VPREB3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is the human ortholog of the mouse VpreB3 (8HS20) protein, is thought to be involved in B-cell maturation, and may play a role in assembly of the pre-B cell receptor (pre-BCR). While the role of this protein in B-cell development has not yet been elucidated, studies with the chicken ortholog of this protein have found that when overexpressed, this protein localizes to the endoplasmic reticulum. The mouse ortholog of this protein has been shown to associate with membrane mu heavy chains early in the course of pre-B cell receptor biosynthesis. Expression of this gene has been observed in some lymphomas. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1B cell receptor signaling pathway (GO:0050853)7.57718151
2immunoglobulin mediated immune response (GO:0016064)7.28629713
3V(D)J recombination (GO:0033151)7.04029591
4positive thymic T cell selection (GO:0045059)6.74643872
5regulation of dendritic cell antigen processing and presentation (GO:0002604)6.48733965
6positive regulation of B cell differentiation (GO:0045579)6.36031042
7regulation of antigen processing and presentation of peptide antigen (GO:0002583)6.28510708
8regulation of histone H3-K9 methylation (GO:0051570)5.94872650
9regulation of antigen processing and presentation (GO:0002577)5.88147385
10positive regulation of gamma-delta T cell activation (GO:0046645)5.80404516
11B cell mediated immunity (GO:0019724)5.78301634
12negative regulation of B cell apoptotic process (GO:0002903)5.55724384
13chaperone mediated protein folding requiring cofactor (GO:0051085)5.51437346
14positive regulation of antigen processing and presentation (GO:0002579)5.42380742
15L-serine transport (GO:0015825)5.38384474
16serine transport (GO:0032329)5.32479031
17positive T cell selection (GO:0043368)4.97450998
18negative regulation of histone methylation (GO:0031061)4.94149180
19natural killer cell differentiation (GO:0001779)4.87288725
20positive regulation by host of viral transcription (GO:0043923)4.82960855
21DNA unwinding involved in DNA replication (GO:0006268)4.60353071
22regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022354.49840761
23mucosal-associated lymphoid tissue development (GO:0048537)4.44120999
24Peyers patch development (GO:0048541)4.44120999
25regulation of gamma-delta T cell differentiation (GO:0045586)4.42432280
26regulation of B cell differentiation (GO:0045577)4.36738989
27tachykinin receptor signaling pathway (GO:0007217)4.33829956
28protein-DNA complex disassembly (GO:0032986)4.33823676
29nucleosome disassembly (GO:0006337)4.33823676
30cellular hyperosmotic response (GO:0071474)4.29246097
31DNA topological change (GO:0006265)4.29040314
32protein localization to kinetochore (GO:0034501)4.27421590
33regulation of germinal center formation (GO:0002634)4.26138654
34negative regulation of phagocytosis (GO:0050765)4.19627772
35thymic T cell selection (GO:0045061)4.18260786
36detection of bacterium (GO:0016045)4.15272407
37B cell proliferation (GO:0042100)4.12940441
38regulation of superoxide anion generation (GO:0032928)4.03510485
39negative regulation of thymocyte apoptotic process (GO:0070244)4.01049117
40vesicle targeting (GO:0006903)3.99284690
41regulation of gamma-delta T cell activation (GO:0046643)3.96955976
42interferon-gamma-mediated signaling pathway (GO:0060333)3.96178550
43protein localization to chromosome, centromeric region (GO:0071459)3.94323084
44somatic diversification of immune receptors via germline recombination within a single locus (GO:0003.92479091
45somatic cell DNA recombination (GO:0016444)3.92479091
46negative thymic T cell selection (GO:0045060)3.89808781
47sister chromatid segregation (GO:0000819)3.86177798
48regulation of B cell proliferation (GO:0030888)3.85878054
49positive regulation of B cell proliferation (GO:0030890)3.82632682
50regulation of interferon-beta biosynthetic process (GO:0045357)3.81382699
51somatic diversification of immune receptors (GO:0002200)3.78871257
52detection of other organism (GO:0098543)3.78509855
53ribosomal small subunit assembly (GO:0000028)3.76288171
54T cell selection (GO:0045058)3.66973965
55positive regulation of granulocyte differentiation (GO:0030854)3.65986912
56respiratory burst (GO:0045730)3.64426376
57DNA strand elongation involved in DNA replication (GO:0006271)3.60369661
58antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.58018930
59positive regulation of B cell activation (GO:0050871)3.56615600
60negative T cell selection (GO:0043383)3.55170825
61T cell homeostasis (GO:0043029)3.55132073
62positive regulation of chromosome segregation (GO:0051984)3.54338865
63telomere maintenance via semi-conservative replication (GO:0032201)3.53809076
64DNA ligation (GO:0006266)3.52776047
65hepatocyte apoptotic process (GO:0097284)3.51813513
66positive regulation of gene expression, epigenetic (GO:0045815)3.50636361
67mitotic sister chromatid segregation (GO:0000070)3.47762186
68negative regulation of lymphocyte apoptotic process (GO:0070229)3.47736297
69regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.44423413
70positive regulation of type 2 immune response (GO:0002830)3.41757146
71germinal center formation (GO:0002467)3.41718406
72negative regulation of bone resorption (GO:0045779)3.41716146
73regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.41007694
74type I interferon signaling pathway (GO:0060337)3.41006134
75cellular response to type I interferon (GO:0071357)3.41006134
76T cell costimulation (GO:0031295)3.40606416
77DNA strand elongation (GO:0022616)3.39791248
78response to type I interferon (GO:0034340)3.38677117
79viral transcription (GO:0019083)3.37294400
80positive regulation of histone deacetylation (GO:0031065)3.36559787
81lymphocyte costimulation (GO:0031294)3.35562656
82establishment of integrated proviral latency (GO:0075713)3.34550487
83lens fiber cell development (GO:0070307)3.32616866
84mitotic chromosome condensation (GO:0007076)3.32250225
85response to interferon-beta (GO:0035456)3.31184000
86lymphocyte homeostasis (GO:0002260)3.30697254
87NIK/NF-kappaB signaling (GO:0038061)3.28732859
88mitotic recombination (GO:0006312)3.28138809
89regulation of histone methylation (GO:0031060)3.26761657
90mast cell activation involved in immune response (GO:0002279)3.26750495
91mast cell degranulation (GO:0043303)3.26750495
92immune response-activating cell surface receptor signaling pathway (GO:0002429)3.23591748
93negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 3.23530618
94antigen processing and presentation of endogenous antigen (GO:0019883)3.22014040
95positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.19481861
96positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.18456496
97negative regulation of gene silencing (GO:0060969)3.17981712
98nucleotide-excision repair, DNA gap filling (GO:0006297)3.17457034
99translational termination (GO:0006415)3.15235298
100purine deoxyribonucleotide catabolic process (GO:0009155)3.13646777
101antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.12432581
102antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.12432581
103cellular response to interferon-beta (GO:0035458)3.11925277
104protein localization to chromosome (GO:0034502)3.11285210
105adaptation of signaling pathway (GO:0023058)3.09980830
106telomere maintenance via recombination (GO:0000722)3.09951044
107positive regulation of mitotic sister chromatid separation (GO:1901970)3.09796078
108positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.09796078
109positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.09796078
110ATP-dependent chromatin remodeling (GO:0043044)3.08214130
111mitotic sister chromatid cohesion (GO:0007064)3.07300218
112mast cell activation (GO:0045576)3.06748383
113negative regulation of leukocyte apoptotic process (GO:2000107)3.06691999
114Arp2/3 complex-mediated actin nucleation (GO:0034314)3.06012886
115negative regulation of gene expression, epigenetic (GO:0045814)3.05595746
116B cell differentiation (GO:0030183)3.05141113
117positive regulation of neutrophil migration (GO:1902624)3.03335340
118positive regulation of neutrophil chemotaxis (GO:0090023)3.03335340
119lymphocyte proliferation (GO:0046651)3.02127538
120regulation of thymocyte apoptotic process (GO:0070243)3.01394095
121antigen receptor-mediated signaling pathway (GO:0050851)3.01324671
122regulation of chromatin silencing (GO:0031935)3.01274783
123positive regulation of macrophage cytokine production (GO:0060907)3.00581849
124negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.00293992
125negative regulation of cell killing (GO:0031342)3.00293992
126translesion synthesis (GO:0019985)2.99753966
127negative regulation of RNA splicing (GO:0033119)2.99123944
128T cell lineage commitment (GO:0002360)2.97090844
129regulation of B cell activation (GO:0050864)2.96366500
130cellular response to interferon-gamma (GO:0071346)2.95855260
131translational elongation (GO:0006414)2.92610753
132adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.92417803
133mature B cell differentiation (GO:0002335)2.91462875
134T cell receptor signaling pathway (GO:0050852)2.91432439
135regulation of B cell apoptotic process (GO:0002902)2.91257097
136leukocyte homeostasis (GO:0001776)2.91057236
137germ cell migration (GO:0008354)2.90072675
138B cell homeostasis (GO:0001782)2.88962317
139alternative mRNA splicing, via spliceosome (GO:0000380)2.88002187
140negative regulation of T-helper cell differentiation (GO:0045623)2.86960247
141negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.86960247
142positive regulation of histone H3-K4 methylation (GO:0051571)2.86191722
143defense response to protozoan (GO:0042832)2.85405665
144regulation of neutrophil migration (GO:1902622)2.84419080
145regulation of neutrophil chemotaxis (GO:0090022)2.84419080
146adaptive immune response (GO:0002250)2.83659064
147B cell activation (GO:0042113)2.82816322
148chromatin silencing (GO:0006342)2.82370170
149positive regulation of protein deacetylation (GO:0090312)2.82097955
150positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.80377915
151chromatin assembly (GO:0031497)2.79530530
152cellular extravasation (GO:0045123)2.78873653
153regulation of B cell receptor signaling pathway (GO:0050855)2.78829382
154ribosomal small subunit biogenesis (GO:0042274)2.78588836
155modulation by host of symbiont transcription (GO:0052472)2.76978267
156modulation by host of viral transcription (GO:0043921)2.76978267
157negative regulation of T cell differentiation (GO:0045581)2.76514443
158production of molecular mediator involved in inflammatory response (GO:0002532)2.76104998
159nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.75910841
160mononuclear cell proliferation (GO:0032943)2.75589853
161cellular response to ethanol (GO:0071361)2.75020343
162regulation of extracellular matrix disassembly (GO:0010715)2.74849516
163negative regulation of B cell proliferation (GO:0030889)2.74612298
164lymph vessel development (GO:0001945)2.73686712
165regulation of granulocyte differentiation (GO:0030852)2.73594244
166protein complex disassembly (GO:0043241)2.73047986
167positive regulation of interferon-alpha production (GO:0032727)2.72698603
168DNA synthesis involved in DNA repair (GO:0000731)2.72521517
169regulation of interferon-alpha production (GO:0032647)2.71435930
170negative regulation of telomere maintenance (GO:0032205)2.71173174

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.99046000
2BP1_19119308_ChIP-ChIP_Hs578T_Human6.24024616
3FOXM1_23109430_ChIP-Seq_U2OS_Human5.52729704
4MYC_22102868_ChIP-Seq_BL_Human4.69533461
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.61041311
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.45398686
7VDR_21846776_ChIP-Seq_THP-1_Human3.26182671
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.14129698
9SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.12149745
10IRF8_22096565_ChIP-ChIP_GC-B_Human3.02254369
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.90182385
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.71358572
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.61951544
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.45878223
15E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.31603442
16MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.24238424
17CIITA_25753668_ChIP-Seq_RAJI_Human2.18630885
18UTX_26944678_Chip-Seq_JUKART_Human2.12507329
19SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.11349504
20SCL_19346495_ChIP-Seq_HPC-7_Human2.05311893
21MYB_26560356_Chip-Seq_TH2_Human1.97516320
22MAF_26560356_Chip-Seq_TH1_Human1.96910991
23VDR_24763502_ChIP-Seq_THP-1_Human1.96454885
24STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.96373592
25SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.95358464
26MYB_26560356_Chip-Seq_TH1_Human1.87984843
27TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.81421012
28TCF7_22412390_ChIP-Seq_EML_Mouse1.80281201
29NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.79612724
30IRF8_21731497_ChIP-ChIP_J774_Mouse1.71964667
31RUNX_20019798_ChIP-Seq_JUKART_Human1.69604259
32KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.69552356
33E2F1_21310950_ChIP-Seq_MCF-7_Human1.69388040
34FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.68095012
35TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.65223708
36FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.64925823
37TP63_19390658_ChIP-ChIP_HaCaT_Human1.58828016
38BCL6_27268052_Chip-Seq_Bcells_Human1.55917670
39ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.54951671
40SPI1_23547873_ChIP-Seq_NB4_Human1.53238497
41PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.51254654
42MYC_18555785_ChIP-Seq_MESCs_Mouse1.49461249
43KDM2B_26808549_Chip-Seq_SUP-B15_Human1.48675792
44KDM2B_26808549_Chip-Seq_DND41_Human1.47348526
45FOXP3_21729870_ChIP-Seq_TREG_Human1.46492069
46MYC_19079543_ChIP-ChIP_MESCs_Mouse1.45274215
47LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.45195894
48HOXB4_20404135_ChIP-ChIP_EML_Mouse1.43778309
49VDR_23849224_ChIP-Seq_CD4+_Human1.42562984
50BCOR_27268052_Chip-Seq_Bcells_Human1.41347484
51ELF1_20517297_ChIP-Seq_JURKAT_Human1.40498631
52VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.39042076
53MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.36271346
54FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.35003307
55LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.33397148
56BRD4_27068464_Chip-Seq_AML-cells_Mouse1.33075266
57MYC_19030024_ChIP-ChIP_MESCs_Mouse1.32802713
58IRF8_27001747_Chip-Seq_BMDM_Mouse1.32106123
59BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.31766699
60NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.31384516
61ELF1_17652178_ChIP-ChIP_JURKAT_Human1.30931241
62XRN2_22483619_ChIP-Seq_HELA_Human1.30868097
63ERG_20887958_ChIP-Seq_HPC-7_Mouse1.30668692
64SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.29989321
65RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.28742149
66GATA3_26560356_Chip-Seq_TH2_Human1.27941239
67MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.27487533
68RUNX1_22412390_ChIP-Seq_EML_Mouse1.27486136
69MAF_26560356_Chip-Seq_TH2_Human1.26758704
70NELFA_20434984_ChIP-Seq_ESCs_Mouse1.24651764
71AR_21909140_ChIP-Seq_LNCAP_Human1.23721692
72GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.23192139
73SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.21708522
74SPI1_23127762_ChIP-Seq_K562_Human1.21252681
75P300_27268052_Chip-Seq_Bcells_Human1.20541199
76GATA2_22383799_ChIP-Seq_G1ME_Mouse1.20133969
77SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.19566431
78KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.19401726
79ELK3_25401928_ChIP-Seq_HUVEC_Human1.19384680
80RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.18689686
81THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.17145036
82EST1_17652178_ChIP-ChIP_JURKAT_Human1.16460679
83KDM5A_27292631_Chip-Seq_BREAST_Human1.16045270
84GATA1_22025678_ChIP-Seq_K562_Human1.13004034
85GATA1_22383799_ChIP-Seq_G1ME_Mouse1.12546469
86MYB_21317192_ChIP-Seq_ERMYB_Mouse1.12249308
87YY1_21170310_ChIP-Seq_MESCs_Mouse1.12046332
88NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.11798153
89TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.11592228
90MYC_18358816_ChIP-ChIP_MESCs_Mouse1.11570924
91NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.10528015
92STAT4_19710469_ChIP-ChIP_TH1__Mouse1.10146604
93ETS1_20019798_ChIP-Seq_JURKAT_Human1.06311465
94IKZF1_21737484_ChIP-ChIP_HCT116_Human1.05745868
95CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02125673
96VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.01998453
97GATA3_27048872_Chip-Seq_THYMUS_Human1.01551742
98PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01542064
99CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.00269658
100NOTCH1_21737748_ChIP-Seq_TLL_Human0.98580910
101PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98242342
102LXR_22292898_ChIP-Seq_THP-1_Human0.97532750
103GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.96188761
104CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95100836
105PU.1_20513432_ChIP-Seq_Bcells_Mouse0.94442723
106EGR1_23403033_ChIP-Seq_LIVER_Mouse0.93861044
107* ETS1_21867929_ChIP-Seq_TH2_Mouse0.93601819
108CREB1_15753290_ChIP-ChIP_HEK293T_Human0.93168737
109E2F1_20622854_ChIP-Seq_HELA_Human0.91587196
110PADI4_21655091_ChIP-ChIP_MCF-7_Human0.91447851
111SMRT_27268052_Chip-Seq_Bcells_Human0.91109210
112E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.91070063
113P68_20966046_ChIP-Seq_HELA_Human0.90206797
114NCOR1_26117541_ChIP-Seq_K562_Human0.89318066
115EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.87895424
116KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.87674155
117SPI1_20517297_ChIP-Seq_HL60_Human0.87630708
118CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.87519996
119RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.87032094
120SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.86695815
121STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.86482548
122SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.86237971
123FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86180036
124GATA1_19941826_ChIP-Seq_K562_Human0.85959436
125MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.85109289
126ELK1_19687146_ChIP-ChIP_HELA_Human0.84786170
127GATA1_19941827_ChIP-Seq_MEL_Mouse0.84662338
128DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.84639248
129SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84593767
130IRF1_19129219_ChIP-ChIP_H3396_Human0.83671554
131CTCF_26484167_Chip-Seq_Bcells_Mouse0.83658659
132GABP_17652178_ChIP-ChIP_JURKAT_Human0.83022626
133HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.82459753
134SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.81976647
135CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.81159849
136CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.80651290
137POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.80422067
138CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.80398430
139MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.80187849

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002138_abnormal_hepatobiliary_system5.49438890
2MP0001800_abnormal_humoral_immune3.98290012
3MP0000685_abnormal_immune_system3.50738036
4MP0010094_abnormal_chromosome_stability3.28702342
5MP0002396_abnormal_hematopoietic_system3.15911033
6MP0005387_immune_system_phenotype3.03028168
7MP0001790_abnormal_immune_system3.03028168
8MP0001835_abnormal_antigen_presentation3.03011587
9MP0009278_abnormal_bone_marrow3.01596798
10MP0002452_abnormal_antigen_presenting2.99753850
11MP0002398_abnormal_bone_marrow2.98041262
12MP0004808_abnormal_hematopoietic_stem2.75049862
13MP0000689_abnormal_spleen_morphology2.74960507
14MP0006054_spinal_hemorrhage2.70657692
15MP0003693_abnormal_embryo_hatching2.60813707
16MP0003303_peritoneal_inflammation2.58607299
17MP0003111_abnormal_nucleus_morphology2.48647820
18MP0002722_abnormal_immune_system2.48228896
19MP0000716_abnormal_immune_system2.47807498
20MP0002420_abnormal_adaptive_immunity2.47101764
21MP0002723_abnormal_immune_serum2.44879036
22MP0001819_abnormal_immune_cell2.41871547
23MP0003077_abnormal_cell_cycle2.36583054
24MP0000703_abnormal_thymus_morphology2.33573252
25MP0005671_abnormal_response_to2.29225129
26MP0008057_abnormal_DNA_replication2.24628681
27MP0002166_altered_tumor_susceptibility2.16764257
28MP0003183_abnormal_peptide_metabolism2.16631672
29MP0002429_abnormal_blood_cell2.10890341
30MP0004957_abnormal_blastocyst_morpholog2.04111312
31MP0005000_abnormal_immune_tolerance1.99841616
32MP0009785_altered_susceptibility_to1.96388590
33MP0001545_abnormal_hematopoietic_system1.94213584
34MP0005397_hematopoietic_system_phenotyp1.94213584
35MP0003436_decreased_susceptibility_to1.91385427
36MP0002019_abnormal_tumor_incidence1.86091511
37MP0003763_abnormal_thymus_physiology1.79950611
38MP0005451_abnormal_body_composition1.77885380
39MP0010307_abnormal_tumor_latency1.75834765
40MP0003300_gastrointestinal_ulcer1.74422383
41MP0004947_skin_inflammation1.64253121
42MP0000490_abnormal_crypts_of1.60149381
43MP0010352_gastrointestinal_tract_polyps1.51211188
44MP0001879_abnormal_lymphatic_vessel1.50738893
45MP0005025_abnormal_response_to1.50368154
46MP0005645_abnormal_hypothalamus_physiol1.49546451
47MP0010155_abnormal_intestine_physiology1.49245652
48MP0002405_respiratory_system_inflammati1.39102625
49MP0002006_tumorigenesis1.38645296
50MP0000350_abnormal_cell_proliferation1.35613767
51MP0008058_abnormal_DNA_repair1.33059803
52MP0005075_abnormal_melanosome_morpholog1.30718905
53MP0003786_premature_aging1.30041819
54MP0001730_embryonic_growth_arrest1.28815319
55MP0003724_increased_susceptibility_to1.28719884
56MP0001986_abnormal_taste_sensitivity1.28109286
57MP0008007_abnormal_cellular_replicative1.27996283
58MP0000015_abnormal_ear_pigmentation1.24435350
59MP0005464_abnormal_platelet_physiology1.22234079
60MP0009333_abnormal_splenocyte_physiolog1.17786378
61MP0002653_abnormal_ependyma_morphology1.17471893
62MP0010234_abnormal_vibrissa_follicle1.12821509
63MP0002419_abnormal_innate_immunity1.11669471
64MP0008877_abnormal_DNA_methylation1.11280981
65MP0001845_abnormal_inflammatory_respons1.09027807
66MP0005076_abnormal_cell_differentiation1.06958601
67MP0000465_gastrointestinal_hemorrhage1.05349727
68MP0003866_abnormal_defecation1.04584671
69MP0000313_abnormal_cell_death1.03892924
70MP0005220_abnormal_exocrine_pancreas1.03077068
71MP0005310_abnormal_salivary_gland0.99931133
72MP0002933_joint_inflammation0.98617552
73MP0001873_stomach_inflammation0.98289674
74MP0008995_early_reproductive_senescence0.87319117
75MP0004233_abnormal_muscle_weight0.85913275
76MP0003191_abnormal_cellular_cholesterol0.85054726
77MP0003806_abnormal_nucleotide_metabolis0.83160859
78MP0001661_extended_life_span0.82100425
79MP0003646_muscle_fatigue0.81767730
80MP0002080_prenatal_lethality0.80166109
81MP0002009_preneoplasia0.79833416
82MP0001919_abnormal_reproductive_system0.79447181
83MP0002148_abnormal_hypersensitivity_rea0.79059148
84MP0000249_abnormal_blood_vessel0.78942626
85MP0009931_abnormal_skin_appearance0.77560443
86MP0009764_decreased_sensitivity_to0.76716882
87MP0001853_heart_inflammation0.76479451
88MP0000613_abnormal_salivary_gland0.76060344
89MP0001915_intracranial_hemorrhage0.75282492
90MP0002095_abnormal_skin_pigmentation0.75270401
91MP0005501_abnormal_skin_physiology0.74935741
92MP0003984_embryonic_growth_retardation0.74161903
93MP0001672_abnormal_embryogenesis/_devel0.72631646
94MP0005380_embryogenesis_phenotype0.72631646
95MP0003172_abnormal_lysosome_physiology0.70286784
96MP0001533_abnormal_skeleton_physiology0.69775953
97MP0005621_abnormal_cell_physiology0.68986765
98MP0002088_abnormal_embryonic_growth/wei0.68840452
99MP0003943_abnormal_hepatobiliary_system0.68338901
100MP0000013_abnormal_adipose_tissue0.68222686
101MP0009780_abnormal_chondrocyte_physiolo0.65816020
102MP0004197_abnormal_fetal_growth/weight/0.65195028
103MP0001697_abnormal_embryo_size0.65162856
104MP0005381_digestive/alimentary_phenotyp0.63944795
105MP0000477_abnormal_intestine_morphology0.63380650
106MP0001727_abnormal_embryo_implantation0.63157532
107MP0002136_abnormal_kidney_physiology0.62554663
108MP0003252_abnormal_bile_duct0.62310743
109MP0002083_premature_death0.62161223
110MP0008961_abnormal_basal_metabolism0.61258141
111MP0000604_amyloidosis0.60992408
112MP0001663_abnormal_digestive_system0.59882304
113MP0002132_abnormal_respiratory_system0.59798976
114MP0004381_abnormal_hair_follicle0.59580263
115MP0003656_abnormal_erythrocyte_physiolo0.59444033
116MP0002970_abnormal_white_adipose0.58037940
117MP0005166_decreased_susceptibility_to0.57877014
118MP0009643_abnormal_urine_homeostasis0.57174311
119MP0008872_abnormal_physiological_respon0.56832248
120MP0002060_abnormal_skin_morphology0.56296413
121MP0008874_decreased_physiological_sensi0.54609456
122MP0002876_abnormal_thyroid_physiology0.54394391
123MP0008469_abnormal_protein_level0.52590212
124MP0002086_abnormal_extraembryonic_tissu0.52562994
125MP0009840_abnormal_foam_cell0.51759146
126MP0005584_abnormal_enzyme/coenzyme_acti0.48529918
127MP0005360_urolithiasis0.46945170
128MP0002928_abnormal_bile_duct0.45751270
129MP0000372_irregular_coat_pigmentation0.44521064
130MP0001851_eye_inflammation0.39420878
131MP0006036_abnormal_mitochondrial_physio0.39247911
132MP0005085_abnormal_gallbladder_physiolo0.38301036
133MP0005266_abnormal_metabolism0.36824037
134MP0001764_abnormal_homeostasis0.35546838
135MP0000470_abnormal_stomach_morphology0.34560829

Predicted human phenotypes

RankGene SetZ-score
1Cellulitis (HP:0100658)8.28556985
2Papilloma (HP:0012740)7.88965695
3Verrucae (HP:0200043)7.88965695
4Abnormality of B cell number (HP:0010975)6.74346652
5B lymphocytopenia (HP:0010976)6.74346652
6Thyroiditis (HP:0100646)6.68536347
7Small epiphyses (HP:0010585)5.59376340
8Recurrent bronchitis (HP:0002837)5.39396121
9Panhypogammaglobulinemia (HP:0003139)5.24005228
10Meningitis (HP:0001287)4.95269320
11Osteomyelitis (HP:0002754)4.81414753
12Recurrent viral infections (HP:0004429)4.67168542
13Severe combined immunodeficiency (HP:0004430)4.58361181
14Sepsis (HP:0100806)4.41420992
15Chronic sinusitis (HP:0011109)4.30021939
16Combined immunodeficiency (HP:0005387)4.23957266
17Hypoplasia of the thymus (HP:0000778)4.23682929
18Vertebral arch anomaly (HP:0008438)4.18345408
19Recurrent pneumonia (HP:0006532)4.13483925
20Abnormality of the intervertebral disk (HP:0005108)3.94392706
21Hypoplasia of the capital femoral epiphysis (HP:0003090)3.89548233
22Recurrent sinusitis (HP:0011108)3.85081853
23Colitis (HP:0002583)3.76721854
24Eczematoid dermatitis (HP:0000976)3.63172533
25IgM deficiency (HP:0002850)3.63155348
26Recurrent lower respiratory tract infections (HP:0002783)3.59828148
27Abnormality of the prostate (HP:0008775)3.52428204
28Gastrointestinal stroma tumor (HP:0100723)3.50849747
29Mediastinal lymphadenopathy (HP:0100721)3.50752249
30Flattened epiphyses (HP:0003071)3.42184857
31Gastrointestinal inflammation (HP:0004386)3.38618289
32IgG deficiency (HP:0004315)3.32822919
33Recurrent otitis media (HP:0000403)3.32509829
34T lymphocytopenia (HP:0005403)3.31762745
35Inflammation of the large intestine (HP:0002037)3.24972182
36Bronchitis (HP:0012387)3.19376559
37Recurrent bacterial skin infections (HP:0005406)3.19138962
38Abnormality of T cell number (HP:0011839)3.13534201
39Mitral stenosis (HP:0001718)3.09418217
40Chronic obstructive pulmonary disease (HP:0006510)3.09210519
41Obstructive lung disease (HP:0006536)3.09210519
42Absent epiphyses (HP:0010577)3.08911450
43Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)3.08911450
44Ulnar bowing (HP:0003031)3.04671051
45Hypoproteinemia (HP:0003075)3.03719145
46Skin rash (HP:0000988)3.01225008
47Prostate neoplasm (HP:0100787)2.96392027
48Eosinophilia (HP:0001880)2.95810125
49Elevated erythrocyte sedimentation rate (HP:0003565)2.95143688
50Recurrent fungal infections (HP:0002841)2.94300998
51Lymphopenia (HP:0001888)2.91111342
52Abnormality of cells of the lymphoid lineage (HP:0012140)2.86499778
53Recurrent abscess formation (HP:0002722)2.83298861
54Chronic otitis media (HP:0000389)2.71671071
55Abnormality of T cells (HP:0002843)2.64013734
56Irregular vertebral endplates (HP:0003301)2.55931721
57Arthropathy (HP:0003040)2.55585020
58Recurrent gram-negative bacterial infections (HP:0005420)2.53199610
59Abnormality of the fingertips (HP:0001211)2.52802349
60Granulocytopenia (HP:0001913)2.49357616
61Cutaneous melanoma (HP:0012056)2.48122986
62Aplasia/Hypoplasia of the thymus (HP:0010515)2.43164581
63Increased IgE level (HP:0003212)2.41073879
64Abnormality of eosinophils (HP:0001879)2.40594376
65Petechiae (HP:0000967)2.36586211
66Lymphoma (HP:0002665)2.33490742
67Dehydration (HP:0001944)2.28954445
68Abnormality of male internal genitalia (HP:0000022)2.24205269
69Abnormality of the thymus (HP:0000777)2.22019808
70Abnormal delayed hypersensitivity skin test (HP:0002963)2.21653361
71Abnormality of the pleura (HP:0002103)2.21638739
72Autoimmune thrombocytopenia (HP:0001973)2.21509582
73Stomach cancer (HP:0012126)2.17050841
74Limited elbow extension (HP:0001377)2.16406606
75Chronic diarrhea (HP:0002028)2.15404633
76Acute lymphatic leukemia (HP:0006721)2.12772338
77Vertebral clefting (HP:0008428)2.12213733
78Pulmonary infiltrates (HP:0002113)2.11927802
79Patellar aplasia (HP:0006443)2.11817118
80External ear malformation (HP:0008572)2.11572975
81Pulmonary fibrosis (HP:0002206)2.11490348
82Cutis marmorata (HP:0000965)2.11067534
83Abnormality of macrophages (HP:0004311)2.11048993
84Recurrent skin infections (HP:0001581)2.10142679
85Hemorrhage of the eye (HP:0011885)2.10142011
86Neutropenia (HP:0001875)2.09519684
87Dry hair (HP:0011359)2.06416763
88Emphysema (HP:0002097)2.05113725
89Abnormality of T cell physiology (HP:0011840)2.04287358
90Barrel-shaped chest (HP:0001552)2.02605951
91Long eyelashes (HP:0000527)2.02319930
92Volvulus (HP:0002580)2.01871749
93Urticaria (HP:0001025)2.01183376
94Agammaglobulinemia (HP:0004432)10.2914398
95Skin ulcer (HP:0200042)1.99717499
96Encephalitis (HP:0002383)1.98829829
97Autoimmune hemolytic anemia (HP:0001890)1.98444082
98Reticulocytopenia (HP:0001896)1.97486438
99IgA deficiency (HP:0002720)1.97408385
100Erythroderma (HP:0001019)1.96285116
101Pustule (HP:0200039)1.94038658
102Aplasia/Hypoplasia of the patella (HP:0006498)1.92860775
103Lower limb hyperreflexia (HP:0002395)1.90831979
104Vasculitis (HP:0002633)1.87890050
105Chest pain (HP:0100749)1.86526875
106Increased IgM level (HP:0003496)1.86526458
107Abnormality of the tricuspid valve (HP:0001702)1.85359836
108Abnormality of the vertebral endplates (HP:0005106)1.83571096
109Abnormality of small intestinal villus morphology (HP:0011472)1.80470429
110Villous atrophy (HP:0011473)1.80470429
111Thrombocytosis (HP:0001894)1.79584203
112Aortic regurgitation (HP:0001659)1.74247769
113Ridged nail (HP:0001807)1.72787569
114Systemic lupus erythematosus (HP:0002725)1.71941186
115Bowing of the arm (HP:0006488)1.71457763
116Bowed forearm bones (HP:0003956)1.71457763
117Purpura (HP:0000979)1.70185903
118Restrictive lung disease (HP:0002091)1.69899320
119Microvesicular hepatic steatosis (HP:0001414)1.67999553
120Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.67834284
121Leukocytosis (HP:0001974)1.66751991
122Gastrointestinal infarctions (HP:0005244)1.62881827
123Hypertensive crisis (HP:0100735)1.61886622
124Hemoptysis (HP:0002105)1.60882631
125Interstitial pulmonary disease (HP:0006530)1.58987222
126Viral hepatitis (HP:0006562)1.58952489
127Basal cell carcinoma (HP:0002671)1.56413202
128Leukopenia (HP:0001882)1.56401155
129Stomatitis (HP:0010280)1.56152524
130Spontaneous hematomas (HP:0007420)1.53435719
131Aqueductal stenosis (HP:0002410)1.52763188
132Arthralgia (HP:0002829)1.48883968
133Squamous cell carcinoma (HP:0002860)1.48292076
134Abnormality of the pancreatic islet cells (HP:0006476)1.48126047
135Abnormality of endocrine pancreas physiology (HP:0012093)1.48126047
136Abnormality of chromosome segregation (HP:0002916)1.48008190
137Recurrent cutaneous fungal infections (HP:0011370)1.47182044
138Chronic mucocutaneous candidiasis (HP:0002728)1.47182044
139Carpal bone hypoplasia (HP:0001498)1.45798039
140Fatigue (HP:0012378)1.45643700
141Hematochezia (HP:0002573)1.44978281

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K108.98429924
2EEF2K4.37752106
3ERN13.30378366
4GRK63.24840057
5MAP4K12.92588071
6KIT2.69028626
7IRAK42.66054882
8NEK22.42613463
9STK42.12279208
10SYK2.00304247
11MAP3K131.96332324
12TLK11.90772680
13STK101.90688133
14BTK1.85504568
15SIK21.84886055
16BUB11.83778206
17CDK41.74415240
18JAK31.71290565
19RPS6KB21.69443721
20PKN21.68123042
21BMPR21.67191242
22CLK11.55447920
23CSF1R1.52902031
24KDR1.51081786
25BLK1.50877447
26LRRK21.50583488
27RIPK41.48634997
28CDC71.46932987
29PDK21.41131493
30TRIB31.40843752
31MAP3K141.33830567
32MAP3K111.30756986
33FRK1.29700943
34MAPK111.27443081
35EIF2AK31.27090150
36BMPR1B1.25792795
37FGFR21.24522345
38CDK121.21517768
39CDK81.20848158
40PIM11.20316808
41LYN1.17017861
42FES1.16035012
43MAPK121.13410356
44MAPK41.11648314
45IKBKB1.10189335
46DYRK31.06259453
47DYRK1B1.06050867
48SMG11.01721697
49VRK20.99472455
50WEE10.97864349
51NLK0.89777763
52MAP3K80.88007728
53SCYL20.85934519
54CDK90.85272734
55TESK20.83086481
56HCK0.80813387
57MELK0.80608971
58PDK10.78362646
59PRKCI0.76293071
60MAP2K30.76008389
61SIK30.75234577
62CCNB10.71305936
63CDK60.70811849
64TYK20.70323472
65TNK20.70189519
66PRPF4B0.69660981
67DAPK10.69467058
68MAP2K20.68264687
69BRSK10.67901599
70AURKB0.66591138
71RPS6KA40.65719759
72HIPK20.64789475
73BCKDK0.64474543
74MST40.62523935
75VRK10.62331530
76PASK0.62070604
77MAPKAPK30.61771189
78LCK0.60994053
79FGFR30.60551239
80MAP3K70.60288003
81MARK30.58508203
82ZAP700.58078471
83MAPK130.57885149
84RPS6KB10.57483468
85FYN0.56034658
86MAP3K30.55148162
87CHEK10.54531891
88PRKCQ0.53420363
89ATR0.53142402
90MAPK70.52967142
91PIK3CG0.52256000
92ABL10.49578885
93TAOK10.49292655
94STK30.48483064
95TTK0.47134306
96CHEK20.46764000
97ZAK0.46118783
98ITK0.46039079
99PRKD10.45114146
100EIF2AK10.45086081
101BRAF0.44309945
102PLK20.42388343
103MAPKAPK20.42174026
104CSNK1D0.42151637
105BRD40.41319058
106PDPK10.40242676
107CDK20.39855895
108CDK190.39481045
109CSK0.38853247
110TGFBR10.37710632
111TEC0.37543350
112PLK10.36100761
113PRKCH0.36013631
114WNK10.35887848
115IKBKE0.35342888
116GRK10.35175280
117PRKD20.34805285
118TBK10.33895655
119MARK20.33451947
120STK240.32012211
121JAK10.31594372
122ALK0.29695126
123AURKA0.29541633
124RPS6KA50.29521438
125RPS6KL10.28961035
126RPS6KC10.28961035
127RPS6KA60.28765822
128SRPK10.27621504
129ARAF0.27314722
130CDK140.27022335
131MAP2K10.26758652
132MAP3K10.26472344
133DAPK30.26180863
134ACVR1B0.26062878
135CDK70.24510722
136CDK11A0.23284471
137CSNK2A20.22190334
138CDK150.22115745
139INSR0.20031321
140TAOK30.19125457
141CDK30.18627822
142JAK20.18066675
143IRAK20.17848932
144CHUK0.17076369

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053406.71597129
2Asthma_Homo sapiens_hsa053105.10319145
3Allograft rejection_Homo sapiens_hsa053304.73090499
4B cell receptor signaling pathway_Homo sapiens_hsa046624.68448956
5Autoimmune thyroid disease_Homo sapiens_hsa053204.43415304
6Graft-versus-host disease_Homo sapiens_hsa053324.28576796
7Non-homologous end-joining_Homo sapiens_hsa034503.78952092
8Type I diabetes mellitus_Homo sapiens_hsa049403.68275200
9DNA replication_Homo sapiens_hsa030303.42831695
10Base excision repair_Homo sapiens_hsa034103.17063695
11Mismatch repair_Homo sapiens_hsa034303.04114765
12Staphylococcus aureus infection_Homo sapiens_hsa051502.83054937
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.76040781
14Viral myocarditis_Homo sapiens_hsa054162.65829944
15Systemic lupus erythematosus_Homo sapiens_hsa053222.63436147
16Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.14275911
17Cell cycle_Homo sapiens_hsa041102.09295255
18Ribosome_Homo sapiens_hsa030102.05920997
19Spliceosome_Homo sapiens_hsa030401.87714301
20Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.79332427
21Homologous recombination_Homo sapiens_hsa034401.78681228
22NF-kappa B signaling pathway_Homo sapiens_hsa040641.78616287
23Intestinal immune network for IgA production_Homo sapiens_hsa046721.78205657
24Non-small cell lung cancer_Homo sapiens_hsa052231.66235975
25Viral carcinogenesis_Homo sapiens_hsa052031.59934781
26Alcoholism_Homo sapiens_hsa050341.54375947
27Nucleotide excision repair_Homo sapiens_hsa034201.46429156
28Rheumatoid arthritis_Homo sapiens_hsa053231.44967696
29Chronic myeloid leukemia_Homo sapiens_hsa052201.42153382
30Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.41478363
31Epstein-Barr virus infection_Homo sapiens_hsa051691.27260955
32RNA transport_Homo sapiens_hsa030131.25773859
33Osteoclast differentiation_Homo sapiens_hsa043801.25458064
34Transcriptional misregulation in cancer_Homo sapiens_hsa052021.25342903
35p53 signaling pathway_Homo sapiens_hsa041151.22224860
36Antigen processing and presentation_Homo sapiens_hsa046121.16355714
37Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.15082419
38Glioma_Homo sapiens_hsa052141.13024842
39mRNA surveillance pathway_Homo sapiens_hsa030151.12439931
40Pyrimidine metabolism_Homo sapiens_hsa002401.08508300
41Pancreatic cancer_Homo sapiens_hsa052121.01039363
42Herpes simplex infection_Homo sapiens_hsa051680.99137508
43HTLV-I infection_Homo sapiens_hsa051660.97968059
44Pentose phosphate pathway_Homo sapiens_hsa000300.96578118
45Hematopoietic cell lineage_Homo sapiens_hsa046400.94416517
46Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.94052774
47FoxO signaling pathway_Homo sapiens_hsa040680.93972252
48Measles_Homo sapiens_hsa051620.93109493
49Hepatitis B_Homo sapiens_hsa051610.92311284
50Fanconi anemia pathway_Homo sapiens_hsa034600.92246274
51mTOR signaling pathway_Homo sapiens_hsa041500.88851236
52Acute myeloid leukemia_Homo sapiens_hsa052210.87956361
53MicroRNAs in cancer_Homo sapiens_hsa052060.85956195
54Phosphatidylinositol signaling system_Homo sapiens_hsa040700.85455367
55Leukocyte transendothelial migration_Homo sapiens_hsa046700.85218699
56Platelet activation_Homo sapiens_hsa046110.82496581
57Small cell lung cancer_Homo sapiens_hsa052220.81958479
58Sulfur metabolism_Homo sapiens_hsa009200.81216286
59SNARE interactions in vesicular transport_Homo sapiens_hsa041300.80647379
60Phagosome_Homo sapiens_hsa041450.79930227
61Leishmaniasis_Homo sapiens_hsa051400.78446185
62One carbon pool by folate_Homo sapiens_hsa006700.77569733
63Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.77247929
64Apoptosis_Homo sapiens_hsa042100.76827778
65Colorectal cancer_Homo sapiens_hsa052100.76393422
66Shigellosis_Homo sapiens_hsa051310.76350038
67Inositol phosphate metabolism_Homo sapiens_hsa005620.74867578
68alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.71894226
69Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.67827194
70Neurotrophin signaling pathway_Homo sapiens_hsa047220.65810742
71Chemokine signaling pathway_Homo sapiens_hsa040620.64347141
72Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.63145879
73Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.62026046
74Olfactory transduction_Homo sapiens_hsa047400.61987952
75Proteasome_Homo sapiens_hsa030500.61961841
76T cell receptor signaling pathway_Homo sapiens_hsa046600.61514246
77Prostate cancer_Homo sapiens_hsa052150.60804850
78VEGF signaling pathway_Homo sapiens_hsa043700.60731425
79RNA polymerase_Homo sapiens_hsa030200.60105466
80Tuberculosis_Homo sapiens_hsa051520.57137304
81Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55833815
82Sulfur relay system_Homo sapiens_hsa041220.54505498
83RNA degradation_Homo sapiens_hsa030180.52149127
84AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.51837631
85Oocyte meiosis_Homo sapiens_hsa041140.51317413
86Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51298722
87Insulin resistance_Homo sapiens_hsa049310.49438282
88Renin-angiotensin system_Homo sapiens_hsa046140.47628790
89Purine metabolism_Homo sapiens_hsa002300.45990126
90Influenza A_Homo sapiens_hsa051640.45678204
91Jak-STAT signaling pathway_Homo sapiens_hsa046300.44880817
92Carbohydrate digestion and absorption_Homo sapiens_hsa049730.44662926
93HIF-1 signaling pathway_Homo sapiens_hsa040660.44517132
94Toxoplasmosis_Homo sapiens_hsa051450.42914285
95Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.40190190
96African trypanosomiasis_Homo sapiens_hsa051430.39554210
97Toll-like receptor signaling pathway_Homo sapiens_hsa046200.35604889
98Lysine degradation_Homo sapiens_hsa003100.34524988
99Choline metabolism in cancer_Homo sapiens_hsa052310.33385163
100Endometrial cancer_Homo sapiens_hsa052130.32750283
101Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.32461965
102Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.31241622
103Phospholipase D signaling pathway_Homo sapiens_hsa040720.30887455
104Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.30298948
105Malaria_Homo sapiens_hsa051440.29160594
106Caffeine metabolism_Homo sapiens_hsa002320.29056604
107NOD-like receptor signaling pathway_Homo sapiens_hsa046210.27991343
108ErbB signaling pathway_Homo sapiens_hsa040120.25904285
109Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.25789521
110Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.25520853
111Selenocompound metabolism_Homo sapiens_hsa004500.25355289
112Drug metabolism - other enzymes_Homo sapiens_hsa009830.24538778
113Linoleic acid metabolism_Homo sapiens_hsa005910.24245140
114Renal cell carcinoma_Homo sapiens_hsa052110.24242797
115Endocytosis_Homo sapiens_hsa041440.24053395
116Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.21560438
117Legionellosis_Homo sapiens_hsa051340.20903005
118RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.20897183
119Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.20870706
120Arachidonic acid metabolism_Homo sapiens_hsa005900.20718965
121Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.20652325
122AMPK signaling pathway_Homo sapiens_hsa041520.20428157
123Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.19627106
124Hepatitis C_Homo sapiens_hsa051600.19112245
125Pertussis_Homo sapiens_hsa051330.16035797
126Ether lipid metabolism_Homo sapiens_hsa005650.13775538
127Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.13135176
128TNF signaling pathway_Homo sapiens_hsa046680.12132737
129Fat digestion and absorption_Homo sapiens_hsa049750.09990713
130Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.08091118
131Fructose and mannose metabolism_Homo sapiens_hsa000510.07508467
132Cyanoamino acid metabolism_Homo sapiens_hsa004600.06259259
133Glycerophospholipid metabolism_Homo sapiens_hsa005640.04804474
134Parkinsons disease_Homo sapiens_hsa050120.01591132
135Fatty acid metabolism_Homo sapiens_hsa01212-0.0683432
136Sphingolipid signaling pathway_Homo sapiens_hsa04071-0.0505508
137Prolactin signaling pathway_Homo sapiens_hsa04917-0.0426620
138Notch signaling pathway_Homo sapiens_hsa04330-0.0094130

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