapiens_hsa050100.97257492
44Pyruvate metabolism_Homo sapiens_hsa006200.95743501
45Fatty acid metabolism_Homo sapiens_hsa012120.95547131
46Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.86947733
47Basal cell carcinoma_Homo sapiens_hsa052170.85891971
48Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.83654022
49Folate biosynthesis_Homo sapiens_hsa007900.80493702
50Tryptophan metabolism_Homo sapiens_hsa003800.80168056
51Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.78064881
52Purine metabolism_Homo sapiens_hsa002300.77554439
53Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.75325203
54Fatty acid degradation_Homo sapiens_hsa000710.71906886
55One carbon pool by folate_Homo sapiens_hsa006700.71028672
56alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.68239713
57Olfactory transduction_Homo sapiens_hsa047400.67935667
58Serotonergic synapse_Homo sapiens_hsa047260.65978437
59Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.64763663
60mRNA surveillance pathway_Homo sapiens_hsa030150.64609344
61Linoleic acid metabolism_Homo sapiens_hsa005910.62923456
62Colorectal cancer_Homo sapiens_hsa052100.61722089
63Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.60002292
64Ether lipid metabolism_Homo sapiens_hsa005650.57961663
65Wnt signaling pathway_Homo sapiens_hsa043100.57832912
66Thyroid cancer_Homo sapiens_hsa052160.57349579
67Nitrogen metabolism_Homo sapiens_hsa009100.56536387
68Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.52780403
69Long-term depression_Homo sapiens_hsa047300.51316222
70Hedgehog signaling pathway_Homo sapiens_hsa043400.49271807
71Cocaine addiction_Homo sapiens_hsa050300.48144373
72Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.47757621
73Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.47690895
74Metabolic pathways_Homo sapiens_hsa011000.46490698
75SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45861261
76GABAergic synapse_Homo sapiens_hsa047270.43221399
77Prostate cancer_Homo sapiens_hsa052150.41572654
78Dopaminergic synapse_Homo sapiens_hsa047280.38867299
79Retinol metabolism_Homo sapiens_hsa008300.36742091
80Glutamatergic synapse_Homo sapiens_hsa047240.35182303
81Fatty acid biosynthesis_Homo sapiens_hsa000610.34876194
82Fat digestion and absorption_Homo sapiens_hsa049750.33589988
83Steroid hormone biosynthesis_Homo sapiens_hsa001400.31929315
84Melanogenesis_Homo sapiens_hsa049160.31509096
85Axon guidance_Homo sapiens_hsa043600.30066435
86Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.29532163
87NOD-like receptor signaling pathway_Homo sapiens_hsa046210.28509234
88Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.28446953
89Cardiac muscle contraction_Homo sapiens_hsa042600.28196482
90TGF-beta signaling pathway_Homo sapiens_hsa043500.27634186
91Pentose and glucuronate interconversions_Homo sapiens_hsa000400.27292331
92Circadian entrainment_Homo sapiens_hsa047130.26627268
93Taste transduction_Homo sapiens_hsa047420.26424828
94Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.25832274
95Lysine degradation_Homo sapiens_hsa003100.24820305
96Glutathione metabolism_Homo sapiens_hsa004800.24441521
97Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.24266695
98Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.21156404
99Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.20843953
100Morphine addiction_Homo sapiens_hsa050320.20692525

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