VNN3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is the central gene in a cluster of three vanin genes on chromosome 6q23-q24. Extensive alternative splicing has been described; the two most common variants are represented as RefSeqs. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.35243664
2L-phenylalanine catabolic process (GO:0006559)7.35243664
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.03405336
4L-phenylalanine metabolic process (GO:0006558)7.03405336
5aromatic amino acid family catabolic process (GO:0009074)6.51159664
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.46513691
7tryptophan catabolic process (GO:0006569)5.74041256
8indole-containing compound catabolic process (GO:0042436)5.74041256
9indolalkylamine catabolic process (GO:0046218)5.74041256
10high-density lipoprotein particle remodeling (GO:0034375)5.69075033
11bile acid biosynthetic process (GO:0006699)5.63814283
12kynurenine metabolic process (GO:0070189)5.62579010
13alpha-linolenic acid metabolic process (GO:0036109)5.62492251
14glyoxylate metabolic process (GO:0046487)5.62481197
15negative regulation of fibrinolysis (GO:0051918)5.62016306
16urea cycle (GO:0000050)5.57391046
17urea metabolic process (GO:0019627)5.57391046
18detection of molecule of bacterial origin (GO:0032490)5.55608180
19positive regulation by symbiont of host defense response (GO:0052509)5.49438143
20modulation by symbiont of host defense response (GO:0052031)5.49438143
21modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.49438143
22modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.49438143
23positive regulation by organism of defense response of other organism involved in symbiotic interact5.49438143
24modulation by symbiont of host immune response (GO:0052553)5.49438143
25tryptophan metabolic process (GO:0006568)5.44319761
26regulation of fibrinolysis (GO:0051917)5.39016697
27sulfur amino acid catabolic process (GO:0000098)5.34371953
28protein carboxylation (GO:0018214)5.32950050
29peptidyl-glutamic acid carboxylation (GO:0017187)5.32950050
30complement activation, alternative pathway (GO:0006957)5.28659139
31cysteine metabolic process (GO:0006534)5.15961376
32regulation of B cell receptor signaling pathway (GO:0050855)5.14611105
33regulation of protein activation cascade (GO:2000257)5.12987160
34nitrogen cycle metabolic process (GO:0071941)5.11942385
35regulation of cholesterol esterification (GO:0010872)5.09893125
36reverse cholesterol transport (GO:0043691)5.01945344
37positive regulation of gamma-delta T cell activation (GO:0046645)4.99076602
38regulation of triglyceride catabolic process (GO:0010896)4.98707538
39plasma lipoprotein particle remodeling (GO:0034369)4.93477294
40protein-lipid complex remodeling (GO:0034368)4.93477294
41macromolecular complex remodeling (GO:0034367)4.93477294
42serine family amino acid catabolic process (GO:0009071)4.90980250
43positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.88614790
44bile acid metabolic process (GO:0008206)4.88463747
45antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.78501854
46tyrosine metabolic process (GO:0006570)4.77878847
47regulation of complement activation (GO:0030449)4.76786498
48negative regulation of cell killing (GO:0031342)4.76655746
49negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.76655746
50aromatic amino acid family metabolic process (GO:0009072)4.73218661
51fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.71482445
52phospholipid efflux (GO:0033700)4.70958527
53microglial cell activation (GO:0001774)4.70675736
54plasma lipoprotein particle clearance (GO:0034381)4.69301708
55homocysteine metabolic process (GO:0050667)4.67106516
56macrophage activation involved in immune response (GO:0002281)4.66758302
57triglyceride homeostasis (GO:0070328)4.60284350
58acylglycerol homeostasis (GO:0055090)4.60284350
59amino-acid betaine metabolic process (GO:0006577)4.59279750
60cellular extravasation (GO:0045123)4.53147737
61negative regulation of sterol transport (GO:0032372)4.49334671
62negative regulation of cholesterol transport (GO:0032375)4.49334671
63alpha-amino acid catabolic process (GO:1901606)4.45098743
64neutrophil activation involved in immune response (GO:0002283)4.43480579
65neutrophil mediated immunity (GO:0002446)4.35434432
66cellular ketone body metabolic process (GO:0046950)4.34419026
67cholesterol efflux (GO:0033344)4.31781310
68detection of external biotic stimulus (GO:0098581)4.28357615
69lysine metabolic process (GO:0006553)4.26641626
70lysine catabolic process (GO:0006554)4.26641626
71regulation of interferon-beta biosynthetic process (GO:0045357)4.24479821
72bile acid and bile salt transport (GO:0015721)4.15479200
73plasma lipoprotein particle assembly (GO:0034377)4.15222370
74macrophage activation (GO:0042116)4.11335564
75detection of other organism (GO:0098543)4.10590088
76cellular amino acid catabolic process (GO:0009063)4.09865648
77glycine metabolic process (GO:0006544)4.09658272
78low-density lipoprotein particle remodeling (GO:0034374)4.09323594
79imidazole-containing compound metabolic process (GO:0052803)4.08556196
80indolalkylamine metabolic process (GO:0006586)4.06959907
81coenzyme catabolic process (GO:0009109)4.05907024
82aldehyde catabolic process (GO:0046185)4.03377812
83fibrinolysis (GO:0042730)4.02528530
84neutrophil activation (GO:0042119)4.01517218
85glutamate metabolic process (GO:0006536)4.01223303
86regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.00269361
87negative regulation of lymphocyte mediated immunity (GO:0002707)3.99591658
88positive regulation of lipid catabolic process (GO:0050996)3.99526667
89cellular biogenic amine catabolic process (GO:0042402)3.99296005
90amine catabolic process (GO:0009310)3.99296005
91drug catabolic process (GO:0042737)3.99197314
92positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.98356285
93arginine metabolic process (GO:0006525)3.97419111
94benzene-containing compound metabolic process (GO:0042537)3.96223757
95negative regulation of lipase activity (GO:0060192)3.94223399
96cellular glucuronidation (GO:0052695)3.94214197
97cellular modified amino acid catabolic process (GO:0042219)3.90314024
98serine family amino acid metabolic process (GO:0009069)3.89241059
99ethanol oxidation (GO:0006069)3.89098568
100response to host immune response (GO:0052572)3.88295610
101response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.88295610
102blood coagulation, intrinsic pathway (GO:0007597)3.87359782
103positive regulation of triglyceride lipase activity (GO:0061365)3.87052188
104positive regulation of lipoprotein lipase activity (GO:0051006)3.87052188
105response to peptidoglycan (GO:0032494)3.85124848
106regulation of gamma-delta T cell activation (GO:0046643)3.84428661
107negative regulation of B cell mediated immunity (GO:0002713)3.82789520
108negative regulation of immunoglobulin mediated immune response (GO:0002890)3.82789520
109phospholipid homeostasis (GO:0055091)3.81625534
110dicarboxylic acid biosynthetic process (GO:0043650)3.81264557
111plasma lipoprotein particle organization (GO:0071827)3.78360812
112negative regulation of interleukin-12 production (GO:0032695)3.76877726
113positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.76779684
114cholesterol homeostasis (GO:0042632)3.76612359
115ketone body metabolic process (GO:1902224)3.75102352
116detection of biotic stimulus (GO:0009595)3.74439810
117cofactor catabolic process (GO:0051187)3.71958576
118protein-lipid complex assembly (GO:0065005)3.71728033
119acute-phase response (GO:0006953)3.70756858
120sterol homeostasis (GO:0055092)3.70432817
121very-low-density lipoprotein particle assembly (GO:0034379)3.70215089
122protein activation cascade (GO:0072376)3.69011584
123serine family amino acid biosynthetic process (GO:0009070)3.68054240
124myeloid leukocyte mediated immunity (GO:0002444)3.65384535
125complement activation (GO:0006956)3.65355371
126carboxylic acid catabolic process (GO:0046395)3.65114415
127organic acid catabolic process (GO:0016054)3.65114415
128cilium or flagellum-dependent cell motility (GO:0001539)3.64672632
129positive regulation of fatty acid beta-oxidation (GO:0032000)3.64436453
130leukocyte migration involved in inflammatory response (GO:0002523)3.61140512
131antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.60007224
132epoxygenase P450 pathway (GO:0019373)3.58957823
133opsonization (GO:0008228)3.58272856
134complement activation, classical pathway (GO:0006958)3.56764527
135protein-lipid complex subunit organization (GO:0071825)3.55484200
136short-chain fatty acid metabolic process (GO:0046459)3.55232152
137acetyl-CoA metabolic process (GO:0006084)3.53506502
138glucuronate metabolic process (GO:0019585)3.52904814
139uronic acid metabolic process (GO:0006063)3.52904814
140antigen processing and presentation of endogenous antigen (GO:0019883)3.51523627
141positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.49812142
142granulocyte activation (GO:0036230)3.49805515
143response to interleukin-15 (GO:0070672)3.48029729
144production of molecular mediator involved in inflammatory response (GO:0002532)3.47439251
145detection of bacterium (GO:0016045)3.46004561
146response to host (GO:0075136)3.40860382
147response to host defenses (GO:0052200)3.40860382
148response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.40860382
149cellular response to interleukin-15 (GO:0071350)3.40051921
150regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.38324318
151regulation of gamma-delta T cell differentiation (GO:0045586)3.37877098
152respiratory burst (GO:0045730)3.36925352
153myeloid cell activation involved in immune response (GO:0002275)3.36218976
154negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.29608759
155negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.20123207
156negative regulation of leukocyte mediated immunity (GO:0002704)3.16661123
157regulation of interleukin-6 biosynthetic process (GO:0045408)3.14997734
158negative regulation of T cell mediated immunity (GO:0002710)3.14210249
159antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.12001255
160positive regulation of mast cell activation (GO:0033005)3.11979213
161regulation of mast cell activation (GO:0033003)3.11508734
162neural tube formation (GO:0001841)3.10203679
163positive regulation of toll-like receptor signaling pathway (GO:0034123)3.08188303
164leukocyte aggregation (GO:0070486)3.07549231
165B cell receptor signaling pathway (GO:0050853)3.07475139
166positive regulation of interferon-alpha production (GO:0032727)3.05549913
167regulation of germinal center formation (GO:0002634)3.05001560
168negative regulation of adaptive immune response (GO:0002820)3.03082162
169superoxide anion generation (GO:0042554)3.02795799
170negative regulation of T-helper cell differentiation (GO:0045623)2.97948245
171negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.97948245
172regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.95999670
173negative regulation of cAMP-mediated signaling (GO:0043951)2.95212135
174defense response to protozoan (GO:0042832)2.93897503
175immunoglobulin mediated immune response (GO:0016064)2.92006224
176regulation of interferon-alpha production (GO:0032647)2.89544571
177regulation of MHC class II biosynthetic process (GO:0045346)2.85413799
178regulation of mast cell activation involved in immune response (GO:0033006)2.84181832
179interferon-gamma production (GO:0032609)2.80623102
180regulation of mast cell degranulation (GO:0043304)2.79715615
181regulation of memory T cell differentiation (GO:0043380)2.79149559
182negative regulation of humoral immune response (GO:0002921)2.77707229
183positive regulation of interleukin-1 beta secretion (GO:0050718)2.76813234
184activated T cell proliferation (GO:0050798)2.76037492
185germinal center formation (GO:0002467)2.74345671
186negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.73641417
187response to type I interferon (GO:0034340)2.73289601
188negative regulation of interleukin-1 production (GO:0032692)2.72008747
189epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.71742183
190cellular response to type I interferon (GO:0071357)2.70363591
191type I interferon signaling pathway (GO:0060337)2.70363591
192dendritic cell migration (GO:0036336)2.67995230
193tolerance induction (GO:0002507)2.67890275
194neutrophil chemotaxis (GO:0030593)2.64975686
195positive regulation of interferon-beta production (GO:0032728)2.64384078
196positive regulation of mast cell activation involved in immune response (GO:0033008)2.63973224
197positive regulation of mast cell degranulation (GO:0043306)2.63973224
198regulation of tolerance induction (GO:0002643)2.63087081
199positive regulation of interleukin-1 secretion (GO:0050716)2.62793981
200negative regulation of alpha-beta T cell activation (GO:0046636)2.62269858

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.17204908
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.97442548
3* EGR1_23403033_ChIP-Seq_LIVER_Mouse6.68709582
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.39069730
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.34926216
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.23671728
7* CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.01267674
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.89013399
9* CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.77484886
10IRF8_21731497_ChIP-ChIP_J774_Mouse3.48785259
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.36680460
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.08481620
13SMAD_19615063_ChIP-ChIP_OVARY_Human2.61887562
14RUNX_20019798_ChIP-Seq_JUKART_Human2.23946374
15BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.21162236
16MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.21131941
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.18295338
18GBX2_23144817_ChIP-Seq_PC3_Human2.11519705
19TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.11303687
20BP1_19119308_ChIP-ChIP_Hs578T_Human2.08593319
21TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.05381842
22ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.6377248
23HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.95532154
24STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.89787055
25VDR_24787735_ChIP-Seq_THP-1_Human1.86493793
26SCL_19346495_ChIP-Seq_HPC-7_Human1.75116227
27CLOCK_20551151_ChIP-Seq_293T_Human1.72408844
28POU3F2_20337985_ChIP-ChIP_501MEL_Human1.69497301
29SPI1_23127762_ChIP-Seq_K562_Human1.68621533
30CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.62706020
31MYB_26560356_Chip-Seq_TH2_Human1.59774724
32MYB_21317192_ChIP-Seq_ERMYB_Mouse1.58167117
33* FOXA2_19822575_ChIP-Seq_HepG2_Human1.57422813
34GATA1_22025678_ChIP-Seq_K562_Human1.57093549
35ER_23166858_ChIP-Seq_MCF-7_Human1.54752308
36GATA3_26560356_Chip-Seq_TH2_Human1.52991342
37SPI1_23547873_ChIP-Seq_NB4_Human1.50273550
38PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.49256164
39LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.47589293
40THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.47393689
41GATA3_27048872_Chip-Seq_THYMUS_Human1.46287503
42FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.43371721
43CDX2_19796622_ChIP-Seq_MESCs_Mouse1.42868566
44ZFP57_27257070_Chip-Seq_ESCs_Mouse1.42522057
45FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.41997511
46HTT_18923047_ChIP-ChIP_STHdh_Human1.41260424
47STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.39290152
48FLI1_27457419_Chip-Seq_LIVER_Mouse1.35189417
49AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.34898099
50* HNF4A_19822575_ChIP-Seq_HepG2_Human1.34483014
51VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.31752715
52STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.31676976
53DROSHA_22980978_ChIP-Seq_HELA_Human1.31182201
54IRF8_22096565_ChIP-ChIP_GC-B_Human1.30798963
55RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.28668755
56ZNF274_21170338_ChIP-Seq_K562_Hela1.28602368
57TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28441256
58POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.28441256
59IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.26470087
60PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.26222638
61IGF1R_20145208_ChIP-Seq_DFB_Human1.25830754
62SMRT_27268052_Chip-Seq_Bcells_Human1.25220495
63GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24974957
64SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.24921365
65GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22129170
66STAT3_23295773_ChIP-Seq_U87_Human1.21087848
67ESR1_15608294_ChIP-ChIP_MCF-7_Human1.20786381
68PRDM14_20953172_ChIP-Seq_ESCs_Human1.17884793
69CTBP2_25329375_ChIP-Seq_LNCAP_Human1.17563721
70TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.16692084
71SUZ12_27294783_Chip-Seq_NPCs_Mouse1.15815788
72SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15545738
73MYB_26560356_Chip-Seq_TH1_Human1.15476936
74P300_19829295_ChIP-Seq_ESCs_Human1.14976818
75VDR_22108803_ChIP-Seq_LS180_Human1.14776490
76GATA2_21666600_ChIP-Seq_HMVEC_Human1.14764676
77GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.14365118
78RXRA_24833708_ChIP-Seq_LIVER_Mouse1.13759699
79NFE2_27457419_Chip-Seq_LIVER_Mouse1.12768093
80CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.12528992
81UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11819575
82TP53_16413492_ChIP-PET_HCT116_Human1.10786308
83PCGF2_27294783_Chip-Seq_ESCs_Mouse1.10544925
84PIAS1_25552417_ChIP-Seq_VCAP_Human1.10400448
85* EZH2_27294783_Chip-Seq_NPCs_Mouse1.09974642
86RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.08191380
87ARNT_22903824_ChIP-Seq_MCF-7_Human1.07850701
88SMAD4_21799915_ChIP-Seq_A2780_Human1.07825554
89E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.06534495
90TAF15_26573619_Chip-Seq_HEK293_Human1.06019890
91NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05766601
92RARG_19884340_ChIP-ChIP_MEFs_Mouse1.05764270
93LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.05328530
94EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.05250345
95TCF4_23295773_ChIP-Seq_U87_Human1.03314646
96VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.01494840
97CTBP1_25329375_ChIP-Seq_LNCAP_Human1.01072562
98Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.00231923
99VDR_24763502_ChIP-Seq_THP-1_Human0.99867133
100SOX2_27498859_Chip-Seq_STOMACH_Mouse0.99341891
101* FLI1_21867929_ChIP-Seq_TH2_Mouse0.99285021
102ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99222124
103AHR_22903824_ChIP-Seq_MCF-7_Human0.95686840
104SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.95145361
105CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.94804465
106GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.93387962
107* OCT4_21477851_ChIP-Seq_ESCs_Mouse0.92652522
108SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.92178150
109RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.90973029
110CBP_20019798_ChIP-Seq_JUKART_Human0.90569171
111IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.90569171
112PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89514382
113* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.89507324
114TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.88360939
115RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87802377
116SMAD3_21741376_ChIP-Seq_EPCs_Human0.87778554
117NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.87487236
118RUNX2_22187159_ChIP-Seq_PCA_Human0.87417810
119PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.87230321
120GATA4_25053715_ChIP-Seq_YYC3_Human0.86802958
121TP63_23658742_ChIP-Seq_EP156T_Human0.86414802
122MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.86276861
123* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.84685769
124CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.84548378
125ZNF263_19887448_ChIP-Seq_K562_Human0.80480675
126ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.77031379
127SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.76953561
128ESR2_21235772_ChIP-Seq_MCF-7_Human0.74288491
129* AUTS2_25519132_ChIP-Seq_293T-REX_Human0.73796157
130NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.72533714
131NRF2_20460467_ChIP-Seq_MEFs_Mouse0.72533714
132SALL4_18804426_ChIP-ChIP_XEN_Mouse0.71136220
133RARA_24833708_ChIP-Seq_LIVER_Mouse0.70797830
134SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.69659603
135ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.69238438
136* KAP1_22055183_ChIP-Seq_ESCs_Mouse0.68088458
137AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.67219618
138PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.66783702
139EGR1_19032775_ChIP-ChIP_M12_Human0.63791233
140BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.63377302
141RAD21_21589869_ChIP-Seq_MESCs_Mouse0.61761678
142NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.61495234
143LXR_22292898_ChIP-Seq_THP-1_Human0.60893359
144RARB_24833708_ChIP-Seq_LIVER_Mouse0.58648734
145CEBPB_22108803_ChIP-Seq_LS180_Human0.58584611
146GATA1_19941826_ChIP-Seq_K562_Human0.55568291
147NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.53861759
148PPAR_26484153_Chip-Seq_NCI-H1993_Human0.53473439
149PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.52634096
150* FOXA1_25552417_ChIP-Seq_VCAP_Human0.51977962
151ESR1_20079471_ChIP-ChIP_T-47D_Human0.51636781
152ESR1_21235772_ChIP-Seq_MCF-7_Human0.51597594
153* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.51498532
154GATA2_19941826_ChIP-Seq_K562_Human0.51229664
155PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.51223835
156STAT3_1855785_ChIP-Seq_MESCs_Mouse0.51179836
157AR_20517297_ChIP-Seq_VCAP_Human0.50322827
158MYC_19915707_ChIP-ChIP_AK7_Human0.49575387
159GATA1_19941827_ChIP-Seq_MEL_Mouse0.48963777
160PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.48896040
161FOXO3_23340844_ChIP-Seq_DLD1_Human0.48779994
162CDX2_20551321_ChIP-Seq_CACO-2_Human0.48667050
163SOX2_20726797_ChIP-Seq_SW620_Human0.47683737
164FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.46587121
165ESET_19884257_ChIP-Seq_ESCs_Mouse0.46290064
166* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.46077422
167STAT1_17558387_ChIP-Seq_HELA_Human0.45163215
168SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.44523090
169FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.44494793
170CBP_21632823_ChIP-Seq_H3396_Human0.43529441
171* P53_21459846_ChIP-Seq_SAOS-2_Human0.43369894
172SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.42893729
173GATA6_25053715_ChIP-Seq_YYC3_Human0.42765452
174TAF2_19829295_ChIP-Seq_ESCs_Human0.41879637
175* IRF8_27001747_Chip-Seq_BMDM_Mouse0.41315536
176PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.41166560
177TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.40943566
178BRD4_27068464_Chip-Seq_AML-cells_Mouse0.38688389
179MYC_27129775_Chip-Seq_CORNEA_Mouse0.37129988
180TRIM28_21343339_ChIP-Seq_HEK293_Human0.37129577
181GATA3_24758297_ChIP-Seq_MCF-7_Human0.36424720
182BCOR_27268052_Chip-Seq_Bcells_Human0.36219949
183GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.36120083
184CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.35898534
185CSB_26484114_Chip-Seq_FIBROBLAST_Human0.35692665
186CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.35387053
187STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.35156419
188BCAT_22108803_ChIP-Seq_LS180_Human0.35054903

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.04204249
2MP0005360_urolithiasis7.21012345
3MP0005085_abnormal_gallbladder_physiolo6.18785123
4MP0005365_abnormal_bile_salt6.03253670
5MP0008875_abnormal_xenobiotic_pharmacok5.15312372
6MP0003806_abnormal_nucleotide_metabolis3.85991498
7MP0003252_abnormal_bile_duct3.71511292
8MP0010329_abnormal_lipoprotein_level3.63941635
9MP0009840_abnormal_foam_cell3.42808982
10MP0003303_peritoneal_inflammation3.38750466
11MP0000569_abnormal_digit_pigmentation3.16917358
12MP0005083_abnormal_biliary_tract3.13112215
13MP0001835_abnormal_antigen_presentation3.05148771
14MP0003195_calcinosis2.79904262
15MP0003191_abnormal_cellular_cholesterol2.68737348
16MP0005332_abnormal_amino_acid2.68559605
17MP0002132_abnormal_respiratory_system2.67357911
18MP0001800_abnormal_humoral_immune2.60029542
19MP0005671_abnormal_response_to2.56252712
20MP0001666_abnormal_nutrient_absorption2.46012072
21MP0002277_abnormal_respiratory_mucosa2.28021966
22MP0002723_abnormal_immune_serum2.25256390
23MP0005000_abnormal_immune_tolerance2.22058839
24MP0000609_abnormal_liver_physiology2.20803441
25MP0001790_abnormal_immune_system2.16157614
26MP0005387_immune_system_phenotype2.16157614
27MP0000685_abnormal_immune_system2.15254893
28MP0004019_abnormal_vitamin_homeostasis2.14894544
29MP0002118_abnormal_lipid_homeostasis2.14558203
30MP0002452_abnormal_antigen_presenting2.12403169
31MP0002420_abnormal_adaptive_immunity2.08467798
32MP0001819_abnormal_immune_cell2.06049323
33MP0002138_abnormal_hepatobiliary_system2.01439587
34MP0002148_abnormal_hypersensitivity_rea1.96725217
35MP0004381_abnormal_hair_follicle1.90359372
36MP0003183_abnormal_peptide_metabolism1.85178984
37MP0005319_abnormal_enzyme/_coenzyme1.83681563
38MP0002653_abnormal_ependyma_morphology1.82758459
39MP0003868_abnormal_feces_composition1.79444230
40MP0003172_abnormal_lysosome_physiology1.79073487
41MP0002405_respiratory_system_inflammati1.76542358
42MP0003787_abnormal_imprinting1.75110545
43MP0001533_abnormal_skeleton_physiology1.72027508
44MP0001764_abnormal_homeostasis1.68644592
45MP0005310_abnormal_salivary_gland1.63196052
46MP0005584_abnormal_enzyme/coenzyme_acti1.57080437
47MP0005451_abnormal_body_composition1.56785696
48MP0000465_gastrointestinal_hemorrhage1.55360857
49MP0000716_abnormal_immune_system1.50358398
50MP0003011_delayed_dark_adaptation1.49961940
51MP0003646_muscle_fatigue1.49917928
52MP0009697_abnormal_copulation1.47466441
53MP0009278_abnormal_bone_marrow1.43286246
54MP0003186_abnormal_redox_activity1.42721875
55MP0008260_abnormal_autophagy1.42170814
56MP0003828_pulmonary_edema1.41458408
57MP0002398_abnormal_bone_marrow1.38874483
58MP0003656_abnormal_erythrocyte_physiolo1.38396201
59MP0003300_gastrointestinal_ulcer1.34618288
60MP0003763_abnormal_thymus_physiology1.32954260
61MP0010155_abnormal_intestine_physiology1.27289581
62MP0001545_abnormal_hematopoietic_system1.27216214
63MP0005397_hematopoietic_system_phenotyp1.27216214
64MP0000689_abnormal_spleen_morphology1.25232560
65MP0003866_abnormal_defecation1.24951283
66MP0009643_abnormal_urine_homeostasis1.24614520
67MP0000604_amyloidosis1.22813492
68MP0003705_abnormal_hypodermis_morpholog1.22555020
69MP0000598_abnormal_liver_morphology1.20092676
70MP0009764_decreased_sensitivity_to1.19702301
71MP0002254_reproductive_system_inflammat1.18640892
72MP0008004_abnormal_stomach_pH1.17499394
73MP0002722_abnormal_immune_system1.16160058
74MP0008877_abnormal_DNA_methylation1.16096329
75MP0003045_fibrosis1.13842986
76MP0005670_abnormal_white_adipose1.10547682
77MP0005075_abnormal_melanosome_morpholog1.10288117
78MP0009763_increased_sensitivity_to1.09101203
79MP0005174_abnormal_tail_pigmentation1.05813974
80MP0002429_abnormal_blood_cell1.05555567
81MP0002396_abnormal_hematopoietic_system1.04444299
82MP0005647_abnormal_sex_gland1.03139111
83MP0008469_abnormal_protein_level0.99688919
84MP0003878_abnormal_ear_physiology0.98356033
85MP0005377_hearing/vestibular/ear_phenot0.98356033
86MP0001968_abnormal_touch/_nociception0.98229273
87MP0010368_abnormal_lymphatic_system0.95674910
88MP0005636_abnormal_mineral_homeostasis0.91445058
89MP0006054_spinal_hemorrhage0.90133432
90MP0009642_abnormal_blood_homeostasis0.89115766
91MP0004484_altered_response_of0.89018208
92MP0000703_abnormal_thymus_morphology0.87569092
93MP0000015_abnormal_ear_pigmentation0.87475925
94MP0004130_abnormal_muscle_cell0.86794126
95MP0001501_abnormal_sleep_pattern0.86701097
96MP0002332_abnormal_exercise_endurance0.86555456
97MP0001851_eye_inflammation0.86510395
98MP0004947_skin_inflammation0.85090464
99MP0002876_abnormal_thyroid_physiology0.81890183
100MP0005376_homeostasis/metabolism_phenot0.81644731
101MP0005408_hypopigmentation0.81558751
102MP0002736_abnormal_nociception_after0.81463122
103MP0008057_abnormal_DNA_replication0.81239146
104MP0002971_abnormal_brown_adipose0.81097792
105MP0002078_abnormal_glucose_homeostasis0.80603610
106MP0003690_abnormal_glial_cell0.80110446
107MP0009765_abnormal_xenobiotic_induced0.80029285
108MP0001663_abnormal_digestive_system0.79768209
109MP0005334_abnormal_fat_pad0.76459833
110MP0006036_abnormal_mitochondrial_physio0.74270017
111MP0003436_decreased_susceptibility_to0.73912441
112MP0003724_increased_susceptibility_to0.72583287
113MP0000427_abnormal_hair_cycle0.71549679
114MP0005464_abnormal_platelet_physiology0.70710311
115MP0005535_abnormal_body_temperature0.70651008
116MP0003221_abnormal_cardiomyocyte_apopto0.70345007
117MP0000371_diluted_coat_color0.70173222
118MP0009333_abnormal_splenocyte_physiolog0.69158207
119MP0005084_abnormal_gallbladder_morpholo0.67451367
120MP0002166_altered_tumor_susceptibility0.67000089
121MP0001986_abnormal_taste_sensitivity0.66823020
122MP0002693_abnormal_pancreas_physiology0.66474682
123MP0005220_abnormal_exocrine_pancreas0.65112195
124MP0001661_extended_life_span0.64857788
125MP0003329_amyloid_beta_deposits0.64725239
126MP0004043_abnormal_pH_regulation0.64084618
127MP0001756_abnormal_urination0.63830629
128MP0004782_abnormal_surfactant_physiolog0.62022464
129MP0000639_abnormal_adrenal_gland0.61611229
130MP0003075_altered_response_to0.61093009
131MP0005448_abnormal_energy_balance0.60073157
132MP0005266_abnormal_metabolism0.59227881
133MP0009053_abnormal_anal_canal0.58051514
134MP0005666_abnormal_adipose_tissue0.56451181
135MP0002837_dystrophic_cardiac_calcinosis0.54246185
136MP0002136_abnormal_kidney_physiology0.51451903
137MP0005395_other_phenotype0.50153589
138MP0003638_abnormal_response/metabolism_0.48123315
139MP0008873_increased_physiological_sensi0.47329687
140MP0009115_abnormal_fat_cell0.46112598
141MP0005167_abnormal_blood-brain_barrier0.45874109
142MP0006035_abnormal_mitochondrial_morpho0.45592509
143MP0004883_abnormal_blood_vessel0.45366461
144MP0005166_decreased_susceptibility_to0.44983089
145MP0008874_decreased_physiological_sensi0.44904508
146MP0009785_altered_susceptibility_to0.44891689
147MP0005058_abnormal_lysosome_morphology0.44309043
148MP0005164_abnormal_response_to0.43392355
149MP0000249_abnormal_blood_vessel0.42216746
150MP0001845_abnormal_inflammatory_respons0.41941572
151MP0006082_CNS_inflammation0.41248545
152MP0001853_heart_inflammation0.40614237
153MP0003953_abnormal_hormone_level0.40077957
154MP0005248_abnormal_Harderian_gland0.39784413
155MP0008872_abnormal_physiological_respon0.38822627
156MP0002928_abnormal_bile_duct0.37690309
157MP0003718_maternal_effect0.37492619
158MP0002168_other_aberrant_phenotype0.36963231
159MP0002796_impaired_skin_barrier0.36709185
160MP0002970_abnormal_white_adipose0.36451484
161MP0001881_abnormal_mammary_gland0.35545137
162MP0002822_catalepsy0.35520297
163MP0001243_abnormal_dermal_layer0.35418950
164MP0002419_abnormal_innate_immunity0.33499743
165MP0000230_abnormal_systemic_arterial0.33049023
166MP0005025_abnormal_response_to0.31922743
167MP0002060_abnormal_skin_morphology0.30184798
168MP0009672_abnormal_birth_weight0.29828392

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.39461509
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.27559967
3Intrahepatic cholestasis (HP:0001406)6.93538697
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.57087224
5Prolonged partial thromboplastin time (HP:0003645)6.55647955
6Xanthomatosis (HP:0000991)6.33427086
7Hypobetalipoproteinemia (HP:0003563)6.24415635
8Hyperlipoproteinemia (HP:0010980)5.66461862
9Retrobulbar optic neuritis (HP:0100654)5.44745882
10Optic neuritis (HP:0100653)5.44745882
11Myositis (HP:0100614)5.44177980
12Orchitis (HP:0100796)5.39326927
13Complement deficiency (HP:0004431)5.19067520
14Recurrent bacterial skin infections (HP:0005406)5.11926053
15Recurrent abscess formation (HP:0002722)4.94872068
16Joint hemorrhage (HP:0005261)4.91547004
17Hypolipoproteinemia (HP:0010981)4.86757563
18Dynein arm defect of respiratory motile cilia (HP:0012255)4.77052685
19Absent/shortened dynein arms (HP:0200106)4.77052685
20Eczematoid dermatitis (HP:0000976)4.59704831
21Abnormality of the common coagulation pathway (HP:0010990)4.55067774
22Hyperammonemia (HP:0001987)4.54589879
23Epidermoid cyst (HP:0200040)4.54429876
24Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.48058160
25Stomatitis (HP:0010280)4.47308565
26Hypoalphalipoproteinemia (HP:0003233)4.46751466
27Keratoconjunctivitis sicca (HP:0001097)4.38721892
28Abnormality of methionine metabolism (HP:0010901)4.33969320
29Keratoconjunctivitis (HP:0001096)4.24132810
30Ketosis (HP:0001946)4.19695562
31Abnormality of sulfur amino acid metabolism (HP:0004339)4.16427603
32Abnormality of glutamine family amino acid metabolism (HP:0010902)4.15775318
33Elevated erythrocyte sedimentation rate (HP:0003565)4.13655440
34Abnormality of aspartate family amino acid metabolism (HP:0010899)4.12058007
35Hyperglycinemia (HP:0002154)4.08278599
36Fat malabsorption (HP:0002630)3.84479698
37Abnormality of complement system (HP:0005339)3.83406557
38Abnormality of pyrimidine metabolism (HP:0004353)3.81616126
39Hyperglycinuria (HP:0003108)3.81462271
40Hypoglycemic coma (HP:0001325)3.76309784
41Abnormality of glycine metabolism (HP:0010895)3.72904517
42Abnormality of serine family amino acid metabolism (HP:0010894)3.72904517
43Abnormal ciliary motility (HP:0012262)3.72322625
44Abnormality of the intrinsic pathway (HP:0010989)3.70842354
45Hypercholesterolemia (HP:0003124)3.66121072
46Abnormal respiratory motile cilium morphology (HP:0005938)3.58333399
47Abnormal respiratory epithelium morphology (HP:0012253)3.58333399
48Recurrent fungal infections (HP:0002841)3.56526626
49Gastrointestinal infarctions (HP:0005244)3.49562370
50Abnormality of macrophages (HP:0004311)3.45851684
51Conjugated hyperbilirubinemia (HP:0002908)3.39701639
52Abnormal respiratory motile cilium physiology (HP:0012261)3.38518984
53Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.38409684
54Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.33122514
55Abnormality of fatty-acid metabolism (HP:0004359)3.32752787
56Recurrent skin infections (HP:0001581)3.32137413
57Hyperbilirubinemia (HP:0002904)3.29978162
58Encephalitis (HP:0002383)3.18225599
59Mediastinal lymphadenopathy (HP:0100721)3.10413768
60Abnormality of nucleobase metabolism (HP:0010932)3.09364127
61Abnormal delayed hypersensitivity skin test (HP:0002963)3.04849824
62Spontaneous abortion (HP:0005268)3.03600378
63Meningitis (HP:0001287)3.02956408
64Hepatocellular carcinoma (HP:0001402)3.02520402
65Arterial thrombosis (HP:0004420)3.00935197
66Systemic lupus erythematosus (HP:0002725)3.00003912
67Myocardial infarction (HP:0001658)2.95418367
68Abnormality of T cell number (HP:0011839)2.95379921
69Ketoacidosis (HP:0001993)2.93464203
70Abnormality of serum amino acid levels (HP:0003112)2.90824165
71T lymphocytopenia (HP:0005403)2.90458602
72Delayed CNS myelination (HP:0002188)2.90222571
73Spontaneous hematomas (HP:0007420)2.89069866
74Recurrent cutaneous fungal infections (HP:0011370)2.87969469
75Chronic mucocutaneous candidiasis (HP:0002728)2.87969469
76Steatorrhea (HP:0002570)2.86587821
77Skin nodule (HP:0200036)2.86214374
78Obstructive lung disease (HP:0006536)2.85682924
79Chronic obstructive pulmonary disease (HP:0006510)2.85682924
80Vasculitis (HP:0002633)2.83146425
81Glomerulonephritis (HP:0000099)2.81085924
82Recurrent sinusitis (HP:0011108)2.77766019
83Hemoptysis (HP:0002105)2.77212376
84Chest pain (HP:0100749)2.75694922
85Abnormality of purine metabolism (HP:0004352)2.73238127
86Metabolic acidosis (HP:0001942)2.71455157
87Stomach cancer (HP:0012126)2.67448812
88Episodic fever (HP:0001954)2.66890704
89Hypochromic microcytic anemia (HP:0004840)2.66568166
90Anorexia (HP:0002039)2.64712977
91Amyloidosis (HP:0011034)2.64216670
92Gingivitis (HP:0000230)2.61549436
93Bronchiectasis (HP:0002110)2.61521926
94Hypochromic anemia (HP:0001931)2.57925350
95Vascular calcification (HP:0004934)2.57132743
96Acanthocytosis (HP:0001927)2.56853916
97Recurrent gram-negative bacterial infections (HP:0005420)2.56281398
98Prolonged bleeding time (HP:0003010)2.54136550
99Lethargy (HP:0001254)2.54062244
100Keratitis (HP:0000491)2.53095207
101Gout (HP:0001997)2.51762019
102Dicarboxylic aciduria (HP:0003215)2.50932832
103Abnormality of dicarboxylic acid metabolism (HP:0010995)2.50932832
104Gangrene (HP:0100758)2.50710873
105Peritonitis (HP:0002586)2.50299753
106Rhinitis (HP:0012384)2.49632812
107Leukocytosis (HP:0001974)2.49004759
108Urticaria (HP:0001025)2.46245553
109Pancreatic cysts (HP:0001737)2.46149505
110Abnormal gallbladder morphology (HP:0012437)2.45936622
111Spastic diplegia (HP:0001264)2.43515080
112Absent rod-and cone-mediated responses on ERG (HP:0007688)2.43333412
113Gingival bleeding (HP:0000225)2.39601046
114Recurrent bronchitis (HP:0002837)2.39075216
115Mitral stenosis (HP:0001718)2.38136402
116Cholelithiasis (HP:0001081)2.37978870
117Pulmonary infiltrates (HP:0002113)2.37822594
118Irritability (HP:0000737)2.37069935
119Cerebral edema (HP:0002181)2.36298802
120Hypoglycemic seizures (HP:0002173)2.36278902
121Esophageal varix (HP:0002040)2.34553146
122Menorrhagia (HP:0000132)2.31191258
123Cholecystitis (HP:0001082)2.29306534
124Abnormal gallbladder physiology (HP:0012438)2.29306534
125Cardiovascular calcification (HP:0011915)2.29024782
126Increased IgE level (HP:0003212)2.27744955
127Decreased central vision (HP:0007663)2.27641237
128Abnormality of T cells (HP:0002843)2.24081114
129Pancreatic fibrosis (HP:0100732)2.23160014
130Attenuation of retinal blood vessels (HP:0007843)2.22803978
131Neonatal onset (HP:0003623)2.22022619
132True hermaphroditism (HP:0010459)2.21776410
133Abnormality of the pleura (HP:0002103)2.21499304
134Nasal polyposis (HP:0100582)2.21438642
135Pancreatitis (HP:0001733)2.18811977
136Bronchitis (HP:0012387)2.17920313
137Constricted visual fields (HP:0001133)2.16201337
138Epistaxis (HP:0000421)2.15732650
139Thrombophlebitis (HP:0004418)2.15587733
140Brushfield spots (HP:0001088)2.11227021
141Genetic anticipation (HP:0003743)2.10738692
142Hemorrhage of the eye (HP:0011885)2.10153391
143Vertigo (HP:0002321)2.09925383
144Congenital stationary night blindness (HP:0007642)2.08970011
145Abnormality of iron homeostasis (HP:0011031)2.08149385
146Subacute progressive viral hepatitis (HP:0006572)2.07814063
147Eosinophilia (HP:0001880)2.05696933
148Enlarged kidneys (HP:0000105)2.04474274
149Sensorimotor neuropathy (HP:0007141)2.03141494
150Neoplasm of the tracheobronchial system (HP:0100552)2.02905905
151Abolished electroretinogram (ERG) (HP:0000550)2.02848375
152Vomiting (HP:0002013)2.02782303
153Chronic otitis media (HP:0000389)2.02704557
154Malnutrition (HP:0004395)2.02680579
155Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.02055631
156Nephritis (HP:0000123)2.01924544
157Late onset (HP:0003584)2.00905029
158Abnormality of transition element cation homeostasis (HP:0011030)2.00637742
159Chronic sinusitis (HP:0011109)2.00553420
160Poikilocytosis (HP:0004447)2.00500119
161Generalized aminoaciduria (HP:0002909)1.97920226
162Abnormality of the gallbladder (HP:0005264)1.96747045
163Abnormality of proline metabolism (HP:0010907)1.96671550
164Hydroxyprolinuria (HP:0003080)1.96671550
165Recurrent pneumonia (HP:0006532)1.95981033
166Abnormal rod and cone electroretinograms (HP:0008323)1.94567696
167Abnormal cartilage morphology (HP:0002763)1.94168397
168Opisthotonus (HP:0002179)1.89972878
169Hypertriglyceridemia (HP:0002155)1.88883332
170Rickets (HP:0002748)1.87923088
171Chronic bronchitis (HP:0004469)1.87149545
172Autoimmune hemolytic anemia (HP:0001890)1.86860405
173Granulocytopenia (HP:0001913)1.86495094
174Hyperinsulinemic hypoglycemia (HP:0000825)1.86321557
175Decreased electroretinogram (ERG) amplitude (HP:0000654)1.85913214
176Abnormality of eosinophils (HP:0001879)1.84076048
177Sepsis (HP:0100806)1.83711768
178Thyroiditis (HP:0100646)1.83120690
179Microcytic anemia (HP:0001935)1.81506841
180Elevated hepatic transaminases (HP:0002910)1.81402445
181Abnormality of T cell physiology (HP:0011840)1.81349727
182Alkalosis (HP:0001948)1.80886588
183Abnormal enzyme/coenzyme activity (HP:0012379)1.79938672
184Abnormality of the peritoneum (HP:0002585)1.79751556
185Hypophosphatemic rickets (HP:0004912)1.78823387
186Abnormality of midbrain morphology (HP:0002418)1.77726734
187Molar tooth sign on MRI (HP:0002419)1.77726734
188Abnormality of the endocardium (HP:0004306)1.77544204
189Pulmonary embolism (HP:0002204)1.77092295
190Bony spicule pigmentary retinopathy (HP:0007737)1.76574068
191Renal cortical cysts (HP:0000803)1.75570883
192Autoimmune thrombocytopenia (HP:0001973)1.75386155
193Pustule (HP:0200039)1.75031999
194Gaze-evoked nystagmus (HP:0000640)1.74493188
195Increased purine levels (HP:0004368)1.73912764

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.70810443
2SIK14.34581651
3FGFR44.31478384
4ERN14.29483631
5RIPK43.79897012
6IRAK43.28792887
7MST1R2.73680637
8INSRR2.68952833
9TAOK32.63383655
10ERBB42.47428933
11PKN22.35883198
12TRIB32.13107575
13TXK2.12209718
14FES2.07778070
15TYK22.02705703
16MAP2K42.02575892
17TNK22.01372585
18FLT31.85814150
19DAPK21.83400199
20MAPK111.72924512
21ACVR1B1.69572726
22PTK2B1.66817549
23IRAK21.65961043
24LATS11.56269217
25PTK61.55493514
26FGR1.50867381
27SYK1.47907331
28PIK3CG1.46145470
29TBK11.44981078
30HCK1.44823045
31ABL21.44212853
32BTK1.43479743
33NEK91.41289726
34FRK1.36140743
35TAOK11.35846910
36LYN1.33739846
37FGFR21.32060834
38JAK21.30183264
39MAP3K141.29976179
40KDR1.29199002
41ADRBK21.26846128
42EPHB11.25418591
43JAK11.23754568
44CAMK1D1.21447846
45TEC1.20411037
46MAPK131.19592738
47YES11.16179241
48PRKAA21.15359817
49MAP2K31.14430606
50GRK61.10122682
51BMPR21.06011292
52MARK31.05372637
53MAP3K31.04152771
54CSK1.03947301
55MET1.03379551
56MATK1.02494085
57OXSR11.02133963
58EPHA30.96352895
59ERBB20.96087285
60MAP3K70.95044616
61MAPK40.94711773
62TGFBR20.93999933
63RIPK10.92658443
64WNK30.92587171
65MAP3K100.88844503
66LCK0.87071822
67NLK0.86317873
68SIK20.86262351
69PINK10.86163427
70PBK0.85039141
71PRKCZ0.84984158
72IKBKE0.83059576
73MAP3K110.82684219
74STK380.81398971
75CAMKK20.80713837
76CDK60.79154488
77NUAK10.78991241
78ADRBK10.78478138
79PRKACG0.77769222
80MAPK120.76393863
81IRAK30.76362216
82TIE10.75878210
83KSR20.74777452
84FGFR30.74326645
85STK110.74193389
86SIK30.72619966
87TLK10.69575022
88GRK70.69485337
89CDK190.67638788
90PAK30.66684340
91STK38L0.66663970
92PTK20.65861474
93GSK3A0.64775551
94CSF1R0.63258825
95MAPK150.61885147
96PDPK10.59215198
97GRK50.58523664
98PRKAA10.57818484
99MAP4K20.57479107
100CAMK2G0.57191004
101RAF10.55552484
102MAP2K60.55200435
103DYRK1B0.54149715
104IGF1R0.52947108
105MAP2K10.50112070
106CAMK1G0.49971771
107SGK30.49737760
108STK100.49710274
109GRK10.48918330
110MARK20.48874521
111HIPK20.47957200
112FYN0.47230127
113KSR10.46763073
114MAP3K130.45776899
115PRKCQ0.43611687
116EGFR0.43304415
117RET0.43224659
118ZAP700.42982383
119MAPK70.42851299
120PIM10.41838939
121DYRK30.41017876
122BMX0.40693828
123SGK2230.40394428
124SGK4940.40394428
125BLK0.39695616
126CSNK1G10.38214599
127CDK40.37479509
128MAP3K50.37073784
129PDK10.36728889
130BMPR1B0.36434528
131DYRK1A0.35570164
132CAMK40.34751659
133SGK10.34004619
134MAP3K60.32451307
135MAP3K10.32076574
136IRAK10.31890160
137EPHB20.31618863
138KIT0.30725624
139MAP4K10.29463559
140ABL10.27799878
141TAOK20.27575547
142MAP3K20.26661802
143SGK20.26426542
144MTOR0.26031522
145MAP2K20.25670084
146JAK30.25530220
147CHUK0.25287947
148PKN10.25188194
149EPHA20.24128888
150PRKCA0.24073207
151STK30.23901467
152ITK0.23466580
153IKBKB0.22901747

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.37259849
2Nitrogen metabolism_Homo sapiens_hsa009103.67214503
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.39770487
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.29694554
5Arginine biosynthesis_Homo sapiens_hsa002203.07502233
6Complement and coagulation cascades_Homo sapiens_hsa046102.84711268
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.71524646
8Leishmaniasis_Homo sapiens_hsa051402.66166510
9Tryptophan metabolism_Homo sapiens_hsa003802.62296326
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.55069721
11Fatty acid degradation_Homo sapiens_hsa000712.50445913
12Osteoclast differentiation_Homo sapiens_hsa043802.46835163
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.46206643
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.34518872
15NOD-like receptor signaling pathway_Homo sapiens_hsa046212.27463331
16Pentose and glucuronate interconversions_Homo sapiens_hsa000402.23368673
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.17638444
18Peroxisome_Homo sapiens_hsa041462.09359598
19Butanoate metabolism_Homo sapiens_hsa006502.06623582
20Staphylococcus aureus infection_Homo sapiens_hsa051502.03581188
21Graft-versus-host disease_Homo sapiens_hsa053322.02813734
22Chemical carcinogenesis_Homo sapiens_hsa052042.02771458
23Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.01251331
24Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.99808607
25PPAR signaling pathway_Homo sapiens_hsa033201.99625905
26Tuberculosis_Homo sapiens_hsa051521.98867316
27Propanoate metabolism_Homo sapiens_hsa006401.92691349
28Caffeine metabolism_Homo sapiens_hsa002321.92395942
29Histidine metabolism_Homo sapiens_hsa003401.90959190
30Fatty acid metabolism_Homo sapiens_hsa012121.87054042
31Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.84783658
32Steroid hormone biosynthesis_Homo sapiens_hsa001401.84243493
33Toll-like receptor signaling pathway_Homo sapiens_hsa046201.74749235
34Allograft rejection_Homo sapiens_hsa053301.74649162
35beta-Alanine metabolism_Homo sapiens_hsa004101.73887537
36Primary immunodeficiency_Homo sapiens_hsa053401.71443622
37B cell receptor signaling pathway_Homo sapiens_hsa046621.70936014
38Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.70668076
39Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.68684417
40Drug metabolism - other enzymes_Homo sapiens_hsa009831.67127031
41Retinol metabolism_Homo sapiens_hsa008301.64509956
42Phenylalanine metabolism_Homo sapiens_hsa003601.64210928
43Autoimmune thyroid disease_Homo sapiens_hsa053201.61354070
44Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.59877112
45Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.55764546
46Hematopoietic cell lineage_Homo sapiens_hsa046401.54700426
47Measles_Homo sapiens_hsa051621.53952723
48Selenocompound metabolism_Homo sapiens_hsa004501.53282981
49Chemokine signaling pathway_Homo sapiens_hsa040621.51396164
50NF-kappa B signaling pathway_Homo sapiens_hsa040641.51082211
51Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.49552309
52Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.49086985
53Jak-STAT signaling pathway_Homo sapiens_hsa046301.48018490
542-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.47631077
55Bile secretion_Homo sapiens_hsa049761.44044405
56Tyrosine metabolism_Homo sapiens_hsa003501.42668607
57Intestinal immune network for IgA production_Homo sapiens_hsa046721.40909641
58Type I diabetes mellitus_Homo sapiens_hsa049401.37896125
59Pyruvate metabolism_Homo sapiens_hsa006201.35321783
60Fatty acid elongation_Homo sapiens_hsa000621.34123811
61Sulfur metabolism_Homo sapiens_hsa009201.33882859
62Cysteine and methionine metabolism_Homo sapiens_hsa002701.28568814
63Starch and sucrose metabolism_Homo sapiens_hsa005001.27017018
64Dorso-ventral axis formation_Homo sapiens_hsa043201.24243183
65T cell receptor signaling pathway_Homo sapiens_hsa046601.21523464
66Steroid biosynthesis_Homo sapiens_hsa001001.20607300
67Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.20510108
68Influenza A_Homo sapiens_hsa051641.20212835
69TNF signaling pathway_Homo sapiens_hsa046681.19839439
70Fat digestion and absorption_Homo sapiens_hsa049751.19499116
71ABC transporters_Homo sapiens_hsa020101.18626626
72Folate biosynthesis_Homo sapiens_hsa007901.16402017
73Biosynthesis of amino acids_Homo sapiens_hsa012301.16221427
74Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.15868788
75Toxoplasmosis_Homo sapiens_hsa051451.12733227
76Carbon metabolism_Homo sapiens_hsa012001.12574653
77Platelet activation_Homo sapiens_hsa046111.05513617
78Antigen processing and presentation_Homo sapiens_hsa046121.01347241
79Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.00457007
80Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.98536558
81Phagosome_Homo sapiens_hsa041450.97685332
82Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.94910193
83Carbohydrate digestion and absorption_Homo sapiens_hsa049730.93879987
84Herpes simplex infection_Homo sapiens_hsa051680.93682706
85Arginine and proline metabolism_Homo sapiens_hsa003300.93640373
86Acute myeloid leukemia_Homo sapiens_hsa052210.92903091
87Sulfur relay system_Homo sapiens_hsa041220.92694778
88Asthma_Homo sapiens_hsa053100.90501832
89Maturity onset diabetes of the young_Homo sapiens_hsa049500.89467976
90Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.88328684
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.87554330
92Olfactory transduction_Homo sapiens_hsa047400.86951365
93Vitamin digestion and absorption_Homo sapiens_hsa049770.86887017
94Phototransduction_Homo sapiens_hsa047440.86628563
95Cyanoamino acid metabolism_Homo sapiens_hsa004600.86211240
96Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.84919599
97Ether lipid metabolism_Homo sapiens_hsa005650.84576389
98Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.82738541
99Rheumatoid arthritis_Homo sapiens_hsa053230.80381649
100Leukocyte transendothelial migration_Homo sapiens_hsa046700.77582123
101Vitamin B6 metabolism_Homo sapiens_hsa007500.77578876
102Lysine degradation_Homo sapiens_hsa003100.75802057
103Hepatitis B_Homo sapiens_hsa051610.74812925
104Glycerolipid metabolism_Homo sapiens_hsa005610.71970309
105Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70707461
106Prolactin signaling pathway_Homo sapiens_hsa049170.70510430
107Glutathione metabolism_Homo sapiens_hsa004800.70148000
108SNARE interactions in vesicular transport_Homo sapiens_hsa041300.68814814
109Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.68421076
110Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.67472201
111Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.66519186
112Fatty acid biosynthesis_Homo sapiens_hsa000610.66362575
113Non-small cell lung cancer_Homo sapiens_hsa052230.65809071
114FoxO signaling pathway_Homo sapiens_hsa040680.65320096
115Type II diabetes mellitus_Homo sapiens_hsa049300.65083810
116Choline metabolism in cancer_Homo sapiens_hsa052310.64845472
117Pentose phosphate pathway_Homo sapiens_hsa000300.64378506
118Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.63942986
119Serotonergic synapse_Homo sapiens_hsa047260.63601672
120One carbon pool by folate_Homo sapiens_hsa006700.63398829
121Morphine addiction_Homo sapiens_hsa050320.61959689
122Phosphatidylinositol signaling system_Homo sapiens_hsa040700.58757797
123Viral myocarditis_Homo sapiens_hsa054160.58322960
124Salmonella infection_Homo sapiens_hsa051320.52711119
125Sphingolipid signaling pathway_Homo sapiens_hsa040710.51746253
126Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.47545262
127Phospholipase D signaling pathway_Homo sapiens_hsa040720.47227548
128Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47014687
129cAMP signaling pathway_Homo sapiens_hsa040240.46508127
130Transcriptional misregulation in cancer_Homo sapiens_hsa052020.45786232
131Apoptosis_Homo sapiens_hsa042100.44221620
132Metabolic pathways_Homo sapiens_hsa011000.43573900
133MAPK signaling pathway_Homo sapiens_hsa040100.41483900
134Inositol phosphate metabolism_Homo sapiens_hsa005620.41308396
135Cholinergic synapse_Homo sapiens_hsa047250.39681469
136Pancreatic cancer_Homo sapiens_hsa052120.39542638
137Long-term depression_Homo sapiens_hsa047300.38729396
138Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.35683412
139Adipocytokine signaling pathway_Homo sapiens_hsa049200.30873052
140Prion diseases_Homo sapiens_hsa050200.30294826
141Insulin resistance_Homo sapiens_hsa049310.28002373
142Fructose and mannose metabolism_Homo sapiens_hsa000510.25199632
143alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.24915309
144Galactose metabolism_Homo sapiens_hsa000520.24264458
145Linoleic acid metabolism_Homo sapiens_hsa005910.23346073
146Glycerophospholipid metabolism_Homo sapiens_hsa005640.16040512
147Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.15517427
148Glucagon signaling pathway_Homo sapiens_hsa049220.09400780
149AMPK signaling pathway_Homo sapiens_hsa041520.05711902
150Thyroid hormone synthesis_Homo sapiens_hsa04918-0.2146182
151Legionellosis_Homo sapiens_hsa05134-0.2009909
152RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.1980786
153Amoebiasis_Homo sapiens_hsa05146-0.1929794
154Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1839689
155Lysosome_Homo sapiens_hsa04142-0.1825227
156Malaria_Homo sapiens_hsa05144-0.1788738
157Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1707267
158Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1695367
159Regulation of autophagy_Homo sapiens_hsa04140-0.1664640
160Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1533750
161Renin-angiotensin system_Homo sapiens_hsa04614-0.1512021
162Hepatitis C_Homo sapiens_hsa05160-0.1322957
163Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1192480
164Pertussis_Homo sapiens_hsa05133-0.0990025
165Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0892799
166Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0838878
167Insulin signaling pathway_Homo sapiens_hsa04910-0.0815406
168Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0645638
169African trypanosomiasis_Homo sapiens_hsa05143-0.0451282
170Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0210853

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