VPS28

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein subunit of the ESCRT-I complex (endosomal complexes required for transport), which functions in the transport and sorting of proteins into subcellular vesicles. This complex can also be hijacked to facilitate the budding of enveloped viruses from the cell membrane. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sequestering of actin monomers (GO:0042989)4.13079907
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.46914448
3antigen processing and presentation of endogenous antigen (GO:0019883)3.41356170
4negative regulation of cell killing (GO:0031342)3.35917481
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.35917481
6ATP synthesis coupled proton transport (GO:0015986)3.32570306
7energy coupled proton transport, down electrochemical gradient (GO:0015985)3.32570306
8mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.22612439
9antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.10017030
10neutrophil activation involved in immune response (GO:0002283)3.08449219
11energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.05086788
12ATP hydrolysis coupled proton transport (GO:0015991)3.05086788
13electron transport chain (GO:0022900)2.97829432
14respiratory electron transport chain (GO:0022904)2.97092441
15mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.91056872
16phagosome maturation (GO:0090382)2.89776550
17* viral protein processing (GO:0019082)2.89497892
18GDP-mannose metabolic process (GO:0019673)2.81789312
19response to interferon-beta (GO:0035456)2.79119923
20regulation of autophagic vacuole assembly (GO:2000785)2.78264412
21viral transcription (GO:0019083)2.77239243
22antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.74475908
23autophagic vacuole fusion (GO:0000046)2.74397866
24protein complex biogenesis (GO:0070271)2.68686677
25regulation of vacuole organization (GO:0044088)2.60279225
26amino sugar catabolic process (GO:0046348)2.57750949
27negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.55977231
28cellular response to interferon-beta (GO:0035458)2.55632843
29immunoglobulin mediated immune response (GO:0016064)2.54775533
30hydrogen ion transmembrane transport (GO:1902600)2.52662935
31platelet dense granule organization (GO:0060155)2.51108054
32purine deoxyribonucleotide catabolic process (GO:0009155)2.49188468
33Arp2/3 complex-mediated actin nucleation (GO:0034314)2.48677427
34metallo-sulfur cluster assembly (GO:0031163)2.48283985
35iron-sulfur cluster assembly (GO:0016226)2.48283985
36base-excision repair, AP site formation (GO:0006285)2.45807677
37regulation of mast cell degranulation (GO:0043304)2.40219337
38deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.39158586
39mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.36553490
40mitochondrial respiratory chain complex I assembly (GO:0032981)2.36553490
41NADH dehydrogenase complex assembly (GO:0010257)2.36553490
42neutrophil activation (GO:0042119)2.33133598
43detection of bacterium (GO:0016045)2.32266400
44translational termination (GO:0006415)2.32255868
45regulation of respiratory burst (GO:0060263)2.32083273
46proton transport (GO:0015992)2.31055447
47regulation of hydrogen peroxide metabolic process (GO:0010310)2.29507912
48positive regulation of mast cell activation (GO:0033005)2.29008214
49hydrogen transport (GO:0006818)2.28704110
50glutathione biosynthetic process (GO:0006750)2.28336011
51negative regulation of innate immune response (GO:0045824)2.27040128
52lipoxygenase pathway (GO:0019372)2.26000783
53negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.25369003
54nonribosomal peptide biosynthetic process (GO:0019184)2.24733126
55amyloid precursor protein catabolic process (GO:0042987)2.23260831
56regulation of mast cell activation (GO:0033003)2.22808628
57negative regulation of B cell apoptotic process (GO:0002903)2.21685506
58translational elongation (GO:0006414)2.21429429
59actin filament polymerization (GO:0030041)2.20117280
60protein insertion into membrane (GO:0051205)2.19880743
61positive regulation of gamma-delta T cell activation (GO:0046645)2.19369353
62ATP biosynthetic process (GO:0006754)2.18943133
63arginine catabolic process (GO:0006527)2.18740908
64negative regulation of tumor necrosis factor production (GO:0032720)2.17695025
65cellular biogenic amine catabolic process (GO:0042402)2.17162969
66amine catabolic process (GO:0009310)2.17162969
67phosphatidylglycerol biosynthetic process (GO:0006655)2.16851534
68positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.16635533
69positive regulation of antigen processing and presentation (GO:0002579)2.16461954
70mitochondrial respiratory chain complex assembly (GO:0033108)2.15323957
71* virion assembly (GO:0019068)2.14858811
72neurotransmitter catabolic process (GO:0042135)2.13651951
73granulocyte activation (GO:0036230)2.13390057
74negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)2.13093490
75hydrogen peroxide biosynthetic process (GO:0050665)2.12098110
76regulation of mast cell activation involved in immune response (GO:0033006)2.10788266
77regulation of regulatory T cell differentiation (GO:0045589)2.09654905
78positive thymic T cell selection (GO:0045059)2.09177489
79leukocyte aggregation (GO:0070486)2.08975415
80purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.08784418
81* viral life cycle (GO:0019058)2.08753113
82response to peptidoglycan (GO:0032494)2.08453397
83actin nucleation (GO:0045010)2.08304563
84protein localization to endoplasmic reticulum (GO:0070972)2.07750059
85positive regulation of mast cell activation involved in immune response (GO:0033008)2.07151098
86positive regulation of mast cell degranulation (GO:0043306)2.07151098
87detection of other organism (GO:0098543)2.06404169
88purinergic nucleotide receptor signaling pathway (GO:0035590)2.06250070
89protein targeting to ER (GO:0045047)2.04260806
90SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.04243172
91regulation of myeloid leukocyte mediated immunity (GO:0002886)2.03779810
92deoxyribonucleotide catabolic process (GO:0009264)2.02792063
93purine nucleoside triphosphate biosynthetic process (GO:0009145)2.02617273
94positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.02098449
95establishment of mitochondrion localization (GO:0051654)2.01316477
96cotranslational protein targeting to membrane (GO:0006613)2.00658781
97reactive oxygen species biosynthetic process (GO:1903409)2.00228057
98synaptic vesicle exocytosis (GO:0016079)1.99684900
99NIK/NF-kappaB signaling (GO:0038061)1.99574744
100transferrin transport (GO:0033572)1.98673340

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.95741618
2THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.80560888
3* LXR_22292898_ChIP-Seq_THP-1_Human2.42532111
4CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.40235005
5IRF8_22096565_ChIP-ChIP_GC-B_Human2.26150250
6IKZF1_21737484_ChIP-ChIP_HCT116_Human2.24602615
7RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.20424445
8* BCL6_27268052_Chip-Seq_Bcells_Human2.18362558
9* VDR_21846776_ChIP-Seq_THP-1_Human2.13823745
10SRY_22984422_ChIP-ChIP_TESTIS_Rat2.11025268
11EZH2_22144423_ChIP-Seq_EOC_Human2.05783204
12ELF1_17652178_ChIP-ChIP_JURKAT_Human2.01245292
13CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.93683865
14ELF1_20517297_ChIP-Seq_JURKAT_Human1.91636738
15* TET1_21451524_ChIP-Seq_MESCs_Mouse1.90138677
16* P68_20966046_ChIP-Seq_HELA_Human1.88482750
17* BCOR_27268052_Chip-Seq_Bcells_Human1.84344263
18LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.80110438
19MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.75221085
20TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.73967875
21BP1_19119308_ChIP-ChIP_Hs578T_Human1.71311100
22MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.70812498
23SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.70085270
24SA1_27219007_Chip-Seq_ERYTHROID_Human1.68333337
25NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.59917194
26DNAJC2_21179169_ChIP-ChIP_NT2_Human1.59180254
27FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.57904095
28EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.57142977
29KDM2B_26808549_Chip-Seq_SUP-B15_Human1.56555477
30CTCF_26484167_Chip-Seq_Bcells_Mouse1.55203777
31SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.55065648
32PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.54531520
33YY1_22570637_ChIP-Seq_MALME-3M_Human1.52329672
34SA1_27219007_Chip-Seq_Bcells_Human1.52192000
35ELK3_25401928_ChIP-Seq_HUVEC_Human1.51603423
36SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.50547488
37* E2F1_20622854_ChIP-Seq_HELA_Human1.49834004
38E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.49420482
39SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.49120313
40LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.47324918
41CTCF_27219007_Chip-Seq_Bcells_Human1.46818353
42E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.46263265
43GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.45501703
44RARG_19884340_ChIP-ChIP_MEFs_Mouse1.45144609
45CTCF_20526341_ChIP-Seq_ESCs_Human1.42866508
46* PHF8_20622854_ChIP-Seq_HELA_Human1.42167988
47VDR_24763502_ChIP-Seq_THP-1_Human1.41934917
48CTCF_27219007_Chip-Seq_ERYTHROID_Human1.39513343
49ERG_21242973_ChIP-ChIP_JURKAT_Human1.37237098
50MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.36470023
51* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.35334668
52NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.34139724
53STAT6_21828071_ChIP-Seq_BEAS2B_Human1.33750009
54PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.33311142
55RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.32052033
56KDM2B_26808549_Chip-Seq_DND41_Human1.30572330
57CTCF_18555785_ChIP-Seq_MESCs_Mouse1.28651011
58MAF_26560356_Chip-Seq_TH2_Human1.27179762
59SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.26821169
60UTX_26944678_Chip-Seq_JUKART_Human1.25535036
61* P300_27268052_Chip-Seq_Bcells_Human1.25449986
62IRF8_21731497_ChIP-ChIP_J774_Mouse1.22407247
63* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.21366942
64SMC4_20622854_ChIP-Seq_HELA_Human1.21326588
65RACK7_27058665_Chip-Seq_MCF-7_Human1.20831233
66* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20808474
67* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.20498609
68RUNX1_22412390_ChIP-Seq_EML_Mouse1.19941111
69STAT1_20625510_ChIP-Seq_HELA_Human1.19315662
70SUZ12_27294783_Chip-Seq_ESCs_Mouse1.17312409
71* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15583495
72RARB_24833708_ChIP-Seq_LIVER_Mouse1.15344377
73ERA_21632823_ChIP-Seq_H3396_Human1.14080729
74* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.12631202
75GATA1_19941827_ChIP-Seq_MEL_Mouse1.12573238
76IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.12019089
77DROSHA_22980978_ChIP-Seq_HELA_Human1.11462951
78MAF_26560356_Chip-Seq_TH1_Human1.11128736
79CTCF_21964334_ChIP-Seq_BJAB-B_Human1.10159222
80RAD21_21589869_ChIP-Seq_MESCs_Mouse1.08818798
81BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.06747202
82SPI1_23127762_ChIP-Seq_K562_Human1.06482294
83EZH2_27294783_Chip-Seq_ESCs_Mouse1.06409938
84SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.06216210
85FOXP1_21924763_ChIP-Seq_HESCs_Human1.04724490
86TP63_22573176_ChIP-Seq_HFKS_Human1.03953330
87PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03853598
88OCT4_19829295_ChIP-Seq_ESCs_Human1.03277309
89KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.02775288
90CTCF_21964334_Chip-Seq_Bcells_Human1.00231568
91* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99629566
92SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.98725940
93REST_18959480_ChIP-ChIP_MESCs_Mouse0.98420801
94SPI1_23547873_ChIP-Seq_NB4_Human0.98002432
95CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.96011994
96SRF_21415370_ChIP-Seq_HL-1_Mouse0.95954577
97YY1_21170310_ChIP-Seq_MESCs_Mouse0.95085453
98SPI1_20517297_ChIP-Seq_HL60_Human0.94948931
99* PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.94832741
100* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93414195

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to2.83760420
2MP0003436_decreased_susceptibility_to2.69420944
3MP0005058_abnormal_lysosome_morphology2.56091993
4MP0002653_abnormal_ependyma_morphology2.29836207
5MP0005671_abnormal_response_to2.19072847
6MP0001835_abnormal_antigen_presentation2.12180996
7MP0003011_delayed_dark_adaptation2.05523569
8MP0005464_abnormal_platelet_physiology1.94915998
9MP0005025_abnormal_response_to1.92874776
10MP0003172_abnormal_lysosome_physiology1.89847411
11MP0002148_abnormal_hypersensitivity_rea1.89431710
12MP0009840_abnormal_foam_cell1.85416812
13MP0002822_catalepsy1.72819692
14MP0009785_altered_susceptibility_to1.72538017
15MP0001790_abnormal_immune_system1.69507202
16MP0005387_immune_system_phenotype1.69507202
17MP0002419_abnormal_innate_immunity1.65560748
18MP0001905_abnormal_dopamine_level1.63302762
19MP0005000_abnormal_immune_tolerance1.63236751
20MP0000685_abnormal_immune_system1.60488501
21MP0003303_peritoneal_inflammation1.57541882
22MP0002723_abnormal_immune_serum1.53532990
23MP0001968_abnormal_touch/_nociception1.52814725
24MP0003806_abnormal_nucleotide_metabolis1.52698267
25MP0001800_abnormal_humoral_immune1.49805110
26MP0000465_gastrointestinal_hemorrhage1.47988402
27MP0009379_abnormal_foot_pigmentation1.45008922
28MP0005083_abnormal_biliary_tract1.40928439
29MP0001533_abnormal_skeleton_physiology1.40367517
30MP0009764_decreased_sensitivity_to1.40217914
31MP0006082_CNS_inflammation1.38980405
32MP0003866_abnormal_defecation1.37072976
33MP0008260_abnormal_autophagy1.37002191
34MP0002420_abnormal_adaptive_immunity1.36905740
35MP0002452_abnormal_antigen_presenting1.36658685
36MP0001819_abnormal_immune_cell1.35986237
37MP0004859_abnormal_synaptic_plasticity1.35183175
38MP0009333_abnormal_splenocyte_physiolog1.33286575
39MP0003879_abnormal_hair_cell1.32165207
40MP0005075_abnormal_melanosome_morpholog1.31287517
41MP0003191_abnormal_cellular_cholesterol1.30738694
42MP0000604_amyloidosis1.30573058
43MP0010155_abnormal_intestine_physiology1.28914802
44MP0001970_abnormal_pain_threshold1.27226002
45MP0000343_altered_response_to1.26483409
46MP0001986_abnormal_taste_sensitivity1.25213966
47MP0004142_abnormal_muscle_tone1.24617247
48MP0003075_altered_response_to1.24337826
49MP0003787_abnormal_imprinting1.23371939
50MP0001663_abnormal_digestive_system1.22300880
51MP0001845_abnormal_inflammatory_respons1.22180456
52MP0004858_abnormal_nervous_system1.14044730
53MP0001873_stomach_inflammation1.13734936
54MP0002277_abnormal_respiratory_mucosa1.13089925
55MP0002132_abnormal_respiratory_system1.13007644
56MP0002733_abnormal_thermal_nociception1.12682611
57MP0003329_amyloid_beta_deposits1.11425077
58MP0002933_joint_inflammation1.10208937
59MP0009278_abnormal_bone_marrow1.07137941
60MP0002736_abnormal_nociception_after1.05495976
61MP0006276_abnormal_autonomic_nervous1.04658335
62MP0008875_abnormal_xenobiotic_pharmacok1.03563248
63MP0008469_abnormal_protein_level1.01829538
64MP0006036_abnormal_mitochondrial_physio1.01152481
65MP0005535_abnormal_body_temperature1.01051945
66MP0004510_myositis1.00826533
67MP0009745_abnormal_behavioral_response1.00403353
68MP0005365_abnormal_bile_salt0.99222407
69MP0008872_abnormal_physiological_respon0.98281135
70MP0002064_seizures0.95601661
71MP0003880_abnormal_central_pattern0.94206624
72MP0002138_abnormal_hepatobiliary_system0.93645966
73MP0005084_abnormal_gallbladder_morpholo0.93052250
74MP0005166_decreased_susceptibility_to0.92366194
75MP0000716_abnormal_immune_system0.91809362
76MP0004381_abnormal_hair_follicle0.91396259
77MP0002572_abnormal_emotion/affect_behav0.90808820
78MP0002405_respiratory_system_inflammati0.90776120
79MP0001764_abnormal_homeostasis0.90137972
80MP0005381_digestive/alimentary_phenotyp0.89996079
81MP0003635_abnormal_synaptic_transmissio0.88942023
82MP0002272_abnormal_nervous_system0.88880555
83MP0005167_abnormal_blood-brain_barrier0.88866131
84MP0003183_abnormal_peptide_metabolism0.88244804
85MP0003186_abnormal_redox_activity0.87808432
86MP0003638_abnormal_response/metabolism_0.86823273
87MP0005423_abnormal_somatic_nervous0.86735645
88MP0000015_abnormal_ear_pigmentation0.85145627
89MP0008874_decreased_physiological_sensi0.81404515
90MP0002876_abnormal_thyroid_physiology0.80672169
91MP0002063_abnormal_learning/memory/cond0.79360279
92MP0005360_urolithiasis0.79281034
93MP0002837_dystrophic_cardiac_calcinosis0.78021418
94MP0003279_aneurysm0.77974061
95MP0000372_irregular_coat_pigmentation0.77497687
96MP0002557_abnormal_social/conspecific_i0.77186921
97MP0005645_abnormal_hypothalamus_physiol0.77157856
98MP0005397_hematopoietic_system_phenotyp0.77122312
99MP0001545_abnormal_hematopoietic_system0.77122312
100MP0005390_skeleton_phenotype0.75274346

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)3.80538024
2Mitochondrial inheritance (HP:0001427)3.52597281
3Petechiae (HP:0000967)3.49208450
4Hepatocellular necrosis (HP:0001404)3.48761532
5Acute necrotizing encephalopathy (HP:0006965)3.40115627
6Abnormal mitochondria in muscle tissue (HP:0008316)3.27763236
7Chronic obstructive pulmonary disease (HP:0006510)3.26032726
8Obstructive lung disease (HP:0006536)3.26032726
9Hepatic necrosis (HP:0002605)3.20023674
10Polyphagia (HP:0002591)3.10033149
11Purpura (HP:0000979)3.03270406
12Abnormality of macrophages (HP:0004311)3.02721000
13Stomatitis (HP:0010280)3.00789229
14Myokymia (HP:0002411)2.89474621
15Dysostosis multiplex (HP:0000943)2.83890586
16Eczematoid dermatitis (HP:0000976)2.80766120
17Acute encephalopathy (HP:0006846)2.77812226
18Progressive macrocephaly (HP:0004481)2.75949005
19Prolonged bleeding time (HP:0003010)2.71856626
20Myositis (HP:0100614)2.65744765
21Recurrent abscess formation (HP:0002722)2.62284874
22Recurrent bacterial skin infections (HP:0005406)2.61353125
23Increased CSF lactate (HP:0002490)2.58539519
24Cerebral palsy (HP:0100021)2.55980854
25Abnormality of liposaccharide metabolism (HP:0010968)2.47152021
26Abnormality of glycosphingolipid metabolism (HP:0004343)2.47152021
27Abnormality of glycolipid metabolism (HP:0010969)2.47152021
283-Methylglutaconic aciduria (HP:0003535)2.45638716
29Vacuolated lymphocytes (HP:0001922)2.43108400
30Panhypogammaglobulinemia (HP:0003139)2.32377893
31Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.30781069
32Nasal polyposis (HP:0100582)2.29433501
33Absent rod-and cone-mediated responses on ERG (HP:0007688)2.28275208
34Prolonged neonatal jaundice (HP:0006579)2.27241211
35Systemic lupus erythematosus (HP:0002725)2.26955741
36Abnormal rod and cone electroretinograms (HP:0008323)2.26179225
37Abnormality of the nasal mucosa (HP:0000433)2.26163277
38Renal Fanconi syndrome (HP:0001994)2.25773814
39Abnormality of mucopolysaccharide metabolism (HP:0011020)2.24762451
40Abnormality of polysaccharide metabolism (HP:0011012)2.24762451
41Abnormality of glycosaminoglycan metabolism (HP:0004371)2.24762451
42Abnormality of the heme biosynthetic pathway (HP:0010472)2.21882318
43Hypertensive crisis (HP:0100735)2.20004572
44Papilledema (HP:0001085)2.18629720
45Emotional lability (HP:0000712)2.16590012
46Increased muscle lipid content (HP:0009058)2.15140576
47Increased IgM level (HP:0003496)2.14016757
48Loss of speech (HP:0002371)2.12514465
49Abnormal ciliary motility (HP:0012262)2.11918440
50J-shaped sella turcica (HP:0002680)2.10772372
51Increased intramyocellular lipid droplets (HP:0012240)2.08801044
52Abnormal delayed hypersensitivity skin test (HP:0002963)2.05925491
53Growth hormone excess (HP:0000845)2.05431470
54Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.04769212
55Abnormal eating behavior (HP:0100738)2.04524148
56Mediastinal lymphadenopathy (HP:0100721)2.04193289
57Recurrent fungal infections (HP:0002841)2.02544186
58Flat capital femoral epiphysis (HP:0003370)2.01669140
59Amyloidosis (HP:0011034)1.99831827
60Optic disc pallor (HP:0000543)1.98993378
61Severe visual impairment (HP:0001141)1.96702609
62Epistaxis (HP:0000421)1.93226619
63Joint stiffness (HP:0001387)1.92568127
64Increased IgE level (HP:0003212)1.91555372
65Orchitis (HP:0100796)1.91396750
66Agammaglobulinemia (HP:0004432)1.90357692
67Urinary glycosaminoglycan excretion (HP:0003541)1.90264606
68Mucopolysacchariduria (HP:0008155)1.90264606
69Lactic acidosis (HP:0003128)1.90025865
70Increased serum ferritin (HP:0003281)1.89443104
71Hyperlipoproteinemia (HP:0010980)1.89275503
72Oligomenorrhea (HP:0000876)1.88523436
73Hepatosplenomegaly (HP:0001433)1.85382484
74Agitation (HP:0000713)1.84728831
75Pustule (HP:0200039)1.84379168
76Encephalitis (HP:0002383)1.83425354
77Chronic sinusitis (HP:0011109)1.83344919
78Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.83164790
79Decreased activity of mitochondrial respiratory chain (HP:0008972)1.83164790
80Respiratory failure (HP:0002878)1.82094945
81Muscle fiber atrophy (HP:0100295)1.79529906
82Hyperthyroidism (HP:0000836)1.79156448
83Exertional dyspnea (HP:0002875)1.78985982
84Abnormal pupillary function (HP:0007686)1.78869451
85Axonal loss (HP:0003447)1.77821781
86Meningitis (HP:0001287)1.76114954
87Progressive neurologic deterioration (HP:0002344)1.75961845
88Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.75125571
89Hypergammaglobulinemia (HP:0010702)1.74694823
90Abnormality of dicarboxylic acid metabolism (HP:0010995)1.74061940
91Dicarboxylic aciduria (HP:0003215)1.74061940
92Cerebral edema (HP:0002181)1.73578091
93Gastrointestinal infarctions (HP:0005244)1.73258935
94Delayed CNS myelination (HP:0002188)1.71004585
95Exercise intolerance (HP:0003546)1.70197928
96Abnormal number of erythroid precursors (HP:0012131)1.69865248
97Abnormality of iron homeostasis (HP:0011031)1.69509183
98Retinal dysplasia (HP:0007973)1.69385645
99Hypochromic microcytic anemia (HP:0004840)1.68694377
100Type 2 muscle fiber atrophy (HP:0003554)1.68598691

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK22.75775886
2MAP3K112.51032891
3TNK22.38659772
4EPHB12.31943697
5MAP4K12.25336513
6TESK12.20745235
7MAPK152.11260853
8NME22.06992155
9MAP4K22.05674029
10ERN12.01359080
11VRK21.99068680
12BCKDK1.83990469
13GRK61.83421770
14RIPK41.74720792
15LIMK11.57694940
16SIK31.51788293
17TBK11.49368577
18FES1.44741230
19TYK21.39467189
20DYRK1B1.35584164
21SIK11.34540335
22PIM21.31750258
23MUSK1.31520385
24SIK21.29238573
25TAOK31.24550585
26DYRK21.22521616
27BTK1.17666798
28MAP2K61.16532086
29ZAP701.16449391
30IRAK41.15802073
31MAP2K21.15776881
32MAP3K121.14787110
33EPHB21.14492042
34IKBKB1.10709942
35ARAF1.09398552
36MAP2K31.07272299
37DAPK11.06967004
38MAPKAPK31.06630361
39DAPK21.04707911
40CSK1.04451879
41PRKD31.03306701
42PRKD21.01781898
43BLK0.98400805
44MARK20.95810226
45MARK10.94631239
46IKBKE0.94046583
47TXK0.94039575
48ILK0.92846116
49SYK0.91550454
50GRK50.89809708
51ADRBK20.88974252
52MAPK130.88869025
53TLK10.88448772
54CDK190.88190106
55TAOK10.87001961
56MAP3K60.84411328
57LRRK20.81777165
58PHKG10.81378084
59PHKG20.81378084
60ABL20.78687808
61HCK0.78595269
62MAP2K40.78538615
63TAOK20.78518577
64NME10.76860775
65CAMKK10.76633453
66LYN0.76147550
67MAP2K70.73755570
68STK160.72796868
69MAPK120.72411478
70KDR0.72253616
71MAP3K30.71431801
72HIPK20.70944068
73DAPK30.69883663
74RPS6KA20.69790917
75BRAF0.68613540
76ITK0.67034816
77EPHA30.66295649
78PTK2B0.63768437
79MARK30.62158216
80GRK10.62007066
81MATK0.61599649
82KIT0.60822614
83PKN10.60026141
84CSF1R0.59484251
85TRIB30.57996119
86BMX0.57494427
87TEC0.55986391
88NTRK20.55030262
89LMTK20.54106657
90LCK0.54055504
91PINK10.53245780
92PRPF4B0.52776772
93CSNK1G30.50967619
94EPHA20.50485552
95RPS6KL10.50331645
96RPS6KC10.50331645
97ADRBK10.49514560
98MAPK40.49152600
99PRKCQ0.48036419
100PRKCI0.47691587

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.82747401
2Parkinsons disease_Homo sapiens_hsa050123.07242856
3Collecting duct acid secretion_Homo sapiens_hsa049662.64027126
4Other glycan degradation_Homo sapiens_hsa005112.34211130
5Ribosome_Homo sapiens_hsa030102.22087255
6Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.13098927
7Alzheimers disease_Homo sapiens_hsa050102.08258233
8Sulfur relay system_Homo sapiens_hsa041221.98654703
9Glycosaminoglycan degradation_Homo sapiens_hsa005311.92675918
10Asthma_Homo sapiens_hsa053101.91190399
11Allograft rejection_Homo sapiens_hsa053301.89575292
12alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.72724940
13Synaptic vesicle cycle_Homo sapiens_hsa047211.72590268
14Autoimmune thyroid disease_Homo sapiens_hsa053201.72170516
15Huntingtons disease_Homo sapiens_hsa050161.71699357
16Primary immunodeficiency_Homo sapiens_hsa053401.71444795
17Graft-versus-host disease_Homo sapiens_hsa053321.64416031
18Intestinal immune network for IgA production_Homo sapiens_hsa046721.63947291
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.57137618
20Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.51352356
21Rheumatoid arthritis_Homo sapiens_hsa053231.50197148
22Type I diabetes mellitus_Homo sapiens_hsa049401.50119385
23Cardiac muscle contraction_Homo sapiens_hsa042601.49936730
24Arachidonic acid metabolism_Homo sapiens_hsa005901.45040026
25Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.42169890
26Lysosome_Homo sapiens_hsa041421.40357686
27Staphylococcus aureus infection_Homo sapiens_hsa051501.40224155
28SNARE interactions in vesicular transport_Homo sapiens_hsa041301.34629057
29Linoleic acid metabolism_Homo sapiens_hsa005911.33673000
30Phagosome_Homo sapiens_hsa041451.23568492
31Osteoclast differentiation_Homo sapiens_hsa043801.22945605
32Vibrio cholerae infection_Homo sapiens_hsa051101.18252848
33Regulation of autophagy_Homo sapiens_hsa041401.17218751
34Leishmaniasis_Homo sapiens_hsa051401.14749911
35Cyanoamino acid metabolism_Homo sapiens_hsa004601.13255079
36Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.08542347
37Glutathione metabolism_Homo sapiens_hsa004801.07729176
38Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.03121654
39Tuberculosis_Homo sapiens_hsa051521.02412648
40Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.98578733
41Fatty acid elongation_Homo sapiens_hsa000620.95411236
42Hematopoietic cell lineage_Homo sapiens_hsa046400.94642078
43Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.93253879
44Fructose and mannose metabolism_Homo sapiens_hsa000510.92753801
45Pertussis_Homo sapiens_hsa051330.92368794
46Peroxisome_Homo sapiens_hsa041460.91528015
47Glycerophospholipid metabolism_Homo sapiens_hsa005640.91105822
48Salmonella infection_Homo sapiens_hsa051320.85658846
49Toll-like receptor signaling pathway_Homo sapiens_hsa046200.85172515
50Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.83405594
51Notch signaling pathway_Homo sapiens_hsa043300.82920864
52Ether lipid metabolism_Homo sapiens_hsa005650.82869553
53Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.81336637
54RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.80989947
55Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.77204786
56Antigen processing and presentation_Homo sapiens_hsa046120.76274460
57Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.75538598
58Chemokine signaling pathway_Homo sapiens_hsa040620.70071646
59Proteasome_Homo sapiens_hsa030500.69581787
60Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.67844081
61Phototransduction_Homo sapiens_hsa047440.67630663
62Sulfur metabolism_Homo sapiens_hsa009200.67057937
63Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.66226572
64Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.65679906
65Malaria_Homo sapiens_hsa051440.65443804
66* Endocytosis_Homo sapiens_hsa041440.64364698
67Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.63285655
68Shigellosis_Homo sapiens_hsa051310.60939158
69Morphine addiction_Homo sapiens_hsa050320.60901811
70Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.58790627
71Mineral absorption_Homo sapiens_hsa049780.58189542
72Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.57721090
73Galactose metabolism_Homo sapiens_hsa000520.56183780
74NOD-like receptor signaling pathway_Homo sapiens_hsa046210.55853468
75Cocaine addiction_Homo sapiens_hsa050300.55745980
76Viral myocarditis_Homo sapiens_hsa054160.55520839
77T cell receptor signaling pathway_Homo sapiens_hsa046600.54215146
78Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.53910110
79Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.53711292
80Chemical carcinogenesis_Homo sapiens_hsa052040.52710717
81B cell receptor signaling pathway_Homo sapiens_hsa046620.51826586
82Dopaminergic synapse_Homo sapiens_hsa047280.48120401
83Fat digestion and absorption_Homo sapiens_hsa049750.46674312
84Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.46476316
85NF-kappa B signaling pathway_Homo sapiens_hsa040640.44071724
86GABAergic synapse_Homo sapiens_hsa047270.43045249
87Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.42724394
88Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42669662
89Nitrogen metabolism_Homo sapiens_hsa009100.42098435
90Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.39925419
91Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.39265793
92VEGF signaling pathway_Homo sapiens_hsa043700.38790149
93Platelet activation_Homo sapiens_hsa046110.38049704
94Metabolic pathways_Homo sapiens_hsa011000.38039661
95Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.37591409
96Salivary secretion_Homo sapiens_hsa049700.37251146
97Tyrosine metabolism_Homo sapiens_hsa003500.36390686
98Legionellosis_Homo sapiens_hsa051340.34586966
99Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.34513838
100Circadian entrainment_Homo sapiens_hsa047130.34503746

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