ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	gonadal mesoderm development (GO:0007506)	8.44624704
2	negative regulation of meiosis (GO:0045835)	8.34282875
3	chromosome organization involved in meiosis (GO:0070192)	8.08133600
4	male meiosis I (GO:0007141)	8.05456251
5	positive regulation of meiosis (GO:0045836)	7.22187714
6	male meiosis (GO:0007140)	7.04717721
7	synaptonemal complex assembly (GO:0007130)	7.04185351
8	mitotic sister chromatid cohesion (GO:0007064)	6.85017691
9	sister chromatid cohesion (GO:0007062)	6.80071880
10	positive regulation of meiotic cell cycle (GO:0051446)	6.76345910
11	meiotic nuclear division (GO:0007126)	6.70803698
12	meiosis I (GO:0007127)	6.55598196
13	DNA synthesis involved in DNA repair (GO:0000731)	6.50896718
14	synaptonemal complex organization (GO:0070193)	6.45110677
15	DNA methylation involved in gamete generation (GO:0043046)	6.06814406
16	mitotic chromosome condensation (GO:0007076)	5.88286551
17	oogenesis (GO:0048477)	5.80934773
18	negative regulation of meiotic cell cycle (GO:0051447)	5.49848932
19	somatic hypermutation of immunoglobulin genes (GO:0016446)	5.49040194
20	somatic diversification of immune receptors via somatic mutation (GO:0002566)	5.49040194
21	meiotic cell cycle process (GO:1903046)	5.43497643
22	resolution of meiotic recombination intermediates (GO:0000712)	5.24590742
23	regulation of meiosis (GO:0040020)	5.20633788
24	regulation of meiotic cell cycle (GO:0051445)	4.95160300
25	female gamete generation (GO:0007292)	4.81883389
26	gene silencing by RNA (GO:0031047)	4.66044830
27	meiotic chromosome segregation (GO:0045132)	4.64089528
28	regulation of DNA endoreduplication (GO:0032875)	4.56778621
29	germ cell migration (GO:0008354)	4.55021182
30	chromatin remodeling at centromere (GO:0031055)	4.44895828
31	CENP-A containing nucleosome assembly (GO:0034080)	4.34441117
32	folic acid transport (GO:0015884)	4.18487769
33	histone exchange (GO:0043486)	4.12180897
34	telomere maintenance via semi-conservative replication (GO:0032201)	4.09738954
35	reciprocal meiotic recombination (GO:0007131)	3.92589024
36	reciprocal DNA recombination (GO:0035825)	3.92589024
37	DNA replication checkpoint (GO:0000076)	3.90869656
38	ncRNA 3-end processing (GO:0043628)	3.87817453
39	negative regulation of gene silencing (GO:0060969)	3.77648380
40	meiotic cell cycle (GO:0051321)	3.70083650
41	ribosomal small subunit assembly (GO:0000028)	3.68344615
42	DNA catabolic process, exonucleolytic (GO:0000738)	3.67612113
43	lymphangiogenesis (GO:0001946)	3.61758967
44	mitotic metaphase plate congression (GO:0007080)	3.53791086
45	regulation of Wnt signaling pathway involved in heart development (GO:0003307)	3.50829799
46	blastocyst development (GO:0001824)	3.49282473
47	telomere maintenance via recombination (GO:0000722)	3.47513834
48	oocyte maturation (GO:0001556)	3.41943392
49	germ cell development (GO:0007281)	3.37810878
50	mitotic recombination (GO:0006312)	3.37378974
51	DNA strand elongation involved in DNA replication (GO:0006271)	3.37345535
52	DNA replication initiation (GO:0006270)	3.33263706
53	DNA replication-independent nucleosome organization (GO:0034724)	3.32751245
54	DNA replication-independent nucleosome assembly (GO:0006336)	3.32751245
55	sex differentiation (GO:0007548)	3.27437458
56	formation of translation preinitiation complex (GO:0001731)	3.26570257
57	DNA strand elongation (GO:0022616)	3.26430044
58	spindle assembly involved in mitosis (GO:0090307)	3.23592653
59	negative regulation of nuclear division (GO:0051784)	3.23577157
60	nucleotide transmembrane transport (GO:1901679)	3.18745747
61	metaphase plate congression (GO:0051310)	3.15698059
62	chromosome organization (GO:0051276)	3.15312792
63	positive regulation of translational initiation (GO:0045948)	3.11870235
64	regulation of chromosome segregation (GO:0051983)	3.07259777
65	protein localization to chromosome, centromeric region (GO:0071459)	3.07173943
66	regulation of double-strand break repair via homologous recombination (GO:0010569)	3.02896858
67	regulation of centriole replication (GO:0046599)	3.01638482
68	protein localization to chromosome (GO:0034502)	2.96929617
69	protein K6-linked ubiquitination (GO:0085020)	2.94714819
70	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.94334750
71	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.94334750
72	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	2.93595574
73	spermatid development (GO:0007286)	2.92317638
74	DNA biosynthetic process (GO:0071897)	2.89357517
75	DNA double-strand break processing (GO:0000729)	2.89181369
76	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.87544083
77	regulation of helicase activity (GO:0051095)	2.87134362
78	DNA alkylation (GO:0006305)	2.86784577
79	DNA methylation (GO:0006306)	2.86784577
80	histone H2A acetylation (GO:0043968)	2.86482278
81	embryonic foregut morphogenesis (GO:0048617)	2.85712503
82	determination of adult lifespan (GO:0008340)	2.83536772
83	nuclear division (GO:0000280)	2.82128202
84	positive regulation of male gonad development (GO:2000020)	2.80317008
85	positive regulation of catenin import into nucleus (GO:0035413)	2.79741773
86	regulation of sister chromatid cohesion (GO:0007063)	2.78193876
87	mismatch repair (GO:0006298)	2.77483268
88	gene silencing (GO:0016458)	2.77460405
89	nucleotide-excision repair, DNA gap filling (GO:0006297)	2.76808821
90	N-terminal protein amino acid acetylation (GO:0006474)	2.76067441
91	attachment of spindle microtubules to kinetochore (GO:0008608)	2.76037185
92	negative regulation of cell division (GO:0051782)	2.73578206
93	kinetochore organization (GO:0051383)	2.68629057
94	positive regulation of chromosome segregation (GO:0051984)	2.68539106
95	establishment of integrated proviral latency (GO:0075713)	2.68287475
96	proteasome assembly (GO:0043248)	2.67890750
97	somatic recombination of immunoglobulin gene segments (GO:0016447)	2.67635816
98	regulation of meiosis I (GO:0060631)	13.6601523
99	piRNA metabolic process (GO:0034587)	11.3312106
100	synapsis (GO:0007129)	11.0126703

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	6.69262529
2	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	4.86431619
3	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	4.31615682
4	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	4.31615682
5	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	4.31615682
6	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.31801108
7	E2F4_17652178_ChIP-ChIP_JURKAT_Human	3.30602859
8	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.24040041
9	IGF1R_20145208_ChIP-Seq_DFB_Human	3.19694717
10	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.88056698
11	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.86911211
12	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.82996099
13	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.66651943
14	VDR_22108803_ChIP-Seq_LS180_Human	2.56392233
15	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.47999179
16	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.47977513
17	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.44375165
18	ZNF274_21170338_ChIP-Seq_K562_Hela	2.44147119
19	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.20584578
20	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.16339868
21	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	2.15172246
22	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	2.10666804
23	MYCN_18555785_ChIP-Seq_MESCs_Mouse	2.05010328
24	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.01600094
25	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	2.01355995
26	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.00064586
27	AR_21909140_ChIP-Seq_LNCAP_Human	1.95038192
28	DCP1A_22483619_ChIP-Seq_HELA_Human	1.94108125
29	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.91140286
30	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.89176575
31	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.87609260
32	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.78736949
33	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.75405727
34	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.71729285
35	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.66138349
36	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.65779779
37	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.63156754
38	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.62121112
39	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.60136198
40	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.58978138
41	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.55680802
42	VDR_23849224_ChIP-Seq_CD4+_Human	1.55454788
43	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.55120450
44	TTF2_22483619_ChIP-Seq_HELA_Human	1.54432654
45	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.53152558
46	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.50097650
47	FOXP3_21729870_ChIP-Seq_TREG_Human	1.49735884
48	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.48505814
49	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.46920472
50	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.46071577
51	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.44309189
52	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.38613117
53	EGR1_19374776_ChIP-ChIP_THP-1_Human	1.38522234
54	ZNF263_19887448_ChIP-Seq_K562_Human	1.33033135
55	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.32772225
56	GABP_19822575_ChIP-Seq_HepG2_Human	1.32560858
57	ELK1_19687146_ChIP-ChIP_HELA_Human	1.32265136
58	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.31322174
59	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.23229292
60	IRF1_19129219_ChIP-ChIP_H3396_Human	1.19664859
61	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.07806469
62	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.03860394
63	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.03305183
64	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.99983093
65	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	0.99181650
66	HTT_18923047_ChIP-ChIP_STHdh_Human	0.97937916
67	TCF3_18692474_ChIP-Seq_MESCs_Mouse	0.96781860
68	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.96141882
69	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.95797866
70	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.95621799
71	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.95285647
72	GATA3_20176728_ChIP-ChIP_TSCs_Mouse	0.95091989
73	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.95047517
74	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.94029472
75	TCF3_18467660_ChIP-ChIP_MESCs_Mouse	0.91605712
76	SALL4_18804426_ChIP-ChIP_MESCs_Mouse	0.90953621
77	TRIM28_19339689_ChIP-ChIP_MESCs_Mouse	0.88609026
78	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	0.88573610
79	NANOG_16518401_ChIP-PET_MESCs_Mouse	0.88049812
80	ZIC3_20872845_ChIP-ChIP_MESCs_Mouse	0.87403294
81	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.86231539
82	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.86215331
83	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.85661332
84	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.85307461
85	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	0.82882878
86	TCF3_18692474_ChIP-Seq_MEFs_Mouse	0.80358100
87	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	0.80334328
88	HOXB7_26014856_ChIP-Seq_BT474_Human	0.79995705
89	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.79735533
90	NACC1_18358816_ChIP-ChIP_MESCs_Mouse	0.79732832
91	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	0.79684689
92	SOX17_20123909_ChIP-Seq_XEN_Mouse	0.78975909
93	TP53_22573176_ChIP-Seq_HFKS_Human	0.78447143
94	ERG_20887958_ChIP-Seq_HPC-7_Mouse	0.77350083
95	BCAT_22108803_ChIP-Seq_LS180_Human	0.77331475
96	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.76434804
97	NANOG_18358816_ChIP-ChIP_MESCs_Mouse	0.75527757
98	TAF15_26573619_Chip-Seq_HEK293_Human	0.75429732
99	RNF2_27304074_Chip-Seq_NSC_Mouse	0.75173858
100	SETDB1_19884257_ChIP-Seq_MESCs_Mouse	0.74775176

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0010368_abnormal_lymphatic_system	6.00754279
2	MP0008877_abnormal_DNA_methylation	5.40697255
3	MP0003693_abnormal_embryo_hatching	4.48868324
4	MP0008058_abnormal_DNA_repair	4.43445626
5	MP0004957_abnormal_blastocyst_morpholog	3.64219338
6	MP0008260_abnormal_autophagy	3.56299859
7	MP0002210_abnormal_sex_determination	3.52444755
8	MP0001929_abnormal_gametogenesis	3.15181077
9	MP0010094_abnormal_chromosome_stability	3.08972299
10	MP0005174_abnormal_tail_pigmentation	2.98084906
11	MP0004147_increased_porphyrin_level	2.92305190
12	MP0001145_abnormal_male_reproductive	2.78688410
13	MP0000653_abnormal_sex_gland	2.56116834
14	MP0003646_muscle_fatigue	2.41358237
15	MP0008057_abnormal_DNA_replication	2.39150541
16	MP0003698_abnormal_male_reproductive	2.39001790
17	MP0003077_abnormal_cell_cycle	2.38575824
18	MP0003111_abnormal_nucleus_morphology	2.30824284
19	MP0002160_abnormal_reproductive_system	2.22597310
20	MP0008932_abnormal_embryonic_tissue	2.00647265
21	MP0001879_abnormal_lymphatic_vessel	1.92949225
22	MP0001188_hyperpigmentation	1.91208499
23	MP0003183_abnormal_peptide_metabolism	1.87090880
24	MP0003890_abnormal_embryonic-extraembry	1.84293020
25	MP0001730_embryonic_growth_arrest	1.76360809
26	MP0003806_abnormal_nucleotide_metabolis	1.76121378
27	MP0002796_impaired_skin_barrier	1.73337491
28	MP0000015_abnormal_ear_pigmentation	1.58149393
29	MP0003123_paternal_imprinting	1.54493250
30	MP0003718_maternal_effect	1.54464515
31	MP0010307_abnormal_tumor_latency	1.52538110
32	MP0001177_atelectasis	1.51872676
33	MP0005409_darkened_coat_color	1.48631187
34	MP0001119_abnormal_female_reproductive	1.46487730
35	MP0006035_abnormal_mitochondrial_morpho	1.43047156
36	MP0010352_gastrointestinal_tract_polyps	1.38410004
37	MP0002163_abnormal_gland_morphology	1.38240471
38	MP0002161_abnormal_fertility/fecundity	1.36946131
39	MP0000490_abnormal_crypts_of	1.34640171
40	MP0008007_abnormal_cellular_replicative	1.34077164
41	MP0005670_abnormal_white_adipose	1.32435827
42	MP0002084_abnormal_developmental_patter	1.28692129
43	MP0000462_abnormal_digestive_system	1.28549940
44	MP0000350_abnormal_cell_proliferation	1.24814693
45	MP0005389_reproductive_system_phenotype	1.22746257
46	MP0001661_extended_life_span	1.13739839
47	MP0003699_abnormal_female_reproductive	1.11794333
48	MP0002085_abnormal_embryonic_tissue	1.10947241
49	MP0005075_abnormal_melanosome_morpholog	1.08935378
50	MP0000358_abnormal_cell_content/	1.08377482
51	MP0003936_abnormal_reproductive_system	1.04844912
52	MP0003186_abnormal_redox_activity	1.04174049
53	MP0004197_abnormal_fetal_growth/weight/	1.02450632
54	MP0005379_endocrine/exocrine_gland_phen	1.00687922
55	MP0005501_abnormal_skin_physiology	1.00591661
56	MP0003937_abnormal_limbs/digits/tail_de	1.00173959
57	MP0002095_abnormal_skin_pigmentation	0.99831485
58	MP0005380_embryogenesis_phenotype	0.99161730
59	MP0001672_abnormal_embryogenesis/_devel	0.99161730
60	MP0004233_abnormal_muscle_weight	0.98908278
61	MP0003880_abnormal_central_pattern	0.98853294
62	MP0002080_prenatal_lethality	0.98803263
63	MP0001697_abnormal_embryo_size	0.98716583
64	MP0004215_abnormal_myocardial_fiber	0.96228115
65	MP0004885_abnormal_endolymph	0.89686597
66	MP0003567_abnormal_fetal_cardiomyocyte	0.89463010
67	MP0003959_abnormal_lean_body	0.87039519
68	MP0000383_abnormal_hair_follicle	0.86921813
69	MP0000569_abnormal_digit_pigmentation	0.84176498
70	MP0003787_abnormal_imprinting	0.82422487
71	MP0003943_abnormal_hepatobiliary_system	0.82094596
72	MP0003119_abnormal_digestive_system	0.81954001
73	MP0010030_abnormal_orbit_morphology	0.80862638
74	MP0002086_abnormal_extraembryonic_tissu	0.78498153
75	MP0004782_abnormal_surfactant_physiolog	0.77479146
76	MP0000313_abnormal_cell_death	0.76644514
77	MP0003121_genomic_imprinting	0.68294520
78	MP0009379_abnormal_foot_pigmentation	0.66520668
79	MP0003786_premature_aging	0.65477256
80	MP0001764_abnormal_homeostasis	0.61201336
81	MP0000647_abnormal_sebaceous_gland	0.60663144
82	MP0009697_abnormal_copulation	0.60474329
83	MP0010678_abnormal_skin_adnexa	0.58550593
84	MP0006292_abnormal_olfactory_placode	0.57753426
85	MP0003861_abnormal_nervous_system	0.56952337
86	MP0005410_abnormal_fertilization	0.56826704
87	MP0003984_embryonic_growth_retardation	0.54998905
88	MP0002088_abnormal_embryonic_growth/wei	0.54723369
89	MP0009703_decreased_birth_body	0.54514195
90	MP0005647_abnormal_sex_gland	0.54285628
91	MP0008995_early_reproductive_senescence	0.53602960
92	MP0003448_altered_tumor_morphology	0.52177064
93	MP0002928_abnormal_bile_duct	0.50872315
94	MP0000467_abnormal_esophagus_morphology	0.49561603
95	MP0002735_abnormal_chemical_nociception	0.49252912
96	MP0000678_abnormal_parathyroid_gland	0.46927285
97	MP0005330_cardiomyopathy	0.46219387
98	MP0005058_abnormal_lysosome_morphology	0.45748012
99	MP0005384_cellular_phenotype	0.45235153
100	MP0003950_abnormal_plasma_membrane	0.44750347

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Osteomalacia (HP:0002749)	5.52727731
2	Volvulus (HP:0002580)	5.19428260
3	Degeneration of the lateral corticospinal tracts (HP:0002314)	4.92820863
4	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	4.92820863
5	Shoulder girdle muscle weakness (HP:0003547)	4.46861115
6	Abnormality of the corticospinal tract (HP:0002492)	4.44040517
7	Amyotrophic lateral sclerosis (HP:0007354)	4.40043849
8	Chromosomal breakage induced by crosslinking agents (HP:0003221)	4.06706582
9	Delayed epiphyseal ossification (HP:0002663)	4.03674026
10	Chromsome breakage (HP:0040012)	3.93535713
11	Abnormality of the lower motor neuron (HP:0002366)	3.92156388
12	Abnormality of the costochondral junction (HP:0000919)	3.80159457
13	Agnosia (HP:0010524)	3.71137245
14	Upper motor neuron abnormality (HP:0002127)	3.61339220
15	Ectopic kidney (HP:0000086)	3.60223876
16	Hyperglycinuria (HP:0003108)	3.53537299
17	Scotoma (HP:0000575)	3.49357758
18	Ependymoma (HP:0002888)	3.46961118
19	Carpal bone hypoplasia (HP:0001498)	3.40287611
20	Horizontal nystagmus (HP:0000666)	3.13759058
21	Gonadotropin excess (HP:0000837)	3.05805417
22	Retinal dysplasia (HP:0007973)	3.02432674
23	Abnormality of the labia minora (HP:0012880)	2.97182878
24	Rhabdomyosarcoma (HP:0002859)	2.86981392
25	Rimmed vacuoles (HP:0003805)	2.85870610
26	Abnormal lung lobation (HP:0002101)	2.80852530
27	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	2.80549428
28	Increased nuchal translucency (HP:0010880)	2.74053070
29	Abnormality of DNA repair (HP:0003254)	2.73104264
30	Basal cell carcinoma (HP:0002671)	2.70425819
31	Impaired vibration sensation in the lower limbs (HP:0002166)	2.68782417
32	Duodenal stenosis (HP:0100867)	2.68652966
33	Small intestinal stenosis (HP:0012848)	2.68652966
34	Septate vagina (HP:0001153)	2.66809135
35	Reticulocytopenia (HP:0001896)	2.62824647
36	Atrophy/Degeneration involving motor neurons (HP:0007373)	2.61313315
37	Abnormality of serine family amino acid metabolism (HP:0010894)	2.59105039
38	Abnormality of glycine metabolism (HP:0010895)	2.59105039
39	Hyperglycinemia (HP:0002154)	2.58711951
40	Abnormality of the renal collecting system (HP:0004742)	2.57912516
41	Rickets (HP:0002748)	2.52589414
42	Glioma (HP:0009733)	2.48659445
43	Azoospermia (HP:0000027)	2.44117616
44	Urinary urgency (HP:0000012)	2.33411423
45	Horseshoe kidney (HP:0000085)	2.33193806
46	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.31834111
47	Colon cancer (HP:0003003)	2.28825030
48	Biliary tract neoplasm (HP:0100574)	2.24431709
49	Neoplasm of the colon (HP:0100273)	2.23327968
50	Duplicated collecting system (HP:0000081)	2.22567768
51	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.21650595
52	Abnormal spermatogenesis (HP:0008669)	2.21094537
53	Small hand (HP:0200055)	2.19918956
54	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.18877041
55	Medulloblastoma (HP:0002885)	2.17990447
56	Microvesicular hepatic steatosis (HP:0001414)	2.17188455
57	Abnormality of the duodenum (HP:0002246)	2.17152170
58	Thin bony cortex (HP:0002753)	2.16670403
59	Birth length less than 3rd percentile (HP:0003561)	2.14972241
60	Widely patent fontanelles and sutures (HP:0004492)	2.14560056
61	Abnormality of the astrocytes (HP:0100707)	2.11527779
62	Astrocytoma (HP:0009592)	2.11527779
63	Enlarged epiphyses (HP:0010580)	2.11238642
64	Short tibia (HP:0005736)	2.11161069
65	Meckel diverticulum (HP:0002245)	2.09105834
66	Neoplasm of the oral cavity (HP:0100649)	2.08590496
67	Abnormality of chromosome stability (HP:0003220)	2.06606393
68	Microglossia (HP:0000171)	2.04440304
69	Type II lissencephaly (HP:0007260)	2.03085634
70	Metaphyseal cupping (HP:0003021)	2.01880204
71	Bilateral microphthalmos (HP:0007633)	2.01145814
72	Neoplasm of the rectum (HP:0100743)	2.00439190
73	Neoplasm of the small intestine (HP:0100833)	1.97034527
74	Gastrointestinal carcinoma (HP:0002672)	1.95342220
75	Malignant gastrointestinal tract tumors (HP:0006749)	1.95342220
76	Rectal fistula (HP:0100590)	1.92947317
77	Rectovaginal fistula (HP:0000143)	1.92947317
78	Metaphyseal irregularity (HP:0003025)	1.92544105
79	Abnormality of the vocal cords (HP:0008777)	1.92257614
80	Urinary bladder sphincter dysfunction (HP:0002839)	1.92029156
81	Abnormality of the ileum (HP:0001549)	1.91301103
82	Limb-girdle muscle weakness (HP:0003325)	1.88848384
83	Fused cervical vertebrae (HP:0002949)	1.88401529
84	Abnormality of the preputium (HP:0100587)	1.87373614
85	Tubulointerstitial nephritis (HP:0001970)	1.87183560
86	Supernumerary spleens (HP:0009799)	1.86924474
87	Absent radius (HP:0003974)	1.85684334
88	Oligodactyly (hands) (HP:0001180)	1.85475968
89	Neoplasm of striated muscle (HP:0009728)	1.84886712
90	Absent thumb (HP:0009777)	1.84386057
91	Abnormality of the fovea (HP:0000493)	1.79783108
92	Asplenia (HP:0001746)	1.79413692
93	Vertebral arch anomaly (HP:0008438)	1.79326285
94	Spontaneous abortion (HP:0005268)	1.78795102
95	Flat occiput (HP:0005469)	1.78257339
96	Aplasia/Hypoplasia of the nipples (HP:0006709)	1.77950956
97	Duplication of thumb phalanx (HP:0009942)	1.76590837
98	Cortical dysplasia (HP:0002539)	1.76583579
99	Short middle phalanx of the 5th finger (HP:0004220)	1.76343822
100	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.76214084

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ACVR1B	6.47475598
2	CDK19	5.22215849
3	PNCK	5.21585067
4	PBK	4.05702665
5	TTK	3.64454947
6	PLK4	3.16713909
7	ZAK	2.74905095
8	MAP3K2	2.21506186
9	WEE1	2.20856784
10	STK24	2.13284781
11	STK38L	2.09174559
12	KSR2	2.07814651
13	WNK4	1.72473629
14	BRSK1	1.66245065
15	CDC7	1.64074549
16	PLK1	1.61280208
17	MATK	1.49203369
18	STK39	1.48277690
19	BUB1	1.41945454
20	EPHA4	1.41572487
21	PASK	1.39915701
22	BRAF	1.39531846
23	TAF1	1.35387838
24	NTRK3	1.33082971
25	STK3	1.26506489
26	YES1	1.19591980
27	MET	1.17431455
28	EIF2AK3	1.16207350
29	CDK8	1.14780483
30	KSR1	1.14274771
31	RAF1	1.08744068
32	STK16	1.05047877
33	ATR	1.04918130
34	NEK9	1.03630160
35	WNK1	0.99351615
36	PHKG1	0.98749947
37	PHKG2	0.98749947
38	KIT	0.98029023
39	CHEK2	0.92947229
40	BMX	0.89250046
41	BRSK2	0.87222071
42	PDK2	0.80894875
43	ATM	0.80222759
44	CHEK1	0.77885896
45	DYRK3	0.77231948
46	TYRO3	0.75860841
47	AURKA	0.71969618
48	MAP3K8	0.71277432
49	PLK3	0.69742412
50	NEK6	0.69710534
51	CDK7	0.68820278
52	PDGFRB	0.67713588
53	CLK1	0.66748138
54	RPS6KB1	0.66678871
55	MELK	0.65937205
56	AURKB	0.65225292
57	LMTK2	0.63290764
58	CCNB1	0.62206267
59	BCKDK	0.57296301
60	ABL2	0.55831095
61	OXSR1	0.52996795
62	CDK4	0.52512014
63	CDK12	0.51636420
64	TSSK6	0.50768620
65	STK38	0.50283541
66	SRPK1	0.49351426
67	EGFR	0.46979581
68	PRKCI	0.43265124
69	CAMK1G	0.43144819
70	MAP3K7	0.42938645
71	ERBB4	0.42647766
72	PLK2	0.42278561
73	PIM1	0.40235619
74	SGK1	0.38625401
75	MAP3K4	0.38155673
76	PRKDC	0.37294910
77	MAP3K13	0.37063043
78	PTK2B	0.36970258
79	NEK1	0.36791583
80	MAP3K9	0.33045665
81	STK11	0.31662870
82	FGR	0.31488306
83	NEK2	0.30545428
84	CDK1	0.29988128
85	MAP3K1	0.28701525
86	RPS6KA1	0.28486624
87	STK4	0.28256668
88	BMPR1B	0.27807419
89	TIE1	0.27469617
90	CSNK2A2	0.27141287
91	GRK1	0.25593050
92	CSNK2A1	0.25508998
93	CSNK1G2	0.25185616
94	CDK2	0.24968685
95	VRK1	0.24351996
96	CDK11A	0.23929783
97	SCYL2	0.20357705
98	CSF1R	0.19086219
99	PRKCG	0.18592518
100	CDK3	0.17344180

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Mismatch repair_Homo sapiens_hsa03430	5.78922570
2	DNA replication_Homo sapiens_hsa03030	5.60488592
3	Base excision repair_Homo sapiens_hsa03410	3.90365954
4	Non-homologous end-joining_Homo sapiens_hsa03450	3.55274588
5	Fanconi anemia pathway_Homo sapiens_hsa03460	3.31426789
6	Cell cycle_Homo sapiens_hsa04110	3.21816027
7	Nucleotide excision repair_Homo sapiens_hsa03420	3.12881241
8	Homologous recombination_Homo sapiens_hsa03440	3.08708312
9	Regulation of autophagy_Homo sapiens_hsa04140	2.86030087
10	Basal transcription factors_Homo sapiens_hsa03022	2.76952125
11	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.54350523
12	RNA transport_Homo sapiens_hsa03013	2.52378544
13	Dorso-ventral axis formation_Homo sapiens_hsa04320	2.18879612
14	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.00828006
15	Folate biosynthesis_Homo sapiens_hsa00790	1.97235631
16	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.93761448
17	Oocyte meiosis_Homo sapiens_hsa04114	1.92934052
18	mRNA surveillance pathway_Homo sapiens_hsa03015	1.79843961
19	Ribosome_Homo sapiens_hsa03010	1.78221736
20	RNA degradation_Homo sapiens_hsa03018	1.65140905
21	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.64363800
22	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.48812289
23	p53 signaling pathway_Homo sapiens_hsa04115	1.39391708
24	Propanoate metabolism_Homo sapiens_hsa00640	1.39263890
25	Pyrimidine metabolism_Homo sapiens_hsa00240	1.37784574
26	One carbon pool by folate_Homo sapiens_hsa00670	1.27435367
27	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	1.07033256
28	RNA polymerase_Homo sapiens_hsa03020	1.06542391
29	Fatty acid elongation_Homo sapiens_hsa00062	1.02736484
30	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.02203268
31	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.00222712
32	Proteasome_Homo sapiens_hsa03050	0.89507677
33	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.87915622
34	Steroid biosynthesis_Homo sapiens_hsa00100	0.85560482
35	beta-Alanine metabolism_Homo sapiens_hsa00410	0.84225934
36	Spliceosome_Homo sapiens_hsa03040	0.79768398
37	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.79606391
38	Purine metabolism_Homo sapiens_hsa00230	0.79077817
39	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.73196275
40	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.70745466
41	Fatty acid degradation_Homo sapiens_hsa00071	0.69993212
42	Fatty acid metabolism_Homo sapiens_hsa01212	0.68056097
43	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.67247343
44	Sulfur relay system_Homo sapiens_hsa04122	0.63876294
45	mTOR signaling pathway_Homo sapiens_hsa04150	0.62845705
46	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.62807316
47	ABC transporters_Homo sapiens_hsa02010	0.61834555
48	Selenocompound metabolism_Homo sapiens_hsa00450	0.60958584
49	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.57285889
50	Melanoma_Homo sapiens_hsa05218	0.55065783
51	Circadian rhythm_Homo sapiens_hsa04710	0.48784980
52	Wnt signaling pathway_Homo sapiens_hsa04310	0.48435974
53	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.45607597
54	Phototransduction_Homo sapiens_hsa04744	0.45357717
55	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.44993593
56	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.44524768
57	ErbB signaling pathway_Homo sapiens_hsa04012	0.39434135
58	Shigellosis_Homo sapiens_hsa05131	0.39267827
59	HTLV-I infection_Homo sapiens_hsa05166	0.39107860
60	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.38385467
61	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.36847826
62	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.35834060
63	Pentose phosphate pathway_Homo sapiens_hsa00030	0.32783725
64	Huntingtons disease_Homo sapiens_hsa05016	0.31010675
65	Nicotine addiction_Homo sapiens_hsa05033	0.28912432
66	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.28790194
67	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.28504845
68	AMPK signaling pathway_Homo sapiens_hsa04152	0.28242228
69	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.26482127
70	Type II diabetes mellitus_Homo sapiens_hsa04930	0.25763882
71	Protein export_Homo sapiens_hsa03060	0.23733818
72	Metabolic pathways_Homo sapiens_hsa01100	0.23687551
73	Hippo signaling pathway_Homo sapiens_hsa04390	0.20456565
74	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.19141325
75	Endocytosis_Homo sapiens_hsa04144	0.18144488
76	Carbon metabolism_Homo sapiens_hsa01200	0.17563432
77	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.17305586
78	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.17075597
79	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.15777974
80	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.14032525
81	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.13578835
82	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.11327039
83	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.10642036
84	Primary immunodeficiency_Homo sapiens_hsa05340	0.10134053
85	Glutathione metabolism_Homo sapiens_hsa00480	0.10099884
86	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.09176968
87	Colorectal cancer_Homo sapiens_hsa05210	0.07551353
88	Peroxisome_Homo sapiens_hsa04146	0.06600621
89	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.05797615
90	Olfactory transduction_Homo sapiens_hsa04740	0.04884721
91	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.04544159
92	MAPK signaling pathway_Homo sapiens_hsa04010	0.04123461
93	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.03978576
94	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.03436504
95	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.02873977
96	Tyrosine metabolism_Homo sapiens_hsa00350	0.02746763
97	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.02108326
98	Rap1 signaling pathway_Homo sapiens_hsa04015	0.01804058
99	Caffeine metabolism_Homo sapiens_hsa00232	0.01478384
100	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.00804912

VN1R87P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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