VN1R84P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA synthesis involved in DNA repair (GO:0000731)7.55036964
2replication fork processing (GO:0031297)6.65222922
3regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)5.61775048
4positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)5.61775048
5regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)5.03075682
6positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO5.03075682
7positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)4.95909467
8protein-chromophore linkage (GO:0018298)4.84787481
9positive regulation of mRNA catabolic process (GO:0061014)4.75380116
10negative regulation of phosphoprotein phosphatase activity (GO:0032515)4.71284245
11proline transport (GO:0015824)4.70003717
12cellular ketone body metabolic process (GO:0046950)4.68543704
13auditory receptor cell differentiation (GO:0042491)4.66738743
14water-soluble vitamin biosynthetic process (GO:0042364)4.55776161
15pyrimidine dimer repair (GO:0006290)4.52261300
16prostate gland growth (GO:0060736)4.45839964
17regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)4.45703478
18maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)4.26943925
19RNA destabilization (GO:0050779)4.14181507
20mitochondrial RNA metabolic process (GO:0000959)4.13955332
21ketone body metabolic process (GO:1902224)4.11774864
22serine family amino acid catabolic process (GO:0009071)4.01587962
23single strand break repair (GO:0000012)3.99962195
24response to UV-C (GO:0010225)3.98123872
25positive regulation of histone H3-K4 methylation (GO:0051571)3.90381780
26regulation of mRNA catabolic process (GO:0061013)3.90006143
27cell wall macromolecule catabolic process (GO:0016998)3.77852817
28regulation of alkaline phosphatase activity (GO:0010692)3.74752814
29spinal cord motor neuron differentiation (GO:0021522)3.69991894
30glycerophospholipid catabolic process (GO:0046475)3.66706918
31centriole replication (GO:0007099)3.65162670
32positive regulation of mRNA 3-end processing (GO:0031442)3.60369405
33negative regulation of keratinocyte proliferation (GO:0010839)3.57156042
34intra-S DNA damage checkpoint (GO:0031573)3.50865228
35alanine transport (GO:0032328)3.44111470
36regulation of histone H3-K4 methylation (GO:0051569)3.43670908
37retinal rod cell development (GO:0046548)3.42734660
38hair cell differentiation (GO:0035315)3.41785155
39negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.33522021
40positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.31660420
41regulation of cardioblast proliferation (GO:0003264)3.31603203
42regulation of secondary heart field cardioblast proliferation (GO:0003266)3.31603203
43regulation of memory T cell differentiation (GO:0043380)3.28757404
44fatty acid transmembrane transport (GO:1902001)3.27517391
45DNA strand renaturation (GO:0000733)3.26946006
46snRNA transcription (GO:0009301)3.25107121
47positive regulation of mRNA processing (GO:0050685)3.22821693
48mismatch repair (GO:0006298)3.21407684
49double-strand break repair via homologous recombination (GO:0000724)3.18937323
50positive regulation of mRNA metabolic process (GO:1903313)3.09740518
51cell wall macromolecule metabolic process (GO:0044036)3.08177735
52recombinational repair (GO:0000725)3.07990750
53carnitine shuttle (GO:0006853)3.06426316
54DNA-dependent DNA replication (GO:0006261)3.05990819
55ether lipid metabolic process (GO:0046485)3.04935881
56regulation of mRNA 3-end processing (GO:0031440)3.01852392
57carnitine transport (GO:0015879)3.00049576
58amino-acid betaine transport (GO:0015838)3.00049576
59regulation of keratinocyte proliferation (GO:0010837)2.98972308
60protein K6-linked ubiquitination (GO:0085020)2.93991351
61resolution of meiotic recombination intermediates (GO:0000712)2.93066069
62mast cell activation involved in immune response (GO:0002279)2.91059360
63mast cell degranulation (GO:0043303)2.91059360
64purine nucleobase biosynthetic process (GO:0009113)2.89928706
65L-fucose catabolic process (GO:0042355)2.89487890
66fucose catabolic process (GO:0019317)2.89487890
67L-fucose metabolic process (GO:0042354)2.89487890
68keratinocyte development (GO:0003334)2.87329402
69carnitine transmembrane transport (GO:1902603)2.86196222
70heparin biosynthetic process (GO:0030210)2.85798969
71heparin metabolic process (GO:0030202)2.85798969
72regulation of Golgi to plasma membrane protein transport (GO:0042996)2.85173705
73mannosylation (GO:0097502)2.84391728
74rRNA methylation (GO:0031167)2.83285859
75tetrahydrofolate metabolic process (GO:0046653)2.81659436
76negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.80351558
77negative regulation of execution phase of apoptosis (GO:1900118)2.74161320
78regulation of glucocorticoid secretion (GO:2000849)2.73241136
79viral mRNA export from host cell nucleus (GO:0046784)2.72060901
80regulation of translational elongation (GO:0006448)2.69132589
81Golgi to endosome transport (GO:0006895)2.68523009
82sensory perception of smell (GO:0007608)2.67455505
83coronary vasculature morphogenesis (GO:0060977)2.66324203
84glycerol ether metabolic process (GO:0006662)2.63198382
85platelet dense granule organization (GO:0060155)2.61944702
86inositol phosphate catabolic process (GO:0071545)2.61213135
87positive regulation of histone methylation (GO:0031062)2.61078814
88microtubule anchoring (GO:0034453)2.60885994
89forebrain morphogenesis (GO:0048853)2.58621906
90cilium or flagellum-dependent cell motility (GO:0001539)2.58153479
91reciprocal meiotic recombination (GO:0007131)2.57923791
92reciprocal DNA recombination (GO:0035825)2.57923791
93negative regulation of circadian rhythm (GO:0042754)2.56888713
94retinal cone cell development (GO:0046549)2.56398483
95methionine biosynthetic process (GO:0009086)2.55612148
96rRNA modification (GO:0000154)2.55303472
97DNA topological change (GO:0006265)2.54261965
98inner ear receptor cell development (GO:0060119)2.53302782
99glycoprotein catabolic process (GO:0006516)2.52589133
100detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)2.52136773

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse4.56025480
2SALL1_21062744_ChIP-ChIP_HESCs_Human3.75984642
3GATA1_22025678_ChIP-Seq_K562_Human3.47232785
4E2F7_22180533_ChIP-Seq_HELA_Human3.19469247
5IGF1R_20145208_ChIP-Seq_DFB_Human3.17704410
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.07282485
7MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.02418371
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.64425853
9VDR_22108803_ChIP-Seq_LS180_Human2.59358916
10ZNF274_21170338_ChIP-Seq_K562_Hela2.46887415
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.40597090
12CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.22581621
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.09777283
14FUS_26573619_Chip-Seq_HEK293_Human2.07624361
15HTT_18923047_ChIP-ChIP_STHdh_Human2.02609104
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.99311515
17EGR1_19374776_ChIP-ChIP_THP-1_Human1.97771625
18ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.94793169
19FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.79471261
20HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.73360215
21ER_23166858_ChIP-Seq_MCF-7_Human1.67475692
22SRF_21415370_ChIP-Seq_HL-1_Mouse1.66150026
23AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.65316069
24SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.64457511
25RBPJ_22232070_ChIP-Seq_NCS_Mouse1.59350722
26GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.57520074
27STAT3_23295773_ChIP-Seq_U87_Human1.56730124
28EWS_26573619_Chip-Seq_HEK293_Human1.56466495
29CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.54309282
30FLI1_27457419_Chip-Seq_LIVER_Mouse1.53207864
31DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.49333412
32TP53_22573176_ChIP-Seq_HFKS_Human1.48624765
33UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.42559468
34CBP_20019798_ChIP-Seq_JUKART_Human1.42336946
35IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.42336946
36IRF8_21731497_ChIP-ChIP_J774_Mouse1.41830587
37KLF5_20875108_ChIP-Seq_MESCs_Mouse1.41407360
38ELK1_19687146_ChIP-ChIP_HELA_Human1.40471453
39E2F4_17652178_ChIP-ChIP_JURKAT_Human1.40231461
40VDR_23849224_ChIP-Seq_CD4+_Human1.36956074
41ETV1_20927104_ChIP-Seq_GIST48_Human1.36633480
42CTBP1_25329375_ChIP-Seq_LNCAP_Human1.35931551
43BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.31499182
44TCF4_23295773_ChIP-Seq_U87_Human1.30268404
45PIAS1_25552417_ChIP-Seq_VCAP_Human1.30210182
46GABP_17652178_ChIP-ChIP_JURKAT_Human1.28046128
47KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.27826188
48ELF1_17652178_ChIP-ChIP_JURKAT_Human1.26272131
49P300_19829295_ChIP-Seq_ESCs_Human1.25490799
50CDX2_22108803_ChIP-Seq_LS180_Human1.24986876
51GBX2_23144817_ChIP-Seq_PC3_Human1.23343244
52NOTCH1_21737748_ChIP-Seq_TLL_Human1.22490574
53CRX_20693478_ChIP-Seq_RETINA_Mouse1.22432320
54SUZ12_27294783_Chip-Seq_NPCs_Mouse1.21633262
55PHF8_20622853_ChIP-Seq_HELA_Human1.21527253
56CTBP2_25329375_ChIP-Seq_LNCAP_Human1.21425389
57PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.21012523
58EGR1_23403033_ChIP-Seq_LIVER_Mouse1.20329846
59SMAD4_21799915_ChIP-Seq_A2780_Human1.19395781
60RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.18643874
61NR3C1_21868756_ChIP-Seq_MCF10A_Human1.15881941
62WT1_19549856_ChIP-ChIP_CCG9911_Human1.15786593
63CBX2_22325352_ChIP-Seq_293T-Rex_Human1.14668197
64RBPJ_21746931_ChIP-Seq_IB4_Human1.13155308
65RUNX2_22187159_ChIP-Seq_PCA_Human1.12950613
66FLI1_21867929_ChIP-Seq_TH2_Mouse1.10902747
67FOXA1_21572438_ChIP-Seq_LNCaP_Human1.10827215
68KDM5A_27292631_Chip-Seq_BREAST_Human1.10511824
69CREB1_15753290_ChIP-ChIP_HEK293T_Human1.10202203
70EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.09896010
71E2F1_18555785_Chip-Seq_ESCs_Mouse1.07759688
72PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07407070
73TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.06910311
74YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.06823535
75MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.06550512
76FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.05721261
77TCF4_22108803_ChIP-Seq_LS180_Human1.05617165
78GATA3_21878914_ChIP-Seq_MCF-7_Human1.05427006
79AR_25329375_ChIP-Seq_VCAP_Human1.05178061
80STAT3_18555785_Chip-Seq_ESCs_Mouse1.05048649
81TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04966774
82EZH2_27294783_Chip-Seq_NPCs_Mouse1.04356735
83CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.03229590
84NFYA_21822215_ChIP-Seq_K562_Human1.02796021
85P53_22387025_ChIP-Seq_ESCs_Mouse1.02706002
86VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.02466829
87PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.99407565
88SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.99400454
89MYC_18940864_ChIP-ChIP_HL60_Human0.98695733
90NANOG_19829295_ChIP-Seq_ESCs_Human0.97869581
91SOX2_19829295_ChIP-Seq_ESCs_Human0.97869581
92NANOG_18555785_Chip-Seq_ESCs_Mouse0.97727618
93OCT4_18555785_Chip-Seq_ESCs_Mouse0.97424296
94SUZ12_18555785_Chip-Seq_ESCs_Mouse0.96575710
95OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96575420
96NFYB_21822215_ChIP-Seq_K562_Human0.96479506
97ZNF263_19887448_ChIP-Seq_K562_Human0.95418068
98NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.95386249
99PADI4_21655091_ChIP-ChIP_MCF-7_Human0.94985508
100CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.94242230

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis4.74202097
2MP0003195_calcinosis4.44838658
3MP0000569_abnormal_digit_pigmentation4.34900987
4MP0010234_abnormal_vibrissa_follicle3.88995988
5MP0008057_abnormal_DNA_replication3.46559505
6MP0002638_abnormal_pupillary_reflex3.03065463
7MP0008995_early_reproductive_senescence2.62734053
8MP0002102_abnormal_ear_morphology2.61885029
9MP0009780_abnormal_chondrocyte_physiolo2.60543210
10MP0003787_abnormal_imprinting2.55845886
11MP0005365_abnormal_bile_salt2.42358098
12MP0003172_abnormal_lysosome_physiology2.40764854
13MP0002163_abnormal_gland_morphology2.32377446
14MP0004264_abnormal_extraembryonic_tissu2.32364836
15MP0002254_reproductive_system_inflammat2.24690918
16MP0001986_abnormal_taste_sensitivity2.19002345
17MP0008877_abnormal_DNA_methylation2.14147979
18MP0002234_abnormal_pharynx_morphology2.08966371
19MP0008775_abnormal_heart_ventricle2.07011358
20MP0010678_abnormal_skin_adnexa2.01460549
21MP0001293_anophthalmia1.77113982
22MP0004019_abnormal_vitamin_homeostasis1.66924318
23MP0001984_abnormal_olfaction1.63713528
24MP0003123_paternal_imprinting1.60660744
25MP0005174_abnormal_tail_pigmentation1.58920760
26MP0000647_abnormal_sebaceous_gland1.54887969
27MP0001502_abnormal_circadian_rhythm1.53418719
28MP0003186_abnormal_redox_activity1.50248311
29MP0002132_abnormal_respiratory_system1.47109167
30MP0003718_maternal_effect1.46972069
31MP0003943_abnormal_hepatobiliary_system1.46048167
32MP0005551_abnormal_eye_electrophysiolog1.42228597
33MP0000383_abnormal_hair_follicle1.39547132
34MP0004147_increased_porphyrin_level1.32721356
35MP0001661_extended_life_span1.31012387
36MP0005266_abnormal_metabolism1.30187167
37MP0010329_abnormal_lipoprotein_level1.28914786
38MP0000631_abnormal_neuroendocrine_gland1.28577749
39MP0005379_endocrine/exocrine_gland_phen1.26261593
40MP0003567_abnormal_fetal_cardiomyocyte1.25656014
41MP0003283_abnormal_digestive_organ1.24372825
42MP0009840_abnormal_foam_cell1.24308745
43MP0000015_abnormal_ear_pigmentation1.23583639
44MP0005410_abnormal_fertilization1.20687110
45MP0003121_genomic_imprinting1.20244893
46MP0003786_premature_aging1.18902403
47MP0008058_abnormal_DNA_repair1.18242973
48MP0010094_abnormal_chromosome_stability1.17628511
49MP0003868_abnormal_feces_composition1.16283716
50MP0004215_abnormal_myocardial_fiber1.15816492
51MP0001968_abnormal_touch/_nociception1.14917737
52MP0001545_abnormal_hematopoietic_system1.07135530
53MP0005397_hematopoietic_system_phenotyp1.07135530
54MP0005645_abnormal_hypothalamus_physiol1.06058121
55MP0005647_abnormal_sex_gland1.05690782
56MP0001324_abnormal_eye_pigmentation1.04360681
57MP0002876_abnormal_thyroid_physiology1.01518046
58MP0005220_abnormal_exocrine_pancreas1.01427416
59MP0000516_abnormal_urinary_system1.00677682
60MP0005367_renal/urinary_system_phenotyp1.00677682
61MP0009278_abnormal_bone_marrow1.00639481
62MP0001666_abnormal_nutrient_absorption0.96504315
63MP0002751_abnormal_autonomic_nervous0.93356774
64MP0003806_abnormal_nucleotide_metabolis0.92403642
65MP0006035_abnormal_mitochondrial_morpho0.90417420
66MP0005332_abnormal_amino_acid0.87197288
67MP0005389_reproductive_system_phenotype0.84319500
68MP0006036_abnormal_mitochondrial_physio0.83063737
69MP0001881_abnormal_mammary_gland0.83023144
70MP0005058_abnormal_lysosome_morphology0.82770496
71MP0006072_abnormal_retinal_apoptosis0.82637193
72MP0002928_abnormal_bile_duct0.81744296
73MP0004085_abnormal_heartbeat0.81687467
74MP0000377_abnormal_hair_follicle0.79665535
75MP0005253_abnormal_eye_physiology0.78698657
76MP0001929_abnormal_gametogenesis0.78145785
77MP0001697_abnormal_embryo_size0.77165708
78MP0000427_abnormal_hair_cycle0.76831250
79MP0003698_abnormal_male_reproductive0.76356251
80MP0005376_homeostasis/metabolism_phenot0.71647918
81MP0002938_white_spotting0.70678861
82MP0003890_abnormal_embryonic-extraembry0.67656804
83MP0002095_abnormal_skin_pigmentation0.67618762
84MP0001756_abnormal_urination0.67499799
85MP0003119_abnormal_digestive_system0.67150849
86MP0002089_abnormal_postnatal_growth/wei0.65809235
87MP0002088_abnormal_embryonic_growth/wei0.65060408
88MP0001944_abnormal_pancreas_morphology0.64801011
89MP0003984_embryonic_growth_retardation0.64725391
90MP0001486_abnormal_startle_reflex0.64358627
91MP0000538_abnormal_urinary_bladder0.63569289
92MP0001119_abnormal_female_reproductive0.61854046
93MP0001853_heart_inflammation0.61496442
94MP0002160_abnormal_reproductive_system0.60926003
95MP0002210_abnormal_sex_determination0.60522224
96MP0003137_abnormal_impulse_conducting0.60455952
97MP0003936_abnormal_reproductive_system0.59354715
98MP0008875_abnormal_xenobiotic_pharmacok0.58340495
99MP0002295_abnormal_pulmonary_circulatio0.57765169
100MP0009046_muscle_twitch0.57719110

Predicted human phenotypes

RankGene SetZ-score
1Fair hair (HP:0002286)3.84923466
2Pili torti (HP:0003777)3.72521428
3Constricted visual fields (HP:0001133)3.70080448
4Secondary amenorrhea (HP:0000869)3.56754894
5Cutaneous melanoma (HP:0012056)3.52185731
6Chromsome breakage (HP:0040012)3.50506389
7Chromosomal breakage induced by crosslinking agents (HP:0003221)3.42586325
8Decreased electroretinogram (ERG) amplitude (HP:0000654)3.33438434
9Attenuation of retinal blood vessels (HP:0007843)3.10743466
10Impulsivity (HP:0100710)3.09585309
11Neoplasm of the oral cavity (HP:0100649)3.09577464
12Generalized hypopigmentation of hair (HP:0011358)2.98182873
13Abnormal hair whorl (HP:0010721)2.93253851
14Volvulus (HP:0002580)2.89634515
15Hypothermia (HP:0002045)2.88640002
16Exotropia (HP:0000577)2.76793132
17Progressive macrocephaly (HP:0004481)2.75812635
18Neoplasm of the small intestine (HP:0100833)2.73749871
19White forelock (HP:0002211)2.69825050
20Abnormality of DNA repair (HP:0003254)2.67404866
21Pancreatic fibrosis (HP:0100732)2.66906227
22Absent speech (HP:0001344)2.66570096
23Severe visual impairment (HP:0001141)2.65134085
24Neonatal hypoglycemia (HP:0001998)2.64092650
25Patchy hypopigmentation of hair (HP:0011365)2.63597557
26Abnormality of serum amino acid levels (HP:0003112)2.60495098
27Hamartoma of the eye (HP:0010568)2.59713255
28Increased corneal curvature (HP:0100692)2.59712313
29Keratoconus (HP:0000563)2.59712313
30Papillary thyroid carcinoma (HP:0002895)2.59648570
31Abnormal hair laboratory examination (HP:0003328)2.56655796
32Abnormality of alanine metabolism (HP:0010916)2.55617282
33Hyperalaninemia (HP:0003348)2.55617282
34Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.55617282
35Adenoma sebaceum (HP:0009720)2.55551601
36Angiofibromas (HP:0010615)2.55551601
37Tented upper lip vermilion (HP:0010804)2.53745619
38Intrahepatic cholestasis (HP:0001406)2.52859318
39Intestinal atresia (HP:0011100)2.51413874
40True hermaphroditism (HP:0010459)2.49296783
41Nephronophthisis (HP:0000090)2.47713023
42Meningioma (HP:0002858)2.46575476
43Pancreatic cysts (HP:0001737)2.39709763
44Conjunctival hamartoma (HP:0100780)2.38958823
45Acute necrotizing encephalopathy (HP:0006965)2.37630134
46Dialeptic seizures (HP:0011146)2.35084155
47Thyroid carcinoma (HP:0002890)2.30731422
48Birth length less than 3rd percentile (HP:0003561)2.29296882
49Protruding tongue (HP:0010808)2.26549454
50Severe muscular hypotonia (HP:0006829)2.25472625
51Aplasia/Hypoplasia of the earlobes (HP:0009906)2.23504361
52Neoplasm of the adrenal cortex (HP:0100641)2.21077684
53Furrowed tongue (HP:0000221)2.20440343
54Long clavicles (HP:0000890)2.18057708
55Steatorrhea (HP:0002570)2.13971466
56Abnormality of mucopolysaccharide metabolism (HP:0011020)2.13598309
57Abnormality of polysaccharide metabolism (HP:0011012)2.13598309
58Abnormality of glycosaminoglycan metabolism (HP:0004371)2.13598309
59Mucopolysacchariduria (HP:0008155)2.12803419
60Urinary glycosaminoglycan excretion (HP:0003541)2.12803419
61Flat occiput (HP:0005469)2.07316678
62Limb hypertonia (HP:0002509)2.05235338
63Albinism (HP:0001022)2.05108789
64Abnormality of aspartate family amino acid metabolism (HP:0010899)2.01758233
65Hyperglycinemia (HP:0002154)2.01033641
66Amblyopia (HP:0000646)2.00397372
67Clumsiness (HP:0002312)1.99646061
68Optic disc pallor (HP:0000543)1.99255786
69Abnormality of the renal medulla (HP:0100957)1.99099275
70Hemiparesis (HP:0001269)1.97386003
71Aplasia/Hypoplasia of the tibia (HP:0005772)1.94451499
72Aqueductal stenosis (HP:0002410)1.93054741
73Cupped ear (HP:0000378)1.92521106
74Acute encephalopathy (HP:0006846)1.92251674
75Abnormality of the labia minora (HP:0012880)1.92210412
76Increased CSF lactate (HP:0002490)1.91849161
77Ovarian neoplasm (HP:0100615)1.91467200
78Atonic seizures (HP:0010819)1.89034862
79Abnormal mitochondria in muscle tissue (HP:0008316)1.88338506
80Increased serum lactate (HP:0002151)1.87530678
81Hematochezia (HP:0002573)1.84917262
82Ependymoma (HP:0002888)1.82693088
83Glycosuria (HP:0003076)1.82250161
84Abnormality of urine glucose concentration (HP:0011016)1.82250161
85Decreased activity of mitochondrial respiratory chain (HP:0008972)1.81440857
86Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.81440857
87Neoplasm of the thyroid gland (HP:0100031)1.81119762
88Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.79885413
89Abnormal protein N-linked glycosylation (HP:0012347)1.79885413
90Abnormal protein glycosylation (HP:0012346)1.79885413
91Abnormal glycosylation (HP:0012345)1.79885413
92Gastrointestinal atresia (HP:0002589)1.79069591
93Decreased central vision (HP:0007663)1.77352403
94Lethargy (HP:0001254)1.75977968
95Fat malabsorption (HP:0002630)1.75706797
96Disproportionate short-trunk short stature (HP:0003521)1.74377944
97Abnormality of vitamin B metabolism (HP:0004340)1.73923341
98Lymphangioma (HP:0100764)1.72337588
99Asplenia (HP:0001746)1.72330246
100Neoplasm of the adrenal gland (HP:0100631)1.71812188

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.28045885
2PDK24.67150161
3TAOK33.99492251
4WNK33.31990802
5MAP3K132.76485329
6FGFR22.74085546
7CASK2.69886621
8MAP3K42.68204253
9TRIM282.60684359
10PAK32.41890775
11PRKD32.41541634
12ERBB32.22600379
13NUAK11.84020825
14MAP3K141.60586148
15EIF2AK11.58166367
16BMPR21.53594784
17MAP2K71.52008166
18KSR21.45981869
19STK241.40855939
20ADRBK21.38179060
21MARK11.38037916
22INSRR1.31123734
23DAPK21.29640863
24NTRK31.28229069
25KSR11.24607999
26CAMK1D1.23493635
27FGFR31.20513225
28MAP4K21.18051561
29TEC1.16516277
30MAPK131.15165184
31CDK31.14510880
32RAF11.08799772
33BMPR1B1.06532621
34MKNK11.01943169
35PINK11.01691037
36CHEK20.96266060
37MAP2K10.95064894
38PRKAA20.92392362
39IRAK10.91380994
40PDK10.81848144
41DYRK1A0.80148695
42GRK10.79360965
43MAP3K20.78049548
44PLK30.77030233
45TSSK60.76622596
46ATM0.76074202
47PHKG20.74072473
48PHKG10.74072473
49NME10.73885760
50PDPK10.69542081
51FER0.67673986
52MAP3K70.67573117
53SRPK10.66410884
54PRKAA10.65812840
55PTK2B0.65142107
56MKNK20.65098449
57IKBKB0.61400457
58STK30.60069721
59CAMK1G0.58817517
60AKT30.57361007
61STK160.54916074
62TRPM70.52324737
63TLK10.51513145
64STK390.50233661
65CHUK0.49884246
66TNK20.49640876
67TAF10.49404002
68BTK0.48763443
69ACVR1B0.47157145
70MAP3K60.46998975
71TAOK10.46405869
72ITK0.45136900
73EPHA30.44406423
74PRKDC0.44180009
75ILK0.44138288
76LATS10.40670520
77ATR0.40086522
78MAPKAPK50.39678289
79EPHB10.39045580
80PRKCE0.38019490
81EIF2AK20.35288777
82DYRK30.34168921
83TNIK0.31668121
84PKN20.31202349
85NLK0.31019485
86PRKCH0.30736862
87TBK10.28984990
88OBSCN0.28851075
89PRKACA0.28607842
90IRAK40.28496810
91PRKCQ0.27219500
92HCK0.26713671
93MATK0.26672538
94PLK20.26627584
95PLK10.26560271
96FGR0.26357205
97CSNK1E0.26318371
98PRKCB0.25726759
99IKBKE0.25346253
100PRKG10.25346246

Predicted pathways (KEGG)

RankGene SetZ-score
1Homologous recombination_Homo sapiens_hsa034404.57574623
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.10527484
3One carbon pool by folate_Homo sapiens_hsa006703.87560044
4Selenocompound metabolism_Homo sapiens_hsa004503.52952832
5Cyanoamino acid metabolism_Homo sapiens_hsa004602.89724353
6Phototransduction_Homo sapiens_hsa047442.86671492
7Maturity onset diabetes of the young_Homo sapiens_hsa049502.46721122
8Basal transcription factors_Homo sapiens_hsa030222.38456986
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.36853789
10Butanoate metabolism_Homo sapiens_hsa006502.20815867
11Protein export_Homo sapiens_hsa030602.11855023
12Primary bile acid biosynthesis_Homo sapiens_hsa001202.09598055
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.06604388
14Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.05733877
15Fanconi anemia pathway_Homo sapiens_hsa034602.05317248
16Nucleotide excision repair_Homo sapiens_hsa034201.77511190
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.72477282
18Collecting duct acid secretion_Homo sapiens_hsa049661.68917777
19Caffeine metabolism_Homo sapiens_hsa002321.67354015
20Steroid biosynthesis_Homo sapiens_hsa001001.66461303
21Dorso-ventral axis formation_Homo sapiens_hsa043201.54018904
22Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.49231272
23Mismatch repair_Homo sapiens_hsa034301.42873367
24Ether lipid metabolism_Homo sapiens_hsa005651.41579651
25Vitamin B6 metabolism_Homo sapiens_hsa007501.38375763
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.34101912
27Olfactory transduction_Homo sapiens_hsa047401.33443895
28Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.30820973
29Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.29640841
30Non-homologous end-joining_Homo sapiens_hsa034501.27442552
31SNARE interactions in vesicular transport_Homo sapiens_hsa041301.24516616
32Base excision repair_Homo sapiens_hsa034101.20671823
33Propanoate metabolism_Homo sapiens_hsa006401.18730942
34Tryptophan metabolism_Homo sapiens_hsa003801.09674587
35Lysine degradation_Homo sapiens_hsa003101.09225492
36Fatty acid metabolism_Homo sapiens_hsa012121.08191110
37Vitamin digestion and absorption_Homo sapiens_hsa049771.07145341
38Pyruvate metabolism_Homo sapiens_hsa006201.02028154
39Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.98624240
40Taste transduction_Homo sapiens_hsa047420.94709653
41Fatty acid degradation_Homo sapiens_hsa000710.93957189
42DNA replication_Homo sapiens_hsa030300.93306572
43Nitrogen metabolism_Homo sapiens_hsa009100.88707106
44Glycosaminoglycan degradation_Homo sapiens_hsa005310.87521325
45Purine metabolism_Homo sapiens_hsa002300.85969496
46RNA degradation_Homo sapiens_hsa030180.85053377
47Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.84469465
48Nicotine addiction_Homo sapiens_hsa050330.83409950
49Oxidative phosphorylation_Homo sapiens_hsa001900.78323003
50Fat digestion and absorption_Homo sapiens_hsa049750.78313776
51Retinol metabolism_Homo sapiens_hsa008300.75627501
52N-Glycan biosynthesis_Homo sapiens_hsa005100.73383036
53Insulin secretion_Homo sapiens_hsa049110.69500309
54Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.66474033
55Glycerolipid metabolism_Homo sapiens_hsa005610.62305133
56Glycerophospholipid metabolism_Homo sapiens_hsa005640.61280302
57Synaptic vesicle cycle_Homo sapiens_hsa047210.61169686
58Rheumatoid arthritis_Homo sapiens_hsa053230.60844836
59Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.60377185
60Steroid hormone biosynthesis_Homo sapiens_hsa001400.58283023
61Linoleic acid metabolism_Homo sapiens_hsa005910.57475789
62RNA transport_Homo sapiens_hsa030130.56870486
63Spliceosome_Homo sapiens_hsa030400.55955784
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55901487
65Type I diabetes mellitus_Homo sapiens_hsa049400.55046413
66Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.55043996
67Peroxisome_Homo sapiens_hsa041460.54869659
68Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.53677525
69Metabolic pathways_Homo sapiens_hsa011000.50658718
70Fatty acid biosynthesis_Homo sapiens_hsa000610.49998668
71Type II diabetes mellitus_Homo sapiens_hsa049300.49931403
72Inositol phosphate metabolism_Homo sapiens_hsa005620.49362338
73Circadian rhythm_Homo sapiens_hsa047100.47215395
74p53 signaling pathway_Homo sapiens_hsa041150.46608879
75Sulfur metabolism_Homo sapiens_hsa009200.45772909
76Insulin resistance_Homo sapiens_hsa049310.44977715
77Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.42570626
78Pentose and glucuronate interconversions_Homo sapiens_hsa000400.41520848
79GABAergic synapse_Homo sapiens_hsa047270.36410493
80Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.35757195
81RNA polymerase_Homo sapiens_hsa030200.35434705
82Sphingolipid metabolism_Homo sapiens_hsa006000.34812782
83Chemical carcinogenesis_Homo sapiens_hsa052040.33027584
84mTOR signaling pathway_Homo sapiens_hsa041500.32992269
85Pyrimidine metabolism_Homo sapiens_hsa002400.32870286
86Thyroid hormone synthesis_Homo sapiens_hsa049180.31902255
87Tight junction_Homo sapiens_hsa045300.30882116
88Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.30604541
89Vascular smooth muscle contraction_Homo sapiens_hsa042700.27281025
90Jak-STAT signaling pathway_Homo sapiens_hsa046300.26872198
91RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.25173999
92alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.24699032
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.24591262
94Proteasome_Homo sapiens_hsa030500.24548707
95Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.24411517
96Glutathione metabolism_Homo sapiens_hsa004800.22822555
97Ovarian steroidogenesis_Homo sapiens_hsa049130.22362971
98Fructose and mannose metabolism_Homo sapiens_hsa000510.21939147
99Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.21110447
100Complement and coagulation cascades_Homo sapiens_hsa046100.20312992

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