VPS33B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene is a member of the Sec-1 domain family, and encodes the human ortholog of rat Vps33b which is homologous to the yeast class C Vps33 protein. The mammalian class C vacuolar protein sorting proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. Mutations in this gene are associated with arthrogryposis-renal dysfunction-cholestasis syndrome. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1daunorubicin metabolic process (GO:0044597)6.74823495
2polyketide metabolic process (GO:0030638)6.74823495
3doxorubicin metabolic process (GO:0044598)6.74823495
4neuron cell-cell adhesion (GO:0007158)5.07867829
5pyrimidine dimer repair (GO:0006290)4.59872696
6base-excision repair, AP site formation (GO:0006285)4.40957295
7pyrimidine nucleotide catabolic process (GO:0006244)4.14963912
8pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.00352367
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.96501865
10establishment of mitochondrion localization (GO:0051654)3.95880134
11behavioral response to nicotine (GO:0035095)3.89034062
12aminoglycoside antibiotic metabolic process (GO:0030647)3.83596822
13regulation of somitogenesis (GO:0014807)3.81577456
14tRNA methylation (GO:0030488)3.79404088
15positive regulation of protein homooligomerization (GO:0032464)3.75400527
16adenosine metabolic process (GO:0046085)3.65223500
17response to pheromone (GO:0019236)3.38842302
18negative regulation of cAMP-mediated signaling (GO:0043951)3.30774053
19glycine transport (GO:0015816)3.24388209
20meiotic chromosome segregation (GO:0045132)3.24146887
21microtubule nucleation (GO:0007020)3.22213057
22peptidyl-arginine omega-N-methylation (GO:0035247)3.19495620
23piRNA metabolic process (GO:0034587)3.17938545
24regulation of translation in response to stress (GO:0043555)3.17035144
25negative regulation of telomere maintenance (GO:0032205)3.14410297
26cellular copper ion homeostasis (GO:0006878)3.11663231
27mitochondrion transport along microtubule (GO:0047497)3.10034362
28establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.10034362
29mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.00114073
30positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.00114073
31DNA deamination (GO:0045006)2.97143347
32negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.96118039
33DNA methylation involved in gamete generation (GO:0043046)2.93097837
34negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.92952471
35mitochondrial RNA metabolic process (GO:0000959)2.92849372
36interferon-gamma production (GO:0032609)2.90300519
37resolution of meiotic recombination intermediates (GO:0000712)2.90001339
38peptidyl-arginine methylation (GO:0018216)2.86484486
39peptidyl-arginine N-methylation (GO:0035246)2.86484486
40negative regulation of DNA-templated transcription, elongation (GO:0032785)2.82958179
41rRNA methylation (GO:0031167)2.80336283
42histone H2A acetylation (GO:0043968)2.78269717
43deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.75136082
44mannose metabolic process (GO:0006013)2.74523239
45response to misfolded protein (GO:0051788)2.74128647
46mast cell activation (GO:0045576)2.73796831
47ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.73594848
48positive regulation of protein oligomerization (GO:0032461)2.71233250
49rRNA modification (GO:0000154)2.69704564
50mitochondrial respiratory chain complex I assembly (GO:0032981)2.69214207
51NADH dehydrogenase complex assembly (GO:0010257)2.69214207
52mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.69214207
53positive regulation of gamma-delta T cell activation (GO:0046645)2.65188803
54regulation of nuclear cell cycle DNA replication (GO:0033262)2.63829189
55positive regulation of T cell apoptotic process (GO:0070234)2.63537175
56histone H3-K4 trimethylation (GO:0080182)2.62425405
57exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.62119353
58copper ion transport (GO:0006825)2.61224791
59lipid phosphorylation (GO:0046834)2.61007168
60RNA methylation (GO:0001510)2.60891532
61gamma-aminobutyric acid transport (GO:0015812)2.59706440
62misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.58006940
63protoporphyrinogen IX metabolic process (GO:0046501)2.57628986
64transcription from mitochondrial promoter (GO:0006390)2.57623467
65positive regulation of mast cell activation (GO:0033005)2.57315356
66CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.55313909
67deoxyribonucleotide catabolic process (GO:0009264)2.54107357
68phosphatidylinositol phosphorylation (GO:0046854)2.53939238
69protoporphyrinogen IX biosynthetic process (GO:0006782)2.53369602
70spliceosomal tri-snRNP complex assembly (GO:0000244)2.53324726
71intra-S DNA damage checkpoint (GO:0031573)2.53302721
72negative regulation of interleukin-1 production (GO:0032692)2.50861881
73nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.49775305
74lymphoid progenitor cell differentiation (GO:0002320)2.49404346
75preassembly of GPI anchor in ER membrane (GO:0016254)2.48894628
76histone H3-K36 demethylation (GO:0070544)2.48363769
77telomere maintenance via semi-conservative replication (GO:0032201)2.47948690
78organic cation transport (GO:0015695)2.46853170
79regulation of B cell receptor signaling pathway (GO:0050855)2.46850112
80endosome to pigment granule transport (GO:0043485)2.46721003
81endosome to melanosome transport (GO:0035646)2.46721003
82male meiosis I (GO:0007141)2.46221066
83proteasome assembly (GO:0043248)2.45426055
84snRNA processing (GO:0016180)2.45374315
85regulation of meiosis I (GO:0060631)2.44613353
86CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.44204144
87T-helper cell differentiation (GO:0042093)2.44204144
88response to muramyl dipeptide (GO:0032495)2.44104578
89positive regulation of lymphocyte apoptotic process (GO:0070230)2.43219881
90positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.41742448
91sensory perception of taste (GO:0050909)2.41056766
92positive regulation of granulocyte differentiation (GO:0030854)2.40487297
93tRNA modification (GO:0006400)2.40411676
94regulation of mitotic spindle checkpoint (GO:1903504)2.39417900
95regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.39417900
96copper ion homeostasis (GO:0055070)2.39249312
97regulation of defense response to virus by host (GO:0050691)2.38181353
98DNA integration (GO:0015074)2.37248717
99energy homeostasis (GO:0097009)2.37197197
100DNA synthesis involved in DNA repair (GO:0000731)2.37127210
101regulation of immunoglobulin secretion (GO:0051023)2.36940853
102Arp2/3 complex-mediated actin nucleation (GO:0034314)2.35494856
103NIK/NF-kappaB signaling (GO:0038061)2.34950256
104deoxyribose phosphate catabolic process (GO:0046386)2.33625071
105auditory receptor cell stereocilium organization (GO:0060088)2.32663752
106histamine secretion (GO:0001821)2.32604879
107histone arginine methylation (GO:0034969)2.32537653
108serotonin metabolic process (GO:0042428)2.32443813
109phosphorelay signal transduction system (GO:0000160)2.31715220
110detection of molecule of bacterial origin (GO:0032490)2.31388400
111telomere maintenance via recombination (GO:0000722)2.31378277
112B cell homeostasis (GO:0001782)2.29920625
113lymphocyte homeostasis (GO:0002260)2.29597763
114kinetochore assembly (GO:0051382)2.28841572
115termination of RNA polymerase I transcription (GO:0006363)2.28493485
116pseudouridine synthesis (GO:0001522)2.28387805
117T cell homeostasis (GO:0043029)2.27140910
118DNA catabolic process, exonucleolytic (GO:0000738)2.26717551
119histone H2A monoubiquitination (GO:0035518)2.26687142
120histone mRNA catabolic process (GO:0071044)2.26335527
121CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.25601174
122protein complex biogenesis (GO:0070271)2.25301433
123leukocyte aggregation (GO:0070486)2.25139858
124maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.24972765
125mast cell activation involved in immune response (GO:0002279)2.24461727
126mast cell degranulation (GO:0043303)2.24461727
127tRNA processing (GO:0008033)2.24138430
128adaptation of signaling pathway (GO:0023058)2.23579125
129negative regulation of interleukin-1 beta production (GO:0032691)2.23543838
130transcription elongation from RNA polymerase I promoter (GO:0006362)2.23464103
131iron-sulfur cluster assembly (GO:0016226)2.23276996
132metallo-sulfur cluster assembly (GO:0031163)2.23276996
133negative regulation of RNA splicing (GO:0033119)2.22744399
134positive regulation of defense response to virus by host (GO:0002230)2.22146364
135negative regulation of DNA-dependent DNA replication (GO:2000104)2.22021328
136regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.20981606
137histamine transport (GO:0051608)2.20871543
138developmental pigmentation (GO:0048066)2.20734349
139negative T cell selection (GO:0043383)2.19743241
140rRNA catabolic process (GO:0016075)2.19238260
141termination of RNA polymerase III transcription (GO:0006386)2.19116785
142transcription elongation from RNA polymerase III promoter (GO:0006385)2.19116785
143histone mRNA metabolic process (GO:0008334)2.18766790
144pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.18420692
145regulation of T cell receptor signaling pathway (GO:0050856)2.17739538
146alpha-beta T cell differentiation involved in immune response (GO:0002293)2.17294102
147alpha-beta T cell activation involved in immune response (GO:0002287)2.17294102
148T cell differentiation involved in immune response (GO:0002292)2.17294102
149centriole assembly (GO:0098534)2.17121773
150interferon-gamma secretion (GO:0072643)2.16809053
151positive regulation of RNA splicing (GO:0033120)2.16592099
152cellular anion homeostasis (GO:0030002)2.16529324
153response to interferon-alpha (GO:0035455)2.15712912
154negative regulation of mRNA processing (GO:0050686)2.15109904
155CD4-positive, alpha-beta T cell activation (GO:0035710)2.14530987
156norepinephrine metabolic process (GO:0042415)2.14507213
157negative regulation of transcription regulatory region DNA binding (GO:2000678)2.14492285
158GPI anchor metabolic process (GO:0006505)2.12755828
159cell migration in hindbrain (GO:0021535)2.12621037
160positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.12501196
161GPI anchor biosynthetic process (GO:0006506)2.12458717
162cellular response to interferon-beta (GO:0035458)2.12435670
163lymph node development (GO:0048535)2.11681257
164glycoside metabolic process (GO:0016137)2.11675429
165CENP-A containing nucleosome assembly (GO:0034080)2.11127171
166negative thymic T cell selection (GO:0045060)2.10683572
167histone H4-K16 acetylation (GO:0043984)2.10490527
168motile cilium assembly (GO:0044458)2.10355027
169cellular response to interleukin-15 (GO:0071350)2.10215295
170protein insertion into membrane (GO:0051205)2.10009845
171RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.09994776
172positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.09638053
173positive regulation of type 2 immune response (GO:0002830)2.09393090
174mitochondrial respiratory chain complex assembly (GO:0033108)2.09231686
175regulation of metalloenzyme activity (GO:0048552)2.08916056
176positive regulation of B cell differentiation (GO:0045579)2.08725569
177snRNA metabolic process (GO:0016073)2.08605445
178positive regulation of interleukin-4 production (GO:0032753)2.08368831
179L-fucose catabolic process (GO:0042355)2.07819474
180fucose catabolic process (GO:0019317)2.07819474
181L-fucose metabolic process (GO:0042354)2.07819474
182ER overload response (GO:0006983)2.07775430
183postsynaptic membrane organization (GO:0001941)2.07367527
184alpha-beta T cell activation (GO:0046631)2.07097491
185negative regulation of transcription by competitive promoter binding (GO:0010944)2.06702896
186replicative senescence (GO:0090399)2.06520631
187B cell receptor signaling pathway (GO:0050853)2.05790450
188DNA demethylation (GO:0080111)2.05235668
189positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.04594192
190regulation of B cell differentiation (GO:0045577)2.04195010

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.49346341
2E2F7_22180533_ChIP-Seq_HELA_Human4.42912722
3TP63_19390658_ChIP-ChIP_HaCaT_Human2.72788217
4IRF8_22096565_ChIP-ChIP_GC-B_Human2.70484361
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.69865538
6CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.66453132
7ELF1_17652178_ChIP-ChIP_JURKAT_Human2.47787834
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.42895453
9VDR_21846776_ChIP-Seq_THP-1_Human2.35094761
10GABP_19822575_ChIP-Seq_HepG2_Human2.33787163
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.26364894
12NOTCH1_21737748_ChIP-Seq_TLL_Human2.25034320
13NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.23094259
14SCL_19346495_ChIP-Seq_HPC-7_Human2.19984274
15FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.19638895
16SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.17020743
17* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.16384630
18GABP_17652178_ChIP-ChIP_JURKAT_Human2.12795832
19EST1_17652178_ChIP-ChIP_JURKAT_Human2.10027130
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.09989541
21XRN2_22483619_ChIP-Seq_HELA_Human2.09219724
22HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.06604422
23HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.01520408
24FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.97686822
25IRF1_19129219_ChIP-ChIP_H3396_Human1.97175454
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.97053577
27SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.96264817
28* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.95555086
29FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.95370505
30SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.94276133
31* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.92488959
32SRF_21415370_ChIP-Seq_HL-1_Mouse1.90699786
33VDR_23849224_ChIP-Seq_CD4+_Human1.90299481
34E2F4_17652178_ChIP-ChIP_JURKAT_Human1.90089312
35MYC_22102868_ChIP-Seq_BL_Human1.89935214
36MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.87426582
37GBX2_23144817_ChIP-Seq_PC3_Human1.84572050
38HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.78585277
39IGF1R_20145208_ChIP-Seq_DFB_Human1.77731704
40PHF8_20622854_ChIP-Seq_HELA_Human1.75179960
41TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.74526337
42* FOXP3_21729870_ChIP-Seq_TREG_Human1.74140425
43DCP1A_22483619_ChIP-Seq_HELA_Human1.73903833
44P68_20966046_ChIP-Seq_HELA_Human1.71407009
45YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.70879090
46PCGF2_27294783_Chip-Seq_ESCs_Mouse1.70738592
47TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.67265821
48CREB1_15753290_ChIP-ChIP_HEK293T_Human1.67055922
49YY1_21170310_ChIP-Seq_MESCs_Mouse1.65696073
50LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.62215163
51RBPJ_22232070_ChIP-Seq_NCS_Mouse1.61870955
52FLI1_27457419_Chip-Seq_LIVER_Mouse1.60468490
53* ELF1_20517297_ChIP-Seq_JURKAT_Human1.59709155
54IRF8_21731497_ChIP-ChIP_J774_Mouse1.59240863
55ELK1_19687146_ChIP-ChIP_HELA_Human1.57888685
56CIITA_25753668_ChIP-Seq_RAJI_Human1.56761710
57SPI1_23547873_ChIP-Seq_NB4_Human1.56728150
58SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.56591843
59CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.55186810
60DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.54483507
61CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.51997806
62CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.50300620
63BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.49822002
64EWS_26573619_Chip-Seq_HEK293_Human1.49681337
65BCL6_27268052_Chip-Seq_Bcells_Human1.47735973
66REST_18959480_ChIP-ChIP_MESCs_Mouse1.47203042
67* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.46332874
68* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.45085293
69THAP11_20581084_ChIP-Seq_MESCs_Mouse1.43933501
70E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.42802807
71SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.41870174
72KDM5A_27292631_Chip-Seq_BREAST_Human1.41292235
73CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.40872569
74IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.40538736
75ZFP57_27257070_Chip-Seq_ESCs_Mouse1.40134303
76ETS1_20019798_ChIP-Seq_JURKAT_Human1.39573598
77FOXP1_21924763_ChIP-Seq_HESCs_Human1.38660895
78MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.38490597
79GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.36783417
80TET1_21451524_ChIP-Seq_MESCs_Mouse1.36741120
81EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.35918451
82FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.34653412
83NFE2_27457419_Chip-Seq_LIVER_Mouse1.34145020
84POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.33273918
85E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.32792652
86TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.31657335
87TFEB_21752829_ChIP-Seq_HELA_Human1.31368325
88SUZ12_27294783_Chip-Seq_NPCs_Mouse1.31012402
89* MYC_18555785_ChIP-Seq_MESCs_Mouse1.30626149
90E2F1_20622854_ChIP-Seq_HELA_Human1.30352218
91MAF_26560356_Chip-Seq_TH2_Human1.29378081
92GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.29004226
93EZH2_22144423_ChIP-Seq_EOC_Human1.26929031
94RUNX_20019798_ChIP-Seq_JUKART_Human1.26481613
95TTF2_22483619_ChIP-Seq_HELA_Human1.25909081
96YY1_22570637_ChIP-Seq_MALME-3M_Human1.24680129
97CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.23982204
98POU3F2_20337985_ChIP-ChIP_501MEL_Human1.23125771
99RARB_24833708_ChIP-Seq_LIVER_Mouse1.23118592
100UTX_26944678_Chip-Seq_JUKART_Human1.22315313
101* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.21445013
102ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.21315320
103MYC_18358816_ChIP-ChIP_MESCs_Mouse1.21041984
104MAF_26560356_Chip-Seq_TH1_Human1.21029952
105CTCF_18555785_ChIP-Seq_MESCs_Mouse1.20770631
106SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.20743245
107BCOR_27268052_Chip-Seq_Bcells_Human1.19593514
108SMAD_19615063_ChIP-ChIP_OVARY_Human1.19425970
109FUS_26573619_Chip-Seq_HEK293_Human1.19036564
110FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.18667765
111STAT4_19710469_ChIP-ChIP_TH1__Mouse1.18634478
112E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.18545624
113MYC_18940864_ChIP-ChIP_HL60_Human1.17301666
114CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.16295887
115PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.15523956
116MYC_19030024_ChIP-ChIP_MESCs_Mouse1.15376099
117TP53_22127205_ChIP-Seq_IMR90_Human1.15138707
118LXR_22292898_ChIP-Seq_THP-1_Human1.13954291
119RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.13888693
120SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.13308582
121CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12061867
122REST_21632747_ChIP-Seq_MESCs_Mouse1.10996541
123STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.10459412
124EZH2_27294783_Chip-Seq_NPCs_Mouse1.08965644
125PU.1_20513432_ChIP-Seq_Bcells_Mouse1.08753016
126NANOG_18555785_Chip-Seq_ESCs_Mouse1.08434848
127* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07543599
128RAC3_21632823_ChIP-Seq_H3396_Human1.07300228
129ERG_21242973_ChIP-ChIP_JURKAT_Human1.06843692
130STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.06686557
131SUZ12_18555785_Chip-Seq_ESCs_Mouse1.05993393
132ERA_21632823_ChIP-Seq_H3396_Human1.05974502
133STAT3_18555785_Chip-Seq_ESCs_Mouse1.05647432
134EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.05439387
135CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.04473214
136PCGF2_27294783_Chip-Seq_NPCs_Mouse1.04074653
137SMC4_20622854_ChIP-Seq_HELA_Human1.04053989
138E2F1_18555785_Chip-Seq_ESCs_Mouse1.04009188
139CTCF_26484167_Chip-Seq_Bcells_Mouse1.03508083
140BP1_19119308_ChIP-ChIP_Hs578T_Human1.03324807
141SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.02889236
142PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.02812212
143* CTCF_20526341_ChIP-Seq_ESCs_Human1.01827790
144MYB_26560356_Chip-Seq_TH2_Human1.01347584
145CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.01282756
146OCT4_19829295_ChIP-Seq_ESCs_Human1.00479687
147EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99873590
148P53_22387025_ChIP-Seq_ESCs_Mouse0.97593897
149NMYC_18555785_Chip-Seq_ESCs_Mouse0.97399674
150* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.97268766
151TAF15_26573619_Chip-Seq_HEK293_Human0.97120386
152TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96990153
153CMYC_18555785_Chip-Seq_ESCs_Mouse0.95850329
154E2F1_21310950_ChIP-Seq_MCF-7_Human0.95249577
155CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.95079901
156POU5F1_16153702_ChIP-ChIP_HESCs_Human0.94152904
157KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.94060840
158RUNX1_27457419_Chip-Seq_LIVER_Mouse0.93752328
159SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.93127048
160IRF8_27001747_Chip-Seq_BMDM_Mouse0.92345518

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode3.27238855
2MP0002396_abnormal_hematopoietic_system3.19126916
3MP0009697_abnormal_copulation3.09534776
4MP0002132_abnormal_respiratory_system2.99429577
5MP0002163_abnormal_gland_morphology2.91917708
6MP0004885_abnormal_endolymph2.79254672
7MP0005423_abnormal_somatic_nervous2.60416701
8MP0005171_absent_coat_pigmentation2.60399912
9MP0002277_abnormal_respiratory_mucosa2.51478541
10MP0003806_abnormal_nucleotide_metabolis2.47930758
11MP0008058_abnormal_DNA_repair2.46430159
12MP0005379_endocrine/exocrine_gland_phen2.32494343
13MP0003763_abnormal_thymus_physiology2.30734926
14MP0006035_abnormal_mitochondrial_morpho2.30116984
15MP0003183_abnormal_peptide_metabolism2.27918395
16MP0005671_abnormal_response_to2.27557144
17MP0010094_abnormal_chromosome_stability2.15429687
18MP0001835_abnormal_antigen_presentation2.10047853
19MP0005645_abnormal_hypothalamus_physiol2.07187887
20MP0008995_early_reproductive_senescence2.04802266
21MP0003693_abnormal_embryo_hatching2.00813494
22MP0005174_abnormal_tail_pigmentation2.00589381
23MP0003787_abnormal_imprinting2.00222849
24MP0001188_hyperpigmentation1.97199391
25MP0005646_abnormal_pituitary_gland1.83179518
26MP0001986_abnormal_taste_sensitivity1.78091338
27MP0003880_abnormal_central_pattern1.77726859
28MP0003111_abnormal_nucleus_morphology1.76010749
29MP0002095_abnormal_skin_pigmentation1.75389201
30MP0000015_abnormal_ear_pigmentation1.74014761
31MP0000372_irregular_coat_pigmentation1.73550666
32MP0000569_abnormal_digit_pigmentation1.73419760
33MP0001800_abnormal_humoral_immune1.72323607
34MP0002822_catalepsy1.69154132
35MP0004859_abnormal_synaptic_plasticity1.68840120
36MP0005075_abnormal_melanosome_morpholog1.68491895
37MP0008057_abnormal_DNA_replication1.63682916
38MP0001790_abnormal_immune_system1.63004897
39MP0005387_immune_system_phenotype1.63004897
40MP0002398_abnormal_bone_marrow1.58332977
41MP0001984_abnormal_olfaction1.54764733
42MP0003077_abnormal_cell_cycle1.52866859
43MP0003172_abnormal_lysosome_physiology1.52722248
44MP0009785_altered_susceptibility_to1.51876734
45MP0002452_abnormal_antigen_presenting1.51169310
46MP0003646_muscle_fatigue1.50465837
47MP0001968_abnormal_touch/_nociception1.50302351
48MP0008007_abnormal_cellular_replicative1.49855183
49MP0002420_abnormal_adaptive_immunity1.49722823
50MP0002063_abnormal_learning/memory/cond1.49079867
51MP0001819_abnormal_immune_cell1.46875751
52MP0003635_abnormal_synaptic_transmissio1.46150535
53MP0008260_abnormal_autophagy1.44682187
54MP0002653_abnormal_ependyma_morphology1.43527188
55MP0002148_abnormal_hypersensitivity_rea1.43428307
56MP0002723_abnormal_immune_serum1.41000834
57MP0004142_abnormal_muscle_tone1.39825140
58MP0002075_abnormal_coat/hair_pigmentati1.37668470
59MP0008877_abnormal_DNA_methylation1.36845655
60MP0006276_abnormal_autonomic_nervous1.36084514
61MP0002102_abnormal_ear_morphology1.35825528
62MP0000371_diluted_coat_color1.33927533
63MP0000685_abnormal_immune_system1.33416045
64MP0002736_abnormal_nociception_after1.32964190
65MP0002938_white_spotting1.32834976
66MP0000716_abnormal_immune_system1.32785733
67MP0005025_abnormal_response_to1.32543395
68MP0000566_synostosis1.31629941
69MP0001873_stomach_inflammation1.28824670
70MP0001186_pigmentation_phenotype1.27983557
71MP0003329_amyloid_beta_deposits1.27467643
72MP0000490_abnormal_crypts_of1.26486869
73MP0005409_darkened_coat_color1.25254448
74MP0002638_abnormal_pupillary_reflex1.24613418
75MP0005000_abnormal_immune_tolerance1.23664048
76MP0000778_abnormal_nervous_system1.22353839
77MP0000358_abnormal_cell_content/1.21203847
78MP0008789_abnormal_olfactory_epithelium1.21120596
79MP0004811_abnormal_neuron_physiology1.17744848
80MP0003866_abnormal_defecation1.17668833
81MP0009764_decreased_sensitivity_to1.17319203
82MP0000689_abnormal_spleen_morphology1.15256137
83MP0006036_abnormal_mitochondrial_physio1.14852971
84MP0010386_abnormal_urinary_bladder1.14625054
85MP0004043_abnormal_pH_regulation1.14272320
86MP0000681_abnormal_thyroid_gland1.13859974
87MP0002722_abnormal_immune_system1.12810952
88MP0000703_abnormal_thymus_morphology1.11979846
89MP0004808_abnormal_hematopoietic_stem1.11314038
90MP0002429_abnormal_blood_cell1.10905940
91MP0004381_abnormal_hair_follicle1.10343897
92MP0002572_abnormal_emotion/affect_behav1.09837108
93MP0001919_abnormal_reproductive_system1.09778668
94MP0009333_abnormal_splenocyte_physiolog1.09402423
95MP0001348_abnormal_lacrimal_gland1.09205885
96MP0002405_respiratory_system_inflammati1.06982456
97MP0002138_abnormal_hepatobiliary_system1.06791826
98MP0001502_abnormal_circadian_rhythm1.04575548
99MP0002006_tumorigenesis1.04153707
100MP0002419_abnormal_innate_immunity1.02290801
101MP0002210_abnormal_sex_determination1.01385714
102MP0005464_abnormal_platelet_physiology1.00569926
103MP0001440_abnormal_grooming_behavior1.00409633
104MP0009745_abnormal_behavioral_response0.99898495
105MP0003786_premature_aging0.99319885
106MP0003121_genomic_imprinting0.98240356
107MP0005551_abnormal_eye_electrophysiolog0.96807972
108MP0002098_abnormal_vibrissa_morphology0.96516895
109MP0004147_increased_porphyrin_level0.95678057
110MP0004133_heterotaxia0.95218862
111MP0002272_abnormal_nervous_system0.94874521
112MP0001324_abnormal_eye_pigmentation0.93114455
113MP0005394_taste/olfaction_phenotype0.92669901
114MP0005499_abnormal_olfactory_system0.92669901
115MP0000613_abnormal_salivary_gland0.91553762
116MP0005397_hematopoietic_system_phenotyp0.91079073
117MP0001545_abnormal_hematopoietic_system0.91079073
118MP0002166_altered_tumor_susceptibility0.91055026
119MP0000604_amyloidosis0.89468054
120MP0009765_abnormal_xenobiotic_induced0.88563747
121MP0003941_abnormal_skin_development0.87051947
122MP0008569_lethality_at_weaning0.86833847
123MP0002229_neurodegeneration0.86279853
124MP0003123_paternal_imprinting0.85626480
125MP0003656_abnormal_erythrocyte_physiolo0.85314686
126MP0002557_abnormal_social/conspecific_i0.84850544
127MP0003724_increased_susceptibility_to0.84461121
128MP0002882_abnormal_neuron_morphology0.84180754
129MP0003122_maternal_imprinting0.83696335
130MP0001764_abnormal_homeostasis0.83132634
131MP0004742_abnormal_vestibular_system0.82633184
132MP0001529_abnormal_vocalization0.81203809
133MP0000465_gastrointestinal_hemorrhage0.80908631
134MP0002064_seizures0.79320068
135MP0002067_abnormal_sensory_capabilities0.79080352
136MP0003436_decreased_susceptibility_to0.78892978
137MP0005310_abnormal_salivary_gland0.78155489
138MP0003698_abnormal_male_reproductive0.78095691
139MP0002735_abnormal_chemical_nociception0.77818414
140MP0004957_abnormal_blastocyst_morpholog0.77234108
141MP0002970_abnormal_white_adipose0.76749175
142MP0003879_abnormal_hair_cell0.75544382
143MP0001119_abnormal_female_reproductive0.75200473
144MP0002009_preneoplasia0.73717495
145MP0000678_abnormal_parathyroid_gland0.73712489
146MP0008004_abnormal_stomach_pH0.67664104
147MP0000631_abnormal_neuroendocrine_gland0.67455171
148MP0000313_abnormal_cell_death0.66924950
149MP0002160_abnormal_reproductive_system0.66509888
150MP0010155_abnormal_intestine_physiology0.65689435
151MP0001845_abnormal_inflammatory_respons0.64572072
152MP0003136_yellow_coat_color0.63785449
153MP0005389_reproductive_system_phenotype0.62951925

Predicted human phenotypes

RankGene SetZ-score
1Hyperactive renin-angiotensin system (HP:0000841)4.20242938
2Entropion (HP:0000621)4.09792786
3Decreased circulating renin level (HP:0003351)4.00079433
4Hypothermia (HP:0002045)3.91904528
5Chronic bronchitis (HP:0004469)3.79545062
6Hyperaldosteronism (HP:0000859)3.66467838
7Chromosomal breakage induced by crosslinking agents (HP:0003221)3.60987372
8Chromsome breakage (HP:0040012)3.56742349
9Poikiloderma (HP:0001029)3.56587132
10Hypokalemic alkalosis (HP:0001949)3.51834262
11Abnormality of cells of the erythroid lineage (HP:0012130)3.36402237
12Abnormal number of erythroid precursors (HP:0012131)3.36282480
1311 pairs of ribs (HP:0000878)3.20244007
14Congenital stationary night blindness (HP:0007642)3.05475198
15Chronic diarrhea (HP:0002028)2.95887646
16Abnormality of chloride homeostasis (HP:0011422)2.94059375
17Hyponatremia (HP:0002902)2.90018245
18Abnormality of the renal collecting system (HP:0004742)2.89624579
19IgM deficiency (HP:0002850)2.89080825
20Renal salt wasting (HP:0000127)2.81095521
21CNS hypomyelination (HP:0003429)2.78696537
22Abnormal hair whorl (HP:0010721)2.73019071
23Delusions (HP:0000746)2.68551051
24Chronic otitis media (HP:0000389)2.62847404
25Microvesicular hepatic steatosis (HP:0001414)2.59651145
26Type I transferrin isoform profile (HP:0003642)2.58844603
27Birth length less than 3rd percentile (HP:0003561)2.58835776
28True hermaphroditism (HP:0010459)2.57296852
29Bronchitis (HP:0012387)2.56598041
30Pancreatic fibrosis (HP:0100732)2.55502551
31Abnormality of DNA repair (HP:0003254)2.55446741
32Duplicated collecting system (HP:0000081)2.55218358
33Bronchiectasis (HP:0002110)2.54644409
34Recurrent pneumonia (HP:0006532)2.54430055
35Cutaneous melanoma (HP:0012056)2.50236940
36Osteomalacia (HP:0002749)2.45894988
37Cerebral hypomyelination (HP:0006808)2.44979100
38Abnormality of the preputium (HP:0100587)2.44677340
39Abnormality of cochlea (HP:0000375)2.43645805
40Mutism (HP:0002300)2.42974131
41Abnormality of the columella (HP:0009929)2.41643606
42Stomatitis (HP:0010280)2.35415879
43Febrile seizures (HP:0002373)2.34276410
44Cheilitis (HP:0100825)2.33711953
45Prostate neoplasm (HP:0100787)2.33701689
46Absent rod-and cone-mediated responses on ERG (HP:0007688)2.32125451
47Squamous cell carcinoma (HP:0002860)2.31783458
48Basal cell carcinoma (HP:0002671)2.30638848
49Ectopic kidney (HP:0000086)2.27477131
50Patchy hypopigmentation of hair (HP:0011365)2.27212773
51Pancreatic cysts (HP:0001737)2.25598145
52White forelock (HP:0002211)2.24638310
53Clubbing of toes (HP:0100760)2.23579523
54Recurrent abscess formation (HP:0002722)2.23225492
55Elevated erythrocyte sedimentation rate (HP:0003565)2.22560168
56Reticulocytopenia (HP:0001896)2.21281133
57Abnormality of sodium homeostasis (HP:0010931)2.19643328
58Aplasia/Hypoplasia of the uvula (HP:0010293)2.17366187
59Pachygyria (HP:0001302)2.16243158
60Dynein arm defect of respiratory motile cilia (HP:0012255)2.15872803
61Absent/shortened dynein arms (HP:0200106)2.15872803
62Lip pit (HP:0100267)2.15723893
63Chronic sinusitis (HP:0011109)2.11324675
64Medial flaring of the eyebrow (HP:0010747)2.10895668
65Abnormality of chromosome stability (HP:0003220)2.10715890
66IgG deficiency (HP:0004315)2.09707107
67Large eyes (HP:0001090)2.09378908
68Agammaglobulinemia (HP:0004432)2.09321097
69Recurrent sinusitis (HP:0011108)2.08111312
70Spastic tetraplegia (HP:0002510)2.05903718
71Myokymia (HP:0002411)2.05824767
72Alkalosis (HP:0001948)2.05796743
73Petechiae (HP:0000967)2.05294500
74Hepatocellular necrosis (HP:0001404)2.04947718
75Abnormality of the prostate (HP:0008775)2.04871476
76Lymphopenia (HP:0001888)2.04672471
77Personality changes (HP:0000751)2.04536216
78Spontaneous hematomas (HP:0007420)2.04157261
79Abnormal delayed hypersensitivity skin test (HP:0002963)2.03520928
80Spastic gait (HP:0002064)2.02971839
81Nephronophthisis (HP:0000090)2.02970903
82Chronic mucocutaneous candidiasis (HP:0002728)2.00530161
83Recurrent cutaneous fungal infections (HP:0011370)2.00530161
84Myelodysplasia (HP:0002863)2.00304472
85Metabolic alkalosis (HP:0200114)1.98967427
86Aplastic anemia (HP:0001915)1.98408827
87Septo-optic dysplasia (HP:0100842)1.97204692
88Meckel diverticulum (HP:0002245)1.96665349
89Osteomyelitis (HP:0002754)1.96568696
90Thyroid-stimulating hormone excess (HP:0002925)1.96420410
91Neuronal loss in central nervous system (HP:0002529)1.96391713
92Epileptic encephalopathy (HP:0200134)1.95614717
93Abnormality of the fingertips (HP:0001211)1.95601654
94Hyperkalemia (HP:0002153)1.92984562
95Abnormality of renin-angiotensin system (HP:0000847)1.92640852
96Mediastinal lymphadenopathy (HP:0100721)1.92355739
97Abnormality of reticulocytes (HP:0004312)1.91429420
98Abnormality of the ileum (HP:0001549)1.91103280
99Gastrointestinal stroma tumor (HP:0100723)1.90003870
100Abnormality of glycolipid metabolism (HP:0010969)1.89971287
101Abnormality of liposaccharide metabolism (HP:0010968)1.89971287
102Abnormality of glycosphingolipid metabolism (HP:0004343)1.89971287
103Rectal prolapse (HP:0002035)1.89899765
104Abnormality of the carotid arteries (HP:0005344)1.88871336
105Parakeratosis (HP:0001036)1.88782625
106Polyphagia (HP:0002591)1.88613944
107Premature ovarian failure (HP:0008209)1.88293152
108Hypokalemia (HP:0002900)1.88288298
109Optic nerve coloboma (HP:0000588)1.87957034
110Cutaneous photosensitivity (HP:0000992)1.87398677
111Progressive microcephaly (HP:0000253)1.86805955
112Polymicrogyria (HP:0002126)1.86784350
113* Lissencephaly (HP:0001339)1.86572683
114Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.85486908
115Tubulointerstitial abnormality (HP:0001969)1.84797861
116Abnormality of cells of the lymphoid lineage (HP:0012140)1.84608426
117Type 2 muscle fiber atrophy (HP:0003554)1.83403066
118Aplasia cutis congenita (HP:0001057)1.83363854
119Abnormality of the renal medulla (HP:0100957)1.82859577
120Emotional lability (HP:0000712)1.82109827
121Panhypogammaglobulinemia (HP:0003139)1.81525489
122Recurrent lower respiratory tract infections (HP:0002783)1.80650959
123Lymphoma (HP:0002665)1.80403737
124Tubulointerstitial nephritis (HP:0001970)1.80080272
125Pallor (HP:0000980)1.79782928
126Morphological abnormality of the inner ear (HP:0011390)1.78271927
127Decreased electroretinogram (ERG) amplitude (HP:0000654)1.77285475
128Bone marrow hypocellularity (HP:0005528)1.77103386
129Absent thumb (HP:0009777)1.76348050
130Drooling (HP:0002307)1.76279073
131Abnormality of transition element cation homeostasis (HP:0011030)1.76140905
132Excessive salivation (HP:0003781)1.76051512
133Hypoproteinemia (HP:0003075)1.75678539
134Spinal muscular atrophy (HP:0007269)1.75634007
135Abnormal rod and cone electroretinograms (HP:0008323)1.75612459
136Myositis (HP:0100614)1.75214080
137Progressive cerebellar ataxia (HP:0002073)1.74734734
138Recurrent bronchitis (HP:0002837)1.74633361
139Progressive inability to walk (HP:0002505)1.74049412
140Colon cancer (HP:0003003)1.73908457
141Premature graying of hair (HP:0002216)1.73655807
142Ragged-red muscle fibers (HP:0003200)1.73040626
143Neoplasm of head and neck (HP:0012288)1.72884037
144Esophageal neoplasm (HP:0100751)1.72884037
145Severe visual impairment (HP:0001141)1.72877843
146B lymphocytopenia (HP:0010976)1.72346777
147Abnormality of B cell number (HP:0010975)1.72346777
148Abnormal protein glycosylation (HP:0012346)1.71823795
149Abnormal glycosylation (HP:0012345)1.71823795
150Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.71823795
151Abnormal protein N-linked glycosylation (HP:0012347)1.71823795
152Recurrent fungal infections (HP:0002841)1.71351176
153Acute myeloid leukemia (HP:0004808)1.70487615
154Patellar aplasia (HP:0006443)1.69356858
155Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.69295790
156Recurrent viral infections (HP:0004429)1.69289220
157Retinal dysplasia (HP:0007973)1.68990461
158Aplasia/Hypoplasia of the fovea (HP:0008060)1.67477727
159Hypoplasia of the fovea (HP:0007750)1.67477727
160Abnormality of midbrain morphology (HP:0002418)1.67243937
161Molar tooth sign on MRI (HP:0002419)1.67243937
162Impaired proprioception (HP:0010831)1.67179714
163Thickened calvaria (HP:0002684)1.66616116
164Increased serum lactate (HP:0002151)1.65912822
165Hepatic necrosis (HP:0002605)1.64731361
166Broad distal phalanx of finger (HP:0009836)1.64508751
167Aplasia/Hypoplasia of the patella (HP:0006498)1.64307447
168Irregular epiphyses (HP:0010582)1.62789861
169Deep palmar crease (HP:0006191)1.62677725
170Increased serum ferritin (HP:0003281)1.62586112
171Reticulocytosis (HP:0001923)1.61727641
172Amyotrophic lateral sclerosis (HP:0007354)1.59249901
173Small hand (HP:0200055)1.58200310
174Gastrointestinal infarctions (HP:0005244)1.57894549
175Type II lissencephaly (HP:0007260)1.57272998
176Recurrent bacterial skin infections (HP:0005406)1.57203178
177Papilledema (HP:0001085)1.57048315
178Abnormality of the fovea (HP:0000493)1.55659646
179Failure to thrive in infancy (HP:0001531)1.55626830
180Insomnia (HP:0100785)1.55612705
181Abnormality of alanine metabolism (HP:0010916)1.55031699
182Hyperalaninemia (HP:0003348)1.55031699
183Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.55031699
184Cortical visual impairment (HP:0100704)1.54478384
185Tubulointerstitial fibrosis (HP:0005576)1.54319421

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK34.07314739
2MAP3K113.64086281
3LMTK23.59495972
4TXK3.31269295
5STK163.01185461
6CASK2.80119832
7TNIK2.46707511
8ACVR1B2.13317932
9SRPK12.06311891
10BRD42.04113650
11MAP2K31.99557161
12IRAK41.98919524
13ZAK1.96237029
14ICK1.94444626
15CDK81.93705445
16BCKDK1.90371711
17MAP2K71.88892267
18TEC1.87786286
19MAP4K11.85731224
20MAP2K41.78487825
21MAP3K141.72314758
22MARK11.71351108
23MAP3K121.69415446
24ERN11.66721246
25TESK21.66243956
26VRK11.63512480
27PINK11.58820691
28TLK11.53182820
29DYRK21.52419485
30KIT1.51632783
31YES11.51565332
32ADRBK21.51215431
33MAPK121.49727607
34MAP2K21.47670321
35NME21.47243875
36BMPR1B1.45358114
37STK111.44569303
38IRAK31.38753822
39SIK11.34765354
40RPS6KA41.33468454
41SGK21.31330957
42MKNK21.27892899
43SIK21.25896210
44MARK31.25109617
45MAP2K61.24709166
46CCNB11.24439208
47TYK21.24058532
48ATR1.14232883
49NUAK11.13949470
50IKBKE1.13528127
51NLK1.12593943
52CDK31.12258869
53JAK31.11568458
54EIF2AK21.10829702
55EEF2K1.08053664
56MKNK11.06605292
57MST41.05700313
58MINK11.05545558
59TAOK21.04438458
60SYK1.03148210
61BTK1.02466019
62BCR1.00428429
63BUB11.00089668
64MAPK130.99063466
65MATK0.97471917
66PRPF4B0.95933213
67CDK190.95696814
68CSNK1A1L0.94635340
69CSNK1G30.93710278
70MARK20.92741333
71CSNK1G20.92245800
72ERBB30.91168543
73TGFBR10.91024171
74BRSK20.90309446
75BRAF0.89291823
76PIM20.89073900
77CHEK20.88803765
78PRKCQ0.87909679
79ZAP700.87367684
80IKBKB0.86468245
81AKT30.85599421
82ARAF0.82464387
83BMPR20.81736010
84MAP3K60.81115395
85TNK20.80819109
86EIF2AK10.79939426
87PLK40.79767340
88CSNK1G10.79216062
89PRKCZ0.79162653
90EIF2AK30.79130508
91RPS6KA50.79050455
92PRKG20.77867155
93TSSK60.76445845
94STK100.75521049
95LYN0.74107700
96RPS6KA10.73733631
97CSF1R0.73380825
98PRKCI0.72521974
99CDK70.71954647
100TAOK10.70901983
101DAPK20.69636768
102PIK3CG0.69242287
103WEE10.69170326
104RPS6KA20.67883247
105AURKA0.67709859
106DYRK1B0.67367673
107WNK40.67220234
108FLT30.66716152
109CHUK0.65791450
110BRSK10.64206670
111CAMK10.63063809
112LCK0.62820039
113TYRO30.62708478
114BLK0.62521600
115MAP3K50.61808846
116TRIM280.60592191
117MAP3K30.60040574
118PIM10.59784640
119GRK70.59676052
120NTRK20.58990956
121PDK10.58933360
122RPS6KB20.58256399
123SGK30.58009275
124GRK60.57738506
125RIPK40.57662390
126CDK120.56354728
127SMG10.56317403
128TRIB30.55524640
129UHMK10.55388135
130MAP3K90.52842402
131PLK30.52401199
132MAP3K130.51034562
133CLK10.50965658
134NEK60.50066153
135CDC70.50049219
136RAF10.49844056
137WNK10.49423773
138ITK0.49249907
139RPS6KA60.48989251
140TGFBR20.47855763
141SGK2230.47076975
142SGK4940.47076975
143GRK10.45842503
144CAMK40.45451740
145DYRK30.43502526
146DYRK1A0.42965597
147MAP3K40.42289402
148TBK10.42206167
149DAPK10.42165320
150ATM0.41754188
151FES0.41347272
152IRAK20.41103999
153MAPKAPK30.40994063
154RPS6KB10.40892897
155TAOK30.40398535
156IRAK10.39562772
157MAPK70.38687790
158RPS6KC10.38432137

Predicted pathways (KEGG)

RankGene SetZ-score
1Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.88118733
2DNA replication_Homo sapiens_hsa030302.62973367
3Primary immunodeficiency_Homo sapiens_hsa053402.62212660
4Selenocompound metabolism_Homo sapiens_hsa004502.59820377
5Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.52968531
6Homologous recombination_Homo sapiens_hsa034402.45385865
7Fanconi anemia pathway_Homo sapiens_hsa034602.35371421
8Mismatch repair_Homo sapiens_hsa034302.33775441
9Base excision repair_Homo sapiens_hsa034102.23562168
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.20191578
11Basal transcription factors_Homo sapiens_hsa030222.00726069
12RNA polymerase_Homo sapiens_hsa030201.95182677
13Non-homologous end-joining_Homo sapiens_hsa034501.91342825
14RNA degradation_Homo sapiens_hsa030181.84328745
15Pyrimidine metabolism_Homo sapiens_hsa002401.79287410
16Nucleotide excision repair_Homo sapiens_hsa034201.78896571
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.75494784
18NF-kappa B signaling pathway_Homo sapiens_hsa040641.73849003
19Hematopoietic cell lineage_Homo sapiens_hsa046401.73661510
20Spliceosome_Homo sapiens_hsa030401.69623502
21Intestinal immune network for IgA production_Homo sapiens_hsa046721.69474061
22Herpes simplex infection_Homo sapiens_hsa051681.64175385
23Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.57477780
24Measles_Homo sapiens_hsa051621.56919498
25Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.56437718
26Asthma_Homo sapiens_hsa053101.53390532
27VEGF signaling pathway_Homo sapiens_hsa043701.52870450
28Ribosome_Homo sapiens_hsa030101.47760944
29SNARE interactions in vesicular transport_Homo sapiens_hsa041301.44814443
30RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.44516000
31Cell cycle_Homo sapiens_hsa041101.42296933
32Taste transduction_Homo sapiens_hsa047421.36551997
33Regulation of autophagy_Homo sapiens_hsa041401.35206122
34Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.32032054
35Protein export_Homo sapiens_hsa030601.30188229
36Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.27306393
37Purine metabolism_Homo sapiens_hsa002301.20555135
38Proteasome_Homo sapiens_hsa030501.20395416
39Other glycan degradation_Homo sapiens_hsa005111.20014898
40Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.15627774
41Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.12397833
42Lysosome_Homo sapiens_hsa041421.10745784
43Jak-STAT signaling pathway_Homo sapiens_hsa046301.10363003
44Toll-like receptor signaling pathway_Homo sapiens_hsa046201.09695917
45Allograft rejection_Homo sapiens_hsa053301.07124144
46Epstein-Barr virus infection_Homo sapiens_hsa051691.06877898
47Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.06265460
48Influenza A_Homo sapiens_hsa051641.05902194
49Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.05519666
50RNA transport_Homo sapiens_hsa030131.05104884
51p53 signaling pathway_Homo sapiens_hsa041151.02325346
52B cell receptor signaling pathway_Homo sapiens_hsa046621.02007039
53Transcriptional misregulation in cancer_Homo sapiens_hsa052021.00344948
54Rheumatoid arthritis_Homo sapiens_hsa053230.99657774
55Neurotrophin signaling pathway_Homo sapiens_hsa047220.98890043
56Autoimmune thyroid disease_Homo sapiens_hsa053200.97735671
57Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.96836270
58Olfactory transduction_Homo sapiens_hsa047400.94588633
59Leishmaniasis_Homo sapiens_hsa051400.94560419
60Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.93654274
61T cell receptor signaling pathway_Homo sapiens_hsa046600.93223018
62One carbon pool by folate_Homo sapiens_hsa006700.92731771
63Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.92093913
64Graft-versus-host disease_Homo sapiens_hsa053320.90495331
65Oxidative phosphorylation_Homo sapiens_hsa001900.89110823
66mTOR signaling pathway_Homo sapiens_hsa041500.88304536
67Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.88250068
68ErbB signaling pathway_Homo sapiens_hsa040120.87685896
69Collecting duct acid secretion_Homo sapiens_hsa049660.87335616
70Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.86296506
71Alcoholism_Homo sapiens_hsa050340.85028245
72Cyanoamino acid metabolism_Homo sapiens_hsa004600.84115189
73NOD-like receptor signaling pathway_Homo sapiens_hsa046210.83575088
74Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.82375861
75mRNA surveillance pathway_Homo sapiens_hsa030150.81472712
76Antigen processing and presentation_Homo sapiens_hsa046120.81010901
77Nicotine addiction_Homo sapiens_hsa050330.80516764
78Osteoclast differentiation_Homo sapiens_hsa043800.80036347
79Tuberculosis_Homo sapiens_hsa051520.79617119
80Legionellosis_Homo sapiens_hsa051340.78828275
81Hepatitis B_Homo sapiens_hsa051610.76504623
82Long-term depression_Homo sapiens_hsa047300.72471038
83Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.71914737
84Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.71205112
85Type I diabetes mellitus_Homo sapiens_hsa049400.70371395
86Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.69425226
87Circadian rhythm_Homo sapiens_hsa047100.67383332
88Vibrio cholerae infection_Homo sapiens_hsa051100.67141512
89Non-small cell lung cancer_Homo sapiens_hsa052230.65360333
90Sphingolipid metabolism_Homo sapiens_hsa006000.64149119
91Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.63634718
92Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.63529370
93Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.63424707
94HTLV-I infection_Homo sapiens_hsa051660.62074526
95Parkinsons disease_Homo sapiens_hsa050120.60610212
96GABAergic synapse_Homo sapiens_hsa047270.60607196
97Glutamatergic synapse_Homo sapiens_hsa047240.60303515
98Bladder cancer_Homo sapiens_hsa052190.54860957
99Morphine addiction_Homo sapiens_hsa050320.54657876
100Acute myeloid leukemia_Homo sapiens_hsa052210.54305493
101Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.54103656
102Dopaminergic synapse_Homo sapiens_hsa047280.54002883
103Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.53894763
104Synaptic vesicle cycle_Homo sapiens_hsa047210.53448964
105Chronic myeloid leukemia_Homo sapiens_hsa052200.52304290
106Apoptosis_Homo sapiens_hsa042100.51651814
107Chemokine signaling pathway_Homo sapiens_hsa040620.50873259
108Viral carcinogenesis_Homo sapiens_hsa052030.50203847
109TNF signaling pathway_Homo sapiens_hsa046680.48947138
110Colorectal cancer_Homo sapiens_hsa052100.48795741
111Phosphatidylinositol signaling system_Homo sapiens_hsa040700.48757233
112Ether lipid metabolism_Homo sapiens_hsa005650.48712835
113Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.48103549
114N-Glycan biosynthesis_Homo sapiens_hsa005100.48041020
115Phagosome_Homo sapiens_hsa041450.47231251
116Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.45605782
117Alzheimers disease_Homo sapiens_hsa050100.45466468
118Systemic lupus erythematosus_Homo sapiens_hsa053220.45340156
119Shigellosis_Homo sapiens_hsa051310.45215684
120Salmonella infection_Homo sapiens_hsa051320.44868351
121MAPK signaling pathway_Homo sapiens_hsa040100.44748967
122Choline metabolism in cancer_Homo sapiens_hsa052310.44677167
123Phototransduction_Homo sapiens_hsa047440.44175088
124Hepatitis C_Homo sapiens_hsa051600.40576552
125Toxoplasmosis_Homo sapiens_hsa051450.37564237
126Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.37352569
127Mineral absorption_Homo sapiens_hsa049780.34945189
128Pancreatic cancer_Homo sapiens_hsa052120.32919077
129Renin-angiotensin system_Homo sapiens_hsa046140.31794555
130Inositol phosphate metabolism_Homo sapiens_hsa005620.30115671
131Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.29798100
132Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.28850613
133Sulfur relay system_Homo sapiens_hsa041220.28448419
134Serotonergic synapse_Homo sapiens_hsa047260.28301984
135Notch signaling pathway_Homo sapiens_hsa043300.27856375

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