VPS13B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a potential transmembrane protein that may function in vesicle-mediated transport and sorting of proteins within the cell. This protein may play a role in the development and the function of the eye, hematological system, and central nervous system. Mutations in this gene have been associated with Cohen syndrome. Multiple splice variants encoding distinct isoforms have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.30999651
2interkinetic nuclear migration (GO:0022027)4.75906935
3positive regulation of gamma-delta T cell activation (GO:0046645)4.72639629
4protein K11-linked deubiquitination (GO:0035871)4.24656900
5cellular response to ethanol (GO:0071361)4.16231566
6protein K48-linked deubiquitination (GO:0071108)4.14162963
7regulation of pigment cell differentiation (GO:0050932)4.11428158
8neural tube formation (GO:0001841)4.10197331
9histone H3-K4 trimethylation (GO:0080182)4.02439529
10positive regulation of developmental pigmentation (GO:0048087)3.95462659
11epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.78098488
12cilium or flagellum-dependent cell motility (GO:0001539)3.72571860
13regulation of establishment of cell polarity (GO:2000114)3.66747389
14macroautophagy (GO:0016236)3.63048086
15mitotic sister chromatid cohesion (GO:0007064)3.60809651
16phospholipid homeostasis (GO:0055091)3.59957472
17negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.54634891
18negative regulation of cell killing (GO:0031342)3.54634891
19histone mRNA catabolic process (GO:0071044)3.54137683
20regulation of gamma-delta T cell differentiation (GO:0045586)3.51324908
21protein targeting to vacuole (GO:0006623)3.49289508
22protein targeting to lysosome (GO:0006622)3.49289508
23establishment of protein localization to vacuole (GO:0072666)3.49289508
24retrograde transport, vesicle recycling within Golgi (GO:0000301)3.45280161
25regulation of gamma-delta T cell activation (GO:0046643)3.45097713
26cytoplasmic mRNA processing body assembly (GO:0033962)3.41809848
27histone H3-K9 methylation (GO:0051567)3.40913379
28histone H3-K4 methylation (GO:0051568)3.36970939
29nucleus localization (GO:0051647)3.35415941
30phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.33935729
31establishment of protein localization to Golgi (GO:0072600)3.30997704
32positive regulation of histone deacetylation (GO:0031065)3.30781704
33histone H3-K36 demethylation (GO:0070544)3.24444381
34protein K63-linked deubiquitination (GO:0070536)3.23600819
35regulation of establishment or maintenance of cell polarity (GO:0032878)3.22203742
36mannose metabolic process (GO:0006013)3.17347767
37peptidyl-lysine trimethylation (GO:0018023)3.15080091
38antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.14324011
39antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.14324011
40protein localization to Golgi apparatus (GO:0034067)3.12784496
41nuclear pore complex assembly (GO:0051292)3.09309813
42histone H3-K9 modification (GO:0061647)3.06946709
43protein targeting to Golgi (GO:0000042)3.06706085
44positive regulation of granulocyte differentiation (GO:0030854)3.02566822
45rRNA catabolic process (GO:0016075)2.96066430
46positive regulation of B cell differentiation (GO:0045579)2.95967690
47regulation of B cell receptor signaling pathway (GO:0050855)2.95436476
48regulation of interferon-beta biosynthetic process (GO:0045357)2.94905270
49snRNA transcription (GO:0009301)2.91991679
50hepatocyte apoptotic process (GO:0097284)2.90006985
51regulation of protein polyubiquitination (GO:1902914)2.89470155
52antigen processing and presentation of endogenous antigen (GO:0019883)2.88821876
53positive thymic T cell selection (GO:0045059)2.87553331
54regulation of ARF protein signal transduction (GO:0032012)2.86099778
55microtubule anchoring (GO:0034453)2.83623988
56regulation of DNA endoreduplication (GO:0032875)2.83020506
57negative regulation of granulocyte differentiation (GO:0030853)2.82854604
58embryonic hemopoiesis (GO:0035162)2.81948054
59lipoprotein transport (GO:0042953)2.81550202
60early endosome to late endosome transport (GO:0045022)2.79058778
61negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.77508173
62negative regulation of translation, ncRNA-mediated (GO:0040033)2.77508173
63regulation of translation, ncRNA-mediated (GO:0045974)2.77508173
64pericardium development (GO:0060039)2.76361128
65negative regulation of neurotransmitter transport (GO:0051589)2.75276410
66growth hormone receptor signaling pathway (GO:0060396)2.74141799
67insulin-like growth factor receptor signaling pathway (GO:0048009)2.72646538
68regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.71651396
69positive regulation by organism of defense response of other organism involved in symbiotic interact2.71380717
70modulation by symbiont of host immune response (GO:0052553)2.71380717
71positive regulation by symbiont of host defense response (GO:0052509)2.71380717
72modulation by symbiont of host defense response (GO:0052031)2.71380717
73modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.71380717
74modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.71380717
75lipid translocation (GO:0034204)2.70391227
76phospholipid translocation (GO:0045332)2.70391227
77B cell receptor signaling pathway (GO:0050853)2.69118734
78positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.69003696
79histone lysine methylation (GO:0034968)2.68822397
80regulation of mRNA catabolic process (GO:0061013)2.68595525
81histone H3-K9 demethylation (GO:0033169)2.67917017
82interleukin-6-mediated signaling pathway (GO:0070102)2.67718556
83I-kappaB phosphorylation (GO:0007252)2.66837732
84negative regulation of cytosolic calcium ion concentration (GO:0051481)2.66616212
85iron ion import (GO:0097286)2.64253072
86regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.63413297
87NLS-bearing protein import into nucleus (GO:0006607)2.61847177
88intra-Golgi vesicle-mediated transport (GO:0006891)2.59537788
89regulation of hippo signaling (GO:0035330)2.57189790
90striated muscle atrophy (GO:0014891)2.57008912
91regulation of interleukin-12 biosynthetic process (GO:0045075)2.55592134
92positive T cell selection (GO:0043368)2.55564002
93positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.55313085
94regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.55313085
95monoubiquitinated protein deubiquitination (GO:0035520)2.53846183
96activated T cell proliferation (GO:0050798)2.52485293
97prenylation (GO:0097354)2.52242137
98protein prenylation (GO:0018342)2.52242137
99dosage compensation (GO:0007549)2.50705351
100dicarboxylic acid biosynthetic process (GO:0043650)2.50437373
101Golgi to endosome transport (GO:0006895)2.49115980
102replicative senescence (GO:0090399)2.48731335
103embryonic retina morphogenesis in camera-type eye (GO:0060059)2.48190512
104positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.46734676
105regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.46734676
106peptidyl-lysine methylation (GO:0018022)2.46453794
107JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.43851644
108negative thymic T cell selection (GO:0045060)2.43127657
109regulation of fatty acid beta-oxidation (GO:0031998)2.42636577
110negative T cell selection (GO:0043383)2.40374681
111negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.40127132
112pore complex assembly (GO:0046931)2.39993438
113cilium movement (GO:0003341)2.39753460
114phosphatidylinositol dephosphorylation (GO:0046856)2.39526465
115regulation of B cell differentiation (GO:0045577)2.38378385
116B cell homeostasis (GO:0001782)2.38266836
117stress granule assembly (GO:0034063)2.36523949
118phospholipid dephosphorylation (GO:0046839)2.35766553
119import into cell (GO:0098657)2.35744238
120cerebellar Purkinje cell differentiation (GO:0021702)2.35112291
121macrophage activation involved in immune response (GO:0002281)2.34889206
122negative regulation of cAMP-mediated signaling (GO:0043951)2.34649171
123histone lysine demethylation (GO:0070076)2.34147163
124photoreceptor cell maintenance (GO:0045494)2.34133760
125neutrophil mediated immunity (GO:0002446)2.32776307
126response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.32742796
127response to host immune response (GO:0052572)2.32742796
128regulation of RNA export from nucleus (GO:0046831)2.32624367
129response to host (GO:0075136)2.31831134
130response to host defenses (GO:0052200)2.31831134
131response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.31831134
132positive regulation of mRNA catabolic process (GO:0061014)2.30640897
133nuclear pore organization (GO:0006999)2.29691724
134central nervous system neuron axonogenesis (GO:0021955)2.29213562
135cellular response to growth hormone stimulus (GO:0071378)2.28961672
136negative regulation of neurotransmitter secretion (GO:0046929)2.28253302
137urea cycle (GO:0000050)2.28140401
138urea metabolic process (GO:0019627)2.28140401
139protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.27976627
140lipid phosphorylation (GO:0046834)2.27726390
141positive regulation of fatty acid beta-oxidation (GO:0032000)2.27548141
142phosphatidylinositol phosphorylation (GO:0046854)2.27506577
143negative regulation of systemic arterial blood pressure (GO:0003085)2.27043849
144regulation of nucleobase-containing compound transport (GO:0032239)2.27037964
145positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.26755270
146natural killer cell mediated immunity (GO:0002228)2.26222485
147natural killer cell mediated cytotoxicity (GO:0042267)2.26222485
148regulation of histone H3-K9 methylation (GO:0051570)2.25930052
149regulation of MHC class I biosynthetic process (GO:0045343)2.25466472
150positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.25340224
151skeletal muscle adaptation (GO:0043501)2.24228523
152establishment of nucleus localization (GO:0040023)2.20047822
153axoneme assembly (GO:0035082)2.19360460
154olfactory bulb development (GO:0021772)2.19221860
155regulation of protein glycosylation (GO:0060049)2.18673276
156regulation of Rab GTPase activity (GO:0032313)2.15479865
157positive regulation of Rab GTPase activity (GO:0032851)2.15479865
158muscle atrophy (GO:0014889)2.15065399
159cilium morphogenesis (GO:0060271)2.15049276
160cilium organization (GO:0044782)2.15025107
161epithelial cilium movement (GO:0003351)2.14843136
162negative regulation of sodium ion transport (GO:0010766)2.13935227
163microtubule nucleation (GO:0007020)2.13462491
164definitive hemopoiesis (GO:0060216)2.12717718
165cilium assembly (GO:0042384)2.12397129
166fucose catabolic process (GO:0019317)2.11475709
167L-fucose metabolic process (GO:0042354)2.11475709
168L-fucose catabolic process (GO:0042355)2.11475709
169oocyte development (GO:0048599)2.09207387

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.86857263
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.46240360
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.42836598
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.34091966
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.26439122
6GATA1_22025678_ChIP-Seq_K562_Human2.74510474
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.51194560
8STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.39404287
9VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.24485989
10E2F7_22180533_ChIP-Seq_HELA_Human2.22730850
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.18580980
12Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.13530491
13* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.08717436
14IGF1R_20145208_ChIP-Seq_DFB_Human2.07666535
15RUNX_20019798_ChIP-Seq_JUKART_Human2.06487501
16SCL_19346495_ChIP-Seq_HPC-7_Human2.04744087
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.04588551
18STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.04216585
19* IRF8_27001747_Chip-Seq_BMDM_Mouse2.02026388
20TAF15_26573619_Chip-Seq_HEK293_Human2.00744426
21IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.94633330
22FLI1_27457419_Chip-Seq_LIVER_Mouse1.94266626
23* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.92570195
24* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.91754217
25SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.85804234
26ZNF274_21170338_ChIP-Seq_K562_Hela1.84484150
27EGR1_19374776_ChIP-ChIP_THP-1_Human1.83993125
28PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.83293662
29NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.82953208
30ER_23166858_ChIP-Seq_MCF-7_Human1.78592766
31IRF8_21731497_ChIP-ChIP_J774_Mouse1.73960967
32RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.72061212
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.69788767
34VDR_22108803_ChIP-Seq_LS180_Human1.69390161
35AR_21572438_ChIP-Seq_LNCaP_Human1.68832936
36SPI1_23127762_ChIP-Seq_K562_Human1.68229806
37CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.68079504
38FUS_26573619_Chip-Seq_HEK293_Human1.67521825
39PCGF2_27294783_Chip-Seq_ESCs_Mouse1.63280701
40SMAD_19615063_ChIP-ChIP_OVARY_Human1.62139256
41P300_19829295_ChIP-Seq_ESCs_Human1.61599938
42MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.59907718
43EWS_26573619_Chip-Seq_HEK293_Human1.59636785
44* FOXA2_19822575_ChIP-Seq_HepG2_Human1.58570737
45CTBP2_25329375_ChIP-Seq_LNCAP_Human1.57231449
46AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.56539272
47IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.56074392
48MYB_21317192_ChIP-Seq_ERMYB_Mouse1.51483127
49CBP_20019798_ChIP-Seq_JUKART_Human1.51104369
50IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.51104369
51LXR_22158963_ChIP-Seq_LIVER_Mouse1.50216685
52SALL1_21062744_ChIP-ChIP_HESCs_Human1.49912304
53* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.49261472
54UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.46262886
55NR3C1_21868756_ChIP-Seq_MCF10A_Human1.44961373
56PCGF2_27294783_Chip-Seq_NPCs_Mouse1.43386934
57* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43140566
58NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.42756399
59TP53_16413492_ChIP-PET_HCT116_Human1.40633192
60SUZ12_27294783_Chip-Seq_NPCs_Mouse1.39881016
61TCF7_22412390_ChIP-Seq_EML_Mouse1.39402275
62ESR1_20079471_ChIP-ChIP_T-47D_Human1.38673698
63CTBP1_25329375_ChIP-Seq_LNCAP_Human1.38415962
64* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38219234
65BRD4_27068464_Chip-Seq_AML-cells_Mouse1.38076526
66FOXM1_23109430_ChIP-Seq_U2OS_Human1.36616874
67* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.36342486
68SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.35879882
69EZH2_27294783_Chip-Seq_NPCs_Mouse1.35637425
70TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35135778
71POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.35135778
72CTNNB1_20460455_ChIP-Seq_HCT116_Human1.33265296
73SMAD3_21741376_ChIP-Seq_EPCs_Human1.33049412
74AR_25329375_ChIP-Seq_VCAP_Human1.32046951
75CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.31539226
76VDR_24787735_ChIP-Seq_THP-1_Human1.30567852
77PRDM14_20953172_ChIP-Seq_ESCs_Human1.29911995
78NANOG_18555785_Chip-Seq_ESCs_Mouse1.29736703
79BCAT_22108803_ChIP-Seq_LS180_Human1.29535926
80SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29353103
81MYB_26560356_Chip-Seq_TH1_Human1.28516497
82FLI1_21867929_ChIP-Seq_TH2_Mouse1.26965671
83GATA2_21666600_ChIP-Seq_HMVEC_Human1.26707289
84EGR1_23403033_ChIP-Seq_LIVER_Mouse1.25753217
85KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.24826812
86TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24621551
87NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.23934295
88MYC_22102868_ChIP-Seq_BL_Human1.23638341
89* RUNX2_22187159_ChIP-Seq_PCA_Human1.22759522
90NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.22593921
91NRF2_20460467_ChIP-Seq_MEFs_Mouse1.22593921
92PU_27001747_Chip-Seq_BMDM_Mouse1.21471725
93EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.21304204
94ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.21227547
95MYB_26560356_Chip-Seq_TH2_Human1.21211956
96TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20620108
97GATA1_19941827_ChIP-Seq_MEL_Mouse1.20460932
98* STAT3_23295773_ChIP-Seq_U87_Human1.19878146
99CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.19804229
100EZH2_22144423_ChIP-Seq_EOC_Human1.19492686
101NFE2_27457419_Chip-Seq_LIVER_Mouse1.19228332
102ARNT_22903824_ChIP-Seq_MCF-7_Human1.16852161
103E2F1_18555785_Chip-Seq_ESCs_Mouse1.16552562
104AHR_22903824_ChIP-Seq_MCF-7_Human1.15912004
105PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.14828412
106TCF4_22108803_ChIP-Seq_LS180_Human1.14762046
107TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.14030587
108RXR_22158963_ChIP-Seq_LIVER_Mouse1.13909410
109DROSHA_22980978_ChIP-Seq_HELA_Human1.13907452
110* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13766304
111DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.13471577
112TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.13284224
113RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.12471013
114FOXO3_23340844_ChIP-Seq_DLD1_Human1.11619655
115KDM2B_26808549_Chip-Seq_REH_Human1.11538974
116* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.10654288
117BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.10427503
118CDX2_22108803_ChIP-Seq_LS180_Human1.10299385
119P53_22387025_ChIP-Seq_ESCs_Mouse1.09831903
120* TCF4_23295773_ChIP-Seq_U87_Human1.08787048
121E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.08317312
122GATA3_27048872_Chip-Seq_THYMUS_Human1.08273033
123OCT4_21477851_ChIP-Seq_ESCs_Mouse1.08167784
124GATA1_19941826_ChIP-Seq_K562_Human1.07694777
125CJUN_26792858_Chip-Seq_BT549_Human1.07688580
126GBX2_23144817_ChIP-Seq_PC3_Human1.07122475
127CDX2_19796622_ChIP-Seq_MESCs_Mouse1.06879265
128CRX_20693478_ChIP-Seq_RETINA_Mouse1.05962269
129PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05822811
130POU3F2_20337985_ChIP-ChIP_501MEL_Human1.04393960
131RXR_22108803_ChIP-Seq_LS180_Human1.04264645
132CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.04061752
133TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03712362
134CMYC_18555785_Chip-Seq_ESCs_Mouse1.03579446
135SMAD4_21799915_ChIP-Seq_A2780_Human1.03228153
136KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.02605417
137* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.02331713
138SUZ12_18555785_Chip-Seq_ESCs_Mouse1.02227369
139FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01164679
140ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.00810783
141GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.00351961
142GATA2_19941826_ChIP-Seq_K562_Human1.00341721
143PPARA_22158963_ChIP-Seq_LIVER_Mouse0.99895723
144VDR_24763502_ChIP-Seq_THP-1_Human0.96950595
145MAF_26560356_Chip-Seq_TH1_Human0.94715464
146GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93973614
147FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.92669292
148PKCTHETA_26484144_Chip-Seq_BREAST_Human0.92504826
149PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91233517
150PIAS1_25552417_ChIP-Seq_VCAP_Human0.90428974
151FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.89949452
152VDR_21846776_ChIP-Seq_THP-1_Human0.88796292
153GATA3_26560356_Chip-Seq_TH2_Human0.87403364
154KDM2B_26808549_Chip-Seq_DND41_Human0.85334158
155BRD4_25478319_ChIP-Seq_HGPS_Human0.85156535
156ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.85007765
157ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.84031209
158UTX_26944678_Chip-Seq_JUKART_Human0.83769548
159TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.83628790
160TCF4_18268006_ChIP-ChIP_LS174T_Human0.83598076
161* SOX2_21211035_ChIP-Seq_LN229_Gbm0.82782068
162AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.81994259

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation7.96182476
2MP0003300_gastrointestinal_ulcer3.36508238
3MP0002166_altered_tumor_susceptibility3.05164000
4MP0003183_abnormal_peptide_metabolism2.59496920
5MP0003172_abnormal_lysosome_physiology2.55537115
6MP0000383_abnormal_hair_follicle2.43031132
7MP0003045_fibrosis2.31256687
8MP0003252_abnormal_bile_duct2.16347010
9MP0003646_muscle_fatigue2.13075948
10MP0001835_abnormal_antigen_presentation2.12129045
11MP0005365_abnormal_bile_salt2.11666688
12MP0002006_tumorigenesis2.10394666
13MP0005174_abnormal_tail_pigmentation2.06134156
14MP0010307_abnormal_tumor_latency2.04058306
15MP0002396_abnormal_hematopoietic_system1.98103899
16MP0000371_diluted_coat_color1.96771203
17MP0005076_abnormal_cell_differentiation1.92102645
18MP0005670_abnormal_white_adipose1.86908525
19MP0004264_abnormal_extraembryonic_tissu1.84010878
20MP0010678_abnormal_skin_adnexa1.83739338
21MP0001800_abnormal_humoral_immune1.81022889
22MP0005360_urolithiasis1.79214395
23MP0002139_abnormal_hepatobiliary_system1.75835947
24MP0004808_abnormal_hematopoietic_stem1.74139777
25MP0000685_abnormal_immune_system1.71774353
26MP0002009_preneoplasia1.71515036
27MP0003868_abnormal_feces_composition1.65606208
28MP0003787_abnormal_imprinting1.64468929
29MP0003195_calcinosis1.61601467
30MP0005058_abnormal_lysosome_morphology1.58738386
31MP0004381_abnormal_hair_follicle1.58458048
32MP0003303_peritoneal_inflammation1.56650123
33MP0001790_abnormal_immune_system1.56366503
34MP0005387_immune_system_phenotype1.56366503
35MP0005464_abnormal_platelet_physiology1.56252481
36MP0002928_abnormal_bile_duct1.55239246
37MP0010234_abnormal_vibrissa_follicle1.52467638
38MP0000015_abnormal_ear_pigmentation1.52133082
39MP0002452_abnormal_antigen_presenting1.47306959
40MP0003890_abnormal_embryonic-extraembry1.46535258
41MP0006054_spinal_hemorrhage1.44240770
42MP0010352_gastrointestinal_tract_polyps1.43153983
43MP0003656_abnormal_erythrocyte_physiolo1.42543812
44MP0004043_abnormal_pH_regulation1.41258653
45MP0010329_abnormal_lipoprotein_level1.40753894
46MP0002419_abnormal_innate_immunity1.39213709
47MP0002877_abnormal_melanocyte_morpholog1.37058016
48MP0009780_abnormal_chondrocyte_physiolo1.36125566
49MP0002138_abnormal_hepatobiliary_system1.33669688
50MP0003950_abnormal_plasma_membrane1.32568804
51MP0001873_stomach_inflammation1.32130602
52MP0002723_abnormal_immune_serum1.31845623
53MP0004947_skin_inflammation1.31497467
54MP0008961_abnormal_basal_metabolism1.30776414
55MP0003436_decreased_susceptibility_to1.26199232
56MP0009278_abnormal_bone_marrow1.26019823
57MP0002420_abnormal_adaptive_immunity1.25296579
58MP0002398_abnormal_bone_marrow1.24963337
59MP0005397_hematopoietic_system_phenotyp1.24741608
60MP0001545_abnormal_hematopoietic_system1.24741608
61MP0001986_abnormal_taste_sensitivity1.24241302
62MP0000013_abnormal_adipose_tissue1.24237539
63MP0001819_abnormal_immune_cell1.23963133
64MP0004484_altered_response_of1.20792485
65MP0002168_other_aberrant_phenotype1.20710931
66MP0001666_abnormal_nutrient_absorption1.19580961
67MP0005671_abnormal_response_to1.15720049
68MP0004084_abnormal_cardiac_muscle1.14390269
69MP0008877_abnormal_DNA_methylation1.14303096
70MP0000609_abnormal_liver_physiology1.13856369
71MP0003763_abnormal_thymus_physiology1.13744028
72MP0008057_abnormal_DNA_replication1.12573445
73MP0003705_abnormal_hypodermis_morpholog1.11054349
74MP0003724_increased_susceptibility_to1.10218151
75MP0009697_abnormal_copulation1.09652556
76MP0001324_abnormal_eye_pigmentation1.09380128
77MP0000689_abnormal_spleen_morphology1.09322748
78MP0000716_abnormal_immune_system1.08168869
79MP0003121_genomic_imprinting1.08027430
80MP0002909_abnormal_adrenal_gland1.07903209
81MP0004142_abnormal_muscle_tone1.05681864
82MP0001661_extended_life_span1.05086994
83MP0005000_abnormal_immune_tolerance1.04757236
84MP0001984_abnormal_olfaction1.03985786
85MP0003632_abnormal_nervous_system1.01191578
86MP0005085_abnormal_gallbladder_physiolo1.00672762
87MP0000427_abnormal_hair_cycle0.99526853
88MP0004883_abnormal_blood_vessel0.98835608
89MP0005025_abnormal_response_to0.97753580
90MP0000703_abnormal_thymus_morphology0.97578754
91MP0003091_abnormal_cell_migration0.96906675
92MP0002722_abnormal_immune_system0.95940288
93MP0004134_abnormal_chest_morphology0.95875206
94MP0002102_abnormal_ear_morphology0.94374066
95MP0010155_abnormal_intestine_physiology0.93905290
96MP0003191_abnormal_cellular_cholesterol0.93087743
97MP0005646_abnormal_pituitary_gland0.92831868
98MP0002095_abnormal_skin_pigmentation0.92777857
99MP0002075_abnormal_coat/hair_pigmentati0.91577398
100MP0009046_muscle_twitch0.91527677
101MP0005386_behavior/neurological_phenoty0.91288718
102MP0004924_abnormal_behavior0.91288718
103MP0002254_reproductive_system_inflammat0.91266286
104MP0009115_abnormal_fat_cell0.89258387
105MP0002332_abnormal_exercise_endurance0.88572680
106MP0001845_abnormal_inflammatory_respons0.88476505
107MP0005075_abnormal_melanosome_morpholog0.87545596
108MP0003866_abnormal_defecation0.86099914
109MP0008995_early_reproductive_senescence0.85746306
110MP0005253_abnormal_eye_physiology0.85654097
111MP0005408_hypopigmentation0.85422501
112MP0004130_abnormal_muscle_cell0.85356970
113MP0002837_dystrophic_cardiac_calcinosis0.85277712
114MP0005220_abnormal_exocrine_pancreas0.84527437
115MP0004510_myositis0.84420589
116MP0005187_abnormal_penis_morphology0.84379273
117MP0005310_abnormal_salivary_gland0.83891850
118MP0002405_respiratory_system_inflammati0.83460288
119MP0002429_abnormal_blood_cell0.82511669
120MP0005266_abnormal_metabolism0.82254848
121MP0003943_abnormal_hepatobiliary_system0.81292835
122MP0000470_abnormal_stomach_morphology0.80880771
123MP0005666_abnormal_adipose_tissue0.80523575
124MP0009703_decreased_birth_body0.80516299
125MP0005645_abnormal_hypothalamus_physiol0.78638496
126MP0003566_abnormal_cell_adhesion0.77796071
127MP0000230_abnormal_systemic_arterial0.77647781
128MP0005551_abnormal_eye_electrophysiolog0.77315254
129MP0003690_abnormal_glial_cell0.76919765
130MP0001486_abnormal_startle_reflex0.76048929
131MP0001915_intracranial_hemorrhage0.75814475
132MP0002998_abnormal_bone_remodeling0.75267062
133MP0004145_abnormal_muscle_electrophysio0.75247373
134MP0005389_reproductive_system_phenotype0.75077446
135MP0003633_abnormal_nervous_system0.74366290
136MP0009763_increased_sensitivity_to0.73658882
137MP0003631_nervous_system_phenotype0.72553536
138MP0002118_abnormal_lipid_homeostasis0.68467957
139MP0005334_abnormal_fat_pad0.68320601
140MP0005275_abnormal_skin_tensile0.68278668
141MP0000604_amyloidosis0.67978844
142MP0002090_abnormal_vision0.67532333
143MP0000598_abnormal_liver_morphology0.67332670
144MP0002229_neurodegeneration0.65678184
145MP0001501_abnormal_sleep_pattern0.64483837
146MP0008775_abnormal_heart_ventricle0.63476077
147MP0010386_abnormal_urinary_bladder0.62935887
148MP0002067_abnormal_sensory_capabilities0.62742090
149MP0005164_abnormal_response_to0.61394184
150MP0008004_abnormal_stomach_pH0.60996967
151MP0002160_abnormal_reproductive_system0.60015395
152MP0000647_abnormal_sebaceous_gland0.59606219
153MP0005376_homeostasis/metabolism_phenot0.58375137
154MP0002108_abnormal_muscle_morphology0.56085345
155MP0005395_other_phenotype0.56081691
156MP0001919_abnormal_reproductive_system0.55555676
157MP0002876_abnormal_thyroid_physiology0.54360959
158MP0004036_abnormal_muscle_relaxation0.53749877
159MP0001958_emphysema0.53329973
160MP0000778_abnormal_nervous_system0.52818583
161MP0006276_abnormal_autonomic_nervous0.52771384

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)4.87697519
2Genetic anticipation (HP:0003743)4.12648895
3Fair hair (HP:0002286)3.78693104
4Hyperventilation (HP:0002883)3.75534305
5Pancreatic cysts (HP:0001737)3.51809371
6Volvulus (HP:0002580)3.32570500
7Absent frontal sinuses (HP:0002688)3.24987992
8Gaze-evoked nystagmus (HP:0000640)3.20619843
9Macroorchidism (HP:0000053)3.18717562
10Pancreatic fibrosis (HP:0100732)3.15401046
11Protruding tongue (HP:0010808)3.14367155
12Abnormality of the renal medulla (HP:0100957)3.11559222
13Progressive cerebellar ataxia (HP:0002073)3.07204443
14Abnormality of the renal cortex (HP:0011035)3.05812340
15Hematochezia (HP:0002573)3.04916335
16Nephronophthisis (HP:0000090)2.95892023
17Colitis (HP:0002583)2.89756221
18Recurrent bacterial skin infections (HP:0005406)2.88851658
19Chronic hepatic failure (HP:0100626)2.88777590
20Periodontitis (HP:0000704)2.71883191
21True hermaphroditism (HP:0010459)2.69862890
22Stomatitis (HP:0010280)2.69748558
23Tubulointerstitial nephritis (HP:0001970)2.59036121
24Aplasia/Hypoplasia of the tibia (HP:0005772)2.54668218
25Abnormality of midbrain morphology (HP:0002418)2.53235046
26Molar tooth sign on MRI (HP:0002419)2.53235046
27Heterotopia (HP:0002282)2.51671496
28Recurrent abscess formation (HP:0002722)2.50730333
29Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.45205128
30Long eyelashes (HP:0000527)2.42587161
31Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.41919632
32Acanthocytosis (HP:0001927)2.41408195
33Recurrent viral infections (HP:0004429)2.40588856
34Hypoplasia of the thymus (HP:0000778)2.39033142
35Poor coordination (HP:0002370)2.37494806
36Absent speech (HP:0001344)2.35820930
37Urethral obstruction (HP:0000796)2.34860374
38* Narrow palate (HP:0000189)2.33023496
39Inflammation of the large intestine (HP:0002037)2.30862693
40Thyroid carcinoma (HP:0002890)2.30571198
41Abnormal hair whorl (HP:0010721)2.30009123
42Stomach cancer (HP:0012126)2.29457276
43Recurrent fungal infections (HP:0002841)2.28882302
44Recurrent gram-negative bacterial infections (HP:0005420)2.28708162
45Febrile seizures (HP:0002373)2.28650477
46Cystic liver disease (HP:0006706)2.25212358
47Chronic diarrhea (HP:0002028)2.24837095
48Gingival bleeding (HP:0000225)2.24612489
49Prominent nose (HP:0000448)2.22817209
50Myocardial infarction (HP:0001658)2.20171945
51Congenital stationary night blindness (HP:0007642)2.17794737
52Medial flaring of the eyebrow (HP:0010747)2.17602676
53Abnormality of the ischium (HP:0003174)2.16212588
54Hip dysplasia (HP:0001385)2.15941510
55Hypochromic microcytic anemia (HP:0004840)2.15797846
56Tented upper lip vermilion (HP:0010804)2.15365768
57Gastrointestinal inflammation (HP:0004386)2.13922032
58Tubular atrophy (HP:0000092)2.13053563
59Hypoplastic iliac wings (HP:0002866)2.12878955
60Mitral stenosis (HP:0001718)2.12679278
61T lymphocytopenia (HP:0005403)2.11945123
62Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.11864762
63Acute myeloid leukemia (HP:0004808)2.11731307
64Eczematoid dermatitis (HP:0000976)2.10624736
65Aortic aneurysm (HP:0004942)2.09931686
66Cerebral aneurysm (HP:0004944)2.06178155
67Spondylolisthesis (HP:0003302)2.05747123
68Gingivitis (HP:0000230)2.03783922
69Hypoplastic ischia (HP:0003175)2.02318696
70Autoimmune thrombocytopenia (HP:0001973)1.99994229
71Renal cortical cysts (HP:0000803)1.99686258
72Lip pit (HP:0100267)1.96708614
73Attenuation of retinal blood vessels (HP:0007843)1.96523541
74Drooling (HP:0002307)1.93477842
75Thyroiditis (HP:0100646)1.93245529
76Clumsiness (HP:0002312)1.92973218
77Abnormality of secondary sexual hair (HP:0009888)1.92167902
78Abnormality of the axillary hair (HP:0100134)1.92167902
79Abnormality of T cell number (HP:0011839)1.91357345
80Abnormality of the nasal septum (HP:0000419)1.91250904
81Congenital primary aphakia (HP:0007707)1.90116467
82Overgrowth (HP:0001548)1.88417099
83Short chin (HP:0000331)1.88321608
84Obsessive-compulsive behavior (HP:0000722)1.88157482
85Gait imbalance (HP:0002141)1.87958876
86Increased CSF protein (HP:0002922)1.85851310
87IgM deficiency (HP:0002850)1.84887523
88Neoplasm of the adrenal cortex (HP:0100641)1.84389741
89Neonatal hypoglycemia (HP:0001998)1.84234853
90Widely spaced teeth (HP:0000687)1.84076116
91Congenital hepatic fibrosis (HP:0002612)1.83981775
92Abnormality of the labia majora (HP:0012881)1.81875882
93Postaxial foot polydactyly (HP:0001830)1.81792075
94Neoplasm of the tracheobronchial system (HP:0100552)1.81330553
95Recurrent skin infections (HP:0001581)1.80353194
96Joint hemorrhage (HP:0005261)1.79872952
97Excessive salivation (HP:0003781)1.79801504
98Generalized hypopigmentation of hair (HP:0011358)1.79631176
99Hyperkalemia (HP:0002153)1.79384075
100Arterial thrombosis (HP:0004420)1.78391322
101* Truncal obesity (HP:0001956)1.78243597
102Anhidrosis (HP:0000970)1.77874215
103Subacute progressive viral hepatitis (HP:0006572)1.77809110
104Broad-based gait (HP:0002136)1.77777630
105Highly arched eyebrow (HP:0002553)1.76189855
106Progressive hearing impairment (HP:0001730)1.75707028
107Hypoplastic labia majora (HP:0000059)1.74987196
108Abnormality of the frontal sinuses (HP:0002687)1.74185481
109Short foot (HP:0001773)1.72680509
110Cellulitis (HP:0100658)1.72578030
111Abnormality of ocular smooth pursuit (HP:0000617)1.72234960
112IgA deficiency (HP:0002720)1.71868373
113Depressed nasal tip (HP:0000437)1.71528120
114Abnormal delayed hypersensitivity skin test (HP:0002963)1.71480942
115Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.71118787
116Genital tract atresia (HP:0001827)1.70470268
117Nephrogenic diabetes insipidus (HP:0009806)1.69754204
118Tubulointerstitial abnormality (HP:0001969)1.69241214
119Submucous cleft hard palate (HP:0000176)1.69099981
120Papillary thyroid carcinoma (HP:0002895)1.68975502
121Impaired smooth pursuit (HP:0007772)1.68555628
122Dysmetric saccades (HP:0000641)1.67823196
123Progressive inability to walk (HP:0002505)1.67595116
124Absent/shortened dynein arms (HP:0200106)1.67356387
125Dynein arm defect of respiratory motile cilia (HP:0012255)1.67356387
126Abnormality of the epiphyses of the hand (HP:0005924)1.66727825
127Aplasia/Hypoplasia of the macula (HP:0008059)1.66534637
128Acute lymphatic leukemia (HP:0006721)1.66302274
129Curly hair (HP:0002212)1.65654491
130Increased number of teeth (HP:0011069)1.64919706
131Spinal cord lesions (HP:0100561)1.64802158
132Syringomyelia (HP:0003396)1.64802158
133Osteomyelitis (HP:0002754)1.63456807
134Upper motor neuron abnormality (HP:0002127)1.63437732
135Abnormality of the wing of the ilium (HP:0011867)1.62585210
136Decreased circulating renin level (HP:0003351)1.62219579
137Aqueductal stenosis (HP:0002410)1.61945922
138Cystic hygroma (HP:0000476)1.61902676
139Chronic mucocutaneous candidiasis (HP:0002728)1.61817516
140Recurrent cutaneous fungal infections (HP:0011370)1.61817516
141Hypoplastic nipples (HP:0002557)1.61128855
142Urinary bladder sphincter dysfunction (HP:0002839)1.61111380
143Poikilocytosis (HP:0004447)1.60738177
144Cerebellar dysplasia (HP:0007033)1.60452327
145Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.59663755
146Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.59131154
147Autoimmune hemolytic anemia (HP:0001890)1.58967575
148Vaginal atresia (HP:0000148)1.58690938
149Abnormality of DNA repair (HP:0003254)1.58531856
150Recurrent bronchitis (HP:0002837)1.58121970
151Abnormality of polysaccharide metabolism (HP:0011012)1.57957845
152Abnormality of glycosaminoglycan metabolism (HP:0004371)1.57957845
153Abnormality of mucopolysaccharide metabolism (HP:0011020)1.57957845
154* Thick eyebrow (HP:0000574)1.57824319
155Abnormality of the common coagulation pathway (HP:0010990)1.57594895
156Smooth philtrum (HP:0000319)1.57531077
157Ectropion (HP:0000656)1.56948400
158Hypoglycemic seizures (HP:0002173)1.56363415
159Ocular albinism (HP:0001107)1.55747393
160Enlarged penis (HP:0000040)1.55236634
161Mediastinal lymphadenopathy (HP:0100721)1.54733449
162Vasculitis (HP:0002633)1.53246982
163Aneurysm (HP:0002617)1.52270717
164Progressive sensorineural hearing impairment (HP:0000408)1.52114778
165Deep philtrum (HP:0002002)1.50402418
166Hypoalphalipoproteinemia (HP:0003233)1.49733148
167Conjugated hyperbilirubinemia (HP:0002908)1.49544233
168Portal hypertension (HP:0001409)1.49420028
169Agammaglobulinemia (HP:0004432)1.49082691
170Anal stenosis (HP:0002025)1.48926666
171Abnormality of endocrine pancreas physiology (HP:0012093)1.48258117
172Abnormality of the pancreatic islet cells (HP:0006476)1.48258117
173Spontaneous hematomas (HP:0007420)1.48101024
174Generalized hypopigmentation (HP:0007513)1.47710040
175Abnormal platelet volume (HP:0011876)1.47309308

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK123.55901037
2CAMK1D3.47366511
3CAMK1G3.03629849
4AKT32.94822233
5TAOK32.88402730
6FRK2.63230502
7BRD42.39201087
8INSRR2.38019867
9MAP4K22.36147785
10JAK12.26075900
11TYK22.02177921
12BMPR1B2.00035815
13SIK11.99640128
14ACVR1B1.99046620
15MAP4K11.94129913
16MAP3K101.93994572
17FGFR31.91403475
18SGK31.86058799
19RIPK11.81201869
20SGK21.63298675
21RIPK41.61574388
22NLK1.60020805
23MAP3K41.58027480
24PIK3CG1.56789676
25MAP3K131.51812630
26SIK21.51455486
27JAK31.36462927
28MAP3K141.32839106
29PTK61.32787072
30CSF1R1.32517029
31SCYL21.29295174
32CDK91.19572812
33MAPK131.18282346
34NUAK11.15103391
35PAK31.14684912
36PTK2B1.13271512
37FGFR21.11687162
38LATS11.11601888
39MAP3K71.11104327
40BLK1.11099651
41FGFR41.10919989
42IKBKE1.05349676
43WNK31.05056644
44EEF2K1.04802270
45STK31.03273294
46STK391.02991111
47TNIK1.00217701
48CDK60.98850963
49WNK10.98817717
50MAP3K60.97667754
51CHUK0.97291117
52TTN0.97084454
53OXSR10.96735469
54CASK0.96271630
55IRAK10.94831329
56HCK0.94736462
57MTOR0.94615194
58JAK20.94242885
59TGFBR20.93362059
60KIT0.92038958
61PDGFRB0.90786726
62ITK0.90016877
63PKN20.89516598
64PRKCH0.89229290
65CSK0.87889792
66STK38L0.87775682
67SGK10.86341029
68STK40.85120097
69GRK10.84087541
70FER0.81965918
71STK380.81519171
72NEK60.80254788
73ADRBK20.80062751
74STK100.79744995
75HIPK20.79341313
76PRKAA20.78203988
77NTRK30.77417597
78PDK10.75926530
79ATR0.73866508
80NEK20.72809542
81BTK0.72059730
82PRKAA10.72021848
83SYK0.71501357
84ADRBK10.70166386
85MARK30.69785137
86MAP2K40.69418548
87SGK2230.69153574
88SGK4940.69153574
89ERBB30.68731188
90TXK0.67964355
91LCK0.67958779
92EPHA30.67105646
93TEC0.66547193
94ERBB20.65877205
95MAP3K20.65623497
96ERN10.65190949
97EGFR0.64858407
98RET0.64387673
99SIK30.64127685
100NEK90.64029286
101PRKCQ0.61627451
102TNK20.61581542
103FES0.61498714
104RPS6KB10.60710797
105ATM0.59953709
106STK110.59317428
107DAPK20.59063063
108TRIB30.58798435
109ZAP700.57869919
110MELK0.57612987
111ZAK0.57348221
112BRSK20.57288173
113YES10.56232312
114PIM10.55849451
115PLK20.54182014
116MST1R0.52396298
117TRPM70.51633787
118IRAK30.50940940
119CAMK40.50541095
120BMPR20.50530012
121FLT30.49428902
122MARK20.49128948
123IKBKB0.48846806
124GRK60.48829477
125OBSCN0.48500052
126CDC70.47722706
127MAPK100.47676334
128MKNK20.47565473
129MAPK70.47019057
130CAMK10.46484456
131CAMKK10.46354794
132DYRK1A0.44835504
133CAMKK20.44357382
134MAP2K60.43659733
135PDPK10.43384096
136TGFBR10.42928925
137PRKCE0.42290253
138PIK3CA0.42275695
139CDC42BPA0.42214491
140PNCK0.40830645
141WNK40.37624051
142BCR0.37458187
143CSNK1D0.36126999

Predicted pathways (KEGG)

RankGene SetZ-score
1Lysine degradation_Homo sapiens_hsa003102.29279229
2Type II diabetes mellitus_Homo sapiens_hsa049302.04818403
3Nitrogen metabolism_Homo sapiens_hsa009101.98609192
4Caffeine metabolism_Homo sapiens_hsa002321.82436308
5ABC transporters_Homo sapiens_hsa020101.78610496
6B cell receptor signaling pathway_Homo sapiens_hsa046621.71892799
7Phosphatidylinositol signaling system_Homo sapiens_hsa040701.69820615
8Carbohydrate digestion and absorption_Homo sapiens_hsa049731.65589997
9Osteoclast differentiation_Homo sapiens_hsa043801.50870311
10Inositol phosphate metabolism_Homo sapiens_hsa005621.45086035
11mTOR signaling pathway_Homo sapiens_hsa041501.41193762
12NF-kappa B signaling pathway_Homo sapiens_hsa040641.30565201
13Insulin resistance_Homo sapiens_hsa049311.30102058
14Systemic lupus erythematosus_Homo sapiens_hsa053221.27952193
15Dorso-ventral axis formation_Homo sapiens_hsa043201.22521596
16Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.21310222
17Phototransduction_Homo sapiens_hsa047441.21075935
18Staphylococcus aureus infection_Homo sapiens_hsa051501.18864746
19alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.15867334
20Chronic myeloid leukemia_Homo sapiens_hsa052201.13546546
21Taste transduction_Homo sapiens_hsa047421.12497916
22Linoleic acid metabolism_Homo sapiens_hsa005911.10660901
23Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.06551642
24Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.04635260
25Complement and coagulation cascades_Homo sapiens_hsa046101.04373329
26Thyroid hormone signaling pathway_Homo sapiens_hsa049191.02913240
27Vascular smooth muscle contraction_Homo sapiens_hsa042701.02359786
28Measles_Homo sapiens_hsa051621.02225453
29Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.01999448
30Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.98144531
31Primary immunodeficiency_Homo sapiens_hsa053400.97771978
32Regulation of autophagy_Homo sapiens_hsa041400.97143186
33Toll-like receptor signaling pathway_Homo sapiens_hsa046200.94214159
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.94002327
35Pancreatic cancer_Homo sapiens_hsa052120.93751616
36Platelet activation_Homo sapiens_hsa046110.93538396
37Calcium signaling pathway_Homo sapiens_hsa040200.93037636
38Ether lipid metabolism_Homo sapiens_hsa005650.92982171
39Glucagon signaling pathway_Homo sapiens_hsa049220.92318611
40Glutamatergic synapse_Homo sapiens_hsa047240.91921369
41Chemokine signaling pathway_Homo sapiens_hsa040620.91381380
42Leishmaniasis_Homo sapiens_hsa051400.90839768
43Circadian entrainment_Homo sapiens_hsa047130.90663789
44Nicotine addiction_Homo sapiens_hsa050330.90000987
45Long-term depression_Homo sapiens_hsa047300.89893835
46Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.89862248
47Cholinergic synapse_Homo sapiens_hsa047250.89728744
48Non-small cell lung cancer_Homo sapiens_hsa052230.89078467
49Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.88833389
50Toxoplasmosis_Homo sapiens_hsa051450.88626357
51Insulin secretion_Homo sapiens_hsa049110.88270003
52T cell receptor signaling pathway_Homo sapiens_hsa046600.87787143
53Influenza A_Homo sapiens_hsa051640.85986814
54Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.85701234
55Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.85204770
56Longevity regulating pathway - mammal_Homo sapiens_hsa042110.84888836
57Glycosaminoglycan degradation_Homo sapiens_hsa005310.84376841
58Glioma_Homo sapiens_hsa052140.84263556
59Small cell lung cancer_Homo sapiens_hsa052220.84086278
60Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.83118587
61Bile secretion_Homo sapiens_hsa049760.82876228
62Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.82425034
63Aldosterone synthesis and secretion_Homo sapiens_hsa049250.82264213
64Oxytocin signaling pathway_Homo sapiens_hsa049210.81796375
65Insulin signaling pathway_Homo sapiens_hsa049100.81771385
66Transcriptional misregulation in cancer_Homo sapiens_hsa052020.80741164
67Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.80482560
68Serotonergic synapse_Homo sapiens_hsa047260.80280089
69Neurotrophin signaling pathway_Homo sapiens_hsa047220.79998423
70Prolactin signaling pathway_Homo sapiens_hsa049170.79800444
71Fanconi anemia pathway_Homo sapiens_hsa034600.79746944
72Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.78720324
73NOD-like receptor signaling pathway_Homo sapiens_hsa046210.78684869
74TNF signaling pathway_Homo sapiens_hsa046680.78354938
75Primary bile acid biosynthesis_Homo sapiens_hsa001200.78097386
76Jak-STAT signaling pathway_Homo sapiens_hsa046300.77335567
77Acute myeloid leukemia_Homo sapiens_hsa052210.76574788
78Renin secretion_Homo sapiens_hsa049240.76205691
79Adipocytokine signaling pathway_Homo sapiens_hsa049200.75607931
80Ovarian steroidogenesis_Homo sapiens_hsa049130.74529250
81ErbB signaling pathway_Homo sapiens_hsa040120.74450143
82Tuberculosis_Homo sapiens_hsa051520.74346703
83Hepatitis B_Homo sapiens_hsa051610.74140798
84Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.73788517
85Butanoate metabolism_Homo sapiens_hsa006500.72990303
86Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.72500325
87Viral carcinogenesis_Homo sapiens_hsa052030.72408403
88Glycerolipid metabolism_Homo sapiens_hsa005610.71747274
89Hepatitis C_Homo sapiens_hsa051600.70441595
90Hematopoietic cell lineage_Homo sapiens_hsa046400.68463349
91Herpes simplex infection_Homo sapiens_hsa051680.67712744
92cGMP-PKG signaling pathway_Homo sapiens_hsa040220.67092744
93FoxO signaling pathway_Homo sapiens_hsa040680.66731294
94Non-homologous end-joining_Homo sapiens_hsa034500.66675798
95Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.66196104
96Endometrial cancer_Homo sapiens_hsa052130.65389256
97AMPK signaling pathway_Homo sapiens_hsa041520.65212340
98Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.65117940
99Arginine biosynthesis_Homo sapiens_hsa002200.65116255
100MicroRNAs in cancer_Homo sapiens_hsa052060.64888531
101MAPK signaling pathway_Homo sapiens_hsa040100.64864562
102Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.64845470
103GnRH signaling pathway_Homo sapiens_hsa049120.64679170
104Circadian rhythm_Homo sapiens_hsa047100.64518301
105TGF-beta signaling pathway_Homo sapiens_hsa043500.63952040
106Central carbon metabolism in cancer_Homo sapiens_hsa052300.63144725
107Selenocompound metabolism_Homo sapiens_hsa004500.62572384
108Ras signaling pathway_Homo sapiens_hsa040140.61392696
109RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.60855267
110Prostate cancer_Homo sapiens_hsa052150.60522450
111Phospholipase D signaling pathway_Homo sapiens_hsa040720.59950582
112Sphingolipid signaling pathway_Homo sapiens_hsa040710.59928745
113PPAR signaling pathway_Homo sapiens_hsa033200.59465231
114Salivary secretion_Homo sapiens_hsa049700.59389504
115Estrogen signaling pathway_Homo sapiens_hsa049150.59343503
116Fatty acid biosynthesis_Homo sapiens_hsa000610.59280718
117Leukocyte transendothelial migration_Homo sapiens_hsa046700.58833938
118Steroid hormone biosynthesis_Homo sapiens_hsa001400.57660193
119Long-term potentiation_Homo sapiens_hsa047200.57578951
120Glycerophospholipid metabolism_Homo sapiens_hsa005640.57384752
121Melanoma_Homo sapiens_hsa052180.56868267
122Sphingolipid metabolism_Homo sapiens_hsa006000.56586349
123Alcoholism_Homo sapiens_hsa050340.56456181
124Dopaminergic synapse_Homo sapiens_hsa047280.56386737
125GABAergic synapse_Homo sapiens_hsa047270.55535395
126cAMP signaling pathway_Homo sapiens_hsa040240.55204685
127Proteoglycans in cancer_Homo sapiens_hsa052050.55146312
128Adherens junction_Homo sapiens_hsa045200.55022102
129Renal cell carcinoma_Homo sapiens_hsa052110.54826569
130Maturity onset diabetes of the young_Homo sapiens_hsa049500.54804889
131Choline metabolism in cancer_Homo sapiens_hsa052310.54618927
132Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.54294069
133Olfactory transduction_Homo sapiens_hsa047400.54107180
134Thyroid hormone synthesis_Homo sapiens_hsa049180.53363948
135Intestinal immune network for IgA production_Homo sapiens_hsa046720.52197716
136Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.51966154
137Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.51532205
138Morphine addiction_Homo sapiens_hsa050320.51451826
139AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.50131716
140Renin-angiotensin system_Homo sapiens_hsa046140.49970587
141Pancreatic secretion_Homo sapiens_hsa049720.49739656

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