VPS13A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene may control steps in the cycling of proteins through the trans-Golgi network to endosomes, lysosomes and the plasma membrane. Mutations in this gene cause the autosomal recessive disorder, chorea-acanthocytosis. Alternative splicing of this gene results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)7.41491290
2nuclear pore organization (GO:0006999)6.03665393
3mitotic sister chromatid cohesion (GO:0007064)6.01807848
4monoubiquitinated protein deubiquitination (GO:0035520)5.48216102
5pore complex assembly (GO:0046931)5.40881308
6interkinetic nuclear migration (GO:0022027)5.31114887
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.10907535
8cilium or flagellum-dependent cell motility (GO:0001539)5.09190151
9acrosome assembly (GO:0001675)4.55354748
10piRNA metabolic process (GO:0034587)4.53943040
11male meiosis (GO:0007140)4.07514968
12positive regulation of gamma-delta T cell activation (GO:0046645)3.96619243
13cytoplasmic mRNA processing body assembly (GO:0033962)3.95310202
14sister chromatid cohesion (GO:0007062)3.87812098
15regulation of DNA endoreduplication (GO:0032875)3.86451322
16positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.82952747
17regulation of histone H3-K9 methylation (GO:0051570)3.82375491
18regulation of protein polyubiquitination (GO:1902914)3.79179764
19fusion of sperm to egg plasma membrane (GO:0007342)3.73835356
20positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.73789317
21positive regulation of mitotic sister chromatid separation (GO:1901970)3.73789317
22positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.73789317
23establishment of protein localization to Golgi (GO:0072600)3.68632951
24nucleus localization (GO:0051647)3.67304182
25negative regulation of fibroblast apoptotic process (GO:2000270)3.65871228
26regulation of pigment cell differentiation (GO:0050932)3.62097325
27synaptonemal complex assembly (GO:0007130)3.60526096
28synaptonemal complex organization (GO:0070193)3.54887899
29pre-miRNA processing (GO:0031054)3.51955999
30gene silencing by RNA (GO:0031047)3.50984751
31retrograde transport, vesicle recycling within Golgi (GO:0000301)3.50515216
32lipid translocation (GO:0034204)3.48451767
33phospholipid translocation (GO:0045332)3.48451767
34negative regulation of DNA repair (GO:0045738)3.46908919
35regulation of RNA export from nucleus (GO:0046831)3.46699189
36mitotic chromosome condensation (GO:0007076)3.45039155
37bundle of His cell to Purkinje myocyte communication (GO:0086069)3.41624489
38negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.41040194
39negative regulation of cell killing (GO:0031342)3.41040194
40positive regulation of histone deacetylation (GO:0031065)3.40440638
41cell-cell recognition (GO:0009988)3.40387787
42centrosome duplication (GO:0051298)3.38470474
43multicellular organism reproduction (GO:0032504)3.38445719
44sperm-egg recognition (GO:0035036)3.34642294
45histone-serine phosphorylation (GO:0035404)3.33334288
46protein prenylation (GO:0018342)3.32858247
47prenylation (GO:0097354)3.32858247
48regulation of histone H3-K27 methylation (GO:0061085)3.32742994
49negative regulation of histone methylation (GO:0031061)3.32594670
50regulation of nucleobase-containing compound transport (GO:0032239)3.28929653
51antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.28769840
52antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.28769840
53regulation of centriole replication (GO:0046599)3.27643604
54epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.26805905
55sperm motility (GO:0030317)3.25094450
56peptidyl-lysine dimethylation (GO:0018027)3.24739500
57definitive hemopoiesis (GO:0060216)3.18649354
58histone H3-K4 trimethylation (GO:0080182)3.17003341
59protein targeting to Golgi (GO:0000042)3.16177978
60DNA geometric change (GO:0032392)3.10626291
61negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.10438804
62antigen processing and presentation of endogenous antigen (GO:0019883)3.08672300
63DNA duplex unwinding (GO:0032508)3.08498699
64protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)3.04155968
65negative regulation of neurotransmitter secretion (GO:0046929)3.03768435
66binding of sperm to zona pellucida (GO:0007339)3.02771958
67regulation of establishment or maintenance of cell polarity (GO:0032878)3.02448589
68embryonic retina morphogenesis in camera-type eye (GO:0060059)3.02123747
69cell wall macromolecule catabolic process (GO:0016998)3.01011092
70cell wall macromolecule metabolic process (GO:0044036)3.01011092
71regulation of gamma-delta T cell differentiation (GO:0045586)3.00800297
72NLS-bearing protein import into nucleus (GO:0006607)2.97313025
73myofibril assembly (GO:0030239)2.95852973
74peptidyl-lysine trimethylation (GO:0018023)2.91162940
75plasma membrane fusion (GO:0045026)2.90254939
76negative T cell selection (GO:0043383)2.89917682
77histone H3-K9 methylation (GO:0051567)2.89246487
78positive regulation of mRNA catabolic process (GO:0061014)2.88913972
79gene silencing (GO:0016458)2.88179980
80protein K48-linked deubiquitination (GO:0071108)2.87625575
81chromosome organization involved in meiosis (GO:0070192)2.87451081
82regulation of centrosome duplication (GO:0010824)2.86890015
83regulation of mRNA catabolic process (GO:0061013)2.86693928
84genitalia morphogenesis (GO:0035112)2.86199394
85N-terminal protein amino acid acetylation (GO:0006474)2.85843094
86DNA methylation involved in gamete generation (GO:0043046)2.85753477
87cellular response to ethanol (GO:0071361)2.85191032
88negative thymic T cell selection (GO:0045060)2.83831807
89translesion synthesis (GO:0019985)2.83605971
90DNA unwinding involved in DNA replication (GO:0006268)2.83409855
91DNA synthesis involved in DNA repair (GO:0000731)2.83165935
92chromatin assembly (GO:0031497)2.83054779
93spermatid development (GO:0007286)2.81999064
94macroautophagy (GO:0016236)2.81747596
95negative regulation of translation, ncRNA-mediated (GO:0040033)2.80799987
96regulation of translation, ncRNA-mediated (GO:0045974)2.80799987
97negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.80799987
98histone H3-K36 demethylation (GO:0070544)2.79050232
99regulation of transforming growth factor beta2 production (GO:0032909)2.77690379
100negative regulation of potassium ion transmembrane transport (GO:1901380)2.76725246
101carnitine shuttle (GO:0006853)2.76426529
102regulation of sister chromatid cohesion (GO:0007063)2.75069018
103regulation of gamma-delta T cell activation (GO:0046643)2.74979704
104peptidyl-threonine phosphorylation (GO:0018107)2.74212424
105positive regulation of developmental pigmentation (GO:0048087)2.72646296
106peptidyl-threonine modification (GO:0018210)2.72345753
107nucleus organization (GO:0006997)2.69361390
108positive thymic T cell selection (GO:0045059)2.67762266
109corticosteroid receptor signaling pathway (GO:0031958)2.67344447
110regulation of interleukin-12 biosynthetic process (GO:0045075)2.67297204
111growth hormone receptor signaling pathway (GO:0060396)2.65454828
112reproduction (GO:0000003)2.65167481
113regulation of spindle organization (GO:0090224)2.64248220
114peptidyl-lysine methylation (GO:0018022)2.63707484
115DNA conformation change (GO:0071103)2.63641516
116meiotic cell cycle (GO:0051321)2.63437984
117negative regulation of histone modification (GO:0031057)2.62785441
118meiotic chromosome segregation (GO:0045132)2.62633517
119positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.62221853
120regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.62221853
121phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.62013542
122protein localization to chromosome, centromeric region (GO:0071459)2.61797418
123regulation of establishment of cell polarity (GO:2000114)2.61765826
124COPII vesicle coating (GO:0048208)2.61476487
125histone mRNA catabolic process (GO:0071044)2.61334441
126iron ion import (GO:0097286)2.61278858
127positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.60109083
128histone H3-K9 demethylation (GO:0033169)2.58390654
129DNA packaging (GO:0006323)2.57712119
130positive T cell selection (GO:0043368)2.57502440
131positive regulation of DNA-templated transcription, initiation (GO:2000144)2.57478845
132cardiac myofibril assembly (GO:0055003)2.57472037
133histone phosphorylation (GO:0016572)2.55281024
134meiotic nuclear division (GO:0007126)2.55252298
135histone H3-K9 modification (GO:0061647)2.55119060
136cardiac muscle hypertrophy (GO:0003300)2.54693379
137sister chromatid segregation (GO:0000819)2.54036030
138pericardium development (GO:0060039)2.54012580
139chromosome condensation (GO:0030261)2.53123252
140regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.50088286
141mRNA modification (GO:0016556)2.49450518
142carnitine transmembrane transport (GO:1902603)2.49314635
143amino-acid betaine transport (GO:0015838)2.48478998
144carnitine transport (GO:0015879)2.48478998
145snRNA transcription (GO:0009301)2.48330358
146histone lysine methylation (GO:0034968)2.48054319
147regulation of energy homeostasis (GO:2000505)2.47607673
148histone lysine demethylation (GO:0070076)2.43973715
149embryonic camera-type eye morphogenesis (GO:0048596)2.41999622
150skeletal muscle adaptation (GO:0043501)2.41566125
151labyrinthine layer development (GO:0060711)2.40921587
152striated muscle hypertrophy (GO:0014897)2.37737852
153microtubule anchoring (GO:0034453)2.36808755
154early endosome to late endosome transport (GO:0045022)2.36195870
155regulation of centrosome cycle (GO:0046605)2.33405644
156glucocorticoid receptor signaling pathway (GO:0042921)2.33128908
157establishment of nucleus localization (GO:0040023)2.31858340
158positive regulation of glycolytic process (GO:0045821)2.31267161
159insulin-like growth factor receptor signaling pathway (GO:0048009)2.31136458

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.61286352
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.59775818
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.58297071
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.71204833
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.29244882
6SALL1_21062744_ChIP-ChIP_HESCs_Human3.27194180
7FOXM1_23109430_ChIP-Seq_U2OS_Human2.86475301
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.37582870
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.36695749
10GATA1_22025678_ChIP-Seq_K562_Human2.34130005
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.24373410
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.21324857
13CDX2_19796622_ChIP-Seq_MESCs_Mouse2.18915434
14PIAS1_25552417_ChIP-Seq_VCAP_Human2.06397733
15FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.05504022
16KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.03251347
17MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.02636884
18SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.98125822
19CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.89901433
20IGF1R_20145208_ChIP-Seq_DFB_Human1.83432458
21IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.82246070
22E2F4_17652178_ChIP-ChIP_JURKAT_Human1.81477759
23SMAD_19615063_ChIP-ChIP_OVARY_Human1.80277803
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.80257356
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.78428104
26PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.77389133
27RUNX_20019798_ChIP-Seq_JUKART_Human1.75812793
28TP53_16413492_ChIP-PET_HCT116_Human1.70074932
29AR_21572438_ChIP-Seq_LNCaP_Human1.69572447
30RBPJ_22232070_ChIP-Seq_NCS_Mouse1.68619472
31FLI1_27457419_Chip-Seq_LIVER_Mouse1.66340247
32EWS_26573619_Chip-Seq_HEK293_Human1.60246799
33* AR_21909140_ChIP-Seq_LNCAP_Human1.58830883
34MYB_26560356_Chip-Seq_TH1_Human1.56182181
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.53665211
36SCL_19346495_ChIP-Seq_HPC-7_Human1.52380833
37AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.52017326
38ZFP57_27257070_Chip-Seq_ESCs_Mouse1.51980022
39MYC_22102868_ChIP-Seq_BL_Human1.51594689
40IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.51396935
41POU3F2_20337985_ChIP-ChIP_501MEL_Human1.50422216
42ER_23166858_ChIP-Seq_MCF-7_Human1.49103075
43MYB_26560356_Chip-Seq_TH2_Human1.42267287
44AHR_22903824_ChIP-Seq_MCF-7_Human1.41790292
45EP300_21415370_ChIP-Seq_HL-1_Mouse1.41272152
46Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.40630800
47OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40008692
48TCF7_22412390_ChIP-Seq_EML_Mouse1.39331155
49P300_19829295_ChIP-Seq_ESCs_Human1.38213535
50PCGF2_27294783_Chip-Seq_ESCs_Mouse1.38020998
51CTNNB1_20460455_ChIP-Seq_HCT116_Human1.35962152
52ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.35933649
53FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.35854351
54VDR_22108803_ChIP-Seq_LS180_Human1.33950677
55* E2F1_21310950_ChIP-Seq_MCF-7_Human1.30153321
56SALL4_18804426_ChIP-ChIP_XEN_Mouse1.29078415
57RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28792678
58TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.27966782
59ESR1_20079471_ChIP-ChIP_T-47D_Human1.27218551
60SMAD3_21741376_ChIP-Seq_EPCs_Human1.26819602
61* STAT3_23295773_ChIP-Seq_U87_Human1.24248276
62MYB_21317192_ChIP-Seq_ERMYB_Mouse1.23514696
63ZNF217_24962896_ChIP-Seq_MCF-7_Human1.22858110
64* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.22791528
65* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.22791528
66KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.21849033
67UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21110274
68ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.20886557
69PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.20252609
70EZH2_22144423_ChIP-Seq_EOC_Human1.18766903
71TCF4_23295773_ChIP-Seq_U87_Human1.18640251
72NANOG_18555785_Chip-Seq_ESCs_Mouse1.18397222
73* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.18112837
74* IRF8_27001747_Chip-Seq_BMDM_Mouse1.17992110
75* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.16734461
76STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.16433839
77SMAD4_21799915_ChIP-Seq_A2780_Human1.16026328
78BCAT_22108803_ChIP-Seq_LS180_Human1.15721332
79MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.15599664
80PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.15299677
81NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.14279419
82PCGF2_27294783_Chip-Seq_NPCs_Mouse1.13789709
83TCF4_18268006_ChIP-ChIP_LS174T_Human1.13488880
84CTBP2_25329375_ChIP-Seq_LNCAP_Human1.12997093
85SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12970793
86FOXO3_23340844_ChIP-Seq_DLD1_Human1.12518305
87NR3C1_21868756_ChIP-Seq_MCF10A_Human1.11739834
88GATA3_27048872_Chip-Seq_THYMUS_Human1.10460942
89* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.10335405
90TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09848959
91FUS_26573619_Chip-Seq_HEK293_Human1.09833376
92TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09706302
93YAP1_20516196_ChIP-Seq_MESCs_Mouse1.09705633
94NFE2_27457419_Chip-Seq_LIVER_Mouse1.09594187
95TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.09589027
96FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.09545500
97SUZ12_18555785_Chip-Seq_ESCs_Mouse1.09516865
98SOX2_21211035_ChIP-Seq_LN229_Gbm1.09092059
99FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.08183430
100OCT4_21477851_ChIP-Seq_ESCs_Mouse1.06913249
101SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.06246119
102NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.05808081
103* TP63_23658742_ChIP-Seq_EP156T_Human1.05537954
104CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.05513360
105IRF8_21731497_ChIP-ChIP_J774_Mouse1.05313916
106FOXA1_25552417_ChIP-Seq_VCAP_Human1.05104139
107* CBP_20019798_ChIP-Seq_JUKART_Human1.04959252
108* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.04959252
109PPAR_26484153_Chip-Seq_NCI-H1993_Human1.04797611
110SUZ12_27294783_Chip-Seq_NPCs_Mouse1.03836308
111TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.03496905
112AR_25329375_ChIP-Seq_VCAP_Human1.03330003
113E2F1_18555785_Chip-Seq_ESCs_Mouse1.02816271
114* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.02243105
115SPI1_23127762_ChIP-Seq_K562_Human1.01644447
116FOXM1_26456572_ChIP-Seq_MCF-7_Human1.01575640
117CDX2_22108803_ChIP-Seq_LS180_Human1.01190707
118EZH2_27294783_Chip-Seq_NPCs_Mouse1.01082725
119MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.99458906
120P53_22387025_ChIP-Seq_ESCs_Mouse0.98019093
121* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.97307287
122EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.95792357
123CMYC_18555785_Chip-Seq_ESCs_Mouse0.95618343
124CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.95423599
125ZNF274_21170338_ChIP-Seq_K562_Hela0.94340018
126UTX_26944678_Chip-Seq_JUKART_Human0.94316139
127HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.93476109
128ARNT_22903824_ChIP-Seq_MCF-7_Human0.93268066
129* RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.93252303
130SMRT_27268052_Chip-Seq_Bcells_Human0.93126059
131FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.92757986
132BRD4_25478319_ChIP-Seq_HGPS_Human0.92550273
133OCT4_18555785_Chip-Seq_ESCs_Mouse0.92449214
134TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92421151
135POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.92421151
136TAF15_26573619_Chip-Seq_HEK293_Human0.92253001
137STAT6_21828071_ChIP-Seq_BEAS2B_Human0.91750852
138TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.90386694
139PU_27001747_Chip-Seq_BMDM_Mouse0.89771862
140GBX2_23144817_ChIP-Seq_PC3_Human0.88863657
141* FOXA2_19822575_ChIP-Seq_HepG2_Human0.88741407
142* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.88362707
143* PKCTHETA_26484144_Chip-Seq_BREAST_Human0.88307561
144ETS1_22383799_ChIP-Seq_G1ME_Mouse0.88274239
145VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.88199437
146FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.87647616
147BRD4_27068464_Chip-Seq_AML-cells_Mouse0.87353160

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation5.28262316
2MP0008877_abnormal_DNA_methylation4.56450995
3MP0003300_gastrointestinal_ulcer3.36490862
4MP0002166_altered_tumor_susceptibility3.16718371
5MP0005410_abnormal_fertilization3.14329367
6MP0003787_abnormal_imprinting3.13286418
7MP0004145_abnormal_muscle_electrophysio3.01548200
8MP0008057_abnormal_DNA_replication2.87054641
9MP0002009_preneoplasia2.66813995
10MP0004084_abnormal_cardiac_muscle2.61344878
11MP0010307_abnormal_tumor_latency2.57920762
12MP0002396_abnormal_hematopoietic_system2.57760272
13MP0010234_abnormal_vibrissa_follicle2.55664084
14MP0003763_abnormal_thymus_physiology2.54527280
15MP0002006_tumorigenesis2.51574676
16MP0003646_muscle_fatigue2.50413349
17MP0004808_abnormal_hematopoietic_stem2.49603395
18MP0003950_abnormal_plasma_membrane2.45112650
19MP0010094_abnormal_chromosome_stability2.44822724
20MP0004036_abnormal_muscle_relaxation2.35880515
21MP0002877_abnormal_melanocyte_morpholog2.35319644
22MP0010352_gastrointestinal_tract_polyps2.32056133
23MP0001661_extended_life_span2.17326469
24MP0005409_darkened_coat_color2.07912669
25MP0003183_abnormal_peptide_metabolism2.04875912
26MP0001835_abnormal_antigen_presentation2.04717537
27MP0003045_fibrosis2.01046237
28MP0009697_abnormal_copulation2.00123233
29MP0001929_abnormal_gametogenesis1.90711247
30MP0005076_abnormal_cell_differentiation1.85525238
31MP0000685_abnormal_immune_system1.71279280
32MP0001873_stomach_inflammation1.67183587
33MP0002398_abnormal_bone_marrow1.64630414
34MP0003698_abnormal_male_reproductive1.62661298
35MP0004510_myositis1.61257696
36MP0000703_abnormal_thymus_morphology1.57082776
37MP0004215_abnormal_myocardial_fiber1.56699602
38MP0004264_abnormal_extraembryonic_tissu1.56083410
39MP0001800_abnormal_humoral_immune1.54457696
40MP0003941_abnormal_skin_development1.54234176
41MP0003868_abnormal_feces_composition1.49532981
42MP0005451_abnormal_body_composition1.49511860
43MP0003077_abnormal_cell_cycle1.48522108
44MP0003252_abnormal_bile_duct1.41545603
45MP0005670_abnormal_white_adipose1.40690980
46MP0008961_abnormal_basal_metabolism1.39569139
47MP0003111_abnormal_nucleus_morphology1.39464862
48MP0004185_abnormal_adipocyte_glucose1.38363300
49MP0000427_abnormal_hair_cycle1.34748907
50MP0003705_abnormal_hypodermis_morpholog1.34620342
51MP0003091_abnormal_cell_migration1.33810490
52MP0001666_abnormal_nutrient_absorption1.32561245
53MP0005310_abnormal_salivary_gland1.30704619
54MP0003656_abnormal_erythrocyte_physiolo1.28985013
55MP0002210_abnormal_sex_determination1.28305650
56MP0005666_abnormal_adipose_tissue1.25071845
57MP0003943_abnormal_hepatobiliary_system1.24996842
58MP0001915_intracranial_hemorrhage1.24382563
59MP0004087_abnormal_muscle_fiber1.22698869
60MP0002269_muscular_atrophy1.22367604
61MP0002928_abnormal_bile_duct1.21494112
62MP0006138_congestive_heart_failure1.21114935
63MP0005464_abnormal_platelet_physiology1.20720073
64MP0008058_abnormal_DNA_repair1.20046994
65MP0000716_abnormal_immune_system1.19672166
66MP0002452_abnormal_antigen_presenting1.17679864
67MP0002420_abnormal_adaptive_immunity1.17338673
68* MP0005397_hematopoietic_system_phenotyp1.16629616
69* MP0001545_abnormal_hematopoietic_system1.16629616
70MP0010630_abnormal_cardiac_muscle1.15465636
71MP0008775_abnormal_heart_ventricle1.15374742
72MP0008007_abnormal_cellular_replicative1.15257273
73MP0001819_abnormal_immune_cell1.14857179
74MP0001790_abnormal_immune_system1.14239463
75MP0005387_immune_system_phenotype1.14239463
76MP0004484_altered_response_of1.12902070
77MP0000689_abnormal_spleen_morphology1.11753220
78MP0005220_abnormal_exocrine_pancreas1.11017363
79MP0005671_abnormal_response_to1.10762629
80MP0004134_abnormal_chest_morphology1.09569608
81MP0002722_abnormal_immune_system1.08329304
82MP0002723_abnormal_immune_serum1.05750815
83MP0010678_abnormal_skin_adnexa1.05535332
84MP0004957_abnormal_blastocyst_morpholog1.04842464
85MP0004130_abnormal_muscle_cell1.04170059
86MP0004233_abnormal_muscle_weight1.03663831
87MP0006054_spinal_hemorrhage1.02901863
88MP0001145_abnormal_male_reproductive1.02384401
89MP0002837_dystrophic_cardiac_calcinosis1.01423084
90MP0001730_embryonic_growth_arrest1.00009549
91MP0002106_abnormal_muscle_physiology0.99722350
92MP0009780_abnormal_chondrocyte_physiolo0.98955184
93MP0002254_reproductive_system_inflammat0.98697219
94MP0010155_abnormal_intestine_physiology0.98210120
95MP0000653_abnormal_sex_gland0.97908792
96MP0002086_abnormal_extraembryonic_tissu0.96445680
97MP0004197_abnormal_fetal_growth/weight/0.96300433
98MP0003890_abnormal_embryonic-extraembry0.95647411
99* MP0002429_abnormal_blood_cell0.94988702
100MP0002161_abnormal_fertility/fecundity0.94693019
101MP0010368_abnormal_lymphatic_system0.94610229
102MP0000371_diluted_coat_color0.93854464
103MP0001697_abnormal_embryo_size0.92800439
104MP0005330_cardiomyopathy0.89816796
105MP0005187_abnormal_penis_morphology0.89709265
106MP0000749_muscle_degeneration0.89143558
107MP0009703_decreased_birth_body0.89028539
108MP0000013_abnormal_adipose_tissue0.88091760
109MP0004859_abnormal_synaptic_plasticity0.87832273
110MP0003937_abnormal_limbs/digits/tail_de0.86900953
111MP0000015_abnormal_ear_pigmentation0.85903217
112MP0004947_skin_inflammation0.85277722
113MP0005647_abnormal_sex_gland0.84815853
114MP0002168_other_aberrant_phenotype0.84573204
115MP0005369_muscle_phenotype0.84438987
116MP0003121_genomic_imprinting0.84355327
117MP0004147_increased_porphyrin_level0.83780887
118MP0005620_abnormal_muscle_contractility0.83420868
119MP0002108_abnormal_muscle_morphology0.83281476
120MP0002019_abnormal_tumor_incidence0.83009845
121MP0001299_abnormal_eye_distance/0.82105225
122MP0005174_abnormal_tail_pigmentation0.81978192
123MP0005085_abnormal_gallbladder_physiolo0.80773385
124MP0000383_abnormal_hair_follicle0.80362225
125MP0002925_abnormal_cardiovascular_devel0.80197372
126MP0003935_abnormal_craniofacial_develop0.79630842
127MP0003566_abnormal_cell_adhesion0.79539618
128MP0000350_abnormal_cell_proliferation0.79451922
129MP0000733_abnormal_muscle_development0.79437108
130MP0005621_abnormal_cell_physiology0.79076637
131MP0003984_embryonic_growth_retardation0.78469068
132MP0002160_abnormal_reproductive_system0.78442332
133MP0001188_hyperpigmentation0.77767734
134MP0000462_abnormal_digestive_system0.76506296
135MP0002088_abnormal_embryonic_growth/wei0.76176440
136MP0005380_embryogenesis_phenotype0.76043355
137MP0001672_abnormal_embryogenesis/_devel0.76043355
138MP0003866_abnormal_defecation0.74966657
139MP0000747_muscle_weakness0.73861664
140MP0000266_abnormal_heart_morphology0.73613019
141MP0002084_abnormal_developmental_patter0.73359223
142MP0004272_abnormal_basement_membrane0.73116326
143MP0000428_abnormal_craniofacial_morphol0.72985787
144MP0005000_abnormal_immune_tolerance0.72800010
145MP0000432_abnormal_head_morphology0.72623306
146MP0005375_adipose_tissue_phenotype0.71846100
147MP0009115_abnormal_fat_cell0.71707113
148MP0001784_abnormal_fluid_regulation0.70895826
149MP0002971_abnormal_brown_adipose0.70558853
150MP0005360_urolithiasis0.69863128
151MP0003693_abnormal_embryo_hatching0.69688912
152MP0002697_abnormal_eye_size0.69107841
153MP0002095_abnormal_skin_pigmentation0.67578079
154MP0002405_respiratory_system_inflammati0.67469430
155MP0003699_abnormal_female_reproductive0.65556998
156MP0003786_premature_aging0.61934390

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)4.48293783
2Volvulus (HP:0002580)4.29626641
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.03242270
4Absent frontal sinuses (HP:0002688)3.72297506
5Hyperkalemia (HP:0002153)3.36282292
6Absent/shortened dynein arms (HP:0200106)3.11930822
7Dynein arm defect of respiratory motile cilia (HP:0012255)3.11930822
8Right ventricular cardiomyopathy (HP:0011663)3.10735190
9Recurrent bronchitis (HP:0002837)3.08058188
10Nasal polyposis (HP:0100582)3.06945622
11Truncal obesity (HP:0001956)3.05200978
12Calf muscle hypertrophy (HP:0008981)2.97050257
13Prominent nose (HP:0000448)2.90997828
14Subaortic stenosis (HP:0001682)2.88865042
15Abnormality of the left ventricular outflow tract (HP:0011103)2.88865042
16Acute myeloid leukemia (HP:0004808)2.87070343
17Chromsome breakage (HP:0040012)2.82190014
18Dysmetric saccades (HP:0000641)2.78078398
19Macroorchidism (HP:0000053)2.78057990
20Muscle hypertrophy of the lower extremities (HP:0008968)2.76310459
21Papillary thyroid carcinoma (HP:0002895)2.73800739
22Abnormality of the lower motor neuron (HP:0002366)2.64809253
23Bronchitis (HP:0012387)2.62423396
24T lymphocytopenia (HP:0005403)2.61496283
25Abnormality of the nasal septum (HP:0000419)2.58291842
26Flat acetabular roof (HP:0003180)2.56722045
27Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.55926146
28Heterotopia (HP:0002282)2.49026308
29Sandal gap (HP:0001852)2.45021891
30Abnormality of ocular smooth pursuit (HP:0000617)2.44690789
31Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.44215041
32Abnormal biliary tract morphology (HP:0012440)2.42319494
33Abnormality of T cell number (HP:0011839)2.40056464
34Narrow palate (HP:0000189)2.37631530
35Impaired smooth pursuit (HP:0007772)2.35053310
36Abnormality of the nasal mucosa (HP:0000433)2.32458725
37Fair hair (HP:0002286)2.31397667
38Menstrual irregularities (HP:0000858)2.28943220
39Bronchiectasis (HP:0002110)2.26249117
40Abnormal respiratory motile cilium physiology (HP:0012261)2.24234033
41Hypobetalipoproteinemia (HP:0003563)2.23732048
42Recurrent viral infections (HP:0004429)2.22695070
43Arterial thrombosis (HP:0004420)2.21032948
44Aortic aneurysm (HP:0004942)2.20556677
45Long eyelashes (HP:0000527)2.20376891
46Neonatal hypoglycemia (HP:0001998)2.19127847
47Ectopic kidney (HP:0000086)2.18855700
48Infertility (HP:0000789)2.17753910
49Short chin (HP:0000331)2.15610259
50Recurrent sinusitis (HP:0011108)2.14729137
51Overgrowth (HP:0001548)2.13115255
52Muscle fiber inclusion bodies (HP:0100299)2.12487016
53Abnormality of chromosome stability (HP:0003220)2.12288412
54Entropion (HP:0000621)2.11752525
55Colitis (HP:0002583)2.11229928
56High pitched voice (HP:0001620)2.10926223
57Abnormal delayed hypersensitivity skin test (HP:0002963)2.10213780
58Abnormal spermatogenesis (HP:0008669)2.09644336
59Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.09397898
60Hypoplasia of the thymus (HP:0000778)2.08028484
61Rhinitis (HP:0012384)2.07281693
62Hematochezia (HP:0002573)2.06175182
63Thyroiditis (HP:0100646)2.05954232
64Urethral obstruction (HP:0000796)2.05296811
65* Acanthocytosis (HP:0001927)2.03334654
66Abnormality of the calf musculature (HP:0001430)2.03306058
67Nephroblastoma (Wilms tumor) (HP:0002667)2.01939996
68Agammaglobulinemia (HP:0004432)2.01361834
69Nemaline bodies (HP:0003798)2.01352307
70Inflammation of the large intestine (HP:0002037)2.00326257
71Gaze-evoked nystagmus (HP:0000640)2.00240981
72Bundle branch block (HP:0011710)2.00049930
73Lip pit (HP:0100267)1.99974977
74Nephronophthisis (HP:0000090)1.98181077
75Vertebral arch anomaly (HP:0008438)1.98095883
76Relative macrocephaly (HP:0004482)1.97960612
77Embryonal renal neoplasm (HP:0011794)1.96687570
78Chromosomal breakage induced by crosslinking agents (HP:0003221)1.95784920
79Recurrent otitis media (HP:0000403)1.95311223
80Cubitus valgus (HP:0002967)1.95122947
81Subacute progressive viral hepatitis (HP:0006572)1.94792935
82Recurrent fungal infections (HP:0002841)1.94367146
83Chronic bronchitis (HP:0004469)1.93971208
84Tubulointerstitial nephritis (HP:0001970)1.93817998
85Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.93760286
86Upper motor neuron abnormality (HP:0002127)1.93574338
87Curly hair (HP:0002212)1.91553623
88Neoplasm of the small intestine (HP:0100833)1.91452467
89Abnormal platelet volume (HP:0011876)1.91401039
90Abnormality of the renal medulla (HP:0100957)1.90668078
91Chronic diarrhea (HP:0002028)1.90057490
92Abnormality of the frontal sinuses (HP:0002687)1.89691759
93Impulsivity (HP:0100710)1.89177804
94Obsessive-compulsive behavior (HP:0000722)1.87581442
95Abnormality of potassium homeostasis (HP:0011042)1.87489242
96Thrombocytosis (HP:0001894)1.86918989
97Aqueductal stenosis (HP:0002410)1.85413426
98Thyroid carcinoma (HP:0002890)1.85118128
99Enlarged penis (HP:0000040)1.84873933
100Abnormality of the renal cortex (HP:0011035)1.84408896
101Facial diplegia (HP:0001349)1.84261164
102Exercise-induced myalgia (HP:0003738)1.84177995
103Cutaneous melanoma (HP:0012056)1.83998582
104Genetic anticipation (HP:0003743)1.83554835
105Dislocated radial head (HP:0003083)1.82664395
106Poikiloderma (HP:0001029)1.82438277
107Biliary tract neoplasm (HP:0100574)1.82079172
108Scanning speech (HP:0002168)1.81557773
109Abnormality of the epiphyses of the hand (HP:0005924)1.80973502
110Cystic hygroma (HP:0000476)1.80923444
111Enlarged kidneys (HP:0000105)1.80567301
112Gastrointestinal inflammation (HP:0004386)1.80471209
113Abnormality of the ischium (HP:0003174)1.80021947
114Central scotoma (HP:0000603)1.79993965
115Diastasis recti (HP:0001540)1.79745400
116Low anterior hairline (HP:0000294)1.79726378
117Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.78995681
118Renal cortical cysts (HP:0000803)1.78383584
119Chronic mucocutaneous candidiasis (HP:0002728)1.77857575
120Recurrent cutaneous fungal infections (HP:0011370)1.77857575
121Overlapping toe (HP:0001845)1.76831228
122Increased mean platelet volume (HP:0011877)1.76822067
123Conjunctival telangiectasia (HP:0000524)1.75514432
124Broad palm (HP:0001169)1.75219449
125Protruding tongue (HP:0010808)1.74470686
126Hypolipoproteinemia (HP:0010981)1.73651184
127Anal stenosis (HP:0002025)1.73529037
128Blue irides (HP:0000635)1.73457812
129Aortic regurgitation (HP:0001659)1.72296987
130Fibular hypoplasia (HP:0003038)1.72038571
131Tapered finger (HP:0001182)1.71954064
132Deep philtrum (HP:0002002)1.71585536
133Acute lymphatic leukemia (HP:0006721)1.71037447
134Thickened calvaria (HP:0002684)1.70924152
135Ventricular tachycardia (HP:0004756)1.69409622
136Gastrointestinal carcinoma (HP:0002672)1.69277974
137Malignant gastrointestinal tract tumors (HP:0006749)1.69277974
138IgA deficiency (HP:0002720)1.69051807
139Abnormal pancreas size (HP:0012094)1.68489466
140Prostate neoplasm (HP:0100787)1.67931259
141Ankyloglossia (HP:0010296)1.66945251
142Hepatoblastoma (HP:0002884)1.66641911
143Abnormality of the radial head (HP:0003995)1.66378517
144Cerebral aneurysm (HP:0004944)1.66116782
145Hypoplastic iliac wings (HP:0002866)1.65629234
146Papilledema (HP:0001085)1.65313096
147Myelodysplasia (HP:0002863)1.64879517
148Abnormality of DNA repair (HP:0003254)1.64712844
149Cafe-au-lait spot (HP:0000957)1.64692083
150Limited elbow extension (HP:0001377)1.63545244
151Azoospermia (HP:0000027)1.63528864
152Increased nuchal translucency (HP:0010880)1.63150448
153Verrucae (HP:0200043)1.63039433
154Papilloma (HP:0012740)1.63039433
155Long clavicles (HP:0000890)1.62519455
156Generalized hypopigmentation of hair (HP:0011358)1.62355456
157Limited hip movement (HP:0008800)1.61568530
158Germ cell neoplasia (HP:0100728)1.60810033
159Abnormality of chloride homeostasis (HP:0011422)1.59561497
160Rimmed vacuoles (HP:0003805)1.57404039
161Clubbing of toes (HP:0100760)1.56235803
162Impaired vibratory sensation (HP:0002495)1.56041886
163Chronic hepatic failure (HP:0100626)1.54157730
164Difficulty running (HP:0009046)1.53065437
165Hypoplastic labia majora (HP:0000059)1.52698574
166Abnormality of the astrocytes (HP:0100707)1.52330758
167Astrocytoma (HP:0009592)1.52330758
168Hyporeflexia of lower limbs (HP:0002600)1.51366672
169Thick eyebrow (HP:0000574)1.51309573

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT33.73164610
2CDK123.44143556
3OBSCN3.32816721
4PDK33.21145819
5PDK43.21145819
6FRK3.17404635
7ACVR1B2.93260443
8STK38L2.53304742
9EEF2K2.50040286
10MAP4K12.47871133
11LATS12.14207369
12CDC72.10507213
13PKN22.06619585
14JAK32.04668021
15CAMK1D1.99587599
16FGFR31.90848171
17TAOK31.79759903
18BRSK21.79706308
19CDK61.77221797
20CAMK1G1.74993057
21MST1R1.73124246
22JAK11.72613035
23STK391.72468647
24STK101.64468189
25RIPK11.59635361
26NEK21.55972138
27SCYL21.55572092
28MKNK21.54528395
29ZAK1.51326529
30NLK1.48465138
31PDK21.46442285
32CDK91.42816296
33STK31.42564299
34MAP3K131.42044215
35PNCK1.40515808
36TTN1.38996709
37BMPR1B1.32768245
38NUAK11.27970067
39CDK41.27641218
40WNK11.25846254
41TRPM71.23204325
42MELK1.22563077
43PLK41.19764522
44ERBB31.19571895
45PDK11.17953395
46TYK21.17828563
47TXK1.16905515
48STK241.14951717
49PIK3CA1.13692381
50FGFR11.12837904
51ATR1.10860071
52PIK3CG1.10283301
53FGFR21.09960045
54RET1.05835192
55PDGFRB1.05427840
56MAP3K141.05396655
57BRD41.04075641
58PTK2B1.04034959
59ATM1.02953425
60CSF1R1.02903628
61CAMKK20.98097042
62EIF2AK30.98055077
63MAP3K60.98017416
64TRIB30.97573620
65MKNK10.97239553
66MET0.95114709
67SGK30.94477586
68TTK0.93682725
69FLT30.90865664
70CHUK0.90466424
71PRKD30.88092152
72MAP3K70.86172906
73MAP3K40.85552906
74STK380.84884064
75CHEK20.83322422
76ICK0.83122250
77SGK20.82374467
78MAP3K100.80737207
79CDK30.80127752
80FER0.79289792
81MTOR0.79252358
82SGK10.78603033
83LMTK20.78329376
84CHEK10.77712886
85STK40.77629551
86TNIK0.77390564
87PDGFRA0.76970145
88NEK90.75553405
89PRKAA20.74349799
90SGK2230.73514042
91SGK4940.73514042
92JAK20.72246628
93DMPK0.71740120
94ITK0.68728399
95AURKB0.67506677
96MAP3K20.64546654
97TNK20.63619221
98OXSR10.63322935
99ZAP700.62461405
100MARK20.62103019
101RIPK40.59738368
102PRKAA10.58896762
103SIK20.58402638
104PRKCQ0.57649681
105INSRR0.57022518
106HCK0.56812184
107SYK0.56478934
108PRKCH0.56234542
109FGFR40.55713366
110WNK40.55027196
111RPS6KB10.54519459
112NTRK30.53949168
113KIT0.53447587
114PIM10.52618167
115MAPK110.52327657
116IKBKE0.51804611
117TAOK10.51795560
118PTK60.51363172
119PRKDC0.51163932
120LCK0.50384719
121TAF10.49708244
122YES10.49029084
123HIPK20.48498641
124LRRK20.47258142
125BMPR20.46481909
126CAMK40.45511463
127TEC0.45262433
128MAPK100.44535264
129TGFBR10.43876005
130CDK20.43460803
131RPS6KB20.43415611
132CAMKK10.42996462
133MAPK140.42860417
134CDK10.41432464
135CSNK1D0.41118535
136CDC42BPA0.40610106
137GSK3B0.40026841
138BMX0.39764663
139NEK60.39595595
140MAP2K40.38107796
141CDK70.35923567
142RPS6KA30.35316263
143TIE10.34037717
144WNK30.29437412
145PLK20.29230916

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053401.74567428
2Lysine degradation_Homo sapiens_hsa003101.68859049
3Dorso-ventral axis formation_Homo sapiens_hsa043201.68812454
4B cell receptor signaling pathway_Homo sapiens_hsa046621.68065687
5Non-homologous end-joining_Homo sapiens_hsa034501.63855677
6Circadian rhythm_Homo sapiens_hsa047101.63575823
7Phosphatidylinositol signaling system_Homo sapiens_hsa040701.62329037
8Systemic lupus erythematosus_Homo sapiens_hsa053221.60327133
9Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.59619338
10Type II diabetes mellitus_Homo sapiens_hsa049301.59003321
11mTOR signaling pathway_Homo sapiens_hsa041501.46156629
12T cell receptor signaling pathway_Homo sapiens_hsa046601.43685479
13Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.36634069
14Long-term potentiation_Homo sapiens_hsa047201.36001330
15Glucagon signaling pathway_Homo sapiens_hsa049221.31186202
16Small cell lung cancer_Homo sapiens_hsa052221.31132444
17Thyroid cancer_Homo sapiens_hsa052161.30374155
18Pancreatic cancer_Homo sapiens_hsa052121.29477064
19Carbohydrate digestion and absorption_Homo sapiens_hsa049731.27821812
20Antigen processing and presentation_Homo sapiens_hsa046121.27769193
21Non-small cell lung cancer_Homo sapiens_hsa052231.27270817
22Chronic myeloid leukemia_Homo sapiens_hsa052201.24816099
23Fanconi anemia pathway_Homo sapiens_hsa034601.24076597
24NF-kappa B signaling pathway_Homo sapiens_hsa040641.22616599
25Osteoclast differentiation_Homo sapiens_hsa043801.21239971
26Viral carcinogenesis_Homo sapiens_hsa052031.20476786
27Inositol phosphate metabolism_Homo sapiens_hsa005621.17716981
28Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.17577180
29Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.15398387
30TGF-beta signaling pathway_Homo sapiens_hsa043501.13789293
31Cell cycle_Homo sapiens_hsa041101.13282054
32Toxoplasmosis_Homo sapiens_hsa051451.12828535
33Dilated cardiomyopathy_Homo sapiens_hsa054141.12498741
34Renin secretion_Homo sapiens_hsa049241.12054379
35MicroRNAs in cancer_Homo sapiens_hsa052061.11892529
36Maturity onset diabetes of the young_Homo sapiens_hsa049501.11780137
37Measles_Homo sapiens_hsa051621.11711025
38Thyroid hormone signaling pathway_Homo sapiens_hsa049191.11084152
39Pancreatic secretion_Homo sapiens_hsa049721.09425631
40Fatty acid biosynthesis_Homo sapiens_hsa000611.09386060
41Platelet activation_Homo sapiens_hsa046111.08447255
42Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.07018621
43Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.06430167
44Insulin resistance_Homo sapiens_hsa049311.05602183
45Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.05165052
46Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.05113989
47Hepatitis B_Homo sapiens_hsa051611.04878184
48Glioma_Homo sapiens_hsa052141.04080568
49Glycerophospholipid metabolism_Homo sapiens_hsa005641.02717694
50Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.02675162
51Adherens junction_Homo sapiens_hsa045201.01364214
52Vascular smooth muscle contraction_Homo sapiens_hsa042701.01342227
53ECM-receptor interaction_Homo sapiens_hsa045120.99461733
54Vitamin digestion and absorption_Homo sapiens_hsa049770.98645896
55Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.97549668
56FoxO signaling pathway_Homo sapiens_hsa040680.95517094
57Prolactin signaling pathway_Homo sapiens_hsa049170.94353512
58Protein digestion and absorption_Homo sapiens_hsa049740.94310921
59Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.94281695
60Jak-STAT signaling pathway_Homo sapiens_hsa046300.93410172
61RNA degradation_Homo sapiens_hsa030180.93217032
62Herpes simplex infection_Homo sapiens_hsa051680.92654147
63HTLV-I infection_Homo sapiens_hsa051660.92558034
64Oocyte meiosis_Homo sapiens_hsa041140.92426406
65Starch and sucrose metabolism_Homo sapiens_hsa005000.90577440
66Transcriptional misregulation in cancer_Homo sapiens_hsa052020.90476842
67Glycerolipid metabolism_Homo sapiens_hsa005610.89269984
68Influenza A_Homo sapiens_hsa051640.89069728
69Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.89019526
70Estrogen signaling pathway_Homo sapiens_hsa049150.88247599
71NOD-like receptor signaling pathway_Homo sapiens_hsa046210.86541091
72Tight junction_Homo sapiens_hsa045300.86186705
73Amphetamine addiction_Homo sapiens_hsa050310.84357010
74Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.84337031
75cGMP-PKG signaling pathway_Homo sapiens_hsa040220.84318087
76Acute myeloid leukemia_Homo sapiens_hsa052210.82773433
77Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.82274186
78Choline metabolism in cancer_Homo sapiens_hsa052310.81031780
79cAMP signaling pathway_Homo sapiens_hsa040240.80977569
80TNF signaling pathway_Homo sapiens_hsa046680.80933900
81Adipocytokine signaling pathway_Homo sapiens_hsa049200.80252616
82Hematopoietic cell lineage_Homo sapiens_hsa046400.80080451
83Propanoate metabolism_Homo sapiens_hsa006400.78755655
84Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.78460510
85Endometrial cancer_Homo sapiens_hsa052130.77550434
86Arginine biosynthesis_Homo sapiens_hsa002200.77262416
87Intestinal immune network for IgA production_Homo sapiens_hsa046720.76928957
88Longevity regulating pathway - mammal_Homo sapiens_hsa042110.76870852
89Aldosterone synthesis and secretion_Homo sapiens_hsa049250.76281349
90Leishmaniasis_Homo sapiens_hsa051400.76222495
91p53 signaling pathway_Homo sapiens_hsa041150.75105463
92Oxytocin signaling pathway_Homo sapiens_hsa049210.73527042
93Colorectal cancer_Homo sapiens_hsa052100.72985262
94Prostate cancer_Homo sapiens_hsa052150.72900170
95VEGF signaling pathway_Homo sapiens_hsa043700.72333080
96AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.72209394
97Thyroid hormone synthesis_Homo sapiens_hsa049180.72194900
98mRNA surveillance pathway_Homo sapiens_hsa030150.72026213
99Chemokine signaling pathway_Homo sapiens_hsa040620.71715049
100Selenocompound metabolism_Homo sapiens_hsa004500.71654554
101AMPK signaling pathway_Homo sapiens_hsa041520.71532414
102Bile secretion_Homo sapiens_hsa049760.70590075
103Salivary secretion_Homo sapiens_hsa049700.70583962
104Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.70139915
105ABC transporters_Homo sapiens_hsa020100.69738456
106Central carbon metabolism in cancer_Homo sapiens_hsa052300.69317162
107Long-term depression_Homo sapiens_hsa047300.68496870
108Fatty acid degradation_Homo sapiens_hsa000710.68383350
109Histidine metabolism_Homo sapiens_hsa003400.67697894
110Renal cell carcinoma_Homo sapiens_hsa052110.67231577
111Circadian entrainment_Homo sapiens_hsa047130.66588796
112Renin-angiotensin system_Homo sapiens_hsa046140.66530116
113Taste transduction_Homo sapiens_hsa047420.65877630
114Leukocyte transendothelial migration_Homo sapiens_hsa046700.65825307
115Insulin signaling pathway_Homo sapiens_hsa049100.65770138
116Nitrogen metabolism_Homo sapiens_hsa009100.65121797
117Alcoholism_Homo sapiens_hsa050340.64375879
118Fat digestion and absorption_Homo sapiens_hsa049750.63995743
119Focal adhesion_Homo sapiens_hsa045100.63181970
120Neurotrophin signaling pathway_Homo sapiens_hsa047220.62830353
121MAPK signaling pathway_Homo sapiens_hsa040100.62712956
122Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.62112023
123Calcium signaling pathway_Homo sapiens_hsa040200.61108097
124Fatty acid metabolism_Homo sapiens_hsa012120.61056534
125Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.60209139
126Proteoglycans in cancer_Homo sapiens_hsa052050.59442640
127Steroid hormone biosynthesis_Homo sapiens_hsa001400.58851295
128Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.58035694
129Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.57680581
130Mineral absorption_Homo sapiens_hsa049780.57082602
131GnRH signaling pathway_Homo sapiens_hsa049120.56703696
132Pentose and glucuronate interconversions_Homo sapiens_hsa000400.55658340
133Viral myocarditis_Homo sapiens_hsa054160.55552431
134Gastric acid secretion_Homo sapiens_hsa049710.54950630
135HIF-1 signaling pathway_Homo sapiens_hsa040660.54823404
136Hippo signaling pathway_Homo sapiens_hsa043900.54524160
137ErbB signaling pathway_Homo sapiens_hsa040120.52317144
138Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.52310063
139RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.52262760
140Retinol metabolism_Homo sapiens_hsa008300.51938798
141Phospholipase D signaling pathway_Homo sapiens_hsa040720.48463936
142Melanoma_Homo sapiens_hsa052180.48277875

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