VPS11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps11 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of autophagic vacuole assembly (GO:2000785)5.55187369
2COPI coating of Golgi vesicle (GO:0048205)5.54473702
3Golgi transport vesicle coating (GO:0048200)5.54473702
4regulation of vacuole organization (GO:0044088)4.85953659
5positive regulation of catecholamine secretion (GO:0033605)4.66620590
6synaptic vesicle maturation (GO:0016188)4.46389932
7macroautophagy (GO:0016236)4.26545416
8positive regulation of gamma-delta T cell activation (GO:0046645)4.04783696
9synaptic vesicle docking involved in exocytosis (GO:0016081)3.97534139
10retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.96147265
11regulation of short-term neuronal synaptic plasticity (GO:0048172)3.86639965
12regulation of phosphoprotein phosphatase activity (GO:0043666)3.85179460
13histone H3-K36 demethylation (GO:0070544)3.83195698
14positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.80504580
15sodium ion export (GO:0071436)3.70304871
16TOR signaling (GO:0031929)3.66086984
17NADH metabolic process (GO:0006734)3.60703889
18negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.57520214
19regulation of synaptic vesicle exocytosis (GO:2000300)3.52004573
20regulation of oxidative stress-induced neuron death (GO:1903203)3.48531173
21synaptic vesicle exocytosis (GO:0016079)3.45095085
22mannose metabolic process (GO:0006013)3.44729486
23potassium ion export (GO:0071435)3.41770826
24L-alpha-amino acid transmembrane transport (GO:1902475)3.38384660
25oxaloacetate metabolic process (GO:0006107)3.37994814
26positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.33631280
27locomotory exploration behavior (GO:0035641)3.32741047
28regulation of synaptic vesicle transport (GO:1902803)3.32469553
29regulation of NFAT protein import into nucleus (GO:0051532)3.29750789
30alanine transport (GO:0032328)3.29427631
31regulation of ARF protein signal transduction (GO:0032012)3.28265920
32motile cilium assembly (GO:0044458)3.28063300
33activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.27670907
34negative regulation of macroautophagy (GO:0016242)3.24098119
35regulation of gamma-delta T cell differentiation (GO:0045586)3.18737667
36regulation of gamma-delta T cell activation (GO:0046643)3.16604712
37proline transport (GO:0015824)3.15420333
38coenzyme catabolic process (GO:0009109)3.13893451
39thymic T cell selection (GO:0045061)3.13868737
40antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.10089463
41antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.10089463
42cerebellar Purkinje cell layer development (GO:0021680)3.09203457
43positive regulation of nuclease activity (GO:0032075)3.08027378
44vesicle coating (GO:0006901)3.07688043
45regulation of oxidative phosphorylation (GO:0002082)3.05643575
46activation of protein kinase A activity (GO:0034199)3.00286868
47positive thymic T cell selection (GO:0045059)3.00003051
48neurotransmitter secretion (GO:0007269)2.99892766
49glutamate secretion (GO:0014047)2.97986285
50regulation of mast cell degranulation (GO:0043304)2.97022940
51antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.93865500
52transferrin transport (GO:0033572)2.93355028
53mast cell degranulation (GO:0043303)2.93007549
54mast cell activation involved in immune response (GO:0002279)2.93007549
55negative regulation of erythrocyte differentiation (GO:0045647)2.91916409
56tricarboxylic acid metabolic process (GO:0072350)2.91842885
57positive regulation of synapse maturation (GO:0090129)2.91137157
58T cell selection (GO:0045058)2.90724075
59regulation of myeloid leukocyte mediated immunity (GO:0002886)2.90523131
60cellular potassium ion homeostasis (GO:0030007)2.90363383
61cellular response to zinc ion (GO:0071294)2.90001728
62activation of protein kinase B activity (GO:0032148)2.87109705
63negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.86274399
64negative regulation of cell killing (GO:0031342)2.86274399
65negative regulation of cell size (GO:0045792)2.83667972
66antigen processing and presentation of endogenous antigen (GO:0019883)2.83509184
67negative regulation of bone resorption (GO:0045779)2.82486726
68mast cell activation (GO:0045576)2.81170080
69diacylglycerol metabolic process (GO:0046339)2.80304556
70negative regulation of granulocyte differentiation (GO:0030853)2.79651017
71negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.79553541
72response to acidic pH (GO:0010447)2.79357141
73negative T cell selection (GO:0043383)2.78672778
74regulation of cholesterol homeostasis (GO:2000188)2.76680898
75regulation of hydrogen peroxide-induced cell death (GO:1903205)2.76569484
76regulation of mast cell activation involved in immune response (GO:0033006)2.74683397
77ferric iron transport (GO:0015682)2.74010368
78trivalent inorganic cation transport (GO:0072512)2.74010368
792-oxoglutarate metabolic process (GO:0006103)2.73958780
80regulation of synapse structural plasticity (GO:0051823)2.73848276
81positive regulation of protein kinase C signaling (GO:0090037)2.73751908
82neuromuscular process controlling posture (GO:0050884)2.72806120
83regulation of B cell receptor signaling pathway (GO:0050855)2.72697880
84regulation of granulocyte differentiation (GO:0030852)2.72462017
85regulation of nuclease activity (GO:0032069)2.72424937
86cellular response to interleukin-15 (GO:0071350)2.70079484
87cytoskeletal anchoring at plasma membrane (GO:0007016)2.69834061
88regulation of leukocyte degranulation (GO:0043300)2.69748920
89negative thymic T cell selection (GO:0045060)2.69586078
90response to muscle activity (GO:0014850)2.68919074
91positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.68220678
92positive regulation of granulocyte differentiation (GO:0030854)2.68129726
93potassium ion import (GO:0010107)2.67388365
94cellular response to toxic substance (GO:0097237)2.67063861
95positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.66969970
96positive regulation of T cell mediated cytotoxicity (GO:0001916)2.65685923
97intra-Golgi vesicle-mediated transport (GO:0006891)2.65604468
98multicellular organism reproduction (GO:0032504)2.65572341
99negative regulation of smooth muscle cell proliferation (GO:0048662)2.64855540
100lysine metabolic process (GO:0006553)2.64566385
101lysine catabolic process (GO:0006554)2.64566385
102regulation of defense response to virus by virus (GO:0050690)2.63957461
103relaxation of smooth muscle (GO:0044557)2.62845048
104energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.61766309
105ATP hydrolysis coupled proton transport (GO:0015991)2.61766309
106mitochondrion degradation (GO:0000422)2.61282820
107cellular response to lithium ion (GO:0071285)2.61107945
108phosphatidylinositol dephosphorylation (GO:0046856)2.60982393
109negative regulation of interleukin-12 production (GO:0032695)2.60642043
110regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.60363893
111endoplasmic reticulum unfolded protein response (GO:0030968)2.60050205
112immunoglobulin mediated immune response (GO:0016064)2.59751655
113response to interleukin-15 (GO:0070672)2.59511806
114alpha-linolenic acid metabolic process (GO:0036109)2.59287123
115germinal center formation (GO:0002467)2.57577812
116neurotransmitter-gated ion channel clustering (GO:0072578)2.56595932
117phospholipid dephosphorylation (GO:0046839)2.56064491
118tricarboxylic acid cycle (GO:0006099)2.54805050
119positive regulation by organism of defense response of other organism involved in symbiotic interact2.54632016
120modulation by symbiont of host immune response (GO:0052553)2.54632016
121positive regulation by symbiont of host defense response (GO:0052509)2.54632016
122modulation by symbiont of host defense response (GO:0052031)2.54632016
123modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.54632016
124modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.54632016
125neuromuscular process controlling balance (GO:0050885)2.52720198
126glycine transport (GO:0015816)2.52239794
127regulation of T cell mediated cytotoxicity (GO:0001914)2.51781996
128positive T cell selection (GO:0043368)2.51451626
129regulation of clathrin-mediated endocytosis (GO:2000369)2.49863504
130ER-nucleus signaling pathway (GO:0006984)2.48443608
131CDP-diacylglycerol metabolic process (GO:0046341)2.48409409
132regulation of translational termination (GO:0006449)2.48164998
133negative regulation of organelle assembly (GO:1902116)2.47193862
134positive regulation of natural killer cell differentiation (GO:0032825)2.46078825
135response to peptidoglycan (GO:0032494)2.45954414
136cellular response to unfolded protein (GO:0034620)2.45192352
137regulation of glutamate receptor signaling pathway (GO:1900449)2.44280137
138negative regulation of response to reactive oxygen species (GO:1901032)2.43605409
139fatty acid homeostasis (GO:0055089)2.42477100
140leukocyte degranulation (GO:0043299)2.42037079
141negative regulation of autophagy (GO:0010507)2.41747795
142aspartate family amino acid catabolic process (GO:0009068)2.41429703
143regulation of ARF GTPase activity (GO:0032312)2.40900048
144neutral amino acid transport (GO:0015804)2.40102944
145regulation of regulated secretory pathway (GO:1903305)2.39473421
146dicarboxylic acid biosynthetic process (GO:0043650)2.38513229
147antigen processing and presentation via MHC class Ib (GO:0002475)2.38504125
148positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.38125071
149dicarboxylic acid catabolic process (GO:0043649)2.37613126
150macrophage activation involved in immune response (GO:0002281)2.37503930
151response to type I interferon (GO:0034340)2.37224210
152G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.37076698
153myeloid cell activation involved in immune response (GO:0002275)2.36963224
154leukocyte aggregation (GO:0070486)2.36801070
155regulation of amyloid precursor protein catabolic process (GO:1902991)2.36743985
156oligosaccharide biosynthetic process (GO:0009312)2.36589446
157regulation of beta-amyloid formation (GO:1902003)2.36094575
158L-serine transport (GO:0015825)2.35930400
159succinate metabolic process (GO:0006105)2.35926967
160positive regulation of histone deacetylation (GO:0031065)2.35539921
161vesicle transport along microtubule (GO:0047496)2.35190688
162gamma-aminobutyric acid transport (GO:0015812)2.35020198
163apoptotic cell clearance (GO:0043277)2.34952002
164low-density lipoprotein particle clearance (GO:0034383)2.33027183
165peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.33003049
166antigen processing and presentation of exogenous peptide antigen via MHC class II (GO:0019886)2.32858113
167positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.32017954
168regulation of mast cell activation (GO:0033003)2.31874698
169negative regulation of T cell apoptotic process (GO:0070233)2.31684490
170cellular response to topologically incorrect protein (GO:0035967)2.30835488
171protein localization to endosome (GO:0036010)2.30157809
172L-fucose catabolic process (GO:0042355)2.28881139
173fucose catabolic process (GO:0019317)2.28881139
174L-fucose metabolic process (GO:0042354)2.28881139
175barbed-end actin filament capping (GO:0051016)2.28581950
176antigen processing and presentation of peptide antigen via MHC class II (GO:0002495)2.27738727
177antigen processing and presentation of peptide or polysaccharide antigen via MHC class II (GO:0002502.27738727
178cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.27525529
179regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.27265864
180regulation of fatty acid beta-oxidation (GO:0031998)2.27237053
181negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.27170027
182cerebellar Purkinje cell differentiation (GO:0021702)2.26268427
183muscle cell cellular homeostasis (GO:0046716)2.25858773
184beta-amyloid metabolic process (GO:0050435)2.25783217
185positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.25607074
186positive regulation of lamellipodium assembly (GO:0010592)2.25501521
187gluconeogenesis (GO:0006094)2.25306553
188positive regulation of lymphocyte migration (GO:2000403)2.25270163
189cellular extravasation (GO:0045123)2.24610724
190B cell receptor signaling pathway (GO:0050853)2.23487767
191mRNA cleavage (GO:0006379)2.22844514

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse6.23210250
2BP1_19119308_ChIP-ChIP_Hs578T_Human6.02255636
3ESR1_20079471_ChIP-ChIP_T-47D_Human2.89922617
4MYC_22102868_ChIP-Seq_BL_Human2.67913585
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.66740004
6CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.50386703
7RARB_27405468_Chip-Seq_BRAIN_Mouse2.46923807
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.46300202
9ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.35325646
10EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.31478597
11GATA1_22025678_ChIP-Seq_K562_Human2.21475213
12LXR_22292898_ChIP-Seq_THP-1_Human2.19557455
13CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.17121369
14MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.13657018
15E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.08226542
16ZFP281_18757296_ChIP-ChIP_E14_Mouse2.07593331
17CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.99626345
18KDM2B_26808549_Chip-Seq_DND41_Human1.97934079
19KDM2B_26808549_Chip-Seq_SUP-B15_Human1.94993513
20EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.87046605
21VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.84265670
22VDR_24763502_ChIP-Seq_THP-1_Human1.84101481
23THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.83893751
24SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.83257230
25GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.80547261
26RUNX_20019798_ChIP-Seq_JUKART_Human1.80274625
27TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.79436758
28MAF_26560356_Chip-Seq_TH2_Human1.78869720
29CLOCK_20551151_ChIP-Seq_293T_Human1.78105664
30DNAJC2_21179169_ChIP-ChIP_NT2_Human1.78087975
31STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.77959752
32VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.77737592
33IKZF1_21737484_ChIP-ChIP_HCT116_Human1.77663519
34RXR_22158963_ChIP-Seq_LIVER_Mouse1.76492744
35NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.74872253
36TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.73646908
37SCL_19346495_ChIP-Seq_HPC-7_Human1.73321394
38REST_18959480_ChIP-ChIP_MESCs_Mouse1.72518168
39FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.71528744
40PPARA_22158963_ChIP-Seq_LIVER_Mouse1.71409201
41DROSHA_22980978_ChIP-Seq_HELA_Human1.71038708
42STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.71034998
43STAT4_19710469_ChIP-ChIP_TH1__Mouse1.69956582
44SPI1_23127762_ChIP-Seq_K562_Human1.69515860
45TCF7_22412390_ChIP-Seq_EML_Mouse1.64212760
46KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.62505538
47PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.62247119
48ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.61834743
49KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.60494576
50MYB_26560356_Chip-Seq_TH1_Human1.58150094
51MYB_26560356_Chip-Seq_TH2_Human1.57363910
52GATA1_19941827_ChIP-Seq_MEL_Mouse1.57006308
53KDM2B_26808549_Chip-Seq_K562_Human1.55338894
54VDR_21846776_ChIP-Seq_THP-1_Human1.53544733
55FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.50710924
56GATA1_19941826_ChIP-Seq_K562_Human1.48379624
57DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.48071488
58RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.47873601
59EGR1_19374776_ChIP-ChIP_THP-1_Human1.47627762
60MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.47362585
61GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.45710840
62TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.44287752
63NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.43279080
64ELF1_20517297_ChIP-Seq_JURKAT_Human1.40938775
65RACK7_27058665_Chip-Seq_MCF-7_Human1.40069843
66P68_20966046_ChIP-Seq_HELA_Human1.39873724
67VDR_24787735_ChIP-Seq_THP-1_Human1.39409415
68LXR_22158963_ChIP-Seq_LIVER_Mouse1.39397630
69MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.39296982
70ELK3_25401928_ChIP-Seq_HUVEC_Human1.39084508
71SPI1_23547873_ChIP-Seq_NB4_Human1.37557312
72REST_21632747_ChIP-Seq_MESCs_Mouse1.33405611
73FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.32389066
74SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.31670157
75SPI1_20517297_ChIP-Seq_HL60_Human1.30866738
76* TFEB_21752829_ChIP-Seq_HELA_Human1.30799928
77FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.30582678
78LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.29424588
79RUNX1_22412390_ChIP-Seq_EML_Mouse1.27972271
80SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.27445470
81BCL6_27268052_Chip-Seq_Bcells_Human1.26824896
82E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.26570373
83CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.25789730
84P300_27058665_Chip-Seq_ZR-75-30cells_Human1.24825379
85IRF8_21731497_ChIP-ChIP_J774_Mouse1.24616487
86SMC4_20622854_ChIP-Seq_HELA_Human1.22778872
87ESR2_21235772_ChIP-Seq_MCF-7_Human1.22425273
88TET1_21490601_ChIP-Seq_MESCs_Mouse1.22404287
89TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21498948
90PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.20710896
91BCOR_27268052_Chip-Seq_Bcells_Human1.20245168
92MAF_26560356_Chip-Seq_TH1_Human1.20134723
93LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.20122517
94SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.18284841
95IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.17067074
96ERG_21242973_ChIP-ChIP_JURKAT_Human1.16875056
97UTX_26944678_Chip-Seq_JUKART_Human1.16581986
98ESR1_15608294_ChIP-ChIP_MCF-7_Human1.16417501
99NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.16010056
100RAC3_21632823_ChIP-Seq_H3396_Human1.14851683
101GATA2_21666600_ChIP-Seq_HMVEC_Human1.14612515
102CTCF_20526341_ChIP-Seq_ESCs_Human1.13323476
103IGF1R_20145208_ChIP-Seq_DFB_Human1.13297643
104ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.12812866
105SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.12562860
106PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12107602
107NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.11739515
108TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11510009
109IRF8_22096565_ChIP-ChIP_GC-B_Human1.11429125
110* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.11099726
111ZFP281_27345836_Chip-Seq_ESCs_Mouse1.11081457
112ERA_21632823_ChIP-Seq_H3396_Human1.10592841
113* MITF_21258399_ChIP-Seq_MELANOMA_Human1.09186621
114KDM2B_26808549_Chip-Seq_JURKAT_Human1.06798575
115* GATA3_26560356_Chip-Seq_TH2_Human1.06670269
116* CREB1_26743006_Chip-Seq_LNCaP_Human1.06647243
117RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.06015182
118STAT1_20625510_ChIP-Seq_HELA_Human1.05050175
119CIITA_25753668_ChIP-Seq_RAJI_Human1.04505704
120TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.04163327
121RARG_19884340_ChIP-ChIP_MEFs_Mouse1.04145366
122RUNX1_27514584_Chip-Seq_MCF-7_Human1.03809610
123TET1_21451524_ChIP-Seq_MESCs_Mouse1.03341928
124E2F1_20622854_ChIP-Seq_HELA_Human1.03307152
125SA1_27219007_Chip-Seq_ERYTHROID_Human1.03159435
126FOXA2_19822575_ChIP-Seq_HepG2_Human1.02739523
127* CTCF_21964334_ChIP-Seq_BJAB-B_Human1.02634956
128RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02531497
129MYB_21317192_ChIP-Seq_ERMYB_Mouse1.02466979
130SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.02425723
131PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01871533
132* GATA3_27048872_Chip-Seq_THYMUS_Human1.01517268
133EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.01240939
134ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01008749
135SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.99752025
136GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.99434156
137WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.98174945
138ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98134217
139PHF8_20622854_ChIP-Seq_HELA_Human0.98134004
140BRD4_27068464_Chip-Seq_AML-cells_Mouse0.98034066
141SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.95669431
142IRF8_27001747_Chip-Seq_BMDM_Mouse0.94605124
143MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.94285454
144NOTCH1_21737748_ChIP-Seq_TLL_Human0.94067546
145* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.94021286
146POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.93377512
147TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92995104
148* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92676305
149STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.91040685
150CTCF_27219007_Chip-Seq_Bcells_Human0.90739762
151OCT4_19829295_ChIP-Seq_ESCs_Human0.90191826
152P300_27268052_Chip-Seq_Bcells_Human0.89947223
153NANOG_20526341_ChIP-Seq_ESCs_Human0.89873827
154OCT4_20526341_ChIP-Seq_ESCs_Human0.89440274
155TP63_22573176_ChIP-Seq_HFKS_Human0.88842640

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology3.72609810
2MP0004859_abnormal_synaptic_plasticity3.55866959
3MP0008004_abnormal_stomach_pH3.54754219
4MP0003172_abnormal_lysosome_physiology3.26413383
5MP0003329_amyloid_beta_deposits3.15382107
6MP0002909_abnormal_adrenal_gland3.02563620
7MP0003763_abnormal_thymus_physiology2.92270355
8MP0003806_abnormal_nucleotide_metabolis2.74649474
9MP0003183_abnormal_peptide_metabolism2.70485690
10MP0000604_amyloidosis2.69961971
11MP0003436_decreased_susceptibility_to2.63971916
12MP0009780_abnormal_chondrocyte_physiolo2.58143005
13MP0009840_abnormal_foam_cell2.56663497
14MP0002132_abnormal_respiratory_system2.51081171
15MP0003724_increased_susceptibility_to2.48860243
16MP0001835_abnormal_antigen_presentation2.32449079
17MP0000013_abnormal_adipose_tissue2.32150007
18MP0008961_abnormal_basal_metabolism2.32007453
19MP0005671_abnormal_response_to2.26219449
20MP0004381_abnormal_hair_follicle2.19090884
21MP0004858_abnormal_nervous_system2.18536583
22MP0003635_abnormal_synaptic_transmissio2.11527872
23MP0009785_altered_susceptibility_to2.09673447
24MP0002822_catalepsy2.08543742
25MP0005025_abnormal_response_to2.07616327
26MP0002419_abnormal_innate_immunity2.05848725
27MP0003300_gastrointestinal_ulcer2.03576135
28MP0005387_immune_system_phenotype2.02065524
29MP0001790_abnormal_immune_system2.02065524
30MP0005000_abnormal_immune_tolerance1.97845872
31MP0001800_abnormal_humoral_immune1.97025438
32MP0003705_abnormal_hypodermis_morpholog1.91837889
33MP0002148_abnormal_hypersensitivity_rea1.89637433
34MP0000749_muscle_degeneration1.86972736
35MP0003191_abnormal_cellular_cholesterol1.84420067
36MP0002064_seizures1.83569686
37MP0002420_abnormal_adaptive_immunity1.83196355
38MP0001819_abnormal_immune_cell1.79564942
39MP0000343_altered_response_to1.73690206
40MP0002723_abnormal_immune_serum1.73130741
41MP0002452_abnormal_antigen_presenting1.72327691
42MP0000003_abnormal_adipose_tissue1.71179582
43MP0005410_abnormal_fertilization1.71098821
44MP0003303_peritoneal_inflammation1.69860236
45MP0004130_abnormal_muscle_cell1.68435466
46MP0002653_abnormal_ependyma_morphology1.68327554
47MP0003315_abnormal_perineum_morphology1.68308801
48MP0003690_abnormal_glial_cell1.65154751
49MP0005166_decreased_susceptibility_to1.61460760
50MP0003828_pulmonary_edema1.59039227
51MP0003633_abnormal_nervous_system1.53996763
52MP0010386_abnormal_urinary_bladder1.53562253
53MP0004885_abnormal_endolymph1.51253158
54MP0000465_gastrointestinal_hemorrhage1.50851173
55MP0003075_altered_response_to1.46151763
56MP0002998_abnormal_bone_remodeling1.45355862
57MP0009278_abnormal_bone_marrow1.44653253
58MP0002063_abnormal_learning/memory/cond1.43966578
59MP0010329_abnormal_lipoprotein_level1.41941291
60MP0002405_respiratory_system_inflammati1.40146264
61MP0009046_muscle_twitch1.39104743
62MP0000015_abnormal_ear_pigmentation1.36646237
63MP0008569_lethality_at_weaning1.36361810
64MP0005365_abnormal_bile_salt1.35948366
65MP0004043_abnormal_pH_regulation1.34711868
66MP0004270_analgesia1.32288147
67MP0000716_abnormal_immune_system1.30901211
68MP0001756_abnormal_urination1.30223726
69MP0003656_abnormal_erythrocyte_physiolo1.27833073
70MP0009745_abnormal_behavioral_response1.27774875
71MP0001845_abnormal_inflammatory_respons1.27774050
72MP0004233_abnormal_muscle_weight1.27605488
73MP0002166_altered_tumor_susceptibility1.25453629
74MP0002139_abnormal_hepatobiliary_system1.24126186
75MP0005451_abnormal_body_composition1.23727061
76MP0000569_abnormal_digit_pigmentation1.22765782
77MP0002078_abnormal_glucose_homeostasis1.22366366
78MP0003634_abnormal_glial_cell1.21047469
79MP0002398_abnormal_bone_marrow1.20231350
80MP0010155_abnormal_intestine_physiology1.19768772
81MP0000703_abnormal_thymus_morphology1.17748889
82MP0001533_abnormal_skeleton_physiology1.16042989
83MP0005375_adipose_tissue_phenotype1.13977082
84MP0004811_abnormal_neuron_physiology1.13543544
85MP0001664_abnormal_digestion1.13141631
86MP0001502_abnormal_circadian_rhythm1.13038398
87MP0003879_abnormal_hair_cell1.12863863
88MP0003631_nervous_system_phenotype1.11902493
89MP0001873_stomach_inflammation1.09794589
90MP0002572_abnormal_emotion/affect_behav1.09544991
91MP0000609_abnormal_liver_physiology1.08960458
92MP0005397_hematopoietic_system_phenotyp1.08405288
93MP0001545_abnormal_hematopoietic_system1.08405288
94MP0003195_calcinosis1.08375215
95MP0008260_abnormal_autophagy1.07290347
96MP0010352_gastrointestinal_tract_polyps1.07231668
97MP0002722_abnormal_immune_system1.07207141
98MP0009333_abnormal_splenocyte_physiolog1.06994078
99MP0005646_abnormal_pituitary_gland1.06325752
100MP0003045_fibrosis1.06235159
101MP0002733_abnormal_thermal_nociception1.05893711
102MP0005535_abnormal_body_temperature1.04521528
103MP0005174_abnormal_tail_pigmentation1.03181107
104MP0005464_abnormal_platelet_physiology1.02392639
105MP0004484_altered_response_of1.02218141
106MP0003646_muscle_fatigue1.02133933
107MP0002118_abnormal_lipid_homeostasis1.01418095
108MP0009764_decreased_sensitivity_to1.00805222
109MP0002877_abnormal_melanocyte_morpholog1.00489117
110MP0004036_abnormal_muscle_relaxation1.00455399
111MP0002160_abnormal_reproductive_system1.00339789
112MP0002933_joint_inflammation1.00220410
113MP0008469_abnormal_protein_level0.98701823
114MP0000920_abnormal_myelination0.98402933
115MP0005670_abnormal_white_adipose0.97841151
116MP0004084_abnormal_cardiac_muscle0.97279088
117MP0002837_dystrophic_cardiac_calcinosis0.96423576
118MP0005584_abnormal_enzyme/coenzyme_acti0.95650108
119MP0005310_abnormal_salivary_gland0.94904033
120MP0002693_abnormal_pancreas_physiology0.94900893
121MP0005332_abnormal_amino_acid0.93944915
122MP0000681_abnormal_thyroid_gland0.93943587
123MP0006036_abnormal_mitochondrial_physio0.93594439
124MP0003866_abnormal_defecation0.92793090
125MP0002429_abnormal_blood_cell0.92428555
126MP0000689_abnormal_spleen_morphology0.92396739
127MP0003632_abnormal_nervous_system0.92099141
128MP0000678_abnormal_parathyroid_gland0.91899332
129MP0002089_abnormal_postnatal_growth/wei0.91114678
130MP0002090_abnormal_vision0.89292130
131MP0002229_neurodegeneration0.88243182
132MP0004185_abnormal_adipocyte_glucose0.87467699
133MP0002272_abnormal_nervous_system0.86866504
134MP0003566_abnormal_cell_adhesion0.86738936
135MP0000371_diluted_coat_color0.86579743
136MP0005448_abnormal_energy_balance0.84183912
137MP0002138_abnormal_hepatobiliary_system0.83990872
138MP0005647_abnormal_sex_gland0.83881651
139MP0004947_skin_inflammation0.82393441
140MP0005075_abnormal_melanosome_morpholog0.82366122
141MP0001905_abnormal_dopamine_level0.81303760
142MP0008874_decreased_physiological_sensi0.81119903
143MP0002067_abnormal_sensory_capabilities0.80937475
144MP0004883_abnormal_blood_vessel0.80864779
145MP0005076_abnormal_cell_differentiation0.78815182
146MP0003136_yellow_coat_color0.78631269
147MP0001501_abnormal_sleep_pattern0.77714092
148MP0001944_abnormal_pancreas_morphology0.76736577
149MP0001970_abnormal_pain_threshold0.76708375
150MP0005164_abnormal_response_to0.76541833
151MP0001440_abnormal_grooming_behavior0.76218692
152MP0005360_urolithiasis0.75888064
153MP0003953_abnormal_hormone_level0.75183325
154MP0009643_abnormal_urine_homeostasis0.75078576
155MP0006082_CNS_inflammation0.74561934
156MP0005666_abnormal_adipose_tissue0.73493623
157MP0001968_abnormal_touch/_nociception0.73464626
158MP0002332_abnormal_exercise_endurance0.73421706
159MP0005319_abnormal_enzyme/_coenzyme0.73327344
160MP0004510_myositis0.73303834
161MP0001958_emphysema0.73142846
162MP0001853_heart_inflammation0.73086851
163MP0003795_abnormal_bone_structure0.72773167
164MP0000955_abnormal_spinal_cord0.72356582
165MP0001764_abnormal_homeostasis0.72338836
166MP0001849_ear_inflammation0.72298362
167MP0000747_muscle_weakness0.72096721
168MP0002069_abnormal_eating/drinking_beha0.72011975
169MP0005334_abnormal_fat_pad0.71307167
170MP0002066_abnormal_motor_capabilities/c0.71007910
171MP0001765_abnormal_ion_homeostasis0.70699735
172MP0003283_abnormal_digestive_organ0.70512609
173MP0010307_abnormal_tumor_latency0.70481397
174MP0005167_abnormal_blood-brain_barrier0.69867184
175MP0000685_abnormal_immune_system0.68692602

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the columella (HP:0009929)5.68419306
2Increased cerebral lipofuscin (HP:0011813)4.21526924
3Thoracic kyphosis (HP:0002942)3.94795463
4Abnormality of the lower motor neuron (HP:0002366)3.76564022
5Eosinophilia (HP:0001880)3.52970404
6Visual hallucinations (HP:0002367)3.52162850
7Reduced antithrombin III activity (HP:0001976)3.42741128
8Dysostosis multiplex (HP:0000943)3.40003012
9Increased neuronal autofluorescent lipopigment (HP:0002074)3.37932201
10Granulocytopenia (HP:0001913)3.28066729
11Hyporeflexia of lower limbs (HP:0002600)3.26323936
12Colitis (HP:0002583)3.22397025
13Exercise-induced myalgia (HP:0003738)3.18800686
14Supranuclear gaze palsy (HP:0000605)3.16638925
15Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)3.13448647
16Elevated erythrocyte sedimentation rate (HP:0003565)3.06234988
17Resting tremor (HP:0002322)3.05021689
18Ventricular fibrillation (HP:0001663)3.03109125
19Eczematoid dermatitis (HP:0000976)3.01656902
20Myositis (HP:0100614)2.99545659
21Abnormality of macrophages (HP:0004311)2.96706800
22Clumsiness (HP:0002312)2.96614232
23Global brain atrophy (HP:0002283)2.95532577
24Abnormal delayed hypersensitivity skin test (HP:0002963)2.95176168
25Inflammation of the large intestine (HP:0002037)2.93318768
26Absent rod-and cone-mediated responses on ERG (HP:0007688)2.92193411
27Autoimmune thrombocytopenia (HP:0001973)2.90660944
28Hand muscle atrophy (HP:0009130)2.86865882
29Abnormality of liposaccharide metabolism (HP:0010968)2.86785948
30Abnormality of glycosphingolipid metabolism (HP:0004343)2.86785948
31Abnormality of glycolipid metabolism (HP:0010969)2.86785948
32Focal motor seizures (HP:0011153)2.80716371
33Dysmetric saccades (HP:0000641)2.78364171
34Gastrointestinal inflammation (HP:0004386)2.77925682
35Pustule (HP:0200039)2.76022355
36Recurrent fungal infections (HP:0002841)2.75886231
37Urinary glycosaminoglycan excretion (HP:0003541)2.70074622
38Mucopolysacchariduria (HP:0008155)2.70074622
39Depression (HP:0000716)2.67187300
40Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.62547005
41Distal upper limb amyotrophy (HP:0007149)2.62205899
42Upper limb amyotrophy (HP:0009129)2.62205899
43Ketoacidosis (HP:0001993)2.60967453
44Abnormality of the thoracic spine (HP:0100711)2.60943416
45Orchitis (HP:0100796)2.60487007
46Stomatitis (HP:0010280)2.59686134
47Focal seizures (HP:0007359)2.59126850
48Centrally nucleated skeletal muscle fibers (HP:0003687)2.58195264
49Hypoglycemic seizures (HP:0002173)2.56810151
50Abnormality of eosinophils (HP:0001879)2.55771191
51Abnormality of the frontal sinuses (HP:0002687)2.53297087
52Abnormality of polysaccharide metabolism (HP:0011012)2.51999207
53Abnormality of glycosaminoglycan metabolism (HP:0004371)2.51999207
54Abnormality of mucopolysaccharide metabolism (HP:0011020)2.51999207
55Cerebral inclusion bodies (HP:0100314)2.51689942
56Axonal loss (HP:0003447)2.51497953
57Neuronal loss in central nervous system (HP:0002529)2.49459613
58Easy fatigability (HP:0003388)2.48497740
59Abnormality of the pancreatic islet cells (HP:0006476)2.48496190
60Abnormality of endocrine pancreas physiology (HP:0012093)2.48496190
61Upper motor neuron abnormality (HP:0002127)2.45461753
62Recurrent bacterial skin infections (HP:0005406)2.42245190
63Leukocytosis (HP:0001974)2.40478857
64Abnormality of lateral ventricle (HP:0030047)2.40312102
65Pancreatic islet-cell hyperplasia (HP:0004510)2.38742786
66Vacuolated lymphocytes (HP:0001922)2.38642694
67Recurrent abscess formation (HP:0002722)2.38108559
68Postural tremor (HP:0002174)2.34691129
69Retinal atrophy (HP:0001105)2.34462074
70Truncal ataxia (HP:0002078)2.33623162
71Retrobulbar optic neuritis (HP:0100654)2.31620198
72Optic neuritis (HP:0100653)2.31620198
73Cerebral aneurysm (HP:0004944)2.29477707
74Loss of speech (HP:0002371)2.27719599
75Autoimmune hemolytic anemia (HP:0001890)2.24730002
76Chronic obstructive pulmonary disease (HP:0006510)2.23301140
77Obstructive lung disease (HP:0006536)2.23301140
78Impaired smooth pursuit (HP:0007772)2.22761186
79J-shaped sella turcica (HP:0002680)2.22177527
80Panhypogammaglobulinemia (HP:0003139)2.20098704
81Absent/shortened dynein arms (HP:0200106)2.19027473
82Dynein arm defect of respiratory motile cilia (HP:0012255)2.19027473
83Pheochromocytoma (HP:0002666)2.18147771
84Abnormality of the periventricular white matter (HP:0002518)2.16656803
85Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.16608350
86Hyperinsulinemic hypoglycemia (HP:0000825)2.14851183
87Ankle clonus (HP:0011448)2.14351443
88Urinary urgency (HP:0000012)2.13943643
89Ocular albinism (HP:0001107)2.13225507
90Unsteady gait (HP:0002317)2.12119955
91Generalized tonic-clonic seizures (HP:0002069)2.11908457
92Recurrent cutaneous fungal infections (HP:0011370)2.11660258
93Chronic mucocutaneous candidiasis (HP:0002728)2.11660258
94Hematochezia (HP:0002573)2.10348958
95Abnormal rod and cone electroretinograms (HP:0008323)2.08060887
96Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.07352325
97Vasculitis (HP:0002633)2.06855567
98Abnormality of ocular smooth pursuit (HP:0000617)2.06337089
99Neurofibrillary tangles (HP:0002185)2.05782861
100Meningitis (HP:0001287)2.05311091
101Postural instability (HP:0002172)2.04357607
102Hemiplegia (HP:0002301)2.02826089
103Abnormality of T cell number (HP:0011839)2.02777779
104Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.02406395
105Spastic gait (HP:0002064)2.02190184
106Spinal rigidity (HP:0003306)2.01672431
107Myokymia (HP:0002411)2.01209585
108Recurrent viral infections (HP:0004429)2.00992918
109Lip pit (HP:0100267)2.00713635
110Impaired vibration sensation in the lower limbs (HP:0002166)2.00657090
111Neoplasm of the heart (HP:0100544)2.00171253
112Abnormality of the nasal mucosa (HP:0000433)2.00088020
113Absence seizures (HP:0002121)2.00068727
114Gout (HP:0001997)1.99087253
115Self-mutilation (HP:0000742)1.98066295
116Poor head control (HP:0002421)1.97465223
117Gonadal dysgenesis (HP:0000133)1.96847033
118Amyotrophic lateral sclerosis (HP:0007354)1.96267097
119Abnormal social behavior (HP:0012433)1.96129603
120Impaired social interactions (HP:0000735)1.96129603
121Insomnia (HP:0100785)1.95388194
122Large for gestational age (HP:0001520)1.95188451
123Cerebellar dysplasia (HP:0007033)1.94586121
124Type II lissencephaly (HP:0007260)1.93588744
125Death in childhood (HP:0003819)1.93154360
126Ketosis (HP:0001946)1.92837108
127Mediastinal lymphadenopathy (HP:0100721)1.92330931
128Prolonged QT interval (HP:0001657)1.92102541
129Abnormal ciliary motility (HP:0012262)1.90840873
130Decreased circulating renin level (HP:0003351)1.90556475
131Enlarged penis (HP:0000040)1.90386755
132Abnormality of the motor neurons (HP:0002450)1.90038912
133Abnormal neuron morphology (HP:0012757)1.90038912
134Increased CSF protein (HP:0002922)1.89776863
135Diaphragmatic weakness (HP:0009113)1.89450320
136Oligomenorrhea (HP:0000876)1.89348235
137Hypoglycemic coma (HP:0001325)1.88499390
138Bulbar palsy (HP:0001283)1.87710951
139Progressive neurologic deterioration (HP:0002344)1.87354001
140Increased variability in muscle fiber diameter (HP:0003557)1.85883574
141Neuroendocrine neoplasm (HP:0100634)1.85755716
142Spastic tetraparesis (HP:0001285)1.85690199
143Nasal polyposis (HP:0100582)1.84365363
144Cholelithiasis (HP:0001081)1.83372181
145Hypsarrhythmia (HP:0002521)1.82453622
146Clonus (HP:0002169)1.82065355
147Macroorchidism (HP:0000053)1.81747774
148Recurrent skin infections (HP:0001581)1.81571334
149T lymphocytopenia (HP:0005403)1.81472377
150Abnormality of T cells (HP:0002843)1.80992658
151Gastrointestinal infarctions (HP:0005244)1.80924846
152EEG with generalized epileptiform discharges (HP:0011198)1.80730244
153Papilledema (HP:0001085)1.80196145
154Epileptiform EEG discharges (HP:0011182)1.80031961
155Hypokalemic alkalosis (HP:0001949)1.79510257
156Epileptic encephalopathy (HP:0200134)1.79451299
157Dementia (HP:0000726)1.79245794
158Spinal muscular atrophy (HP:0007269)1.79029658
159Prolonged bleeding time (HP:0003010)1.78815941
160Petechiae (HP:0000967)1.78636244
161Polyneuropathy (HP:0001271)1.78592684
162Dialeptic seizures (HP:0011146)1.78203261
163Growth hormone excess (HP:0000845)1.77803085
164Frequent falls (HP:0002359)1.76747755
165Calf muscle hypertrophy (HP:0008981)1.76518240
166Spontaneous hematomas (HP:0007420)1.76504846
167Decreased activity of mitochondrial respiratory chain (HP:0008972)1.76384008
168Striae distensae (HP:0001065)1.76125746
169Abnormal gallbladder morphology (HP:0012437)1.75971716
170Hyperglycemia (HP:0003074)1.75916344
171Insulin-resistant diabetes mellitus (HP:0000831)1.73845793
172Abnormal eating behavior (HP:0100738)1.73146936
173Conjugated hyperbilirubinemia (HP:0002908)1.71507547
174Abnormality of saccadic eye movements (HP:0000570)1.71276621
175Urinary bladder sphincter dysfunction (HP:0002839)1.70561760
176Apathy (HP:0000741)1.68585118
177Rapidly progressive (HP:0003678)1.67940411
178Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.67873460
179Long toe (HP:0010511)1.66977725
180Interstitial pulmonary disease (HP:0006530)1.66887505

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PINK16.84255879
2MARK34.69301027
3TRIB34.42060813
4INSRR3.16951994
5TLK12.76442650
6CAMKK12.47988392
7ERN12.42752349
8PKN22.30264278
9PASK2.25969659
10MAP3K92.13378533
11SCYL22.10275910
12TNK22.05619012
13DAPK21.94891281
14LMTK21.89308735
15KSR21.81846011
16FGFR41.80929421
17MAP3K41.76218337
18NTRK31.75766510
19RET1.64964062
20NME21.58355227
21DAPK11.57063925
22NTRK11.56382654
23MAP2K41.53191024
24FRK1.47080067
25MAPK121.46788999
26GRK61.45575525
27TAOK11.44531547
28PDK31.43981884
29PDK41.43981884
30TSSK61.41721841
31OBSCN1.41383674
32MYLK1.40745411
33BTK1.37941696
34LATS11.37091797
35MAP3K21.35836647
36MAP3K121.35256215
37PDGFRA1.34897889
38EEF2K1.33637079
39SIK11.31583009
40PTK61.30421944
41ICK1.29848660
42NEK21.29340237
43JAK11.28999340
44PRKCH1.28642749
45CAMKK21.26848135
46PAK61.25901099
47MAP4K11.25639487
48PRPF4B1.25572295
49BCKDK1.19987610
50BLK1.18335264
51MINK11.17430777
52MAP3K31.16617391
53ALK1.15408539
54ZAP701.15146948
55PRKCQ1.13648580
56RIPK41.12703192
57TYK21.11690494
58PAK41.07925430
59MAP3K131.07311817
60TYRO31.07099181
61MAPKAPK31.06679081
62SGK31.03546849
63MOS1.03426856
64MAP2K31.03188612
65ARAF1.01712213
66PRKD31.00446431
67TAOK30.99277595
68NEK10.99173919
69SIK20.98591501
70ZAK0.96043139
71CSNK1A1L0.95295878
72JAK20.92710609
73EPHB10.91937706
74RIPK10.91780889
75RPS6KA50.88688198
76NLK0.88669668
77MELK0.88532198
78CDK30.87434871
79MAP2K70.87341614
80CSNK1G30.87262846
81FGFR30.84075292
82MAP3K10.83102116
83TXK0.79835387
84PDK10.79600329
85CDK120.79332950
86CDK50.78429258
87STK380.78158014
88TESK10.77691517
89IKBKE0.75524957
90CDK190.75463013
91IRAK20.74395972
92TBK10.72737647
93LRRK20.72351261
94NTRK20.71641575
95PDPK10.70997286
96TESK20.70312594
97ITK0.68657008
98CSK0.67960440
99MAPK150.66338403
100IRAK40.65805466
101TTN0.65733640
102MAP2K60.65653051
103CAMK1D0.65556023
104MARK20.64275690
105RPS6KB10.63625355
106HIPK20.63368676
107BMX0.62788963
108SGK4940.62192169
109SGK2230.62192169
110EPHA30.62173579
111EPHA40.61453930
112FES0.60633003
113IKBKB0.60319691
114MAP3K100.60286956
115CSF1R0.60066417
116BRD40.59421267
117SGK20.59189258
118MUSK0.59052320
119PDK20.58746034
120RPS6KA20.58301776
121PRKG20.57860345
122PTK2B0.56723393
123FGR0.56622446
124PTK20.55301398
125KIT0.54742349
126MAP3K70.54527550
127PIK3CA0.53276152
128TRPM70.53219711
129FLT30.52625980
130RPS6KC10.52568242
131RPS6KL10.52568242
132CSNK1G20.52533203
133KSR10.50750618
134PLK20.50313206
135LCK0.50164445
136CAMK10.50088949
137HCK0.49496656
138CDC42BPA0.48514570
139RPS6KA60.48434672
140SYK0.48287551
141GRK50.47974668
142MAP3K50.47875045
143MTOR0.45324349
144PAK10.43238033
145DAPK30.42866660
146PRKAA10.42281581
147PHKG10.42069194
148PHKG20.42069194
149MAPK110.41823285
150PDGFRB0.40084867
151CAMK40.39749793
152CAMK1G0.39313544
153PRKCG0.39193322
154FYN0.38793157
155JAK30.37771778
156WNK10.37592335

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047212.97432917
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.71272061
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.68590158
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.44970915
5Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.21069746
6Lysosome_Homo sapiens_hsa041422.18285455
7Type II diabetes mellitus_Homo sapiens_hsa049301.97274204
8Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.95913751
9T cell receptor signaling pathway_Homo sapiens_hsa046601.91336434
10Allograft rejection_Homo sapiens_hsa053301.91136837
11Graft-versus-host disease_Homo sapiens_hsa053321.88154095
12Collecting duct acid secretion_Homo sapiens_hsa049661.85169291
13Nitrogen metabolism_Homo sapiens_hsa009101.82365081
14Autoimmune thyroid disease_Homo sapiens_hsa053201.81556795
15Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.64250825
16Primary immunodeficiency_Homo sapiens_hsa053401.59433784
17Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.57562761
18Insulin secretion_Homo sapiens_hsa049111.55849560
19Staphylococcus aureus infection_Homo sapiens_hsa051501.52484618
20Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.51361843
21Apoptosis_Homo sapiens_hsa042101.47919526
22mTOR signaling pathway_Homo sapiens_hsa041501.47328134
23Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.47317764
24Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.46927164
25Toll-like receptor signaling pathway_Homo sapiens_hsa046201.45577648
26Vibrio cholerae infection_Homo sapiens_hsa051101.40552009
27Olfactory transduction_Homo sapiens_hsa047401.37397586
28Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.36661482
29NF-kappa B signaling pathway_Homo sapiens_hsa040641.36577168
30Leishmaniasis_Homo sapiens_hsa051401.36539586
31Malaria_Homo sapiens_hsa051441.35741553
32SNARE interactions in vesicular transport_Homo sapiens_hsa041301.34135911
33Acute myeloid leukemia_Homo sapiens_hsa052211.32478500
34GABAergic synapse_Homo sapiens_hsa047271.31031279
35Phosphatidylinositol signaling system_Homo sapiens_hsa040701.29467248
36Glycosaminoglycan degradation_Homo sapiens_hsa005311.28235621
37Long-term potentiation_Homo sapiens_hsa047201.27786684
38Other glycan degradation_Homo sapiens_hsa005111.26329757
39Carbohydrate digestion and absorption_Homo sapiens_hsa049731.25637881
40Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.23840907
41Arginine biosynthesis_Homo sapiens_hsa002201.22780161
42Measles_Homo sapiens_hsa051621.14843081
43Insulin resistance_Homo sapiens_hsa049311.14290421
44Dopaminergic synapse_Homo sapiens_hsa047281.13888424
45Biosynthesis of amino acids_Homo sapiens_hsa012301.12963439
46Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.11881733
47Rheumatoid arthritis_Homo sapiens_hsa053231.10426722
48Aldosterone synthesis and secretion_Homo sapiens_hsa049251.07459429
49Hematopoietic cell lineage_Homo sapiens_hsa046401.06785675
50Antigen processing and presentation_Homo sapiens_hsa046121.06719206
51Vascular smooth muscle contraction_Homo sapiens_hsa042701.05883191
52Circadian entrainment_Homo sapiens_hsa047131.05647980
53Carbon metabolism_Homo sapiens_hsa012001.01639634
54Intestinal immune network for IgA production_Homo sapiens_hsa046721.01087788
55Pertussis_Homo sapiens_hsa051331.00441198
56Amphetamine addiction_Homo sapiens_hsa050311.00341154
57Morphine addiction_Homo sapiens_hsa050320.99890777
58Maturity onset diabetes of the young_Homo sapiens_hsa049500.99496448
59Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.99371179
60Glioma_Homo sapiens_hsa052140.99322016
61Sphingolipid signaling pathway_Homo sapiens_hsa040710.98223361
62Jak-STAT signaling pathway_Homo sapiens_hsa046300.98109725
63Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.97438276
64Asthma_Homo sapiens_hsa053100.97308218
65Adipocytokine signaling pathway_Homo sapiens_hsa049200.96261362
66Insulin signaling pathway_Homo sapiens_hsa049100.94528579
67Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.93992645
68TNF signaling pathway_Homo sapiens_hsa046680.92392609
69Neurotrophin signaling pathway_Homo sapiens_hsa047220.92184248
70Salivary secretion_Homo sapiens_hsa049700.91850716
71Hepatitis B_Homo sapiens_hsa051610.90671099
72Gastric acid secretion_Homo sapiens_hsa049710.90202283
73Cholinergic synapse_Homo sapiens_hsa047250.90103160
74Influenza A_Homo sapiens_hsa051640.89601060
75Fructose and mannose metabolism_Homo sapiens_hsa000510.89573657
76Toxoplasmosis_Homo sapiens_hsa051450.89439253
77Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.89331572
78Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.88836126
79Bile secretion_Homo sapiens_hsa049760.88170660
80Glucagon signaling pathway_Homo sapiens_hsa049220.87894298
81Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.87039464
82Estrogen signaling pathway_Homo sapiens_hsa049150.85783953
83Systemic lupus erythematosus_Homo sapiens_hsa053220.85584400
84Fatty acid metabolism_Homo sapiens_hsa012120.85166091
85Herpes simplex infection_Homo sapiens_hsa051680.84713304
86Inositol phosphate metabolism_Homo sapiens_hsa005620.82915079
87Central carbon metabolism in cancer_Homo sapiens_hsa052300.82325283
88RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.81871644
89Renin secretion_Homo sapiens_hsa049240.81395690
90NOD-like receptor signaling pathway_Homo sapiens_hsa046210.81228678
91Cocaine addiction_Homo sapiens_hsa050300.81125106
92Chemokine signaling pathway_Homo sapiens_hsa040620.78335372
93Pyruvate metabolism_Homo sapiens_hsa006200.77828649
94Platelet activation_Homo sapiens_hsa046110.77637576
95FoxO signaling pathway_Homo sapiens_hsa040680.77586786
96Endocytosis_Homo sapiens_hsa041440.76673880
97Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.76366309
98Thyroid hormone signaling pathway_Homo sapiens_hsa049190.76247543
99Non-small cell lung cancer_Homo sapiens_hsa052230.74992838
100Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.74446496
101Fatty acid degradation_Homo sapiens_hsa000710.73528805
102Glycerolipid metabolism_Homo sapiens_hsa005610.73373299
103Galactose metabolism_Homo sapiens_hsa000520.71947902
104Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.71890698
105Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.71739698
106Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.71686615
107Glycerophospholipid metabolism_Homo sapiens_hsa005640.71526453
108Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.70953781
109Prion diseases_Homo sapiens_hsa050200.70935723
110Legionellosis_Homo sapiens_hsa051340.70764193
111Longevity regulating pathway - mammal_Homo sapiens_hsa042110.70392710
112Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.69594968
113AMPK signaling pathway_Homo sapiens_hsa041520.69029542
114VEGF signaling pathway_Homo sapiens_hsa043700.67933857
115B cell receptor signaling pathway_Homo sapiens_hsa046620.67507384
116Taste transduction_Homo sapiens_hsa047420.67249154
117Hepatitis C_Homo sapiens_hsa051600.65016628
118Regulation of autophagy_Homo sapiens_hsa041400.64587681
119Dorso-ventral axis formation_Homo sapiens_hsa043200.64408590
120Calcium signaling pathway_Homo sapiens_hsa040200.64350380
121MAPK signaling pathway_Homo sapiens_hsa040100.62927753
122Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.62744745
123Glutamatergic synapse_Homo sapiens_hsa047240.62190228
124ABC transporters_Homo sapiens_hsa020100.61792182
125Tuberculosis_Homo sapiens_hsa051520.61747004
126Circadian rhythm_Homo sapiens_hsa047100.60531721
127Osteoclast differentiation_Homo sapiens_hsa043800.59209686
128Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.59079748
129Nicotine addiction_Homo sapiens_hsa050330.58695963
130Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.58301846
131Phagosome_Homo sapiens_hsa041450.55662684
132Phospholipase D signaling pathway_Homo sapiens_hsa040720.55396917
133Oxytocin signaling pathway_Homo sapiens_hsa049210.54963351
134PPAR signaling pathway_Homo sapiens_hsa033200.54562879
135Fatty acid biosynthesis_Homo sapiens_hsa000610.54239726
136Viral myocarditis_Homo sapiens_hsa054160.54022743
137Butanoate metabolism_Homo sapiens_hsa006500.53645282
138Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.53525169
139GnRH signaling pathway_Homo sapiens_hsa049120.53256388
140Transcriptional misregulation in cancer_Homo sapiens_hsa052020.53095443
141Thyroid hormone synthesis_Homo sapiens_hsa049180.52725502
142Endometrial cancer_Homo sapiens_hsa052130.51832481
143Gap junction_Homo sapiens_hsa045400.51581044
144Alcoholism_Homo sapiens_hsa050340.51221789
145Pentose phosphate pathway_Homo sapiens_hsa000300.50391611
146Pancreatic cancer_Homo sapiens_hsa052120.50141476
147cGMP-PKG signaling pathway_Homo sapiens_hsa040220.50069658
148Selenocompound metabolism_Homo sapiens_hsa004500.49573798
149Type I diabetes mellitus_Homo sapiens_hsa049400.49381320
150Choline metabolism in cancer_Homo sapiens_hsa052310.49114316
151Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.48060913
152Prolactin signaling pathway_Homo sapiens_hsa049170.43298827

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