VPS13D

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein belonging to the vacuolar-protein-sorting-13 gene family. In yeast, vacuolar-protein-sorting-13 proteins are involved in trafficking of membrane proteins between the trans-Golgi network and the prevacuolar compartment. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode distinct isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1phospholipid homeostasis (GO:0055091)4.24047764
2dicarboxylic acid biosynthetic process (GO:0043650)3.48303283
3macroautophagy (GO:0016236)3.36729341
4interkinetic nuclear migration (GO:0022027)3.28783385
5carnitine shuttle (GO:0006853)3.26492195
6phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.26231976
7fatty acid transmembrane transport (GO:1902001)3.25134867
8cytoskeletal anchoring at plasma membrane (GO:0007016)3.20359455
9regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.18748802
10histone H3-K36 demethylation (GO:0070544)3.13544337
11positive regulation of fatty acid beta-oxidation (GO:0032000)3.02923369
12nucleus localization (GO:0051647)3.02819999
13urea metabolic process (GO:0019627)2.98589546
14urea cycle (GO:0000050)2.98589546
15negative regulation of myotube differentiation (GO:0010832)2.95999164
16cellular response to epinephrine stimulus (GO:0071872)2.95742776
17fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.92159343
18establishment of nucleus localization (GO:0040023)2.91770963
19regulation of sequestering of triglyceride (GO:0010889)2.88461809
20desmosome organization (GO:0002934)2.85685401
21alpha-linolenic acid metabolic process (GO:0036109)2.85624397
22histone H3-K9 demethylation (GO:0033169)2.84281961
23insulin-like growth factor receptor signaling pathway (GO:0048009)2.83507249
24histone H3-K4 trimethylation (GO:0080182)2.82652566
25positive regulation of gamma-delta T cell activation (GO:0046645)2.80595415
26myofibril assembly (GO:0030239)2.79759679
27regulation of NFAT protein import into nucleus (GO:0051532)2.76955229
28skeletal muscle adaptation (GO:0043501)2.76851832
29lipoprotein transport (GO:0042953)2.75255461
30growth hormone receptor signaling pathway (GO:0060396)2.74323660
31hemidesmosome assembly (GO:0031581)2.74268043
32establishment of protein localization to Golgi (GO:0072600)2.74014708
33cell-substrate junction assembly (GO:0007044)2.70210746
34response to epinephrine (GO:0071871)2.69287911
35retrograde transport, vesicle recycling within Golgi (GO:0000301)2.67769410
36phospholipid translocation (GO:0045332)2.67299935
37lipid translocation (GO:0034204)2.67299935
38peptidyl-threonine phosphorylation (GO:0018107)2.66926982
39regulation of ARF protein signal transduction (GO:0032012)2.66540403
40positive regulation of fatty acid oxidation (GO:0046321)2.64878391
41cytoplasmic mRNA processing body assembly (GO:0033962)2.64218050
42positive regulation of lipid catabolic process (GO:0050996)2.63133744
43positive regulation of cellular amide metabolic process (GO:0034250)2.62612870
44regulation of fatty acid beta-oxidation (GO:0031998)2.61911770
45import into cell (GO:0098657)2.59843779
46cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.59728035
47nitrogen cycle metabolic process (GO:0071941)2.58918382
48positive regulation of p38MAPK cascade (GO:1900745)2.58248419
49triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.58145244
50nerve growth factor signaling pathway (GO:0038180)2.56024019
51carnitine transmembrane transport (GO:1902603)2.55980453
52protein targeting to Golgi (GO:0000042)2.55910787
53striated muscle atrophy (GO:0014891)2.55865584
54cardiac myofibril assembly (GO:0055003)2.54328997
55peptidyl-threonine modification (GO:0018210)2.53380378
56regulation of cholesterol storage (GO:0010885)2.52171018
57regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.52072782
58I-kappaB phosphorylation (GO:0007252)2.52070513
59negative regulation of erythrocyte differentiation (GO:0045647)2.51197589
60homocysteine metabolic process (GO:0050667)2.50908385
61cellular response to growth hormone stimulus (GO:0071378)2.50110621
62Golgi to endosome transport (GO:0006895)2.49755472
63establishment of skin barrier (GO:0061436)2.49414906
64iron ion import (GO:0097286)2.47230382
65interleukin-6-mediated signaling pathway (GO:0070102)2.45643140
66hypotonic response (GO:0006971)2.45156490
67carnitine transport (GO:0015879)2.43545065
68amino-acid betaine transport (GO:0015838)2.43545065
69positive regulation of Rap GTPase activity (GO:0032854)2.43446162
70L-amino acid import (GO:0043092)2.42710449
71phospholipid efflux (GO:0033700)2.41971304
72positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.40154416
73response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.39835410
74regulation of triglyceride catabolic process (GO:0010896)2.39124046
75embryonic process involved in female pregnancy (GO:0060136)2.38894816
76antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.38742208
77lysine metabolic process (GO:0006553)2.37383246
78lysine catabolic process (GO:0006554)2.37383246
79negative regulation of cell killing (GO:0031342)2.37336983
80negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.37336983
81regulation of cholesterol homeostasis (GO:2000188)2.36886787
82negative regulation of potassium ion transmembrane transport (GO:1901380)2.36647686
83low-density lipoprotein particle clearance (GO:0034383)2.36202836
84coronary vasculature morphogenesis (GO:0060977)2.35750759
85negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.34712863
86histone lysine demethylation (GO:0070076)2.34545273
87nuclear pore complex assembly (GO:0051292)2.34522754
88negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.34394606
89relaxation of cardiac muscle (GO:0055119)2.33314369
90sarcoplasmic reticulum calcium ion transport (GO:0070296)2.32168349
91regulation of fatty acid oxidation (GO:0046320)2.32014833
92negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.31769034
93kynurenine metabolic process (GO:0070189)2.31306714
94cell-substrate adherens junction assembly (GO:0007045)2.31060869
95focal adhesion assembly (GO:0048041)2.31060869
96regulation of nucleobase-containing compound transport (GO:0032239)2.30495221
97positive regulation of cholesterol efflux (GO:0010875)2.30449523
98plasma lipoprotein particle assembly (GO:0034377)2.29686410
99complement activation, alternative pathway (GO:0006957)2.29658702
100plasma lipoprotein particle clearance (GO:0034381)2.29645941
101regulation of p38MAPK cascade (GO:1900744)2.29233380
102regulation of water loss via skin (GO:0033561)2.28703817
103regulation of gamma-delta T cell activation (GO:0046643)2.28402402
104alanine transport (GO:0032328)2.28098887
105regulation of histone H3-K27 methylation (GO:0061085)2.27725483
106regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.27582286
107cerebellar Purkinje cell differentiation (GO:0021702)2.26465086
1082-oxoglutarate metabolic process (GO:0006103)2.26349706
109embryonic retina morphogenesis in camera-type eye (GO:0060059)2.26336169
110regulation of gamma-delta T cell differentiation (GO:0045586)2.26261777
111ventricular cardiac muscle cell action potential (GO:0086005)2.25924106
112vesicle transport along microtubule (GO:0047496)2.25889754
113activation of protein kinase A activity (GO:0034199)2.24480976
114positive regulation of cholesterol transport (GO:0032376)2.24074738
115positive regulation of sterol transport (GO:0032373)2.24074738
116regulation of skeletal muscle cell differentiation (GO:2001014)2.23387384
117sodium ion export (GO:0071436)2.23157097
118intracellular lipid transport (GO:0032365)2.22423752
119regulation of relaxation of muscle (GO:1901077)2.22115028
120cholesterol efflux (GO:0033344)2.21736116
121positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.21534659
122regulation of RNA export from nucleus (GO:0046831)2.21299494
123positive regulation of glycolytic process (GO:0045821)2.21271406
124histone demethylation (GO:0016577)2.21260233
125regulation of Rap GTPase activity (GO:0032317)2.21245117
126cell communication involved in cardiac conduction (GO:0086065)2.20232302
127cardiac muscle contraction (GO:0060048)2.20004443
128adherens junction assembly (GO:0034333)2.19990557
129bundle of His cell to Purkinje myocyte communication (GO:0086069)2.19955624
130positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.19232635
131fatty acid beta-oxidation (GO:0006635)2.19229458
132protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.17864949
133regulation of actin filament-based movement (GO:1903115)2.17740440
134protein-lipid complex assembly (GO:0065005)2.17300528
135positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.16946391
136fibroblast migration (GO:0010761)2.16867702
137cardiac muscle hypertrophy (GO:0003300)2.16006553
138positive regulation of histone deacetylation (GO:0031065)2.14239164
139plasma membrane repair (GO:0001778)2.14086818
140reverse cholesterol transport (GO:0043691)2.13881419
141cell communication by electrical coupling (GO:0010644)2.13738493
142regulation of beta-amyloid formation (GO:1902003)2.13580508
143regulation of protein polyubiquitination (GO:1902914)2.13435504
144L-phenylalanine catabolic process (GO:0006559)2.12735903
145erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.12735903
146tryptophan metabolic process (GO:0006568)2.12728777
147modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.12704554
148positive regulation by organism of defense response of other organism involved in symbiotic interact2.12704554
149modulation by symbiont of host immune response (GO:0052553)2.12704554
150positive regulation by symbiont of host defense response (GO:0052509)2.12704554
151modulation by symbiont of host defense response (GO:0052031)2.12704554
152modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.12704554
153aromatic amino acid family catabolic process (GO:0009074)2.12193292
154indole-containing compound catabolic process (GO:0042436)2.11904742
155indolalkylamine catabolic process (GO:0046218)2.11904742
156tryptophan catabolic process (GO:0006569)2.11904742
157regulation of necroptotic process (GO:0060544)2.11859101
158glucan catabolic process (GO:0009251)2.11829093
159synaptic vesicle docking involved in exocytosis (GO:0016081)2.11821296
160valine metabolic process (GO:0006573)2.11763824
161regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.11378335
162positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.11067259
163striated muscle adaptation (GO:0014888)2.10684165
164phospholipid dephosphorylation (GO:0046839)2.10140180
165regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.10103291
166regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.09926535
167negative regulation of lipase activity (GO:0060192)2.08766681
168negative regulation of lipid storage (GO:0010888)2.07117045
169muscle atrophy (GO:0014889)2.06788933
170diacylglycerol metabolic process (GO:0046339)2.06694645
171negative regulation of fatty acid transport (GO:2000192)2.06523409
172actomyosin structure organization (GO:0031032)2.05931826
173peptidyl-serine phosphorylation (GO:0018105)2.05825613
174neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.05488710
175cellular response to ethanol (GO:0071361)2.05446562
176striated muscle hypertrophy (GO:0014897)2.05388899
177fatty acid homeostasis (GO:0055089)2.05134760
178cellular response to catecholamine stimulus (GO:0071870)2.04835274

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.78227725
2* LXR_22158963_ChIP-Seq_LIVER_Mouse2.40196498
3RXR_22158963_ChIP-Seq_LIVER_Mouse2.37073397
4* NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.35963833
5TP63_17297297_ChIP-ChIP_HaCaT_Human2.28005171
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.09223872
7DROSHA_22980978_ChIP-Seq_HELA_Human2.04614515
8GATA1_22025678_ChIP-Seq_K562_Human1.98728604
9* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.95852729
10Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.83978706
11CDX2_19796622_ChIP-Seq_MESCs_Mouse1.79832249
12FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.75611019
13IRF8_22096565_ChIP-ChIP_GC-B_Human1.75447659
14GBX2_23144817_ChIP-Seq_PC3_Human1.71788553
15VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.71648434
16SMAD_19615063_ChIP-ChIP_OVARY_Human1.71499708
17NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.70327796
18BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.70074260
19ZNF217_24962896_ChIP-Seq_MCF-7_Human1.69724988
20* FOXA2_19822575_ChIP-Seq_HepG2_Human1.62457637
21IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.51341445
22ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.48446564
23* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.46315414
24PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.45618991
25SCL_19346495_ChIP-Seq_HPC-7_Human1.45317541
26TP53_16413492_ChIP-PET_HCT116_Human1.44286980
27BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.43505601
28GATA2_21666600_ChIP-Seq_HMVEC_Human1.38136674
29* AHR_22903824_ChIP-Seq_MCF-7_Human1.37638942
30ESR2_21235772_ChIP-Seq_MCF-7_Human1.34574837
31* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.33687336
32EGR1_23403033_ChIP-Seq_LIVER_Mouse1.32905322
33SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.32084883
34EGR1_19374776_ChIP-ChIP_THP-1_Human1.29613692
35* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.29501087
36FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.29328710
37TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.28216724
38ESR1_20079471_ChIP-ChIP_T-47D_Human1.27701463
39ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.26510966
40* ARNT_22903824_ChIP-Seq_MCF-7_Human1.26040580
41CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.24551898
42STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.23820145
43PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.23783097
44RUNX_20019798_ChIP-Seq_JUKART_Human1.23062818
45EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.19843435
46YAP1_20516196_ChIP-Seq_MESCs_Mouse1.19358137
47* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19268368
48EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.18801528
49EP300_21415370_ChIP-Seq_HL-1_Mouse1.18652804
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.18640726
51FOXO3_23340844_ChIP-Seq_DLD1_Human1.17521640
52SMAD4_21799915_ChIP-Seq_A2780_Human1.16966662
53PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.16240646
54IRF8_27001747_Chip-Seq_BMDM_Mouse1.14165897
55AR_21572438_ChIP-Seq_LNCaP_Human1.13060836
56PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.12119275
57STAT3_23295773_ChIP-Seq_U87_Human1.11195280
58* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.11037707
59RXR_22108803_ChIP-Seq_LS180_Human1.10906842
60RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10838778
61ESR1_21235772_ChIP-Seq_MCF-7_Human1.10702625
62PPAR_26484153_Chip-Seq_NCI-H1993_Human1.10635481
63VDR_24787735_ChIP-Seq_THP-1_Human1.10110922
64* TCF7_22412390_ChIP-Seq_EML_Mouse1.09418870
65TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.09241954
66* SPI1_23127762_ChIP-Seq_K562_Human1.08614506
67GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.08330612
68SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.05766556
69SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.05766556
70MYB_21317192_ChIP-Seq_ERMYB_Mouse1.05217721
71THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.04265806
72SOX9_24532713_ChIP-Seq_HFSC_Mouse1.04001808
73KDM2B_26808549_Chip-Seq_SUP-B15_Human1.03948052
74ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03174922
75GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01606296
76NFIB_24661679_ChIP-Seq_LUNG_Mouse1.01044482
77TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.01029118
78* TBX20_22328084_ChIP-Seq_HEART_Mouse1.00961436
79* TBX20_22080862_ChIP-Seq_HEART_Mouse1.00961436
80SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.00954307
81* SOX2_21211035_ChIP-Seq_LN229_Gbm1.00762942
82* TP63_23658742_ChIP-Seq_EP156T_Human0.99575564
83FOXM1_26456572_ChIP-Seq_MCF-7_Human0.99509099
84NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.98514119
85AR_19668381_ChIP-Seq_PC3_Human0.98393621
86RUNX1_27514584_Chip-Seq_MCF-7_Human0.97345392
87BCAT_22108803_ChIP-Seq_LS180_Human0.97158930
88* TCF4_23295773_ChIP-Seq_U87_Human0.95211174
89* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.95192413
90FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.95121350
91TCF4_18268006_ChIP-ChIP_LS174T_Human0.95055711
92KDM2B_26808549_Chip-Seq_JURKAT_Human0.94692766
93* GATA2_19941826_ChIP-Seq_K562_Human0.94406737
94SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.94007251
95GATA1_19941827_ChIP-Seq_MEL86_Mouse0.93521288
96* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.93044576
97* GATA1_19941826_ChIP-Seq_K562_Human0.92883472
98CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.92252761
99* GATA1_19941827_ChIP-Seq_MEL_Mouse0.92133591
100GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91846554
101EZH2_22144423_ChIP-Seq_EOC_Human0.91778143
102CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.91526568
103SMAD4_21741376_ChIP-Seq_HESCs_Human0.91496190
104NR3C1_23031785_ChIP-Seq_PC12_Mouse0.91402011
105* SMAD3_21741376_ChIP-Seq_HESCs_Human0.91319065
106TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.91266162
107WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.90974287
108* KDM2B_26808549_Chip-Seq_K562_Human0.90458021
109RARB_27405468_Chip-Seq_BRAIN_Mouse0.89975588
110MTF2_20144788_ChIP-Seq_MESCs_Mouse0.89926536
111NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.89036587
112NRF2_20460467_ChIP-Seq_MEFs_Mouse0.89036587
113DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.85727415
114AR_25329375_ChIP-Seq_VCAP_Human0.85659634
115SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.85223926
116FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.85135969
117TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.84692155
118* STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.84218125
119AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.83988284
120SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.83405053
121NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.81512351
122* HNF4A_19822575_ChIP-Seq_HepG2_Human0.81388148
123FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.80826057
124PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.80250723

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation6.21711331
2MP0005360_urolithiasis3.99370876
3MP0002139_abnormal_hepatobiliary_system3.65449473
4MP0005365_abnormal_bile_salt3.19029605
5MP0003252_abnormal_bile_duct2.91928245
6MP0005409_darkened_coat_color2.84618247
7MP0005085_abnormal_gallbladder_physiolo2.82317494
8MP0004130_abnormal_muscle_cell2.75373412
9MP0005275_abnormal_skin_tensile2.70625222
10MP0002009_preneoplasia2.47430830
11MP0002837_dystrophic_cardiac_calcinosis2.41146984
12MP0005670_abnormal_white_adipose2.37115868
13MP0004510_myositis2.31337476
14MP0003045_fibrosis2.29166088
15MP0010329_abnormal_lipoprotein_level2.25501319
16MP0003300_gastrointestinal_ulcer2.21453700
17MP0010352_gastrointestinal_tract_polyps2.08171135
18MP0003172_abnormal_lysosome_physiology2.02396910
19MP0008057_abnormal_DNA_replication1.96715214
20MP0003191_abnormal_cellular_cholesterol1.85893608
21MP0009780_abnormal_chondrocyte_physiolo1.82020240
22MP0002166_altered_tumor_susceptibility1.79992871
23MP0008875_abnormal_xenobiotic_pharmacok1.79450836
24MP0000751_myopathy1.79076534
25MP0005451_abnormal_body_composition1.76772099
26MP0004233_abnormal_muscle_weight1.70100133
27MP0003646_muscle_fatigue1.68711438
28MP0005666_abnormal_adipose_tissue1.67693378
29MP0004859_abnormal_synaptic_plasticity1.64952460
30MP0008961_abnormal_basal_metabolism1.62782678
31MP0003763_abnormal_thymus_physiology1.61427551
32MP0004381_abnormal_hair_follicle1.58789488
33MP0004215_abnormal_myocardial_fiber1.54746635
34MP0002254_reproductive_system_inflammat1.53426696
35MP0006138_congestive_heart_failure1.51069609
36MP0003329_amyloid_beta_deposits1.50231722
37MP0002118_abnormal_lipid_homeostasis1.49827024
38MP0005083_abnormal_biliary_tract1.49183085
39MP0003453_abnormal_keratinocyte_physiol1.48768204
40MP0003690_abnormal_glial_cell1.47996679
41MP0003183_abnormal_peptide_metabolism1.47424325
42MP0000609_abnormal_liver_physiology1.44780386
43MP0003705_abnormal_hypodermis_morpholog1.41769259
44MP0002796_impaired_skin_barrier1.41515588
45MP0001666_abnormal_nutrient_absorption1.40584670
46MP0000383_abnormal_hair_follicle1.40521149
47MP0009840_abnormal_foam_cell1.37121367
48MP0000747_muscle_weakness1.36995114
49MP0005058_abnormal_lysosome_morphology1.35575684
50MP0001851_eye_inflammation1.35067764
51MP0010678_abnormal_skin_adnexa1.33055513
52MP0002138_abnormal_hepatobiliary_system1.31015406
53MP0000759_abnormal_skeletal_muscle1.29501965
54MP0000733_abnormal_muscle_development1.28479019
55MP0003950_abnormal_plasma_membrane1.27416918
56MP0005167_abnormal_blood-brain_barrier1.27254381
57MP0005023_abnormal_wound_healing1.26160420
58MP0004084_abnormal_cardiac_muscle1.24818592
59MP0008438_abnormal_cutaneous_collagen1.24641170
60MP0002971_abnormal_brown_adipose1.24588714
61MP0002006_tumorigenesis1.22991740
62MP0004264_abnormal_extraembryonic_tissu1.22690001
63MP0000604_amyloidosis1.21830481
64MP0004185_abnormal_adipocyte_glucose1.21361473
65MP0005174_abnormal_tail_pigmentation1.20906915
66MP0010368_abnormal_lymphatic_system1.20614417
67MP0000371_diluted_coat_color1.19914765
68MP0002108_abnormal_muscle_morphology1.19519416
69MP0002928_abnormal_bile_duct1.17511961
70MP0003868_abnormal_feces_composition1.13143045
71MP0002877_abnormal_melanocyte_morpholog1.12738688
72MP0004087_abnormal_muscle_fiber1.12481987
73MP0005375_adipose_tissue_phenotype1.10528969
74MP0008260_abnormal_autophagy1.10473277
75MP0004808_abnormal_hematopoietic_stem1.10386756
76MP0002168_other_aberrant_phenotype1.07615581
77MP0005535_abnormal_body_temperature1.06901626
78MP0004270_analgesia1.06853902
79MP0004036_abnormal_muscle_relaxation1.06650049
80MP0010630_abnormal_cardiac_muscle1.06509734
81MP0005330_cardiomyopathy1.05701836
82MP0008004_abnormal_stomach_pH1.05677810
83MP0004145_abnormal_muscle_electrophysio1.05479447
84MP0003303_peritoneal_inflammation1.04135335
85MP0005334_abnormal_fat_pad1.03259353
86MP0008775_abnormal_heart_ventricle1.02476822
87MP0002106_abnormal_muscle_physiology1.01328137
88MP0002060_abnormal_skin_morphology1.01285251
89MP0009046_muscle_twitch1.00033678
90MP0000579_abnormal_nail_morphology0.99781155
91MP0005332_abnormal_amino_acid0.98258479
92MP0001915_intracranial_hemorrhage0.95937806
93MP0003632_abnormal_nervous_system0.95213826
94MP0002909_abnormal_adrenal_gland0.94725450
95MP0001879_abnormal_lymphatic_vessel0.94216948
96MP0003879_abnormal_hair_cell0.94067038
97MP0002078_abnormal_glucose_homeostasis0.92080754
98MP0002998_abnormal_bone_remodeling0.90696596
99MP0005388_respiratory_system_phenotype0.90439307
100MP0002133_abnormal_respiratory_system0.90439307
101MP0004484_altered_response_of0.89388406
102MP0009278_abnormal_bone_marrow0.89320767
103MP0005464_abnormal_platelet_physiology0.89277695
104MP0005448_abnormal_energy_balance0.88401594
105MP0004947_skin_inflammation0.87435420
106MP0003633_abnormal_nervous_system0.87322799
107MP0005369_muscle_phenotype0.86872667
108MP0000920_abnormal_myelination0.86113299
109MP0001958_emphysema0.85436149
110MP0000465_gastrointestinal_hemorrhage0.83753428
111MP0005584_abnormal_enzyme/coenzyme_acti0.83213554
112MP0005319_abnormal_enzyme/_coenzyme0.82588310
113MP0003279_aneurysm0.82442719
114MP0002972_abnormal_cardiac_muscle0.82396658
115MP0003091_abnormal_cell_migration0.82369596
116MP0002269_muscular_atrophy0.81648232
117MP0003566_abnormal_cell_adhesion0.81386376
118MP0008569_lethality_at_weaning0.80770145
119MP0001501_abnormal_sleep_pattern0.80237349
120MP0010234_abnormal_vibrissa_follicle0.79613139
121MP0005621_abnormal_cell_physiology0.79233010
122MP0009763_increased_sensitivity_to0.78437480
123MP0009764_decreased_sensitivity_to0.77920192
124MP0000015_abnormal_ear_pigmentation0.77146201
125MP0009115_abnormal_fat_cell0.76765364
126MP0005076_abnormal_cell_differentiation0.76521299
127MP0002332_abnormal_exercise_endurance0.76516835
128MP0004272_abnormal_basement_membrane0.76393712
129MP0000749_muscle_degeneration0.76301638
130MP0003828_pulmonary_edema0.75612539
131MP0003075_altered_response_to0.74912295
132MP0005620_abnormal_muscle_contractility0.73618212
133MP0001661_extended_life_span0.73100023
134MP0000427_abnormal_hair_cycle0.72503632
135MP0001784_abnormal_fluid_regulation0.72346907
136MP0005187_abnormal_penis_morphology0.72184776
137MP0003634_abnormal_glial_cell0.71647924
138MP0004858_abnormal_nervous_system0.71566646
139MP0002822_catalepsy0.71036997
140MP0004883_abnormal_blood_vessel0.70651044
141MP0005503_abnormal_tendon_morphology0.70165384
142MP0005387_immune_system_phenotype0.69778703
143MP0001790_abnormal_immune_system0.69778703
144MP0008874_decreased_physiological_sensi0.69719974
145MP0001544_abnormal_cardiovascular_syste0.68619361
146MP0005385_cardiovascular_system_phenoty0.68619361
147MP0000003_abnormal_adipose_tissue0.68168215
148MP0001873_stomach_inflammation0.66896447
149MP0003787_abnormal_imprinting0.66473000
150MP0004085_abnormal_heartbeat0.65630181
151MP0003656_abnormal_erythrocyte_physiolo0.65349460
152MP0005647_abnormal_sex_gland0.65217826
153MP0002419_abnormal_innate_immunity0.62743953

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)3.21848270
2Hypoalphalipoproteinemia (HP:0003233)2.90623124
3Hyporeflexia of lower limbs (HP:0002600)2.86417208
4Epidermoid cyst (HP:0200040)2.85476246
5Xanthomatosis (HP:0000991)2.76068316
6Deep venous thrombosis (HP:0002625)2.74583875
7Intrahepatic cholestasis (HP:0001406)2.73547598
8Myocardial infarction (HP:0001658)2.66437856
9Hyperkalemia (HP:0002153)2.65593724
10Abnormality of the left ventricular outflow tract (HP:0011103)2.62087040
11Subaortic stenosis (HP:0001682)2.62087040
12Complement deficiency (HP:0004431)2.57828737
13Dysmetric saccades (HP:0000641)2.57721622
14Macroorchidism (HP:0000053)2.54857025
15Overgrowth (HP:0001548)2.54298110
16Sudden death (HP:0001699)2.53642023
17Frequent falls (HP:0002359)2.51293118
18Autoimmune thrombocytopenia (HP:0001973)2.45458723
19Ketosis (HP:0001946)2.44859718
20Hyperlipoproteinemia (HP:0010980)2.44100824
21Mitral stenosis (HP:0001718)2.37515929
22Muscle fiber splitting (HP:0003555)2.36857899
23Obstructive sleep apnea (HP:0002870)2.36581389
24Osteolytic defects of the hand bones (HP:0009699)2.36321095
25Osteolytic defects of the phalanges of the hand (HP:0009771)2.36321095
26Lower limb amyotrophy (HP:0007210)2.35145060
27Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.35083363
28Urethral obstruction (HP:0000796)2.34142087
29Difficulty running (HP:0009046)2.33377125
30Right ventricular cardiomyopathy (HP:0011663)2.33299114
31Cerebral aneurysm (HP:0004944)2.32559316
32Type 1 muscle fiber predominance (HP:0003803)2.32136831
33Bundle branch block (HP:0011710)2.30214953
34Distal lower limb amyotrophy (HP:0008944)2.29714338
35Abnormality of glutamine family amino acid metabolism (HP:0010902)2.29573880
36Papillary thyroid carcinoma (HP:0002895)2.24755078
37Broad face (HP:0000283)2.23555262
38Ankyloglossia (HP:0010296)2.23552303
39Narrow palate (HP:0000189)2.23363802
40Vertebral arch anomaly (HP:0008438)2.22509775
41Syncope (HP:0001279)2.21907762
42Gingival bleeding (HP:0000225)2.21793536
43Hematochezia (HP:0002573)2.21733407
44Neonatal hypoglycemia (HP:0001998)2.21431298
45Hypoplastic ischia (HP:0003175)2.20910880
46Hypercholesterolemia (HP:0003124)2.20313795
47Subacute progressive viral hepatitis (HP:0006572)2.19949848
48Blue irides (HP:0000635)2.19680293
49Arterial tortuosity (HP:0005116)2.18573403
50Eczematoid dermatitis (HP:0000976)2.18475182
51Hypolipoproteinemia (HP:0010981)2.17968419
52Periodontitis (HP:0000704)2.16787530
53Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.16660543
54Increased connective tissue (HP:0009025)2.16503150
55Turricephaly (HP:0000262)2.16211287
56Thick nail (HP:0001805)2.15772473
57Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.15138658
58Long toe (HP:0010511)2.13411022
59Ketoacidosis (HP:0001993)2.11862275
60Increased variability in muscle fiber diameter (HP:0003557)2.11037169
61Hypoglycemic coma (HP:0001325)2.10579029
62Exercise-induced myalgia (HP:0003738)2.10180834
63Skin nodule (HP:0200036)2.09444039
64Asymmetric septal hypertrophy (HP:0001670)2.08362920
65Urinary bladder sphincter dysfunction (HP:0002839)2.07541828
66Persistence of primary teeth (HP:0006335)2.07527204
67Heterotopia (HP:0002282)2.07405529
68Abnormality of the ischium (HP:0003174)2.06450011
69Lip pit (HP:0100267)2.05640260
70Pigmentary retinal degeneration (HP:0001146)2.05219673
71Colitis (HP:0002583)2.04127707
72Prolonged QT interval (HP:0001657)2.03980162
73Hypoplasia of the iris (HP:0007676)2.02970582
74Joint hemorrhage (HP:0005261)2.01736352
75EMG: neuropathic changes (HP:0003445)2.01245556
76Aneurysm (HP:0002617)2.00185745
77Vascular tortuosity (HP:0004948)1.99969311
78Germ cell neoplasia (HP:0100728)1.99645186
79Hemiplegia (HP:0002301)1.99469966
80Centrally nucleated skeletal muscle fibers (HP:0003687)1.99427590
81Ventricular tachycardia (HP:0004756)1.98163094
82Abnormality of vision evoked potentials (HP:0000649)1.97228278
83Atrial fibrillation (HP:0005110)1.96560153
84Postural instability (HP:0002172)1.96535787
85Esophageal varix (HP:0002040)1.95251824
86Hydroxyprolinuria (HP:0003080)1.94749941
87Abnormality of proline metabolism (HP:0010907)1.94749941
88Muscle fiber inclusion bodies (HP:0100299)1.93961581
89Truncal obesity (HP:0001956)1.93527334
90Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.93425966
91Abnormality of nail color (HP:0100643)1.92770323
92Drooling (HP:0002307)1.92764865
93Excessive salivation (HP:0003781)1.92764865
94Genetic anticipation (HP:0003743)1.91774327
95Acanthocytosis (HP:0001927)1.90898535
96Conjugated hyperbilirubinemia (HP:0002908)1.89609299
97Gingivitis (HP:0000230)1.88903923
98EMG: myopathic abnormalities (HP:0003458)1.88365092
99Ventricular fibrillation (HP:0001663)1.87966681
100Hyperammonemia (HP:0001987)1.87082689
101Scanning speech (HP:0002168)1.86257955
102Interstitial pulmonary disease (HP:0006530)1.86089154
103Absent frontal sinuses (HP:0002688)1.85709961
104Abnormality of monocarboxylic acid metabolism (HP:0010996)1.85433504
105Abnormality of skeletal muscle fiber size (HP:0012084)1.83994261
106Acute myeloid leukemia (HP:0004808)1.83677163
107Nemaline bodies (HP:0003798)1.83019579
108Prolonged partial thromboplastin time (HP:0003645)1.81708388
109Aortic dissection (HP:0002647)1.81601913
110Cerebral inclusion bodies (HP:0100314)1.81076904
111Laryngomalacia (HP:0001601)1.80365666
112Slow saccadic eye movements (HP:0000514)1.79569474
113Spontaneous hematomas (HP:0007420)1.79438463
114Advanced eruption of teeth (HP:0006288)1.78807972
115Dislocated radial head (HP:0003083)1.78690197
116Action tremor (HP:0002345)1.77487498
117Bowel incontinence (HP:0002607)1.77365370
118Global brain atrophy (HP:0002283)1.76723807
119Abnormality of sulfur amino acid metabolism (HP:0004339)1.76561850
120Mitral valve prolapse (HP:0001634)1.75821836
121Primary atrial arrhythmia (HP:0001692)1.75742002
122Flat acetabular roof (HP:0003180)1.75702117
123Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.75072793
124Abnormality of the distal phalanx of the thumb (HP:0009617)1.74755978
125Hemorrhage of the eye (HP:0011885)1.74435658
126Foot dorsiflexor weakness (HP:0009027)1.74426372
127Onion bulb formation (HP:0003383)1.74229068
128Abnormality of the common coagulation pathway (HP:0010990)1.73977339
129Abnormality of oral frenula (HP:0000190)1.72849809
130Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.72849221
131Facial diplegia (HP:0001349)1.72360209
132Neoplasm of the heart (HP:0100544)1.72334071
133Amyloidosis (HP:0011034)1.72305309
134Distal lower limb muscle weakness (HP:0009053)1.72238391
135Decreased motor nerve conduction velocity (HP:0003431)1.71074683
136Neurofibrillary tangles (HP:0002185)1.71031255
137Hyperglycemia (HP:0003074)1.70788336
138Heart block (HP:0012722)1.70721858
139Increased CSF protein (HP:0002922)1.70685911
140Febrile seizures (HP:0002373)1.69274371
141Abnormality of secondary sexual hair (HP:0009888)1.69265931
142Abnormality of the axillary hair (HP:0100134)1.69265931
143Milia (HP:0001056)1.69256521
144Focal seizures (HP:0007359)1.68832455
145Abnormality of purine metabolism (HP:0004352)1.67989315
146Sandal gap (HP:0001852)1.67725768
147Hyperglycinuria (HP:0003108)1.66128430
148Recurrent gram-negative bacterial infections (HP:0005420)1.65543330
149Ventricular arrhythmia (HP:0004308)1.65040007
150Abnormality of the calf musculature (HP:0001430)1.64682512
151Atrioventricular block (HP:0001678)1.64662839
152Myoglobinuria (HP:0002913)1.63173249
153Broad metatarsal (HP:0001783)1.61624840
154Aortic aneurysm (HP:0004942)1.60939930
155Coarse hair (HP:0002208)1.60502843
156Increased IgE level (HP:0003212)1.60353091
157Impaired social interactions (HP:0000735)1.59578012
158Abnormal social behavior (HP:0012433)1.59578012
159Calf muscle hypertrophy (HP:0008981)1.59453890
160Abnormality of the epiphyses of the hand (HP:0005924)1.59126729
161Hypoglycemic seizures (HP:0002173)1.58823631
162Hypochromic microcytic anemia (HP:0004840)1.58803131
163Generalized hypopigmentation of hair (HP:0011358)1.58438428
164Sensorimotor neuropathy (HP:0007141)1.58411588
165Abnormality of the foot musculature (HP:0001436)1.58146003
166Atrophic scars (HP:0001075)1.58010876
167Reticulocytosis (HP:0001923)1.57132875
168Relative macrocephaly (HP:0004482)1.56686360
169Recurrent bacterial skin infections (HP:0005406)1.55698268
170Mask-like facies (HP:0000298)1.55337151
171Abnormal large intestine physiology (HP:0012700)1.55256243
172Cubitus valgus (HP:0002967)1.55162604
173Abnormality of complement system (HP:0005339)1.54449881
174Status epilepticus (HP:0002133)1.53184996

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CAMK1D3.09947331
2CAMK1G3.03992402
3EEF2K2.66890009
4INSRR2.43624707
5AKT32.28036531
6SIK12.27798213
7TAOK32.17444552
8TTN2.14287779
9JAK12.08039277
10RIPK12.05394286
11PRPF4B1.99335721
12CDK121.95219860
13DAPK21.90709217
14MAP3K131.88493133
15RIPK41.87491896
16LMTK21.86461695
17SIK21.86440637
18SGK31.71718593
19TYK21.71231990
20EPHA31.69995723
21FRK1.68956744
22MAP3K71.67661620
23SGK21.55785383
24MAP3K141.50890785
25LATS11.47138862
26NLK1.41734025
27FGFR41.39227913
28FGFR31.37934722
29PIK3CG1.36234690
30PTK61.33888856
31KSR21.33023498
32MAP3K61.28169680
33PRKAA21.25126216
34BLK1.24757165
35TRIB31.24331833
36IKBKE1.21849695
37STK381.21156969
38DMPK1.18228420
39IRAK31.17193688
40NEK61.14827375
41BRD41.10516232
42MAP3K41.10414517
43PHKG21.10294031
44PHKG11.10294031
45MAP3K101.07059526
46PRKCH1.04656947
47NTRK31.04105458
48FGFR20.99895459
49PRKAA10.99427080
50JAK20.97001564
51SGK4940.95909088
52SGK2230.95909088
53SGK10.95454529
54NEK90.94678221
55PDGFRB0.90701773
56WNK10.90384646
57FER0.89983733
58PKN20.87980727
59PDK10.87506772
60OBSCN0.86903074
61MAP2K40.86437630
62PDPK10.86163802
63MTOR0.82373376
64ZAP700.82283561
65MAP3K90.80545802
66MET0.79044553
67CAMK40.78867207
68JAK30.78756714
69HCK0.78570867
70CDC42BPA0.78546743
71ERN10.76646410
72PKN10.76421365
73MAPK120.76319454
74MARK20.75816867
75MELK0.75704325
76SCYL20.75438208
77MAP3K10.74978654
78PIK3CA0.73887633
79MAP2K30.73683279
80EPHB10.72695058
81RET0.70203584
82ERBB20.70064561
83ICK0.69195895
84TGFBR20.68991604
85MAPKAPK30.68230593
86FES0.67528167
87PDGFRA0.67416284
88BMPR20.66705534
89MAP3K20.65670018
90MAPK70.65572711
91KIT0.65074916
92STK110.63956272
93PAK60.63338640
94CAMKK10.62391741
95MAP4K10.61140743
96CSK0.60929208
97TBK10.59968284
98MAPK110.59877124
99NUAK10.57934163
100CHUK0.56993638
101PRKD10.56420533
102CDK60.55910156
103CAMK10.55391886
104EPHA40.53839647
105NTRK10.53686336
106CDK90.53124020
107RPS6KA20.51020436
108RAF10.50639281
109RPS6KA30.49417963
110ITK0.49288851
111CAMKK20.48820763
112PDK20.48045786
113NTRK20.48039268
114PRKCQ0.47145703
115MAPK100.46795864
116PTK20.46718073
117KSR10.46530659
118FYN0.46040148
119RPS6KB10.46015296
120PAK20.44195732
121IRAK10.44046681
122BTK0.42893510
123MAP3K30.42636855
124BMX0.42382679
125HIPK20.42191470
126EGFR0.41755878
127PAK30.41449346
128CDK50.40096211
129PRKACG0.40008115
130TRPM70.39811177
131CSF1R0.38802679
132MST1R0.37557062
133TAOK10.36853048

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.96252651
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.11143523
3Arginine biosynthesis_Homo sapiens_hsa002201.95092641
4Lysine degradation_Homo sapiens_hsa003101.95007335
5Primary bile acid biosynthesis_Homo sapiens_hsa001201.94548894
6Fatty acid degradation_Homo sapiens_hsa000711.85170804
7Caffeine metabolism_Homo sapiens_hsa002321.83510910
8Type II diabetes mellitus_Homo sapiens_hsa049301.79721602
9PPAR signaling pathway_Homo sapiens_hsa033201.72265216
10ABC transporters_Homo sapiens_hsa020101.61970321
11Bile secretion_Homo sapiens_hsa049761.53665312
12Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.53198605
13Fatty acid metabolism_Homo sapiens_hsa012121.51917632
14Non-small cell lung cancer_Homo sapiens_hsa052231.46718311
15Tryptophan metabolism_Homo sapiens_hsa003801.42164621
16Circadian rhythm_Homo sapiens_hsa047101.36866150
17Acute myeloid leukemia_Homo sapiens_hsa052211.36595355
18Endometrial cancer_Homo sapiens_hsa052131.36445642
19AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.35832344
20Propanoate metabolism_Homo sapiens_hsa006401.33194546
21Renal cell carcinoma_Homo sapiens_hsa052111.32821010
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.32571698
23Adherens junction_Homo sapiens_hsa045201.30860371
24ErbB signaling pathway_Homo sapiens_hsa040121.30802628
25Insulin resistance_Homo sapiens_hsa049311.29491952
26Fatty acid biosynthesis_Homo sapiens_hsa000611.29376842
27Complement and coagulation cascades_Homo sapiens_hsa046101.26199058
28Staphylococcus aureus infection_Homo sapiens_hsa051501.25125107
29Focal adhesion_Homo sapiens_hsa045101.23703868
30VEGF signaling pathway_Homo sapiens_hsa043701.21704028
31Pancreatic cancer_Homo sapiens_hsa052121.19260127
32Phosphatidylinositol signaling system_Homo sapiens_hsa040701.16250006
33Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.15410349
34Adipocytokine signaling pathway_Homo sapiens_hsa049201.14616745
35Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.14108879
36Butanoate metabolism_Homo sapiens_hsa006501.13495927
37Carbohydrate digestion and absorption_Homo sapiens_hsa049731.13028388
38Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.11863492
39Neurotrophin signaling pathway_Homo sapiens_hsa047221.10486847
40Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.09761697
41FoxO signaling pathway_Homo sapiens_hsa040681.05170115
42ECM-receptor interaction_Homo sapiens_hsa045121.04539177
43Starch and sucrose metabolism_Homo sapiens_hsa005001.03312771
44Dorso-ventral axis formation_Homo sapiens_hsa043201.03106325
45Dilated cardiomyopathy_Homo sapiens_hsa054141.01780220
46Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.01399913
47Glycerolipid metabolism_Homo sapiens_hsa005610.95387091
48Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.93926793
49Prostate cancer_Homo sapiens_hsa052150.92984431
50Aldosterone synthesis and secretion_Homo sapiens_hsa049250.87913512
512-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.87738417
52Proteoglycans in cancer_Homo sapiens_hsa052050.87604505
53MicroRNAs in cancer_Homo sapiens_hsa052060.87119555
54Notch signaling pathway_Homo sapiens_hsa043300.85840572
55Leukocyte transendothelial migration_Homo sapiens_hsa046700.85756959
56Salivary secretion_Homo sapiens_hsa049700.83257271
57Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.82670055
58Osteoclast differentiation_Homo sapiens_hsa043800.81963470
59Colorectal cancer_Homo sapiens_hsa052100.81431220
60Thyroid cancer_Homo sapiens_hsa052160.81267349
61Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.81140247
62beta-Alanine metabolism_Homo sapiens_hsa004100.80234375
63Small cell lung cancer_Homo sapiens_hsa052220.79242103
64Insulin signaling pathway_Homo sapiens_hsa049100.78984292
65mTOR signaling pathway_Homo sapiens_hsa041500.77497653
66Sphingolipid signaling pathway_Homo sapiens_hsa040710.76623409
67Fat digestion and absorption_Homo sapiens_hsa049750.76338650
68Renin secretion_Homo sapiens_hsa049240.75591180
69Peroxisome_Homo sapiens_hsa041460.75251882
70Inositol phosphate metabolism_Homo sapiens_hsa005620.75170587
71Jak-STAT signaling pathway_Homo sapiens_hsa046300.75071536
72Insulin secretion_Homo sapiens_hsa049110.73891712
73Glucagon signaling pathway_Homo sapiens_hsa049220.73711397
74Long-term depression_Homo sapiens_hsa047300.73555222
75Gastric acid secretion_Homo sapiens_hsa049710.73138283
76Longevity regulating pathway - mammal_Homo sapiens_hsa042110.73133904
77AMPK signaling pathway_Homo sapiens_hsa041520.71439612
78Thyroid hormone synthesis_Homo sapiens_hsa049180.71052543
79Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.70850221
80B cell receptor signaling pathway_Homo sapiens_hsa046620.70565808
81HIF-1 signaling pathway_Homo sapiens_hsa040660.70432117
82MAPK signaling pathway_Homo sapiens_hsa040100.69718952
83Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.68794876
84Ovarian steroidogenesis_Homo sapiens_hsa049130.68654440
85Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.68099314
86Gap junction_Homo sapiens_hsa045400.67700336
87Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.66931638
88Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.66346976
89Thyroid hormone signaling pathway_Homo sapiens_hsa049190.66266925
90Amphetamine addiction_Homo sapiens_hsa050310.64993170
91Rap1 signaling pathway_Homo sapiens_hsa040150.64831139
92cGMP-PKG signaling pathway_Homo sapiens_hsa040220.64292363
93cAMP signaling pathway_Homo sapiens_hsa040240.63592554
94Circadian entrainment_Homo sapiens_hsa047130.63415928
95Regulation of actin cytoskeleton_Homo sapiens_hsa048100.62812231
96Olfactory transduction_Homo sapiens_hsa047400.61569286
97Morphine addiction_Homo sapiens_hsa050320.61479951
98Calcium signaling pathway_Homo sapiens_hsa040200.61384416
99Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.61011134
100Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.60725548
101Ras signaling pathway_Homo sapiens_hsa040140.58619738
102Toll-like receptor signaling pathway_Homo sapiens_hsa046200.54714781
103Oxytocin signaling pathway_Homo sapiens_hsa049210.53467389
104GnRH signaling pathway_Homo sapiens_hsa049120.53444584
105Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.53358447
106Tight junction_Homo sapiens_hsa045300.53279100
107Glutamatergic synapse_Homo sapiens_hsa047240.53092637
108Central carbon metabolism in cancer_Homo sapiens_hsa052300.52994477
109Cholinergic synapse_Homo sapiens_hsa047250.52740333
110Melanogenesis_Homo sapiens_hsa049160.51869934
111Hepatitis B_Homo sapiens_hsa051610.51597717
112Phospholipase D signaling pathway_Homo sapiens_hsa040720.51234652
113GABAergic synapse_Homo sapiens_hsa047270.50697445
114NF-kappa B signaling pathway_Homo sapiens_hsa040640.49476261
115Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.49281899
116Nicotine addiction_Homo sapiens_hsa050330.47956508
117Toxoplasmosis_Homo sapiens_hsa051450.47381675
118Glioma_Homo sapiens_hsa052140.47240570
119Choline metabolism in cancer_Homo sapiens_hsa052310.46769197
120Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45997920
121Long-term potentiation_Homo sapiens_hsa047200.44781347
122Amoebiasis_Homo sapiens_hsa051460.44427137
123Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.44157857
124Vitamin digestion and absorption_Homo sapiens_hsa049770.44147426
125Hepatitis C_Homo sapiens_hsa051600.44044337
126Glycerophospholipid metabolism_Homo sapiens_hsa005640.43824356
127Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.43581194
128Influenza A_Homo sapiens_hsa051640.42471142
129TNF signaling pathway_Homo sapiens_hsa046680.42245909
130NOD-like receptor signaling pathway_Homo sapiens_hsa046210.41730050
131Platelet activation_Homo sapiens_hsa046110.40738059
132Estrogen signaling pathway_Homo sapiens_hsa049150.40261954
133Pancreatic secretion_Homo sapiens_hsa049720.38081832
134Chronic myeloid leukemia_Homo sapiens_hsa052200.37707509
135Mineral absorption_Homo sapiens_hsa049780.37464354
136Prolactin signaling pathway_Homo sapiens_hsa049170.37267223
137Tuberculosis_Homo sapiens_hsa051520.37245998
138Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.37171094
139Phenylalanine metabolism_Homo sapiens_hsa003600.36989882
140T cell receptor signaling pathway_Homo sapiens_hsa046600.36750285
141Vascular smooth muscle contraction_Homo sapiens_hsa042700.36447691

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