ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	fusion of sperm to egg plasma membrane (GO:0007342)	8.41965921
2	acrosome reaction (GO:0007340)	8.01690353
3	regulation of female receptivity (GO:0045924)	7.84986100
4	sperm motility (GO:0030317)	7.75845649
5	regulation of phospholipase A2 activity (GO:0032429)	7.47586261
6	response to pheromone (GO:0019236)	6.93923740
7	rRNA methylation (GO:0031167)	6.83670767
8	female mating behavior (GO:0060180)	6.72223514
9	regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)	6.64064671
10	regulation of cholesterol esterification (GO:0010872)	6.51869579
11	plasma membrane fusion (GO:0045026)	6.38058421
12	rRNA modification (GO:0000154)	5.81939842
13	single strand break repair (GO:0000012)	5.78423563
14	sperm-egg recognition (GO:0035036)	5.72256586
15	low-density lipoprotein particle remodeling (GO:0034374)	5.67535183
16	multicellular organism reproduction (GO:0032504)	5.64558958
17	sperm capacitation (GO:0048240)	5.64061385
18	chromosome condensation (GO:0030261)	5.61423693
19	spermatid development (GO:0007286)	5.61114516
20	spermatid nucleus differentiation (GO:0007289)	5.53896152
21	negative regulation of Rho protein signal transduction (GO:0035024)	5.38926701
22	binding of sperm to zona pellucida (GO:0007339)	5.33422389
23	cellular ketone body metabolic process (GO:0046950)	5.28285336
24	DNA packaging (GO:0006323)	5.27009582
25	negative regulation of inclusion body assembly (GO:0090084)	5.22722084
26	reproduction (GO:0000003)	5.06535879
27	axonemal dynein complex assembly (GO:0070286)	4.89897036
28	calcium ion-dependent exocytosis (GO:0017156)	4.74918697
29	ketone body metabolic process (GO:1902224)	4.64554033
30	spermatogenesis (GO:0007283)	4.63369295
31	regulation of somitogenesis (GO:0014807)	4.63324326
32	regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)	4.63050624
33	endocrine process (GO:0050886)	4.63050624
34	regulation of systemic arterial blood pressure by hormone (GO:0001990)	4.63050624
35	male gamete generation (GO:0048232)	4.61284768
36	cell-cell recognition (GO:0009988)	4.58599922
37	protein-chromophore linkage (GO:0018298)	4.39646282
38	microtubule severing (GO:0051013)	4.32847176
39	microtubule depolymerization (GO:0007019)	4.31871406
40	regulation of microtubule-based movement (GO:0060632)	4.24754708
41	protein polyglutamylation (GO:0018095)	4.23433227
42	sexual reproduction (GO:0019953)	4.23345672
43	gamete generation (GO:0007276)	4.19675995
44	phosphatidylethanolamine biosynthetic process (GO:0006646)	4.13470512
45	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-	4.05266761
46	regulation of inclusion body assembly (GO:0090083)	4.04697984
47	positive regulation of macrophage derived foam cell differentiation (GO:0010744)	3.96559172
48	regulation of cilium movement (GO:0003352)	3.96176727
49	regulation of Rab GTPase activity (GO:0032313)	3.86154965
50	positive regulation of Rab GTPase activity (GO:0032851)	3.86154965
51	coenzyme catabolic process (GO:0009109)	3.83059010
52	negative regulation of T cell receptor signaling pathway (GO:0050860)	3.76071406
53	phosphatidylethanolamine metabolic process (GO:0046337)	3.74863163
54	single fertilization (GO:0007338)	3.74838594
55	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	3.63485338
56	cilium or flagellum-dependent cell motility (GO:0001539)	3.61145843
57	cilium movement (GO:0003341)	3.54417379
58	microtubule polymerization or depolymerization (GO:0031109)	3.54270491
59	regulation of Rac protein signal transduction (GO:0035020)	3.51838449
60	regulation of systemic arterial blood pressure (GO:0003073)	3.51239184
61	nephron epithelium morphogenesis (GO:0072088)	3.50192396
62	nephron tubule morphogenesis (GO:0072078)	3.50192396
63	regulation of excretion (GO:0044062)	3.48897037
64	motile cilium assembly (GO:0044458)	3.48156083
65	multicellular organismal reproductive process (GO:0048609)	3.45482154
66	negative regulation of mesenchymal cell apoptotic process (GO:2001054)	3.44476006
67	centriole replication (GO:0007099)	3.43167560
68	adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)	3.41491392
69	cell differentiation involved in metanephros development (GO:0072202)	3.40504607
70	regulation of lipoprotein metabolic process (GO:0050746)	3.34033953
71	regulation of histone H3-K27 methylation (GO:0061085)	3.31413307
72	epithelial cilium movement (GO:0003351)	3.30995924
73	receptor recycling (GO:0001881)	3.22760982
74	nephron tubule formation (GO:0072079)	3.21809053
75	primary amino compound metabolic process (GO:1901160)	3.21120612
76	glomerular epithelial cell development (GO:0072310)	3.16681972
77	regulation of renal sodium excretion (GO:0035813)	3.15659100
78	cellular biogenic amine biosynthetic process (GO:0042401)	3.13765144
79	regulation of cardioblast proliferation (GO:0003264)	3.11913346
80	regulation of secondary heart field cardioblast proliferation (GO:0003266)	3.11913346
81	cerebral cortex neuron differentiation (GO:0021895)	3.08975288
82	relaxation of smooth muscle (GO:0044557)	3.08864700
83	transmission of nerve impulse (GO:0019226)	3.07263905
84	response to acidic pH (GO:0010447)	3.06823379
85	negative regulation of myotube differentiation (GO:0010832)	3.05742122
86	amine biosynthetic process (GO:0009309)	3.05634688
87	cell wall macromolecule catabolic process (GO:0016998)	3.05612219
88	glomerular visceral epithelial cell development (GO:0072015)	3.05125653
89	renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)	3.03124897
90	organic cation transport (GO:0015695)	2.97215133
91	fertilization (GO:0009566)	2.94150643
92	regulation of autophagic vacuole assembly (GO:2000785)	2.94044110
93	germ cell development (GO:0007281)	2.86743210
94	positive regulation of catenin import into nucleus (GO:0035413)	2.84672079
95	multicellular organismal reproductive behavior (GO:0033057)	2.82253999
96	centriole assembly (GO:0098534)	2.80887102
97	auditory behavior (GO:0031223)	2.79461450
98	negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)	2.74126194
99	urinary tract smooth muscle contraction (GO:0014848)	2.72542582
100	protein targeting to Golgi (GO:0000042)	2.70504669

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.12818410
2	EZH2_22144423_ChIP-Seq_EOC_Human	2.63801891
3	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.63630581
4	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.50752733
5	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	2.50752733
6	TAF15_26573619_Chip-Seq_HEK293_Human	2.35509760
7	ER_23166858_ChIP-Seq_MCF-7_Human	2.12479779
8	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	2.07544704
9	FUS_26573619_Chip-Seq_HEK293_Human	2.02324865
10	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.91947718
11	ERA_21632823_ChIP-Seq_H3396_Human	1.91671420
12	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.83816823
13	P300_19829295_ChIP-Seq_ESCs_Human	1.79666680
14	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.79567613
15	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.79161048
16	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.76513192
17	CBP_20019798_ChIP-Seq_JUKART_Human	1.76513192
18	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.74967579
19	IGF1R_20145208_ChIP-Seq_DFB_Human	1.71605082
20	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.69055650
21	GBX2_23144817_ChIP-Seq_PC3_Human	1.66605439
22	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.62343365
23	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.61109410
24	TP53_18474530_ChIP-ChIP_U2OS_Human	1.60240278
25	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.59691242
26	DROSHA_22980978_ChIP-Seq_HELA_Human	1.56815000
27	AR_25329375_ChIP-Seq_VCAP_Human	1.55613228
28	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.54817894
29	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.52350689
30	VDR_22108803_ChIP-Seq_LS180_Human	1.51877526
31	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.51693978
32	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.51547515
33	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.49461686
34	RAC3_21632823_ChIP-Seq_H3396_Human	1.47380274
35	SMAD4_21799915_ChIP-Seq_A2780_Human	1.46021138
36	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.44591394
37	STAT3_23295773_ChIP-Seq_U87_Human	1.42389850
38	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.41430152
39	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.39164287
40	CTCF_27219007_Chip-Seq_Bcells_Human	1.38082237
41	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.35416997
42	E2F1_20622854_ChIP-Seq_HELA_Human	1.35303705
43	P53_21459846_ChIP-Seq_SAOS-2_Human	1.35049863
44	TAF2_19829295_ChIP-Seq_ESCs_Human	1.33824894
45	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.33039937
46	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.32883311
47	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.31907187
48	MYC_19829295_ChIP-Seq_ESCs_Human	1.31590113
49	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.29689647
50	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.28243435
51	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.26849939
52	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.24587427
53	PHF8_20622854_ChIP-Seq_HELA_Human	1.24545938
54	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.21174349
55	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.20412688
56	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.19053157
57	RUNX2_22187159_ChIP-Seq_PCA_Human	1.17289455
58	HOXB7_26014856_ChIP-Seq_BT474_Human	1.17013725
59	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.16242961
60	TCF4_23295773_ChIP-Seq_U87_Human	1.16146523
61	NANOG_20526341_ChIP-Seq_ESCs_Human	1.15936430
62	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.13982268
63	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.13776942
64	REST_21632747_ChIP-Seq_MESCs_Mouse	1.13613655
65	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.12410666
66	BCL6_27268052_Chip-Seq_Bcells_Human	1.11518524
67	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.11404188
68	SMRT_27268052_Chip-Seq_Bcells_Human	1.11400298
69	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.11222733
70	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.09327337
71	TP63_22573176_ChIP-Seq_HFKS_Human	1.08978344
72	OCT4_20526341_ChIP-Seq_ESCs_Human	1.08655417
73	TBL1_22424771_ChIP-Seq_293T_Human	1.08606655
74	BCOR_27268052_Chip-Seq_Bcells_Human	1.08543776
75	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.08389872
76	PHF8_20622853_ChIP-Seq_HELA_Human	1.07843573
77	NANOG_19829295_ChIP-Seq_ESCs_Human	1.07426514
78	SOX2_19829295_ChIP-Seq_ESCs_Human	1.07426514
79	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.06571056
80	RUNX1_26923725_Chip-Seq_HPCs_Mouse	1.06503796
81	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.06307117
82	CTCF_20526341_ChIP-Seq_ESCs_Human	1.05303820
83	NCOR_22424771_ChIP-Seq_293T_Human	1.04790295
84	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.04702622
85	SMC4_20622854_ChIP-Seq_HELA_Human	1.04068059
86	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.03659813
87	NFYB_21822215_ChIP-Seq_K562_Human	1.03626048
88	ETV1_20927104_ChIP-Seq_GIST48_Human	1.02031087
89	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.01881306
90	ZNF274_21170338_ChIP-Seq_K562_Hela	1.01104431
91	KDM2B_26808549_Chip-Seq_REH_Human	1.00750077
92	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.00191751
93	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.99859148
94	CBP_21632823_ChIP-Seq_H3396_Human	0.99599057
95	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.99558678
96	AHR_22903824_ChIP-Seq_MCF-7_Human	0.99417045
97	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.99271613
98	CEBPB_22108803_ChIP-Seq_LS180_Human	0.99188133
99	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	0.99100261
100	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.98693715

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005410_abnormal_fertilization	7.72233886
2	MP0003136_yellow_coat_color	4.95888542
3	MP0009780_abnormal_chondrocyte_physiolo	4.56030242
4	MP0005379_endocrine/exocrine_gland_phen	3.51785421
5	MP0002132_abnormal_respiratory_system	3.48642464
6	MP0005423_abnormal_somatic_nervous	3.18166632
7	MP0002653_abnormal_ependyma_morphology	2.84293217
8	MP0003698_abnormal_male_reproductive	2.70004242
9	MP0002163_abnormal_gland_morphology	2.47742697
10	MP0003879_abnormal_hair_cell	2.36500743
11	MP0005171_absent_coat_pigmentation	2.26691159
12	MP0000569_abnormal_digit_pigmentation	2.24484059
13	MP0001929_abnormal_gametogenesis	2.17468806
14	MP0001968_abnormal_touch/_nociception	2.11327757
15	MP0001348_abnormal_lacrimal_gland	2.02982388
16	MP0001529_abnormal_vocalization	1.97084958
17	MP0005187_abnormal_penis_morphology	1.93816270
18	MP0006276_abnormal_autonomic_nervous	1.90803557
19	MP0002138_abnormal_hepatobiliary_system	1.87936148
20	MP0005670_abnormal_white_adipose	1.80515810
21	MP0005377_hearing/vestibular/ear_phenot	1.77686919
22	MP0003878_abnormal_ear_physiology	1.77686919
23	MP0001984_abnormal_olfaction	1.76063649
24	MP0008775_abnormal_heart_ventricle	1.64795727
25	MP0004859_abnormal_synaptic_plasticity	1.50369475
26	MP0004270_analgesia	1.49672468
27	MP0002249_abnormal_larynx_morphology	1.48451820
28	MP0002909_abnormal_adrenal_gland	1.46311747
29	MP0000372_irregular_coat_pigmentation	1.46198513
30	MP0002282_abnormal_trachea_morphology	1.44409901
31	MP0001485_abnormal_pinna_reflex	1.43292139
32	MP0005365_abnormal_bile_salt	1.42632714
33	MP0000681_abnormal_thyroid_gland	1.42414523
34	MP0005248_abnormal_Harderian_gland	1.41542072
35	MP0002161_abnormal_fertility/fecundity	1.39391675
36	MP0004085_abnormal_heartbeat	1.21197264
37	MP0002734_abnormal_mechanical_nocicepti	1.17559447
38	MP0005595_abnormal_vascular_smooth	1.15759676
39	MP0001486_abnormal_startle_reflex	1.15578152
40	MP0002928_abnormal_bile_duct	1.15463801
41	MP0001502_abnormal_circadian_rhythm	1.14271501
42	MP0003137_abnormal_impulse_conducting	1.10787910
43	MP0002638_abnormal_pupillary_reflex	1.03781990
44	MP0005646_abnormal_pituitary_gland	1.03267751
45	MP0000026_abnormal_inner_ear	1.02921909
46	MP0002822_catalepsy	1.01457021
47	MP0000647_abnormal_sebaceous_gland	1.01136757
48	MP0002733_abnormal_thermal_nociception	0.99447755
49	MP0000230_abnormal_systemic_arterial	0.99330446
50	MP0000631_abnormal_neuroendocrine_gland	0.99041454
51	MP0005551_abnormal_eye_electrophysiolog	0.98556360
52	MP0004885_abnormal_endolymph	0.98454750
53	MP0001501_abnormal_sleep_pattern	0.97244526
54	MP0002735_abnormal_chemical_nociception	0.96594483
55	MP0002938_white_spotting	0.95176744
56	MP0000534_abnormal_ureter_morphology	0.93502612
57	MP0001970_abnormal_pain_threshold	0.93360116
58	MP0002693_abnormal_pancreas_physiology	0.91382927
59	MP0003718_maternal_effect	0.90775549
60	MP0002272_abnormal_nervous_system	0.90172375
61	MP0003011_delayed_dark_adaptation	0.89076307
62	MP0002210_abnormal_sex_determination	0.87851832
63	MP0001963_abnormal_hearing_physiology	0.87173114
64	MP0005647_abnormal_sex_gland	0.86902545
65	MP0002736_abnormal_nociception_after	0.86606927
66	MP0002572_abnormal_emotion/affect_behav	0.84398625
67	MP0002102_abnormal_ear_morphology	0.83646222
68	MP0003638_abnormal_response/metabolism_	0.83132186
69	MP0002229_neurodegeneration	0.82353914
70	MP0005535_abnormal_body_temperature	0.81257492
71	MP0000049_abnormal_middle_ear	0.80687722
72	MP0003119_abnormal_digestive_system	0.80640188
73	MP0005084_abnormal_gallbladder_morpholo	0.79166529
74	MP0006035_abnormal_mitochondrial_morpho	0.77383878
75	MP0005620_abnormal_muscle_contractility	0.77154273
76	MP0002557_abnormal_social/conspecific_i	0.74348464
77	MP0003122_maternal_imprinting	0.73569224
78	MP0003938_abnormal_ear_development	0.71772762
79	MP0004484_altered_response_of	0.71112268
80	MP0000383_abnormal_hair_follicle	0.68310484
81	MP0001851_eye_inflammation	0.68208461
82	MP0001765_abnormal_ion_homeostasis	0.68193575
83	MP0001905_abnormal_dopamine_level	0.68144816
84	MP0004381_abnormal_hair_follicle	0.66628140
85	MP0002234_abnormal_pharynx_morphology	0.66340800
86	MP0009046_muscle_twitch	0.66251674
87	MP0000653_abnormal_sex_gland	0.65447553
88	MP0003959_abnormal_lean_body	0.62738005
89	MP0003646_muscle_fatigue	0.62389960
90	MP0000613_abnormal_salivary_gland	0.61675194
91	MP0000678_abnormal_parathyroid_gland	0.61069955
92	MP0006072_abnormal_retinal_apoptosis	0.59756122
93	MP0002127_abnormal_cardiovascular_syste	0.59746688
94	MP0004924_abnormal_behavior	0.59036930
95	MP0005386_behavior/neurological_phenoty	0.59036930
96	MP0005645_abnormal_hypothalamus_physiol	0.58831942
97	MP0010329_abnormal_lipoprotein_level	0.58382280
98	MP0005253_abnormal_eye_physiology	0.58373559
99	MP0002095_abnormal_skin_pigmentation	0.58318754
100	MP0001145_abnormal_male_reproductive	0.57539068

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Potter facies (HP:0002009)	9.04099635
2	Facial shape deformation (HP:0011334)	9.04099635
3	Severe visual impairment (HP:0001141)	6.50416881
4	Widely patent fontanelles and sutures (HP:0004492)	6.10504781
5	Abnormal rod and cone electroretinograms (HP:0008323)	5.26486971
6	Type II lissencephaly (HP:0007260)	5.22582777
7	Cerebellar dysplasia (HP:0007033)	4.91083868
8	Bony spicule pigmentary retinopathy (HP:0007737)	4.53899828
9	Attenuation of retinal blood vessels (HP:0007843)	4.52346885
10	Abnormal urine output (HP:0012590)	4.40888010
11	Wide cranial sutures (HP:0010537)	4.33143339
12	Abnormality of renal excretion (HP:0011036)	4.20880897
13	Retinal dysplasia (HP:0007973)	3.89584868
14	Abnormal ciliary motility (HP:0012262)	3.62980098
15	Abnormal respiratory motile cilium physiology (HP:0012261)	3.34933320
16	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.33649446
17	Absent/shortened dynein arms (HP:0200106)	3.25763518
18	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.25763518
19	Abnormality of macular pigmentation (HP:0008002)	3.18775281
20	Concave nail (HP:0001598)	3.13505565
21	Abnormal respiratory motile cilium morphology (HP:0005938)	3.12385026
22	Abnormal respiratory epithelium morphology (HP:0012253)	3.12385026
23	Hyperkalemia (HP:0002153)	2.97860226
24	True hermaphroditism (HP:0010459)	2.92670647
25	Chronic bronchitis (HP:0004469)	2.85040897
26	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	2.74978654
27	Rhinitis (HP:0012384)	2.67482797
28	Congenital sensorineural hearing impairment (HP:0008527)	2.66466167
29	Short chin (HP:0000331)	2.60062665
30	Pancreatic cysts (HP:0001737)	2.58114424
31	Occipital encephalocele (HP:0002085)	2.57590045
32	Abnormality of urine glucose concentration (HP:0011016)	2.55920014
33	Glycosuria (HP:0003076)	2.55920014
34	Nasal polyposis (HP:0100582)	2.53177083
35	Absent eyebrow (HP:0002223)	2.45914191
36	Renal dysplasia (HP:0000110)	2.44364512
37	Optic nerve hypoplasia (HP:0000609)	2.41655230
38	Nephronophthisis (HP:0000090)	2.40873150
39	Tubular atrophy (HP:0000092)	2.38926655
40	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.32475813
41	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	2.26229159
42	Absent epiphyses (HP:0010577)	2.26229159
43	Hypotension (HP:0002615)	2.21502464
44	Chronic hepatic failure (HP:0100626)	2.20034694
45	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	2.18995412
46	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.12823210
47	Polydipsia (HP:0001959)	2.11069079
48	Abnormal drinking behavior (HP:0030082)	2.11069079
49	Epileptic encephalopathy (HP:0200134)	2.09963422
50	Abnormality of the renal medulla (HP:0100957)	2.09874244
51	Multifactorial inheritance (HP:0001426)	2.06428632
52	Decreased circulating renin level (HP:0003351)	2.06141327
53	Bile duct proliferation (HP:0001408)	2.06098651
54	Abnormal biliary tract physiology (HP:0012439)	2.06098651
55	Abnormality of the femoral head (HP:0003368)	2.05177321
56	Pancreatic fibrosis (HP:0100732)	2.05113850
57	Unilateral renal agenesis (HP:0000122)	2.04016927
58	Azoospermia (HP:0000027)	2.03258771
59	Double outlet right ventricle (HP:0001719)	2.02434201
60	Congenital malformation of the right heart (HP:0011723)	2.02434201
61	Prominent supraorbital ridges (HP:0000336)	2.02091017
62	Shoulder girdle muscle weakness (HP:0003547)	2.01268952
63	Enlarged epiphyses (HP:0010580)	2.00628972
64	Infertility (HP:0000789)	1.99498281
65	Tracheomalacia (HP:0002779)	1.99423354
66	Mesangial abnormality (HP:0001966)	1.99152203
67	Large for gestational age (HP:0001520)	1.97993598
68	Nuclear cataract (HP:0100018)	1.97959929
69	Hyperventilation (HP:0002883)	1.96996203
70	Pelvic girdle muscle weakness (HP:0003749)	1.96748773
71	Cystic liver disease (HP:0006706)	1.96471668
72	Hemiparesis (HP:0001269)	1.94998358
73	Keratoconjunctivitis (HP:0001096)	1.93279252
74	Mixed hearing impairment (HP:0000410)	1.93084240
75	Hypoplastic ischia (HP:0003175)	1.89395770
76	Abnormality of the aortic arch (HP:0012303)	1.88866904
77	Abnormality of the nasal mucosa (HP:0000433)	1.86429192
78	Premature skin wrinkling (HP:0100678)	1.86405265
79	Abnormality of permanent molar morphology (HP:0011071)	1.85834155
80	Abnormality of the dental root (HP:0006486)	1.85834155
81	Taurodontia (HP:0000679)	1.85834155
82	Congenital stationary night blindness (HP:0007642)	1.84831294
83	Hyperphosphaturia (HP:0003109)	1.83101758
84	Decreased central vision (HP:0007663)	1.82525091
85	Hypoplasia of the pons (HP:0012110)	1.81634082
86	Polyphagia (HP:0002591)	1.80763986
87	Congenital hepatic fibrosis (HP:0002612)	1.80672184
88	Increased connective tissue (HP:0009025)	1.80569149
89	Abnormality of the hip-girdle musculature (HP:0001445)	1.78380813
90	Abnormality of the musculature of the pelvis (HP:0001469)	1.78380813
91	Abnormality of the dental pulp (HP:0006479)	1.77419028
92	Abnormality of molar (HP:0011077)	1.76524239
93	Abnormality of molar morphology (HP:0011070)	1.76524239
94	Sex reversal (HP:0012245)	1.75020396
95	Abnormal sex determination (HP:0012244)	1.75020396
96	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.71621374
97	Bronchiectasis (HP:0002110)	1.71425442
98	Abnormality of the vitreous humor (HP:0004327)	1.70483703
99	Type I diabetes mellitus (HP:0100651)	1.70426915
100	Synostosis of carpal bones (HP:0005048)	1.68387268

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP2K7	5.05064826
2	TESK1	4.47337529
3	MAP3K4	4.42842052
4	PNCK	4.15909991
5	MAP3K6	3.81690869
6	PLK4	3.76968164
7	DAPK2	3.57686739
8	MAPK15	2.99376341
9	DDR2	2.96292394
10	PIK3CG	2.73375699
11	CDK12	2.56217832
12	MAP4K2	2.50516685
13	PLK2	2.45978316
14	INSRR	2.24542929
15	PINK1	2.21858945
16	MAP2K4	2.08531684
17	GRK7	2.00206734
18	FRK	1.82347326
19	STK38	1.73803231
20	TSSK6	1.73318438
21	CAMK1G	1.48354719
22	IRAK3	1.31902902
23	MAP2K6	1.30237430
24	MUSK	1.22195652
25	ERBB2	1.21713719
26	ADRBK2	1.21542871
27	ROCK1	1.21495800
28	PRKD3	1.06052833
29	KIT	1.00638596
30	CASK	0.99138423
31	BRD4	0.87687563
32	PAK3	0.83465164
33	PTK2B	0.82843440
34	PASK	0.79988803
35	CAMK2D	0.79188737
36	BMPR1B	0.77725665
37	LATS2	0.76825162
38	STK38L	0.73374523
39	KSR2	0.72371969
40	PDPK1	0.70508318
41	PRKAA2	0.69820776
42	RPS6KA2	0.69176034
43	DAPK3	0.66265003
44	WNK4	0.66133637
45	DYRK3	0.64449485
46	MAP3K5	0.63668020
47	RET	0.63420632
48	PRKCG	0.62083358
49	NEK6	0.60579621
50	CAMKK2	0.59301504
51	PRKCE	0.54074126
52	PDK1	0.53959420
53	CAMK1D	0.52019505
54	RPS6KA1	0.51312425
55	DAPK1	0.50901484
56	CDK7	0.50484600
57	GSK3B	0.47737122
58	MAPKAPK3	0.44794381
59	WNK1	0.44609536
60	NTRK3	0.44427581
61	ADRBK1	0.42781645
62	ZAK	0.41210448
63	CDK3	0.40790383
64	PRKACG	0.39646622
65	PRKG1	0.38815026
66	MST1R	0.38426345
67	GRK1	0.38132169
68	PRKG2	0.37616606
69	CAMK1	0.37150566
70	CDK5	0.36509827
71	PRKACA	0.36500885
72	CAMK2A	0.35920959
73	NTRK2	0.35782430
74	VRK1	0.35754963
75	STK10	0.34898913
76	MAP2K2	0.34463598
77	MAPK1	0.32660864
78	MAPK9	0.31643045
79	MAPK14	0.31630690
80	ACVR1B	0.30336632
81	UHMK1	0.30149996
82	RPS6KA6	0.28540511
83	PRKCI	0.27021396
84	EPHA2	0.26929661
85	PRKCA	0.26782189
86	MAPK8	0.26245800
87	MARK1	0.26219415
88	RPS6KA3	0.25248222
89	TRPM7	0.24135447
90	MAP3K2	0.23889703
91	MAP3K1	0.23517900
92	RPS6KC1	0.22881096
93	RPS6KL1	0.22881096
94	MST4	0.22265228
95	AKT1	0.21948770
96	MINK1	0.21539028
97	MTOR	0.20597803
98	SIK2	0.20539355
99	PRKAA1	0.20531282
100	PRKCB	0.20407328

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	5.29461854
2	Renin-angiotensin system_Homo sapiens_hsa04614	4.39591691
3	Butanoate metabolism_Homo sapiens_hsa00650	3.28224616
4	Tryptophan metabolism_Homo sapiens_hsa00380	3.01268936
5	Olfactory transduction_Homo sapiens_hsa04740	3.00153009
6	Fatty acid biosynthesis_Homo sapiens_hsa00061	2.84521859
7	Renin secretion_Homo sapiens_hsa04924	2.48117665
8	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.34683705
9	Arginine and proline metabolism_Homo sapiens_hsa00330	2.05779116
10	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	2.05279399
11	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.89017916
12	Type II diabetes mellitus_Homo sapiens_hsa04930	1.88137172
13	Salivary secretion_Homo sapiens_hsa04970	1.81627659
14	Taste transduction_Homo sapiens_hsa04742	1.78964449
15	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.67527127
16	Nicotine addiction_Homo sapiens_hsa05033	1.61397507
17	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.58285195
18	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.57624847
19	Calcium signaling pathway_Homo sapiens_hsa04020	1.56093338
20	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.45050170
21	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.39741255
22	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.31375270
23	Fatty acid degradation_Homo sapiens_hsa00071	1.29940044
24	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.27544855
25	Circadian entrainment_Homo sapiens_hsa04713	1.26112389
26	cAMP signaling pathway_Homo sapiens_hsa04024	1.24053975
27	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.20383875
28	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	1.17298432
29	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.16687235
30	Cardiac muscle contraction_Homo sapiens_hsa04260	1.07549915
31	Circadian rhythm_Homo sapiens_hsa04710	1.05371010
32	Insulin secretion_Homo sapiens_hsa04911	1.04551632
33	Sulfur relay system_Homo sapiens_hsa04122	1.04422543
34	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.99343077
35	Serotonergic synapse_Homo sapiens_hsa04726	0.99175210
36	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.98550488
37	beta-Alanine metabolism_Homo sapiens_hsa00410	0.98444781
38	Morphine addiction_Homo sapiens_hsa05032	0.98119542
39	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.96769466
40	Phototransduction_Homo sapiens_hsa04744	0.95992092
41	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.94882657
42	Fatty acid metabolism_Homo sapiens_hsa01212	0.94511544
43	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.94363128
44	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.94123927
45	Phenylalanine metabolism_Homo sapiens_hsa00360	0.91438898
46	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.88350905
47	Chemical carcinogenesis_Homo sapiens_hsa05204	0.88306074
48	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.86318068
49	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.86029314
50	GABAergic synapse_Homo sapiens_hsa04727	0.83876583
51	Type I diabetes mellitus_Homo sapiens_hsa04940	0.83628095
52	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.79231382
53	Cocaine addiction_Homo sapiens_hsa05030	0.77927055
54	PPAR signaling pathway_Homo sapiens_hsa03320	0.77427390
55	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.76768076
56	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.75503132
57	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.74516590
58	Caffeine metabolism_Homo sapiens_hsa00232	0.71406700
59	Retinol metabolism_Homo sapiens_hsa00830	0.69802658
60	Insulin resistance_Homo sapiens_hsa04931	0.66100107
61	Amphetamine addiction_Homo sapiens_hsa05031	0.61537412
62	Dopaminergic synapse_Homo sapiens_hsa04728	0.61077937
63	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.60793531
64	Collecting duct acid secretion_Homo sapiens_hsa04966	0.59168457
65	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.58704166
66	Peroxisome_Homo sapiens_hsa04146	0.58200062
67	Mineral absorption_Homo sapiens_hsa04978	0.57525686
68	Allograft rejection_Homo sapiens_hsa05330	0.57121470
69	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.57011870
70	Legionellosis_Homo sapiens_hsa05134	0.56640727
71	Lysine degradation_Homo sapiens_hsa00310	0.56082260
72	ABC transporters_Homo sapiens_hsa02010	0.55763148
73	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.55094543
74	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.54633093
75	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.54337397
76	Estrogen signaling pathway_Homo sapiens_hsa04915	0.51522321
77	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.51251240
78	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.49028474
79	Endocytosis_Homo sapiens_hsa04144	0.49027743
80	Antigen processing and presentation_Homo sapiens_hsa04612	0.48842904
81	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.47692639
82	Purine metabolism_Homo sapiens_hsa00230	0.45505135
83	Tyrosine metabolism_Homo sapiens_hsa00350	0.44424397
84	Propanoate metabolism_Homo sapiens_hsa00640	0.42580267
85	Arginine biosynthesis_Homo sapiens_hsa00220	0.37538938
86	Graft-versus-host disease_Homo sapiens_hsa05332	0.36493368
87	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.33904028
88	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.31921413
89	Tight junction_Homo sapiens_hsa04530	0.31899966
90	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.30817091
91	Regulation of autophagy_Homo sapiens_hsa04140	0.30781664
92	Glutamatergic synapse_Homo sapiens_hsa04724	0.30132090
93	Galactose metabolism_Homo sapiens_hsa00052	0.29213065
94	Fat digestion and absorption_Homo sapiens_hsa04975	0.27232944
95	Metabolic pathways_Homo sapiens_hsa01100	0.26631521
96	Alcoholism_Homo sapiens_hsa05034	0.25975910
97	Cholinergic synapse_Homo sapiens_hsa04725	0.25616025
98	Adherens junction_Homo sapiens_hsa04520	0.25222188
99	FoxO signaling pathway_Homo sapiens_hsa04068	0.25141729
100	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.23604848

VN2R17P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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