VOPP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1retinal cone cell development (GO:0046549)5.66990212
2regulation of rhodopsin mediated signaling pathway (GO:0022400)5.66686842
3rhodopsin mediated signaling pathway (GO:0016056)5.48670368
4regulation of short-term neuronal synaptic plasticity (GO:0048172)5.44404680
5synaptic vesicle maturation (GO:0016188)5.00765942
6photoreceptor cell development (GO:0042461)4.99906676
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.98674643
8retinal rod cell development (GO:0046548)4.78784257
9layer formation in cerebral cortex (GO:0021819)4.70265783
10eye photoreceptor cell development (GO:0042462)4.68131330
11protein localization to synapse (GO:0035418)4.63724676
12synaptic vesicle docking involved in exocytosis (GO:0016081)4.59537297
13antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.53458034
14antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.48488063
15regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.47152523
16positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.42005016
17photoreceptor cell maintenance (GO:0045494)4.36271854
18synaptic vesicle exocytosis (GO:0016079)4.33413547
19regulation of synaptic vesicle exocytosis (GO:2000300)4.28120669
20antigen processing and presentation of endogenous antigen (GO:0019883)4.24687974
21vocalization behavior (GO:0071625)4.21564606
22locomotory exploration behavior (GO:0035641)4.19249137
23NIK/NF-kappaB signaling (GO:0038061)4.18653755
24glutamate secretion (GO:0014047)4.07738254
25regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.99917184
26phototransduction (GO:0007602)3.85350772
27negative regulation of cell killing (GO:0031342)3.83594334
28negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.83594334
29regulation of glutamate receptor signaling pathway (GO:1900449)3.81366057
30regulation of clathrin-mediated endocytosis (GO:2000369)3.72742631
31detection of light stimulus (GO:0009583)3.72615204
32protein localization to endosome (GO:0036010)3.70260623
33regulation of synaptic vesicle transport (GO:1902803)3.70153296
34detection of light stimulus involved in visual perception (GO:0050908)3.66261248
35detection of light stimulus involved in sensory perception (GO:0050962)3.66261248
36neuron cell-cell adhesion (GO:0007158)3.62340928
37regulation of dendritic cell antigen processing and presentation (GO:0002604)3.58323336
38neuron recognition (GO:0008038)3.56966974
39B cell receptor signaling pathway (GO:0050853)3.56094029
40antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.54438390
41axonal fasciculation (GO:0007413)3.50283200
42positive regulation of gamma-delta T cell activation (GO:0046645)3.47711467
43regulation of synapse structural plasticity (GO:0051823)3.47534624
44regulation of B cell receptor signaling pathway (GO:0050855)3.46885760
45phototransduction, visible light (GO:0007603)3.44213328
46dendritic spine morphogenesis (GO:0060997)3.44116309
47modulation by symbiont of host defense response (GO:0052031)3.43606255
48modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.43606255
49modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.43606255
50positive regulation by organism of defense response of other organism involved in symbiotic interact3.43606255
51modulation by symbiont of host immune response (GO:0052553)3.43606255
52positive regulation by symbiont of host defense response (GO:0052509)3.43606255
53detection of visible light (GO:0009584)3.42705289
54dendrite morphogenesis (GO:0048813)3.41495244
55exploration behavior (GO:0035640)3.41000149
56regulation of interferon-beta biosynthetic process (GO:0045357)3.34025334
57cellular potassium ion homeostasis (GO:0030007)3.31022601
58myeloid dendritic cell differentiation (GO:0043011)3.29601614
59positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.27519738
60germinal center formation (GO:0002467)3.25909775
61regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.24841094
62pyrimidine nucleobase catabolic process (GO:0006208)3.23098571
63visual perception (GO:0007601)3.20915357
64innervation (GO:0060384)3.17302006
65interferon-gamma-mediated signaling pathway (GO:0060333)3.16990264
66sensory perception of light stimulus (GO:0050953)3.16804205
67photoreceptor cell differentiation (GO:0046530)3.16621738
68eye photoreceptor cell differentiation (GO:0001754)3.16621738
69positive regulation of guanylate cyclase activity (GO:0031284)3.14920874
70positive regulation of synapse maturation (GO:0090129)3.14001802
71cellular response to type I interferon (GO:0071357)3.13786124
72type I interferon signaling pathway (GO:0060337)3.13786124
73neurotransmitter secretion (GO:0007269)3.12136801
74regulation of type I interferon-mediated signaling pathway (GO:0060338)3.12135364
75response to type I interferon (GO:0034340)3.10798164
76macrophage activation involved in immune response (GO:0002281)3.08684155
77response to peptidoglycan (GO:0032494)3.08179957
78cell migration in hindbrain (GO:0021535)3.07874668
79sodium ion export (GO:0071436)3.06199249
80ionotropic glutamate receptor signaling pathway (GO:0035235)3.05449203
81dopamine receptor signaling pathway (GO:0007212)3.05001241
82barbed-end actin filament capping (GO:0051016)3.04700863
83regulation of antigen processing and presentation (GO:0002577)3.04248518
84activation of protein kinase A activity (GO:0034199)3.04099865
85regulation of long-term neuronal synaptic plasticity (GO:0048169)3.02788264
86immunoglobulin mediated immune response (GO:0016064)3.01060499
87modulation by symbiont of host cellular process (GO:0044068)3.00998972
88synaptic vesicle endocytosis (GO:0048488)3.00356058
89membrane hyperpolarization (GO:0060081)2.99874842
90regulation of neuronal synaptic plasticity (GO:0048168)2.99638790
91positive regulation of neurotransmitter transport (GO:0051590)2.98536840
92regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.97866275
93response to pheromone (GO:0019236)2.97112886
94positive regulation of Cdc42 GTPase activity (GO:0043089)2.95233157
95detection of other organism (GO:0098543)2.94168884
96positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.93981997
97B cell homeostasis (GO:0001782)2.93698213
98positive regulation of neurotransmitter secretion (GO:0001956)2.93160917
99regulation of neurotransmitter secretion (GO:0046928)2.91116873
100regulation of postsynaptic membrane potential (GO:0060078)2.88553661
101regulation of early endosome to late endosome transport (GO:2000641)2.88322734
102positive regulation of membrane potential (GO:0045838)2.87992886
103axon extension (GO:0048675)2.87894670
104central nervous system projection neuron axonogenesis (GO:0021952)2.86618554
105detection of bacterium (GO:0016045)2.86265464
106myeloid dendritic cell activation (GO:0001773)2.85580876
107clathrin coat assembly (GO:0048268)2.85382326
108regulation of voltage-gated calcium channel activity (GO:1901385)2.84871312
109nucleobase catabolic process (GO:0046113)2.83068666
110positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.82862862
111glutamate receptor signaling pathway (GO:0007215)2.82451199
112lipopolysaccharide-mediated signaling pathway (GO:0031663)2.82376218
113regulation of excitatory postsynaptic membrane potential (GO:0060079)2.82357243
114synaptic transmission, glutamatergic (GO:0035249)2.82305276
115postsynaptic membrane organization (GO:0001941)2.82130119
116regulation of vesicle fusion (GO:0031338)2.81944783
117neurotransmitter-gated ion channel clustering (GO:0072578)2.81310708
118B cell proliferation (GO:0042100)2.81022856
119peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.80061356
120response to muramyl dipeptide (GO:0032495)2.78965279
121protein-chromophore linkage (GO:0018298)2.78475493
122regulation of superoxide anion generation (GO:0032928)2.75874712
123T cell costimulation (GO:0031295)2.74935296
124CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.74535086
125T-helper 1 type immune response (GO:0042088)2.74343566
126stress fiber assembly (GO:0043149)2.74023147
127response to auditory stimulus (GO:0010996)2.73137670
128proline transport (GO:0015824)2.72567517
129negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.71687745
130positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.71000347
131establishment of nucleus localization (GO:0040023)2.70406376
132detection of external stimulus (GO:0009581)2.70152265
133lymphocyte costimulation (GO:0031294)2.69201793
134cerebellar Purkinje cell differentiation (GO:0021702)2.67886006
135neuron-neuron synaptic transmission (GO:0007270)2.67721389
136regulation of defense response to virus by virus (GO:0050690)2.66704074
137pinocytosis (GO:0006907)2.65863956
138retina development in camera-type eye (GO:0060041)2.65626319
139Golgi transport vesicle coating (GO:0048200)2.65438626
140COPI coating of Golgi vesicle (GO:0048205)2.65438626
141positive regulation of cellular amide metabolic process (GO:0034250)2.65193117
142regulation of guanylate cyclase activity (GO:0031282)2.65188151
143response to histamine (GO:0034776)2.65108199
144vesicle transport along microtubule (GO:0047496)2.64970509
145synapse assembly (GO:0007416)2.64660947
146negative regulation of interleukin-12 production (GO:0032695)2.64332103
147G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.64223577
148detection of abiotic stimulus (GO:0009582)2.63869826
149cell communication by electrical coupling (GO:0010644)2.63829885
150GMP metabolic process (GO:0046037)2.62740030
151organelle transport along microtubule (GO:0072384)2.62667559
152regulation of T-helper 1 cell differentiation (GO:0045625)2.62420442
153activation of MAPKKK activity (GO:0000185)2.60730731
154positive regulation of vesicle fusion (GO:0031340)2.57459731
155T cell migration (GO:0072678)2.57009815
156behavioral fear response (GO:0001662)2.56399593
157behavioral defense response (GO:0002209)2.56399593
158adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.55137590
159positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.54904448
160negative regulation of microtubule polymerization (GO:0031115)2.54720586
161long-term synaptic potentiation (GO:0060291)2.54486549
162neuron projection extension (GO:1990138)2.54144284
163dendritic cell differentiation (GO:0097028)2.53265875
164positive regulation of Rap GTPase activity (GO:0032854)2.53071314
165positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.51345179
166defense response to protozoan (GO:0042832)2.50634552
167activation of Rac GTPase activity (GO:0032863)2.48635473
168cell adhesion mediated by integrin (GO:0033627)2.48580751
169positive regulation of type 2 immune response (GO:0002830)2.48197186
170negative regulation of erythrocyte differentiation (GO:0045647)2.46785110
171endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.46280172
172positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.45324669
173Fc receptor mediated stimulatory signaling pathway (GO:0002431)2.45125844
174Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)2.45055168
175immune response-regulating cell surface receptor signaling pathway involved in phagocytosis (GO:00022.45055168
176Fc-gamma receptor signaling pathway (GO:0038094)2.45055168
177regulation of extracellular matrix disassembly (GO:0010715)2.44351995
178response to laminar fluid shear stress (GO:0034616)2.44343066
179cellular response to interferon-gamma (GO:0071346)2.43200487
180negative regulation of toll-like receptor signaling pathway (GO:0034122)2.41641270
181detection of external biotic stimulus (GO:0098581)2.41384088
182thymic T cell selection (GO:0045061)2.40083147
183regulation of T-helper 2 cell differentiation (GO:0045628)2.39377713
184positive regulation of antigen processing and presentation (GO:0002579)2.37495323
185regulation of anoikis (GO:2000209)2.36483773
186regulation of protein heterodimerization activity (GO:0043497)2.35806585
187negative regulation of anoikis (GO:2000811)2.34836077
188signal complex assembly (GO:0007172)2.34562014
189positive regulation of interferon-alpha production (GO:0032727)2.34206934
190response to host (GO:0075136)2.32879391
191response to host defenses (GO:0052200)2.32879391
192response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.32879391
193positive thymic T cell selection (GO:0045059)2.32638028
194B cell mediated immunity (GO:0019724)2.32327900
195N-acetylneuraminate metabolic process (GO:0006054)2.31780946
196modulation by virus of host process (GO:0019054)2.31676737
197mannose metabolic process (GO:0006013)2.31169377
198antigen processing and presentation via MHC class Ib (GO:0002475)2.30990715
199negative regulation of bone resorption (GO:0045779)2.29248492
200glycosphingolipid catabolic process (GO:0046479)2.28240534

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.83148109
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.76711785
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.58677844
4* MYC_22102868_ChIP-Seq_BL_Human3.40601056
5TP63_17297297_ChIP-ChIP_HaCaT_Human3.20722940
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.18741623
7NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.98192376
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.79936923
9GBX2_23144817_ChIP-Seq_PC3_Human2.79649339
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.76566691
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.70288231
12IRF8_21731497_ChIP-ChIP_J774_Mouse2.57915654
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.56217469
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.56217469
15NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.47841423
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.44845996
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.43768649
18VDR_21846776_ChIP-Seq_THP-1_Human2.43387602
19* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.42407725
20SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.40868821
21EZH2_27304074_Chip-Seq_ESCs_Mouse2.39294045
22* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.34461758
23* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.33912465
24MTF2_20144788_ChIP-Seq_MESCs_Mouse2.32755818
25RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.29398766
26SUZ12_27294783_Chip-Seq_ESCs_Mouse2.29308017
27ELK3_25401928_ChIP-Seq_HUVEC_Human2.28564746
28* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.27224074
29SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.26377527
30THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.25824778
31DROSHA_22980978_ChIP-Seq_HELA_Human2.22343137
32EZH2_27294783_Chip-Seq_ESCs_Mouse2.18597258
33RNF2_27304074_Chip-Seq_ESCs_Mouse2.18062640
34STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.14675075
35CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.14343230
36LXR_22292898_ChIP-Seq_THP-1_Human2.13545211
37IRF8_27001747_Chip-Seq_BMDM_Mouse2.12717864
38EED_16625203_ChIP-ChIP_MESCs_Mouse2.11378512
39REST_21632747_ChIP-Seq_MESCs_Mouse2.09014133
40* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.07190905
41TCF7_22412390_ChIP-Seq_EML_Mouse2.05365630
42KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.99311056
43RARB_27405468_Chip-Seq_BRAIN_Mouse1.95618442
44MAF_26560356_Chip-Seq_TH1_Human1.94521535
45IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.87213770
46STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.85096125
47RARG_19884340_ChIP-ChIP_MEFs_Mouse1.85031305
48BRD4_27068464_Chip-Seq_AML-cells_Mouse1.81850973
49IKZF1_21737484_ChIP-ChIP_HCT116_Human1.80953854
50VDR_24763502_ChIP-Seq_THP-1_Human1.80525576
51SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.79971201
52ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.79891630
53KDM2B_26808549_Chip-Seq_DND41_Human1.78388710
54EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.77917219
55STAT4_19710469_ChIP-ChIP_TH1__Mouse1.76387267
56IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.75828798
57AR_21572438_ChIP-Seq_LNCaP_Human1.75741239
58* RUNX1_22412390_ChIP-Seq_EML_Mouse1.71979601
59REST_18959480_ChIP-ChIP_MESCs_Mouse1.68081487
60RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.66143910
61KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.64680715
62Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.64491558
63FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.62036470
64NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.61388005
65KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.60578557
66CLOCK_20551151_ChIP-Seq_293T_Human1.60362660
67GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.60342977
68NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.57933985
69PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.57852718
70TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.57791360
71RACK7_27058665_Chip-Seq_MCF-7_Human1.57729601
72KDM2B_26808549_Chip-Seq_K562_Human1.56078536
73SMAD_19615063_ChIP-ChIP_OVARY_Human1.51945428
74CTBP2_25329375_ChIP-Seq_LNCAP_Human1.51852279
75SPI1_23127762_ChIP-Seq_K562_Human1.49887870
76IGF1R_20145208_ChIP-Seq_DFB_Human1.49378179
77RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.49291676
78TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.48457183
79PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.47957635
80RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.47930497
81BP1_19119308_ChIP-ChIP_Hs578T_Human1.45513323
82RING1B_27294783_Chip-Seq_NPCs_Mouse1.44506136
83TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.44350232
84EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.44130579
85UTX_26944678_Chip-Seq_JUKART_Human1.42936363
86P300_27058665_Chip-Seq_ZR-75-30cells_Human1.41884998
87SPI1_23547873_ChIP-Seq_NB4_Human1.41116558
88MAF_26560356_Chip-Seq_TH2_Human1.40168093
89WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.39851054
90ERG_21242973_ChIP-ChIP_JURKAT_Human1.39802683
91RING1B_27294783_Chip-Seq_ESCs_Mouse1.39528860
92ZNF217_24962896_ChIP-Seq_MCF-7_Human1.39233354
93* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.39141678
94MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.38327685
95KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.38192570
96SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.36386383
97* SMAD4_21799915_ChIP-Seq_A2780_Human1.35366298
98MYB_26560356_Chip-Seq_TH1_Human1.34899089
99ZNF274_21170338_ChIP-Seq_K562_Hela1.34256494
100VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.33548784
101MYB_26560356_Chip-Seq_TH2_Human1.31681707
102TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31057365
103CBX2_27304074_Chip-Seq_ESCs_Mouse1.30602821
104CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.29870445
105CDX2_19796622_ChIP-Seq_MESCs_Mouse1.28763498
106AR_19668381_ChIP-Seq_PC3_Human1.27378268
107RUNX_20019798_ChIP-Seq_JUKART_Human1.25012772
108TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24528814
109* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.23489957
110PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.22857384
111CTBP1_25329375_ChIP-Seq_LNCAP_Human1.21669420
112GATA1_19941827_ChIP-Seq_MEL_Mouse1.21288576
113SOX2_21211035_ChIP-Seq_LN229_Gbm1.20894045
114NR3C1_23031785_ChIP-Seq_PC12_Mouse1.20872499
115P300_19829295_ChIP-Seq_ESCs_Human1.20452161
116WT1_25993318_ChIP-Seq_PODOCYTE_Human1.19811538
117STAT6_21828071_ChIP-Seq_BEAS2B_Human1.19786131
118ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.19602352
119YAP1_20516196_ChIP-Seq_MESCs_Mouse1.19347381
120SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.18393571
121TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.18220420
122ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.17854899
123* P53_22127205_ChIP-Seq_FIBROBLAST_Human1.17003791
124AHR_22903824_ChIP-Seq_MCF-7_Human1.16232328
125GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15075286
126ZFP281_18757296_ChIP-ChIP_E14_Mouse1.14307985
127TFEB_21752829_ChIP-Seq_HELA_Human1.13933671
128EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.12724624
129DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.12026112
130MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.11547888
131CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.11317684
132CTCF_27219007_Chip-Seq_ERYTHROID_Human1.10832069
133AR_25329375_ChIP-Seq_VCAP_Human1.10761135
134SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.10604873
135SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.10604873
136ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.10241229
137UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.10105818
138* ARNT_22903824_ChIP-Seq_MCF-7_Human1.09607249
139PU_27001747_Chip-Seq_BMDM_Mouse1.08859082
140SMAD3_21741376_ChIP-Seq_EPCs_Human1.08665611
141POU3F2_20337985_ChIP-ChIP_501MEL_Human1.08197492
142* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.08174084
143ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.06899509
144KDM2B_26808549_Chip-Seq_SUP-B15_Human1.05376246
145CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05355425
146* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.05265446
147TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.05084893
148GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04437825
149* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.03707501
150DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.03525202
151SMAD3_21741376_ChIP-Seq_HESCs_Human1.02821530
152AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.02811845
153KDM2B_26808549_Chip-Seq_JURKAT_Human1.02455795
154* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.02019467
155NCOR1_26117541_ChIP-Seq_K562_Human1.01743054
156FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.01577089
157OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01384111
158PIAS1_25552417_ChIP-Seq_VCAP_Human1.01355875
159TRIM28_21343339_ChIP-Seq_HEK293_Human1.01260723
160TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01089099
161* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00699501
162EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.00543818
163STAT3_23295773_ChIP-Seq_U87_Human1.00127788
164TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.00127314
165SCL_19346495_ChIP-Seq_HPC-7_Human0.99560984
166SRY_22984422_ChIP-ChIP_TESTIS_Rat0.99517892
167DNAJC2_21179169_ChIP-ChIP_NT2_Human0.99442880
168SMAD4_21741376_ChIP-Seq_HESCs_Human0.98847769
169ATF3_27146783_Chip-Seq_COLON_Human0.97878679
170OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.97691295
171ESR2_21235772_ChIP-Seq_MCF-7_Human0.97333035
172PU.1_20513432_ChIP-Seq_Bcells_Mouse0.97240411
173SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96836442
174HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.96566613
175* RNF2_27304074_Chip-Seq_NSC_Mouse0.96433864
176POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.96002434
177TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96002434
178TP53_20018659_ChIP-ChIP_R1E_Mouse0.95394361
179ZFP281_27345836_Chip-Seq_ESCs_Mouse0.95165808
180* SMAD3_21741376_ChIP-Seq_ESCs_Human0.93802234
181GATA2_21666600_ChIP-Seq_HMVEC_Human0.93636586
182KLF4_18555785_ChIP-Seq_MESCs_Mouse0.93093318
183SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.92503183
184ZFP57_27257070_Chip-Seq_ESCs_Mouse0.91956636
185EP300_21415370_ChIP-Seq_HL-1_Mouse0.90983984
186NR3C1_21868756_ChIP-Seq_MCF10A_Human0.90574210
187PRDM14_20953172_ChIP-Seq_ESCs_Human0.90195731
188TP53_16413492_ChIP-PET_HCT116_Human0.89991141

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005551_abnormal_eye_electrophysiolog5.09299625
2MP0004859_abnormal_synaptic_plasticity4.84594131
3MP0003011_delayed_dark_adaptation4.00608229
4MP0006072_abnormal_retinal_apoptosis3.60432674
5MP0005253_abnormal_eye_physiology3.43482113
6MP0000685_abnormal_immune_system3.28570002
7MP0001835_abnormal_antigen_presentation3.17335995
8MP0003300_gastrointestinal_ulcer3.16251847
9MP0005423_abnormal_somatic_nervous3.08414305
10MP0003880_abnormal_central_pattern3.05168558
11MP0003635_abnormal_synaptic_transmissio3.02414289
12MP0003705_abnormal_hypodermis_morpholog2.91957932
13MP0004270_analgesia2.88823317
14MP0001790_abnormal_immune_system2.84510741
15MP0005387_immune_system_phenotype2.84510741
16MP0003436_decreased_susceptibility_to2.60930893
17MP0002063_abnormal_learning/memory/cond2.53263794
18MP0000569_abnormal_digit_pigmentation2.41664165
19MP0003091_abnormal_cell_migration2.41617441
20MP0001800_abnormal_humoral_immune2.39852874
21MP0003763_abnormal_thymus_physiology2.36765848
22MP0005000_abnormal_immune_tolerance2.33751193
23MP0005195_abnormal_posterior_eye2.30482701
24MP0001968_abnormal_touch/_nociception2.26971183
25MP0005058_abnormal_lysosome_morphology2.25180361
26MP0005671_abnormal_response_to2.24105468
27MP0001984_abnormal_olfaction2.20150382
28MP0002734_abnormal_mechanical_nocicepti2.18243315
29MP0002452_abnormal_antigen_presenting2.15578231
30MP0010352_gastrointestinal_tract_polyps2.11391870
31MP0009745_abnormal_behavioral_response2.10373871
32MP0000778_abnormal_nervous_system2.09056433
33MP0005451_abnormal_body_composition2.08994559
34MP0002877_abnormal_melanocyte_morpholog1.99405980
35MP0002064_seizures1.98464360
36MP0008438_abnormal_cutaneous_collagen1.95601937
37MP0002723_abnormal_immune_serum1.95495963
38MP0003566_abnormal_cell_adhesion1.95260679
39MP0002184_abnormal_innervation1.94888365
40MP0002090_abnormal_vision1.92545555
41MP0002420_abnormal_adaptive_immunity1.91494900
42MP0001819_abnormal_immune_cell1.90174772
43MP0002148_abnormal_hypersensitivity_rea1.89706050
44MP0004947_skin_inflammation1.88621390
45MP0003191_abnormal_cellular_cholesterol1.86266877
46MP0005025_abnormal_response_to1.85739306
47MP0003172_abnormal_lysosome_physiology1.85500672
48MP0002419_abnormal_innate_immunity1.84072387
49MP0002572_abnormal_emotion/affect_behav1.83914271
50MP0009780_abnormal_chondrocyte_physiolo1.80380840
51MP0002882_abnormal_neuron_morphology1.78881083
52MP0009785_altered_susceptibility_to1.77916612
53MP0001502_abnormal_circadian_rhythm1.76433263
54MP0009840_abnormal_foam_cell1.75628430
55MP0009046_muscle_twitch1.74968586
56MP0001486_abnormal_startle_reflex1.74883096
57MP0010155_abnormal_intestine_physiology1.74626437
58MP0001324_abnormal_eye_pigmentation1.73394247
59MP0004858_abnormal_nervous_system1.72022767
60MP0008260_abnormal_autophagy1.71816161
61MP0002735_abnormal_chemical_nociception1.69772478
62MP0004811_abnormal_neuron_physiology1.66280091
63MP0005391_vision/eye_phenotype1.65266468
64MP0002229_neurodegeneration1.60543420
65MP0001853_heart_inflammation1.60442822
66MP0009333_abnormal_splenocyte_physiolog1.58516380
67MP0003724_increased_susceptibility_to1.56745578
68MP0003075_altered_response_to1.56552391
69MP0002653_abnormal_ependyma_morphology1.56208849
70MP0002736_abnormal_nociception_after1.55602490
71MP0002752_abnormal_somatic_nervous1.55141840
72MP0005499_abnormal_olfactory_system1.54734687
73MP0005394_taste/olfaction_phenotype1.54734687
74MP0002398_abnormal_bone_marrow1.52263973
75MP0003453_abnormal_keratinocyte_physiol1.50916185
76MP0000716_abnormal_immune_system1.50824270
77MP0010386_abnormal_urinary_bladder1.50166052
78MP0000858_altered_metastatic_potential1.49244379
79MP0002272_abnormal_nervous_system1.47872583
80MP0006082_CNS_inflammation1.46327248
81MP0003448_altered_tumor_morphology1.45968383
82MP0005464_abnormal_platelet_physiology1.45146556
83MP0002067_abnormal_sensory_capabilities1.43809400
84MP0002638_abnormal_pupillary_reflex1.43528667
85MP0002733_abnormal_thermal_nociception1.42827822
86MP0002557_abnormal_social/conspecific_i1.42305136
87MP0001533_abnormal_skeleton_physiology1.40716968
88MP0005257_abnormal_intraocular_pressure1.40045457
89MP0001970_abnormal_pain_threshold1.40020346
90MP0001845_abnormal_inflammatory_respons1.38236260
91MP0005187_abnormal_penis_morphology1.36794474
92MP0002405_respiratory_system_inflammati1.35410253
93MP0002998_abnormal_bone_remodeling1.34209908
94MP0008789_abnormal_olfactory_epithelium1.33110899
95MP0001849_ear_inflammation1.32214017
96MP0000604_amyloidosis1.30766639
97MP0003279_aneurysm1.28416865
98MP0001440_abnormal_grooming_behavior1.26573503
99MP0002909_abnormal_adrenal_gland1.25417256
100MP0002429_abnormal_blood_cell1.23474240
101MP0008569_lethality_at_weaning1.23304351
102MP0004885_abnormal_endolymph1.23043976
103MP0006276_abnormal_autonomic_nervous1.22948607
104MP0004924_abnormal_behavior1.21873477
105MP0005386_behavior/neurological_phenoty1.21873477
106MP0000343_altered_response_to1.21268224
107MP0005023_abnormal_wound_healing1.19810230
108MP0001958_emphysema1.18524629
109MP0000465_gastrointestinal_hemorrhage1.18507038
110MP0000955_abnormal_spinal_cord1.15141374
111MP0005623_abnormal_meninges_morphology1.15022692
112MP0002722_abnormal_immune_system1.14910367
113MP0000689_abnormal_spleen_morphology1.14902772
114MP0001501_abnormal_sleep_pattern1.10688261
115MP0002152_abnormal_brain_morphology1.08598063
116MP0004808_abnormal_hematopoietic_stem1.08346015
117MP0001348_abnormal_lacrimal_gland1.08176616
118MP0003690_abnormal_glial_cell1.07304568
119MP0005166_decreased_susceptibility_to1.07060724
120MP0002138_abnormal_hepatobiliary_system1.05974092
121MP0001299_abnormal_eye_distance/1.03714081
122MP0003787_abnormal_imprinting1.03010316
123MP0005248_abnormal_Harderian_gland1.02663890
124MP0010234_abnormal_vibrissa_follicle1.01796794
125MP0002166_altered_tumor_susceptibility1.01681339
126MP0003122_maternal_imprinting1.01675739
127MP0003329_amyloid_beta_deposits1.00958463
128MP0000703_abnormal_thymus_morphology0.99084536
129MP0000490_abnormal_crypts_of0.98942341
130MP0005645_abnormal_hypothalamus_physiol0.98565252
131MP0003879_abnormal_hair_cell0.98414490
132MP0004233_abnormal_muscle_weight0.97485883
133MP0002066_abnormal_motor_capabilities/c0.95796905
134MP0005621_abnormal_cell_physiology0.95642263
135MP0000631_abnormal_neuroendocrine_gland0.93687632
136MP0004510_myositis0.93159230
137MP0008469_abnormal_protein_level0.93136723
138MP0003634_abnormal_glial_cell0.92950272
139MP0003866_abnormal_defecation0.92196520
140MP0001873_stomach_inflammation0.91549534
141MP0003045_fibrosis0.89558310
142MP0008874_decreased_physiological_sensi0.88964828
143MP0002234_abnormal_pharynx_morphology0.87352133
144MP0000249_abnormal_blood_vessel0.86990894
145MP0004742_abnormal_vestibular_system0.85533588
146MP0000767_abnormal_smooth_muscle0.83160084
147MP0003861_abnormal_nervous_system0.81238779
148MP0009764_decreased_sensitivity_to0.80197687
149MP0002060_abnormal_skin_morphology0.80017286
150MP0000537_abnormal_urethra_morphology0.79877637
151MP0003795_abnormal_bone_structure0.79552249
152MP0004883_abnormal_blood_vessel0.78226850
153MP0003633_abnormal_nervous_system0.74592756
154MP0003828_pulmonary_edema0.74570408
155MP0009278_abnormal_bone_marrow0.73634340
156MP0002163_abnormal_gland_morphology0.72571845
157MP0008961_abnormal_basal_metabolism0.71937996
158MP0002254_reproductive_system_inflammat0.71309912
159MP0005165_increased_susceptibility_to0.70929228
160MP0002006_tumorigenesis0.70751545
161MP0005197_abnormal_uvea_morphology0.70463325
162MP0005076_abnormal_cell_differentiation0.69631238
163MP0000920_abnormal_myelination0.68959079
164MP0001663_abnormal_digestive_system0.68948827
165MP0003183_abnormal_peptide_metabolism0.68635449
166MP0005390_skeleton_phenotype0.68437851
167MP0010307_abnormal_tumor_latency0.67924976
168MP0001346_abnormal_lacrimal_gland0.67612308
169MP0004085_abnormal_heartbeat0.67028558
170MP0001216_abnormal_epidermal_layer0.66731303
171MP0000534_abnormal_ureter_morphology0.65903027
172MP0004272_abnormal_basement_membrane0.65716936
173MP0003303_peritoneal_inflammation0.59839892
174MP0000751_myopathy0.59282971
175MP0003890_abnormal_embryonic-extraembry0.59003384
176MP0001963_abnormal_hearing_physiology0.58862665
177MP0002069_abnormal_eating/drinking_beha0.58427559
178MP0003631_nervous_system_phenotype0.57561808
179MP0002751_abnormal_autonomic_nervous0.57102680
180MP0003385_abnormal_body_wall0.56527743
181MP0010030_abnormal_orbit_morphology0.54233084
182MP0005646_abnormal_pituitary_gland0.53664934
183MP0001177_atelectasis0.51875670
184MP0001188_hyperpigmentation0.51664627
185MP0002081_perinatal_lethality0.50944812
186MP0001943_abnormal_respiration0.49912306
187MP0004215_abnormal_myocardial_fiber0.49751419
188MP0005310_abnormal_salivary_gland0.45310841
189MP0002089_abnormal_postnatal_growth/wei0.44842914

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)7.48912386
2Absent rod-and cone-mediated responses on ERG (HP:0007688)7.11540843
3Bony spicule pigmentary retinopathy (HP:0007737)6.61786975
4Abnormal rod and cone electroretinograms (HP:0008323)6.51829078
5Central scotoma (HP:0000603)6.19424665
6Abnormality of macular pigmentation (HP:0008002)5.71790091
7Chorioretinal atrophy (HP:0000533)5.70385261
8Pendular nystagmus (HP:0012043)5.44798925
9Abolished electroretinogram (ERG) (HP:0000550)5.23394232
10Pigmentary retinal degeneration (HP:0001146)5.21708700
11Dyschromatopsia (HP:0007641)5.20039746
12Scotoma (HP:0000575)5.12495496
13Posterior subcapsular cataract (HP:0007787)4.14925312
14Decreased central vision (HP:0007663)3.87677941
15Gastrointestinal stroma tumor (HP:0100723)3.87501795
16Severe visual impairment (HP:0001141)3.74972554
17Vitreoretinal degeneration (HP:0000655)3.73296433
18Type II diabetes mellitus (HP:0005978)3.70964708
19Photophobia (HP:0000613)3.46780194
20Increased corneal curvature (HP:0100692)3.45072276
21Keratoconus (HP:0000563)3.45072276
22Attenuation of retinal blood vessels (HP:0007843)3.42749661
23Cellulitis (HP:0100658)3.41192953
24Eczematoid dermatitis (HP:0000976)3.38337316
25Cone-rod dystrophy (HP:0000548)3.37051988
26Macular degeneration (HP:0000608)3.37021426
27Visual hallucinations (HP:0002367)3.20795722
28Focal motor seizures (HP:0011153)3.20384850
29Agammaglobulinemia (HP:0004432)3.16028225
30Constricted visual fields (HP:0001133)3.15802705
31Epileptic encephalopathy (HP:0200134)3.15142712
32Emphysema (HP:0002097)3.11313418
33Myokymia (HP:0002411)3.04992166
34Abnormality of glycolipid metabolism (HP:0010969)3.04222676
35Abnormality of liposaccharide metabolism (HP:0010968)3.04222676
36Abnormality of glycosphingolipid metabolism (HP:0004343)3.04222676
37Choroideremia (HP:0001139)3.03487169
38Focal seizures (HP:0007359)2.98293297
39Colitis (HP:0002583)2.97428131
40Abnormality of macrophages (HP:0004311)2.96506502
41Recurrent bacterial skin infections (HP:0005406)2.71757327
42Vertebral compression fractures (HP:0002953)2.71752065
43Febrile seizures (HP:0002373)2.67132131
44Mediastinal lymphadenopathy (HP:0100721)2.66107585
45Recurrent abscess formation (HP:0002722)2.65633585
46Premature rupture of membranes (HP:0001788)2.61710270
47Recurrent viral infections (HP:0004429)2.60804452
48Subcapsular cataract (HP:0000523)2.60434960
49Meningitis (HP:0001287)2.56668781
50Protrusio acetabuli (HP:0003179)2.55551910
51Vasculitis (HP:0002633)2.47410092
52Dysostosis multiplex (HP:0000943)2.44946124
53Mutism (HP:0002300)2.41203943
54Retinitis pigmentosa (HP:0000510)2.40944116
55Lymphopenia (HP:0001888)2.40219546
56Atrophic scars (HP:0001075)2.37751009
57Restrictive lung disease (HP:0002091)2.36492833
58Papilledema (HP:0001085)2.35336637
59Abnormality of cells of the lymphoid lineage (HP:0012140)2.35006475
60Recurrent bronchitis (HP:0002837)2.33947238
61Gastrointestinal inflammation (HP:0004386)2.30592805
62Spontaneous hematomas (HP:0007420)2.30102429
63Osteomyelitis (HP:0002754)2.29111916
64Inflammation of the large intestine (HP:0002037)2.27669678
65Supranuclear gaze palsy (HP:0000605)2.26293708
66IgA deficiency (HP:0002720)2.25825865
67Progressive cerebellar ataxia (HP:0002073)2.25548189
68Increased connective tissue (HP:0009025)2.25267838
69Insomnia (HP:0100785)2.24743029
70Decreased electroretinogram (ERG) amplitude (HP:0000654)2.22808878
71Neurofibrillary tangles (HP:0002185)2.20793994
72Depression (HP:0000716)2.20285348
73Absence seizures (HP:0002121)2.19917058
74Truncal ataxia (HP:0002078)2.19906864
75Inappropriate behavior (HP:0000719)2.18423091
76Progressive visual loss (HP:0000529)2.17867275
77Drooling (HP:0002307)2.17478374
78Excessive salivation (HP:0003781)2.17478374
79Systemic lupus erythematosus (HP:0002725)2.14100806
80Ankle clonus (HP:0011448)2.13026416
81Interstitial pulmonary disease (HP:0006530)2.12409949
82Recurrent sinusitis (HP:0011108)2.10863306
83Increased cerebral lipofuscin (HP:0011813)2.10378445
84Cerebral inclusion bodies (HP:0100314)2.09157455
85Papilloma (HP:0012740)2.08529909
86Verrucae (HP:0200043)2.08529909
87Dilatation of the ascending aorta (HP:0005111)2.07264614
88Fragile skin (HP:0001030)2.06830526
89Osteolytic defects of the phalanges of the hand (HP:0009771)2.05982446
90Osteolytic defects of the hand bones (HP:0009699)2.05982446
91Vascular tortuosity (HP:0004948)2.05873474
92Viral hepatitis (HP:0006562)2.05033721
93Premature loss of primary teeth (HP:0006323)2.04981223
94Hyperparathyroidism (HP:0000843)2.04090799
95Atonic seizures (HP:0010819)2.03351835
96Pulmonary infiltrates (HP:0002113)2.02826439
97Broad-based gait (HP:0002136)2.02261698
98Arterial tortuosity (HP:0005116)2.01505032
99Distal lower limb amyotrophy (HP:0008944)2.00991308
100Urinary glycosaminoglycan excretion (HP:0003541)1.98997507
101Mucopolysacchariduria (HP:0008155)1.98997507
102Syringomyelia (HP:0003396)1.98789564
103Spinal cord lesions (HP:0100561)1.98789564
104Genetic anticipation (HP:0003743)1.98501968
105Centrally nucleated skeletal muscle fibers (HP:0003687)1.97944323
106Gingivitis (HP:0000230)1.97527859
107Recurrent lower respiratory tract infections (HP:0002783)1.96341131
108Generalized tonic-clonic seizures (HP:0002069)1.94006665
109Recurrent fungal infections (HP:0002841)1.93911762
110Loss of speech (HP:0002371)1.92411327
111Recurrent cutaneous fungal infections (HP:0011370)1.92403168
112Chronic mucocutaneous candidiasis (HP:0002728)1.92403168
113Action tremor (HP:0002345)1.90579603
114Macroorchidism (HP:0000053)1.89519874
115Achilles tendon contracture (HP:0001771)1.88880387
116Chronic obstructive pulmonary disease (HP:0006510)1.88275901
117Obstructive lung disease (HP:0006536)1.88275901
118Recurrent pneumonia (HP:0006532)1.87994371
119Spondylolisthesis (HP:0003302)1.87731150
120Abnormality of polysaccharide metabolism (HP:0011012)1.86346952
121Abnormality of glycosaminoglycan metabolism (HP:0004371)1.86346952
122Abnormality of mucopolysaccharide metabolism (HP:0011020)1.86346952
123Recurrent skin infections (HP:0001581)1.85885361
124Gait imbalance (HP:0002141)1.85303574
125Hypoventilation (HP:0002791)1.83707133
126Dialeptic seizures (HP:0011146)1.82305905
127Increased IgE level (HP:0003212)1.82128642
128Amblyopia (HP:0000646)1.81832769
129Wide nasal bridge (HP:0000431)1.80074123
130Dysdiadochokinesis (HP:0002075)1.79782894
131Orchitis (HP:0100796)1.79340507
132Apathy (HP:0000741)1.78829151
133Chronic diarrhea (HP:0002028)1.77408308
134Abnormal delayed hypersensitivity skin test (HP:0002963)1.77288182
135Poor eye contact (HP:0000817)1.76257963
136Aplasia/Hypoplasia of the brainstem (HP:0007362)1.75314644
137Hypoplasia of the brainstem (HP:0002365)1.75314644
138Subacute progressive viral hepatitis (HP:0006572)1.75153973
139Bone pain (HP:0002653)1.75139171
140Abnormality of the nasal mucosa (HP:0000433)1.75117291
141Agitation (HP:0000713)1.74253528
142Upper motor neuron abnormality (HP:0002127)1.73916344
143Abnormality of skeletal muscle fiber size (HP:0012084)1.73609577
144Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.72556296
145Increased variability in muscle fiber diameter (HP:0003557)1.72123085
146Thin bony cortex (HP:0002753)1.71775172
147Nuclear cataract (HP:0100018)1.70841485
148Hypertensive crisis (HP:0100735)1.70758827
149Abnormal social behavior (HP:0012433)1.70018508
150Impaired social interactions (HP:0000735)1.70018508
151Hyperacusis (HP:0010780)1.68017203
152Urinary bladder sphincter dysfunction (HP:0002839)1.67399779
153Cerebral aneurysm (HP:0004944)1.66684552
154Myositis (HP:0100614)1.65817821
155Amyotrophic lateral sclerosis (HP:0007354)1.65757024
156Malnutrition (HP:0004395)1.65395041
157Broad face (HP:0000283)1.64706447
158Persistence of primary teeth (HP:0006335)1.64007500
159Diminished motivation (HP:0000745)1.63625202
160Abnormality of the lower motor neuron (HP:0002366)1.63612273
161Distal lower limb muscle weakness (HP:0009053)1.63594512
162Retinal atrophy (HP:0001105)1.63469269
163Aneurysm (HP:0002617)1.62323677
164Megalencephaly (HP:0001355)1.62155081
165Urinary urgency (HP:0000012)1.62080372
166Myocardial infarction (HP:0001658)1.61691600
167Abnormality of the Achilles tendon (HP:0005109)1.61562092
168Slow saccadic eye movements (HP:0000514)1.60610683
169Skin ulcer (HP:0200042)1.59995283
170Genu recurvatum (HP:0002816)1.59852880
171Pointed chin (HP:0000307)1.57543880
172Absent speech (HP:0001344)1.57297821
173Stereotypic behavior (HP:0000733)1.56100960
174Limb dystonia (HP:0002451)1.55645859
175Lissencephaly (HP:0001339)1.52341136
176Protruding tongue (HP:0010808)1.52190877
177Elfin facies (HP:0004428)1.51267108
178Insidious onset (HP:0003587)1.50730496
179Termporal pattern (HP:0011008)1.50730496
180Impaired vibration sensation in the lower limbs (HP:0002166)1.49862120
181Exotropia (HP:0000577)1.48745086
182Intellectual disability, profound (HP:0002187)1.47965557
183Horizontal nystagmus (HP:0000666)1.47277616
184Anxiety (HP:0000739)1.46779639
185Aqueductal stenosis (HP:0002410)1.46622941
186Open mouth (HP:0000194)1.43577092
187Hemiparesis (HP:0001269)1.43053962
188Abnormality of binocular vision (HP:0011514)1.42231431
189Diplopia (HP:0000651)1.42231431
190Progressive inability to walk (HP:0002505)1.42217343
191Congenital primary aphakia (HP:0007707)1.41269081
192Torticollis (HP:0000473)1.41031447
193Heterotopia (HP:0002282)1.40902095
194Aortic aneurysm (HP:0004942)1.40756396
195Lower limb amyotrophy (HP:0007210)1.40284940
196Hyperventilation (HP:0002883)1.38468289

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.05621166
2TAOK24.19754144
3IRAK33.35523694
4MAP3K93.32784088
5ERN13.20185481
6NTRK32.90475142
7MAP3K42.86968558
8MAP4K12.70897963
9MINK12.58610646
10SIK22.42822076
11DAPK22.25329344
12PAK62.24984630
13SMG12.23382726
14IRAK42.20119735
15EPHA42.14054942
16KSR12.09269173
17MAP3K142.07302662
18TYK22.05909494
19ERBB32.05904002
20MAP2K72.03369899
21NTRK21.99632349
22BLK1.88875476
23CAMKK11.80853646
24FGFR41.79713505
25GRK11.77819895
26EPHB11.65304459
27NME21.62520455
28MAPK131.61652597
29TBK11.56155721
30KSR21.54245653
31MAP3K121.52794212
32CDK51.51916468
33TTN1.50790293
34JAK11.48166465
35SCYL21.47695956
36MAP2K41.46171419
37SIK11.45175977
38TESK11.40612672
39PLK21.40449839
40CASK1.39046682
41RET1.37652303
42RIPK41.29244997
43CAMK1G1.29141151
44RIPK11.29022846
45MAP2K61.25560091
46NEK91.25232316
47PAK31.21045161
48MAP3K81.19560429
49PHKG21.19332378
50PHKG11.19332378
51NTRK11.17152356
52CSK1.13306061
53DAPK11.12924027
54ERBB41.12472151
55CSF1R1.12351140
56JAK31.11387635
57IKBKE1.10757846
58IRAK21.09705032
59MAPK111.08795712
60PAK41.05549351
61PRKD31.03595134
62CDK121.03541825
63MST1R1.02123693
64DDR21.01952687
65DYRK1A0.99702354
66MAP3K100.96015203
67ERBB20.95434154
68GRK50.94778567
69EPHB20.94739821
70MAP3K50.93915545
71ARAF0.93502689
72PRKCH0.92769338
73UHMK10.92601894
74SGK2230.92224665
75SGK4940.92224665
76MAP3K10.92132017
77TYRO30.91922922
78MAP3K20.89909432
79SIK30.89785128
80PRKD20.86896309
81STK380.86060697
82BTK0.85607705
83FGR0.85263607
84SYK0.84928587
85TRIB30.84899796
86DYRK20.84004893
87BMPR20.83986411
88MAP3K30.83205388
89EEF2K0.81249507
90ZAP700.81112766
91IRAK10.80147360
92RPS6KA20.79978814
93STK100.77945079
94CAMK1D0.76858649
95PKN20.76841877
96CSNK1G20.76814733
97TAOK10.76807332
98HCK0.76746867
99PDGFRA0.76329726
100CDK180.76159960
101PRKCZ0.75876416
102CDK140.75111719
103FER0.75068858
104MOS0.74462766
105SGK10.74016368
106SGK30.73672689
107MAP2K30.72858318
108PTK20.72503647
109LATS20.72472211
110STK110.71191927
111CDK150.71041964
112FRK0.69794480
113PRKCG0.68415851
114YES10.67761681
115MAP3K110.67262961
116ADRBK10.67149331
117SGK20.66496356
118ICK0.65401384
119CAMKK20.65284169
120MAPK70.65185504
121CDC42BPA0.63318816
122MAPK120.63190484
123EPHA30.62583606
124CAMK2A0.62313545
125JAK20.61986654
126CDK40.61747555
127PDPK10.61729939
128MELK0.60369297
129FYN0.59216957
130TESK20.57991095
131CDK11A0.57601647
132STK240.57554586
133CCNB10.57309368
134ROCK20.56563446
135LYN0.56291578
136TGFBR20.53576796
137IKBKB0.52795692
138DYRK1B0.52560382
139PDK10.51490984
140MAP3K130.50280581
141CDK60.49184487
142LIMK10.49071378
143HIPK20.47909474
144FGFR20.47728772
145ALK0.47095791
146LMTK20.47088025
147MAP2K10.46639381
148PTK60.45535873
149RPS6KA30.45400739
150DMPK0.45348970
151PRKG20.45183742
152PRKCB0.44294899
153ROCK10.43586019
154PTK2B0.42561054
155TNIK0.42177305
156BCR0.42156557
157PRPF4B0.41962483
158LRRK20.41903301
159MARK20.41875320
160MAPK90.41217029
161FGFR10.41059937
162FES0.40434458
163PRKCE0.40310639
164FGFR30.38464952
165PRKAA10.38060225
166LCK0.37846611
167MTOR0.35978508
168EPHA20.34633520
169MAPK40.33404930
170TRPM70.32410446

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047446.07593124
2Olfactory transduction_Homo sapiens_hsa047402.72964481
3Synaptic vesicle cycle_Homo sapiens_hsa047212.65946967
4B cell receptor signaling pathway_Homo sapiens_hsa046622.44321503
5Allograft rejection_Homo sapiens_hsa053302.40050213
6Leishmaniasis_Homo sapiens_hsa051402.15685540
7Autoimmune thyroid disease_Homo sapiens_hsa053202.14237267
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.11338746
9Nicotine addiction_Homo sapiens_hsa050332.06882327
10Graft-versus-host disease_Homo sapiens_hsa053322.04603801
11Osteoclast differentiation_Homo sapiens_hsa043802.01854560
12GABAergic synapse_Homo sapiens_hsa047271.98317233
13Type I diabetes mellitus_Homo sapiens_hsa049401.94760615
14Toll-like receptor signaling pathway_Homo sapiens_hsa046201.92994755
15Circadian entrainment_Homo sapiens_hsa047131.92681438
16Toxoplasmosis_Homo sapiens_hsa051451.86839437
17Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.84911508
18Morphine addiction_Homo sapiens_hsa050321.80711385
19Asthma_Homo sapiens_hsa053101.77498439
20Glutamatergic synapse_Homo sapiens_hsa047241.74462042
21Dopaminergic synapse_Homo sapiens_hsa047281.72206986
22Other glycan degradation_Homo sapiens_hsa005111.71049009
23Cholinergic synapse_Homo sapiens_hsa047251.69984474
24NF-kappa B signaling pathway_Homo sapiens_hsa040641.69120181
25Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.66039840
26Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.64982305
27Long-term potentiation_Homo sapiens_hsa047201.60056521
28Influenza A_Homo sapiens_hsa051641.58353565
29Staphylococcus aureus infection_Homo sapiens_hsa051501.57778257
30Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.57100596
31Primary immunodeficiency_Homo sapiens_hsa053401.55829062
32Tuberculosis_Homo sapiens_hsa051521.52631826
33Antigen processing and presentation_Homo sapiens_hsa046121.42621163
34Salivary secretion_Homo sapiens_hsa049701.42315251
35Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.41248306
36Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.39472635
37Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.35870097
38Insulin secretion_Homo sapiens_hsa049111.34730114
39TNF signaling pathway_Homo sapiens_hsa046681.33828859
40Oxytocin signaling pathway_Homo sapiens_hsa049211.33785300
41Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.32240660
42Amphetamine addiction_Homo sapiens_hsa050311.32143376
43Hepatitis B_Homo sapiens_hsa051611.30182948
44Acute myeloid leukemia_Homo sapiens_hsa052211.29763784
45Gastric acid secretion_Homo sapiens_hsa049711.28947876
46Phagosome_Homo sapiens_hsa041451.28464952
47Measles_Homo sapiens_hsa051621.27652517
48Serotonergic synapse_Homo sapiens_hsa047261.26472969
49Aldosterone synthesis and secretion_Homo sapiens_hsa049251.25520545
50Renin secretion_Homo sapiens_hsa049241.24101088
51Glioma_Homo sapiens_hsa052141.23169080
52Herpes simplex infection_Homo sapiens_hsa051681.23162317
53Bladder cancer_Homo sapiens_hsa052191.22481580
54Axon guidance_Homo sapiens_hsa043601.20916407
55Shigellosis_Homo sapiens_hsa051311.20224584
56T cell receptor signaling pathway_Homo sapiens_hsa046601.19370493
57Gap junction_Homo sapiens_hsa045401.18948094
58Hepatitis C_Homo sapiens_hsa051601.17477971
59Rheumatoid arthritis_Homo sapiens_hsa053231.15098082
60Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.14569542
61GnRH signaling pathway_Homo sapiens_hsa049121.14236216
62Apoptosis_Homo sapiens_hsa042101.13246216
63Lysosome_Homo sapiens_hsa041421.12856137
64Leukocyte transendothelial migration_Homo sapiens_hsa046701.11276862
65Cocaine addiction_Homo sapiens_hsa050301.05043738
66Endometrial cancer_Homo sapiens_hsa052131.02902598
67RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.00865518
68ErbB signaling pathway_Homo sapiens_hsa040120.99751101
69Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.99087910
70Type II diabetes mellitus_Homo sapiens_hsa049300.98200751
71cGMP-PKG signaling pathway_Homo sapiens_hsa040220.97848122
72Long-term depression_Homo sapiens_hsa047300.95467362
73Estrogen signaling pathway_Homo sapiens_hsa049150.94522846
74cAMP signaling pathway_Homo sapiens_hsa040240.94509920
75Hematopoietic cell lineage_Homo sapiens_hsa046400.93999484
76Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.93614080
77Pertussis_Homo sapiens_hsa051330.92879544
78Collecting duct acid secretion_Homo sapiens_hsa049660.91500200
79Neurotrophin signaling pathway_Homo sapiens_hsa047220.91428574
80Epstein-Barr virus infection_Homo sapiens_hsa051690.91300761
81Taste transduction_Homo sapiens_hsa047420.90035104
82Small cell lung cancer_Homo sapiens_hsa052220.89815388
83Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.89787495
84Prion diseases_Homo sapiens_hsa050200.89449596
85Colorectal cancer_Homo sapiens_hsa052100.88596337
86Dilated cardiomyopathy_Homo sapiens_hsa054140.87872504
87Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.87037900
88Calcium signaling pathway_Homo sapiens_hsa040200.86739588
89Alcoholism_Homo sapiens_hsa050340.86406257
90mTOR signaling pathway_Homo sapiens_hsa041500.85848041
91Phosphatidylinositol signaling system_Homo sapiens_hsa040700.85685275
92Melanogenesis_Homo sapiens_hsa049160.85054939
93VEGF signaling pathway_Homo sapiens_hsa043700.84958285
94Glycosaminoglycan degradation_Homo sapiens_hsa005310.84380497
95Malaria_Homo sapiens_hsa051440.81878169
96HTLV-I infection_Homo sapiens_hsa051660.79942120
97Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.79626209
98Vibrio cholerae infection_Homo sapiens_hsa051100.78698111
99Non-small cell lung cancer_Homo sapiens_hsa052230.77573520
100Thyroid hormone signaling pathway_Homo sapiens_hsa049190.77555122
101Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.77096471
102Renal cell carcinoma_Homo sapiens_hsa052110.76701946
103Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.76486006
104Jak-STAT signaling pathway_Homo sapiens_hsa046300.75105023
105Chronic myeloid leukemia_Homo sapiens_hsa052200.73810375
106Phospholipase D signaling pathway_Homo sapiens_hsa040720.71977556
107Prostate cancer_Homo sapiens_hsa052150.71699744
108Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.71699073
109MAPK signaling pathway_Homo sapiens_hsa040100.70631285
110Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.70575436
111Chemokine signaling pathway_Homo sapiens_hsa040620.70374071
112Viral carcinogenesis_Homo sapiens_hsa052030.68378675
113Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.66441614
114Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.65952313
115Galactose metabolism_Homo sapiens_hsa000520.64957689
116Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.64863762
117Amoebiasis_Homo sapiens_hsa051460.64842094
118Notch signaling pathway_Homo sapiens_hsa043300.64611924
119Regulation of actin cytoskeleton_Homo sapiens_hsa048100.64197130
120Longevity regulating pathway - mammal_Homo sapiens_hsa042110.64185410
121Vascular smooth muscle contraction_Homo sapiens_hsa042700.63666393
122Ras signaling pathway_Homo sapiens_hsa040140.63477831
123Circadian rhythm_Homo sapiens_hsa047100.63326482
124Pentose phosphate pathway_Homo sapiens_hsa000300.62917782
125Pancreatic cancer_Homo sapiens_hsa052120.62645055
126AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.62308433
127Carbohydrate digestion and absorption_Homo sapiens_hsa049730.62278941
128Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.62180568
129MicroRNAs in cancer_Homo sapiens_hsa052060.62179802
130Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.62158022
131Choline metabolism in cancer_Homo sapiens_hsa052310.62126675
132Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61325320
133Oocyte meiosis_Homo sapiens_hsa041140.60501586
134Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60222536
135Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.60089898
136Endocytosis_Homo sapiens_hsa041440.60089529
137Prolactin signaling pathway_Homo sapiens_hsa049170.59984298
138Wnt signaling pathway_Homo sapiens_hsa043100.59494064
139Legionellosis_Homo sapiens_hsa051340.59170466
140Rap1 signaling pathway_Homo sapiens_hsa040150.58836026
141Sphingolipid signaling pathway_Homo sapiens_hsa040710.57996275
142Hippo signaling pathway_Homo sapiens_hsa043900.56765034
143Dorso-ventral axis formation_Homo sapiens_hsa043200.56339690
144HIF-1 signaling pathway_Homo sapiens_hsa040660.55943660
145NOD-like receptor signaling pathway_Homo sapiens_hsa046210.54983022
146Thyroid hormone synthesis_Homo sapiens_hsa049180.54665230
147Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.53603877
148Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.52960386
149African trypanosomiasis_Homo sapiens_hsa051430.52951213
150Fructose and mannose metabolism_Homo sapiens_hsa000510.52443951
151Proteoglycans in cancer_Homo sapiens_hsa052050.52352260
152Focal adhesion_Homo sapiens_hsa045100.52251759
153Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.50119331
154Platelet activation_Homo sapiens_hsa046110.49430716
155Thyroid cancer_Homo sapiens_hsa052160.47942816
156Salmonella infection_Homo sapiens_hsa051320.47724512
157Central carbon metabolism in cancer_Homo sapiens_hsa052300.47685456
158Insulin signaling pathway_Homo sapiens_hsa049100.46033195
159Melanoma_Homo sapiens_hsa052180.45355519
160Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.44941968
161Viral myocarditis_Homo sapiens_hsa054160.43393852
162Inositol phosphate metabolism_Homo sapiens_hsa005620.42742868

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