VPS18

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps18 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1polyketide metabolic process (GO:0030638)7.25944053
2doxorubicin metabolic process (GO:0044598)7.25944053
3daunorubicin metabolic process (GO:0044597)7.25944053
4maintenance of protein location in nucleus (GO:0051457)5.22580904
5regulation of mammary gland epithelial cell proliferation (GO:0033599)5.12886525
6protein localization to endosome (GO:0036010)4.75036066
7aminoglycoside antibiotic metabolic process (GO:0030647)4.52193759
8muscle organ morphogenesis (GO:0048644)4.49292455
9histone H4-K5 acetylation (GO:0043981)4.41740575
10histone H4-K8 acetylation (GO:0043982)4.41740575
11regulation of response to osmotic stress (GO:0047484)4.33665534
12histone H4-K12 acetylation (GO:0043983)4.22789098
13negative regulation of telomerase activity (GO:0051974)4.22551634
14heterochromatin organization (GO:0070828)4.14661917
15positive regulation of histone deacetylation (GO:0031065)4.13158412
16protein localization to kinetochore (GO:0034501)4.08446814
17response to dietary excess (GO:0002021)4.04710790
18cytidine deamination (GO:0009972)4.01263589
19cytidine metabolic process (GO:0046087)4.01263589
20cytidine catabolic process (GO:0006216)4.01263589
21synaptic vesicle maturation (GO:0016188)3.99079410
22barbed-end actin filament capping (GO:0051016)3.87127127
23somite rostral/caudal axis specification (GO:0032525)3.85400803
24proline transport (GO:0015824)3.81311713
25positive regulation of protein deacetylation (GO:0090312)3.80451998
26negative regulation of erythrocyte differentiation (GO:0045647)3.73102635
27regulation of telomere maintenance via telomerase (GO:0032210)3.68959927
28amino sugar catabolic process (GO:0046348)3.68754733
29glycosphingolipid catabolic process (GO:0046479)3.66537999
30regulation of MHC class I biosynthetic process (GO:0045343)3.63821982
31mannose metabolic process (GO:0006013)3.62924991
32negative regulation of epidermis development (GO:0045683)3.61091434
33negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.59896539
34maternal placenta development (GO:0001893)3.58997521
35adaptation of signaling pathway (GO:0023058)3.55598665
36positive regulation of macrophage cytokine production (GO:0060907)3.51008180
37stress fiber assembly (GO:0043149)3.50065254
38pre-miRNA processing (GO:0031054)3.46928165
39rRNA transcription (GO:0009303)3.45264807
40negative regulation of interleukin-12 production (GO:0032695)3.44547090
41NIK/NF-kappaB signaling (GO:0038061)3.44477481
42histone H4-K16 acetylation (GO:0043984)3.38848444
43negative regulation of cell cycle G2/M phase transition (GO:1902750)3.38211936
44regulation of translation in response to stress (GO:0043555)3.37673559
45intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)3.37493699
46pinocytosis (GO:0006907)3.36907206
47branching involved in mammary gland duct morphogenesis (GO:0060444)3.36545826
48positive regulation by symbiont of host defense response (GO:0052509)3.36400365
49modulation by symbiont of host defense response (GO:0052031)3.36400365
50modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.36400365
51modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.36400365
52positive regulation by organism of defense response of other organism involved in symbiotic interact3.36400365
53modulation by symbiont of host immune response (GO:0052553)3.36400365
54hormone catabolic process (GO:0042447)3.35689598
55regulation of early endosome to late endosome transport (GO:2000641)3.35297730
56negative regulation of bone resorption (GO:0045779)3.34043801
57negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.33436554
58negative regulation of phagocytosis (GO:0050765)3.31146694
59epithelial cell differentiation involved in prostate gland development (GO:0060742)3.30292985
60lipopolysaccharide-mediated signaling pathway (GO:0031663)3.29629483
61glycolipid catabolic process (GO:0019377)3.26007432
62intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)3.24698191
63detection of temperature stimulus (GO:0016048)3.24542688
64positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.23963036
65chromatin assembly (GO:0031497)3.22904073
66negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.22696099
67primitive streak formation (GO:0090009)3.22038558
68apoptotic cell clearance (GO:0043277)3.21362447
69immunoglobulin mediated immune response (GO:0016064)3.18018644
70COPI coating of Golgi vesicle (GO:0048205)3.14614807
71Golgi transport vesicle coating (GO:0048200)3.14614807
72tachykinin receptor signaling pathway (GO:0007217)3.10158558
73oligosaccharide catabolic process (GO:0009313)3.07184306
74negative regulation of cell size (GO:0045792)3.07041651
75maintenance of protein localization in organelle (GO:0072595)3.06019197
76mitotic sister chromatid segregation (GO:0000070)3.05218210
77interferon-gamma production (GO:0032609)3.04942132
78negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.04940718
79detection of molecule of bacterial origin (GO:0032490)3.03615201
80mitochondrion distribution (GO:0048311)3.02947875
81regulation of leukocyte degranulation (GO:0043300)3.01224151
82negative regulation of toll-like receptor signaling pathway (GO:0034122)3.01036058
83retinoic acid receptor signaling pathway (GO:0048384)2.99099860
84pyrimidine ribonucleoside catabolic process (GO:0046133)2.98902747
85endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.98260437
86nucleoside transmembrane transport (GO:1901642)2.98218230
87RNA stabilization (GO:0043489)2.97714877
88mRNA stabilization (GO:0048255)2.97714877
89positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.97145421
90positive regulation of bone remodeling (GO:0046852)2.94875485
91positive regulation of bone resorption (GO:0045780)2.94875485
92vagina development (GO:0060068)2.94778948
93modulation by symbiont of host cellular process (GO:0044068)2.93633522
94cellular modified amino acid catabolic process (GO:0042219)2.93628287
95regulation of interferon-beta biosynthetic process (GO:0045357)2.91765310
96macrophage activation involved in immune response (GO:0002281)2.88668928
97pentose-phosphate shunt (GO:0006098)2.88088297
98cellular response to thyroid hormone stimulus (GO:0097067)2.85466076
99response to laminar fluid shear stress (GO:0034616)2.85420912
100antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.85272088
101regulation of nuclear cell cycle DNA replication (GO:0033262)2.83228422
102negative regulation of interleukin-6 production (GO:0032715)2.82499935
103phagocytosis, recognition (GO:0006910)2.82252933
104N-acetylneuraminate metabolic process (GO:0006054)2.81532457
105regulation of glucose import in response to insulin stimulus (GO:2001273)2.80768385
106regulation of superoxide anion generation (GO:0032928)2.79704759
107NLS-bearing protein import into nucleus (GO:0006607)2.79686760
108phenol-containing compound catabolic process (GO:0019336)2.78288363
109activation of MAPKKK activity (GO:0000185)2.78156855
110neutrophil activation involved in immune response (GO:0002283)2.76482428
111negative regulation of viral release from host cell (GO:1902187)2.76130286
112positive regulation of Cdc42 GTPase activity (GO:0043089)2.75978196
113myeloid dendritic cell differentiation (GO:0043011)2.74179749
114phosphatidylinositol 3-kinase signaling (GO:0014065)2.73064663
115low-density lipoprotein particle clearance (GO:0034383)2.72242052
116female genitalia development (GO:0030540)2.70469066
117L-alpha-amino acid transmembrane transport (GO:1902475)2.68500765
118negative regulation of peptidyl-serine phosphorylation (GO:0033137)2.67787138
119regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.67374996
120positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.65471072
121establishment of endothelial barrier (GO:0061028)2.64922268
122ceramide catabolic process (GO:0046514)2.64727340
123detection of external biotic stimulus (GO:0098581)2.63683879
124positive regulation of tissue remodeling (GO:0034105)2.62799421
125protein localization to chromosome, centromeric region (GO:0071459)2.62406100
126detection of other organism (GO:0098543)2.62189537
127amyloid precursor protein catabolic process (GO:0042987)2.62065718
128regulation of T-helper 2 cell differentiation (GO:0045628)2.61726454
129regulation of B cell receptor signaling pathway (GO:0050855)2.61524254
130branching involved in labyrinthine layer morphogenesis (GO:0060670)2.61150417
131positive regulation of muscle cell apoptotic process (GO:0010661)2.61038100
132regulation of macrophage cytokine production (GO:0010935)2.60728985
133regulation of cholesterol storage (GO:0010885)2.60663069
134negative regulation of gene silencing (GO:0060969)2.60513808
135negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.58084951
136regulation of mast cell degranulation (GO:0043304)2.57873194
137positive regulation of leukocyte degranulation (GO:0043302)2.57679320
138regulation of myeloid leukocyte mediated immunity (GO:0002886)2.56978450
139hypotonic response (GO:0006971)2.56140940
140response to peptidoglycan (GO:0032494)2.55360936
141germinal center formation (GO:0002467)2.54981778
142response to muramyl dipeptide (GO:0032495)2.54806579
143hyaluronan catabolic process (GO:0030214)2.54748078
144negative regulation of bone remodeling (GO:0046851)2.54424016
145NADPH regeneration (GO:0006740)2.53254676
146regulation of NFAT protein import into nucleus (GO:0051532)2.51913041
147adherens junction assembly (GO:0034333)2.50258192
148response to thyroid hormone (GO:0097066)2.50006366
149sphingolipid catabolic process (GO:0030149)2.46578615
150membrane lipid catabolic process (GO:0046466)2.46125037
151adhesion of symbiont to host (GO:0044406)2.45850150
152cellular response to arsenic-containing substance (GO:0071243)2.45767238
153regulation of vitamin D biosynthetic process (GO:0060556)2.44450823
154apoptotic process involved in morphogenesis (GO:0060561)2.42629914
155positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.42326969
156regulation of type I interferon-mediated signaling pathway (GO:0060338)2.41619662
157detection of bacterium (GO:0016045)2.41610122
158basement membrane organization (GO:0071711)2.40601469
159regulation of regulated secretory pathway (GO:1903305)2.39749519
160regulation of membrane protein ectodomain proteolysis (GO:0051043)2.39619171
161positive regulation of receptor recycling (GO:0001921)2.39508186
162positive regulation of cellular amide metabolic process (GO:0034250)2.39341260
163detection of biotic stimulus (GO:0009595)2.38998335
164adhesion of symbiont to host cell (GO:0044650)2.38512997
165virion attachment to host cell (GO:0019062)2.38512997
166positive regulation of protein dephosphorylation (GO:0035307)2.36794607
167modulation by virus of host process (GO:0019054)2.35041120
168positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.34551319
169positive regulation of cholesterol efflux (GO:0010875)2.34474674
170semaphorin-plexin signaling pathway (GO:0071526)2.34466507
171cortical actin cytoskeleton organization (GO:0030866)2.34071859
172skin morphogenesis (GO:0043589)2.30404422
173glial cell migration (GO:0008347)2.29949389
174regulation of podosome assembly (GO:0071801)2.29538293
175decidualization (GO:0046697)2.29332554
176positive regulation of gamma-delta T cell activation (GO:0046645)2.28305197
177retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.26881257
178vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.26787387
179myeloid dendritic cell activation (GO:0001773)2.26746245
180regulation of defense response to virus by virus (GO:0050690)2.26261846
181response to host immune response (GO:0052572)2.25534841
182response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.25534841

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.92059523
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.28896852
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.28896852
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.28896852
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.76858167
6MYC_22102868_ChIP-Seq_BL_Human2.57047103
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.55957632
8TP63_17297297_ChIP-ChIP_HaCaT_Human2.38959904
9SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.37647197
10RARG_19884340_ChIP-ChIP_MEFs_Mouse2.35220185
11POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.33643675
12* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.31340548
13NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.24892808
14TCF7_22412390_ChIP-Seq_EML_Mouse2.19520121
15SCL_19346495_ChIP-Seq_HPC-7_Human2.04019147
16SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.00262418
17NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.92400011
18ZFP281_18757296_ChIP-ChIP_E14_Mouse1.90269166
19LXR_22292898_ChIP-Seq_THP-1_Human1.89021207
20* VDR_21846776_ChIP-Seq_THP-1_Human1.88754968
21ELK3_25401928_ChIP-Seq_HUVEC_Human1.87316139
22ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.83998117
23* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.82174101
24SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.77352766
25KDM2B_26808549_Chip-Seq_DND41_Human1.77175837
26IRF8_21731497_ChIP-ChIP_J774_Mouse1.76746295
27THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.70214998
28PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.69889304
29NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.69097277
30NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.68809211
31* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.68462857
32TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.68004682
33SPI1_23127762_ChIP-Seq_K562_Human1.67962303
34SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.67151604
35ZFP281_27345836_Chip-Seq_ESCs_Mouse1.67080916
36TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.60864036
37KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.60145869
38* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.59675345
39NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.58542832
40RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.57036784
41KDM2B_26808549_Chip-Seq_K562_Human1.56407518
42NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.51793318
43TCF3_18692474_ChIP-Seq_MEFs_Mouse1.51313254
44PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.50864803
45STAT3_1855785_ChIP-Seq_MESCs_Mouse1.50686388
46IKZF1_21737484_ChIP-ChIP_HCT116_Human1.49728636
47HIF1A_21447827_ChIP-Seq_MCF-7_Human1.47624029
48* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.45780402
49DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.44633634
50CLOCK_20551151_ChIP-Seq_293T_Human1.41616471
51VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.40907771
52TCF3_18692474_ChIP-Seq_MESCs_Mouse1.40428395
53ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.40292010
54MYB_21317192_ChIP-Seq_ERMYB_Mouse1.39795337
55FOXM1_23109430_ChIP-Seq_U2OS_Human1.39666152
56SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.39269597
57* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.35947585
58TP53_22127205_ChIP-Seq_IMR90_Human1.35849061
59NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.34958119
60MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.34856211
61UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.34822317
62IRF8_27001747_Chip-Seq_BMDM_Mouse1.34732407
63RACK7_27058665_Chip-Seq_MCF-7_Human1.34041652
64NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.33635955
65KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.33492965
66NCOR1_26117541_ChIP-Seq_K562_Human1.33109624
67STAT4_19710469_ChIP-ChIP_TH1__Mouse1.31511280
68ZNF263_19887448_ChIP-Seq_K562_Human1.30748866
69PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.30242149
70MAF_26560356_Chip-Seq_TH2_Human1.29539399
71E2F7_22180533_ChIP-Seq_HELA_Human1.29461804
72* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.28673658
73TP63_19390658_ChIP-ChIP_HaCaT_Human1.28669987
74CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.28129186
75BRD4_27068464_Chip-Seq_AML-cells_Mouse1.27758882
76WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.27073655
77RUNX1_22412390_ChIP-Seq_EML_Mouse1.25912379
78TET1_21451524_ChIP-Seq_MESCs_Mouse1.25098019
79MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.24774824
80SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.24401728
81* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.22669707
82SA1_27219007_Chip-Seq_ERYTHROID_Human1.22451971
83GATA1_22383799_ChIP-Seq_G1ME_Mouse1.22442944
84IRF8_22096565_ChIP-ChIP_GC-B_Human1.21360338
85RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18081172
86* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.17888895
87EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.17810784
88Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.16395971
89ATF3_27146783_Chip-Seq_COLON_Human1.15406183
90CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15283174
91SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.15145925
92RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.14816136
93GATA1_19941827_ChIP-Seq_MEL_Mouse1.14293131
94SMC4_20622854_ChIP-Seq_HELA_Human1.14172482
95CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12884719
96PU.1_20513432_ChIP-Seq_Bcells_Mouse1.12771224
97MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.12554522
98TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.11986663
99* BCOR_27268052_Chip-Seq_Bcells_Human1.11979608
100TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.11367954
101SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.10728961
102P300_27058665_Chip-Seq_ZR-75-30cells_Human1.10698505
103MAF_26560356_Chip-Seq_TH1_Human1.09961213
104CDX2_20551321_ChIP-Seq_CACO-2_Human1.09400564
105NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.08674705
106TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08143632
107* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.07603517
108CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.06928041
109KLF4_18555785_ChIP-Seq_MESCs_Mouse1.06655471
110PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05556296
111RARB_27405468_Chip-Seq_BRAIN_Mouse1.04578906
112* P68_20966046_ChIP-Seq_HELA_Human1.04244285
113UBF1/2_26484160_Chip-Seq_HMECs_Human1.04240934
114UTX_26944678_Chip-Seq_JUKART_Human1.04093950
115CTCF_27219007_Chip-Seq_ERYTHROID_Human1.03802430
116STAT6_21828071_ChIP-Seq_BEAS2B_Human1.03081170
117TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.02883880
118POU5F1_16518401_ChIP-PET_MESCs_Mouse1.02730806
119TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.02257567
120FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.01873353
121* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.01233883
122* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.01184744
123KDM2B_26808549_Chip-Seq_JURKAT_Human1.00929578
124SRY_22984422_ChIP-ChIP_TESTIS_Rat1.00820622
125ESR2_21235772_ChIP-Seq_MCF-7_Human1.00543347
126* TFEB_21752829_ChIP-Seq_HELA_Human1.00263722
127E2F1_17053090_ChIP-ChIP_MCF-7_Human0.99814317
128RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.99436865
129OCT4_18692474_ChIP-Seq_MEFs_Mouse0.99158954
130PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.99075674
131* VDR_24763502_ChIP-Seq_THP-1_Human0.98448416
132TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98377309
133GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98246254
134* ELF1_20517297_ChIP-Seq_JURKAT_Human0.97007115
135SPI1_23547873_ChIP-Seq_NB4_Human0.96888889
136POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.96883886
137* FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.93989372
138EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.92575490
139ERG_21242973_ChIP-ChIP_JURKAT_Human0.90393326
140STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.90182387

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004858_abnormal_nervous_system4.32084702
2MP0003172_abnormal_lysosome_physiology3.92840586
3MP0002254_reproductive_system_inflammat3.58526896
4MP0005451_abnormal_body_composition3.42268518
5MP0003183_abnormal_peptide_metabolism3.20932374
6MP0005257_abnormal_intraocular_pressure3.12617200
7MP0003011_delayed_dark_adaptation2.97385374
8MP0004264_abnormal_extraembryonic_tissu2.90657433
9MP0005058_abnormal_lysosome_morphology2.81541130
10MP0001849_ear_inflammation2.73082482
11MP0003705_abnormal_hypodermis_morpholog2.65263188
12MP0006082_CNS_inflammation2.64149741
13MP0008961_abnormal_basal_metabolism2.55218236
14MP0008260_abnormal_autophagy2.49031388
15MP0005075_abnormal_melanosome_morpholog2.47186383
16MP0002332_abnormal_exercise_endurance2.27080158
17MP0003303_peritoneal_inflammation2.26992119
18MP0008438_abnormal_cutaneous_collagen2.25974410
19MP0002877_abnormal_melanocyte_morpholog2.12579107
20MP0010352_gastrointestinal_tract_polyps2.09788776
21MP0005499_abnormal_olfactory_system2.03557594
22MP0005394_taste/olfaction_phenotype2.03557594
23MP0004510_myositis2.00745261
24MP0003122_maternal_imprinting2.00537694
25MP0009840_abnormal_foam_cell1.98426261
26MP0006292_abnormal_olfactory_placode1.79169613
27MP0000569_abnormal_digit_pigmentation1.75968443
28MP0002148_abnormal_hypersensitivity_rea1.75306039
29MP0003453_abnormal_keratinocyte_physiol1.73276658
30MP0003890_abnormal_embryonic-extraembry1.70132837
31MP0004859_abnormal_synaptic_plasticity1.68085173
32MP0002998_abnormal_bone_remodeling1.67421433
33MP0003279_aneurysm1.66267334
34MP0008057_abnormal_DNA_replication1.62535063
35MP0001533_abnormal_skeleton_physiology1.57620938
36MP0002653_abnormal_ependyma_morphology1.56562456
37MP0004233_abnormal_muscle_weight1.49444776
38MP0003436_decreased_susceptibility_to1.48900596
39MP0001348_abnormal_lacrimal_gland1.48107485
40MP0009785_altered_susceptibility_to1.47401365
41MP0003075_altered_response_to1.46687213
42MP0003724_increased_susceptibility_to1.45178270
43MP0001835_abnormal_antigen_presentation1.42692473
44MP0004272_abnormal_basement_membrane1.39575405
45MP0002396_abnormal_hematopoietic_system1.35878394
46MP0002909_abnormal_adrenal_gland1.35804824
47MP0003191_abnormal_cellular_cholesterol1.31523715
48MP0003828_pulmonary_edema1.30688023
49MP0003566_abnormal_cell_adhesion1.29695120
50MP0000678_abnormal_parathyroid_gland1.24080527
51MP0000604_amyloidosis1.19555624
52MP0003448_altered_tumor_morphology1.18664237
53MP0003938_abnormal_ear_development1.17433352
54MP0009333_abnormal_splenocyte_physiolog1.13174559
55MP0005310_abnormal_salivary_gland1.12584557
56MP0004185_abnormal_adipocyte_glucose1.09171425
57MP0000767_abnormal_smooth_muscle1.08457839
58MP0001958_emphysema1.07734913
59MP0009278_abnormal_bone_marrow1.07526667
60MP0006035_abnormal_mitochondrial_morpho1.07407899
61MP0005000_abnormal_immune_tolerance1.07310573
62MP0003300_gastrointestinal_ulcer1.06004535
63MP0002452_abnormal_antigen_presenting1.04292197
64MP0001915_intracranial_hemorrhage1.04164455
65MP0001800_abnormal_humoral_immune1.04008464
66MP0001845_abnormal_inflammatory_respons1.03870900
67MP0003121_genomic_imprinting1.03139259
68MP0002277_abnormal_respiratory_mucosa1.02986315
69MP0003283_abnormal_digestive_organ0.99908849
70MP0000858_altered_metastatic_potential0.99493579
71MP0000689_abnormal_spleen_morphology0.97467958
72MP0002088_abnormal_embryonic_growth/wei0.97254310
73MP0006054_spinal_hemorrhage0.97152970
74MP0002090_abnormal_vision0.95785222
75MP0000015_abnormal_ear_pigmentation0.95683152
76MP0009764_decreased_sensitivity_to0.95434025
77MP0003984_embryonic_growth_retardation0.94977914
78MP0005387_immune_system_phenotype0.94724950
79MP0001790_abnormal_immune_system0.94724950
80MP0010307_abnormal_tumor_latency0.94554257
81MP0004808_abnormal_hematopoietic_stem0.94088907
82MP0008469_abnormal_protein_level0.93951647
83MP0001853_heart_inflammation0.93936631
84MP0005671_abnormal_response_to0.93899760
85MP0004947_skin_inflammation0.93396781
86MP0005166_decreased_susceptibility_to0.93265169
87MP0008770_decreased_survivor_rate0.92935767
88MP0001672_abnormal_embryogenesis/_devel0.92414316
89MP0005380_embryogenesis_phenotype0.92414316
90MP0005390_skeleton_phenotype0.91626685
91MP0005167_abnormal_blood-brain_barrier0.91541529
92MP0005409_darkened_coat_color0.91198864
93MP0003091_abnormal_cell_migration0.90646952
94MP0005623_abnormal_meninges_morphology0.89835874
95MP0004957_abnormal_blastocyst_morpholog0.89514077
96MP0001545_abnormal_hematopoietic_system0.89289210
97MP0005397_hematopoietic_system_phenotyp0.89289210
98MP0005165_increased_susceptibility_to0.88035354
99MP0005023_abnormal_wound_healing0.87664459
100MP0002419_abnormal_innate_immunity0.87612423
101MP0002970_abnormal_white_adipose0.87485341
102MP0000350_abnormal_cell_proliferation0.87106184
103MP0002092_abnormal_eye_morphology0.86803741
104MP0000465_gastrointestinal_hemorrhage0.86730493
105MP0001819_abnormal_immune_cell0.86630444
106MP0010155_abnormal_intestine_physiology0.86143470
107MP0002420_abnormal_adaptive_immunity0.85748608
108MP0003690_abnormal_glial_cell0.85482813
109MP0002269_muscular_atrophy0.85252022
110MP0002722_abnormal_immune_system0.85190641
111MP0009046_muscle_twitch0.84925532
112MP0005464_abnormal_platelet_physiology0.84250281
113MP0003221_abnormal_cardiomyocyte_apopto0.83762400
114MP0005266_abnormal_metabolism0.82911954
115MP0000490_abnormal_crypts_of0.82033466
116MP0005076_abnormal_cell_differentiation0.81977909
117MP0002723_abnormal_immune_serum0.81895263
118MP0002405_respiratory_system_inflammati0.81852372
119MP0005025_abnormal_response_to0.81688205
120MP0000747_muscle_weakness0.81296808
121MP0003795_abnormal_bone_structure0.81193362
122MP0000920_abnormal_myelination0.79586184
123MP0003634_abnormal_glial_cell0.79350534
124MP0002086_abnormal_extraembryonic_tissu0.78428224
125MP0002398_abnormal_bone_marrow0.77736810
126MP0000371_diluted_coat_color0.77444388
127MP0000343_altered_response_to0.77386905
128MP0000716_abnormal_immune_system0.76521608
129MP0000358_abnormal_cell_content/0.76444690
130MP0000750_abnormal_muscle_regeneration0.76311056
131MP0001542_abnormal_bone_strength0.76182153
132MP0003329_amyloid_beta_deposits0.75943462
133MP0010234_abnormal_vibrissa_follicle0.75337982
134MP0002429_abnormal_blood_cell0.75244858
135MP0003123_paternal_imprinting0.75167356
136MP0002089_abnormal_postnatal_growth/wei0.72460057
137MP0002060_abnormal_skin_morphology0.72230041
138MP0004381_abnormal_hair_follicle0.72106942
139MP0005164_abnormal_response_to0.71871633
140MP0005384_cellular_phenotype0.71760797
141MP0000685_abnormal_immune_system0.71411607
142MP0000313_abnormal_cell_death0.69768130
143MP0003045_fibrosis0.69556230
144MP0005621_abnormal_cell_physiology0.68895788

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of liposaccharide metabolism (HP:0010968)4.89312910
2Abnormality of glycosphingolipid metabolism (HP:0004343)4.89312910
3Abnormality of glycolipid metabolism (HP:0010969)4.89312910
4Abnormality of the lower motor neuron (HP:0002366)4.81076967
5Bilateral microphthalmos (HP:0007633)4.79218588
6Hepatoblastoma (HP:0002884)3.76761984
7Multiple enchondromatosis (HP:0005701)3.63566115
8Increased cerebral lipofuscin (HP:0011813)3.53884243
9Abnormality of macrophages (HP:0004311)3.53646833
10Vertebral compression fractures (HP:0002953)3.34672155
11Amyotrophic lateral sclerosis (HP:0007354)3.28269348
12Hypochromic microcytic anemia (HP:0004840)3.24711090
13Hand muscle atrophy (HP:0009130)3.18608508
14Ependymoma (HP:0002888)3.16326879
15Achilles tendon contracture (HP:0001771)3.13925209
16Distal upper limb amyotrophy (HP:0007149)3.02880554
17Upper limb amyotrophy (HP:0009129)3.02880554
18Neurofibrillary tangles (HP:0002185)2.96153985
19Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.90955292
20Apathy (HP:0000741)2.88544004
21Premature rupture of membranes (HP:0001788)2.86554457
22Upper motor neuron abnormality (HP:0002127)2.86429962
23Hyperacusis (HP:0010780)2.82924242
24Abnormality of the Achilles tendon (HP:0005109)2.81042679
25Testicular atrophy (HP:0000029)2.74202339
26Diminished motivation (HP:0000745)2.73396156
27Increased neuronal autofluorescent lipopigment (HP:0002074)2.70390169
28Rib fusion (HP:0000902)2.68914716
29Cerebral inclusion bodies (HP:0100314)2.68765613
30Resting tremor (HP:0002322)2.61666197
31Astrocytoma (HP:0009592)2.61244444
32Abnormality of the astrocytes (HP:0100707)2.61244444
33Nuclear cataract (HP:0100018)2.56618612
34Systemic lupus erythematosus (HP:0002725)2.55070379
35Protrusio acetabuli (HP:0003179)2.54572434
36Generalized hypotonia (HP:0001290)2.54312619
37Neoplasm of striated muscle (HP:0009728)2.53729747
38Neuronal loss in central nervous system (HP:0002529)2.53720647
39Peritonitis (HP:0002586)2.52365888
40Dysostosis multiplex (HP:0000943)2.50120545
41Horizontal nystagmus (HP:0000666)2.49859915
42Difficulty running (HP:0009046)2.49184803
43Spastic tetraparesis (HP:0001285)2.37867161
44Elevated erythrocyte sedimentation rate (HP:0003565)2.37772414
45Spinal muscular atrophy (HP:0007269)2.34861123
46Myocardial infarction (HP:0001658)2.32886700
47Recurrent abscess formation (HP:0002722)2.32813257
48Ragged-red muscle fibers (HP:0003200)2.32778259
49Recurrent gram-negative bacterial infections (HP:0005420)2.31370135
50Nasal polyposis (HP:0100582)2.31221234
51Distal lower limb amyotrophy (HP:0008944)2.30503530
52Preauricular skin tag (HP:0000384)2.30423392
53Distal lower limb muscle weakness (HP:0009053)2.27618751
54Fused cervical vertebrae (HP:0002949)2.26890016
55Fasciculations (HP:0002380)2.26719510
56Vaginal fistula (HP:0004320)2.25611903
57Interstitial pulmonary disease (HP:0006530)2.25220597
58Abnormal neuron morphology (HP:0012757)2.23769020
59Abnormality of the motor neurons (HP:0002450)2.23769020
60Macroorchidism (HP:0000053)2.21409816
61Cervical subluxation (HP:0003308)2.21370157
62Rhabdomyosarcoma (HP:0002859)2.20838302
63Increased connective tissue (HP:0009025)2.20423602
64Intestinal fistula (HP:0100819)2.19386014
65Supranuclear gaze palsy (HP:0000605)2.19235211
66Centrally nucleated skeletal muscle fibers (HP:0003687)2.17944683
67Neoplasm of the heart (HP:0100544)2.17345715
68Abnormality of the musculature of the hand (HP:0001421)2.17104298
69Thoracic kyphosis (HP:0002942)2.16118240
70J-shaped sella turcica (HP:0002680)2.15966025
71Cerebral aneurysm (HP:0004944)2.14112028
72Large earlobe (HP:0009748)2.13277579
73Disinhibition (HP:0000734)2.12607563
74Recurrent bacterial skin infections (HP:0005406)2.11645875
75Rectovaginal fistula (HP:0000143)2.11468335
76Rectal fistula (HP:0100590)2.11468335
77Cellulitis (HP:0100658)2.10318896
78Spinal rigidity (HP:0003306)2.09745506
79Mediastinal lymphadenopathy (HP:0100721)2.09572147
80Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.09164782
81Skin tags (HP:0010609)2.07628063
82Ocular albinism (HP:0001107)2.06723264
83Tetraplegia (HP:0002445)2.05773241
84Absent frontal sinuses (HP:0002688)2.04987312
85Abnormality of the salivary glands (HP:0010286)2.04770216
86Asymmetric septal hypertrophy (HP:0001670)2.03765912
87Short humerus (HP:0005792)2.03001798
88Amyloidosis (HP:0011034)2.02722739
89Hypoplasia of the fovea (HP:0007750)2.02253397
90Aplasia/Hypoplasia of the fovea (HP:0008060)2.02253397
91Vacuolated lymphocytes (HP:0001922)2.00729431
92Purpura (HP:0000979)1.99442162
93Eczematoid dermatitis (HP:0000976)1.99013727
94Periauricular skin pits (HP:0100277)1.98962833
95Preauricular pit (HP:0004467)1.98962833
96Axonal loss (HP:0003447)1.98685554
97Genu recurvatum (HP:0002816)1.98574040
98Tongue fasciculations (HP:0001308)1.97483720
99Aplasia/hypoplasia of the humerus (HP:0006507)1.97381387
100EMG: neuropathic changes (HP:0003445)1.96244840
101Skin nodule (HP:0200036)1.96097714
102Increased variability in muscle fiber diameter (HP:0003557)1.95766806
103Thin bony cortex (HP:0002753)1.95766636
104Progressive neurologic deterioration (HP:0002344)1.95324937
105Abnormality of the nasal mucosa (HP:0000433)1.95019184
106Abnormality of the thoracic spine (HP:0100711)1.94730378
107Spontaneous hematomas (HP:0007420)1.94228052
108Increased CSF protein (HP:0002922)1.93311520
109Insomnia (HP:0100785)1.92798355
110Atrophy/Degeneration involving motor neurons (HP:0007373)1.92740700
111Mutism (HP:0002300)1.92545200
112Pathologic fracture (HP:0002756)1.91616765
113Bone pain (HP:0002653)1.89927090
114Abnormal cartilage morphology (HP:0002763)1.89347846
115Obstructive lung disease (HP:0006536)1.89128231
116Chronic obstructive pulmonary disease (HP:0006510)1.89128231
117Progressive muscle weakness (HP:0003323)1.87757093
118Short nail (HP:0001799)1.87271132
119Prolonged neonatal jaundice (HP:0006579)1.86101274
120Difficulty climbing stairs (HP:0003551)1.85829659
121Gingivitis (HP:0000230)1.85699477
122Muscle fibrillation (HP:0010546)1.85069955
123Hepatosplenomegaly (HP:0001433)1.84774869
124Amblyopia (HP:0000646)1.84120909
125Urinary glycosaminoglycan excretion (HP:0003541)1.83120925
126Mucopolysacchariduria (HP:0008155)1.83120925
127Personality changes (HP:0000751)1.83025490
128Abnormality of skeletal muscle fiber size (HP:0012084)1.82577213
129Renal duplication (HP:0000075)1.81944437
130Supernumerary nipples (HP:0002558)1.81510860
131Gastrointestinal stroma tumor (HP:0100723)1.80909650
132Long palpebral fissure (HP:0000637)1.79919354
133Loss of speech (HP:0002371)1.79411766
134Ulnar bowing (HP:0003031)1.78605709
135Hemiparesis (HP:0001269)1.77988320
136Emphysema (HP:0002097)1.77771400
137Blue sclerae (HP:0000592)1.77497408
138Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.77406135
139Abnormality of polysaccharide metabolism (HP:0011012)1.75569298
140Abnormality of glycosaminoglycan metabolism (HP:0004371)1.75569298
141Abnormality of mucopolysaccharide metabolism (HP:0011020)1.75569298
142Orchitis (HP:0100796)1.75414163
143Hypopigmentation of the fundus (HP:0007894)1.75241800
144Increased serum ferritin (HP:0003281)1.75163366
145Pseudobulbar signs (HP:0002200)1.75061864
146Tetraparesis (HP:0002273)1.74450922
147Petechiae (HP:0000967)1.74158175
148Rapidly progressive (HP:0003678)1.73155911
149Cardiomegaly (HP:0001640)1.72625558
150Myositis (HP:0100614)1.72417258
151Iris hypopigmentation (HP:0007730)1.72257103
152Polygenic inheritance (HP:0010982)1.72152025
153Joint stiffness (HP:0001387)1.68847423
154Ankle contracture (HP:0006466)1.68593555
155Osteolytic defects of the phalanges of the hand (HP:0009771)1.68035028
156Osteolytic defects of the hand bones (HP:0009699)1.68035028
157Dilatation of the ascending aorta (HP:0005111)1.65710903
158Generalized amyotrophy (HP:0003700)1.65089461
159Dementia (HP:0000726)1.64986265
160Disproportionate tall stature (HP:0001519)1.63807671
161Broad face (HP:0000283)1.63087839
162Shallow orbits (HP:0000586)1.62828403
163Spondylolisthesis (HP:0003302)1.61842535
164Abnormality of the vasculature of the conjunctiva (HP:0008054)1.59879378
165Natal tooth (HP:0000695)1.58975366

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK126.37430509
2ERN14.99672985
3GRK54.02114255
4GRK63.78093419
5IRAK33.34274442
6CSF1R3.27619767
7NME23.17507886
8SMG12.80105233
9TGFBR22.76317420
10TYRO32.54156709
11MATK2.42113205
12NTRK12.22886138
13MAP3K112.17250794
14TRIB32.16017974
15MAP3K92.07524059
16MAP3K32.03730443
17STK102.01904462
18MAP3K101.89487593
19MOS1.81225150
20GRK11.78656467
21PAK41.74684787
22ADRBK21.69512080
23MAPK71.63243666
24GRK71.57041432
25PIM21.53502588
26WNK11.52934120
27RIPK41.49437563
28TESK11.43345843
29SCYL21.43178928
30ALK1.33916643
31IRAK41.32579568
32CAMK41.31765257
33MAP3K11.27132700
34SIK21.27043119
35ARAF1.25494082
36MARK21.25298417
37CDC42BPA1.24181170
38MAP3K141.23409164
39PRKG21.14290238
40HIPK21.11075776
41SIK31.10455410
42BMX1.08943135
43RIPK11.04972033
44KIT1.02015922
45PKN21.01876155
46MAP2K41.01481181
47MAP3K130.99746065
48TTK0.98902718
49IRAK20.97511319
50FGFR40.91638601
51PTK20.90420842
52ZAP700.90258511
53CSK0.88878807
54PAK60.87331448
55RPS6KA20.85793489
56LIMK10.81081808
57PDPK10.80945560
58ABL20.80369869
59MAP4K10.80027287
60EEF2K0.79285552
61FES0.77497334
62MAP3K60.76652706
63KSR20.76118198
64IKBKB0.74739594
65DYRK1B0.74157285
66JAK30.71372369
67ICK0.70095854
68HCK0.67986132
69TBK10.67572334
70BLK0.66992485
71MAPK120.66124974
72CAMKK10.64469286
73EPHB20.64298058
74EPHA20.63863472
75RPS6KL10.63218548
76RPS6KC10.63218548
77MTOR0.63102666
78KDR0.62671097
79PDGFRA0.62416437
80BRAF0.62271744
81ADRBK10.61789365
82AKT20.61732809
83TAOK20.61637204
84CDK70.58695585
85LMTK20.58178990
86TAOK10.56988126
87TTN0.56821078
88PTK60.56086505
89NEK90.54773384
90EPHB10.53608946
91LATS20.52961332
92FGFR30.51559321
93CDK60.50978644
94MAP2K60.49798108
95CHUK0.49653520
96TYK20.47206000
97PDK10.47149301
98SYK0.46947730
99MAP3K70.46809021
100MAP3K50.45127324
101DAPK20.45118852
102BTK0.45061501
103LRRK20.44264276
104PRKD30.43715115
105JAK20.43593093
106SIK10.43500035
107MARK30.41041356
108PAK20.40710997
109DAPK10.40571597
110DDR20.39173816
111PRKCD0.38656625
112PRKCH0.38477360
113IKBKE0.38386833
114JAK10.37985379
115RPS6KA60.37796098
116MAPK110.37549873
117NTRK30.36770906
118MAPK100.36567297
119MAP2K30.36476785
120MAP3K80.36039872
121ITK0.35891341
122PRPF4B0.35733132
123CAMK1D0.35530094
124DAPK30.34062221
125FGR0.33804276
126EGFR0.32662992
127PAK10.30774776
128CDK150.30305929
129MAPK40.29833139
130FLT30.27983598
131CDK50.27077117
132PAK30.26634966
133SRC0.26602611
134IGF1R0.26167094
135CHEK20.25794257
136CAMK1G0.25489929
137STK380.25070042
138INSR0.24909221
139CDK20.24871604
140TESK20.24605990
141PRKD20.24175294

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006034.76291916
2Vitamin B6 metabolism_Homo sapiens_hsa007502.88321563
3Glycosaminoglycan degradation_Homo sapiens_hsa005312.87483194
4Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.76122825
5Other glycan degradation_Homo sapiens_hsa005112.43143679
6Fructose and mannose metabolism_Homo sapiens_hsa000512.33858921
7Lysosome_Homo sapiens_hsa041422.22971057
8Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.90650782
9Galactose metabolism_Homo sapiens_hsa000521.85447113
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.76684187
11mTOR signaling pathway_Homo sapiens_hsa041501.71948751
12Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.70287249
13B cell receptor signaling pathway_Homo sapiens_hsa046621.61675296
14Leishmaniasis_Homo sapiens_hsa051401.45429484
15Phospholipase D signaling pathway_Homo sapiens_hsa040721.41641096
16TNF signaling pathway_Homo sapiens_hsa046681.40806796
17Synaptic vesicle cycle_Homo sapiens_hsa047211.39724577
18Malaria_Homo sapiens_hsa051441.32168518
19Vibrio cholerae infection_Homo sapiens_hsa051101.30067465
20Neurotrophin signaling pathway_Homo sapiens_hsa047221.29229447
21Tuberculosis_Homo sapiens_hsa051521.25932919
22Non-small cell lung cancer_Homo sapiens_hsa052231.25224764
23Acute myeloid leukemia_Homo sapiens_hsa052211.21908481
24Osteoclast differentiation_Homo sapiens_hsa043801.21490491
25VEGF signaling pathway_Homo sapiens_hsa043701.19260259
26Rheumatoid arthritis_Homo sapiens_hsa053231.18205996
27Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.15293396
28Hepatitis B_Homo sapiens_hsa051611.13053894
29Central carbon metabolism in cancer_Homo sapiens_hsa052301.11036444
30Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.10099114
31Regulation of actin cytoskeleton_Homo sapiens_hsa048101.09998985
32Amoebiasis_Homo sapiens_hsa051461.09366235
33Hepatitis C_Homo sapiens_hsa051601.05807796
34Phosphatidylinositol signaling system_Homo sapiens_hsa040701.05234122
35Inositol phosphate metabolism_Homo sapiens_hsa005621.05044287
36Viral myocarditis_Homo sapiens_hsa054161.01702577
37Apoptosis_Homo sapiens_hsa042101.00635063
38Glioma_Homo sapiens_hsa052140.98194646
39Thyroid cancer_Homo sapiens_hsa052160.97889807
40Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.95986462
41Chronic myeloid leukemia_Homo sapiens_hsa052200.93595338
42Proteoglycans in cancer_Homo sapiens_hsa052050.90882828
43Endocytosis_Homo sapiens_hsa041440.90236810
44Thyroid hormone signaling pathway_Homo sapiens_hsa049190.88620434
45Leukocyte transendothelial migration_Homo sapiens_hsa046700.88559748
46Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.88318647
47GnRH signaling pathway_Homo sapiens_hsa049120.85828756
48NOD-like receptor signaling pathway_Homo sapiens_hsa046210.85695168
49Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.85679481
50Viral carcinogenesis_Homo sapiens_hsa052030.85645050
51Choline metabolism in cancer_Homo sapiens_hsa052310.84429215
52Sphingolipid metabolism_Homo sapiens_hsa006000.83640093
53Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.82950210
54Focal adhesion_Homo sapiens_hsa045100.82020727
55Toll-like receptor signaling pathway_Homo sapiens_hsa046200.81347244
56Platelet activation_Homo sapiens_hsa046110.80579886
57Collecting duct acid secretion_Homo sapiens_hsa049660.80323586
58Rap1 signaling pathway_Homo sapiens_hsa040150.79350249
59Sphingolipid signaling pathway_Homo sapiens_hsa040710.78596284
60Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.77570652
61Pentose and glucuronate interconversions_Homo sapiens_hsa000400.76546335
62Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.75468246
63Herpes simplex infection_Homo sapiens_hsa051680.73523499
64Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.73268198
65Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.71708755
66Pancreatic cancer_Homo sapiens_hsa052120.71512012
67Pertussis_Homo sapiens_hsa051330.71402052
68Phagosome_Homo sapiens_hsa041450.71396327
69Epstein-Barr virus infection_Homo sapiens_hsa051690.71081433
70Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.70196534
71Small cell lung cancer_Homo sapiens_hsa052220.69233282
72Transcriptional misregulation in cancer_Homo sapiens_hsa052020.69146326
73RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.69006507
74Long-term potentiation_Homo sapiens_hsa047200.68805607
75Measles_Homo sapiens_hsa051620.68766357
76Type II diabetes mellitus_Homo sapiens_hsa049300.67482425
77Chemokine signaling pathway_Homo sapiens_hsa040620.65797350
78Bladder cancer_Homo sapiens_hsa052190.65571430
79Allograft rejection_Homo sapiens_hsa053300.65451256
80Systemic lupus erythematosus_Homo sapiens_hsa053220.65314019
81HTLV-I infection_Homo sapiens_hsa051660.65165957
82Toxoplasmosis_Homo sapiens_hsa051450.64347153
83Antigen processing and presentation_Homo sapiens_hsa046120.64321594
84Oxytocin signaling pathway_Homo sapiens_hsa049210.64062130
85Long-term depression_Homo sapiens_hsa047300.63825224
86Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.63630024
87Insulin signaling pathway_Homo sapiens_hsa049100.63367211
88MicroRNAs in cancer_Homo sapiens_hsa052060.63250448
89Salivary secretion_Homo sapiens_hsa049700.62171102
90Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.62083002
91Longevity regulating pathway - mammal_Homo sapiens_hsa042110.61164516
92GABAergic synapse_Homo sapiens_hsa047270.60988563
93Adipocytokine signaling pathway_Homo sapiens_hsa049200.60942414
94Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58409541
95Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58263999
96Hematopoietic cell lineage_Homo sapiens_hsa046400.58234796
97Endometrial cancer_Homo sapiens_hsa052130.57797104
98Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.56829832
99Estrogen signaling pathway_Homo sapiens_hsa049150.56413871
100Glutamatergic synapse_Homo sapiens_hsa047240.56283761
101African trypanosomiasis_Homo sapiens_hsa051430.56013812
102Renal cell carcinoma_Homo sapiens_hsa052110.55821557
103Staphylococcus aureus infection_Homo sapiens_hsa051500.55770011
104MAPK signaling pathway_Homo sapiens_hsa040100.55562431
105HIF-1 signaling pathway_Homo sapiens_hsa040660.53556779
106Gap junction_Homo sapiens_hsa045400.53056155
107Influenza A_Homo sapiens_hsa051640.52780039
108Prion diseases_Homo sapiens_hsa050200.51685029
109Notch signaling pathway_Homo sapiens_hsa043300.50853614
110Legionellosis_Homo sapiens_hsa051340.50801722
111Dorso-ventral axis formation_Homo sapiens_hsa043200.50236213
112NF-kappa B signaling pathway_Homo sapiens_hsa040640.49915983
113Colorectal cancer_Homo sapiens_hsa052100.49761205
114Graft-versus-host disease_Homo sapiens_hsa053320.49713989
115Pentose phosphate pathway_Homo sapiens_hsa000300.49594027
116Insulin resistance_Homo sapiens_hsa049310.49319832
117Salmonella infection_Homo sapiens_hsa051320.48649772
118ErbB signaling pathway_Homo sapiens_hsa040120.48352719
119Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.48319479
120AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.47602549
121Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.47414711
122Prostate cancer_Homo sapiens_hsa052150.47390195
123T cell receptor signaling pathway_Homo sapiens_hsa046600.46287939
124Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.44526547
125Prolactin signaling pathway_Homo sapiens_hsa049170.44338850
126cAMP signaling pathway_Homo sapiens_hsa040240.44118564
127Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.43105785
128Shigellosis_Homo sapiens_hsa051310.42650239

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