VNN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the vanin family of proteins, which share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. This protein, like its mouse homolog, is likely a GPI-anchored cell surface molecule. The mouse protein is expressed by the perivascular thymic stromal cells and regulates migration of T-cell progenitors to the thymus. This gene lies in close proximity to, and in the same transcriptional orientation as, two other vanin genes on chromosome 6q23-q24. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)6.52874853
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.52874853
3L-phenylalanine metabolic process (GO:0006558)6.34792548
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.34792548
5aromatic amino acid family catabolic process (GO:0009074)5.89716371
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.78606812
7serine family amino acid catabolic process (GO:0009071)5.66272286
8glyoxylate metabolic process (GO:0046487)5.57844234
9epoxygenase P450 pathway (GO:0019373)5.54516495
10cysteine metabolic process (GO:0006534)5.44097659
11alpha-linolenic acid metabolic process (GO:0036109)5.42404944
12indole-containing compound catabolic process (GO:0042436)5.32333099
13indolalkylamine catabolic process (GO:0046218)5.32333099
14tryptophan catabolic process (GO:0006569)5.32333099
15amino-acid betaine metabolic process (GO:0006577)5.29047545
16uronic acid metabolic process (GO:0006063)5.21017669
17glucuronate metabolic process (GO:0019585)5.21017669
18kynurenine metabolic process (GO:0070189)5.19345100
19sulfur amino acid catabolic process (GO:0000098)5.06028930
20tryptophan metabolic process (GO:0006568)5.05458936
21bile acid biosynthetic process (GO:0006699)5.00331478
22glycine metabolic process (GO:0006544)4.94826648
23high-density lipoprotein particle remodeling (GO:0034375)4.90043136
24fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.82691998
25lysine metabolic process (GO:0006553)4.81867643
26lysine catabolic process (GO:0006554)4.81867643
27homocysteine metabolic process (GO:0050667)4.81127635
28serine family amino acid metabolic process (GO:0009069)4.72176959
29urea cycle (GO:0000050)4.67944626
30urea metabolic process (GO:0019627)4.67944626
31aromatic amino acid family metabolic process (GO:0009072)4.67809585
32urate metabolic process (GO:0046415)4.63087123
33serine family amino acid biosynthetic process (GO:0009070)4.53622226
34negative regulation of sterol transport (GO:0032372)4.52318036
35negative regulation of cholesterol transport (GO:0032375)4.52318036
36drug catabolic process (GO:0042737)4.52218566
37negative regulation of fibrinolysis (GO:0051918)4.51699689
38peptidyl-glutamic acid carboxylation (GO:0017187)4.50526037
39protein carboxylation (GO:0018214)4.50526037
40bile acid metabolic process (GO:0008206)4.50498052
41regulation of cholesterol esterification (GO:0010872)4.46992199
42reverse cholesterol transport (GO:0043691)4.38154013
43alpha-amino acid catabolic process (GO:1901606)4.33335138
44nitrogen cycle metabolic process (GO:0071941)4.33091884
45cellular ketone body metabolic process (GO:0046950)4.32799853
46regulation of triglyceride catabolic process (GO:0010896)4.31216347
47omega-hydroxylase P450 pathway (GO:0097267)4.28215905
48fibrinolysis (GO:0042730)4.22427612
49hormone catabolic process (GO:0042447)4.20498307
50drug transmembrane transport (GO:0006855)4.18546502
51regulation of protein activation cascade (GO:2000257)4.16994329
52regulation of fibrinolysis (GO:0051917)4.16972442
53protein-lipid complex remodeling (GO:0034368)4.16448055
54macromolecular complex remodeling (GO:0034367)4.16448055
55plasma lipoprotein particle remodeling (GO:0034369)4.16448055
56cellular amino acid catabolic process (GO:0009063)4.08490521
57tyrosine metabolic process (GO:0006570)4.03870275
58phospholipid efflux (GO:0033700)4.02907835
59acylglycerol homeostasis (GO:0055090)4.02641063
60triglyceride homeostasis (GO:0070328)4.02641063
61bile acid and bile salt transport (GO:0015721)4.00293990
62complement activation, alternative pathway (GO:0006957)3.98202835
63acute-phase response (GO:0006953)3.91623102
64fructose metabolic process (GO:0006000)3.91017025
65regulation of complement activation (GO:0030449)3.90639525
66benzene-containing compound metabolic process (GO:0042537)3.87033792
67carnitine metabolic process (GO:0009437)3.84862663
68negative regulation of protein activation cascade (GO:2000258)3.84793209
69vitamin transmembrane transport (GO:0035461)3.79525717
70biotin metabolic process (GO:0006768)3.77096469
71cholesterol efflux (GO:0033344)3.76500592
72plasma lipoprotein particle clearance (GO:0034381)3.75143097
73carboxylic acid catabolic process (GO:0046395)3.75025153
74organic acid catabolic process (GO:0016054)3.75025153
75folic acid metabolic process (GO:0046655)3.74258512
76complement activation (GO:0006956)3.74134782
77* pantothenate metabolic process (GO:0015939)3.74066930
78alkaloid metabolic process (GO:0009820)3.73960637
79positive regulation of lipoprotein lipase activity (GO:0051006)3.73848929
80positive regulation of triglyceride lipase activity (GO:0061365)3.73848929
81indolalkylamine metabolic process (GO:0006586)3.73305265
82protein activation cascade (GO:0072376)3.73290278
83short-chain fatty acid metabolic process (GO:0046459)3.73169246
842-oxoglutarate metabolic process (GO:0006103)3.72040031
85drug transport (GO:0015893)3.71952458
86amine catabolic process (GO:0009310)3.71830789
87cellular biogenic amine catabolic process (GO:0042402)3.71830789
88fatty acid beta-oxidation (GO:0006635)3.71385796
89ketone body metabolic process (GO:1902224)3.71229731
90heme transport (GO:0015886)3.70890848
91drug metabolic process (GO:0017144)3.70197078
92cellular glucuronidation (GO:0052695)3.70134691
93regulation of cholesterol homeostasis (GO:2000188)3.69875636
94cellular modified amino acid catabolic process (GO:0042219)3.69359901
95glutamate metabolic process (GO:0006536)3.68980171
96fat-soluble vitamin biosynthetic process (GO:0042362)3.67014149
97fatty acid oxidation (GO:0019395)3.65628061
98exogenous drug catabolic process (GO:0042738)3.64514926
99complement activation, classical pathway (GO:0006958)3.63000254
100blood coagulation, intrinsic pathway (GO:0007597)3.62457237
101flavonoid metabolic process (GO:0009812)3.61342665
102polyketide metabolic process (GO:0030638)3.61039523
103doxorubicin metabolic process (GO:0044598)3.61039523
104daunorubicin metabolic process (GO:0044597)3.61039523
105lipid oxidation (GO:0034440)3.58684278
106cholesterol homeostasis (GO:0042632)3.57737779
107regulation of bile acid biosynthetic process (GO:0070857)3.56700318
108negative regulation of hemostasis (GO:1900047)3.55665466
109negative regulation of blood coagulation (GO:0030195)3.55665466
110plasma lipoprotein particle assembly (GO:0034377)3.55061551
111L-serine metabolic process (GO:0006563)3.54791474
112sterol homeostasis (GO:0055092)3.53488097
113phenylpropanoid metabolic process (GO:0009698)3.51310343
114monocarboxylic acid catabolic process (GO:0072329)3.50903081
115fatty acid catabolic process (GO:0009062)3.50899654
116acetyl-CoA metabolic process (GO:0006084)3.49963540
117arginine metabolic process (GO:0006525)3.49949043
118S-adenosylmethionine metabolic process (GO:0046500)3.47491453
119detection of other organism (GO:0098543)3.47025394
120regulation of humoral immune response (GO:0002920)3.45935029
121negative regulation of complement activation (GO:0045916)3.45537454
122positive regulation of lipid catabolic process (GO:0050996)3.41268288
123folic acid transport (GO:0015884)3.41174661
124sulfur amino acid metabolic process (GO:0000096)3.39285148
125neutrophil activation involved in immune response (GO:0002283)3.38611341
126opsonization (GO:0008228)3.37351004
127negative regulation of coagulation (GO:0050819)3.35516924
128detection of bacterium (GO:0016045)3.31938001
129ethanol oxidation (GO:0006069)3.31613522
130oxidative demethylation (GO:0070989)3.29407693
131positive regulation of hemostasis (GO:1900048)3.26203241
132positive regulation of blood coagulation (GO:0030194)3.26203241
133detection of molecule of bacterial origin (GO:0032490)3.25559045
134very-low-density lipoprotein particle assembly (GO:0034379)3.24848825
135detection of external biotic stimulus (GO:0098581)3.22051855
136aminoglycoside antibiotic metabolic process (GO:0030647)3.18921648
137negative regulation of wound healing (GO:0061045)3.15007771
138positive regulation of coagulation (GO:0050820)3.10065755
139* acute inflammatory response (GO:0002526)3.09742253
140negative regulation of humoral immune response (GO:0002921)3.09138542
141regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.08791653
142leukocyte migration involved in inflammatory response (GO:0002523)3.08147889
143angiotensin maturation (GO:0002003)3.03024117
144macrophage activation involved in immune response (GO:0002281)3.02251999
145antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.95853559
146modulation by symbiont of host immune response (GO:0052553)2.90334460
147positive regulation by symbiont of host defense response (GO:0052509)2.90334460
148modulation by symbiont of host defense response (GO:0052031)2.90334460
149modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.90334460
150modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.90334460
151positive regulation by organism of defense response of other organism involved in symbiotic interact2.90334460
152positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.82864638
153primary alcohol catabolic process (GO:0034310)2.82412603
154antigen processing and presentation of endogenous antigen (GO:0019883)2.80553494
155detection of biotic stimulus (GO:0009595)2.80024814
156response to peptidoglycan (GO:0032494)2.79078046

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.31198757
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.37123486
3* EGR1_23403033_ChIP-Seq_LIVER_Mouse5.57539018
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.52996339
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.04993723
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.62107387
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.27185013
8IRF8_22096565_ChIP-ChIP_GC-B_Human4.23079513
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.51676245
10IRF8_21731497_ChIP-ChIP_J774_Mouse3.30685210
11BP1_19119308_ChIP-ChIP_Hs578T_Human3.23751629
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.16808121
13NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.14375861
14HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.51317587
15IRF8_27001747_Chip-Seq_BMDM_Mouse2.47596975
16SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.46041664
17FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.37853013
18Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.35683434
19TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.35255349
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.34960347
21CLOCK_20551151_ChIP-Seq_293T_Human2.21448897
22NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.19197018
23MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.04649490
24ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.1323311
25AR_21909140_ChIP-Seq_LNCAP_Human1.98308495
26ZNF263_19887448_ChIP-Seq_K562_Human1.89849677
27TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.89270413
28MYB_21317192_ChIP-Seq_ERMYB_Mouse1.89003274
29GATA1_22025678_ChIP-Seq_K562_Human1.88445745
30STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.84082545
31STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.83427129
32RARG_19884340_ChIP-ChIP_MEFs_Mouse1.73460883
33TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.70527399
34STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.70271900
35IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.68682219
36SPI1_23127762_ChIP-Seq_K562_Human1.52359700
37RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.51038143
38VDR_24787735_ChIP-Seq_THP-1_Human1.46432406
39* HNF4A_19822575_ChIP-Seq_HepG2_Human1.40159283
40RUNX_20019798_ChIP-Seq_JUKART_Human1.38597008
41BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.38014827
42GATA4_25053715_ChIP-Seq_YYC3_Human1.35591753
43FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.35575524
44LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.34452226
45KAP1_22055183_ChIP-Seq_ESCs_Mouse1.33338651
46GATA2_21666600_ChIP-Seq_HMVEC_Human1.33300506
47ESR2_21235772_ChIP-Seq_MCF-7_Human1.33102373
48SALL4_18804426_ChIP-ChIP_XEN_Mouse1.32671488
49NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.31627584
50VDR_24763502_ChIP-Seq_THP-1_Human1.30908343
51POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.30330410
52ESR1_21235772_ChIP-Seq_MCF-7_Human1.29429563
53SMAD_19615063_ChIP-ChIP_OVARY_Human1.29374441
54STAT3_1855785_ChIP-Seq_MESCs_Mouse1.29231820
55* SPI1_23547873_ChIP-Seq_NB4_Human1.29126027
56BRD4_27068464_Chip-Seq_AML-cells_Mouse1.29085813
57GATA1_19941827_ChIP-Seq_MEL_Mouse1.27895844
58SOX2_27498859_Chip-Seq_STOMACH_Mouse1.27823548
59CREB1_15753290_ChIP-ChIP_HEK293T_Human1.25431136
60PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.25423608
61SCL_19346495_ChIP-Seq_HPC-7_Human1.25078502
62LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.24639363
63STAT4_19710469_ChIP-ChIP_TH1__Mouse1.20916370
64CDX2_19796622_ChIP-Seq_MESCs_Mouse1.20715327
65FOXA2_19822575_ChIP-Seq_HepG2_Human1.20567831
66PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.17401333
67CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15703636
68VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.14467824
69PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14406332
70HTT_18923047_ChIP-ChIP_STHdh_Human1.13942082
71JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.12183440
72KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.11642216
73SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.11224887
74TP63_17297297_ChIP-ChIP_HaCaT_Human1.09515482
75GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.09072290
76CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06722549
77RXRA_24833708_ChIP-Seq_LIVER_Mouse1.06466724
78GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05475485
79GATA2_19941826_ChIP-Seq_K562_Human1.04954580
80RUNX1_22412390_ChIP-Seq_EML_Mouse1.04851836
81ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03885764
82GATA1_19941826_ChIP-Seq_K562_Human1.03333450
83E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.02896627
84TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.02820935
85* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02711257
86FOXO3_23340844_ChIP-Seq_DLD1_Human1.02648418
87FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.02253538
88EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.02232588
89GATA2_22383799_ChIP-Seq_G1ME_Mouse1.00090847
90ESR1_20079471_ChIP-ChIP_T-47D_Human0.98548009
91SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.98425605
92ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.98299355
93CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95596892
94* GATA3_26560356_Chip-Seq_TH2_Human0.94281494
95PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.93713565
96MYB_26560356_Chip-Seq_TH2_Human0.93112855
97NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.92917459
98STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.92523228
99CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92323107
100PPAR_26484153_Chip-Seq_NCI-H1993_Human0.92243249
101SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.90601900
102* RARA_24833708_ChIP-Seq_LIVER_Mouse0.88197617
103TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.87504515
104PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.84485080
105SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.84255497
106E2F1_18555785_ChIP-Seq_MESCs_Mouse0.83985989
107MYB_26560356_Chip-Seq_TH1_Human0.83574268
108GATA1_22383799_ChIP-Seq_G1ME_Mouse0.83316662
109SOX2_18692474_ChIP-Seq_MEFs_Mouse0.82544270
110NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.82421672
111ETS1_20019798_ChIP-Seq_JURKAT_Human0.81444307
112GATA3_27048872_Chip-Seq_THYMUS_Human0.80912375
113NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.80661178
114GATA6_25053715_ChIP-Seq_YYC3_Human0.80584221
115* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.79685896
116NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.79611890
117AUTS2_25519132_ChIP-Seq_293T-REX_Human0.78359944
118MAF_26560356_Chip-Seq_TH1_Human0.77743165
119MYC_18358816_ChIP-ChIP_MESCs_Mouse0.77239874
120RARB_24833708_ChIP-Seq_LIVER_Mouse0.76764070
121PU_27001747_Chip-Seq_BMDM_Mouse0.76752122
122OCT4_18692474_ChIP-Seq_MEFs_Mouse0.76432029
123TCF3_18692474_ChIP-Seq_MEFs_Mouse0.76129897
124NANOG_18555785_ChIP-Seq_MESCs_Mouse0.76093614
125CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.75777029
126PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.75245192
127SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.74524821
128CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.73655489
129NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.73345741
130TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.72795516
131ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.71399574
132TRIM28_21343339_ChIP-Seq_HEK293_Human0.70684738
133TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.69995392
134SOX17_20123909_ChIP-Seq_XEN_Mouse0.69392311
135CDX2_22108803_ChIP-Seq_LS180_Human0.69131091
136CDX2_20551321_ChIP-Seq_CACO-2_Human0.68560741
137PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.67130933
138ESR1_15608294_ChIP-ChIP_MCF-7_Human0.67117293
139MYC_18555785_ChIP-Seq_MESCs_Mouse0.66668936
140RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.66444982
141* ATF3_27146783_Chip-Seq_COLON_Human0.65687799
142BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.65660826
143SRF_21415370_ChIP-Seq_HL-1_Mouse0.64700111
144FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.64650655
145AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.64006786
146GATA3_24758297_ChIP-Seq_MCF-7_Human0.63859580
147RACK7_27058665_Chip-Seq_MCF-7_Human0.63697914
148EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.62168747
149NANOG_18692474_ChIP-Seq_MEFs_Mouse0.62128984
150GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.62070189
151SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.61830766
152KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.60945003
153FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.60567705
154PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.60366669
155GABP_17652178_ChIP-ChIP_JURKAT_Human0.59514081
156TET1_21451524_ChIP-Seq_MESCs_Mouse0.55853133
157NELFA_20434984_ChIP-Seq_ESCs_Mouse0.55041486
158BCOR_27268052_Chip-Seq_Bcells_Human0.54927936
159CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.53766616
160* SOX2_20726797_ChIP-Seq_SW620_Human0.53099930
161RAD21_21589869_ChIP-Seq_MESCs_Mouse0.52179999
162KLF4_18555785_ChIP-Seq_MESCs_Mouse0.48925300
163THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.48852331
164CEBPB_22108803_ChIP-Seq_LS180_Human0.48583339
165TAF2_19829295_ChIP-Seq_ESCs_Human0.48474216
166MYC_19030024_ChIP-ChIP_MESCs_Mouse0.48239214
167EST1_17652178_ChIP-ChIP_JURKAT_Human0.47999745
168NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.47495368

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.84548120
2MP0005360_urolithiasis7.13829917
3MP0005085_abnormal_gallbladder_physiolo5.63334342
4MP0005365_abnormal_bile_salt5.60307120
5MP0008875_abnormal_xenobiotic_pharmacok4.82115366
6MP0009840_abnormal_foam_cell3.99659062
7MP0003806_abnormal_nucleotide_metabolis3.67086927
8MP0003252_abnormal_bile_duct3.55543184
9MP0005332_abnormal_amino_acid3.34792853
10MP0010329_abnormal_lipoprotein_level3.27594076
11MP0003724_increased_susceptibility_to3.12746088
12MP0004019_abnormal_vitamin_homeostasis3.02713064
13MP0003195_calcinosis2.85236700
14MP0001666_abnormal_nutrient_absorption2.57651745
15MP0005083_abnormal_biliary_tract2.48296179
16MP0003436_decreased_susceptibility_to2.43025328
17MP0003303_peritoneal_inflammation2.27207709
18MP0009785_altered_susceptibility_to2.23370948
19MP0005451_abnormal_body_composition2.17625991
20MP0001835_abnormal_antigen_presentation2.11826898
21MP0003191_abnormal_cellular_cholesterol2.11717736
22MP0005464_abnormal_platelet_physiology2.08466595
23MP0002138_abnormal_hepatobiliary_system2.05565027
24MP0000609_abnormal_liver_physiology2.03193674
25MP0002118_abnormal_lipid_homeostasis1.96472174
26MP0002419_abnormal_innate_immunity1.93000990
27MP0009643_abnormal_urine_homeostasis1.83868150
28MP0005025_abnormal_response_to1.81413322
29MP0010155_abnormal_intestine_physiology1.76770107
30MP0003183_abnormal_peptide_metabolism1.75971046
31* MP0005319_abnormal_enzyme/_coenzyme1.74539253
32MP0006082_CNS_inflammation1.63909337
33MP0003718_maternal_effect1.63422749
34MP0001764_abnormal_homeostasis1.58958859
35MP0002148_abnormal_hypersensitivity_rea1.55038342
36MP0003186_abnormal_redox_activity1.54108591
37MP0001756_abnormal_urination1.50046226
38MP0005387_immune_system_phenotype1.49280025
39MP0001790_abnormal_immune_system1.49280025
40MP0005000_abnormal_immune_tolerance1.47739471
41MP0001800_abnormal_humoral_immune1.47406371
42MP0001845_abnormal_inflammatory_respons1.42958955
43MP0001533_abnormal_skeleton_physiology1.40761105
44MP0000685_abnormal_immune_system1.39756583
45MP0001661_extended_life_span1.38829384
46MP0002723_abnormal_immune_serum1.33349124
47MP0005584_abnormal_enzyme/coenzyme_acti1.32584842
48MP0003868_abnormal_feces_composition1.32199655
49MP0005636_abnormal_mineral_homeostasis1.28874227
50MP0005671_abnormal_response_to1.28501410
51MP0002452_abnormal_antigen_presenting1.28265863
52MP0005166_decreased_susceptibility_to1.26766705
53MP0003705_abnormal_hypodermis_morpholog1.17731075
54MP0000598_abnormal_liver_morphology1.17062808
55MP0003075_altered_response_to1.14957806
56MP0003656_abnormal_erythrocyte_physiolo1.13888807
57MP0002876_abnormal_thyroid_physiology1.12765562
58MP0003866_abnormal_defecation1.10990958
59MP0001819_abnormal_immune_cell1.10214055
60MP0002420_abnormal_adaptive_immunity1.09247947
61MP0009697_abnormal_copulation1.07652140
62MP0005395_other_phenotype1.05594060
63MP0002136_abnormal_kidney_physiology1.05254374
64MP0008260_abnormal_autophagy1.04399408
65MP0008004_abnormal_stomach_pH1.02932015
66MP0005084_abnormal_gallbladder_morpholo1.02490147
67MP0005164_abnormal_response_to1.01156857
68MP0000604_amyloidosis1.00903831
69MP0003172_abnormal_lysosome_physiology1.00539628
70MP0004043_abnormal_pH_regulation0.98405066
71MP0000465_gastrointestinal_hemorrhage0.96192954
72MP0004947_skin_inflammation0.96162974
73MP0009333_abnormal_splenocyte_physiolog0.93673243
74MP0005058_abnormal_lysosome_morphology0.93262232
75MP0002277_abnormal_respiratory_mucosa0.91347239
76MP0005670_abnormal_white_adipose0.91192879
77MP0005397_hematopoietic_system_phenotyp0.89542718
78MP0001545_abnormal_hematopoietic_system0.89542718
79MP0005408_hypopigmentation0.89206711
80MP0006036_abnormal_mitochondrial_physio0.88451127
81MP0000343_altered_response_to0.87494005
82MP0009053_abnormal_anal_canal0.87187369
83MP0003011_delayed_dark_adaptation0.86819329
84MP0003329_amyloid_beta_deposits0.86209614
85MP0000858_altered_metastatic_potential0.86195422
86MP0005647_abnormal_sex_gland0.85898739
87MP0001663_abnormal_digestive_system0.85840601
88MP0002405_respiratory_system_inflammati0.85825198
89MP0009764_decreased_sensitivity_to0.85713141
90MP0000249_abnormal_blood_vessel0.85352759
91MP0009642_abnormal_blood_homeostasis0.83872549
92MP0003878_abnormal_ear_physiology0.81765224
93MP0005377_hearing/vestibular/ear_phenot0.81765224
94MP0002998_abnormal_bone_remodeling0.80189786
95MP0000716_abnormal_immune_system0.79492706
96MP0004264_abnormal_extraembryonic_tissu0.78524946
97MP0008469_abnormal_protein_level0.78088729
98MP0003828_pulmonary_edema0.77731305
99MP0001542_abnormal_bone_strength0.73063300
100MP0006035_abnormal_mitochondrial_morpho0.71009553
101MP0002254_reproductive_system_inflammat0.70925222
102MP0009763_increased_sensitivity_to0.70214716
103MP0005376_homeostasis/metabolism_phenot0.69417241
104MP0008874_decreased_physiological_sensi0.68450105
105MP0004510_myositis0.68296629
106MP0001851_eye_inflammation0.67361868
107MP0000689_abnormal_spleen_morphology0.66881541
108MP0003879_abnormal_hair_cell0.66019199
109MP0009765_abnormal_xenobiotic_induced0.64184637
110MP0003763_abnormal_thymus_physiology0.64033608
111MP0002796_impaired_skin_barrier0.63671697
112MP0005220_abnormal_exocrine_pancreas0.63400861
113MP0004782_abnormal_surfactant_physiolog0.63394249
114MP0001765_abnormal_ion_homeostasis0.63181312
115MP0002398_abnormal_bone_marrow0.62804988
116MP0003693_abnormal_embryo_hatching0.61883989
117MP0001873_stomach_inflammation0.60078780
118MP0009384_cardiac_valve_regurgitation0.59169047
119MP0002078_abnormal_glucose_homeostasis0.57782838
120MP0010368_abnormal_lymphatic_system0.55492972
121MP0003638_abnormal_response/metabolism_0.54677586
122MP0000230_abnormal_systemic_arterial0.53918663
123MP0002971_abnormal_brown_adipose0.52794576
124MP0010234_abnormal_vibrissa_follicle0.51234191
125MP0002168_other_aberrant_phenotype0.50855144
126MP0009672_abnormal_birth_weight0.50783553
127MP0005334_abnormal_fat_pad0.50246735
128MP0001958_emphysema0.46382014
129MP0005266_abnormal_metabolism0.46377330
130MP0002135_abnormal_kidney_morphology0.44394833
131MP0000538_abnormal_urinary_bladder0.42558045
132MP0005535_abnormal_body_temperature0.41540972
133MP0008438_abnormal_cutaneous_collagen0.40568623
134MP0005666_abnormal_adipose_tissue0.39997306
135MP0005023_abnormal_wound_healing0.38006852
136MP0003953_abnormal_hormone_level0.37168208
137MP0004883_abnormal_blood_vessel0.36209281
138MP0003690_abnormal_glial_cell0.35089168
139MP0005275_abnormal_skin_tensile0.34657299
140MP0004147_increased_porphyrin_level0.34185583
141MP0009115_abnormal_fat_cell0.33380719
142MP0003300_gastrointestinal_ulcer0.32313119
143MP0004130_abnormal_muscle_cell0.32193873
144MP0002269_muscular_atrophy0.31347381
145MP0001881_abnormal_mammary_gland0.31301224
146MP0002060_abnormal_skin_morphology0.31135770
147MP0005448_abnormal_energy_balance0.30665256
148MP0005330_cardiomyopathy0.30507499
149MP0002132_abnormal_respiratory_system0.28884149
150MP0000639_abnormal_adrenal_gland0.28608199
151MP0008873_increased_physiological_sensi0.28539837
152MP0002928_abnormal_bile_duct0.27189151

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.02773720
2Hypobetalipoproteinemia (HP:0003563)5.74014181
3Xanthomatosis (HP:0000991)5.67149225
4Deep venous thrombosis (HP:0002625)5.66322234
5Intrahepatic cholestasis (HP:0001406)5.65344155
6Abnormality of monocarboxylic acid metabolism (HP:0010996)5.61520452
7Hyperglycinuria (HP:0003108)5.61272037
8Systemic lupus erythematosus (HP:0002725)5.58770895
9Hyperglycinemia (HP:0002154)5.38732748
10Abnormality of serine family amino acid metabolism (HP:0010894)5.12525624
11Abnormality of glycine metabolism (HP:0010895)5.12525624
12Hyperlipoproteinemia (HP:0010980)4.99237412
13Prolonged partial thromboplastin time (HP:0003645)4.95351305
14Recurrent gram-negative bacterial infections (HP:0005420)4.95143010
15Gout (HP:0001997)4.69556092
16Abnormality of glutamine family amino acid metabolism (HP:0010902)4.61087855
17Hyperammonemia (HP:0001987)4.44425096
18Hypolipoproteinemia (HP:0010981)4.32899240
19Abnormality of aspartate family amino acid metabolism (HP:0010899)4.10661389
20Abnormality of sulfur amino acid metabolism (HP:0004339)4.04815999
21Gingival bleeding (HP:0000225)4.02319345
22Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.90472202
23Eczematoid dermatitis (HP:0000976)3.89211080
24Abnormality of fatty-acid metabolism (HP:0004359)3.87486815
25Ketosis (HP:0001946)3.84878968
26Hypoalphalipoproteinemia (HP:0003233)3.73537645
27Abnormality of serum amino acid levels (HP:0003112)3.69823370
28Abnormality of methionine metabolism (HP:0010901)3.61950940
29Hypoglycemic coma (HP:0001325)3.52738019
30Purpura (HP:0000979)3.51744120
31Abnormality of purine metabolism (HP:0004352)3.50946022
32Epidermoid cyst (HP:0200040)3.49359172
33Fat malabsorption (HP:0002630)3.43291967
34Abnormality of nucleobase metabolism (HP:0010932)3.42242127
35Orchitis (HP:0100796)3.36305066
36Nephritis (HP:0000123)3.34584814
37Complement deficiency (HP:0004431)3.34047455
38Joint hemorrhage (HP:0005261)3.31886436
39Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.28155668
40Proximal tubulopathy (HP:0000114)3.28077447
41Recurrent abscess formation (HP:0002722)3.25258671
42Abnormality of pyrimidine metabolism (HP:0004353)3.24834337
43Abnormality of the common coagulation pathway (HP:0010990)3.24441985
44Abnormality of macrophages (HP:0004311)3.23720038
45Myositis (HP:0100614)3.21045927
46Delayed CNS myelination (HP:0002188)3.17816039
47Hyperuricemia (HP:0002149)3.16913915
48Increased purine levels (HP:0004368)3.16913915
49Optic neuritis (HP:0100653)3.14496989
50Retrobulbar optic neuritis (HP:0100654)3.14496989
51Abnormality of dicarboxylic acid metabolism (HP:0010995)3.14108965
52Dicarboxylic aciduria (HP:0003215)3.14108965
53Abnormality of the intrinsic pathway (HP:0010989)3.09752589
54Conjugated hyperbilirubinemia (HP:0002908)3.08278044
55Recurrent bacterial skin infections (HP:0005406)2.96305481
56Ketoacidosis (HP:0001993)2.95734080
57Epistaxis (HP:0000421)2.94836735
58Lethargy (HP:0001254)2.94256669
59Amyloidosis (HP:0011034)2.92231312
60Prolonged bleeding time (HP:0003010)2.89294384
61Hypercholesterolemia (HP:0003124)2.86706904
62Metabolic acidosis (HP:0001942)2.84466616
63Pulmonary embolism (HP:0002204)2.84407228
64Malnutrition (HP:0004395)2.78485468
65Menorrhagia (HP:0000132)2.74370790
66Hydroxyprolinuria (HP:0003080)2.74065314
67Abnormality of proline metabolism (HP:0010907)2.74065314
68Gastrointestinal infarctions (HP:0005244)2.69741189
69Hyperbilirubinemia (HP:0002904)2.69361521
70Irritability (HP:0000737)2.62158652
71Generalized aminoaciduria (HP:0002909)2.58279660
72Petechiae (HP:0000967)2.57837741
73Abnormal platelet volume (HP:0011876)2.57746470
74Glycosuria (HP:0003076)2.57340984
75Abnormality of urine glucose concentration (HP:0011016)2.57340984
76Abnormal cartilage morphology (HP:0002763)2.56372153
77Hemorrhage of the eye (HP:0011885)2.55124539
78Vascular calcification (HP:0004934)2.54934208
79Gangrene (HP:0100758)2.54539087
80Chronic obstructive pulmonary disease (HP:0006510)2.51376854
81Obstructive lung disease (HP:0006536)2.51376854
82Gingivitis (HP:0000230)2.50892998
83Steatorrhea (HP:0002570)2.50536692
84Joint swelling (HP:0001386)2.49619283
85Abnormality of iron homeostasis (HP:0011031)2.47960638
86Thrombophlebitis (HP:0004418)2.47195655
87Hepatocellular carcinoma (HP:0001402)2.46191392
88Increased serum ferritin (HP:0003281)2.41691077
89Nausea (HP:0002018)2.39349521
90Abnormality of complement system (HP:0005339)2.38372633
91Increased mean platelet volume (HP:0011877)2.38223012
92Alkalosis (HP:0001948)2.34312975
93Megaloblastic anemia (HP:0001889)2.33260503
94Anorexia (HP:0002039)2.31590663
95Cardiovascular calcification (HP:0011915)2.30092570
96Stomatitis (HP:0010280)2.29461083
97Spontaneous hematomas (HP:0007420)2.29330214
98Vasculitis (HP:0002633)2.28664746
99Spastic diplegia (HP:0001264)2.27899078
100Meningitis (HP:0001287)2.27650806
101Myocardial infarction (HP:0001658)2.26968495
102Keratoconjunctivitis sicca (HP:0001097)2.25928202
103Spontaneous abortion (HP:0005268)2.25681098
104Hyperglycemia (HP:0003074)2.25481905
105Brushfield spots (HP:0001088)2.24672365
106Osteomalacia (HP:0002749)2.21938859
107Encephalitis (HP:0002383)2.21515602
108Elevated erythrocyte sedimentation rate (HP:0003565)2.17552944
109Acanthocytosis (HP:0001927)2.15933910
110Skin nodule (HP:0200036)2.15865820
111Global brain atrophy (HP:0002283)2.13890697
112Vomiting (HP:0002013)2.12651901
113Ileus (HP:0002595)2.08425863
114Arterial thrombosis (HP:0004420)2.08367890
115Hemoptysis (HP:0002105)2.08359313
116Esophageal varix (HP:0002040)2.07112306
117Recurrent skin infections (HP:0001581)2.05962812
118Glomerulonephritis (HP:0000099)2.05338621
119Keratoconjunctivitis (HP:0001096)2.05094456
120Widely patent fontanelles and sutures (HP:0004492)2.04789873
121Poikilocytosis (HP:0004447)2.02935125
122Hypochromic microcytic anemia (HP:0004840)1.99021795
123Abnormal platelet function (HP:0011869)1.98607283
124Impaired platelet aggregation (HP:0003540)1.98607283
125Rickets (HP:0002748)1.98027554
126Mediastinal lymphadenopathy (HP:0100721)1.96934649
127Confusion (HP:0001289)1.96166027
128Urticaria (HP:0001025)1.95968229
129Pulmonary infiltrates (HP:0002113)1.94645239
130Abnormal enzyme/coenzyme activity (HP:0012379)1.94376258
131Abnormality of transition element cation homeostasis (HP:0011030)1.93260722
132Elevated alkaline phosphatase (HP:0003155)1.92114011
133Sensorimotor neuropathy (HP:0007141)1.92031300
134Abnormality of liposaccharide metabolism (HP:0010968)1.91749997
135Abnormality of glycosphingolipid metabolism (HP:0004343)1.91749997
136Abnormality of glycolipid metabolism (HP:0010969)1.91749997
137Urinary glycosaminoglycan excretion (HP:0003541)1.91155865
138Mucopolysacchariduria (HP:0008155)1.91155865
139Pancreatitis (HP:0001733)1.90144507
140Abnormality of mucopolysaccharide metabolism (HP:0011020)1.89360729
141Abnormality of polysaccharide metabolism (HP:0011012)1.89360729
142Abnormality of glycosaminoglycan metabolism (HP:0004371)1.89360729
143Peritonitis (HP:0002586)1.89118894
144Hypophosphatemia (HP:0002148)1.89032013
145Tetraplegia (HP:0002445)1.85128822
146Abnormality of vitamin metabolism (HP:0100508)1.83906099
147Spastic paraparesis (HP:0002313)1.82967267
148Methylmalonic aciduria (HP:0012120)1.82826022
149Nephrolithiasis (HP:0000787)1.82207833
150Enlarged kidneys (HP:0000105)1.81206748
151Cerebral edema (HP:0002181)1.80742876
152Opisthotonus (HP:0002179)1.79065748
153Hypokalemic alkalosis (HP:0001949)1.79036393
154Abnormality of alkaline phosphatase activity (HP:0004379)1.74579243
155Neonatal onset (HP:0003623)1.74294213
156Polycythemia (HP:0001901)1.73860216
157Renal cortical cysts (HP:0000803)1.72218631
158Atrioventricular block (HP:0001678)1.71396888
159Hypoglycemic seizures (HP:0002173)1.70707317
160Prolonged neonatal jaundice (HP:0006579)1.70472128
161Alopecia of scalp (HP:0002293)1.70253219
162Mitral stenosis (HP:0001718)1.69909774
163Multiple enchondromatosis (HP:0005701)1.67222148
164CNS demyelination (HP:0007305)1.67070499

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.50172767
2AKT34.30527279
3EPHA24.19990049
4BUB14.01172650
5RIPK43.86747102
6LMTK23.25458166
7WEE12.55923394
8WNK32.43298918
9PDK42.39358014
10PDK32.39358014
11FGFR42.38091799
12BLK2.34000377
13PINK12.21335469
14CSK2.11856202
15STK38L2.07724909
16IRAK42.07678591
17MAP3K142.06324690
18SIK12.03157204
19MAP4K12.01928671
20PLK42.00077964
21MST1R1.98199720
22ACVR1B1.92576364
23ZAP701.92240515
24ERN11.83365674
25PDK21.82716751
26IRAK31.80992013
27FRK1.70441680
28PRKG21.67657628
29EPHB11.67414513
30NEK11.61999181
31TSSK61.60919487
32MAP3K21.55544683
33MATK1.54260102
34EIF2AK11.51616536
35PRPF4B1.51103694
36STK161.49783222
37LATS11.48862011
38WNK41.48658047
39TAOK11.48118059
40SYK1.46506354
41FES1.43983375
42TNK21.42640540
43FGR1.42189617
44MAP3K11.41625289
45JAK31.41359138
46TRIB31.41321809
47JAK11.39577151
48PKN21.39538473
49BMPR21.39251371
50BTK1.38374282
51MAP3K121.36822566
52ZAK1.35941208
53MAP3K31.33438212
54CSF1R1.32471272
55OXSR11.31802371
56MAP3K131.31075440
57IKBKE1.31007364
58IRAK11.30516306
59EPHA31.26561019
60NEK21.21872869
61HCK1.19556235
62ABL21.17189300
63NEK91.16879668
64TXK1.15654087
65BRSK21.13627907
66STK31.12886834
67LYN1.12510824
68IKBKB1.09416809
69TTK1.06839755
70ERBB41.05726804
71TAOK21.04428257
72TAOK31.01431087
73PDK11.00745952
74FGFR31.00153483
75NME20.99921012
76TGFBR20.99621245
77MAP3K60.98637757
78KDR0.97986655
79PIK3CG0.97764280
80TEC0.95261769
81PTK60.94199285
82ARAF0.94113005
83YES10.91403370
84MAPK110.89728315
85MAP3K50.88703528
86KIT0.86669100
87NLK0.86343359
88SIK30.81716290
89LCK0.81591080
90INSRR0.81309089
91PIK3CA0.78738942
92FLT30.75822029
93ITK0.75003441
94MET0.74164724
95KSR20.74120367
96MAP2K20.71628290
97LATS20.70311785
98MAP3K110.66741479
99TYK20.66730614
100MAP2K60.65085086
101CDC42BPA0.64577115
102MARK30.64111767
103EIF2AK30.63351488
104PRKCZ0.62263270
105PTK20.61769452
106MAP3K80.61602135
107PRKAA10.61323949
108STK240.61045648
109PRKAA20.61029033
110ERBB20.59735971
111PRKCI0.59589630
112GRK70.58658955
113CSNK1G10.58317142
114BRAF0.58044562
115FYN0.57439711
116LRRK20.57110070
117GSK3A0.55978473
118NUAK10.55304854
119MYLK0.54971894
120MAP3K70.54184440
121CAMK2G0.53985373
122MAP2K10.53478072
123PLK10.52389484
124BRSK10.51885226
125IRAK20.51803445
126TESK20.51407762
127CDK60.51012342
128CAMKK20.50639525
129MAP2K40.50207058
130PRKCQ0.50154247
131PDPK10.48337492
132MAPK70.48220763
133PLK30.45434038
134PAK40.45131897
135GRK60.44722384
136AURKB0.44550480
137BMX0.44033769
138CSNK1G30.43665315
139RET0.43651688
140FER0.43246474
141CDK40.43037503
142IGF1R0.42793308
143MTOR0.42041325
144MAPK40.42002502
145GRK10.41991920
146PIM20.41542603
147STK380.39831359
148PTK2B0.39365248
149PRKACG0.39187195
150DYRK1B0.39101327
151PRKCD0.39038241
152AURKA0.37854378
153MAP2K30.37821327
154PAK30.36391034
155JAK20.34452944
156DYRK30.33553029
157PIM10.33320233
158MAPK120.33135574
159TIE10.32827062
160STK100.32826292
161PRKCG0.31560735
162ABL10.30650197
163PNCK0.30118298
164CSNK1A1L0.29411283
165SGK30.28893973
166RIPK10.28678296
167DAPK20.27500746
168CSNK1E0.26292131
169TBK10.24978345

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.56075925
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.22590014
3Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.85339187
4Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.76050606
5Nitrogen metabolism_Homo sapiens_hsa009102.71958218
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.71374734
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.66756447
8Fatty acid degradation_Homo sapiens_hsa000712.57547978
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.56780417
10Arginine biosynthesis_Homo sapiens_hsa002202.46175154
11Tryptophan metabolism_Homo sapiens_hsa003802.43951371
12Pentose and glucuronate interconversions_Homo sapiens_hsa000402.42577539
13Butanoate metabolism_Homo sapiens_hsa006502.40403433
14Peroxisome_Homo sapiens_hsa041462.13430752
15Vitamin B6 metabolism_Homo sapiens_hsa007502.09527612
16Folate biosynthesis_Homo sapiens_hsa007902.09426094
17Propanoate metabolism_Homo sapiens_hsa006402.07189680
18Complement and coagulation cascades_Homo sapiens_hsa046101.97687466
19Fatty acid metabolism_Homo sapiens_hsa012121.94732003
20Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.93262565
21Drug metabolism - other enzymes_Homo sapiens_hsa009831.93125227
22PPAR signaling pathway_Homo sapiens_hsa033201.90354965
23Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.89504954
24beta-Alanine metabolism_Homo sapiens_hsa004101.89136910
252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.88119500
26* Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.79855531
27Vitamin digestion and absorption_Homo sapiens_hsa049771.79293192
28Chemical carcinogenesis_Homo sapiens_hsa052041.74207493
29Histidine metabolism_Homo sapiens_hsa003401.72650192
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.68896422
31Steroid hormone biosynthesis_Homo sapiens_hsa001401.65854023
32Retinol metabolism_Homo sapiens_hsa008301.61109429
33Selenocompound metabolism_Homo sapiens_hsa004501.56247497
34Cyanoamino acid metabolism_Homo sapiens_hsa004601.50379438
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.47802940
36Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.46943652
37Pyruvate metabolism_Homo sapiens_hsa006201.44440966
38Bile secretion_Homo sapiens_hsa049761.41457184
39Carbon metabolism_Homo sapiens_hsa012001.40026803
40Fatty acid elongation_Homo sapiens_hsa000621.38955158
41Caffeine metabolism_Homo sapiens_hsa002321.38671299
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.36117144
43Biosynthesis of amino acids_Homo sapiens_hsa012301.32398830
44Phenylalanine metabolism_Homo sapiens_hsa003601.31068479
45Fat digestion and absorption_Homo sapiens_hsa049751.29769443
46Sulfur metabolism_Homo sapiens_hsa009201.27370619
47Starch and sucrose metabolism_Homo sapiens_hsa005001.23712720
48Leishmaniasis_Homo sapiens_hsa051401.20970087
49Staphylococcus aureus infection_Homo sapiens_hsa051501.16396209
50Glutathione metabolism_Homo sapiens_hsa004801.16279893
51Arginine and proline metabolism_Homo sapiens_hsa003301.14602358
52Steroid biosynthesis_Homo sapiens_hsa001001.06000179
53Pentose phosphate pathway_Homo sapiens_hsa000301.05196478
54Tyrosine metabolism_Homo sapiens_hsa003501.04505476
55Pertussis_Homo sapiens_hsa051331.01302960
56Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.01286867
57Glycerolipid metabolism_Homo sapiens_hsa005610.99385537
58Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.94960871
59ABC transporters_Homo sapiens_hsa020100.94704261
60Osteoclast differentiation_Homo sapiens_hsa043800.92606922
61Sulfur relay system_Homo sapiens_hsa041220.91459201
62Allograft rejection_Homo sapiens_hsa053300.91454546
63Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.91098809
64Maturity onset diabetes of the young_Homo sapiens_hsa049500.89293504
65Graft-versus-host disease_Homo sapiens_hsa053320.88393314
66Fructose and mannose metabolism_Homo sapiens_hsa000510.84868224
67Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.79631877
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.78937554
69Tuberculosis_Homo sapiens_hsa051520.75970239
70Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.75835405
71Autoimmune thyroid disease_Homo sapiens_hsa053200.75549744
72Asthma_Homo sapiens_hsa053100.75494483
73Carbohydrate digestion and absorption_Homo sapiens_hsa049730.74814857
74Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.73827805
75One carbon pool by folate_Homo sapiens_hsa006700.72362690
76Toll-like receptor signaling pathway_Homo sapiens_hsa046200.69769638
77Lysine degradation_Homo sapiens_hsa003100.68798303
78Glycerophospholipid metabolism_Homo sapiens_hsa005640.66077034
79NOD-like receptor signaling pathway_Homo sapiens_hsa046210.65938858
80African trypanosomiasis_Homo sapiens_hsa051430.65362076
81Malaria_Homo sapiens_hsa051440.62334046
82Intestinal immune network for IgA production_Homo sapiens_hsa046720.61802874
83Metabolic pathways_Homo sapiens_hsa011000.61307569
84Regulation of autophagy_Homo sapiens_hsa041400.59507983
85Hematopoietic cell lineage_Homo sapiens_hsa046400.56418257
86Type I diabetes mellitus_Homo sapiens_hsa049400.55782847
87Legionellosis_Homo sapiens_hsa051340.55743018
88Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.55134998
89NF-kappa B signaling pathway_Homo sapiens_hsa040640.50432255
90Proteasome_Homo sapiens_hsa030500.50391932
91Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.50208739
92Galactose metabolism_Homo sapiens_hsa000520.48235319
93Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.46213231
94Fatty acid biosynthesis_Homo sapiens_hsa000610.46082996
95TNF signaling pathway_Homo sapiens_hsa046680.44868552
96Rheumatoid arthritis_Homo sapiens_hsa053230.44300708
97Influenza A_Homo sapiens_hsa051640.44000331
98Chemokine signaling pathway_Homo sapiens_hsa040620.43669365
99Renin-angiotensin system_Homo sapiens_hsa046140.42513328
100B cell receptor signaling pathway_Homo sapiens_hsa046620.41769345
101Toxoplasmosis_Homo sapiens_hsa051450.40002582
102Phagosome_Homo sapiens_hsa041450.39017343
103Hepatitis C_Homo sapiens_hsa051600.37867178
104Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.36500757
105Antigen processing and presentation_Homo sapiens_hsa046120.35835648
106alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.34310783
107Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.34043468
108Amoebiasis_Homo sapiens_hsa051460.33547175
109Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.32808392
110Platelet activation_Homo sapiens_hsa046110.32146197
111Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.31389267
112Jak-STAT signaling pathway_Homo sapiens_hsa046300.28108092
113Leukocyte transendothelial migration_Homo sapiens_hsa046700.27768365
114Sphingolipid metabolism_Homo sapiens_hsa006000.26381997
115RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.25579501
116Mineral absorption_Homo sapiens_hsa049780.25132320
117Linoleic acid metabolism_Homo sapiens_hsa005910.22458549
118Pyrimidine metabolism_Homo sapiens_hsa002400.20952100
119Arachidonic acid metabolism_Homo sapiens_hsa005900.18252206
120Adipocytokine signaling pathway_Homo sapiens_hsa049200.14931103
121Insulin resistance_Homo sapiens_hsa049310.06815532
122Protein digestion and absorption_Homo sapiens_hsa049740.05612787
123Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.05425133
124Lysosome_Homo sapiens_hsa041420.05121481
125AMPK signaling pathway_Homo sapiens_hsa041520.01907713
126Prion diseases_Homo sapiens_hsa050200.01783608
127Other glycan degradation_Homo sapiens_hsa00511-0.1937306
128Insulin signaling pathway_Homo sapiens_hsa04910-0.1884297
129Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1763428
130Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970-0.1564050
131Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1515463
132Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.1400569
133Circadian rhythm_Homo sapiens_hsa04710-0.1384226
134Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1377264
135Glucagon signaling pathway_Homo sapiens_hsa04922-0.0515549
136RNA polymerase_Homo sapiens_hsa03020-0.0325367
137Purine metabolism_Homo sapiens_hsa00230-0.0309939
138Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.0256020

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