VPS26AP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1opioid receptor signaling pathway (GO:0038003)9.97345510
2behavioral response to ethanol (GO:0048149)8.99680265
3negative regulation of calcium ion-dependent exocytosis (GO:0045955)8.82579805
4adult feeding behavior (GO:0008343)8.36480469
5regulation of translational termination (GO:0006449)8.18703222
6regulation of acrosome reaction (GO:0060046)7.39067353
7regulation of protein glycosylation (GO:0060049)7.08347003
8adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)6.75316019
9positive regulation of cAMP-mediated signaling (GO:0043950)6.42971296
10glycerol ether metabolic process (GO:0006662)6.17149526
11negative regulation of nitric oxide biosynthetic process (GO:0045019)5.99068083
12thrombin receptor signaling pathway (GO:0070493)5.97863671
13DNA replication-dependent nucleosome assembly (GO:0006335)5.94594990
14DNA replication-dependent nucleosome organization (GO:0034723)5.94594990
15piRNA metabolic process (GO:0034587)5.94303713
16sphingosine metabolic process (GO:0006670)5.92666835
17ether metabolic process (GO:0018904)5.71044954
18diol metabolic process (GO:0034311)5.43934046
19sphingoid metabolic process (GO:0046519)5.22321618
20response to pheromone (GO:0019236)5.17166837
21notochord development (GO:0030903)4.99776130
22negative regulation of glycoprotein biosynthetic process (GO:0010561)4.97129887
23regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.91244568
24cellular response to ammonium ion (GO:0071242)4.67464027
25fat-soluble vitamin biosynthetic process (GO:0042362)4.53473926
26regulation of glutamate receptor signaling pathway (GO:1900449)4.39450978
27ncRNA catabolic process (GO:0034661)4.38986675
28mRNA cleavage (GO:0006379)4.24875097
29RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)4.24138899
30regulation of cAMP-mediated signaling (GO:0043949)4.10583595
31signal peptide processing (GO:0006465)4.10455088
32regulation of translational elongation (GO:0006448)4.04529864
33regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.85554266
34glomerular visceral epithelial cell development (GO:0072015)3.83728186
35cellular response to alkaloid (GO:0071312)3.80015438
36vitamin biosynthetic process (GO:0009110)3.69950431
37ribonucleoprotein complex disassembly (GO:0032988)3.66182626
38viral mRNA export from host cell nucleus (GO:0046784)3.65481975
39negative regulation of adenylate cyclase activity (GO:0007194)3.59121251
40L-fucose metabolic process (GO:0042354)3.50809808
41L-fucose catabolic process (GO:0042355)3.50809808
42fucose catabolic process (GO:0019317)3.50809808
43negative regulation of glycoprotein metabolic process (GO:1903019)3.48079323
44negative regulation of cyclase activity (GO:0031280)3.44187001
45DNA deamination (GO:0045006)3.41836541
46N-terminal protein amino acid acetylation (GO:0006474)3.40263480
47preassembly of GPI anchor in ER membrane (GO:0016254)3.37547917
48glomerular epithelial cell development (GO:0072310)3.32502529
49negative regulation of lyase activity (GO:0051350)3.32319288
50coenzyme catabolic process (GO:0009109)3.29575690
51negative regulation of cell-matrix adhesion (GO:0001953)3.28780086
52signal complex assembly (GO:0007172)3.27897397
53cornea development in camera-type eye (GO:0061303)3.21600228
54nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.20785270
55fat-soluble vitamin catabolic process (GO:0042363)3.17932223
56vitamin catabolic process (GO:0009111)3.17932223
57regulation of cytokine production involved in inflammatory response (GO:1900015)3.16838093
58monoubiquitinated protein deubiquitination (GO:0035520)3.14682793
59positive regulation of fatty acid transport (GO:2000193)3.09122253
60pyrimidine dimer repair (GO:0006290)3.07852146
61positive regulation of icosanoid secretion (GO:0032305)3.05362361
62polyol biosynthetic process (GO:0046173)3.02066669
63glycosphingolipid metabolic process (GO:0006687)3.02038380
64thyroid hormone generation (GO:0006590)3.01843187
65neuronal action potential (GO:0019228)3.01512031
66regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.99862192
67regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)2.99554841
68negative regulation of exocytosis (GO:0045920)2.95441563
69regulation of female receptivity (GO:0045924)2.93504420
70regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.89000934
71omega-hydroxylase P450 pathway (GO:0097267)2.88359562
72aldehyde catabolic process (GO:0046185)2.87837289
73indolalkylamine metabolic process (GO:0006586)2.86717776
74water-soluble vitamin biosynthetic process (GO:0042364)2.86426936
75negative regulation of cAMP biosynthetic process (GO:0030818)2.85677620
76negative regulation of macrophage differentiation (GO:0045650)2.85399641
77thyroid hormone metabolic process (GO:0042403)2.81743839
78membrane depolarization during action potential (GO:0086010)2.80783925
79positive regulation of gluconeogenesis (GO:0045722)2.80083477
80quinone biosynthetic process (GO:1901663)2.79994697
81GPI anchor metabolic process (GO:0006505)2.79798930
82cellular response to ATP (GO:0071318)2.79793283
83glycolipid metabolic process (GO:0006664)2.78186880
84positive regulation of cardiac muscle cell differentiation (GO:2000727)2.78114006
85left/right axis specification (GO:0070986)2.77495831
86negative regulation of cyclic nucleotide biosynthetic process (GO:0030803)2.76772046
87regulation of calcium ion-dependent exocytosis (GO:0017158)2.74590050
88replication fork processing (GO:0031297)2.66910403
89detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.66405575
90membrane lipid metabolic process (GO:0006643)2.65819061
91wound healing, spreading of epidermal cells (GO:0035313)2.63871630
92negative regulation of nucleotide biosynthetic process (GO:0030809)2.63460440
93negative regulation of purine nucleotide biosynthetic process (GO:1900372)2.63460440
94response to caffeine (GO:0031000)2.63393671
95detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.62399866
96response to morphine (GO:0043278)2.61877233
97liposaccharide metabolic process (GO:1903509)2.61447983
98negative regulation of cytosolic calcium ion concentration (GO:0051481)13.7191151
99negative regulation of cAMP-mediated signaling (GO:0043951)10.8156873
100ether lipid metabolic process (GO:0046485)10.3193439

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_22108803_ChIP-Seq_LS180_Human3.56333175
2PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.30280057
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.22063355
4TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.85653055
5POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.85653055
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.79548821
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.74989427
8GBX2_23144817_ChIP-Seq_PC3_Human2.74020255
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.71785473
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.65128466
11PCGF2_27294783_Chip-Seq_ESCs_Mouse2.64629598
12ZNF274_21170338_ChIP-Seq_K562_Hela2.46083639
13BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.40492343
14BP1_19119308_ChIP-ChIP_Hs578T_Human2.38342803
15POU3F2_20337985_ChIP-ChIP_501MEL_Human2.31789852
16PCGF2_27294783_Chip-Seq_NPCs_Mouse2.20694824
17TAF15_26573619_Chip-Seq_HEK293_Human2.17295891
18RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.14056513
19RXR_22108803_ChIP-Seq_LS180_Human2.02692740
20SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.94252485
21CTBP2_25329375_ChIP-Seq_LNCAP_Human1.91729088
22SOX2_19829295_ChIP-Seq_ESCs_Human1.90166480
23NANOG_19829295_ChIP-Seq_ESCs_Human1.90166480
24SUZ12_27294783_Chip-Seq_NPCs_Mouse1.90150774
25FUS_26573619_Chip-Seq_HEK293_Human1.79871063
26IRF1_19129219_ChIP-ChIP_H3396_Human1.75438389
27NFE2_27457419_Chip-Seq_LIVER_Mouse1.74901852
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.73051993
29EGR1_19032775_ChIP-ChIP_M12_Human1.73021384
30TCF4_23295773_ChIP-Seq_U87_Human1.71897893
31CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.71043419
32CDX2_19796622_ChIP-Seq_MESCs_Mouse1.70535823
33EZH2_27294783_Chip-Seq_NPCs_Mouse1.69040048
34STAT3_23295773_ChIP-Seq_U87_Human1.65410937
35HTT_18923047_ChIP-ChIP_STHdh_Human1.65077604
36CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.62162627
37P300_19829295_ChIP-Seq_ESCs_Human1.61247928
38BCAT_22108803_ChIP-Seq_LS180_Human1.60381789
39EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.54953282
40SMAD3_21741376_ChIP-Seq_EPCs_Human1.50348399
41TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.48536863
42CBP_20019798_ChIP-Seq_JUKART_Human1.47044896
43IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.47044896
44FLI1_21867929_ChIP-Seq_TH2_Mouse1.44358201
45CRX_20693478_ChIP-Seq_RETINA_Mouse1.43773941
46IGF1R_20145208_ChIP-Seq_DFB_Human1.42481460
47GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40682364
48CDX2_22108803_ChIP-Seq_LS180_Human1.40571820
49MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.37298525
50AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.36979248
51ER_23166858_ChIP-Seq_MCF-7_Human1.35277764
52PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.34652146
53TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.30244764
54SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.28894461
55PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.27139263
56SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.25863880
57MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.25762709
58TP53_22573176_ChIP-Seq_HFKS_Human1.25162213
59CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.24968882
60TCF4_22108803_ChIP-Seq_LS180_Human1.23364096
61TP53_18474530_ChIP-ChIP_U2OS_Human1.22606330
62PRDM14_20953172_ChIP-Seq_ESCs_Human1.22550375
63EWS_26573619_Chip-Seq_HEK293_Human1.22459815
64AR_25329375_ChIP-Seq_VCAP_Human1.22407308
65OCT4_21477851_ChIP-Seq_ESCs_Mouse1.20492924
66UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20312713
67EGR1_23403033_ChIP-Seq_LIVER_Mouse1.19096397
68LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17815378
69SALL1_21062744_ChIP-ChIP_HESCs_Human1.17782374
70TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.17053303
71KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.16761030
72NANOG_20526341_ChIP-Seq_ESCs_Human1.16732175
73TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15430545
74SMAD4_21799915_ChIP-Seq_A2780_Human1.14017912
75VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.12107358
76TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10061301
77GATA3_21878914_ChIP-Seq_MCF-7_Human1.09019586
78P300_18555785_Chip-Seq_ESCs_Mouse1.08822863
79GABP_17652178_ChIP-ChIP_JURKAT_Human1.08049024
80MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.07768976
81EZH2_22144423_ChIP-Seq_EOC_Human1.07047573
82RUNX2_22187159_ChIP-Seq_PCA_Human1.07043114
83HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.06990816
84EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06907789
85OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06119833
86EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.06060520
87RNF2_27304074_Chip-Seq_NSC_Mouse1.05981352
88TP53_16413492_ChIP-PET_HCT116_Human1.05474508
89P53_22387025_ChIP-Seq_ESCs_Mouse1.04630726
90SOX2_21211035_ChIP-Seq_LN229_Gbm1.03938269
91SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.03605809
92TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03539594
93KLF5_20875108_ChIP-Seq_MESCs_Mouse1.03286134
94FOXH1_21741376_ChIP-Seq_ESCs_Human1.02560423
95NANOG_18555785_Chip-Seq_ESCs_Mouse1.02477351
96AR_21572438_ChIP-Seq_LNCaP_Human1.01135198
97CTCF_18555785_Chip-Seq_ESCs_Mouse1.00213373
98STAT3_18555785_Chip-Seq_ESCs_Mouse0.99380165
99AR_20517297_ChIP-Seq_VCAP_Human0.99151956
100MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98361040

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009278_abnormal_bone_marrow5.72783341
2MP0009780_abnormal_chondrocyte_physiolo5.40552520
3MP0002876_abnormal_thyroid_physiology5.07264114
4MP0005360_urolithiasis4.83579577
5MP0001968_abnormal_touch/_nociception3.81668432
6MP0005503_abnormal_tendon_morphology3.14176602
7MP0001501_abnormal_sleep_pattern3.12680588
8MP0003880_abnormal_central_pattern3.08899849
9MP0009764_decreased_sensitivity_to3.03141270
10MP0003941_abnormal_skin_development2.82246636
11MP0005646_abnormal_pituitary_gland2.69605609
12MP0003195_calcinosis2.59353613
13MP0006035_abnormal_mitochondrial_morpho2.30889665
14MP0003045_fibrosis2.28453967
15MP0000569_abnormal_digit_pigmentation2.23752543
16MP0001664_abnormal_digestion2.22470244
17MP0000678_abnormal_parathyroid_gland2.16942643
18MP0005551_abnormal_eye_electrophysiolog2.08127882
19MP0001545_abnormal_hematopoietic_system2.01990677
20MP0005397_hematopoietic_system_phenotyp2.01990677
21MP0003646_muscle_fatigue2.01533261
22MP0004147_increased_porphyrin_level2.00345736
23MP0000566_synostosis1.96058246
24MP0005645_abnormal_hypothalamus_physiol1.85760672
25MP0002249_abnormal_larynx_morphology1.73810434
26MP0000681_abnormal_thyroid_gland1.73607084
27MP0009046_muscle_twitch1.62197362
28MP0003633_abnormal_nervous_system1.54009058
29MP0003183_abnormal_peptide_metabolism1.51515430
30MP0006054_spinal_hemorrhage1.47689657
31MP0002733_abnormal_thermal_nociception1.47324135
32MP0002168_other_aberrant_phenotype1.39928493
33MP0009745_abnormal_behavioral_response1.36769663
34MP0010234_abnormal_vibrissa_follicle1.34718487
35MP0009333_abnormal_splenocyte_physiolog1.33915275
36MP0000015_abnormal_ear_pigmentation1.32759070
37MP0002272_abnormal_nervous_system1.30559552
38MP0003959_abnormal_lean_body1.26093587
39MP0003567_abnormal_fetal_cardiomyocyte1.22793484
40MP0004782_abnormal_surfactant_physiolog1.17280908
41MP0003638_abnormal_response/metabolism_1.15589020
42MP0008872_abnormal_physiological_respon1.12377312
43MP0005408_hypopigmentation1.11294152
44MP0002796_impaired_skin_barrier1.09964304
45MP0005075_abnormal_melanosome_morpholog1.09221516
46MP0001486_abnormal_startle_reflex1.08865209
47MP0001324_abnormal_eye_pigmentation1.07849788
48MP0009053_abnormal_anal_canal1.07011542
49MP0003937_abnormal_limbs/digits/tail_de1.06714120
50MP0009765_abnormal_xenobiotic_induced1.06166367
51MP0008058_abnormal_DNA_repair1.05678176
52MP0003191_abnormal_cellular_cholesterol1.04355973
53MP0000230_abnormal_systemic_arterial0.97651425
54MP0001970_abnormal_pain_threshold0.96690062
55MP0002148_abnormal_hypersensitivity_rea0.96588766
56MP0003950_abnormal_plasma_membrane0.96293862
57MP0005310_abnormal_salivary_gland0.94793463
58MP0001919_abnormal_reproductive_system0.92652539
59MP0006072_abnormal_retinal_apoptosis0.90856011
60MP0000049_abnormal_middle_ear0.90594100
61MP0002693_abnormal_pancreas_physiology0.89912034
62MP0003631_nervous_system_phenotype0.87720926
63MP0003868_abnormal_feces_composition0.87186445
64MP0008875_abnormal_xenobiotic_pharmacok0.85146750
65MP0002971_abnormal_brown_adipose0.77381200
66MP0005395_other_phenotype0.76467066
67MP0001881_abnormal_mammary_gland0.75431626
68MP0003879_abnormal_hair_cell0.71055414
69MP0008057_abnormal_DNA_replication0.69797613
70MP0002095_abnormal_skin_pigmentation0.65829710
71MP0002557_abnormal_social/conspecific_i0.65041764
72MP0001529_abnormal_vocalization0.65018833
73MP0000358_abnormal_cell_content/0.64808018
74MP0005195_abnormal_posterior_eye0.63682346
75MP0005334_abnormal_fat_pad0.63321028
76MP0008789_abnormal_olfactory_epithelium0.62500157
77MP0005085_abnormal_gallbladder_physiolo0.62251623
78MP0000685_abnormal_immune_system0.61677664
79MP0005083_abnormal_biliary_tract0.60999578
80MP0008775_abnormal_heart_ventricle0.60883318
81MP0002736_abnormal_nociception_after0.57911806
82MP0006036_abnormal_mitochondrial_physio0.56513829
83MP0004085_abnormal_heartbeat0.56351184
84MP0000749_muscle_degeneration0.56113242
85MP0002229_neurodegeneration0.55375644
86MP0005197_abnormal_uvea_morphology0.54483352
87MP0002063_abnormal_learning/memory/cond0.53964667
88MP0002932_abnormal_joint_morphology0.53202248
89MP0004858_abnormal_nervous_system0.52177438
90MP0006276_abnormal_autonomic_nervous0.51739721
91MP0005174_abnormal_tail_pigmentation0.50594193
92MP0001765_abnormal_ion_homeostasis0.49690430
93MP0005167_abnormal_blood-brain_barrier0.48598528
94MP0001756_abnormal_urination0.47952399
95MP0005636_abnormal_mineral_homeostasis0.47826660
96MP0002064_seizures0.47363480
97MP0010771_integument_phenotype0.44871247
98MP0002572_abnormal_emotion/affect_behav0.44717957
99MP0002752_abnormal_somatic_nervous0.44488841
100MP0005464_abnormal_platelet_physiology0.44373019

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)6.28483145
2Intestinal atresia (HP:0011100)6.08816074
3Pancreatic islet-cell hyperplasia (HP:0004510)5.61459426
4Abnormality of the aortic arch (HP:0012303)5.47641095
5Broad alveolar ridges (HP:0000187)5.00248575
6Poor head control (HP:0002421)4.48276664
7Large for gestational age (HP:0001520)4.47232357
8Thickened helices (HP:0000391)4.25623835
9Mesangial abnormality (HP:0001966)4.22128674
10Focal motor seizures (HP:0011153)4.12177305
11Abnormality of endocrine pancreas physiology (HP:0012093)3.98747729
12Abnormality of the pancreatic islet cells (HP:0006476)3.98747729
13Oligodontia (HP:0000677)3.73080026
14Agitation (HP:0000713)3.67445532
15Gaze-evoked nystagmus (HP:0000640)3.56908955
16Congenital ichthyosiform erythroderma (HP:0007431)3.32787952
17Abnormality of the ileum (HP:0001549)3.25687790
18Hypoproteinemia (HP:0003075)3.21934488
19Tubular atrophy (HP:0000092)3.19039672
20Neonatal respiratory distress (HP:0002643)3.13130481
21Type II lissencephaly (HP:0007260)2.92662666
22Gastrointestinal atresia (HP:0002589)2.91639836
23Elevated erythrocyte sedimentation rate (HP:0003565)2.87276049
24Large eyes (HP:0001090)2.85146666
25Abnormality of the columella (HP:0009929)2.84444703
26Cerebellar dysplasia (HP:0007033)2.72595604
27Progressive inability to walk (HP:0002505)2.72340633
28Ectropion (HP:0000656)2.62411313
29Abnormality of macular pigmentation (HP:0008002)2.60901597
30Abnormality of the alveolar ridges (HP:0006477)2.56546113
31Abolished electroretinogram (ERG) (HP:0000550)2.56331562
32Chromosomal breakage induced by crosslinking agents (HP:0003221)2.55743433
33Focal seizures (HP:0007359)2.55583054
34High anterior hairline (HP:0009890)2.43690723
35Keratoconus (HP:0000563)2.42544042
36Increased corneal curvature (HP:0100692)2.42544042
37Myositis (HP:0100614)2.41647224
38Attenuation of retinal blood vessels (HP:0007843)2.38646089
39Hyperpituitarism (HP:0010514)2.38295034
40Tented upper lip vermilion (HP:0010804)2.36810801
41Optic nerve hypoplasia (HP:0000609)2.32569978
423-Methylglutaconic aciduria (HP:0003535)2.28185151
43Central scotoma (HP:0000603)2.27407396
44Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.25807651
45Abnormality of B cell number (HP:0010975)2.22202726
46Long nose (HP:0003189)2.20559538
47Scotoma (HP:0000575)2.20553357
48Orchitis (HP:0100796)2.20281189
49Pendular nystagmus (HP:0012043)2.19163034
50Lissencephaly (HP:0001339)2.18822964
51Autoimmune hemolytic anemia (HP:0001890)2.16808963
52Congenital stationary night blindness (HP:0007642)2.14275003
53Restlessness (HP:0000711)2.13644061
54Broad-based gait (HP:0002136)2.09327532
55Aplasia/Hypoplasia of the brainstem (HP:0007362)2.06746649
56Hypoplasia of the brainstem (HP:0002365)2.06746649
57Chromsome breakage (HP:0040012)2.06297729
58Non-midline cleft lip (HP:0100335)2.06217883
59Dialeptic seizures (HP:0011146)2.04385411
60Poor speech (HP:0002465)2.01097699
61Thyroid-stimulating hormone excess (HP:0002925)11.6877380
62Hypoplasia of the pons (HP:0012110)1.96831675
63Supernumerary spleens (HP:0009799)1.95738814
64Methylmalonic aciduria (HP:0012120)1.94943703
65Abnormality of midbrain morphology (HP:0002418)1.90477134
66Molar tooth sign on MRI (HP:0002419)1.90477134
67Pancreatic cysts (HP:0001737)1.90212341
68Inability to walk (HP:0002540)1.89696963
69Ileus (HP:0002595)1.83059553
70Neoplasm of the lung (HP:0100526)1.82489902
71Dysdiadochokinesis (HP:0002075)1.82058681
72Generalized tonic-clonic seizures (HP:0002069)1.81464931
73Nephroblastoma (Wilms tumor) (HP:0002667)1.80294228
74Severe visual impairment (HP:0001141)1.80145028
75Facial diplegia (HP:0001349)1.79106512
76Hypothermia (HP:0002045)1.78908734
77Aplasia/Hypoplasia of the spleen (HP:0010451)1.78638677
78Median cleft lip (HP:0000161)1.78330198
79Hyperglycinuria (HP:0003108)1.78189654
80Nonprogressive disorder (HP:0003680)1.77981529
81Postaxial foot polydactyly (HP:0001830)1.75925135
82Neoplasm of the respiratory system (HP:0100606)1.75470111
83Abnormality of the pons (HP:0007361)1.75081499
84Decreased electroretinogram (ERG) amplitude (HP:0000654)1.73995741
85Arthropathy (HP:0003040)1.72909102
86B lymphocytopenia (HP:0010976)1.72486861
87Asplenia (HP:0001746)1.70655567
88Pancreatic fibrosis (HP:0100732)1.70232122
89Embryonal renal neoplasm (HP:0011794)1.68162487
90Depressed nasal tip (HP:0000437)1.68150649
91Decreased circulating renin level (HP:0003351)1.68011848
92Muscular dystrophy (HP:0003560)1.67559389
93Testicular neoplasm (HP:0010788)1.66277142
94Goiter (HP:0000853)1.65145132
95Ketoacidosis (HP:0001993)1.63285792
96Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.61675311
97Hamartoma (HP:0010566)1.61496836
98Abnormal albumin level (HP:0012116)1.60881801
99Hypoalbuminemia (HP:0003073)1.60881801
100Hyperventilation (HP:0002883)1.60350571

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ADRBK29.45809907
2FRK5.10075446
3ERN13.44495664
4PINK12.83241829
5MAP4K22.82230344
6ADRBK12.58852805
7IRAK32.01909156
8CSNK1G12.00427873
9GRK71.97620815
10CSNK1G31.95221069
11ACVR1B1.83777444
12PRKCE1.79806340
13CSNK1A1L1.79716261
14FES1.70144491
15PRKCG1.68867916
16PNCK1.65328829
17GRK11.63727505
18IRAK11.59207753
19TGFBR11.52724313
20CSNK1G21.51608557
21WNK31.43379363
22BMPR1B1.30416431
23NUAK11.28141648
24MAPK111.25978331
25PLK21.23886989
26DYRK31.22745451
27MKNK11.21755583
28FER1.21404918
29TYRO31.12717121
30TAOK31.08316470
31MKNK21.03023252
32MAP3K91.02982530
33GRK51.01151131
34OXSR10.99401373
35PRKCI0.97370185
36NEK10.96411961
37FLT30.95811647
38TEC0.91591745
39EIF2AK30.91397508
40MARK10.90863062
41STK380.90435494
42TNIK0.84873747
43CLK10.84602381
44TESK10.82687343
45TIE10.81985029
46ZAK0.78616609
47CAMK2A0.72629068
48MST40.72106626
49CAMK10.69250156
50MAPK130.61467887
51CSNK1A10.60163939
52DYRK1A0.57876583
53MATK0.56564532
54ERBB20.49444286
55BCR0.48358749
56BMPR20.47296240
57PRKCA0.45409716
58STK390.43857842
59PTK2B0.42948396
60CAMK1G0.42758462
61NEK90.40416487
62MAPKAPK50.40006418
63ITK0.39416457
64ATR0.38971473
65CSNK1E0.38133128
66PRKCB0.38114454
67INSRR0.37991278
68KIT0.36211482
69CASK0.36202400
70STK30.33829000
71MAPKAPK30.33377122
72TRIM280.30670194
73VRK10.30586734
74PRKACA0.29549227
75NME10.29507662
76IKBKB0.27922350
77MOS0.26381745
78CAMK40.25616020
79PRKACG0.25406792
80WNK40.24543481
81BTK0.23682003
82TAF10.23389680
83CSNK1D0.23374620
84BRAF0.22021400
85ABL10.20954464
86MAPK10.20745359
87IKBKE0.19584513
88PAK30.19138749
89PLK30.18754235
90VRK20.18380436
91PRKG10.18231930
92DAPK20.18167606
93SGK10.17716371
94TNK20.17290437
95RPS6KA30.15953642
96CSF1R0.15149250
97MAP3K120.15142334
98PHKG20.14471766
99PHKG10.14471766
100DAPK10.13675776

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.29225565
2Dorso-ventral axis formation_Homo sapiens_hsa043203.21082186
3Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.86815061
4Steroid hormone biosynthesis_Homo sapiens_hsa001402.75505346
5Olfactory transduction_Homo sapiens_hsa047402.73075560
6Phototransduction_Homo sapiens_hsa047442.61197723
7Cyanoamino acid metabolism_Homo sapiens_hsa004602.58523403
8Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.40291786
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.20696675
10Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.11396061
11Nitrogen metabolism_Homo sapiens_hsa009102.08879387
12Morphine addiction_Homo sapiens_hsa050322.07746834
13Linoleic acid metabolism_Homo sapiens_hsa005912.03482314
14Tryptophan metabolism_Homo sapiens_hsa003801.98023748
15Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.92689035
16ABC transporters_Homo sapiens_hsa020101.88145898
17Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.85311674
18Protein export_Homo sapiens_hsa030601.83915965
19Butanoate metabolism_Homo sapiens_hsa006501.76320104
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.74651114
21Caffeine metabolism_Homo sapiens_hsa002321.70402088
22Fanconi anemia pathway_Homo sapiens_hsa034601.70051160
23Sphingolipid metabolism_Homo sapiens_hsa006001.62858344
24Basal transcription factors_Homo sapiens_hsa030221.61930547
25Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.56953388
26Glycerolipid metabolism_Homo sapiens_hsa005611.53343049
27Arachidonic acid metabolism_Homo sapiens_hsa005901.52583992
28Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.49351296
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.41596846
30Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.36243590
31Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.34026346
32Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.30986727
33Starch and sucrose metabolism_Homo sapiens_hsa005001.30977769
34Taste transduction_Homo sapiens_hsa047421.29611120
35Intestinal immune network for IgA production_Homo sapiens_hsa046721.23814498
36Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.22682898
37Proteasome_Homo sapiens_hsa030501.22191214
38Ovarian steroidogenesis_Homo sapiens_hsa049131.21562158
39Pentose phosphate pathway_Homo sapiens_hsa000301.18050088
40Retinol metabolism_Homo sapiens_hsa008301.15456826
41Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.12299191
42Chemical carcinogenesis_Homo sapiens_hsa052041.11395667
43Glycosaminoglycan degradation_Homo sapiens_hsa005311.09039544
44Primary immunodeficiency_Homo sapiens_hsa053401.07399407
45Pentose and glucuronate interconversions_Homo sapiens_hsa000401.05377810
46Ether lipid metabolism_Homo sapiens_hsa005651.05153809
47Fatty acid degradation_Homo sapiens_hsa000711.04767391
48Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.04387942
49Complement and coagulation cascades_Homo sapiens_hsa046101.02766670
50Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.96569642
51Sulfur relay system_Homo sapiens_hsa041220.95826356
52RNA degradation_Homo sapiens_hsa030180.90837026
53Mineral absorption_Homo sapiens_hsa049780.89047242
54Parkinsons disease_Homo sapiens_hsa050120.83880746
55Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.81908240
56Salivary secretion_Homo sapiens_hsa049700.78394567
57Hedgehog signaling pathway_Homo sapiens_hsa043400.77676080
58Peroxisome_Homo sapiens_hsa041460.77587640
59Legionellosis_Homo sapiens_hsa051340.74345151
60Purine metabolism_Homo sapiens_hsa002300.74310661
61Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.72650164
62Drug metabolism - other enzymes_Homo sapiens_hsa009830.69594010
63Primary bile acid biosynthesis_Homo sapiens_hsa001200.68326140
64Metabolic pathways_Homo sapiens_hsa011000.68124159
65Histidine metabolism_Homo sapiens_hsa003400.67132412
66Circadian entrainment_Homo sapiens_hsa047130.66307011
67Propanoate metabolism_Homo sapiens_hsa006400.65386956
68RNA transport_Homo sapiens_hsa030130.64510425
69Oxidative phosphorylation_Homo sapiens_hsa001900.63075213
70Cysteine and methionine metabolism_Homo sapiens_hsa002700.61583581
71Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.60915312
72Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.60335494
73RNA polymerase_Homo sapiens_hsa030200.60269674
74Alzheimers disease_Homo sapiens_hsa050100.59645481
75One carbon pool by folate_Homo sapiens_hsa006700.59140697
76Graft-versus-host disease_Homo sapiens_hsa053320.56219926
77Serotonergic synapse_Homo sapiens_hsa047260.55738284
78Regulation of autophagy_Homo sapiens_hsa041400.54413928
79Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.54223246
80GABAergic synapse_Homo sapiens_hsa047270.54020766
81Asthma_Homo sapiens_hsa053100.47755189
82SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45799996
83Homologous recombination_Homo sapiens_hsa034400.44511795
84Long-term depression_Homo sapiens_hsa047300.44423336
85NOD-like receptor signaling pathway_Homo sapiens_hsa046210.44223783
86Calcium signaling pathway_Homo sapiens_hsa040200.43593652
87Non-homologous end-joining_Homo sapiens_hsa034500.43089971
88Maturity onset diabetes of the young_Homo sapiens_hsa049500.43072455
89Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41475442
90Basal cell carcinoma_Homo sapiens_hsa052170.41239194
91Nicotine addiction_Homo sapiens_hsa050330.39626270
92mRNA surveillance pathway_Homo sapiens_hsa030150.39269870
93Glutamatergic synapse_Homo sapiens_hsa047240.38166771
94Huntingtons disease_Homo sapiens_hsa050160.37424807
95Arginine biosynthesis_Homo sapiens_hsa002200.37017216
96Allograft rejection_Homo sapiens_hsa053300.36701394
97Glutathione metabolism_Homo sapiens_hsa004800.36262718
98Selenocompound metabolism_Homo sapiens_hsa004500.36224676
99Type I diabetes mellitus_Homo sapiens_hsa049400.34055397
100Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.33344798

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