VPS26A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)6.86264313
2piRNA metabolic process (GO:0034587)5.95247661
3fusion of sperm to egg plasma membrane (GO:0007342)5.51904251
4sperm-egg recognition (GO:0035036)5.41467634
5acrosome assembly (GO:0001675)5.36395183
6multicellular organism reproduction (GO:0032504)5.17396855
7binding of sperm to zona pellucida (GO:0007339)5.15353287
8cilium or flagellum-dependent cell motility (GO:0001539)5.08185557
9male meiosis (GO:0007140)4.90356843
10cell-cell recognition (GO:0009988)4.83961441
11synaptonemal complex assembly (GO:0007130)4.82485190
12synaptonemal complex organization (GO:0070193)4.64734971
13negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.60281716
14cell wall macromolecule metabolic process (GO:0044036)4.57383819
15cell wall macromolecule catabolic process (GO:0016998)4.57383819
16cullin deneddylation (GO:0010388)4.52575786
17regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.51948221
18ribosome assembly (GO:0042255)4.50216976
19positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.43640601
20establishment of integrated proviral latency (GO:0075713)4.39700083
21anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.34862113
22negative regulation of ligase activity (GO:0051352)4.24482734
23negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.24482734
24protein deneddylation (GO:0000338)4.22393050
25DNA double-strand break processing (GO:0000729)4.21885072
26sperm motility (GO:0030317)4.21279246
27reproduction (GO:0000003)4.16727131
28regulation of cellular amino acid metabolic process (GO:0006521)3.98192421
29plasma membrane fusion (GO:0045026)3.93146385
30nuclear pore complex assembly (GO:0051292)3.91229120
31chromosome organization involved in meiosis (GO:0070192)3.86474002
32positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.84082377
33DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.79997479
34DNA ligation (GO:0006266)3.76237584
35protein K6-linked ubiquitination (GO:0085020)3.76162262
36signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.75832888
37signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.75832888
38signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.75832888
39male meiosis I (GO:0007141)3.75445125
40intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.74592578
41signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.74592578
42establishment of viral latency (GO:0019043)3.72702661
43nuclear pore organization (GO:0006999)3.72382674
44positive regulation of ligase activity (GO:0051351)3.70195236
45monoubiquitinated protein deubiquitination (GO:0035520)3.69304472
46meiotic nuclear division (GO:0007126)3.69136898
47signal transduction involved in DNA integrity checkpoint (GO:0072401)3.62870518
48signal transduction involved in DNA damage checkpoint (GO:0072422)3.62870518
49spermatid development (GO:0007286)3.61944066
50signal transduction involved in cell cycle checkpoint (GO:0072395)3.60449338
51regulation of ubiquitin-protein transferase activity (GO:0051438)3.56210640
52mitotic metaphase plate congression (GO:0007080)3.56047705
53attachment of spindle microtubules to kinetochore (GO:0008608)3.50930013
54protein localization to chromosome, centromeric region (GO:0071459)3.49983966
55regulation of ligase activity (GO:0051340)3.45702498
56DNA methylation involved in gamete generation (GO:0043046)3.44362080
57DNA catabolic process, exonucleolytic (GO:0000738)3.43221984
58sister chromatid segregation (GO:0000819)3.42693862
59IMP biosynthetic process (GO:0006188)3.41414351
60protein neddylation (GO:0045116)3.37693178
61spindle checkpoint (GO:0031577)3.35482396
62meiosis I (GO:0007127)3.31092327
63mitotic spindle checkpoint (GO:0071174)3.28885213
64protein localization to kinetochore (GO:0034501)3.27673947
65protein K11-linked ubiquitination (GO:0070979)3.26838231
66pore complex assembly (GO:0046931)3.25553982
67telomere maintenance via semi-conservative replication (GO:0032201)3.24363477
68regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.23017814
69regulation of mitotic spindle checkpoint (GO:1903504)3.23017814
70regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.22294675
71response to X-ray (GO:0010165)3.21811347
72axonemal dynein complex assembly (GO:0070286)3.19831203
73IMP metabolic process (GO:0046040)3.19509673
74establishment of chromosome localization (GO:0051303)3.19043969
75nucleobase biosynthetic process (GO:0046112)3.15659302
76single fertilization (GO:0007338)3.15641495
77deoxyribonucleotide biosynthetic process (GO:0009263)3.13959502
78non-recombinational repair (GO:0000726)3.13614630
79double-strand break repair via nonhomologous end joining (GO:0006303)3.13614630
80acrosome reaction (GO:0007340)3.11718306
81mitotic nuclear envelope disassembly (GO:0007077)3.10710035
82negative regulation of protein ubiquitination (GO:0031397)3.06955204
83mitotic chromosome condensation (GO:0007076)3.06846477
84DNA replication-independent nucleosome assembly (GO:0006336)3.06311546
85DNA replication-independent nucleosome organization (GO:0034724)3.06311546
86mitotic G2/M transition checkpoint (GO:0044818)3.03532781
87positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.03302148
88positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.03302148
89positive regulation of mitotic sister chromatid separation (GO:1901970)3.03302148
90negative regulation of mitotic sister chromatid separation (GO:2000816)3.03099535
91negative regulation of sister chromatid segregation (GO:0033046)3.03099535
92negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.03099535
93negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.03099535
94negative regulation of mitotic sister chromatid segregation (GO:0033048)3.03099535
95G1/S transition of mitotic cell cycle (GO:0000082)3.01537327
96cell cycle G1/S phase transition (GO:0044843)3.01537327
97epithelial cilium movement (GO:0003351)3.01513252
98spindle assembly checkpoint (GO:0071173)3.01456686
99nuclear envelope disassembly (GO:0051081)3.00351913
100membrane disassembly (GO:0030397)3.00351913
101metaphase plate congression (GO:0051310)3.00056208
102mitotic spindle assembly checkpoint (GO:0007094)2.99612865
103mitotic recombination (GO:0006312)2.98816424
104DNA replication checkpoint (GO:0000076)2.97929546
105histone-serine phosphorylation (GO:0035404)2.97917834
106DNA replication-dependent nucleosome organization (GO:0034723)2.96387425
107DNA replication-dependent nucleosome assembly (GO:0006335)2.96387425
108regulation of centriole replication (GO:0046599)2.95941272
109DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.95836423
110neutrophil activation involved in immune response (GO:0002283)2.95361812
111gene silencing by RNA (GO:0031047)2.94657411
112regulation of helicase activity (GO:0051095)2.94057861
113meiotic cell cycle process (GO:1903046)2.93813761
114negative regulation of chromosome segregation (GO:0051985)2.93641574
115tRNA aminoacylation for protein translation (GO:0006418)2.93587755
116meiotic cell cycle (GO:0051321)2.92310619
117regulation of spindle organization (GO:0090224)2.91547317
118mitotic sister chromatid cohesion (GO:0007064)2.90961461
119somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.90468353
120somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.90468353
121isotype switching (GO:0045190)2.90468353
122negative regulation of protein modification by small protein conjugation or removal (GO:1903321)2.89658316
123amino acid activation (GO:0043038)2.88857470
124tRNA aminoacylation (GO:0043039)2.88857470
125DNA strand elongation involved in DNA replication (GO:0006271)2.87718269
126AMP metabolic process (GO:0046033)2.86875349
127formation of translation preinitiation complex (GO:0001731)2.84362874
128histone exchange (GO:0043486)2.82770170
129positive regulation of chromosome segregation (GO:0051984)2.81695176
130natural killer cell mediated immunity (GO:0002228)2.81131684
131natural killer cell mediated cytotoxicity (GO:0042267)2.81131684
132regulation of sister chromatid segregation (GO:0033045)2.80126080
133regulation of mitotic sister chromatid separation (GO:0010965)2.80126080
134regulation of mitotic sister chromatid segregation (GO:0033047)2.80126080
135microtubule depolymerization (GO:0007019)2.80112957
136DNA strand elongation (GO:0022616)2.78888479
137regulation of cellular amine metabolic process (GO:0033238)2.78490675
138fertilization (GO:0009566)2.78183355
139antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.77908628
140chromosome condensation (GO:0030261)2.77623680
141nucleobase-containing small molecule interconversion (GO:0015949)2.77545395
1427-methylguanosine mRNA capping (GO:0006370)2.77520107
143sister chromatid cohesion (GO:0007062)2.74217108
144mitotic sister chromatid segregation (GO:0000070)2.72397590
145regulation of cilium movement (GO:0003352)2.68531646
146meiotic chromosome segregation (GO:0045132)2.67454281
147regulation of chromosome segregation (GO:0051983)2.64515697
148sperm capacitation (GO:0048240)2.64421019
149immunoglobulin mediated immune response (GO:0016064)2.63865635
150purine nucleobase biosynthetic process (GO:0009113)2.62484647
151kinetochore organization (GO:0051383)2.61655203
152regulation of centrosome cycle (GO:0046605)2.61351823
153chromatin remodeling at centromere (GO:0031055)2.60621223
154positive regulation of protein import into nucleus, translocation (GO:0033160)2.60494267
155tricarboxylic acid cycle (GO:0006099)2.57130196
156regulation of mitotic spindle organization (GO:0060236)2.54481885
157DNA packaging (GO:0006323)2.52374014
158regulation of mitotic metaphase/anaphase transition (GO:0030071)2.51443548
159reciprocal meiotic recombination (GO:0007131)2.51014563
160reciprocal DNA recombination (GO:0035825)2.51014563
161modulation by symbiont of host immune response (GO:0052553)2.50145422
162positive regulation by symbiont of host defense response (GO:0052509)2.50145422
163modulation by symbiont of host defense response (GO:0052031)2.50145422
164modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.50145422
165modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.50145422
166positive regulation by organism of defense response of other organism involved in symbiotic interact2.50145422
167regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.46651336
168positive regulation of interferon-alpha production (GO:0032727)2.46391098
169B cell mediated immunity (GO:0019724)2.45948693
170regulation of interferon-beta biosynthetic process (GO:0045357)2.45106943
171telomere maintenance via recombination (GO:0000722)2.44541562
172postreplication repair (GO:0006301)2.44424430
173CENP-A containing nucleosome assembly (GO:0034080)2.44134679
174maturation of 5.8S rRNA (GO:0000460)2.43970419
175motile cilium assembly (GO:0044458)2.42922421
176spermatogenesis (GO:0007283)2.42553825
177male gamete generation (GO:0048232)2.42303849
178antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.41152336
179chaperone-mediated protein complex assembly (GO:0051131)2.40944758

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse6.11304617
2E2F7_22180533_ChIP-Seq_HELA_Human5.72346726
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.70172888
4* IRF8_21731497_ChIP-ChIP_J774_Mouse3.31838036
5E2F4_17652178_ChIP-ChIP_JURKAT_Human2.85774952
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.62034437
7AR_21909140_ChIP-Seq_LNCAP_Human2.47028143
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.44071772
9CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.35685304
10CREB1_15753290_ChIP-ChIP_HEK293T_Human2.35153448
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.05635095
12IRF8_22096565_ChIP-ChIP_GC-B_Human2.03145845
13SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.01842515
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.01095084
15BP1_19119308_ChIP-ChIP_Hs578T_Human2.00406086
16MYB_21317192_ChIP-Seq_ERMYB_Mouse1.94199489
17EST1_17652178_ChIP-ChIP_JURKAT_Human1.91898922
18ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.90297267
19EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.89336411
20PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.87478454
21EGR1_19374776_ChIP-ChIP_THP-1_Human1.86675739
22NELFA_20434984_ChIP-Seq_ESCs_Mouse1.85097491
23TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.83731023
24* IRF8_27001747_Chip-Seq_BMDM_Mouse1.80673018
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.80052629
26JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.78963573
27* IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.78409659
28POU3F2_20337985_ChIP-ChIP_501MEL_Human1.76912327
29HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.72926957
30TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.69636538
31* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.64902700
32KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.60799456
33MYC_19030024_ChIP-ChIP_MESCs_Mouse1.60583734
34* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.59547341
35DCP1A_22483619_ChIP-Seq_HELA_Human1.58618802
36ELK1_19687146_ChIP-ChIP_HELA_Human1.57540898
37E2F1_21310950_ChIP-Seq_MCF-7_Human1.56007941
38VDR_23849224_ChIP-Seq_CD4+_Human1.55460453
39* TFEB_21752829_ChIP-Seq_HELA_Human1.55446885
40MYCN_18555785_ChIP-Seq_MESCs_Mouse1.54569846
41SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.52159691
42MYC_18358816_ChIP-ChIP_MESCs_Mouse1.51712873
43ETS1_20019798_ChIP-Seq_JURKAT_Human1.49652648
44EWS_26573619_Chip-Seq_HEK293_Human1.47185950
45THAP11_20581084_ChIP-Seq_MESCs_Mouse1.44440549
46YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.43728504
47* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.42006797
48TTF2_22483619_ChIP-Seq_HELA_Human1.40901856
49* SPI1_23547873_ChIP-Seq_NB4_Human1.38817094
50HOXB4_20404135_ChIP-ChIP_EML_Mouse1.38465127
51MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.37993966
52HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.35881378
53* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.34745286
54* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.30321701
55PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.30052336
56STAT3_1855785_ChIP-Seq_MESCs_Mouse1.29511268
57SALL1_21062744_ChIP-ChIP_HESCs_Human1.28964061
58RBPJ_22232070_ChIP-Seq_NCS_Mouse1.27890079
59POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.27092039
60PADI4_21655091_ChIP-ChIP_MCF-7_Human1.26647768
61STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.26493167
62MYC_19079543_ChIP-ChIP_MESCs_Mouse1.25423850
63IGF1R_20145208_ChIP-Seq_DFB_Human1.24965594
64ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.24729557
65FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.22939235
66* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.21177088
67SOX17_20123909_ChIP-Seq_XEN_Mouse1.20579929
68FUS_26573619_Chip-Seq_HEK293_Human1.19893227
69FOXP3_21729870_ChIP-Seq_TREG_Human1.19863438
70KAP1_22055183_ChIP-Seq_ESCs_Mouse1.19241660
71MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.17606174
72FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.17291340
73ELK1_22589737_ChIP-Seq_MCF10A_Human1.17103753
74* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15419301
75GABP_19822575_ChIP-Seq_HepG2_Human1.15265357
76* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.14777099
77WT1_19549856_ChIP-ChIP_CCG9911_Human1.14324747
78MYC_18940864_ChIP-ChIP_HL60_Human1.14291671
79RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.12504289
80* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.10672511
81PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10136288
82ELF1_17652178_ChIP-ChIP_JURKAT_Human1.09606509
83SRF_21415370_ChIP-Seq_HL-1_Mouse1.09603358
84E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.08276978
85CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.07949986
86SMAD_19615063_ChIP-ChIP_OVARY_Human1.07847491
87NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.05599424
88* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.05147662
89FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.03868781
90KDM5A_27292631_Chip-Seq_BREAST_Human1.03112331
91NANOG_18555785_ChIP-Seq_MESCs_Mouse1.02838884
92NANOG_16153702_ChIP-ChIP_HESCs_Human1.02029878
93SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.98761891
94ELF5_23300383_ChIP-Seq_T47D_Human0.98622521
95BRD4_25478319_ChIP-Seq_HGPS_Human0.98534808
96XRN2_22483619_ChIP-Seq_HELA_Human0.98268624
97CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.96568411
98* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96221509
99TAF15_26573619_Chip-Seq_HEK293_Human0.94243481
100MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.94085996
101FLI1_27457419_Chip-Seq_LIVER_Mouse0.93535791
102* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.92635391
103NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.92486893
104ERG_20887958_ChIP-Seq_HPC-7_Mouse0.92218095
105* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91297096
106EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.89592586
107* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.89559647
108CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.89286727
109NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.88705463
110CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.88123364
111* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.87152763
112GATA3_26560356_Chip-Seq_TH2_Human0.87057500
113PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86856106
114* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.86835356
115* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.86643292
116VDR_22108803_ChIP-Seq_LS180_Human0.86256828
117* PU_27001747_Chip-Seq_BMDM_Mouse0.86189122
118PCGF2_27294783_Chip-Seq_ESCs_Mouse0.85523037
119EZH2_27294783_Chip-Seq_NPCs_Mouse0.84878563
120* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84598730
121ZFP57_27257070_Chip-Seq_ESCs_Mouse0.83572985
122TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.83180856
123BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.82964373
124PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.82581438
125SALL4_18804426_ChIP-ChIP_XEN_Mouse0.82340539
126MYB_26560356_Chip-Seq_TH2_Human0.81381913
127NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.80275420
128ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.80176764
129NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.79244422
130HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.78732969
131BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.77565249
132FOXM1_26456572_ChIP-Seq_MCF-7_Human0.77412937
133IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.77275601
134SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.77206120
135P300_19829295_ChIP-Seq_ESCs_Human0.77195728
136ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.76946538
137POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.76790073
138SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.76162388
139SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.76162388
140HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.75898884

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization4.38025970
2MP0003806_abnormal_nucleotide_metabolis4.29770645
3MP0008877_abnormal_DNA_methylation3.15080298
4MP0010234_abnormal_vibrissa_follicle3.00096730
5MP0010094_abnormal_chromosome_stability2.78214991
6MP0008438_abnormal_cutaneous_collagen2.63938736
7MP0003693_abnormal_embryo_hatching2.37474796
8MP0003941_abnormal_skin_development2.35200559
9MP0005058_abnormal_lysosome_morphology2.33137258
10MP0010307_abnormal_tumor_latency2.32874731
11MP0004957_abnormal_blastocyst_morpholog2.30192344
12MP0008007_abnormal_cellular_replicative2.29599128
13MP0003111_abnormal_nucleus_morphology2.21117099
14MP0001929_abnormal_gametogenesis2.19970461
15MP0003077_abnormal_cell_cycle2.18852620
16MP0004147_increased_porphyrin_level2.18443858
17MP0008057_abnormal_DNA_replication2.17140284
18MP0006036_abnormal_mitochondrial_physio2.07420812
19MP0003705_abnormal_hypodermis_morpholog1.91408063
20MP0002210_abnormal_sex_determination1.84190288
21MP0003436_decreased_susceptibility_to1.80969053
22MP0001835_abnormal_antigen_presentation1.79090785
23MP0005408_hypopigmentation1.76553284
24MP0010352_gastrointestinal_tract_polyps1.75659698
25MP0003698_abnormal_male_reproductive1.70775369
26MP0003646_muscle_fatigue1.67487113
27MP0006035_abnormal_mitochondrial_morpho1.63438259
28MP0005084_abnormal_gallbladder_morpholo1.63127181
29MP0002148_abnormal_hypersensitivity_rea1.59007669
30MP0002419_abnormal_innate_immunity1.51726246
31MP0002090_abnormal_vision1.51471840
32MP0002102_abnormal_ear_morphology1.51255259
33MP0003448_altered_tumor_morphology1.48638476
34MP0009785_altered_susceptibility_to1.48403336
35MP0001145_abnormal_male_reproductive1.48188820
36MP0003890_abnormal_embryonic-extraembry1.47981256
37MP0001545_abnormal_hematopoietic_system1.47792888
38MP0005397_hematopoietic_system_phenotyp1.47792888
39MP0008058_abnormal_DNA_repair1.47567075
40MP0004782_abnormal_surfactant_physiolog1.45364521
41MP0000647_abnormal_sebaceous_gland1.43457980
42MP0001529_abnormal_vocalization1.43080756
43MP0002796_impaired_skin_barrier1.41983956
44MP0001293_anophthalmia1.41780029
45MP0000372_irregular_coat_pigmentation1.41416711
46MP0000343_altered_response_to1.40732946
47MP0003186_abnormal_redox_activity1.37291660
48MP0005623_abnormal_meninges_morphology1.35918656
49MP0001727_abnormal_embryo_implantation1.32982482
50MP0002877_abnormal_melanocyte_morpholog1.31636767
51MP0006054_spinal_hemorrhage1.31197904
52MP0005275_abnormal_skin_tensile1.30625967
53MP0000653_abnormal_sex_gland1.28640752
54MP0000858_altered_metastatic_potential1.27564089
55MP0008932_abnormal_embryonic_tissue1.26526896
56MP0003718_maternal_effect1.26325720
57MP0003786_premature_aging1.24169567
58MP0005501_abnormal_skin_physiology1.22443273
59MP0000350_abnormal_cell_proliferation1.22358032
60MP0003566_abnormal_cell_adhesion1.21130503
61MP0004084_abnormal_cardiac_muscle1.19870066
62MP0005075_abnormal_melanosome_morpholog1.19295929
63MP0003303_peritoneal_inflammation1.18440043
64MP0003221_abnormal_cardiomyocyte_apopto1.17282541
65MP0003195_calcinosis1.16812705
66MP0009840_abnormal_foam_cell1.14736144
67MP0000569_abnormal_digit_pigmentation1.14147330
68MP0002161_abnormal_fertility/fecundity1.12804001
69MP0002452_abnormal_antigen_presenting1.12077172
70MP0004215_abnormal_myocardial_fiber1.12044806
71MP0005000_abnormal_immune_tolerance1.11075170
72* MP0001730_embryonic_growth_arrest1.10984713
73MP0002938_white_spotting1.08820689
74MP0010678_abnormal_skin_adnexa1.08268702
75MP0001533_abnormal_skeleton_physiology1.06641705
76MP0005025_abnormal_response_to1.06573832
77MP0004808_abnormal_hematopoietic_stem1.06418732
78MP0003567_abnormal_fetal_cardiomyocyte1.05312284
79MP0002234_abnormal_pharynx_morphology1.04865975
80MP0001958_emphysema1.03290144
81MP0005023_abnormal_wound_healing1.02506902
82MP0003656_abnormal_erythrocyte_physiolo1.01844585
83MP0001881_abnormal_mammary_gland1.00793574
84MP0008789_abnormal_olfactory_epithelium0.99840417
85MP0004947_skin_inflammation0.99329669
86MP0001853_heart_inflammation0.98100237
87MP0002160_abnormal_reproductive_system0.97570008
88MP0001697_abnormal_embryo_size0.97237297
89MP0003011_delayed_dark_adaptation0.96057341
90MP0005076_abnormal_cell_differentiation0.96004766
91MP0001299_abnormal_eye_distance/0.95838081
92MP0000427_abnormal_hair_cycle0.95499109
93MP0002019_abnormal_tumor_incidence0.95311634
94MP0000015_abnormal_ear_pigmentation0.94223747
95MP0002396_abnormal_hematopoietic_system0.93807593
96MP0003828_pulmonary_edema0.93170363
97MP0009333_abnormal_splenocyte_physiolog0.93035559
98MP0001216_abnormal_epidermal_layer0.92776599
99MP0000358_abnormal_cell_content/0.92482877
100MP0001119_abnormal_female_reproductive0.91983028
101MP0005257_abnormal_intraocular_pressure0.90286421
102MP0001764_abnormal_homeostasis0.89092307
103MP0005384_cellular_phenotype0.88907712
104MP0000313_abnormal_cell_death0.88395444
105MP0006082_CNS_inflammation0.87649442
106* MP0002084_abnormal_developmental_patter0.87290713
107MP0003724_increased_susceptibility_to0.86358945
108MP0001845_abnormal_inflammatory_respons0.86267919
109MP0002405_respiratory_system_inflammati0.85955446
110MP0001191_abnormal_skin_condition0.85591210
111MP0006072_abnormal_retinal_apoptosis0.85359008
112MP0005395_other_phenotype0.85078917
113MP0003279_aneurysm0.83969484
114MP0005174_abnormal_tail_pigmentation0.83836067
115MP0002723_abnormal_immune_serum0.83806230
116MP0009697_abnormal_copulation0.83293897
117MP0002060_abnormal_skin_morphology0.81925039
118MP0009764_decreased_sensitivity_to0.81783840
119* MP0002085_abnormal_embryonic_tissue0.80909945
120MP0000689_abnormal_spleen_morphology0.80892479
121MP0005389_reproductive_system_phenotype0.80248137
122MP0001819_abnormal_immune_cell0.80197889
123MP0002095_abnormal_skin_pigmentation0.80051024
124MP0003950_abnormal_plasma_membrane0.79537996
125MP0009278_abnormal_bone_marrow0.79453333
126MP0002420_abnormal_adaptive_immunity0.78906369
127MP0004272_abnormal_basement_membrane0.78741525
128MP0000371_diluted_coat_color0.78493363
129* MP0003984_embryonic_growth_retardation0.78437956
130MP0001243_abnormal_dermal_layer0.78056068
131MP0002177_abnormal_outer_ear0.78038209
132* MP0001672_abnormal_embryogenesis/_devel0.77836203
133* MP0005380_embryogenesis_phenotype0.77836203
134MP0001800_abnormal_humoral_immune0.77380227
135MP0000516_abnormal_urinary_system0.76887615
136MP0005367_renal/urinary_system_phenotyp0.76887615
137* MP0002088_abnormal_embryonic_growth/wei0.76470111
138* MP0002086_abnormal_extraembryonic_tissu0.76153463
139MP0005197_abnormal_uvea_morphology0.75696176
140* MP0002080_prenatal_lethality0.73973177
141MP0001542_abnormal_bone_strength0.73953646
142MP0003123_paternal_imprinting0.73742961
143MP0008004_abnormal_stomach_pH0.73701839
144MP0005464_abnormal_platelet_physiology0.73440650
145MP0001915_intracranial_hemorrhage0.73083750
146MP0002295_abnormal_pulmonary_circulatio0.72318128
147MP0008469_abnormal_protein_level0.71998030
148MP0002233_abnormal_nose_morphology0.70379703
149MP0008260_abnormal_autophagy0.69690316
150MP0005621_abnormal_cell_physiology0.68534782
151MP0003937_abnormal_limbs/digits/tail_de0.68312109
152MP0008873_increased_physiological_sensi0.68033612
153MP0004197_abnormal_fetal_growth/weight/0.67006438
154MP0002092_abnormal_eye_morphology0.66804008
155MP0000627_abnormal_mammary_gland0.66446621
156MP0002269_muscular_atrophy0.65493197
157MP0000749_muscle_degeneration0.64414443
158MP0001186_pigmentation_phenotype0.63249536

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.58418544
2Absent/shortened dynein arms (HP:0200106)4.30886469
3Dynein arm defect of respiratory motile cilia (HP:0012255)4.30886469
4Recurrent abscess formation (HP:0002722)3.99780972
5Abnormality of the anterior horn cell (HP:0006802)3.79233124
6Degeneration of anterior horn cells (HP:0002398)3.79233124
7Recurrent bacterial skin infections (HP:0005406)3.76416630
8Increased serum pyruvate (HP:0003542)3.75328321
9Recurrent gram-negative bacterial infections (HP:0005420)3.50027863
10Abnormality of glycolysis (HP:0004366)3.47621833
11Abnormal spermatogenesis (HP:0008669)3.46955060
12Rhinitis (HP:0012384)3.44648177
13Chronic bronchitis (HP:0004469)3.33843720
14Abnormal respiratory motile cilium physiology (HP:0012261)3.31055341
15Nasal polyposis (HP:0100582)3.21011690
16Infertility (HP:0000789)3.20849779
17Agnosia (HP:0010524)3.13961944
18Abnormality of the vasculature of the conjunctiva (HP:0008054)3.11481708
19Hypoplastic pelvis (HP:0008839)3.10352348
20Azoospermia (HP:0000027)3.07474452
21Eczematoid dermatitis (HP:0000976)3.06507419
22Abnormality of chromosome stability (HP:0003220)2.97889875
23Acute necrotizing encephalopathy (HP:0006965)2.94874676
24Disinhibition (HP:0000734)2.94081254
25Conjunctival telangiectasia (HP:0000524)2.91041450
26Abnormal mitochondria in muscle tissue (HP:0008316)2.90671262
27Male infertility (HP:0003251)2.90275136
28Tongue fasciculations (HP:0001308)2.87045681
29Posterior subcapsular cataract (HP:0007787)2.86990003
30Increased CSF lactate (HP:0002490)2.81944046
31Osteolytic defects of the hand bones (HP:0009699)2.81680997
32Osteolytic defects of the phalanges of the hand (HP:0009771)2.81680997
33Decreased activity of mitochondrial respiratory chain (HP:0008972)2.78649539
34Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.78649539
35Premature rupture of membranes (HP:0001788)2.75478331
36Upper motor neuron abnormality (HP:0002127)2.75403423
37Increased cerebral lipofuscin (HP:0011813)2.72378892
38Sparse eyelashes (HP:0000653)2.71714616
39Acute encephalopathy (HP:0006846)2.71165927
40Systemic lupus erythematosus (HP:0002725)2.69502775
41Muscle fibrillation (HP:0010546)2.68325407
42Impulsivity (HP:0100710)2.65936303
43Abnormality of the nasal mucosa (HP:0000433)2.63617127
44Abnormal respiratory epithelium morphology (HP:0012253)2.61468552
45Abnormal respiratory motile cilium morphology (HP:0005938)2.61468552
46Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.61205485
47Vacuolated lymphocytes (HP:0001922)2.60792056
48Neoplasm of head and neck (HP:0012288)2.59992776
49Esophageal neoplasm (HP:0100751)2.59992776
50Progressive macrocephaly (HP:0004481)2.58407157
51Chromsome breakage (HP:0040012)2.56616114
52Abnormal lung lobation (HP:0002101)2.54489290
53Cortical dysplasia (HP:0002539)2.53430613
543-Methylglutaconic aciduria (HP:0003535)2.49959098
55Increased neuronal autofluorescent lipopigment (HP:0002074)2.49243903
56Hepatocellular necrosis (HP:0001404)2.47595615
57Birth length less than 3rd percentile (HP:0003561)2.47583628
58Mitochondrial inheritance (HP:0001427)2.46847471
59Abnormality of methionine metabolism (HP:0010901)2.45106666
60Abnormality of macrophages (HP:0004311)2.43853018
61Meckel diverticulum (HP:0002245)2.43603014
62Spinal muscular atrophy (HP:0007269)2.43580692
63Aplasia/Hypoplasia of the uvula (HP:0010293)2.42787791
64Cutaneous melanoma (HP:0012056)2.42529588
65Bronchitis (HP:0012387)2.42404597
66Hepatic necrosis (HP:0002605)2.40922477
67Mediastinal lymphadenopathy (HP:0100721)2.39982304
6811 pairs of ribs (HP:0000878)2.37977397
69Type I transferrin isoform profile (HP:0003642)2.37291441
70Volvulus (HP:0002580)2.34215054
71Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.33362982
72Abnormal protein N-linked glycosylation (HP:0012347)2.33362982
73Abnormal protein glycosylation (HP:0012346)2.33362982
74Abnormal glycosylation (HP:0012345)2.33362982
75Ependymoma (HP:0002888)2.32637875
76Reduced subcutaneous adipose tissue (HP:0003758)2.32169470
77Methylmalonic acidemia (HP:0002912)2.31754630
78Poor head control (HP:0002421)2.30772859
79Increased serum lactate (HP:0002151)2.30176130
80Exercise-induced muscle cramps (HP:0003710)2.28621177
81Abnormal auditory evoked potentials (HP:0006958)2.27934446
82Nausea (HP:0002018)2.27858624
83Metaphyseal cupping (HP:0003021)2.26959564
84Abnormality of the ileum (HP:0001549)2.25585650
85Increased hepatocellular lipid droplets (HP:0006565)2.24804451
86Abnormality of the preputium (HP:0100587)2.24535058
87Postnatal microcephaly (HP:0005484)2.23362704
88Hypoplasia of the capital femoral epiphysis (HP:0003090)2.22889227
89Mucosal telangiectasiae (HP:0100579)2.22887821
90Palpitations (HP:0001962)2.21980458
91Vertebral compression fractures (HP:0002953)2.20602029
92Sloping forehead (HP:0000340)2.20598987
93Autoamputation (HP:0001218)2.19465349
94Cervical subluxation (HP:0003308)2.16077727
95Abnormality of placental membranes (HP:0011409)2.15651551
96Amniotic constriction ring (HP:0009775)2.15651551
97Absent frontal sinuses (HP:0002688)2.14965107
98Atrophy/Degeneration involving motor neurons (HP:0007373)2.12721206
99Neoplasm of the colon (HP:0100273)2.12679508
100Myositis (HP:0100614)2.12416987
101Biliary tract neoplasm (HP:0100574)2.10383722
102Ureteral duplication (HP:0000073)2.09795074
103Short nail (HP:0001799)2.09713198
104Myelodysplasia (HP:0002863)2.07484662
105Abnormal ciliary motility (HP:0012262)2.07245706
106Rhabdomyosarcoma (HP:0002859)2.06441975
107J-shaped sella turcica (HP:0002680)2.05582282
108Adrenal hypoplasia (HP:0000835)2.05238008
109Lactic acidosis (HP:0003128)2.05135591
110Abnormality of the umbilical cord (HP:0010881)2.03499346
111Bronchiectasis (HP:0002110)2.03167714
112Selective tooth agenesis (HP:0001592)2.02147149
113Cerebral edema (HP:0002181)2.02055565
114Abnormalities of placenta or umbilical cord (HP:0001194)2.01846111
115Tetraparesis (HP:0002273)2.01084967
116Chromosomal breakage induced by crosslinking agents (HP:0003221)2.00956695
117Abnormality of aspartate family amino acid metabolism (HP:0010899)2.00816354
118Ankle contracture (HP:0006466)2.00741887
119Clubbing of toes (HP:0100760)1.99968935
120Short middle phalanx of the 5th finger (HP:0004220)1.98220909
121Methylmalonic aciduria (HP:0012120)1.98075623
122Glioma (HP:0009733)1.97955490
123Personality changes (HP:0000751)1.96810879
124Renal Fanconi syndrome (HP:0001994)1.96713884
125Medulloblastoma (HP:0002885)1.96622314
126Colon cancer (HP:0003003)1.96168301
127Abnormality of the fetal cardiovascular system (HP:0010948)1.95699619
128Abnormal umbilical cord blood vessels (HP:0011403)1.95699619
129Single umbilical artery (HP:0001195)1.95699619
130High pitched voice (HP:0001620)1.95256524
131Acute myeloid leukemia (HP:0004808)1.94623149
132Molar tooth sign on MRI (HP:0002419)1.94296945
133Abnormality of midbrain morphology (HP:0002418)1.94296945
134Duodenal stenosis (HP:0100867)1.94269017
135Small intestinal stenosis (HP:0012848)1.94269017
136Ovarian neoplasm (HP:0100615)1.93646246
137Median cleft lip (HP:0000161)1.93639593
138CNS demyelination (HP:0007305)1.93038335
139Hypokinesia (HP:0002375)1.91040282
140Neoplasm of the small intestine (HP:0100833)1.90208948
141Progressive inability to walk (HP:0002505)1.89050607
142Microglossia (HP:0000171)1.88776394
143Multiple enchondromatosis (HP:0005701)1.87841611
144Lipid accumulation in hepatocytes (HP:0006561)1.87719496
145Exertional dyspnea (HP:0002875)1.87053108
146Myocardial infarction (HP:0001658)1.86778469
147Respiratory failure (HP:0002878)1.85967971
148Bone marrow hypocellularity (HP:0005528)1.84936026
149Autoimmune thrombocytopenia (HP:0001973)1.84899908
150Freckling (HP:0001480)1.84350660
151Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.83923919
152Asymmetric septal hypertrophy (HP:0001670)1.83683374
153Breast hypoplasia (HP:0003187)1.83231052
154Prolonged neonatal jaundice (HP:0006579)1.83192056
155Recurrent bronchitis (HP:0002837)1.81445182
156Nephronophthisis (HP:0000090)1.81309946
157Gonadotropin excess (HP:0000837)1.80240339
158Orchitis (HP:0100796)1.79950587
159Congenital ichthyosiform erythroderma (HP:0007431)1.79202597
160Microvesicular hepatic steatosis (HP:0001414)1.78815845
161Delayed gross motor development (HP:0002194)1.78663842
162Abnormality of alanine metabolism (HP:0010916)1.77706274
163Hyperalaninemia (HP:0003348)1.77706274
164Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.77706274
165Abnormality of serum amino acid levels (HP:0003112)1.76225786
166Embryonal renal neoplasm (HP:0011794)1.75530621
167Sensory axonal neuropathy (HP:0003390)1.74993503
168B lymphocytopenia (HP:0010976)1.74168975
169Breast carcinoma (HP:0003002)1.73798460
170Hepatosplenomegaly (HP:0001433)1.73229934
171Absent thumb (HP:0009777)1.73069599
172Protrusio acetabuli (HP:0003179)1.72511890
173Ectopic kidney (HP:0000086)1.71655237
174Neoplasm of the rectum (HP:0100743)1.68215440
175Peritonitis (HP:0002586)1.66331164

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK45.77773481
2PDK35.77773481
3PDK23.97508905
4TRIM283.35411926
5BRSK23.09429473
6WEE12.97729667
7TESK12.86177903
8BUB12.72746447
9BCR2.49020582
10EIF2AK12.18025606
11NEK22.13026358
12CDC72.10486923
13SIK32.02112030
14NEK12.02077740
15NEK92.01381053
16PLK41.95464222
17BLK1.95317363
18TTK1.75865391
19MKNK11.75045872
20MAP3K121.74765012
21NUAK11.74622159
22VRK21.72072775
23PBK1.67822041
24STK101.66420375
25MKNK21.60763568
26ACVR1B1.53304141
27STK31.45825800
28STK161.40778203
29PLK11.37298362
30WNK31.36709143
31CCNB11.36592447
32LATS11.32012858
33KIT1.30117851
34LIMK11.27679976
35BCKDK1.20925602
36PLK31.20483000
37TESK21.17339684
38RPS6KA41.16149675
39TTN1.15681629
40BRSK11.12035206
41CHEK21.10399210
42STK41.04784775
43IRAK41.04353669
44PTK2B1.01848489
45TSSK61.00833196
46CSNK1G31.00136971
47TBK10.98421213
48STK38L0.97824686
49CSNK1A1L0.96289548
50EIF2AK30.94232655
51ATR0.91908263
52WNK40.89931230
53CSNK1G10.89036250
54TRPM70.88824968
55CSNK1G20.87781870
56KSR10.86939320
57AURKB0.85511277
58TYK20.85033103
59ABL20.83558376
60PAK40.83466426
61MYLK0.79072544
62MAP3K60.78580488
63SCYL20.78107617
64MAP3K50.77616864
65TAF10.75795746
66CDK60.74628618
67SRPK10.74085027
68MST40.73641918
69IRAK30.72415711
70STK240.72059900
71ZAP700.70931957
72TRIB30.69304496
73TNIK0.68658702
74MAP3K140.67011826
75CSF1R0.66844269
76MARK30.66006110
77CDK80.64003686
78MINK10.63874390
79PLK20.63716319
80MET0.60206733
81EPHA20.59722569
82CHEK10.59575670
83NME20.58566893
84ERBB40.58409368
85CDK40.57486641
86PIM20.56813842
87ERBB30.56712414
88BRAF0.56600100
89MAP3K80.56512575
90MAP4K20.55949402
91BMPR20.55034844
92CLK10.54354823
93MST1R0.53648311
94JAK30.52135469
95PASK0.51947254
96ATM0.51510247
97ARAF0.51252549
98PIM10.50004532
99MAP3K30.49438748
100EIF2AK20.49426159
101PAK10.49149930
102DYRK30.48399294
103GRK70.48288601
104RAF10.48033986
105ZAK0.47970165
106CDK70.46007933
107CHUK0.45839372
108MOS0.43581738
109IKBKB0.43492605
110TLK10.42833617
111FER0.42246908
112TGFBR20.41209659
113MAPKAPK30.39026326
114CDK180.38715661
115MAP2K30.37935230
116CSNK2A10.37874080
117TAOK30.37196113
118FLT30.36622281
119AURKA0.36400242
120CDK140.36101735
121BMPR1B0.36083466
122TGFBR10.34732343
123LRRK20.34484700
124BRD40.33505882
125OXSR10.32984934
126DAPK10.32822733
127NME10.32736475
128MATK0.32482064
129LATS20.31493712
130CDK90.31477255
131YES10.30942650
132CSNK2A20.30370084
133RIPK40.29180672
134LYN0.28798374
135STK390.28096024
136VRK10.27419510
137JAK10.26798924
138EEF2K0.25788328
139PDK10.25433593
140EGFR0.24165897

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.56123799
2Proteasome_Homo sapiens_hsa030502.84138321
3Homologous recombination_Homo sapiens_hsa034402.54652629
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.51649985
5Vitamin B6 metabolism_Homo sapiens_hsa007502.51086332
6DNA replication_Homo sapiens_hsa030302.43397781
7Pentose phosphate pathway_Homo sapiens_hsa000302.38099946
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.31695714
9Fatty acid elongation_Homo sapiens_hsa000622.18710764
10Mismatch repair_Homo sapiens_hsa034302.16676785
11Cell cycle_Homo sapiens_hsa041102.08414051
12Legionellosis_Homo sapiens_hsa051342.06197209
13RNA transport_Homo sapiens_hsa030132.06032988
14Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.04852584
15Fanconi anemia pathway_Homo sapiens_hsa034601.96324699
16Oxidative phosphorylation_Homo sapiens_hsa001901.91209893
17Basal transcription factors_Homo sapiens_hsa030221.90017491
18Antigen processing and presentation_Homo sapiens_hsa046121.78954121
19Glycosaminoglycan degradation_Homo sapiens_hsa005311.77925025
20Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.70816505
21Parkinsons disease_Homo sapiens_hsa050121.67920461
22Lysosome_Homo sapiens_hsa041421.59979128
23Carbon metabolism_Homo sapiens_hsa012001.59745295
24Steroid biosynthesis_Homo sapiens_hsa001001.57340752
25Nucleotide excision repair_Homo sapiens_hsa034201.55384454
26Base excision repair_Homo sapiens_hsa034101.55287825
27Other glycan degradation_Homo sapiens_hsa005111.55287244
28Staphylococcus aureus infection_Homo sapiens_hsa051501.52915885
29Phagosome_Homo sapiens_hsa041451.49935025
30p53 signaling pathway_Homo sapiens_hsa041151.49582262
31Pyruvate metabolism_Homo sapiens_hsa006201.46356601
32RNA polymerase_Homo sapiens_hsa030201.43856187
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.42261321
34RNA degradation_Homo sapiens_hsa030181.40071604
35Leishmaniasis_Homo sapiens_hsa051401.33198729
36Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.31845493
37Epstein-Barr virus infection_Homo sapiens_hsa051691.31325778
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.30307456
39Tuberculosis_Homo sapiens_hsa051521.27247744
40Renin-angiotensin system_Homo sapiens_hsa046141.23137325
41Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.23119313
42Biosynthesis of amino acids_Homo sapiens_hsa012301.22302663
43Non-homologous end-joining_Homo sapiens_hsa034501.21519425
44Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.21122080
45Propanoate metabolism_Homo sapiens_hsa006401.20995593
46Sulfur metabolism_Homo sapiens_hsa009201.19198182
47Pyrimidine metabolism_Homo sapiens_hsa002401.18555773
48Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.13202835
492-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.13119649
50Selenocompound metabolism_Homo sapiens_hsa004501.02588598
51Herpes simplex infection_Homo sapiens_hsa051681.00775604
52Alzheimers disease_Homo sapiens_hsa050101.00462968
53Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.00332161
54Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.98873325
55Viral carcinogenesis_Homo sapiens_hsa052030.98435283
56Rheumatoid arthritis_Homo sapiens_hsa053230.98112153
57One carbon pool by folate_Homo sapiens_hsa006700.97447536
58Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.95595511
59Spliceosome_Homo sapiens_hsa030400.95487370
60Malaria_Homo sapiens_hsa051440.94681065
61Influenza A_Homo sapiens_hsa051640.93243430
62Cysteine and methionine metabolism_Homo sapiens_hsa002700.92679560
63NOD-like receptor signaling pathway_Homo sapiens_hsa046210.92399066
64SNARE interactions in vesicular transport_Homo sapiens_hsa041300.87987745
65Toll-like receptor signaling pathway_Homo sapiens_hsa046200.87957744
66Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.87044639
67Osteoclast differentiation_Homo sapiens_hsa043800.86691950
68Measles_Homo sapiens_hsa051620.85830809
69Shigellosis_Homo sapiens_hsa051310.84873285
70Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.82171438
71Toxoplasmosis_Homo sapiens_hsa051450.81512363
72Graft-versus-host disease_Homo sapiens_hsa053320.78560312
73Apoptosis_Homo sapiens_hsa042100.76695474
74NF-kappa B signaling pathway_Homo sapiens_hsa040640.76038690
75Salmonella infection_Homo sapiens_hsa051320.75613960
76Vibrio cholerae infection_Homo sapiens_hsa051100.74479532
77Oocyte meiosis_Homo sapiens_hsa041140.73189430
78Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.72951710
79Pertussis_Homo sapiens_hsa051330.72505037
80Caffeine metabolism_Homo sapiens_hsa002320.71519314
81Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.69125479
82Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.68547354
83Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.68182808
84Glutathione metabolism_Homo sapiens_hsa004800.67925939
85Viral myocarditis_Homo sapiens_hsa054160.66394429
86Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.64844547
87Collecting duct acid secretion_Homo sapiens_hsa049660.63957654
88Systemic lupus erythematosus_Homo sapiens_hsa053220.63093763
89Purine metabolism_Homo sapiens_hsa002300.60474453
90N-Glycan biosynthesis_Homo sapiens_hsa005100.60329263
91Metabolic pathways_Homo sapiens_hsa011000.60294646
92Pentose and glucuronate interconversions_Homo sapiens_hsa000400.59844315
93Folate biosynthesis_Homo sapiens_hsa007900.59817652
94mRNA surveillance pathway_Homo sapiens_hsa030150.58151398
95Small cell lung cancer_Homo sapiens_hsa052220.57576559
96HIF-1 signaling pathway_Homo sapiens_hsa040660.55257503
97Peroxisome_Homo sapiens_hsa041460.54714288
98Regulation of autophagy_Homo sapiens_hsa041400.53345449
99Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.52397293
100Hepatitis B_Homo sapiens_hsa051610.52346046
101Fatty acid metabolism_Homo sapiens_hsa012120.51349059
102Fructose and mannose metabolism_Homo sapiens_hsa000510.51163443
103Sphingolipid metabolism_Homo sapiens_hsa006000.49130987
104TNF signaling pathway_Homo sapiens_hsa046680.47292522
105Amoebiasis_Homo sapiens_hsa051460.43897331
106Galactose metabolism_Homo sapiens_hsa000520.43345017
107Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43185411
108HTLV-I infection_Homo sapiens_hsa051660.42182318
109Huntingtons disease_Homo sapiens_hsa050160.41684097
110TGF-beta signaling pathway_Homo sapiens_hsa043500.41666912
111Circadian rhythm_Homo sapiens_hsa047100.41581108
112Primary bile acid biosynthesis_Homo sapiens_hsa001200.41283835
113Arginine and proline metabolism_Homo sapiens_hsa003300.36321405
114Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.36127386
115MicroRNAs in cancer_Homo sapiens_hsa052060.35705856
116beta-Alanine metabolism_Homo sapiens_hsa004100.35402508
117Drug metabolism - other enzymes_Homo sapiens_hsa009830.35304317
118Fatty acid degradation_Homo sapiens_hsa000710.34866639
119Pancreatic cancer_Homo sapiens_hsa052120.34191658
120Allograft rejection_Homo sapiens_hsa053300.32924320
121RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.32353965
122Mineral absorption_Homo sapiens_hsa049780.31648996
123Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.31409985
124Thyroid cancer_Homo sapiens_hsa052160.30982512
125Adherens junction_Homo sapiens_hsa045200.30332015
126Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.29722366
127Fatty acid biosynthesis_Homo sapiens_hsa000610.29467845
128Complement and coagulation cascades_Homo sapiens_hsa046100.29015652
129Leukocyte transendothelial migration_Homo sapiens_hsa046700.27981891
130Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.26531742
131Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.25553378
132Tryptophan metabolism_Homo sapiens_hsa003800.25014256
133Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.20363263
134Butanoate metabolism_Homo sapiens_hsa006500.18784762
135Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.14188610
136Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.10326770
137Hippo signaling pathway_Homo sapiens_hsa043900.09166515

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