VPS29

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to a group of vacuolar protein sorting (VPS) genes that, when functionally impaired, disrupt the efficient delivery of vacuolar hydrolases. The protein encoded by this gene is a component of a large multimeric complex, termed the retromer complex, which is involved in retrograde transport of proteins from endosomes to the trans-Golgi network. This VPS protein may be involved in the formation of the inner shell of the retromer coat for retrograde vesicles leaving the prevacuolar compartment. Alternative splice variants encoding different isoforms and representing non-protein coding transcripts have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.05260059
2mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.75614111
3ATP synthesis coupled proton transport (GO:0015986)5.68151540
4energy coupled proton transport, down electrochemical gradient (GO:0015985)5.68151540
5protein neddylation (GO:0045116)4.97194679
6respiratory electron transport chain (GO:0022904)4.83029112
7chaperone-mediated protein transport (GO:0072321)4.80256644
8neuron cell-cell adhesion (GO:0007158)4.79047304
9electron transport chain (GO:0022900)4.70646305
10negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.53264138
11presynaptic membrane assembly (GO:0097105)4.38969358
12positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.35352784
13presynaptic membrane organization (GO:0097090)4.26120543
14regulation of cellular amino acid metabolic process (GO:0006521)4.24824354
15regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.19506545
16axon ensheathment in central nervous system (GO:0032291)4.19353695
17central nervous system myelination (GO:0022010)4.19353695
18respiratory chain complex IV assembly (GO:0008535)4.18125270
19DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:004.16201811
20negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.08643976
21negative regulation of ligase activity (GO:0051352)4.08643976
22protein complex biogenesis (GO:0070271)4.06067286
23signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)4.05205355
24signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)4.05205355
25signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)4.05205355
26intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)4.03589946
27signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)4.03589946
28energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.99708628
29ATP hydrolysis coupled proton transport (GO:0015991)3.99708628
30nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.89701185
31anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.89569376
32mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.88886506
33mitochondrial respiratory chain complex I assembly (GO:0032981)3.88886506
34NADH dehydrogenase complex assembly (GO:0010257)3.88886506
35signal transduction involved in DNA integrity checkpoint (GO:0072401)3.83951975
36signal transduction involved in DNA damage checkpoint (GO:0072422)3.83951975
37oxidative phosphorylation (GO:0006119)3.82016336
38long-chain fatty acid biosynthetic process (GO:0042759)3.81372599
39signal transduction involved in cell cycle checkpoint (GO:0072395)3.79640910
40exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.78398625
41synaptic vesicle exocytosis (GO:0016079)3.77576929
42negative regulation of synaptic transmission, GABAergic (GO:0032229)3.74199281
43positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.71005483
44RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.69525975
45tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.69525975
46establishment of protein localization to mitochondrial membrane (GO:0090151)3.61874160
47positive regulation of ligase activity (GO:0051351)3.56623243
48mitochondrial respiratory chain complex assembly (GO:0033108)3.54033038
49transferrin transport (GO:0033572)3.53584910
50neuronal action potential propagation (GO:0019227)3.52289569
51negative regulation of neurotransmitter transport (GO:0051589)3.50959573
52antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.49049545
53hydrogen ion transmembrane transport (GO:1902600)3.46981905
54protein localization to synapse (GO:0035418)3.45995904
55vocalization behavior (GO:0071625)3.43980110
56gamma-aminobutyric acid signaling pathway (GO:0007214)3.41523881
57ribosomal large subunit biogenesis (GO:0042273)3.40054476
58transcription elongation from RNA polymerase III promoter (GO:0006385)3.39959489
59termination of RNA polymerase III transcription (GO:0006386)3.39959489
60DNA deamination (GO:0045006)3.38670563
61regulation of glutamate secretion (GO:0014048)3.38040650
62rRNA modification (GO:0000154)3.37843531
63antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.36517322
64platelet dense granule organization (GO:0060155)3.32070605
65regulation of mitochondrial translation (GO:0070129)3.30402669
66regulation of dopamine metabolic process (GO:0042053)3.30061275
67regulation of catecholamine metabolic process (GO:0042069)3.30061275
68ferric iron transport (GO:0015682)3.26114545
69trivalent inorganic cation transport (GO:0072512)3.26114545
70dopamine transport (GO:0015872)3.25195351
71SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.25048077
72positive regulation of synapse assembly (GO:0051965)3.24812751
73cotranslational protein targeting to membrane (GO:0006613)3.24162492
74regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.21948612
75cullin deneddylation (GO:0010388)3.20900546
76protein targeting to ER (GO:0045047)3.19594588
77proton transport (GO:0015992)3.16814928
78regulation of ubiquitin-protein transferase activity (GO:0051438)3.15547330
79phagosome maturation (GO:0090382)3.14332216
80translation (GO:0006412)3.13542889
81substantia nigra development (GO:0021762)3.13125731
82DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.12824435
83water-soluble vitamin biosynthetic process (GO:0042364)3.12672984
84protein localization to endoplasmic reticulum (GO:0070972)3.12049402
85regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.11504572
86positive regulation of protein homodimerization activity (GO:0090073)3.10624276
87fatty acid elongation (GO:0030497)3.09858400
88hydrogen transport (GO:0006818)3.09796592
89startle response (GO:0001964)3.09340857
90regulation of cellular amine metabolic process (GO:0033238)3.08463345
91regulation of ligase activity (GO:0051340)3.05907207
92establishment of protein localization to endoplasmic reticulum (GO:0072599)3.05729936
93positive regulation of cell cycle arrest (GO:0071158)3.04321428
94postsynaptic membrane organization (GO:0001941)3.03402608
95neuron-neuron synaptic transmission (GO:0007270)3.03313844
96dopamine biosynthetic process (GO:0042416)3.02754804
97glutamate receptor signaling pathway (GO:0007215)3.01856519
98sequestering of actin monomers (GO:0042989)3.00526962
99mitochondrial transport (GO:0006839)3.00467642
100neurotransmitter uptake (GO:0001504)2.99026852
101aerobic respiration (GO:0009060)2.99026505
102CENP-A containing nucleosome assembly (GO:0034080)2.98857224
103deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.97936774
104ionotropic glutamate receptor signaling pathway (GO:0035235)2.97196441
105neuron recognition (GO:0008038)2.96512722
106ribonucleoside triphosphate biosynthetic process (GO:0009201)2.96095430
107ribosomal small subunit assembly (GO:0000028)2.95179666
108negative regulation of protein ubiquitination (GO:0031397)2.90039528
109protein K11-linked ubiquitination (GO:0070979)2.89570587
110signal peptide processing (GO:0006465)2.88912373
111aldehyde catabolic process (GO:0046185)2.87174373
112pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.86093087
113protein deneddylation (GO:0000338)2.85439453
114protein K6-linked ubiquitination (GO:0085020)2.84897464
115regulation of synaptic vesicle exocytosis (GO:2000300)2.83752647
116synaptic transmission, dopaminergic (GO:0001963)2.83092556
117intracellular protein transmembrane import (GO:0044743)2.82708998
118purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.82486678
119purine nucleoside monophosphate biosynthetic process (GO:0009127)2.82486678
120organelle disassembly (GO:1903008)2.81990400
121viral transcription (GO:0019083)2.81553693
122nucleoside triphosphate biosynthetic process (GO:0009142)2.81116420
123translational termination (GO:0006415)2.80514655
124chromatin remodeling at centromere (GO:0031055)2.80471467
125ATP biosynthetic process (GO:0006754)2.79409168
126purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.79379854
127GTP biosynthetic process (GO:0006183)2.79277257
128GPI anchor biosynthetic process (GO:0006506)2.77331229
129rRNA methylation (GO:0031167)2.76897929
130transmission of nerve impulse (GO:0019226)2.75832787
131inner mitochondrial membrane organization (GO:0007007)2.75217315
132protein localization to cilium (GO:0061512)2.75185483
133DNA catabolic process, exonucleolytic (GO:0000738)2.74587325
134mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.73938502
135synaptic transmission, glutamatergic (GO:0035249)2.73919720
136regulation of glutamate receptor signaling pathway (GO:1900449)2.72928530
137proteasome assembly (GO:0043248)2.72501333
138purine nucleoside triphosphate biosynthetic process (GO:0009145)2.72440234
139positive regulation of mitochondrial fission (GO:0090141)2.71681352
140glutamate secretion (GO:0014047)2.71183648
141long-term synaptic potentiation (GO:0060291)2.68233227
142response to histamine (GO:0034776)2.68083457
143behavioral response to cocaine (GO:0048148)2.66778797
144positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.66180679
145serotonin receptor signaling pathway (GO:0007210)2.66135541
146protein targeting to mitochondrion (GO:0006626)2.60496180
147establishment of protein localization to mitochondrion (GO:0072655)2.58972714
148regulation of protein kinase A signaling (GO:0010738)2.57575272
149regulation of short-term neuronal synaptic plasticity (GO:0048172)2.57404889
150negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.56816413
151response to cocaine (GO:0042220)2.56000640
152positive regulation of cellular response to oxidative stress (GO:1900409)2.55620388
153positive regulation of response to oxidative stress (GO:1902884)2.55620388
154regulation of voltage-gated calcium channel activity (GO:1901385)2.51570036
155negative regulation of amino acid transport (GO:0051956)2.51200036
156G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.51046986
157regulation of synapse assembly (GO:0051963)2.50788559
158protein-cofactor linkage (GO:0018065)2.50432219
159regulation of excitatory postsynaptic membrane potential (GO:0060079)2.47852991
160regulation of vesicle fusion (GO:0031338)2.47087952
161regulation of amino acid transport (GO:0051955)2.46369312
162calcium-mediated signaling using intracellular calcium source (GO:0035584)2.45907229
163dendrite development (GO:0016358)2.45669873
164L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.45072594
165regulation of synaptic vesicle transport (GO:1902803)2.44990032
166negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.43321987
167protein localization to mitochondrion (GO:0070585)2.42406589
168cytochrome complex assembly (GO:0017004)2.41572663
169opioid receptor signaling pathway (GO:0038003)2.41016686

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.17505286
2GBX2_23144817_ChIP-Seq_PC3_Human4.10754816
3ELK1_19687146_ChIP-ChIP_HELA_Human3.15101424
4TAF15_26573619_Chip-Seq_HEK293_Human3.03231550
5CREB1_15753290_ChIP-ChIP_HEK293T_Human3.02774841
6ELF1_17652178_ChIP-ChIP_JURKAT_Human2.99571988
7* VDR_23849224_ChIP-Seq_CD4+_Human2.85909126
8ETS1_20019798_ChIP-Seq_JURKAT_Human2.82232523
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.68365216
10TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.65764746
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.51972864
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.49450367
13SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.46700942
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.46667415
15VDR_22108803_ChIP-Seq_LS180_Human2.34200355
16JARID2_20064375_ChIP-Seq_MESCs_Mouse2.33281459
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.31272552
18SRF_21415370_ChIP-Seq_HL-1_Mouse2.30802268
19* FOXP3_21729870_ChIP-Seq_TREG_Human2.29092878
20SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.28446550
21BMI1_23680149_ChIP-Seq_NPCS_Mouse2.26508582
22MYC_18555785_ChIP-Seq_MESCs_Mouse2.22324567
23* E2F4_17652178_ChIP-ChIP_JURKAT_Human2.18004336
24* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.14227343
25CTBP2_25329375_ChIP-Seq_LNCAP_Human2.14074871
26FUS_26573619_Chip-Seq_HEK293_Human2.12408256
27SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.11654854
28CTBP1_25329375_ChIP-Seq_LNCAP_Human2.11420390
29KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.11368477
30P300_19829295_ChIP-Seq_ESCs_Human2.03514253
31EZH2_27304074_Chip-Seq_ESCs_Mouse2.00288583
32PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.96217016
33EED_16625203_ChIP-ChIP_MESCs_Mouse1.96030357
34SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.94420077
35PADI4_21655091_ChIP-ChIP_MCF-7_Human1.92073458
36* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.91910882
37SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.91590050
38JARID2_20075857_ChIP-Seq_MESCs_Mouse1.84118892
39HOXB4_20404135_ChIP-ChIP_EML_Mouse1.81705651
40NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.81230095
41SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.80652678
42GABP_17652178_ChIP-ChIP_JURKAT_Human1.79615692
43REST_21632747_ChIP-Seq_MESCs_Mouse1.78963990
44DCP1A_22483619_ChIP-Seq_HELA_Human1.77579113
45NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.76745317
46CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.76109526
47CBX2_27304074_Chip-Seq_ESCs_Mouse1.72613599
48EZH2_18974828_ChIP-Seq_MESCs_Mouse1.69422156
49RNF2_18974828_ChIP-Seq_MESCs_Mouse1.69422156
50OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.67970232
51HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.66763806
52E2F1_18555785_ChIP-Seq_MESCs_Mouse1.66079240
53* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.65253430
54ER_23166858_ChIP-Seq_MCF-7_Human1.65197699
55MYC_18940864_ChIP-ChIP_HL60_Human1.64606478
56SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.59657623
57EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.59215742
58MTF2_20144788_ChIP-Seq_MESCs_Mouse1.58449979
59TOP2B_26459242_ChIP-Seq_MCF-7_Human1.55690939
60IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.54226081
61MYC_19030024_ChIP-ChIP_MESCs_Mouse1.50360584
62IGF1R_20145208_ChIP-Seq_DFB_Human1.49264773
63RNF2_27304074_Chip-Seq_NSC_Mouse1.49087715
64SMAD4_21799915_ChIP-Seq_A2780_Human1.46590072
65SMAD3_21741376_ChIP-Seq_EPCs_Human1.44522716
66GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.44441003
67EST1_17652178_ChIP-ChIP_JURKAT_Human1.43289987
68FLI1_27457419_Chip-Seq_LIVER_Mouse1.43175296
69FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.43112375
70PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.43049769
71EZH2_27294783_Chip-Seq_ESCs_Mouse1.42498137
72SUZ12_27294783_Chip-Seq_ESCs_Mouse1.41878384
73GABP_19822575_ChIP-Seq_HepG2_Human1.40526240
74PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.39767695
75REST_18959480_ChIP-ChIP_MESCs_Mouse1.38722665
76HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.38238611
77EWS_26573619_Chip-Seq_HEK293_Human1.37998755
78THAP11_20581084_ChIP-Seq_MESCs_Mouse1.37938309
79PCGF2_27294783_Chip-Seq_ESCs_Mouse1.37695456
80ELK1_22589737_ChIP-Seq_MCF10A_Human1.37436442
81* TTF2_22483619_ChIP-Seq_HELA_Human1.37217185
82PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.36717507
83UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.35508521
84JUN_21703547_ChIP-Seq_K562_Human1.34913941
85PIAS1_25552417_ChIP-Seq_VCAP_Human1.33527473
86CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.32370231
87FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.31638644
88IKZF1_21737484_ChIP-ChIP_HCT116_Human1.30762525
89SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.30530082
90RNF2_27304074_Chip-Seq_ESCs_Mouse1.28413537
91NANOG_18555785_Chip-Seq_ESCs_Mouse1.27144098
92AR_21572438_ChIP-Seq_LNCaP_Human1.26572616
93JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.26315316
94CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.25988507
95HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.24815682
96MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.24720987
97EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.23456580
98FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.22373449
99IRF8_21731497_ChIP-ChIP_J774_Mouse1.20336685
100NELFA_20434984_ChIP-Seq_ESCs_Mouse1.18927060
101FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.18580193
102POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.18509836
103TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.17371209
104ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.16855651
105SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.16645700
106CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.16604466
107RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.16191129
108CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.15816875
109PRDM14_20953172_ChIP-Seq_ESCs_Human1.15754322
110* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.14640447
111CMYC_18555785_Chip-Seq_ESCs_Mouse1.14590535
112P53_22387025_ChIP-Seq_ESCs_Mouse1.14082201
113TP53_22573176_ChIP-Seq_HFKS_Human1.13094918
114CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.12767447
115SUZ12_18555785_Chip-Seq_ESCs_Mouse1.12513354
116E2F1_18555785_Chip-Seq_ESCs_Mouse1.12036909
117AR_20517297_ChIP-Seq_VCAP_Human1.10899564
118YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.10886815
119RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.09732624
120AR_25329375_ChIP-Seq_VCAP_Human1.09628652
121* FOXA1_25329375_ChIP-Seq_VCAP_Human1.08826799
122* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.08826799
123GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.08358627
124YY1_21170310_ChIP-Seq_MESCs_Mouse1.08019006
125HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.07889528
126MYC_19079543_ChIP-ChIP_MESCs_Mouse1.07591187
127EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.07559760
128SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.07439860
129STAT3_18555785_Chip-Seq_ESCs_Mouse1.06958987
130TAL1_26923725_Chip-Seq_HPCs_Mouse1.06707196
131SALL4_22934838_ChIP-ChIP_CD34+_Human1.05823476
132P300_18555785_Chip-Seq_ESCs_Mouse1.05353570
133HTT_18923047_ChIP-ChIP_STHdh_Human1.05120958
134CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.03978125
135SOX2_18555785_Chip-Seq_ESCs_Mouse1.03330243
136FOXA1_21572438_ChIP-Seq_LNCaP_Human1.02560176
137PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.02451814
138BP1_19119308_ChIP-ChIP_Hs578T_Human1.02074383
139ZNF274_21170338_ChIP-Seq_K562_Hela1.01902904
140TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01436974
141IRF8_22096565_ChIP-ChIP_GC-B_Human1.00858942
142RUNX2_22187159_ChIP-Seq_PCA_Human1.00523427
143NR3C1_23031785_ChIP-Seq_PC12_Mouse1.00364872
144POU5F1_16153702_ChIP-ChIP_HESCs_Human0.99905527
145CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.98902995
146EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.98443386
147SOX2_19829295_ChIP-Seq_ESCs_Human0.97606675
148NANOG_19829295_ChIP-Seq_ESCs_Human0.97606675
149CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97135346
150EZH2_27294783_Chip-Seq_NPCs_Mouse0.96907782
151MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.96482800
152RUNX1_27457419_Chip-Seq_LIVER_Mouse0.96094439
153SUZ12_27294783_Chip-Seq_NPCs_Mouse0.93925122
154GATA3_26560356_Chip-Seq_TH2_Human0.93678507
155ERG_20517297_ChIP-Seq_VCAP_Human0.93254970
156XRN2_22483619_ChIP-Seq_HELA_Human0.93242333
157NFE2_27457419_Chip-Seq_LIVER_Mouse0.91853064
158IRF1_19129219_ChIP-ChIP_H3396_Human0.86210589
159EGR1_23403033_ChIP-Seq_LIVER_Mouse0.85362787
160ELF5_23300383_ChIP-Seq_T47D_Human0.84597303
161CRX_20693478_ChIP-Seq_RETINA_Mouse0.83241095
162ERG_20887958_ChIP-Seq_HPC-7_Mouse0.82232101
163SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.81357028
164CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.81174565
165* SPI1_23547873_ChIP-Seq_NB4_Human0.80409275
166EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.79391394

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.76955378
2MP0003806_abnormal_nucleotide_metabolis5.14036412
3MP0001529_abnormal_vocalization3.27714870
4MP0004859_abnormal_synaptic_plasticity3.22133242
5MP0001968_abnormal_touch/_nociception3.01532097
6MP0009745_abnormal_behavioral_response2.93616034
7MP0003635_abnormal_synaptic_transmissio2.92200368
8MP0002736_abnormal_nociception_after2.91593544
9MP0003186_abnormal_redox_activity2.89886516
10MP0002064_seizures2.84491242
11MP0001905_abnormal_dopamine_level2.82330039
12MP0008058_abnormal_DNA_repair2.81788542
13MP0006276_abnormal_autonomic_nervous2.76907966
14MP0004270_analgesia2.69460594
15MP0009046_muscle_twitch2.68785075
16MP0002272_abnormal_nervous_system2.64111711
17MP0002063_abnormal_learning/memory/cond2.46922102
18MP0002572_abnormal_emotion/affect_behav2.46684205
19MP0002735_abnormal_chemical_nociception2.39630512
20MP0002734_abnormal_mechanical_nocicepti2.31439192
21MP0001440_abnormal_grooming_behavior2.27406434
22MP0005423_abnormal_somatic_nervous2.27036307
23MP0001188_hyperpigmentation2.24522084
24MP0001486_abnormal_startle_reflex2.24518290
25MP0009697_abnormal_copulation2.17550612
26MP0001835_abnormal_antigen_presentation2.16481069
27MP0003786_premature_aging2.12215382
28MP0003195_calcinosis2.08273017
29MP0004142_abnormal_muscle_tone2.08139019
30MP0009379_abnormal_foot_pigmentation2.05635217
31MP0005671_abnormal_response_to2.02154289
32MP0008877_abnormal_DNA_methylation2.00942875
33MP0002067_abnormal_sensory_capabilities1.91961760
34MP0001501_abnormal_sleep_pattern1.91502713
35MP0001970_abnormal_pain_threshold1.91451137
36MP0005171_absent_coat_pigmentation1.90719071
37MP0000778_abnormal_nervous_system1.87396341
38MP0005075_abnormal_melanosome_morpholog1.84115103
39MP0002733_abnormal_thermal_nociception1.82463475
40MP0003136_yellow_coat_color1.75272675
41MP0003718_maternal_effect1.74569866
42MP0000920_abnormal_myelination1.70775557
43MP0001984_abnormal_olfaction1.68308736
44MP0010094_abnormal_chromosome_stability1.67999774
45MP0004742_abnormal_vestibular_system1.67124785
46MP0009785_altered_susceptibility_to1.66171702
47MP0004924_abnormal_behavior1.65633844
48MP0005386_behavior/neurological_phenoty1.65633844
49MP0002822_catalepsy1.64590780
50MP0001764_abnormal_homeostasis1.64201208
51MP0005646_abnormal_pituitary_gland1.61324494
52MP0008875_abnormal_xenobiotic_pharmacok1.61003906
53MP0002148_abnormal_hypersensitivity_rea1.57342921
54MP0002277_abnormal_respiratory_mucosa1.56719162
55MP0002184_abnormal_innervation1.54583806
56MP0002938_white_spotting1.53173760
57MP0008007_abnormal_cellular_replicative1.49756197
58MP0005409_darkened_coat_color1.49196185
59MP0005408_hypopigmentation1.49160310
60MP0010386_abnormal_urinary_bladder1.43625035
61MP0005645_abnormal_hypothalamus_physiol1.42302946
62MP0003122_maternal_imprinting1.42112958
63MP0002557_abnormal_social/conspecific_i1.40583191
64MP0002876_abnormal_thyroid_physiology1.40058802
65MP0004957_abnormal_blastocyst_morpholog1.39321936
66MP0005551_abnormal_eye_electrophysiolog1.39311147
67MP0008995_early_reproductive_senescence1.36346887
68MP0003011_delayed_dark_adaptation1.35766262
69MP0003724_increased_susceptibility_to1.32237953
70MP0001986_abnormal_taste_sensitivity1.31278932
71MP0003329_amyloid_beta_deposits1.31251707
72MP0002638_abnormal_pupillary_reflex1.30133302
73MP0004215_abnormal_myocardial_fiber1.25585318
74MP0002066_abnormal_motor_capabilities/c1.24151820
75MP0002882_abnormal_neuron_morphology1.24116308
76MP0002837_dystrophic_cardiac_calcinosis1.23060410
77MP0005332_abnormal_amino_acid1.22719285
78MP0009764_decreased_sensitivity_to1.22274984
79MP0000372_irregular_coat_pigmentation1.20464278
80MP0001502_abnormal_circadian_rhythm1.17138092
81MP0002163_abnormal_gland_morphology1.17134987
82MP0001963_abnormal_hearing_physiology1.15347858
83MP0005636_abnormal_mineral_homeostasis1.15204415
84MP0002229_neurodegeneration1.14559524
85MP0005379_endocrine/exocrine_gland_phen1.13292181
86MP0001485_abnormal_pinna_reflex1.11432870
87MP0003693_abnormal_embryo_hatching1.09964822
88MP0000955_abnormal_spinal_cord1.07650374
89MP0002095_abnormal_skin_pigmentation1.07338501
90MP0000358_abnormal_cell_content/1.03070723
91MP0008569_lethality_at_weaning1.02049850
92MP0003634_abnormal_glial_cell1.01810918
93MP0001853_heart_inflammation1.00481895
94MP0006292_abnormal_olfactory_placode0.99778754
95MP0002752_abnormal_somatic_nervous0.99711462
96MP0004811_abnormal_neuron_physiology0.98396329
97MP0005266_abnormal_metabolism0.97526156
98MP0005367_renal/urinary_system_phenotyp0.96229299
99MP0000516_abnormal_urinary_system0.96229299
100MP0002139_abnormal_hepatobiliary_system0.96019606
101MP0000026_abnormal_inner_ear0.94676623
102MP0002234_abnormal_pharynx_morphology0.94314906
103MP0003879_abnormal_hair_cell0.91915721
104MP0003631_nervous_system_phenotype0.91675387
105MP0004043_abnormal_pH_regulation0.91282460
106MP0003077_abnormal_cell_cycle0.90866741
107MP0000631_abnormal_neuroendocrine_gland0.89618615
108MP0002166_altered_tumor_susceptibility0.88299738
109MP0006035_abnormal_mitochondrial_morpho0.87980054
110MP0003633_abnormal_nervous_system0.87778971
111MP0002006_tumorigenesis0.87120601
112MP0008873_increased_physiological_sensi0.86788279
113MP0005085_abnormal_gallbladder_physiolo0.86730228
114MP0001800_abnormal_humoral_immune0.84557925
115MP0008932_abnormal_embryonic_tissue0.84361143
116MP0002090_abnormal_vision0.83877426
117MP0003787_abnormal_imprinting0.83421591
118MP0002102_abnormal_ear_morphology0.83378066
119MP0001929_abnormal_gametogenesis0.82607438
120MP0000343_altered_response_to0.82380452
121MP0005253_abnormal_eye_physiology0.81954784
122MP0002452_abnormal_antigen_presenting0.81888721
123MP0006082_CNS_inflammation0.81568331
124MP0005389_reproductive_system_phenotype0.81293622
125MP0003252_abnormal_bile_duct0.81144828
126MP0006072_abnormal_retinal_apoptosis0.79137913
127MP0002152_abnormal_brain_morphology0.78217496
128MP0002210_abnormal_sex_determination0.77543313
129MP0003137_abnormal_impulse_conducting0.76493039
130MP0003632_abnormal_nervous_system0.76187849
131MP0000015_abnormal_ear_pigmentation0.76160710
132MP0008260_abnormal_autophagy0.76084085
133MP0005499_abnormal_olfactory_system0.76065096
134MP0005394_taste/olfaction_phenotype0.76065096
135MP0001919_abnormal_reproductive_system0.75918982
136MP0005410_abnormal_fertilization0.74563218
137MP0001664_abnormal_digestion0.74083195
138MP0001756_abnormal_urination0.73874968
139MP0008872_abnormal_physiological_respon0.72606020
140MP0002751_abnormal_autonomic_nervous0.72329559
141MP0005376_homeostasis/metabolism_phenot0.72050400
142MP0002723_abnormal_immune_serum0.71929918
143MP0001845_abnormal_inflammatory_respons0.71592618
144MP0006054_spinal_hemorrhage0.71453146
145MP0005000_abnormal_immune_tolerance0.70988759
146MP0003690_abnormal_glial_cell0.70761303
147MP0008469_abnormal_protein_level0.69198750
148MP0005084_abnormal_gallbladder_morpholo0.68204780
149MP0000653_abnormal_sex_gland0.67832010
150MP0001727_abnormal_embryo_implantation0.67771737
151MP0000647_abnormal_sebaceous_gland0.67371064
152MP0004885_abnormal_endolymph0.67013469
153MP0006036_abnormal_mitochondrial_physio0.65172176
154MP0005535_abnormal_body_temperature0.64061082
155MP0003938_abnormal_ear_development0.61797224
156MP0003950_abnormal_plasma_membrane0.61553068
157MP0001177_atelectasis0.61393639
158MP0002069_abnormal_eating/drinking_beha0.61186126
159MP0004145_abnormal_muscle_electrophysio0.60568668
160MP0001542_abnormal_bone_strength0.59868879
161MP0004147_increased_porphyrin_level0.58744502
162MP0008789_abnormal_olfactory_epithelium0.58744387
163MP0000604_amyloidosis0.57494584

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.94559423
2Abnormal mitochondria in muscle tissue (HP:0008316)5.29261639
3Progressive macrocephaly (HP:0004481)5.09035764
4Mitochondrial inheritance (HP:0001427)5.05994703
5Focal motor seizures (HP:0011153)4.99792326
6Acute encephalopathy (HP:0006846)4.61990897
7Abnormality of glycolysis (HP:0004366)4.19141136
8Increased serum pyruvate (HP:0003542)4.19141136
9Increased CSF lactate (HP:0002490)4.16971010
10Hepatocellular necrosis (HP:0001404)4.02161377
11Atonic seizures (HP:0010819)3.65877899
12Increased hepatocellular lipid droplets (HP:0006565)3.60424125
13Epileptic encephalopathy (HP:0200134)3.49686911
14Renal Fanconi syndrome (HP:0001994)3.45576926
15Myokymia (HP:0002411)3.43283479
16Optic disc pallor (HP:0000543)3.35888031
17Leukodystrophy (HP:0002415)3.25764777
18Neuroendocrine neoplasm (HP:0100634)3.09922270
19Medial flaring of the eyebrow (HP:0010747)3.09217104
20Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.08586645
21Hyperventilation (HP:0002883)3.08585347
22Congenital, generalized hypertrichosis (HP:0004540)3.05347178
233-Methylglutaconic aciduria (HP:0003535)3.05107245
24Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.04898828
25Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.04623751
26Pheochromocytoma (HP:0002666)3.04505377
27Aplastic anemia (HP:0001915)3.00554635
28Hepatic necrosis (HP:0002605)2.97720171
29Gait imbalance (HP:0002141)2.93185785
30Lipid accumulation in hepatocytes (HP:0006561)2.92155255
31Exercise intolerance (HP:0003546)2.86497082
32Limb dystonia (HP:0002451)2.86357464
33Focal seizures (HP:0007359)2.86042441
34Absence seizures (HP:0002121)2.85859724
35Respiratory failure (HP:0002878)2.85114712
36Febrile seizures (HP:0002373)2.83681011
37Methylmalonic aciduria (HP:0012120)2.82573076
38Parakeratosis (HP:0001036)2.81718277
39Abnormal hair whorl (HP:0010721)2.77477141
40Congenital primary aphakia (HP:0007707)2.75610784
41Cerebral edema (HP:0002181)2.70645199
42Nephrogenic diabetes insipidus (HP:0009806)2.67529198
43Dialeptic seizures (HP:0011146)2.66418635
44Lethargy (HP:0001254)2.65700244
45Type I transferrin isoform profile (HP:0003642)2.64096864
46Neurofibrillary tangles (HP:0002185)2.63008299
47Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.61979878
48Degeneration of the lateral corticospinal tracts (HP:0002314)2.61979878
49Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.55151533
50Abnormality of alanine metabolism (HP:0010916)2.55151533
51Hyperalaninemia (HP:0003348)2.55151533
52Lactic acidosis (HP:0003128)2.54892803
53Pancreatic cysts (HP:0001737)2.53359899
54Hypothermia (HP:0002045)2.47932370
55Retinal dysplasia (HP:0007973)2.47781478
56Vaginal atresia (HP:0000148)2.45574585
57Molar tooth sign on MRI (HP:0002419)2.43589810
58Abnormality of midbrain morphology (HP:0002418)2.43589810
59X-linked dominant inheritance (HP:0001423)2.43007292
60Increased serum lactate (HP:0002151)2.41523900
61Genital tract atresia (HP:0001827)2.41363853
62Progressive cerebellar ataxia (HP:0002073)2.40564484
63Broad-based gait (HP:0002136)2.39768738
64Abnormality of renal resorption (HP:0011038)2.39224210
65Abnormality of aspartate family amino acid metabolism (HP:0010899)2.37568599
66Abnormality of methionine metabolism (HP:0010901)2.37342606
67Abnormality of urine glucose concentration (HP:0011016)2.36758257
68Glycosuria (HP:0003076)2.36758257
69Increased intramyocellular lipid droplets (HP:0012240)2.36165565
70Visual hallucinations (HP:0002367)2.31638787
71Sensory axonal neuropathy (HP:0003390)2.26609407
72Generalized aminoaciduria (HP:0002909)2.23399094
73Exertional dyspnea (HP:0002875)2.21473830
74Generalized tonic-clonic seizures (HP:0002069)2.21018484
75Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.16581672
76Decreased activity of mitochondrial respiratory chain (HP:0008972)2.16581672
77Macrocytic anemia (HP:0001972)2.16396632
78Polyphagia (HP:0002591)2.15548856
79Abnormal number of erythroid precursors (HP:0012131)2.13459299
80Delusions (HP:0000746)2.12812850
81Cerebral inclusion bodies (HP:0100314)2.12653321
82Abnormal pupillary function (HP:0007686)2.12384459
83Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.12296983
84Abnormal protein N-linked glycosylation (HP:0012347)2.12296983
85Abnormal protein glycosylation (HP:0012346)2.12296983
86Abnormal glycosylation (HP:0012345)2.12296983
87Pancreatic fibrosis (HP:0100732)2.10304240
88Abnormality of serum amino acid levels (HP:0003112)2.09909687
89Degeneration of anterior horn cells (HP:0002398)2.09806280
90Abnormality of the anterior horn cell (HP:0006802)2.09806280
91Abnormality of dicarboxylic acid metabolism (HP:0010995)2.07816489
92Dicarboxylic aciduria (HP:0003215)2.07816489
93Progressive inability to walk (HP:0002505)2.07261139
94Renal cortical cysts (HP:0000803)2.06765897
95Anxiety (HP:0000739)2.05674545
96Amniotic constriction ring (HP:0009775)2.04342031
97Abnormality of placental membranes (HP:0011409)2.04342031
98True hermaphroditism (HP:0010459)2.01725256
99Abnormality of vitamin B metabolism (HP:0004340)2.01147480
100Cerebral hypomyelination (HP:0006808)1.98546731
101Esotropia (HP:0000565)1.97846115
102Abnormality of cells of the erythroid lineage (HP:0012130)1.96910710
103Poor suck (HP:0002033)1.93738292
104Hyperphosphaturia (HP:0003109)1.93711668
105Respiratory difficulties (HP:0002880)1.91690916
106Oral leukoplakia (HP:0002745)1.91210138
107Abnormality of the vitamin B12 metabolism (HP:0004341)1.90667036
108Inability to walk (HP:0002540)1.90315890
109Abnormality of the corticospinal tract (HP:0002492)1.89844756
110Cerebral hemorrhage (HP:0001342)1.89620128
111Pancytopenia (HP:0001876)1.89497999
112Autoamputation (HP:0001218)1.89135688
113Supranuclear gaze palsy (HP:0000605)1.88943887
114Emotional lability (HP:0000712)1.88802605
115Amblyopia (HP:0000646)1.86834190
116Congenital ichthyosiform erythroderma (HP:0007431)1.84302632
117Poor coordination (HP:0002370)1.83002437
118Nephronophthisis (HP:0000090)1.80795925
119Aplasia/Hypoplasia of the lens (HP:0008063)1.80537041
120Palpitations (HP:0001962)1.79650537
121Reduced antithrombin III activity (HP:0001976)1.78632983
122Abnormal ciliary motility (HP:0012262)1.78595424
123Aplasia/hypoplasia of the uterus (HP:0008684)1.74983590
124Abnormal eating behavior (HP:0100738)1.74449879
125Abnormality of the renal cortex (HP:0011035)1.74374688
126Hyperglycinemia (HP:0002154)1.74281954
127Blindness (HP:0000618)1.73262258
128Methylmalonic acidemia (HP:0002912)1.73212074
129Scanning speech (HP:0002168)1.72516698
130Dysmetria (HP:0001310)1.71876051
131Dynein arm defect of respiratory motile cilia (HP:0012255)1.71219791
132Absent/shortened dynein arms (HP:0200106)1.71219791
133Constricted visual fields (HP:0001133)1.69846191
134Specific learning disability (HP:0001328)1.69410614
135Microvesicular hepatic steatosis (HP:0001414)1.68978973
136Abnormality of aromatic amino acid family metabolism (HP:0004338)1.68781281
137Nausea (HP:0002018)1.68419864
138CNS demyelination (HP:0007305)1.67923060
139Diplopia (HP:0000651)1.66001371
140Abnormality of binocular vision (HP:0011514)1.66001371
141Progressive microcephaly (HP:0000253)1.65895277
142Metabolic acidosis (HP:0001942)1.65393057
143Delayed CNS myelination (HP:0002188)1.65109976
144Abnormal respiratory motile cilium morphology (HP:0005938)1.63203373
145Abnormal respiratory epithelium morphology (HP:0012253)1.63203373
146Abolished electroretinogram (ERG) (HP:0000550)1.63014634
147Increased muscle lipid content (HP:0009058)1.62674156
148Epileptiform EEG discharges (HP:0011182)1.61454882
149Gaze-evoked nystagmus (HP:0000640)1.60753843
150Abnormal spermatogenesis (HP:0008669)1.59569012
151Progressive external ophthalmoplegia (HP:0000590)1.58864625
152Hypomagnesemia (HP:0002917)1.58335037
153Generalized myoclonic seizures (HP:0002123)1.57086808
154Type 2 muscle fiber atrophy (HP:0003554)1.56220077
155Pallor (HP:0000980)1.54962994
156Megaloblastic anemia (HP:0001889)1.54723789

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.37296028
2MAP3K123.56811244
3VRK23.36817312
4MAP4K22.51619520
5MAP2K72.43469912
6OXSR12.39635393
7STK392.35401759
8NTRK32.30165272
9STK162.29781526
10TRIM282.25356929
11PNCK2.19853750
12EPHA42.17591226
13NME12.16076367
14PLK22.15817500
15ZAK2.07617210
16NUAK12.01322284
17MARK12.01109696
18PBK1.99644541
19RIPK41.97910174
20CDK191.97015184
21BCR1.95530417
22ARAF1.93712765
23TNIK1.92745548
24SRPK11.89776077
25MST41.87335008
26MAP3K41.78886139
27BMPR21.71541591
28NEK11.64741663
29BMPR1B1.61793028
30MINK11.61387314
31TXK1.53047166
32LIMK11.52775846
33GRK51.50383902
34BCKDK1.44315563
35MAPKAPK51.42890353
36FRK1.42442976
37GRK71.40666746
38ACVR1B1.32935630
39NME21.29923365
40PLK41.28950232
41WNK41.28861503
42CAMK2B1.28073463
43MAPK131.26150156
44ADRBK21.24167617
45CAMK2A1.15212828
46PDK21.14188142
47TAOK31.09850098
48MYLK1.08339468
49GRK11.06012024
50CDC71.04718657
51PRPF4B1.02155092
52MAP2K41.01893277
53FGR1.01290072
54WEE10.99618356
55NTRK20.99486954
56WNK30.98997475
57INSRR0.98396238
58BRAF0.97916481
59BUB10.97411603
60CCNB10.96959843
61EIF2AK20.96567821
62DYRK20.93957449
63MUSK0.93733535
64KDR0.92973166
65TESK10.91889938
66VRK10.91824326
67FES0.91619812
68UHMK10.91314092
69PRKCG0.90856579
70DAPK10.90332252
71CAMK2D0.89150075
72PRKCE0.88284052
73BRSK20.87491405
74CSNK1G30.86669160
75SCYL20.85193564
76TEC0.84693896
77CDK140.83187326
78AKT30.80886350
79PTK2B0.80671920
80PAK40.80520440
81MAP3K90.80490043
82CDK50.80090227
83PKN10.79940007
84SIK30.78384166
85ADRBK10.77563555
86CDK180.75902490
87TSSK60.75898911
88NTRK10.75794699
89NEK60.75294937
90EIF2AK10.74460855
91ILK0.74451241
92PLK10.71314232
93CAMKK20.70728860
94CSNK1G20.70360903
95CDK150.69539923
96EIF2AK30.69091958
97SGK2230.68640830
98SGK4940.68640830
99PINK10.66661232
100IKBKB0.66580777
101ROCK20.66342064
102CAMK2G0.65812453
103TLK10.65775183
104KIT0.62578165
105RPS6KA40.62550818
106DAPK20.62439107
107CDK11A0.62177768
108TTK0.58781304
109DYRK1A0.57783110
110YES10.56001008
111CSNK2A10.55165378
112RPS6KA50.52247738
113AURKB0.51729931
114TESK20.51587707
115TAF10.51007143
116DYRK30.50363805
117CSNK2A20.49417463
118ABL20.48247568
119CDK80.47299067
120OBSCN0.47043829
121DAPK30.46836342
122PLK30.46547211
123CSNK1G10.46008664
124TGFBR10.45982468
125MKNK10.45790966
126PHKG20.44349001
127PHKG10.44349001
128IRAK20.43510229
129PRKACA0.43294571
130CSNK1A1L0.41531949
131STK100.40837878
132IRAK40.38773106
133ATR0.38598730
134LYN0.37706613
135CSF1R0.37662741
136STK38L0.36564047
137PRKCQ0.36433156
138FLT30.35893651
139WNK10.35230158
140IKBKE0.35064920
141KSR10.33057920
142PIM20.32990477
143MAP3K130.32307048
144CDK30.31450791
145PRKG10.30750635
146CSNK1A10.30355706
147MOS0.28242926
148MKNK20.28029446
149ERBB30.27855061
150PAK30.26859944

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001905.17385800
2Parkinsons disease_Homo sapiens_hsa050124.11910669
3Collecting duct acid secretion_Homo sapiens_hsa049663.35035130
4Alzheimers disease_Homo sapiens_hsa050103.34677836
5Nicotine addiction_Homo sapiens_hsa050333.15662590
6Huntingtons disease_Homo sapiens_hsa050162.91472224
7Proteasome_Homo sapiens_hsa030502.88822373
8Synaptic vesicle cycle_Homo sapiens_hsa047212.71028931
9Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.25697843
10Protein export_Homo sapiens_hsa030602.24001673
11Vibrio cholerae infection_Homo sapiens_hsa051102.22277537
12Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.21937103
13Mismatch repair_Homo sapiens_hsa034302.17765226
14Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.15149825
15Homologous recombination_Homo sapiens_hsa034402.08950918
16Cardiac muscle contraction_Homo sapiens_hsa042601.98637389
17Serotonergic synapse_Homo sapiens_hsa047261.86223561
18GABAergic synapse_Homo sapiens_hsa047271.85004423
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.77764488
20Morphine addiction_Homo sapiens_hsa050321.71910858
21DNA replication_Homo sapiens_hsa030301.66818039
22Phototransduction_Homo sapiens_hsa047441.66037872
23Rheumatoid arthritis_Homo sapiens_hsa053231.61724293
24Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.59162250
25RNA polymerase_Homo sapiens_hsa030201.57352708
26Glutamatergic synapse_Homo sapiens_hsa047241.56283277
27Circadian entrainment_Homo sapiens_hsa047131.51520873
28Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.51452770
29Nucleotide excision repair_Homo sapiens_hsa034201.50828133
30Propanoate metabolism_Homo sapiens_hsa006401.49613984
31Amphetamine addiction_Homo sapiens_hsa050311.48114265
32Ribosome_Homo sapiens_hsa030101.47784317
33Taste transduction_Homo sapiens_hsa047421.47121125
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.46026760
35SNARE interactions in vesicular transport_Homo sapiens_hsa041301.45018577
36Dopaminergic synapse_Homo sapiens_hsa047281.40659109
37RNA degradation_Homo sapiens_hsa030181.35211417
38Fatty acid elongation_Homo sapiens_hsa000621.34697310
39Long-term potentiation_Homo sapiens_hsa047201.34339934
40Steroid biosynthesis_Homo sapiens_hsa001001.29829082
41Long-term depression_Homo sapiens_hsa047301.28145191
42Olfactory transduction_Homo sapiens_hsa047401.27495273
43Fanconi anemia pathway_Homo sapiens_hsa034601.26045855
44Intestinal immune network for IgA production_Homo sapiens_hsa046721.26039139
45Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.22381851
46Non-homologous end-joining_Homo sapiens_hsa034501.21491202
47Spliceosome_Homo sapiens_hsa030401.21032367
48Base excision repair_Homo sapiens_hsa034101.19521402
49Phagosome_Homo sapiens_hsa041451.16751161
50Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.16531494
51Ether lipid metabolism_Homo sapiens_hsa005651.11570825
52One carbon pool by folate_Homo sapiens_hsa006701.09661358
53Folate biosynthesis_Homo sapiens_hsa007901.09495958
54Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.07662476
55Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.06177395
56Cocaine addiction_Homo sapiens_hsa050301.02515080
57Salivary secretion_Homo sapiens_hsa049700.98165572
58Renin secretion_Homo sapiens_hsa049240.97284908
59Peroxisome_Homo sapiens_hsa041460.96127849
60Cholinergic synapse_Homo sapiens_hsa047250.93227897
61Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.92322945
62RNA transport_Homo sapiens_hsa030130.89440157
63Calcium signaling pathway_Homo sapiens_hsa040200.86217483
64Antigen processing and presentation_Homo sapiens_hsa046120.83845525
65Type I diabetes mellitus_Homo sapiens_hsa049400.79340098
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.79299679
67Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.77573233
68Axon guidance_Homo sapiens_hsa043600.77122148
69Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.75612024
70Chemical carcinogenesis_Homo sapiens_hsa052040.75545230
71Tryptophan metabolism_Homo sapiens_hsa003800.74662828
72Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.72073374
73Sulfur metabolism_Homo sapiens_hsa009200.70662728
74Sphingolipid metabolism_Homo sapiens_hsa006000.70246084
75Gastric acid secretion_Homo sapiens_hsa049710.69754076
76Insulin secretion_Homo sapiens_hsa049110.69662616
77Primary bile acid biosynthesis_Homo sapiens_hsa001200.68650702
78Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.65547335
79Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65218129
80Cysteine and methionine metabolism_Homo sapiens_hsa002700.63667540
81Pentose and glucuronate interconversions_Homo sapiens_hsa000400.63374799
82Nitrogen metabolism_Homo sapiens_hsa009100.62816982
83Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.62494313
84Drug metabolism - other enzymes_Homo sapiens_hsa009830.61552377
85Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.60841850
86Gap junction_Homo sapiens_hsa045400.60305840
87Autoimmune thyroid disease_Homo sapiens_hsa053200.60082452
88Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.58997190
89Oxytocin signaling pathway_Homo sapiens_hsa049210.57943935
90Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.57906543
91Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.57630309
92Graft-versus-host disease_Homo sapiens_hsa053320.54324502
93Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.54217276
94Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.53201737
95Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.52782147
96Basal transcription factors_Homo sapiens_hsa030220.52665488
97Maturity onset diabetes of the young_Homo sapiens_hsa049500.52201399
98African trypanosomiasis_Homo sapiens_hsa051430.50934119
99Primary immunodeficiency_Homo sapiens_hsa053400.50395230
100Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49147823
101Allograft rejection_Homo sapiens_hsa053300.48912598
102Caffeine metabolism_Homo sapiens_hsa002320.46968785
103Regulation of autophagy_Homo sapiens_hsa041400.46474045
104Purine metabolism_Homo sapiens_hsa002300.45200626
105Arachidonic acid metabolism_Homo sapiens_hsa005900.45139123
106Metabolic pathways_Homo sapiens_hsa011000.44874178
107Vascular smooth muscle contraction_Homo sapiens_hsa042700.44454383
108Asthma_Homo sapiens_hsa053100.44403167
109Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.43763761
110Alcoholism_Homo sapiens_hsa050340.42783238
111beta-Alanine metabolism_Homo sapiens_hsa004100.42567344
112Fatty acid degradation_Homo sapiens_hsa000710.42051739
113Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.41795407
114Viral myocarditis_Homo sapiens_hsa054160.39671156
115Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.39644686
116Carbon metabolism_Homo sapiens_hsa012000.39078147
117Steroid hormone biosynthesis_Homo sapiens_hsa001400.38479374
118Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.38432681
119Pyruvate metabolism_Homo sapiens_hsa006200.37391649
120GnRH signaling pathway_Homo sapiens_hsa049120.36399564
121Legionellosis_Homo sapiens_hsa051340.36104788
122Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.35782284
123Staphylococcus aureus infection_Homo sapiens_hsa051500.35611665
124Ras signaling pathway_Homo sapiens_hsa040140.35084383
125Retinol metabolism_Homo sapiens_hsa008300.34089065
126Pyrimidine metabolism_Homo sapiens_hsa002400.33524287
127Aldosterone synthesis and secretion_Homo sapiens_hsa049250.33137838
128Hematopoietic cell lineage_Homo sapiens_hsa046400.32192403
129Systemic lupus erythematosus_Homo sapiens_hsa053220.31355357
1302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.31156190
131Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.29183727
132Epstein-Barr virus infection_Homo sapiens_hsa051690.29096671
133Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.28244926
134Cell cycle_Homo sapiens_hsa041100.27749455
135cAMP signaling pathway_Homo sapiens_hsa040240.27481658
136Fatty acid metabolism_Homo sapiens_hsa012120.27201246
137Sphingolipid signaling pathway_Homo sapiens_hsa040710.26084834
138Selenocompound metabolism_Homo sapiens_hsa004500.26067118
139Melanogenesis_Homo sapiens_hsa049160.26014270
140Oocyte meiosis_Homo sapiens_hsa041140.25749199
141Tyrosine metabolism_Homo sapiens_hsa003500.21650881
142Butanoate metabolism_Homo sapiens_hsa006500.21607875
143Linoleic acid metabolism_Homo sapiens_hsa005910.20783864
144Mineral absorption_Homo sapiens_hsa049780.20412501
145Pancreatic secretion_Homo sapiens_hsa049720.18829945
146Vitamin B6 metabolism_Homo sapiens_hsa007500.17727184
147Salmonella infection_Homo sapiens_hsa051320.16860346
148Glutathione metabolism_Homo sapiens_hsa004800.16443554
149Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.15014382
150Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.12992306
151cGMP-PKG signaling pathway_Homo sapiens_hsa040220.12272311
152Lysosome_Homo sapiens_hsa041420.12153821
153MAPK signaling pathway_Homo sapiens_hsa040100.10658332
154ErbB signaling pathway_Homo sapiens_hsa040120.10381025

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