VNN2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene product is a member of the Vanin family of proteins that share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. The encoded protein is a GPI-anchored cell surface molecule that plays a role in transendothelial migration of neutrophils. This gene lies in close proximity to, and in same transcriptional orientation as two other vanin genes on chromosome 6q23-q24. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.80901080
2positive regulation by organism of defense response of other organism involved in symbiotic interact6.80901080
3modulation by symbiont of host immune response (GO:0052553)6.80901080
4positive regulation by symbiont of host defense response (GO:0052509)6.80901080
5modulation by symbiont of host defense response (GO:0052031)6.80901080
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.80901080
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.53487360
8negative regulation of cell killing (GO:0031342)6.53487360
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.44089958
10detection of molecule of bacterial origin (GO:0032490)6.04556355
11positive regulation of gamma-delta T cell activation (GO:0046645)5.97608647
12macrophage activation involved in immune response (GO:0002281)5.53808453
13detection of other organism (GO:0098543)5.34841712
14positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)5.33980942
15detection of external biotic stimulus (GO:0098581)5.18723257
16neutrophil activation involved in immune response (GO:0002283)5.15907533
17regulation of B cell receptor signaling pathway (GO:0050855)5.15898756
18antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.14893298
19regulation of interferon-beta biosynthetic process (GO:0045357)5.04593434
20antigen processing and presentation of endogenous antigen (GO:0019883)5.00618278
21microglial cell activation (GO:0001774)4.89360238
22response to peptidoglycan (GO:0032494)4.82753400
23detection of bacterium (GO:0016045)4.77299419
24cellular extravasation (GO:0045123)4.74005802
25response to host immune response (GO:0052572)4.66374250
26response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.66374250
27antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.55598209
28leukocyte migration involved in inflammatory response (GO:0002523)4.53939473
29detection of biotic stimulus (GO:0009595)4.53202761
30leukocyte aggregation (GO:0070486)4.52923069
31negative regulation of interleukin-12 production (GO:0032695)4.51379888
32negative regulation of lymphocyte mediated immunity (GO:0002707)4.48644728
33macrophage activation (GO:0042116)4.39095793
34response to interleukin-15 (GO:0070672)4.35316508
35positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.34895842
36positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)4.33578193
37regulation of gamma-delta T cell activation (GO:0046643)4.32214211
38neutrophil activation (GO:0042119)4.30569579
39response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.27731752
40response to host (GO:0075136)4.27731752
41response to host defenses (GO:0052200)4.27731752
42respiratory burst (GO:0045730)4.25637896
43neutrophil mediated immunity (GO:0002446)4.16165041
44cellular response to interleukin-15 (GO:0071350)4.01584107
45production of molecular mediator involved in inflammatory response (GO:0002532)4.00043236
46regulation of gamma-delta T cell differentiation (GO:0045586)3.88211428
47negative regulation of leukocyte mediated immunity (GO:0002704)3.86813279
48myeloid cell activation involved in immune response (GO:0002275)3.86537245
49granulocyte activation (GO:0036230)3.86267599
50immunoglobulin mediated immune response (GO:0016064)3.79864324
51negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.78523681
52negative regulation of T cell mediated immunity (GO:0002710)3.73353482
53regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.68148099
54negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.62414587
55myeloid leukocyte mediated immunity (GO:0002444)3.61019483
56B cell receptor signaling pathway (GO:0050853)3.60811594
57antigen processing and presentation via MHC class Ib (GO:0002475)3.56644399
58regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.56088526
59positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.46158867
60regulation of mast cell degranulation (GO:0043304)3.44848363
61cellular response to type I interferon (GO:0071357)3.39162312
62type I interferon signaling pathway (GO:0060337)3.39162312
63positive regulation of interferon-alpha production (GO:0032727)3.38110443
64response to type I interferon (GO:0034340)3.36284224
65regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.31440364
66negative regulation of T-helper cell differentiation (GO:0045623)3.29150629
67negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.29150629
68positive regulation of mast cell activation (GO:0033005)3.27466809
69regulation of myeloid leukocyte mediated immunity (GO:0002886)3.24437977
70dendritic cell migration (GO:0036336)3.23610931
71defense response to protozoan (GO:0042832)3.22540303
72regulation of mast cell activation involved in immune response (GO:0033006)3.18593389
73germinal center formation (GO:0002467)3.15714706
74regulation of B cell differentiation (GO:0045577)3.14967121
75regulation of interferon-alpha production (GO:0032647)3.14786903
76leukocyte degranulation (GO:0043299)3.14226272
77regulation of mast cell activation (GO:0033003)3.13185370
78dendritic cell chemotaxis (GO:0002407)3.12128650
79negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.11248099
80regulation of tolerance induction (GO:0002643)3.09930364
81lipopolysaccharide-mediated signaling pathway (GO:0031663)3.06936700
82regulation of T-helper 2 cell differentiation (GO:0045628)3.06856207
83B cell mediated immunity (GO:0019724)3.05442224
84negative regulation of immunoglobulin mediated immune response (GO:0002890)3.05233431
85negative regulation of B cell mediated immunity (GO:0002713)3.05233431
86regulation of leukocyte degranulation (GO:0043300)3.03223544
87regulation of T cell mediated cytotoxicity (GO:0001914)3.02333787
88negative thymic T cell selection (GO:0045060)3.02109711
89myeloid leukocyte activation (GO:0002274)3.01220092
90interferon-gamma-mediated signaling pathway (GO:0060333)2.99812797
91negative T cell selection (GO:0043383)2.99524446
92positive regulation of T cell mediated cytotoxicity (GO:0001916)2.99448544
93negative regulation of type 2 immune response (GO:0002829)2.98688783
94response to muramyl dipeptide (GO:0032495)2.98016810
95neutrophil chemotaxis (GO:0030593)2.96400358
96positive regulation of toll-like receptor signaling pathway (GO:0034123)2.95889489
97positive regulation of cellular amide metabolic process (GO:0034250)2.93963471
98regulation of T cell tolerance induction (GO:0002664)2.93187998
99positive regulation of B cell differentiation (GO:0045579)2.91633622
100T-helper 1 type immune response (GO:0042088)2.89480538

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.69202146
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.66265008
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.64917350
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.35985963
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.17066339
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.91560612
7IRF8_27001747_Chip-Seq_BMDM_Mouse3.45148326
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.44300655
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.10565466
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.09615579
11MYB_21317192_ChIP-Seq_ERMYB_Mouse3.03528797
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.98620726
13RUNX_20019798_ChIP-Seq_JUKART_Human2.95413028
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.94973906
15* SPI1_23547873_ChIP-Seq_NB4_Human2.89473825
16* SPI1_23127762_ChIP-Seq_K562_Human2.60829942
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.48932014
18VDR_24763502_ChIP-Seq_THP-1_Human2.45731424
19MYB_26560356_Chip-Seq_TH2_Human2.43496073
20SMAD_19615063_ChIP-ChIP_OVARY_Human2.39379542
21FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.35898801
22RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.32178024
23MAF_26560356_Chip-Seq_TH1_Human2.23182460
24VDR_21846776_ChIP-Seq_THP-1_Human2.22606897
25Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.19652998
26STAT4_19710469_ChIP-ChIP_TH1__Mouse2.19403228
27SCL_19346495_ChIP-Seq_HPC-7_Human2.19243273
28BRD4_27068464_Chip-Seq_AML-cells_Mouse2.19020360
29RUNX1_22412390_ChIP-Seq_EML_Mouse2.15684303
30E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.08788866
31MYB_26560356_Chip-Seq_TH1_Human2.06565465
32NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.96429705
33UTX_26944678_Chip-Seq_JUKART_Human1.96071277
34CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.93611860
35VDR_24787735_ChIP-Seq_THP-1_Human1.91516162
36EGR1_19374776_ChIP-ChIP_THP-1_Human1.88925362
37VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.86395281
38GATA3_27048872_Chip-Seq_THYMUS_Human1.82098495
39MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.73875996
40NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.71941711
41TCF7_22412390_ChIP-Seq_EML_Mouse1.69328230
42RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.67579722
43MYC_22102868_ChIP-Seq_BL_Human1.62740619
44CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.58609163
45LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.56646200
46KDM2B_26808549_Chip-Seq_SUP-B15_Human1.56017408
47STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.55157000
48MAF_26560356_Chip-Seq_TH2_Human1.54741393
49GATA1_19941827_ChIP-Seq_MEL_Mouse1.51862899
50GATA3_26560356_Chip-Seq_TH2_Human1.49999557
51PU_27001747_Chip-Seq_BMDM_Mouse1.49526926
52BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.47433864
53TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.43509515
54PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.43247787
55GATA2_22383799_ChIP-Seq_G1ME_Mouse1.39614118
56LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.38440601
57KDM2B_26808549_Chip-Seq_DND41_Human1.37732655
58PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.35399862
59FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.34653677
60SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.29122674
61PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.28594093
62CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.28147813
63GATA1_22025678_ChIP-Seq_K562_Human1.26470490
64KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.26437095
65GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.23057103
66CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.22877148
67SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.22363465
68KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.21835967
69ELF1_17652178_ChIP-ChIP_JURKAT_Human1.20797142
70CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19384860
71GATA2_21666600_ChIP-Seq_HMVEC_Human1.19111084
72ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.15666634
73GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.14402300
74GATA1_22383799_ChIP-Seq_G1ME_Mouse1.13610485
75SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.13388456
76SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12210203
77* RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.09497407
78STAT6_21828071_ChIP-Seq_BEAS2B_Human1.05694264
79THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.05474483
80PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04813136
81VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.04256203
82GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03406811
83SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.01419048
84GATA1_19941826_ChIP-Seq_K562_Human0.97413120
85KDM2B_26808549_Chip-Seq_JURKAT_Human0.96716960
86PU.1_20513432_ChIP-Seq_Bcells_Mouse0.95760636
87STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.94957023
88GATA2_19941826_ChIP-Seq_K562_Human0.91972201
89NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.91939315
90IKZF1_21737484_ChIP-ChIP_HCT116_Human0.88804125
91ELK3_25401928_ChIP-Seq_HUVEC_Human0.85605848
92GATA1_19941827_ChIP-Seq_MEL86_Mouse0.83101306
93RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82699395
94SMRT_27268052_Chip-Seq_Bcells_Human0.80944270
95BCL6_27268052_Chip-Seq_Bcells_Human0.75296987
96SPI1_20517297_ChIP-Seq_HL60_Human0.70950997
97NCOR1_26117541_ChIP-Seq_K562_Human0.70852721
98BCOR_27268052_Chip-Seq_Bcells_Human0.65302192
99KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.64830839
100RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.64604168

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to6.00316953
2MP0003436_decreased_susceptibility_to4.12666406
3MP0001835_abnormal_antigen_presentation3.81011549
4MP0003303_peritoneal_inflammation3.68710625
5MP0002419_abnormal_innate_immunity3.15989311
6MP0009785_altered_susceptibility_to2.99820534
7MP0001800_abnormal_humoral_immune2.92662855
8MP0005671_abnormal_response_to2.90103520
9MP0005025_abnormal_response_to2.87187117
10MP0000685_abnormal_immune_system2.78729096
11MP0005000_abnormal_immune_tolerance2.78113728
12MP0001790_abnormal_immune_system2.61046465
13MP0005387_immune_system_phenotype2.61046465
14MP0002723_abnormal_immune_serum2.59534035
15MP0002420_abnormal_adaptive_immunity2.50346630
16MP0002452_abnormal_antigen_presenting2.48517977
17MP0008260_abnormal_autophagy2.47720720
18MP0001819_abnormal_immune_cell2.47625476
19MP0006082_CNS_inflammation2.47453649
20MP0003191_abnormal_cellular_cholesterol2.40015816
21MP0003300_gastrointestinal_ulcer2.31048846
22MP0002148_abnormal_hypersensitivity_rea2.20509186
23MP0002132_abnormal_respiratory_system2.20282137
24MP0001533_abnormal_skeleton_physiology2.17489836
25MP0003763_abnormal_thymus_physiology2.02426713
26MP0002405_respiratory_system_inflammati1.97733377
27MP0003828_pulmonary_edema1.94322127
28MP0002277_abnormal_respiratory_mucosa1.92381322
29MP0005464_abnormal_platelet_physiology1.89512867
30MP0002398_abnormal_bone_marrow1.87803122
31MP0000716_abnormal_immune_system1.86479152
32MP0005451_abnormal_body_composition1.79763675
33MP0001845_abnormal_inflammatory_respons1.76801441
34MP0003172_abnormal_lysosome_physiology1.75342011
35MP0004883_abnormal_blood_vessel1.73884273
36MP0004381_abnormal_hair_follicle1.70527909
37MP0009278_abnormal_bone_marrow1.66308798
38MP0010155_abnormal_intestine_physiology1.64752933
39MP0009764_decreased_sensitivity_to1.64254437
40MP0000465_gastrointestinal_hemorrhage1.63730538
41MP0003866_abnormal_defecation1.62106174
42MP0002722_abnormal_immune_system1.56278440
43MP0000689_abnormal_spleen_morphology1.55422495
44MP0002396_abnormal_hematopoietic_system1.54330295
45MP0004947_skin_inflammation1.53539134
46MP0000569_abnormal_digit_pigmentation1.48014938
47MP0003183_abnormal_peptide_metabolism1.46608508
48MP0002429_abnormal_blood_cell1.44797212
49MP0000858_altered_metastatic_potential1.43345775
50MP0008469_abnormal_protein_level1.41515417
51MP0000703_abnormal_thymus_morphology1.39989831
52MP0005164_abnormal_response_to1.37159511
53MP0009333_abnormal_splenocyte_physiolog1.34572286
54MP0003075_altered_response_to1.33693110
55MP0005310_abnormal_salivary_gland1.29387242
56MP0001545_abnormal_hematopoietic_system1.28480729
57MP0005397_hematopoietic_system_phenotyp1.28480729
58MP0002166_altered_tumor_susceptibility1.26997419
59MP0003690_abnormal_glial_cell1.19979018
60MP0001851_eye_inflammation1.17720814
61MP0002998_abnormal_bone_remodeling1.10104521
62MP0005166_decreased_susceptibility_to1.02645315
63MP0005075_abnormal_melanosome_morpholog0.97152541
64MP0003448_altered_tumor_morphology0.94872774
65MP0003221_abnormal_cardiomyocyte_apopto0.93572441
66MP0000015_abnormal_ear_pigmentation0.91366690
67MP0004510_myositis0.90265234
68MP0003656_abnormal_erythrocyte_physiolo0.87602104
69MP0008004_abnormal_stomach_pH0.86738451
70MP0003045_fibrosis0.86185559
71MP0003787_abnormal_imprinting0.84557949
72MP0000343_altered_response_to0.83504286
73MP0009763_increased_sensitivity_to0.82770890
74MP0005390_skeleton_phenotype0.81473723
75MP0000604_amyloidosis0.80933928
76MP0002006_tumorigenesis0.79752551
77MP0004130_abnormal_muscle_cell0.77038739
78MP0001663_abnormal_digestive_system0.75704559
79MP0001853_heart_inflammation0.72992413
80MP0004484_altered_response_of0.71051765
81MP0004808_abnormal_hematopoietic_stem0.69202021
82MP0008874_decreased_physiological_sensi0.68069085
83MP0002332_abnormal_exercise_endurance0.67571050
84MP0005058_abnormal_lysosome_morphology0.65148656
85MP0009765_abnormal_xenobiotic_induced0.64370984
86MP0000249_abnormal_blood_vessel0.63298575
87MP0002928_abnormal_bile_duct0.62346256
88MP0002138_abnormal_hepatobiliary_system0.59851685
89MP0003795_abnormal_bone_structure0.59256163
90MP0005388_respiratory_system_phenotype0.57635690
91MP0002133_abnormal_respiratory_system0.57635690
92MP0005376_homeostasis/metabolism_phenot0.57297803
93MP0003806_abnormal_nucleotide_metabolis0.57002059
94MP0003252_abnormal_bile_duct0.56811353
95MP0005174_abnormal_tail_pigmentation0.53976319
96MP0001986_abnormal_taste_sensitivity0.50691144
97MP0005319_abnormal_enzyme/_coenzyme0.50644029
98MP0000490_abnormal_crypts_of0.49802998
99MP0001958_emphysema0.49189779
100MP0003091_abnormal_cell_migration0.48226287

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.94837855
2Recurrent bacterial skin infections (HP:0005406)6.38468527
3Recurrent abscess formation (HP:0002722)6.37345328
4Myositis (HP:0100614)6.29986198
5Orchitis (HP:0100796)6.22498766
6Optic neuritis (HP:0100653)5.99518512
7Retrobulbar optic neuritis (HP:0100654)5.99518512
8Abnormality of macrophages (HP:0004311)5.27825002
9Recurrent gram-negative bacterial infections (HP:0005420)5.25816979
10Stomatitis (HP:0010280)5.00389922
11Gastrointestinal infarctions (HP:0005244)4.77452626
12Elevated erythrocyte sedimentation rate (HP:0003565)4.65133863
13Keratoconjunctivitis sicca (HP:0001097)4.46017754
14Recurrent fungal infections (HP:0002841)4.34543472
15Mediastinal lymphadenopathy (HP:0100721)4.26946995
16Recurrent skin infections (HP:0001581)4.16766571
17Keratoconjunctivitis (HP:0001096)4.14199620
18Chronic obstructive pulmonary disease (HP:0006510)4.13937911
19Obstructive lung disease (HP:0006536)4.13937911
20Meningitis (HP:0001287)4.09652990
21Encephalitis (HP:0002383)3.98006222
22Abnormal delayed hypersensitivity skin test (HP:0002963)3.92985490
23Gingivitis (HP:0000230)3.91226160
24Spontaneous hematomas (HP:0007420)3.77164116
25Chronic mucocutaneous candidiasis (HP:0002728)3.70662045
26Recurrent cutaneous fungal infections (HP:0011370)3.70662045
27T lymphocytopenia (HP:0005403)3.64957362
28Hypochromic microcytic anemia (HP:0004840)3.62017011
29Peritonitis (HP:0002586)3.61746663
30Urticaria (HP:0001025)3.56684738
31Vasculitis (HP:0002633)3.55537447
32Abnormality of T cell number (HP:0011839)3.51833838
33Chest pain (HP:0100749)3.35654370
34Arterial thrombosis (HP:0004420)3.33509966
35Hemoptysis (HP:0002105)3.28795845
36Gingival bleeding (HP:0000225)3.24358245
37Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.22932960
38Cellulitis (HP:0100658)3.21699227
39Increased IgE level (HP:0003212)3.19260332
40Hypochromic anemia (HP:0001931)3.11772770
41Episodic fever (HP:0001954)3.11029808
42Pulmonary infiltrates (HP:0002113)3.08395694
43Prolonged bleeding time (HP:0003010)3.06854117
44Anorexia (HP:0002039)3.04807543
45Pulmonary embolism (HP:0002204)2.93741226
46Leukocytosis (HP:0001974)2.93522644
47Abnormality of T cells (HP:0002843)2.81839483
48Gangrene (HP:0100758)2.69077781
49Epistaxis (HP:0000421)2.67769968
50Amyloidosis (HP:0011034)2.65012928
51Recurrent viral infections (HP:0004429)2.62733719
52Abnormality of the peritoneum (HP:0002585)2.60676940
53Inflammation of the large intestine (HP:0002037)2.57637261
54Osteomyelitis (HP:0002754)2.56470209
55Increased IgM level (HP:0003496)2.53122963
56Abnormality of the pleura (HP:0002103)2.52342270
57Gastrointestinal inflammation (HP:0004386)2.44915819
58Sepsis (HP:0100806)2.43612370
59Granulocytopenia (HP:0001913)2.41730998
60Microcytic anemia (HP:0001935)2.38348204
61Abnormality of the endocardium (HP:0004306)2.37408384
62Subacute progressive viral hepatitis (HP:0006572)2.36004415
63Keratitis (HP:0000491)2.26379187
64Pustule (HP:0200039)2.25394471
65Acute hepatic failure (HP:0006554)2.23692398
66Panhypogammaglobulinemia (HP:0003139)2.22646442
67Glomerulopathy (HP:0100820)2.21448467
68Abnormality of T cell physiology (HP:0011840)2.19631061
69Eosinophilia (HP:0001880)2.17825435
70Lymphopenia (HP:0001888)2.16031902
71Vertigo (HP:0002321)2.14091664
72Viral hepatitis (HP:0006562)2.13526969
73Slow saccadic eye movements (HP:0000514)2.09046328
74Acne (HP:0001061)2.07615102
75Abnormality of cells of the lymphoid lineage (HP:0012140)2.06970615
76Hypergammaglobulinemia (HP:0010702)2.03581125
77Skin ulcer (HP:0200042)2.03377895
78Petechiae (HP:0000967)2.01816578
79Recurrent bronchitis (HP:0002837)2.00588658
80Colitis (HP:0002583)1.96737237
81Recurrent pneumonia (HP:0006532)1.96709967
82Abnormality of the pericardium (HP:0001697)1.96563174
83Chronic otitis media (HP:0000389)1.93912558
84Cheilitis (HP:0100825)1.93411625
85Thrombophlebitis (HP:0004418)1.92271006
86Polyneuropathy (HP:0001271)1.89993781
87Difficulty running (HP:0009046)1.87607487
88Premature loss of primary teeth (HP:0006323)1.87182015
89IgM deficiency (HP:0002850)1.86857033
90Abnormal platelet volume (HP:0011876)1.86329415
91Abnormality of eosinophils (HP:0001879)1.85797083
92Metaphyseal cupping (HP:0003021)1.85573067
93Skin rash (HP:0000988)1.81987900
94Autoimmune hemolytic anemia (HP:0001890)1.76481829
95Polycythemia (HP:0001901)1.76328769
96Amaurosis fugax (HP:0100576)1.75412261
97Toxemia of pregnancy (HP:0100603)1.70390293
98Segmental peripheral demyelination/remyelination (HP:0003481)1.70127296
99Hepatosplenomegaly (HP:0001433)1.69629659
100Hypermelanotic macule (HP:0001034)1.67845957

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.97192318
2IRAK43.61568986
3BLK3.41476625
4MAP2K33.23660867
5MAP4K13.09672937
6CSK2.93719515
7TYK22.80505530
8FES2.55036480
9ERN12.50777317
10GRK62.35133590
11EPHB12.25217565
12ZAP702.03474996
13TNK21.96977479
14FGR1.92849296
15TXK1.92526866
16BTK1.87112692
17JAK31.86134804
18HCK1.77205081
19MAP3K31.70444564
20SYK1.68191185
21TAOK11.65923512
22IKBKE1.61088620
23PRPF4B1.60306466
24JAK21.59818014
25KSR21.58235599
26MAP3K141.57325250
27YES11.52847385
28LYN1.44461071
29IRAK11.43819210
30MAP3K111.40292623
31MAP3K21.39820145
32JAK11.39226949
33MAP3K11.38164673
34TAOK31.34132251
35MAP3K61.27438187
36IRAK21.27247129
37TBK11.14022468
38BMPR21.13262869
39LCK1.11692276
40ITK1.11292196
41CSF1R1.06683198
42MAP3K131.05664444
43MATK1.04316502
44TEC1.03723969
45SIK31.03481591
46LRRK21.02544027
47MARK20.93075755
48KIT0.92888750
49MARK30.92884942
50FGFR30.91639197
51MAP2K40.91136020
52PIK3CG0.90699902
53PTK60.89821118
54PDK10.82541121
55STK100.79819688
56CDK190.79815528
57PTK2B0.78575152
58RAF10.77594332
59MAP3K50.76248229
60TGFBR20.75540018
61KSR10.71075875
62PDPK10.68813536
63FYN0.68334409
64IKBKB0.68078340
65PRKD20.68075890
66EPHA30.66842347
67STK110.66342520
68DYRK1B0.66336418
69SGK30.62336716
70MAP2K60.61916147
71NLK0.60961246
72TAOK20.60044648
73FGFR40.58370390
74SIK20.55344579
75TESK20.55074096
76MAP3K70.54453713
77RET0.53998020
78WNK10.53344644
79DYRK30.52651351
80SGK20.52278674
81PRKCQ0.50689803
82TRIB30.50237552
83STK380.48769649
84CAMKK20.46892994
85MAPK120.44771895
86PIM10.42788577
87HIPK20.42233127
88DAPK20.41930394
89SMG10.39219808
90MAPKAPK20.38986163
91MAPK70.37063140
92CDC42BPA0.34997364
93PRKCZ0.34181865
94RPS6KC10.33982492
95RPS6KL10.33982492
96CAMKK10.33728167
97GRK70.32522555
98RPS6KA60.29823098
99PRKG20.29309235
100ACVR1B0.26995070

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.23923120
2Osteoclast differentiation_Homo sapiens_hsa043803.07475120
3Staphylococcus aureus infection_Homo sapiens_hsa051502.85447227
4Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.46911338
5B cell receptor signaling pathway_Homo sapiens_hsa046622.34661593
6Tuberculosis_Homo sapiens_hsa051522.31373005
7Toll-like receptor signaling pathway_Homo sapiens_hsa046202.24154092
8Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.21770778
9NOD-like receptor signaling pathway_Homo sapiens_hsa046212.13103659
10Graft-versus-host disease_Homo sapiens_hsa053322.11145232
11Allograft rejection_Homo sapiens_hsa053302.01170544
12Malaria_Homo sapiens_hsa051441.99645043
13Measles_Homo sapiens_hsa051621.93222078
14Primary immunodeficiency_Homo sapiens_hsa053401.91946687
15Autoimmune thyroid disease_Homo sapiens_hsa053201.87861359
16Legionellosis_Homo sapiens_hsa051341.84205480
17Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.81299576
18Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.79424926
19Chemokine signaling pathway_Homo sapiens_hsa040621.74166159
20T cell receptor signaling pathway_Homo sapiens_hsa046601.67675401
21NF-kappa B signaling pathway_Homo sapiens_hsa040641.64466971
22Acute myeloid leukemia_Homo sapiens_hsa052211.64011335
23Hematopoietic cell lineage_Homo sapiens_hsa046401.60077225
24Toxoplasmosis_Homo sapiens_hsa051451.53960452
25Influenza A_Homo sapiens_hsa051641.53174313
26Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.47965426
27Type I diabetes mellitus_Homo sapiens_hsa049401.46947611
28Antigen processing and presentation_Homo sapiens_hsa046121.46548171
29Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.45032522
30Phagosome_Homo sapiens_hsa041451.44788154
31RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.43646816
32Jak-STAT signaling pathway_Homo sapiens_hsa046301.42517442
33Non-small cell lung cancer_Homo sapiens_hsa052231.37865347
34TNF signaling pathway_Homo sapiens_hsa046681.31600764
35Leukocyte transendothelial migration_Homo sapiens_hsa046701.29559180
36Herpes simplex infection_Homo sapiens_hsa051681.28064055
37Viral myocarditis_Homo sapiens_hsa054161.27964763
38Hepatitis B_Homo sapiens_hsa051611.24797466
39African trypanosomiasis_Homo sapiens_hsa051431.24343490
40Platelet activation_Homo sapiens_hsa046111.15814582
41Hepatitis C_Homo sapiens_hsa051601.14759867
42Salmonella infection_Homo sapiens_hsa051321.05355352
43Pancreatic cancer_Homo sapiens_hsa052121.05269639
44Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.04579636
45Pertussis_Homo sapiens_hsa051331.03818347
46Shigellosis_Homo sapiens_hsa051310.99097539
47Apoptosis_Homo sapiens_hsa042100.98730726
48VEGF signaling pathway_Homo sapiens_hsa043700.97752016
49Chronic myeloid leukemia_Homo sapiens_hsa052200.96676326
50Prolactin signaling pathway_Homo sapiens_hsa049170.95344261
51Intestinal immune network for IgA production_Homo sapiens_hsa046720.94782502
52Renal cell carcinoma_Homo sapiens_hsa052110.90965475
53Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.89677630
54Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.89314682
55Neurotrophin signaling pathway_Homo sapiens_hsa047220.86086662
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.85650132
57FoxO signaling pathway_Homo sapiens_hsa040680.83207153
58Dorso-ventral axis formation_Homo sapiens_hsa043200.81461639
59Rheumatoid arthritis_Homo sapiens_hsa053230.79496884
60Carbohydrate digestion and absorption_Homo sapiens_hsa049730.77047952
61Asthma_Homo sapiens_hsa053100.76986776
62Sphingolipid signaling pathway_Homo sapiens_hsa040710.76848179
63Endocytosis_Homo sapiens_hsa041440.76265377
64AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.75452323
65Endometrial cancer_Homo sapiens_hsa052130.74311859
66Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.73151009
67SNARE interactions in vesicular transport_Homo sapiens_hsa041300.72515458
68Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.71783923
69Phospholipase D signaling pathway_Homo sapiens_hsa040720.67081315
70Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.66970767
71Adipocytokine signaling pathway_Homo sapiens_hsa049200.66412657
72Phosphatidylinositol signaling system_Homo sapiens_hsa040700.64528677
73Notch signaling pathway_Homo sapiens_hsa043300.63769818
74Amoebiasis_Homo sapiens_hsa051460.63425138
75Viral carcinogenesis_Homo sapiens_hsa052030.62965818
76Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.62138041
77GnRH signaling pathway_Homo sapiens_hsa049120.61804009
78Choline metabolism in cancer_Homo sapiens_hsa052310.60415438
79HIF-1 signaling pathway_Homo sapiens_hsa040660.59729533
80Other glycan degradation_Homo sapiens_hsa005110.59152552
81Inositol phosphate metabolism_Homo sapiens_hsa005620.57924046
82Epstein-Barr virus infection_Homo sapiens_hsa051690.57621640
83mTOR signaling pathway_Homo sapiens_hsa041500.55781455
84Regulation of autophagy_Homo sapiens_hsa041400.53970567
85Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.53934445
86Insulin resistance_Homo sapiens_hsa049310.52771231
87Colorectal cancer_Homo sapiens_hsa052100.50853884
88Lysosome_Homo sapiens_hsa041420.49631567
89ErbB signaling pathway_Homo sapiens_hsa040120.49502424
90Type II diabetes mellitus_Homo sapiens_hsa049300.48974962
91MAPK signaling pathway_Homo sapiens_hsa040100.48008389
92Rap1 signaling pathway_Homo sapiens_hsa040150.44588600
93Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.43455232
94Prostate cancer_Homo sapiens_hsa052150.42858595
95Glioma_Homo sapiens_hsa052140.42452451
96HTLV-I infection_Homo sapiens_hsa051660.40718231
97Transcriptional misregulation in cancer_Homo sapiens_hsa052020.38910945
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.38523258
99Estrogen signaling pathway_Homo sapiens_hsa049150.37413928
100Regulation of actin cytoskeleton_Homo sapiens_hsa048100.36370322

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