VPS13C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the vacuolar protein sorting-associated 13 gene family. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of B cell receptor signaling pathway (GO:0050855)4.77298200
2phospholipid homeostasis (GO:0055091)4.60984484
3regulation of gamma-delta T cell differentiation (GO:0045586)4.21481270
4macroautophagy (GO:0016236)4.11675218
5B cell receptor signaling pathway (GO:0050853)4.09008865
6regulation of gamma-delta T cell activation (GO:0046643)4.08592175
7positive regulation of granulocyte differentiation (GO:0030854)3.80968078
8negative T cell selection (GO:0043383)3.72744785
9negative thymic T cell selection (GO:0045060)3.67117987
10dicarboxylic acid biosynthetic process (GO:0043650)3.64663374
11interkinetic nuclear migration (GO:0022027)3.63920385
12positive T cell selection (GO:0043368)3.57371916
13lipoprotein transport (GO:0042953)3.37910319
14negative regulation of cell killing (GO:0031342)3.35470785
15negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.35470785
16regulation of sequestering of triglyceride (GO:0010889)3.34051633
17monoubiquitinated protein deubiquitination (GO:0035520)3.28138431
18microglial cell activation (GO:0001774)3.28135449
19antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.23989444
20low-density lipoprotein particle clearance (GO:0034383)3.21990634
21cellular extravasation (GO:0045123)3.21876273
22histone H3-K4 trimethylation (GO:0080182)3.19393998
23apoptotic cell clearance (GO:0043277)3.19318982
24detection of molecule of bacterial origin (GO:0032490)3.16514986
25regulation of cholesterol storage (GO:0010885)3.16301320
26regulation of ARF protein signal transduction (GO:0032012)3.15804255
27positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.14996059
28positive thymic T cell selection (GO:0045059)3.10874657
29activated T cell proliferation (GO:0050798)3.04550789
30mannose metabolic process (GO:0006013)3.02860456
31hepatocyte apoptotic process (GO:0097284)3.02112411
32establishment of protein localization to Golgi (GO:0072600)3.01639351
33negative regulation of T cell mediated immunity (GO:0002710)3.01248564
34retrograde transport, vesicle recycling within Golgi (GO:0000301)2.99978285
35positive regulation of fatty acid beta-oxidation (GO:0032000)2.97227534
36antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.96645020
37positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.94488023
38definitive hemopoiesis (GO:0060216)2.91421011
39urea metabolic process (GO:0019627)2.89969385
40urea cycle (GO:0000050)2.89969385
41T cell selection (GO:0045058)2.87985468
42positive regulation of B cell differentiation (GO:0045579)2.87355209
43nucleus localization (GO:0051647)2.86413635
44fatty acid transmembrane transport (GO:1902001)2.85168561
45positive regulation of p38MAPK cascade (GO:1900745)2.84396582
46regulation of beta-amyloid formation (GO:1902003)2.83698530
47antigen processing and presentation of endogenous antigen (GO:0019883)2.82337918
48positive regulation of cholesterol efflux (GO:0010875)2.82309538
49regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.81466693
50response to interleukin-15 (GO:0070672)2.80739725
51protein targeting to Golgi (GO:0000042)2.80531298
52regulation of B cell differentiation (GO:0045577)2.80214512
53negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.79020245
54antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.78704082
55cerebellar Purkinje cell differentiation (GO:0021702)2.76596038
56positive regulation of histone deacetylation (GO:0031065)2.76392955
57carnitine shuttle (GO:0006853)2.74455018
58macrophage activation (GO:0042116)2.74133943
59regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.73696701
60regulation of pigment cell differentiation (GO:0050932)2.73255893
61negative regulation of neurotransmitter secretion (GO:0046929)2.73189908
62neutrophil mediated immunity (GO:0002446)2.72549027
63T cell migration (GO:0072678)2.72364916
64modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.71591182
65positive regulation by organism of defense response of other organism involved in symbiotic interact2.71591182
66modulation by symbiont of host immune response (GO:0052553)2.71591182
67positive regulation by symbiont of host defense response (GO:0052509)2.71591182
68modulation by symbiont of host defense response (GO:0052031)2.71591182
69modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.71591182
70negative regulation of B cell proliferation (GO:0030889)2.70962074
71regulation of fatty acid beta-oxidation (GO:0031998)2.70417291
72negative regulation of lymphocyte mediated immunity (GO:0002707)2.69675334
73negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.68491503
74positive regulation of Rap GTPase activity (GO:0032854)2.68167485
75complement activation, alternative pathway (GO:0006957)2.68057090
76interleukin-6-mediated signaling pathway (GO:0070102)2.67584737
77alpha-linolenic acid metabolic process (GO:0036109)2.67117990
78interferon-gamma production (GO:0032609)2.67075157
79positive regulation of sterol transport (GO:0032373)2.66440488
80positive regulation of cholesterol transport (GO:0032376)2.66440488
81positive regulation of gamma-delta T cell activation (GO:0046645)2.65655005
82cytoplasmic mRNA processing body assembly (GO:0033962)2.64255029
83regulation of protein polyubiquitination (GO:1902914)2.63812973
84alanine transport (GO:0032328)2.61004123
85protein targeting to vacuole (GO:0006623)2.60147267
86protein targeting to lysosome (GO:0006622)2.60147267
87establishment of protein localization to vacuole (GO:0072666)2.60147267
88negative regulation of granulocyte differentiation (GO:0030853)2.60022344
89negative regulation of neurotransmitter transport (GO:0051589)2.59596912
90negative regulation of lipid storage (GO:0010888)2.58935814
91cellular response to interleukin-15 (GO:0071350)2.57441153
92protein K48-linked deubiquitination (GO:0071108)2.57351249
93regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.56509970
94plasma lipoprotein particle clearance (GO:0034381)2.55863043
95negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.55836339
96establishment of nucleus localization (GO:0040023)2.55385524
97early endosome to late endosome transport (GO:0045022)2.55285626
98protein K11-linked deubiquitination (GO:0035871)2.54879902
99negative regulation of adaptive immune response (GO:0002820)2.54695979
100I-kappaB phosphorylation (GO:0007252)2.53698498
101regulation of interleukin-12 biosynthetic process (GO:0045075)2.52477571
102regulation of granulocyte differentiation (GO:0030852)2.51479734
103regulation of translation, ncRNA-mediated (GO:0045974)2.51104553
104negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.51104553
105negative regulation of translation, ncRNA-mediated (GO:0040033)2.51104553
106insulin-like growth factor receptor signaling pathway (GO:0048009)2.49815788
107fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.49631923
108mature B cell differentiation (GO:0002335)2.49068228
109histone mRNA catabolic process (GO:0071044)2.48851980
110cellular response to ethanol (GO:0071361)2.48035758
111embryonic retina morphogenesis in camera-type eye (GO:0060059)2.47879771
112regulation of interferon-beta biosynthetic process (GO:0045357)2.47663263
113positive regulation of developmental pigmentation (GO:0048087)2.47630968
114L-alpha-amino acid transmembrane transport (GO:1902475)2.47427690
115histone H3-K9 demethylation (GO:0033169)2.46227618
116growth hormone receptor signaling pathway (GO:0060396)2.43881900
117Golgi to endosome transport (GO:0006895)2.43787689
118phospholipid dephosphorylation (GO:0046839)2.43714610
119regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.43622372
120regulation of tolerance induction (GO:0002643)2.43480995
121detection of external biotic stimulus (GO:0098581)2.43386003
122nitrogen cycle metabolic process (GO:0071941)2.43287058
123regulation of Rap GTPase activity (GO:0032317)2.42066436
124negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.41168829
125negative regulation of T-helper cell differentiation (GO:0045623)2.41168829
126positive regulation of fatty acid oxidation (GO:0046321)2.40419212
127B cell proliferation (GO:0042100)2.39865729
128positive regulation of lipid catabolic process (GO:0050996)2.37973115
129regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.37568262
130regulation of alpha-beta T cell proliferation (GO:0046640)2.37229799
131phosphatidylinositol dephosphorylation (GO:0046856)2.37138177
132histone H3-K4 methylation (GO:0051568)2.35859114
133NLS-bearing protein import into nucleus (GO:0006607)2.35794260
134thymic T cell selection (GO:0045061)2.35252009
135positive regulation of glycolytic process (GO:0045821)2.35065036
136negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.34177963
137regulation of clathrin-mediated endocytosis (GO:2000369)2.34167616
138glycogen catabolic process (GO:0005980)2.34080516
139positive regulation of tolerance induction (GO:0002645)2.33777653
140positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.33287921
141detection of other organism (GO:0098543)2.32911102
142intracellular lipid transport (GO:0032365)2.30250008
143neural tube formation (GO:0001841)2.30148149
144CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.29974742
145T-helper cell differentiation (GO:0042093)2.29974742
146fatty acid homeostasis (GO:0055089)2.29395632
147positive regulation of cellular amide metabolic process (GO:0034250)2.27225576
148cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.25429583
149plasma lipoprotein particle assembly (GO:0034377)2.25116438
150protein-lipid complex assembly (GO:0065005)2.24594416
151positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.23295180
152positive regulation of phagocytosis (GO:0050766)2.22746898
153macrophage activation involved in immune response (GO:0002281)2.20893514
154regulation of apoptotic cell clearance (GO:2000425)2.20749781
155glucan catabolic process (GO:0009251)2.20593853
156regulation of integrin activation (GO:0033623)2.20241457
157phospholipid efflux (GO:0033700)2.19754081
158modification by symbiont of host morphology or physiology (GO:0044003)2.19275535
159cholesterol efflux (GO:0033344)2.19193956
160peptidyl-glutamic acid carboxylation (GO:0017187)2.18455442
161protein carboxylation (GO:0018214)2.18455442
162cellular polysaccharide catabolic process (GO:0044247)2.18304307
163histone H3-K36 demethylation (GO:0070544)2.17660516
164sodium ion export (GO:0071436)2.16282296
165phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.15638810
166peptidyl-lysine trimethylation (GO:0018023)2.13590997
167regulation of macrophage derived foam cell differentiation (GO:0010743)2.13262273
168negative regulation of interleukin-1 beta production (GO:0032691)2.13095068
169lipid translocation (GO:0034204)2.12178738
170phospholipid translocation (GO:0045332)2.12178738
171vesicle transport along microtubule (GO:0047496)2.11898158

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA1_22025678_ChIP-Seq_K562_Human2.69719363
2Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.68697125
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.59488433
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.58920569
5* NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.42997258
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.42912612
7LXR_22158963_ChIP-Seq_LIVER_Mouse2.42047293
8RXR_22158963_ChIP-Seq_LIVER_Mouse2.27731011
9VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.17816411
10BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.16356055
11SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.14841357
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.14014501
13DROSHA_22980978_ChIP-Seq_HELA_Human1.99800745
14PPARA_22158963_ChIP-Seq_LIVER_Mouse1.94073584
15GBX2_23144817_ChIP-Seq_PC3_Human1.85704445
16FOXA2_19822575_ChIP-Seq_HepG2_Human1.82919711
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.81523019
18SPI1_23127762_ChIP-Seq_K562_Human1.77945372
19* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.75130470
20FLI1_27457419_Chip-Seq_LIVER_Mouse1.69284800
21ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.68746591
22NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.68463654
23ZNF217_24962896_ChIP-Seq_MCF-7_Human1.65915432
24* IRF8_27001747_Chip-Seq_BMDM_Mouse1.65453890
25TP53_16413492_ChIP-PET_HCT116_Human1.64816282
26STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.62504743
27EGR1_19374776_ChIP-ChIP_THP-1_Human1.60057368
28SALL1_21062744_ChIP-ChIP_HESCs_Human1.59385497
29ZFP57_27257070_Chip-Seq_ESCs_Mouse1.57217731
30SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.55526399
31FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.54912660
32CTNNB1_20460455_ChIP-Seq_HCT116_Human1.54545584
33* IRF8_22096565_ChIP-ChIP_GC-B_Human1.47719058
34GATA2_21666600_ChIP-Seq_HMVEC_Human1.47194950
35ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.46677800
36* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.43848533
37* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.41882246
38MYB_26560356_Chip-Seq_TH2_Human1.41833354
39TAF15_26573619_Chip-Seq_HEK293_Human1.39046693
40PCGF2_27294783_Chip-Seq_ESCs_Mouse1.38290444
41SMAD_19615063_ChIP-ChIP_OVARY_Human1.37792194
42EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.37009567
43AHR_22903824_ChIP-Seq_MCF-7_Human1.36822932
44OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36079928
45AR_21572438_ChIP-Seq_LNCaP_Human1.35749893
46GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34607716
47TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.34086021
48SCL_19346495_ChIP-Seq_HPC-7_Human1.33719024
49FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.32865471
50MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.32711319
51CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.32466553
52TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.32303969
53CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.30364310
54FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.29321283
55NANOG_18555785_Chip-Seq_ESCs_Mouse1.29270155
56DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.29130803
57RUNX_20019798_ChIP-Seq_JUKART_Human1.28963823
58STAT3_23295773_ChIP-Seq_U87_Human1.28556540
59MYB_21317192_ChIP-Seq_ERMYB_Mouse1.28244845
60EZH2_27294783_Chip-Seq_NPCs_Mouse1.27801461
61CDX2_19796622_ChIP-Seq_MESCs_Mouse1.27542633
62RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.27311496
63ARNT_22903824_ChIP-Seq_MCF-7_Human1.27247065
64PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.27007635
65SUZ12_27294783_Chip-Seq_NPCs_Mouse1.26390089
66FOXO3_23340844_ChIP-Seq_DLD1_Human1.26156515
67VDR_24787735_ChIP-Seq_THP-1_Human1.26033900
68ER_23166858_ChIP-Seq_MCF-7_Human1.25914264
69PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.23845331
70* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.23712162
71GATA1_19941826_ChIP-Seq_K562_Human1.23147474
72* GATA3_27048872_Chip-Seq_THYMUS_Human1.23083227
73SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22315796
74* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21836713
75TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.20661519
76IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.18883945
77* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.17437842
78FOXM1_26456572_ChIP-Seq_MCF-7_Human1.17368328
79* PRDM14_20953172_ChIP-Seq_ESCs_Human1.17164037
80RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16636756
81FLI1_21867929_ChIP-Seq_TH2_Mouse1.16389901
82E2F1_18555785_Chip-Seq_ESCs_Mouse1.16229607
83WT1_25993318_ChIP-Seq_PODOCYTE_Human1.15230708
84GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14937674
85IRF8_21731497_ChIP-ChIP_J774_Mouse1.14073273
86BRD4_27068464_Chip-Seq_AML-cells_Mouse1.13893611
87STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.13715736
88* GATA1_19941827_ChIP-Seq_MEL_Mouse1.13355559
89IGF1R_20145208_ChIP-Seq_DFB_Human1.12865497
90FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.12476579
91EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.12444801
92TCF7_22412390_ChIP-Seq_EML_Mouse1.12125147
93NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.11584687
94OCT4_21477851_ChIP-Seq_ESCs_Mouse1.11539948
95RARB_27405468_Chip-Seq_BRAIN_Mouse1.11252763
96* SOX2_21211035_ChIP-Seq_LN229_Gbm1.11193197
97P300_19829295_ChIP-Seq_ESCs_Human1.10941420
98* SMAD4_21799915_ChIP-Seq_A2780_Human1.10772006
99NFE2_27457419_Chip-Seq_LIVER_Mouse1.10561883
100ESR1_20079471_ChIP-ChIP_T-47D_Human1.10548343
101* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.10326458
102KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.10237745
103CMYC_18555785_Chip-Seq_ESCs_Mouse1.09665413
104KDM2B_26808549_Chip-Seq_SUP-B15_Human1.08782801
105SOX9_24532713_ChIP-Seq_HFSC_Mouse1.08709166
106BCAT_22108803_ChIP-Seq_LS180_Human1.08451189
107GATA2_19941826_ChIP-Seq_K562_Human1.08252171
108P53_22387025_ChIP-Seq_ESCs_Mouse1.08246712
109* TCF4_23295773_ChIP-Seq_U87_Human1.07442617
110PCGF2_27294783_Chip-Seq_NPCs_Mouse1.07406669
111GATA3_26560356_Chip-Seq_TH2_Human1.06903395
112EGR1_23403033_ChIP-Seq_LIVER_Mouse1.06759500
113SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.06054070
114ESR2_21235772_ChIP-Seq_MCF-7_Human1.05708925
115ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05553628
116PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05193614
117AR_19668381_ChIP-Seq_PC3_Human1.04483716
118MYB_26560356_Chip-Seq_TH1_Human1.04202445
119TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.03599879
120KDM2B_26808549_Chip-Seq_DND41_Human1.03429661
121PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02818725
122SUZ12_18555785_Chip-Seq_ESCs_Mouse1.02607899
123TBX20_22328084_ChIP-Seq_HEART_Mouse1.01245659
124TBX20_22080862_ChIP-Seq_HEART_Mouse1.01245659
125GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.01166146
126SMAD3_21741376_ChIP-Seq_EPCs_Human1.00612599
127CRX_20693478_ChIP-Seq_RETINA_Mouse1.00537639
128* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00534919
129TP63_23658742_ChIP-Seq_EP156T_Human1.00478394
130FUS_26573619_Chip-Seq_HEK293_Human0.99818493
131IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.99375926
132NRF2_20460467_ChIP-Seq_MEFs_Mouse0.98130383
133NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.98130383
134PPAR_26484153_Chip-Seq_NCI-H1993_Human0.97064655
135TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96505628
136PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.96314179
137ESR1_21235772_ChIP-Seq_MCF-7_Human0.95895517
138NR3C1_23031785_ChIP-Seq_PC12_Mouse0.95577140
139* AR_25329375_ChIP-Seq_VCAP_Human0.95542835
140* CDX2_22108803_ChIP-Seq_LS180_Human0.95489893
141KDM2B_26808549_Chip-Seq_K562_Human0.95325283
142PU_27001747_Chip-Seq_BMDM_Mouse0.94827111
143* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.93994432
144THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.92915461
145* RXR_22108803_ChIP-Seq_LS180_Human0.92758155
146AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.92270064
147* PIAS1_25552417_ChIP-Seq_VCAP_Human0.91744907
148* HNF4A_19822575_ChIP-Seq_HepG2_Human0.91692335
149CLOCK_20551151_ChIP-Seq_293T_Human0.90424052

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation8.75569937
2MP0008057_abnormal_DNA_replication3.73825024
3MP0003172_abnormal_lysosome_physiology3.56094655
4MP0002009_preneoplasia3.38419144
5MP0003763_abnormal_thymus_physiology3.02421480
6MP0005670_abnormal_white_adipose2.89089131
7MP0005058_abnormal_lysosome_morphology2.78421514
8MP0005365_abnormal_bile_salt2.71142286
9MP0003724_increased_susceptibility_to2.63796722
10MP0004130_abnormal_muscle_cell2.54924974
11MP0003300_gastrointestinal_ulcer2.52975925
12MP0002139_abnormal_hepatobiliary_system2.46930994
13MP0005360_urolithiasis2.41925846
14MP0001800_abnormal_humoral_immune2.32674048
15MP0005174_abnormal_tail_pigmentation2.27997196
16MP0003705_abnormal_hypodermis_morpholog2.19722603
17MP0003252_abnormal_bile_duct2.19040010
18MP0003183_abnormal_peptide_metabolism2.15344373
19MP0003045_fibrosis2.13346665
20MP0010329_abnormal_lipoprotein_level2.12336534
21MP0002166_altered_tumor_susceptibility2.02375890
22MP0004859_abnormal_synaptic_plasticity1.99893015
23MP0000685_abnormal_immune_system1.96613795
24MP0005310_abnormal_salivary_gland1.95049852
25MP0000015_abnormal_ear_pigmentation1.93815545
26MP0005671_abnormal_response_to1.91365701
27MP0000371_diluted_coat_color1.91097455
28MP0005387_immune_system_phenotype1.88442428
29MP0001790_abnormal_immune_system1.88442428
30MP0003191_abnormal_cellular_cholesterol1.84437461
31MP0009780_abnormal_chondrocyte_physiolo1.79000861
32MP0005085_abnormal_gallbladder_physiolo1.71118653
33MP0004510_myositis1.70212638
34MP0002723_abnormal_immune_serum1.69894312
35MP0002452_abnormal_antigen_presenting1.68775840
36MP0005666_abnormal_adipose_tissue1.68364217
37MP0005000_abnormal_immune_tolerance1.63989810
38MP0002420_abnormal_adaptive_immunity1.63756823
39MP0003690_abnormal_glial_cell1.63258048
40MP0004883_abnormal_blood_vessel1.62395767
41MP0010307_abnormal_tumor_latency1.60096430
42MP0001819_abnormal_immune_cell1.60010715
43MP0005076_abnormal_cell_differentiation1.54387890
44MP0003866_abnormal_defecation1.54125696
45MP0008961_abnormal_basal_metabolism1.52183747
46MP0004808_abnormal_hematopoietic_stem1.50622999
47MP0000604_amyloidosis1.49728883
48MP0002405_respiratory_system_inflammati1.49551399
49MP0006054_spinal_hemorrhage1.47206203
50MP0000465_gastrointestinal_hemorrhage1.47108479
51MP0003828_pulmonary_edema1.46202972
52MP0003303_peritoneal_inflammation1.45776899
53MP0009840_abnormal_foam_cell1.43364558
54MP0005025_abnormal_response_to1.42295319
55MP0003566_abnormal_cell_adhesion1.42198689
56MP0004185_abnormal_adipocyte_glucose1.41958994
57MP0002398_abnormal_bone_marrow1.40796013
58MP0004381_abnormal_hair_follicle1.40705022
59MP0005083_abnormal_biliary_tract1.39199597
60MP0004484_altered_response_of1.35219917
61MP0000609_abnormal_liver_physiology1.34056243
62MP0002118_abnormal_lipid_homeostasis1.33699540
63MP0008438_abnormal_cutaneous_collagen1.32538715
64MP0002006_tumorigenesis1.32103965
65MP0000716_abnormal_immune_system1.31490192
66MP0005075_abnormal_melanosome_morpholog1.30421392
67MP0005464_abnormal_platelet_physiology1.29794501
68MP0006082_CNS_inflammation1.29614958
69MP0000689_abnormal_spleen_morphology1.28028694
70MP0005375_adipose_tissue_phenotype1.25880074
71MP0000703_abnormal_thymus_morphology1.23200222
72MP0009785_altered_susceptibility_to1.22010439
73MP0009278_abnormal_bone_marrow1.21932411
74MP0002971_abnormal_brown_adipose1.19930743
75MP0002928_abnormal_bile_duct1.17617865
76MP0002837_dystrophic_cardiac_calcinosis1.15621362
77MP0003868_abnormal_feces_composition1.15134839
78MP0001851_eye_inflammation1.15041578
79MP0010155_abnormal_intestine_physiology1.14961060
80MP0010678_abnormal_skin_adnexa1.14706034
81MP0003787_abnormal_imprinting1.11836238
82MP0002722_abnormal_immune_system1.11644366
83MP0005334_abnormal_fat_pad1.09601421
84MP0000383_abnormal_hair_follicle1.08707538
85MP0000003_abnormal_adipose_tissue1.04999498
86MP0001661_extended_life_span1.04340146
87MP0003091_abnormal_cell_migration1.04144580
88MP0001845_abnormal_inflammatory_respons1.03884356
89MP0005164_abnormal_response_to1.03876679
90MP0003656_abnormal_erythrocyte_physiolo1.03090600
91MP0002078_abnormal_glucose_homeostasis1.01598719
92MP0004134_abnormal_chest_morphology1.01003807
93MP0008260_abnormal_autophagy0.99353484
94MP0002254_reproductive_system_inflammat0.99122721
95MP0002909_abnormal_adrenal_gland0.99013651
96MP0002419_abnormal_innate_immunity0.98352879
97MP0002168_other_aberrant_phenotype0.96698837
98MP0008877_abnormal_DNA_methylation0.95360787
99MP0003075_altered_response_to0.93901108
100MP0005409_darkened_coat_color0.91545338
101MP0009115_abnormal_fat_cell0.91507085
102MP0004947_skin_inflammation0.91026390
103MP0003633_abnormal_nervous_system0.90968147
104MP0002429_abnormal_blood_cell0.89078315
105MP0000013_abnormal_adipose_tissue0.85828242
106MP0010630_abnormal_cardiac_muscle0.84496010
107MP0000751_myopathy0.83332769
108MP0005448_abnormal_energy_balance0.81934170
109MP0002332_abnormal_exercise_endurance0.81531983
110MP0009763_increased_sensitivity_to0.79295732
111MP0003436_decreased_susceptibility_to0.78570271
112MP0009046_muscle_twitch0.78392034
113MP0003195_calcinosis0.78243663
114MP0001666_abnormal_nutrient_absorption0.78121977
115MP0002933_joint_inflammation0.78094729
116MP0000249_abnormal_blood_vessel0.77577231
117MP0005379_endocrine/exocrine_gland_phen0.76605452
118MP0002269_muscular_atrophy0.76406925
119MP0004087_abnormal_muscle_fiber0.76265347
120MP0002693_abnormal_pancreas_physiology0.76048522
121MP0005535_abnormal_body_temperature0.75823206
122MP0001873_stomach_inflammation0.75764565
123MP0002075_abnormal_coat/hair_pigmentati0.75137414
124MP0005167_abnormal_blood-brain_barrier0.75136282
125MP0010386_abnormal_urinary_bladder0.74837470
126MP0008875_abnormal_xenobiotic_pharmacok0.73087121
127MP0002877_abnormal_melanocyte_morpholog0.71667712
128MP0002148_abnormal_hypersensitivity_rea0.71182026
129MP0001958_emphysema0.71090413
130MP0004036_abnormal_muscle_relaxation0.69196055
131MP0002970_abnormal_white_adipose0.68101562
132MP0009672_abnormal_birth_weight0.67639103
133MP0005319_abnormal_enzyme/_coenzyme0.66850188
134MP0005220_abnormal_exocrine_pancreas0.66131537
135MP0002090_abnormal_vision0.66075944
136MP0008004_abnormal_stomach_pH0.65898331
137MP0000920_abnormal_myelination0.65583217
138MP0003221_abnormal_cardiomyocyte_apopto0.65304448
139MP0000598_abnormal_liver_morphology0.65301433
140MP0010352_gastrointestinal_tract_polyps0.65281454
141MP0004084_abnormal_cardiac_muscle0.64845482
142MP0003631_nervous_system_phenotype0.63809318
143MP0000427_abnormal_hair_cycle0.62746158
144MP0001324_abnormal_eye_pigmentation0.62190649
145MP0001545_abnormal_hematopoietic_system0.61789688
146MP0005397_hematopoietic_system_phenotyp0.61789688
147MP0010234_abnormal_vibrissa_follicle0.61255807
148MP0009703_decreased_birth_body0.60997490
149MP0003632_abnormal_nervous_system0.60578325
150MP0004215_abnormal_myocardial_fiber0.58935516
151MP0005584_abnormal_enzyme/coenzyme_acti0.57614274
152MP0001835_abnormal_antigen_presentation0.56055030
153MP0002998_abnormal_bone_remodeling0.55103134
154MP0000747_muscle_weakness0.53859251
155MP0001915_intracranial_hemorrhage0.52910107
156MP0005621_abnormal_cell_physiology0.52394525
157MP0005257_abnormal_intraocular_pressure0.49944398
158MP0002396_abnormal_hematopoietic_system0.49706609

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)4.57743572
2Abnormality of T cell number (HP:0011839)4.19823464
3Papillary thyroid carcinoma (HP:0002895)3.58712141
4Thyroiditis (HP:0100646)3.44689307
5Recurrent cutaneous fungal infections (HP:0011370)3.27660572
6Chronic mucocutaneous candidiasis (HP:0002728)3.27660572
7Recurrent fungal infections (HP:0002841)3.15757777
8Abnormality of the fingertips (HP:0001211)3.13398247
9Recurrent bronchitis (HP:0002837)3.04059616
10Abnormal delayed hypersensitivity skin test (HP:0002963)3.04043101
11Spontaneous hematomas (HP:0007420)2.99200335
12Cerebral aneurysm (HP:0004944)2.96673787
13Recurrent skin infections (HP:0001581)2.91915485
14Macroorchidism (HP:0000053)2.90673164
15Global brain atrophy (HP:0002283)2.87404109
16Narrow palate (HP:0000189)2.70991463
17Recurrent viral infections (HP:0004429)2.69659519
18Chronic diarrhea (HP:0002028)2.69408972
19Periodontitis (HP:0000704)2.69007563
20Myocardial infarction (HP:0001658)2.64777535
21Abnormality of T cells (HP:0002843)2.61048770
22Complement deficiency (HP:0004431)2.56811934
23Subacute progressive viral hepatitis (HP:0006572)2.54225124
24Hypoalphalipoproteinemia (HP:0003233)2.51576323
25Inflammation of the large intestine (HP:0002037)2.50562483
26Acute myeloid leukemia (HP:0004808)2.50165985
27Recurrent bacterial skin infections (HP:0005406)2.49782309
28Gastrointestinal infarctions (HP:0005244)2.49710915
29Urethral obstruction (HP:0000796)2.47489337
30Absent frontal sinuses (HP:0002688)2.47443778
31Viral hepatitis (HP:0006562)2.44003895
32Gaze-evoked nystagmus (HP:0000640)2.40793026
33Skin nodule (HP:0200036)2.39974206
34Deep venous thrombosis (HP:0002625)2.39066556
35Autoimmune hemolytic anemia (HP:0001890)2.38977024
36Thyroid carcinoma (HP:0002890)2.38895574
37Conjunctival telangiectasia (HP:0000524)2.36635982
38Abnormality of the vasculature of the conjunctiva (HP:0008054)2.36074975
39Heterotopia (HP:0002282)2.35411467
40Long toe (HP:0010511)2.34542421
41Joint hemorrhage (HP:0005261)2.34272075
42Widely spaced teeth (HP:0000687)2.33920964
43Stomatitis (HP:0010280)2.33254049
44Optic neuritis (HP:0100653)2.33064339
45Retrobulbar optic neuritis (HP:0100654)2.33064339
46Dysmetric saccades (HP:0000641)2.31939693
47Recurrent gram-negative bacterial infections (HP:0005420)2.30894164
48Gingivitis (HP:0000230)2.30290258
49Glucose intolerance (HP:0000833)2.29794046
50Autoimmune thrombocytopenia (HP:0001973)2.28133271
51Turricephaly (HP:0000262)2.25485374
52Papilledema (HP:0001085)2.25373236
53Epidermoid cyst (HP:0200040)2.24703473
54Panhypogammaglobulinemia (HP:0003139)2.24180035
55Increased cerebral lipofuscin (HP:0011813)2.21645305
56Hyperventilation (HP:0002883)2.21377938
57Fair hair (HP:0002286)2.20403836
58Xanthomatosis (HP:0000991)2.20088321
59Hypercholesterolemia (HP:0003124)2.20070983
60Aneurysm (HP:0002617)2.19518759
61Agammaglobulinemia (HP:0004432)2.16965012
62Recurrent abscess formation (HP:0002722)2.16954426
63Gastrointestinal inflammation (HP:0004386)2.16188398
64Abnormal glucose tolerance (HP:0001952)2.14874841
65Frequent falls (HP:0002359)2.14407301
66Distal lower limb amyotrophy (HP:0008944)2.14316247
67Myositis (HP:0100614)2.13081564
68Meningitis (HP:0001287)2.13034657
69Hemiplegia (HP:0002301)2.12872982
70Leukocytosis (HP:0001974)2.12497384
71Vasculitis (HP:0002633)2.11045747
72Gingival bleeding (HP:0000225)2.10893419
73Neoplasm of the tracheobronchial system (HP:0100552)2.10233660
74Generalized hypopigmentation of hair (HP:0011358)2.08893567
75Upper motor neuron abnormality (HP:0002127)2.07902436
76Menstrual irregularities (HP:0000858)2.07146547
77Chest pain (HP:0100749)2.06265240
78Abnormality of polysaccharide metabolism (HP:0011012)2.05980693
79Abnormality of glycosaminoglycan metabolism (HP:0004371)2.05980693
80Abnormality of mucopolysaccharide metabolism (HP:0011020)2.05980693
81Hypoglycemic seizures (HP:0002173)2.05761920
82Hematochezia (HP:0002573)2.05652867
83Degeneration of the lateral corticospinal tracts (HP:0002314)2.05510129
84Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.05510129
85Increased CSF protein (HP:0002922)2.05224316
86Hypoglycemic coma (HP:0001325)2.04302761
87Hand muscle atrophy (HP:0009130)2.04118381
88Mediastinal lymphadenopathy (HP:0100721)2.02224312
89IgA deficiency (HP:0002720)2.02147569
90Urinary bladder sphincter dysfunction (HP:0002839)2.01031137
91Neurodegeneration (HP:0002180)2.00795989
92Abnormality of eosinophils (HP:0001879)2.00624668
93Upper limb amyotrophy (HP:0009129)2.00520581
94Distal upper limb amyotrophy (HP:0007149)2.00520581
95Lower limb amyotrophy (HP:0007210)1.99998717
96Orchitis (HP:0100796)1.99564701
97Scanning speech (HP:0002168)1.99437877
98Abnormality of the thoracic spine (HP:0100711)1.98932425
99Overgrowth (HP:0001548)1.98880598
100Hemoptysis (HP:0002105)1.98606236
101Arterial thrombosis (HP:0004420)1.98279227
102Mitral stenosis (HP:0001718)1.97905722
103Hyperlipoproteinemia (HP:0010980)1.97875215
104Intrahepatic cholestasis (HP:0001406)1.94747577
105IgM deficiency (HP:0002850)1.94723122
106Drooling (HP:0002307)1.94196354
107Excessive salivation (HP:0003781)1.94196354
108Abnormality of the common coagulation pathway (HP:0010990)1.93310739
109Coarse hair (HP:0002208)1.92598320
110Hyperkalemia (HP:0002153)1.90796860
111Neonatal hypoglycemia (HP:0001998)1.89081005
112Stomach cancer (HP:0012126)1.88890935
113Blue irides (HP:0000635)1.88048313
114Genetic anticipation (HP:0003743)1.87845461
115Abnormality of vision evoked potentials (HP:0000649)1.87411685
116Truncal obesity (HP:0001956)1.86802637
117Eosinophilia (HP:0001880)1.85509819
118Osteomyelitis (HP:0002754)1.85298464
119Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.85160179
120Prolonged bleeding time (HP:0003010)1.84883795
121Generalized hypopigmentation (HP:0007513)1.84020292
122Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.83690547
123Severe combined immunodeficiency (HP:0004430)1.83263787
124Ketosis (HP:0001946)1.83113641
125Pulmonary infiltrates (HP:0002113)1.82001515
126Abnormality of macrophages (HP:0004311)1.81837355
127Bronchitis (HP:0012387)1.81525079
128Postural instability (HP:0002172)1.81296546
129Urinary glycosaminoglycan excretion (HP:0003541)1.80796601
130Mucopolysacchariduria (HP:0008155)1.80796601
131Hyperinsulinemic hypoglycemia (HP:0000825)1.80086459
132Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.79593263
133Thoracic kyphosis (HP:0002942)1.78930455
134Epistaxis (HP:0000421)1.78884648
135Focal seizures (HP:0007359)1.77933780
136Thoracolumbar scoliosis (HP:0002944)1.77487147
137Keratoconjunctivitis sicca (HP:0001097)1.75214265
138Mitral valve prolapse (HP:0001634)1.74988411
139Abnormality of the lower motor neuron (HP:0002366)1.74736440
140Hypochromic microcytic anemia (HP:0004840)1.74593359
141Systemic lupus erythematosus (HP:0002725)1.73708856
142Abnormality of complement system (HP:0005339)1.73614267
143Hypolipoproteinemia (HP:0010981)1.72521574
144Ocular albinism (HP:0001107)1.72400455
145Febrile seizures (HP:0002373)1.72046057
146Acute hepatic failure (HP:0006554)1.71674715
147Pulmonary embolism (HP:0002204)1.71511155
148Slow saccadic eye movements (HP:0000514)1.71492491
149Testicular neoplasm (HP:0010788)1.71393488
150Encephalitis (HP:0002383)1.70190966
151Dysostosis multiplex (HP:0000943)1.69391545
152Abnormality of secondary sexual hair (HP:0009888)1.69294385
153Abnormality of the axillary hair (HP:0100134)1.69294385
154Hyperglycemia (HP:0003074)1.69206479
155Colitis (HP:0002583)1.69173302
156Prominent nose (HP:0000448)1.68261236
157Aortic aneurysm (HP:0004942)1.65767349
158Thick nail (HP:0001805)1.65375599
159Striae distensae (HP:0001065)1.65096209
160Hyporeflexia of lower limbs (HP:0002600)1.64309116
161Submucous cleft hard palate (HP:0000176)1.62099650
162Difficulty running (HP:0009046)1.61918914
163Action tremor (HP:0002345)1.61529647
164Neuronal loss in central nervous system (HP:0002529)1.61144468
165Insulin-resistant diabetes mellitus (HP:0000831)1.61050965
166Acanthocytosis (HP:0001927)1.59939127
167Hypoplasia of the thymus (HP:0000778)1.59707482
168Obsessive-compulsive behavior (HP:0000722)1.59481383
169Abnormality of the astrocytes (HP:0100707)1.57082845
170Astrocytoma (HP:0009592)1.57082845
171Impaired smooth pursuit (HP:0007772)1.56718317
172Hypoplastic ischia (HP:0003175)1.56680315
173Abnormality of the periventricular white matter (HP:0002518)1.56118257
174Eczematoid dermatitis (HP:0000976)1.55645698
175Aplasia/Hypoplasia of the macula (HP:0008059)1.55450101
176Peripheral demyelination (HP:0011096)1.54559257
177Increased connective tissue (HP:0009025)1.54430751

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CAMK1D4.01050092
2CAMK1G3.54754032
3CDK123.02221234
4TAOK32.91710318
5BLK2.49674750
6RIPK12.28842279
7TTN2.26035253
8INSRR2.19895608
9TEC1.96989460
10AKT31.94287103
11SIK21.91085378
12PKN21.87021377
13SIK11.86107779
14NTRK31.86066095
15NLK1.84552661
16SGK31.80942758
17DAPK21.79744072
18PIK3CG1.75684842
19SGK21.68440026
20TXK1.65733902
21BTK1.65274347
22JAK11.64512392
23ACVR1B1.63946377
24TRIB31.62294428
25BRD41.60097665
26RIPK41.58498817
27MAP3K131.56278462
28IKBKE1.55767285
29SYK1.51983360
30BMPR21.46169499
31PTK61.38048615
32MAP3K71.35742292
33FRK1.26171840
34FES1.23377768
35TYK21.20643264
36SCYL21.20088953
37PDGFRB1.15809652
38PRKCH1.12670380
39FGFR31.11230014
40CDK61.09592433
41CAMKK11.08598374
42CAMKK21.06636403
43MTOR1.05054225
44JAK21.02460102
45YES11.02179395
46LATS11.00496711
47PDGFRA0.99780345
48STK380.99538836
49PRKAA20.96983613
50ZAP700.96495655
51PAK60.96382925
52EPHA30.96137749
53MAP3K20.95408998
54SGK10.94563349
55HCK0.93563190
56SGK4940.91187481
57SGK2230.91187481
58RET0.88613430
59LYN0.87978472
60FGFR40.87572723
61IRAK10.85961553
62MAP3K40.85518284
63FGFR20.85348846
64MAP3K140.84781314
65KIT0.84138885
66CAMK40.83536240
67STK240.82295244
68GRK60.81876838
69ERN10.80099397
70PRKD30.80079445
71FGR0.79916635
72FLT30.79737370
73CDC42BPA0.76943405
74PDK10.76360799
75MELK0.76087791
76MAP3K90.75235545
77OBSCN0.75124735
78PRKAA10.74897367
79NEK60.74623097
80PIK3CA0.74134732
81HIPK20.73301394
82PDPK10.73221582
83PTK2B0.71719366
84PAK30.71398129
85LMTK20.71382803
86WNK10.71324916
87PTK20.70451279
88KSR20.69265236
89IRAK40.68971468
90DMPK0.68107903
91MARK20.66901676
92JAK30.66656875
93MAP3K10.65469938
94MAP3K100.65251207
95CSF1R0.63951905
96CDK90.61640395
97MAP2K40.61479678
98TNK20.61432622
99BMX0.60138251
100FER0.60094497
101RPS6KA20.58212153
102NEK90.57304888
103PIM10.57226404
104IKBKB0.56848568
105TRPM70.56809291
106ICK0.56404296
107MAPK100.56350139
108PRPF4B0.56278619
109EGFR0.55628042
110CAMK10.54243280
111RPS6KA30.54115393
112ITK0.53324795
113PRKCQ0.53038597
114MAP2K30.52646009
115TGFBR20.51267300
116ERBB30.50176123
117RPS6KB10.49896635
118MAPK110.49624212
119STK110.48614819
120MARK30.47816362
121MAPK70.47545320
122ERBB20.46636725
123MAP4K10.45945117
124CSK0.45927977
125DYRK1A0.44996940
126MST1R0.43899334
127BMPR1B0.43836349
128EIF2AK30.43731072
129STK30.43211864
130STK38L0.43102743
131FYN0.42957003
132PRKD10.42784954
133MAP3K60.42685722
134MAPK120.41663278
135EPHA40.41657647
136CHUK0.40554643
137ALK0.40390962
138LCK0.39888431
139PRKDC0.39487181
140SRC0.38253618

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.30190160
2Type II diabetes mellitus_Homo sapiens_hsa049302.23743276
3Lysine degradation_Homo sapiens_hsa003102.22958771
4Caffeine metabolism_Homo sapiens_hsa002321.79755348
5Leishmaniasis_Homo sapiens_hsa051401.77539290
6Staphylococcus aureus infection_Homo sapiens_hsa051501.68304903
7T cell receptor signaling pathway_Homo sapiens_hsa046601.64508070
8Arginine biosynthesis_Homo sapiens_hsa002201.61115773
9ABC transporters_Homo sapiens_hsa020101.59688257
10Primary bile acid biosynthesis_Homo sapiens_hsa001201.58617245
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.56573437
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.54461958
13Complement and coagulation cascades_Homo sapiens_hsa046101.52161725
14PPAR signaling pathway_Homo sapiens_hsa033201.47853736
15Jak-STAT signaling pathway_Homo sapiens_hsa046301.44145812
16Phosphatidylinositol signaling system_Homo sapiens_hsa040701.43119533
17Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.42232842
18Graft-versus-host disease_Homo sapiens_hsa053321.41097845
19Allograft rejection_Homo sapiens_hsa053301.39372302
20Measles_Homo sapiens_hsa051621.38441467
21Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.37929087
22Primary immunodeficiency_Homo sapiens_hsa053401.37870012
23Fatty acid degradation_Homo sapiens_hsa000711.37728924
24Type I diabetes mellitus_Homo sapiens_hsa049401.36700955
25Insulin resistance_Homo sapiens_hsa049311.35046478
26Autoimmune thyroid disease_Homo sapiens_hsa053201.34988983
27Fatty acid biosynthesis_Homo sapiens_hsa000611.27835303
28NF-kappa B signaling pathway_Homo sapiens_hsa040641.27311459
29Prolactin signaling pathway_Homo sapiens_hsa049171.26851964
30mTOR signaling pathway_Homo sapiens_hsa041501.25835576
31Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.25732287
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.25176661
33Bile secretion_Homo sapiens_hsa049761.24947478
34NOD-like receptor signaling pathway_Homo sapiens_hsa046211.20752492
35Intestinal immune network for IgA production_Homo sapiens_hsa046721.20491716
36Carbohydrate digestion and absorption_Homo sapiens_hsa049731.16477429
37Fatty acid metabolism_Homo sapiens_hsa012121.15843272
38AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.14508297
39Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.11800798
40Asthma_Homo sapiens_hsa053101.11630715
41Aldosterone synthesis and secretion_Homo sapiens_hsa049251.10572545
42Hematopoietic cell lineage_Homo sapiens_hsa046401.07672352
43RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.06784261
44Circadian rhythm_Homo sapiens_hsa047101.03864710
45Dorso-ventral axis formation_Homo sapiens_hsa043201.03698288
46Insulin signaling pathway_Homo sapiens_hsa049101.03326224
47Adipocytokine signaling pathway_Homo sapiens_hsa049201.02797372
48Influenza A_Homo sapiens_hsa051641.01141119
49Glucagon signaling pathway_Homo sapiens_hsa049220.99796117
50Inositol phosphate metabolism_Homo sapiens_hsa005620.98850642
51Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.97361600
52Osteoclast differentiation_Homo sapiens_hsa043800.95972566
53Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.94877241
54Insulin secretion_Homo sapiens_hsa049110.94786711
55Longevity regulating pathway - mammal_Homo sapiens_hsa042110.93468115
56Renal cell carcinoma_Homo sapiens_hsa052110.93385320
57Glycerolipid metabolism_Homo sapiens_hsa005610.92648753
58Leukocyte transendothelial migration_Homo sapiens_hsa046700.92448356
59TNF signaling pathway_Homo sapiens_hsa046680.91826909
60Hepatitis B_Homo sapiens_hsa051610.91257357
61Circadian entrainment_Homo sapiens_hsa047130.88486465
62Tryptophan metabolism_Homo sapiens_hsa003800.88320524
63Lysosome_Homo sapiens_hsa041420.88209602
64Long-term potentiation_Homo sapiens_hsa047200.87944759
65Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.87037869
66Glycosaminoglycan degradation_Homo sapiens_hsa005310.85884436
67Long-term depression_Homo sapiens_hsa047300.85808597
68Glioma_Homo sapiens_hsa052140.85568987
69Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.84629614
70Sphingolipid signaling pathway_Homo sapiens_hsa040710.84484725
71Starch and sucrose metabolism_Homo sapiens_hsa005000.83563826
72Hepatitis C_Homo sapiens_hsa051600.82920544
73Renin secretion_Homo sapiens_hsa049240.81706356
74Prostate cancer_Homo sapiens_hsa052150.81606191
75Salivary secretion_Homo sapiens_hsa049700.80268688
76Propanoate metabolism_Homo sapiens_hsa006400.80247911
77Dilated cardiomyopathy_Homo sapiens_hsa054140.79304752
78AMPK signaling pathway_Homo sapiens_hsa041520.79260103
79Thyroid hormone signaling pathway_Homo sapiens_hsa049190.79052944
80Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.77449826
81Morphine addiction_Homo sapiens_hsa050320.75278134
82Colorectal cancer_Homo sapiens_hsa052100.74403275
83Chronic myeloid leukemia_Homo sapiens_hsa052200.73442693
84Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.73169422
85B cell receptor signaling pathway_Homo sapiens_hsa046620.73039620
86Antigen processing and presentation_Homo sapiens_hsa046120.72809202
87Vascular smooth muscle contraction_Homo sapiens_hsa042700.72118868
88VEGF signaling pathway_Homo sapiens_hsa043700.71498132
89Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.71335847
90Estrogen signaling pathway_Homo sapiens_hsa049150.70931458
91GnRH signaling pathway_Homo sapiens_hsa049120.70724646
92Malaria_Homo sapiens_hsa051440.70671267
93cAMP signaling pathway_Homo sapiens_hsa040240.70214120
94Phospholipase D signaling pathway_Homo sapiens_hsa040720.70208823
95cGMP-PKG signaling pathway_Homo sapiens_hsa040220.69344854
96Other glycan degradation_Homo sapiens_hsa005110.69000336
97Regulation of autophagy_Homo sapiens_hsa041400.67619564
98Central carbon metabolism in cancer_Homo sapiens_hsa052300.67433585
99Transcriptional misregulation in cancer_Homo sapiens_hsa052020.66980912
100Glutamatergic synapse_Homo sapiens_hsa047240.66424416
101Gastric acid secretion_Homo sapiens_hsa049710.65586715
102Herpes simplex infection_Homo sapiens_hsa051680.65500983
103Cholinergic synapse_Homo sapiens_hsa047250.64742124
104Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.64551804
105Nicotine addiction_Homo sapiens_hsa050330.63813457
106Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.63243862
107Viral myocarditis_Homo sapiens_hsa054160.62715730
108Olfactory transduction_Homo sapiens_hsa047400.62652895
109Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.62598819
110Maturity onset diabetes of the young_Homo sapiens_hsa049500.61968147
111Calcium signaling pathway_Homo sapiens_hsa040200.61906298
112Oxytocin signaling pathway_Homo sapiens_hsa049210.61557651
113Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.61072833
114Non-small cell lung cancer_Homo sapiens_hsa052230.60351386
115Neurotrophin signaling pathway_Homo sapiens_hsa047220.59696513
116Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.59660946
117Synaptic vesicle cycle_Homo sapiens_hsa047210.59464266
118Choline metabolism in cancer_Homo sapiens_hsa052310.58687138
119Tuberculosis_Homo sapiens_hsa051520.58510468
120Platelet activation_Homo sapiens_hsa046110.58427282
121GABAergic synapse_Homo sapiens_hsa047270.58154622
122MAPK signaling pathway_Homo sapiens_hsa040100.56193770
123Butanoate metabolism_Homo sapiens_hsa006500.55907274
124Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.55672629
125HIF-1 signaling pathway_Homo sapiens_hsa040660.55637167
126Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.54648685
127Toll-like receptor signaling pathway_Homo sapiens_hsa046200.52882105
128Selenocompound metabolism_Homo sapiens_hsa004500.52829904
129Ras signaling pathway_Homo sapiens_hsa040140.52477365
130Small cell lung cancer_Homo sapiens_hsa052220.51757564
131Amoebiasis_Homo sapiens_hsa051460.51649801
132Phagosome_Homo sapiens_hsa041450.50846961
1332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.50749680
134Pancreatic secretion_Homo sapiens_hsa049720.50396724
135Proteoglycans in cancer_Homo sapiens_hsa052050.50391563
136Legionellosis_Homo sapiens_hsa051340.50232499
137Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.49759974
138African trypanosomiasis_Homo sapiens_hsa051430.49071490
139Acute myeloid leukemia_Homo sapiens_hsa052210.47887888
140Endometrial cancer_Homo sapiens_hsa052130.47688457
141ErbB signaling pathway_Homo sapiens_hsa040120.47500477
142Thyroid hormone synthesis_Homo sapiens_hsa049180.47035988
143Pancreatic cancer_Homo sapiens_hsa052120.46717511
144beta-Alanine metabolism_Homo sapiens_hsa004100.46195913
145Focal adhesion_Homo sapiens_hsa045100.45287903
146Chemokine signaling pathway_Homo sapiens_hsa040620.45015268
147FoxO signaling pathway_Homo sapiens_hsa040680.44852766
148Peroxisome_Homo sapiens_hsa041460.44546465
149Toxoplasmosis_Homo sapiens_hsa051450.42234392

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