VN2R19P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA methylation involved in gamete generation (GO:0043046)7.02440285
2centriole replication (GO:0007099)5.97230463
3regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)5.58983984
4regulation of mitotic spindle checkpoint (GO:1903504)5.58983984
5centriole assembly (GO:0098534)5.34120150
6resolution of meiotic recombination intermediates (GO:0000712)5.27917379
7male meiosis (GO:0007140)4.88378312
8gene silencing by RNA (GO:0031047)4.45017257
9regulation of meiosis I (GO:0060631)4.36880141
10meiotic chromosome segregation (GO:0045132)4.29756394
11lactate metabolic process (GO:0006089)4.27974864
12meiotic cell cycle (GO:0051321)4.24999635
13regulation of spindle organization (GO:0090224)4.19703347
14metaphase plate congression (GO:0051310)4.18465172
15mitotic metaphase plate congression (GO:0007080)4.11811747
16positive regulation of mitotic sister chromatid separation (GO:1901970)4.10672452
17positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.10672452
18positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.10672452
19regulation of mitotic spindle organization (GO:0060236)4.09045003
20DNA ligation (GO:0006266)4.07605086
21CENP-A containing nucleosome assembly (GO:0034080)4.05701313
22male meiosis I (GO:0007141)3.95961010
23histone H2A acetylation (GO:0043968)3.95457253
24chromatin remodeling at centromere (GO:0031055)3.94907862
25meiotic nuclear division (GO:0007126)3.90684680
26negative regulation of translation, ncRNA-mediated (GO:0040033)3.88722263
27regulation of translation, ncRNA-mediated (GO:0045974)3.88722263
28negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.88722263
29regulation of DNA endoreduplication (GO:0032875)3.87166331
30rRNA catabolic process (GO:0016075)3.86681039
31synapsis (GO:0007129)3.83789898
32negative regulation of DNA-dependent DNA replication (GO:2000104)3.75877683
33regulation of spindle checkpoint (GO:0090231)3.72732806
34establishment of chromosome localization (GO:0051303)3.67792265
35DNA alkylation (GO:0006305)3.59260824
36DNA methylation (GO:0006306)3.59260824
37female gamete generation (GO:0007292)3.56688279
38regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.53685071
39positive regulation of histone H3-K4 methylation (GO:0051571)3.52699186
40ncRNA catabolic process (GO:0034661)3.48377529
41retinal cone cell development (GO:0046549)3.43428208
42pyrimidine-containing compound transmembrane transport (GO:0072531)3.42984836
43maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.41701858
44histone exchange (GO:0043486)3.39756515
45positive regulation of chromosome segregation (GO:0051984)3.36608340
46mitotic sister chromatid segregation (GO:0000070)3.33512519
47centrosome organization (GO:0051297)3.32438298
48recombinational repair (GO:0000725)3.31940223
49mitotic chromosome condensation (GO:0007076)3.27909729
50intraciliary transport (GO:0042073)3.27244122
51protein localization to kinetochore (GO:0034501)3.25845369
52meiosis I (GO:0007127)3.25629186
53regulation of chromosome segregation (GO:0051983)3.22789257
54regulation of sister chromatid cohesion (GO:0007063)3.22184822
55acrosome assembly (GO:0001675)3.20517856
56DNA replication-independent nucleosome organization (GO:0034724)3.19650498
57DNA replication-independent nucleosome assembly (GO:0006336)3.19650498
58regulation of mitotic sister chromatid separation (GO:0010965)3.17644007
59regulation of mitotic sister chromatid segregation (GO:0033047)3.17644007
60regulation of sister chromatid segregation (GO:0033045)3.17644007
61spindle checkpoint (GO:0031577)3.17357312
62replication fork processing (GO:0031297)3.14516859
63regulation of alternative mRNA splicing, via spliceosome (GO:0000381)3.13285106
64attachment of spindle microtubules to kinetochore (GO:0008608)3.13084985
65histone H3-K9 methylation (GO:0051567)3.11488536
66chromosome organization involved in meiosis (GO:0070192)3.10822217
67double-strand break repair via homologous recombination (GO:0000724)3.10751924
68nucleotide-excision repair, DNA gap filling (GO:0006297)3.09249126
69gonadal mesoderm development (GO:0007506)3.07545046
70regulation of mitotic metaphase/anaphase transition (GO:0030071)3.06615137
71regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.06615137
72nucleotide transmembrane transport (GO:1901679)3.05814352
73sister chromatid segregation (GO:0000819)3.04619350
74mismatch repair (GO:0006298)3.04500925
75meiotic cell cycle process (GO:1903046)3.04473894
76somatic diversification of immune receptors via somatic mutation (GO:0002566)3.02887828
77somatic hypermutation of immunoglobulin genes (GO:0016446)3.02887828
78regulation of histone H3-K9 methylation (GO:0051570)3.02777671
79microtubule organizing center organization (GO:0031023)3.02699457
80reciprocal meiotic recombination (GO:0007131)3.02415974
81reciprocal DNA recombination (GO:0035825)3.02415974
82mitotic spindle checkpoint (GO:0071174)2.98789360
83chromosome segregation (GO:0007059)2.98379519
84negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.98296484
85negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.98296484
86negative regulation of mitotic sister chromatid segregation (GO:0033048)2.98296484
87negative regulation of mitotic sister chromatid separation (GO:2000816)2.98296484
88negative regulation of sister chromatid segregation (GO:0033046)2.98296484
89L-fucose catabolic process (GO:0042355)2.96224594
90fucose catabolic process (GO:0019317)2.96224594
91L-fucose metabolic process (GO:0042354)2.96224594
92protein K6-linked ubiquitination (GO:0085020)2.94639858
93protein K11-linked deubiquitination (GO:0035871)2.94536234
94DNA double-strand break processing (GO:0000729)2.91727179
95regulation of centrosome cycle (GO:0046605)2.89484066
96synaptonemal complex assembly (GO:0007130)2.88743843
97negative regulation of chromosome segregation (GO:0051985)2.88124083
98nuclear pore complex assembly (GO:0051292)2.87345367
99DNA methylation or demethylation (GO:0044728)2.87034852
100piRNA metabolic process (GO:0034587)10.0026763

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.91056511
2SALL1_21062744_ChIP-ChIP_HESCs_Human3.95910155
3IGF1R_20145208_ChIP-Seq_DFB_Human3.95185572
4EZH2_22144423_ChIP-Seq_EOC_Human3.93926502
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.80000252
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.31095932
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.91184622
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.75709372
9TAF15_26573619_Chip-Seq_HEK293_Human2.70155965
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.65753498
11GBX2_23144817_ChIP-Seq_PC3_Human2.65417787
12ZNF274_21170338_ChIP-Seq_K562_Hela2.59567228
13VDR_22108803_ChIP-Seq_LS180_Human2.04250729
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.01583295
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.00240573
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.96962635
17POU3F2_20337985_ChIP-ChIP_501MEL_Human1.96827150
18PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.94674626
19PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.85006023
20CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.84729738
21EWS_26573619_Chip-Seq_HEK293_Human1.80228606
22TP63_19390658_ChIP-ChIP_HaCaT_Human1.76982573
23CTBP1_25329375_ChIP-Seq_LNCAP_Human1.75844665
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.69565781
25CTBP2_25329375_ChIP-Seq_LNCAP_Human1.65767019
26EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.62159197
27FLI1_27457419_Chip-Seq_LIVER_Mouse1.60760852
28MYC_18940864_ChIP-ChIP_HL60_Human1.59506289
29HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.58984875
30E2F7_22180533_ChIP-Seq_HELA_Human1.56158533
31NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.55794777
32GABP_17652178_ChIP-ChIP_JURKAT_Human1.53630373
33AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.52859171
34GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.51645753
35ZFP57_27257070_Chip-Seq_ESCs_Mouse1.51265559
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.50849597
37HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.50630716
38ELK1_19687146_ChIP-ChIP_HELA_Human1.50476720
39AR_21909140_ChIP-Seq_LNCAP_Human1.49901043
40P300_19829295_ChIP-Seq_ESCs_Human1.48786795
41ER_23166858_ChIP-Seq_MCF-7_Human1.45894879
42PADI4_21655091_ChIP-ChIP_MCF-7_Human1.44220257
43UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.43182442
44TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39614930
45POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.39614930
46SMAD4_21799915_ChIP-Seq_A2780_Human1.38838730
47KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.37298039
48FOXP3_21729870_ChIP-Seq_TREG_Human1.37030676
49IRF1_19129219_ChIP-ChIP_H3396_Human1.36114894
50EZH2_27294783_Chip-Seq_NPCs_Mouse1.35061081
51PCGF2_27294783_Chip-Seq_ESCs_Mouse1.32581044
52HTT_18923047_ChIP-ChIP_STHdh_Human1.32134299
53ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.32121852
54FUS_26573619_Chip-Seq_HEK293_Human1.27280272
55CREB1_15753290_ChIP-ChIP_HEK293T_Human1.25160302
56VDR_23849224_ChIP-Seq_CD4+_Human1.25044403
57MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.21925819
58E2F1_21310950_ChIP-Seq_MCF-7_Human1.20076705
59RNF2_27304074_Chip-Seq_NSC_Mouse1.19832398
60BCAT_22108803_ChIP-Seq_LS180_Human1.19769150
61TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.16819785
62TCF4_23295773_ChIP-Seq_U87_Human1.15127426
63MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.13042514
64GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.12064507
65BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.11822291
66STAT3_23295773_ChIP-Seq_U87_Human1.10270660
67MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.09414793
68RUNX2_22187159_ChIP-Seq_PCA_Human1.09338677
69FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.09006121
70PIAS1_25552417_ChIP-Seq_VCAP_Human1.06484970
71CBX2_27304074_Chip-Seq_ESCs_Mouse1.06331871
72CBP_20019798_ChIP-Seq_JUKART_Human1.04477253
73IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.04477253
74OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03903318
75NANOG_18555785_Chip-Seq_ESCs_Mouse1.02988978
76POU5F1_16153702_ChIP-ChIP_HESCs_Human1.02651170
77AR_25329375_ChIP-Seq_VCAP_Human1.01152387
78NANOG_19829295_ChIP-Seq_ESCs_Human1.01137382
79SOX2_19829295_ChIP-Seq_ESCs_Human1.01137382
80PRDM14_20953172_ChIP-Seq_ESCs_Human1.00968869
81CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.00650273
82SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99097977
83SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.98958942
84ETS1_20019798_ChIP-Seq_JURKAT_Human0.98723489
85CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.97912304
86CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.97462515
87PCGF2_27294783_Chip-Seq_NPCs_Mouse0.97424562
88TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96943274
89FOXM1_26456572_ChIP-Seq_MCF-7_Human0.96723098
90PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.96305813
91FLI1_21867929_ChIP-Seq_TH2_Mouse0.95167821
92TOP2B_26459242_ChIP-Seq_MCF-7_Human0.94519640
93BMI1_23680149_ChIP-Seq_NPCS_Mouse0.93868668
94RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.92884928
95TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92604483
96TBX3_20139965_ChIP-Seq_MESCs_Mouse0.91517152
97SUZ12_27294783_Chip-Seq_NPCs_Mouse0.91210700
98TBX3_20139965_ChIP-Seq_ESCs_Mouse0.90642928
99CRX_20693478_ChIP-Seq_RETINA_Mouse0.90206339
100P53_22387025_ChIP-Seq_ESCs_Mouse0.90191085

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation6.55398659
2MP0003718_maternal_effect4.64920803
3MP0008057_abnormal_DNA_replication3.92291385
4MP0010094_abnormal_chromosome_stability3.84932285
5MP0006292_abnormal_olfactory_placode3.40475056
6MP0003693_abnormal_embryo_hatching3.21856282
7MP0003880_abnormal_central_pattern2.98338165
8MP0008058_abnormal_DNA_repair2.92948630
9MP0003195_calcinosis2.48818090
10MP0008789_abnormal_olfactory_epithelium2.24878877
11MP0001929_abnormal_gametogenesis2.03025670
12MP0003121_genomic_imprinting2.01658237
13MP0005395_other_phenotype2.00151413
14MP0003111_abnormal_nucleus_morphology1.99633579
15MP0002210_abnormal_sex_determination1.99518992
16MP0003077_abnormal_cell_cycle1.99006687
17MP0002102_abnormal_ear_morphology1.95522251
18MP0003890_abnormal_embryonic-extraembry1.84530045
19MP0002938_white_spotting1.80751962
20MP0008932_abnormal_embryonic_tissue1.73345620
21MP0005394_taste/olfaction_phenotype1.70673932
22MP0005499_abnormal_olfactory_system1.70673932
23MP0003787_abnormal_imprinting1.66704034
24MP0006072_abnormal_retinal_apoptosis1.63362920
25MP0000653_abnormal_sex_gland1.62294394
26MP0009780_abnormal_chondrocyte_physiolo1.62058040
27MP0002234_abnormal_pharynx_morphology1.53338904
28MP0001145_abnormal_male_reproductive1.52990130
29MP0005551_abnormal_eye_electrophysiolog1.51985917
30MP0003698_abnormal_male_reproductive1.48945243
31MP0003122_maternal_imprinting1.48252798
32MP0002139_abnormal_hepatobiliary_system1.46791147
33MP0005645_abnormal_hypothalamus_physiol1.44412049
34MP0010307_abnormal_tumor_latency1.39261655
35MP0004957_abnormal_blastocyst_morpholog1.39041284
36MP0001984_abnormal_olfaction1.37973836
37MP0002127_abnormal_cardiovascular_syste1.34439227
38MP0010234_abnormal_vibrissa_follicle1.31497549
39MP0005646_abnormal_pituitary_gland1.29399327
40MP0008007_abnormal_cellular_replicative1.29357149
41MP0006036_abnormal_mitochondrial_physio1.27643440
42MP0010368_abnormal_lymphatic_system1.23243873
43MP0004043_abnormal_pH_regulation1.17436274
44MP0005253_abnormal_eye_physiology1.15681073
45MP0008995_early_reproductive_senescence1.14886826
46MP0006035_abnormal_mitochondrial_morpho1.11293693
47MP0002233_abnormal_nose_morphology1.08044481
48MP0001119_abnormal_female_reproductive1.05417279
49MP0010678_abnormal_skin_adnexa1.04476079
50MP0002161_abnormal_fertility/fecundity1.03367561
51MP0001293_anophthalmia1.03212172
52MP0000631_abnormal_neuroendocrine_gland1.02234737
53MP0001986_abnormal_taste_sensitivity1.02225961
54MP0003699_abnormal_female_reproductive1.00721611
55MP0005083_abnormal_biliary_tract1.00464579
56MP0008775_abnormal_heart_ventricle0.95653492
57MP0000427_abnormal_hair_cycle0.93126974
58MP0005647_abnormal_sex_gland0.89410228
59MP0000383_abnormal_hair_follicle0.89199938
60MP0004215_abnormal_myocardial_fiber0.88745355
61MP0005167_abnormal_blood-brain_barrier0.87073733
62MP0005410_abnormal_fertilization0.85878068
63MP0008872_abnormal_physiological_respon0.85109269
64MP0002282_abnormal_trachea_morphology0.82704858
65MP0003943_abnormal_hepatobiliary_system0.81849446
66MP0005391_vision/eye_phenotype0.78466957
67MP0000428_abnormal_craniofacial_morphol0.78191311
68MP0004145_abnormal_muscle_electrophysio0.77517741
69MP0001697_abnormal_embryo_size0.76281035
70MP0010030_abnormal_orbit_morphology0.75776346
71MP0006276_abnormal_autonomic_nervous0.75257998
72MP0004134_abnormal_chest_morphology0.74800826
73MP0003183_abnormal_peptide_metabolism0.73543766
74MP0003937_abnormal_limbs/digits/tail_de0.73387563
75MP0002160_abnormal_reproductive_system0.71646696
76MP0004147_increased_porphyrin_level0.70128144
77MP0001486_abnormal_startle_reflex0.69470001
78MP0003119_abnormal_digestive_system0.69374453
79MP0000778_abnormal_nervous_system0.69095875
80MP0005174_abnormal_tail_pigmentation0.65675405
81MP0003786_premature_aging0.63920064
82MP0002090_abnormal_vision0.61745746
83MP0004885_abnormal_endolymph0.60921928
84MP0002272_abnormal_nervous_system0.59777052
85MP0005389_reproductive_system_phenotype0.58550424
86MP0002928_abnormal_bile_duct0.57692642
87MP0005195_abnormal_posterior_eye0.57257334
88MP0010386_abnormal_urinary_bladder0.56948364
89MP0009745_abnormal_behavioral_response0.56832898
90MP0002876_abnormal_thyroid_physiology0.56345466
91MP0003936_abnormal_reproductive_system0.56160972
92MP0000647_abnormal_sebaceous_gland0.55973017
93MP0005380_embryogenesis_phenotype0.55781948
94MP0001672_abnormal_embryogenesis/_devel0.55781948
95MP0002396_abnormal_hematopoietic_system0.55472083
96MP0000230_abnormal_systemic_arterial0.54818263
97MP0005187_abnormal_penis_morphology0.54598262
98MP0000015_abnormal_ear_pigmentation0.54275164
99MP0003935_abnormal_craniofacial_develop0.53981489
100MP0005397_hematopoietic_system_phenotyp0.53716763

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.12272354
2Volvulus (HP:0002580)4.93967866
3Chromsome breakage (HP:0040012)4.71401402
4Abnormality of the ileum (HP:0001549)3.77171970
5Meckel diverticulum (HP:0002245)3.62035516
6Aplasia/Hypoplasia of the uvula (HP:0010293)3.59930233
7Gonadotropin excess (HP:0000837)3.50561945
8Tubulointerstitial nephritis (HP:0001970)3.39381284
9Abnormality of the labia minora (HP:0012880)3.21850834
10Median cleft lip (HP:0000161)3.15958687
11Papillary thyroid carcinoma (HP:0002895)3.03401636
12Abnormality of chromosome stability (HP:0003220)2.98669823
13Ectopic kidney (HP:0000086)2.89926779
14Abnormality of the preputium (HP:0100587)2.89063146
15Pendular nystagmus (HP:0012043)2.87429503
16Colon cancer (HP:0003003)2.87197234
17Nephroblastoma (Wilms tumor) (HP:0002667)2.86162301
18Attenuation of retinal blood vessels (HP:0007843)2.85061894
19Sloping forehead (HP:0000340)2.74115424
20Duodenal stenosis (HP:0100867)2.72211054
21Small intestinal stenosis (HP:0012848)2.72211054
22Embryonal renal neoplasm (HP:0011794)2.66809038
23Medial flaring of the eyebrow (HP:0010747)2.66772250
24Abnormal tarsal ossification (HP:0008369)2.64288091
25Chronic hepatic failure (HP:0100626)2.58096933
26Molar tooth sign on MRI (HP:0002419)2.57843995
27Abnormality of midbrain morphology (HP:0002418)2.57843995
28Intestinal atresia (HP:0011100)2.52472709
29Nephronophthisis (HP:0000090)2.52016931
30Retinal atrophy (HP:0001105)2.47093573
31Facial hemangioma (HP:0000329)2.46360305
32Abnormality of the duodenum (HP:0002246)2.42502090
33Large for gestational age (HP:0001520)2.40449945
34Type II lissencephaly (HP:0007260)2.34169130
35Short middle phalanx of the 5th finger (HP:0004220)2.32899508
36Abnormality of the renal medulla (HP:0100957)2.29130635
37Abnormal foot bone ossification (HP:0010675)2.27414295
38Broad distal phalanx of finger (HP:0009836)2.27258118
39Pancreatic islet-cell hyperplasia (HP:0004510)2.25670660
40Supernumerary spleens (HP:0009799)2.25282710
41Rhabdomyosarcoma (HP:0002859)2.23227031
42Decreased central vision (HP:0007663)2.19403837
43Triphalangeal thumb (HP:0001199)2.18956109
44Clubbing of toes (HP:0100760)2.17150885
45Abnormality of abdominal situs (HP:0011620)2.16766756
46Abdominal situs inversus (HP:0003363)2.16766756
47Impulsivity (HP:0100710)2.16583768
48Tented upper lip vermilion (HP:0010804)2.15607386
49Congenital primary aphakia (HP:0007707)2.11643228
50Short tibia (HP:0005736)2.11353218
51Small hand (HP:0200055)2.11129642
52Hypoplasia of the fovea (HP:0007750)2.10904243
53Aplasia/Hypoplasia of the fovea (HP:0008060)2.10904243
54Aplasia/Hypoplasia of the tibia (HP:0005772)2.10327118
55Severe visual impairment (HP:0001141)2.07300139
56Gait imbalance (HP:0002141)2.06127844
57Pancreatic fibrosis (HP:0100732)2.05119449
58Thyroid carcinoma (HP:0002890)2.04763591
59Abnormality of the carotid arteries (HP:0005344)2.02357779
60Abnormality of endocrine pancreas physiology (HP:0012093)2.02041463
61Abnormality of the pancreatic islet cells (HP:0006476)2.02041463
62Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.00716568
63Bony spicule pigmentary retinopathy (HP:0007737)1.99646561
64Septo-optic dysplasia (HP:0100842)1.98551884
65Optic nerve hypoplasia (HP:0000609)1.98241684
66Pancreatic cysts (HP:0001737)1.97827951
67Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.94787720
68Cerebellar dysplasia (HP:0007033)1.94676138
69Occipital encephalocele (HP:0002085)1.93922913
70Febrile seizures (HP:0002373)1.93788989
71Microvesicular hepatic steatosis (HP:0001414)1.91563814
72Stillbirth (HP:0003826)1.89179689
73Barrel-shaped chest (HP:0001552)1.88628916
74Acute lymphatic leukemia (HP:0006721)1.88484902
75Aganglionic megacolon (HP:0002251)1.86433204
76Dynein arm defect of respiratory motile cilia (HP:0012255)1.86219902
77Absent/shortened dynein arms (HP:0200106)1.86219902
78Astigmatism (HP:0000483)1.85559384
79Genital tract atresia (HP:0001827)1.84565067
80Absent rod-and cone-mediated responses on ERG (HP:0007688)1.84321747
81Thin upper lip vermilion (HP:0000219)1.83953597
82Abnormal rod and cone electroretinograms (HP:0008323)1.83282352
83Medulloblastoma (HP:0002885)1.82974670
84Abnormality of the phalanges of the 5th finger (HP:0004213)1.81474654
85Nephrogenic diabetes insipidus (HP:0009806)1.80820372
86Dyschromatopsia (HP:0007641)1.79260793
87Hypoplastic iliac wings (HP:0002866)1.78832077
88Gastrointestinal atresia (HP:0002589)1.78520980
89Tubulointerstitial abnormality (HP:0001969)1.78145999
90Polydipsia (HP:0001959)1.77913715
91Abnormal drinking behavior (HP:0030082)1.77913715
92Horizontal nystagmus (HP:0000666)1.77139079
93Oligodactyly (hands) (HP:0001180)1.76259960
94Ependymoma (HP:0002888)1.75904170
95Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.74822022
96Short thumb (HP:0009778)1.74386835
97Postaxial hand polydactyly (HP:0001162)1.73475100
98Glioma (HP:0009733)1.72286765
99Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.72205090
100Posterior subcapsular cataract (HP:0007787)1.71850271

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAF13.87372894
2MAP4K23.72961382
3SRPK13.70078557
4BRD43.32771541
5WNK33.25216886
6EIF2AK33.20230091
7FRK3.18318195
8TNIK2.62599602
9BMPR1B2.59309601
10BUB12.25645505
11PLK32.20507440
12MUSK2.19591084
13TRIM282.09563763
14EIF2AK12.08182678
15MAP3K41.97635929
16PLK11.93580803
17WEE11.91582091
18PNCK1.91355138
19BRSK21.78647441
20PLK41.73826637
21CCNB11.71721241
22MAP3K91.59598381
23YES11.55174389
24ACVR1B1.48041394
25NUAK11.40935917
26WNK41.39119679
27PLK21.28655994
28NEK61.25052665
29TTK1.24162450
30STK391.22757360
31TAOK31.22539552
32TSSK61.21270030
33AURKB1.12800503
34PKN11.09060960
35CSNK1G11.05893102
36VRK21.04213202
37EPHA41.01885529
38MST41.00226408
39CDK90.99089117
40CSNK1G20.96043018
41EPHB20.95519571
42MKNK10.95380367
43STK240.93750397
44CDK30.91950337
45NTRK20.89976813
46ATM0.88888561
47CDC70.83179706
48BRSK10.83179202
49ATR0.82202060
50STK30.79830523
51ARAF0.79796006
52TIE10.79577370
53MKNK20.77734913
54MINK10.77422286
55CSNK1G30.77212325
56TGFBR10.75246727
57PIK3CA0.74052358
58CHEK10.72379499
59PRKCI0.71485071
60VRK10.68262888
61CHEK20.67987640
62AURKA0.64607707
63RAF10.62460220
64STK38L0.60630657
65MARK30.58533135
66MAP2K40.57273566
67NTRK30.54131462
68CDK10.54070520
69NEK10.51394010
70CSNK1D0.48686447
71CSNK2A10.46370619
72NLK0.46129204
73FGFR20.46062285
74CSNK1E0.45682702
75TNK20.44941935
76CDK20.43568757
77DYRK1A0.43311686
78EIF2AK20.42115441
79CDK80.40660395
80CDK70.38702470
81MAP2K70.38146615
82PRKAA10.36780894
83BRAF0.36416282
84INSRR0.35453837
85PRKDC0.35278977
86OXSR10.32842905
87PIM20.32088148
88AKT30.31565931
89CSNK2A20.30544589
90MAPK130.30106812
91PAK10.29533857
92CAMK1G0.29419350
93NEK90.27582587
94NEK20.27529630
95ZAK0.25039102
96PRKG10.24774472
97PRKACA0.24278092
98WNK10.24225042
99UHMK10.23657390
100STK100.23521833

Predicted pathways (KEGG)

RankGene SetZ-score
1Homologous recombination_Homo sapiens_hsa034403.98892507
2Mismatch repair_Homo sapiens_hsa034303.96998796
3Fanconi anemia pathway_Homo sapiens_hsa034603.85112344
4Non-homologous end-joining_Homo sapiens_hsa034502.69815507
5Basal transcription factors_Homo sapiens_hsa030222.67410782
6DNA replication_Homo sapiens_hsa030302.63577882
7Base excision repair_Homo sapiens_hsa034102.57805503
8Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.54047399
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.51080260
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.49130374
11Butanoate metabolism_Homo sapiens_hsa006502.42051294
12Fatty acid elongation_Homo sapiens_hsa000622.23291633
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.16567449
14Cell cycle_Homo sapiens_hsa041102.06698569
15Oocyte meiosis_Homo sapiens_hsa041142.00888422
16Dorso-ventral axis formation_Homo sapiens_hsa043201.78593789
17Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.77443948
18Phototransduction_Homo sapiens_hsa047441.71826257
19Caffeine metabolism_Homo sapiens_hsa002321.60653665
20Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.58929503
21RNA degradation_Homo sapiens_hsa030181.58627903
22Lysine degradation_Homo sapiens_hsa003101.56978464
23RNA transport_Homo sapiens_hsa030131.55770396
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.55034679
25Nucleotide excision repair_Homo sapiens_hsa034201.49829252
26Hedgehog signaling pathway_Homo sapiens_hsa043401.43284068
27Maturity onset diabetes of the young_Homo sapiens_hsa049501.41712666
28RNA polymerase_Homo sapiens_hsa030201.41510506
29Regulation of autophagy_Homo sapiens_hsa041401.41067194
30Protein export_Homo sapiens_hsa030601.37329854
31Propanoate metabolism_Homo sapiens_hsa006401.33638902
32Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.24073432
33Circadian rhythm_Homo sapiens_hsa047101.23572280
34Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.23041678
35TGF-beta signaling pathway_Homo sapiens_hsa043501.21503822
36beta-Alanine metabolism_Homo sapiens_hsa004101.18810461
37Olfactory transduction_Homo sapiens_hsa047401.15047375
38Purine metabolism_Homo sapiens_hsa002301.07879849
39Ovarian steroidogenesis_Homo sapiens_hsa049131.03024443
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.00358743
41Taste transduction_Homo sapiens_hsa047420.92667879
42Vitamin B6 metabolism_Homo sapiens_hsa007500.90870567
43Pyrimidine metabolism_Homo sapiens_hsa002400.84751185
44p53 signaling pathway_Homo sapiens_hsa041150.82050150
45One carbon pool by folate_Homo sapiens_hsa006700.81840143
46Steroid biosynthesis_Homo sapiens_hsa001000.80631042
47Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.78923434
48Sulfur metabolism_Homo sapiens_hsa009200.78279206
49Tryptophan metabolism_Homo sapiens_hsa003800.78228580
50Histidine metabolism_Homo sapiens_hsa003400.77696064
51Fatty acid metabolism_Homo sapiens_hsa012120.75407612
52Fatty acid degradation_Homo sapiens_hsa000710.72754146
53Insulin secretion_Homo sapiens_hsa049110.72347192
54Collecting duct acid secretion_Homo sapiens_hsa049660.71622771
55Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.71070180
56Basal cell carcinoma_Homo sapiens_hsa052170.68646630
57Folate biosynthesis_Homo sapiens_hsa007900.67981230
58Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.67761665
59Spliceosome_Homo sapiens_hsa030400.66315528
60Proteasome_Homo sapiens_hsa030500.63389852
61Glutathione metabolism_Homo sapiens_hsa004800.62196111
62Pyruvate metabolism_Homo sapiens_hsa006200.61558638
63ABC transporters_Homo sapiens_hsa020100.61469438
64Pentose and glucuronate interconversions_Homo sapiens_hsa000400.61256730
65mRNA surveillance pathway_Homo sapiens_hsa030150.60689916
66Selenocompound metabolism_Homo sapiens_hsa004500.59787747
67Linoleic acid metabolism_Homo sapiens_hsa005910.56142424
68Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52889848
69Huntingtons disease_Homo sapiens_hsa050160.51325083
70Arachidonic acid metabolism_Homo sapiens_hsa005900.50811497
71Retinol metabolism_Homo sapiens_hsa008300.50217140
72Tight junction_Homo sapiens_hsa045300.49654969
73Peroxisome_Homo sapiens_hsa041460.49623123
74alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.49596943
75Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.45319398
76Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.43821848
77Serotonergic synapse_Homo sapiens_hsa047260.43310896
78Metabolic pathways_Homo sapiens_hsa011000.43178238
79Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.42782939
80Hippo signaling pathway_Homo sapiens_hsa043900.41885685
81Ether lipid metabolism_Homo sapiens_hsa005650.41074150
82Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.36972616
83Sphingolipid metabolism_Homo sapiens_hsa006000.36706969
84Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.36702794
85Cyanoamino acid metabolism_Homo sapiens_hsa004600.33398583
86Sulfur relay system_Homo sapiens_hsa041220.30426474
87Wnt signaling pathway_Homo sapiens_hsa043100.30227774
88Steroid hormone biosynthesis_Homo sapiens_hsa001400.28147495
89Circadian entrainment_Homo sapiens_hsa047130.26820860
90Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.25178593
91Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.23682857
92Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.23638790
93Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.23529087
94Gap junction_Homo sapiens_hsa045400.23161611
95Synaptic vesicle cycle_Homo sapiens_hsa047210.22860855
96Chemical carcinogenesis_Homo sapiens_hsa052040.22818551
97Glycerolipid metabolism_Homo sapiens_hsa005610.22132224
98Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.21868232
99Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.18876260
100Melanogenesis_Homo sapiens_hsa049160.17015277

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