VPS35

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)7.59809561
2COPI coating of Golgi vesicle (GO:0048205)7.59809561
3ER overload response (GO:0006983)4.71365293
4retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.68762621
5transferrin transport (GO:0033572)4.53075333
6trivalent inorganic cation transport (GO:0072512)4.40474099
7ferric iron transport (GO:0015682)4.40474099
8vesicle coating (GO:0006901)4.10075150
9response to hepatocyte growth factor (GO:0035728)4.06090743
10cellular response to hepatocyte growth factor stimulus (GO:0035729)4.06090743
11DNA double-strand break processing (GO:0000729)3.93282191
12regulation of synaptic vesicle exocytosis (GO:2000300)3.78845990
13phagosome maturation (GO:0090382)3.78815652
14protein deneddylation (GO:0000338)3.75829454
15protein maturation by protein folding (GO:0022417)3.70571522
16energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.66840405
17ATP hydrolysis coupled proton transport (GO:0015991)3.66840405
18signal peptide processing (GO:0006465)3.64186077
19negative regulation of neurotransmitter secretion (GO:0046929)3.57804360
20ribonucleoprotein complex disassembly (GO:0032988)3.51340521
21mitotic sister chromatid cohesion (GO:0007064)3.48773528
22resolution of meiotic recombination intermediates (GO:0000712)3.44046937
23COPII vesicle coating (GO:0048208)3.38792671
24vesicle transport along microtubule (GO:0047496)3.36541313
25regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.33745587
26non-recombinational repair (GO:0000726)3.31647788
27double-strand break repair via nonhomologous end joining (GO:0006303)3.31647788
28proteasome assembly (GO:0043248)3.28908018
29organelle disassembly (GO:1903008)3.26960662
30regulation of DNA endoreduplication (GO:0032875)3.22351129
31synapsis (GO:0007129)3.20971042
32centriole replication (GO:0007099)3.20652268
33intraciliary transport (GO:0042073)3.20437101
34establishment of integrated proviral latency (GO:0075713)3.17639078
35histone H2A acetylation (GO:0043968)3.14826815
36organelle transport along microtubule (GO:0072384)3.14245999
37CENP-A containing nucleosome assembly (GO:0034080)3.13625664
38insulin secretion (GO:0030073)3.11352953
39iron ion transport (GO:0006826)3.11271177
40DNA ligation (GO:0006266)3.09659991
41protein heterotetramerization (GO:0051290)3.08283174
42pH reduction (GO:0045851)3.08200096
43regulation of short-term neuronal synaptic plasticity (GO:0048172)3.06284612
44synaptic vesicle exocytosis (GO:0016079)3.06205877
45negative regulation of protein localization to plasma membrane (GO:1903077)3.05845280
46chromatin remodeling at centromere (GO:0031055)3.03636567
47inositol phosphate catabolic process (GO:0071545)3.02604610
48intra-Golgi vesicle-mediated transport (GO:0006891)3.02163061
49vesicle docking (GO:0048278)3.00513959
50negative regulation of neurotransmitter transport (GO:0051589)2.99968119
51microtubule depolymerization (GO:0007019)2.95604420
52regulation of sister chromatid cohesion (GO:0007063)2.95024593
53sequestering of metal ion (GO:0051238)2.89495341
54keratinocyte development (GO:0003334)2.89049358
55maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.88960790
56positive regulation of actin filament depolymerization (GO:0030836)2.88032995
57intracellular pH reduction (GO:0051452)2.85869495
58cellular response to vitamin D (GO:0071305)2.85135219
59regulation of centriole replication (GO:0046599)2.82974692
60sister chromatid cohesion (GO:0007062)2.82335163
61anterograde synaptic vesicle transport (GO:0048490)2.81589880
62peptide hormone processing (GO:0016486)2.79552339
63nuclear pore complex assembly (GO:0051292)2.78165456
64metaphase plate congression (GO:0051310)2.77000825
65glutamate secretion (GO:0014047)2.76743868
66regulation of synaptic vesicle transport (GO:1902803)2.74325405
67cellular response to vitamin (GO:0071295)2.72772302
68synaptic vesicle maturation (GO:0016188)2.72739226
69vesicle docking involved in exocytosis (GO:0006904)2.72253207
70antigen processing and presentation of peptide antigen via MHC class II (GO:0002495)2.71591704
71antigen processing and presentation of peptide or polysaccharide antigen via MHC class II (GO:0002502.71591704
72inositol phosphate dephosphorylation (GO:0046855)2.71383228
73phosphorylated carbohydrate dephosphorylation (GO:0046838)2.71383228
74antigen processing and presentation of exogenous peptide antigen via MHC class II (GO:0019886)2.71245143
75ganglion development (GO:0061548)2.70786696
76acrosome assembly (GO:0001675)2.70695003
77histone exchange (GO:0043486)2.70498658
78seminiferous tubule development (GO:0072520)2.70213192
79response to lipoprotein particle (GO:0055094)2.69658577
80pyrimidine nucleobase catabolic process (GO:0006208)2.67379001
81cullin deneddylation (GO:0010388)2.66911098
82protein K11-linked ubiquitination (GO:0070979)2.66215134
83response to redox state (GO:0051775)2.65916936
84epithelial cilium movement (GO:0003351)2.63793586
85ER to Golgi vesicle-mediated transport (GO:0006888)2.63758445
86response to X-ray (GO:0010165)2.61514454
87mitotic metaphase plate congression (GO:0007080)2.61469987
88synaptic vesicle docking involved in exocytosis (GO:0016081)2.61399370
89regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.60657190
90presynaptic membrane assembly (GO:0097105)2.59210777
91Golgi vesicle transport (GO:0048193)2.58011923
92activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.56890117
93nucleobase catabolic process (GO:0046113)2.55966022
94regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.55460525
95negative regulation of exocytosis (GO:0045920)2.55247090
96protein prenylation (GO:0018342)2.54261870
97prenylation (GO:0097354)2.54261870
98peroxisome fission (GO:0016559)2.54233276
99eosinophil chemotaxis (GO:0048245)2.52906690
100spindle assembly involved in mitosis (GO:0090307)2.52317316
101negative regulation of DNA-dependent DNA replication (GO:2000104)2.51914136
102tRNA aminoacylation for protein translation (GO:0006418)2.51782174
103amino acid activation (GO:0043038)2.51681812
104tRNA aminoacylation (GO:0043039)2.51681812
105spindle checkpoint (GO:0031577)2.51458383
106long-chain fatty acid biosynthetic process (GO:0042759)2.50851999
107positive regulation of male gonad development (GO:2000020)2.49709079
108establishment of melanosome localization (GO:0032401)2.49486494
109DNA catabolic process, exonucleolytic (GO:0000738)2.47768408
110meiotic chromosome segregation (GO:0045132)2.45958487
111negative regulation of DNA recombination (GO:0045910)2.45609518
112anterograde axon cargo transport (GO:0008089)2.45023629
113endoplasmic reticulum unfolded protein response (GO:0030968)2.44145843
114positive regulation of nuclease activity (GO:0032075)2.43411993
115cellular response to unfolded protein (GO:0034620)2.42475070
116mitotic spindle checkpoint (GO:0071174)2.42447811
117regulation of Golgi to plasma membrane protein transport (GO:0042996)2.42259986
118cilium morphogenesis (GO:0060271)2.41849293
119cilium assembly (GO:0042384)2.41751236
120prostate gland growth (GO:0060736)2.41547758
121detection of calcium ion (GO:0005513)2.41384492
122Rac protein signal transduction (GO:0016601)2.41168755
123peptidyl-cysteine modification (GO:0018198)2.41006787
124cilium organization (GO:0044782)2.40890111
125cellular response to topologically incorrect protein (GO:0035967)2.40634895
126clathrin coat assembly (GO:0048268)2.39516457
127regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.38400402
128establishment of viral latency (GO:0019043)2.38275184
129regulation of protein localization to plasma membrane (GO:1903076)2.37781411
130ER-nucleus signaling pathway (GO:0006984)2.37775722
131mitotic spindle organization (GO:0007052)2.37703946
132cerebellar Purkinje cell layer development (GO:0021680)2.37134012
133regulation of cilium movement (GO:0003352)2.36830103
134DNA replication-independent nucleosome organization (GO:0034724)2.36601950
135DNA replication-independent nucleosome assembly (GO:0006336)2.36601950
136proline transport (GO:0015824)2.36263843
137negative regulation of mast cell activation (GO:0033004)2.36133280
138tricarboxylic acid cycle (GO:0006099)2.34902292
139apical protein localization (GO:0045176)2.34838189
140positive regulation of exocytosis (GO:0045921)2.34116130
141positive regulation of mitotic sister chromatid separation (GO:1901970)2.34040634
142positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.34040634
143positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.34040634
144establishment of pigment granule localization (GO:0051905)2.33796157
145protein localization to cilium (GO:0061512)2.33350499
146establishment of vesicle localization (GO:0051650)2.32667434
147kinetochore organization (GO:0051383)2.32018446
148regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.31939270
149myelin assembly (GO:0032288)2.31823117
150urinary tract smooth muscle contraction (GO:0014848)2.31425382
151nuclear pore organization (GO:0006999)2.31377257
152presynaptic membrane organization (GO:0097090)2.30893529
153regulation of cAMP-dependent protein kinase activity (GO:2000479)2.30346607
154regulation of type B pancreatic cell apoptotic process (GO:2000674)2.30103874
155replication fork processing (GO:0031297)2.30008029
156sister chromatid segregation (GO:0000819)2.29870347
157inner ear receptor cell development (GO:0060119)2.29273158
158melanosome transport (GO:0032402)2.28823054
159negative regulation of membrane potential (GO:0045837)2.28747083
160regulation of insulin secretion (GO:0050796)2.28036995
161protein localization to kinetochore (GO:0034501)2.27764104
162cholesterol biosynthetic process (GO:0006695)2.27644766
163regulation of nuclease activity (GO:0032069)2.27494072
164endocrine pancreas development (GO:0031018)2.27469938
165positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.27271553
166long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.27206123
167postreplication repair (GO:0006301)2.26505494
168eosinophil migration (GO:0072677)2.26254910
169regulation of chromosome segregation (GO:0051983)2.26230770
170positive regulation of mitochondrial fission (GO:0090141)2.26099597
171nucleotide transmembrane transport (GO:1901679)2.25881188
172anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.25608233
173regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.24867161
174regulation of mitotic spindle checkpoint (GO:1903504)2.24867161
175misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.24549121
176cardiac right ventricle morphogenesis (GO:0003215)2.24489898
177L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.24170068
178regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.23641994
179platelet dense granule organization (GO:0060155)2.23472565
180macroautophagy (GO:0016236)2.23413873
181epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.23286645
182post-Golgi vesicle-mediated transport (GO:0006892)2.22712515
183nucleotide-excision repair, DNA gap filling (GO:0006297)2.22450224
184branched-chain amino acid catabolic process (GO:0009083)2.21849773
185regulation of mitotic metaphase/anaphase transition (GO:0030071)2.21200176
186regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.21200176
187establishment of chromosome localization (GO:0051303)2.21172888
188protein K6-linked ubiquitination (GO:0085020)2.20587489
189neural tube formation (GO:0001841)2.20152760
190limb bud formation (GO:0060174)2.19928431
191microtubule polymerization or depolymerization (GO:0031109)2.19044938
192regulation of spindle organization (GO:0090224)2.18999924
193attachment of spindle microtubules to kinetochore (GO:0008608)2.18977181
194regulation of acyl-CoA biosynthetic process (GO:0050812)2.18555359
195lipopolysaccharide biosynthetic process (GO:0009103)2.17086426

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.67612293
2GBX2_23144817_ChIP-Seq_PC3_Human4.20110429
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.01426468
4POU3F2_20337985_ChIP-ChIP_501MEL_Human2.99340049
5WT1_19549856_ChIP-ChIP_CCG9911_Human2.59504960
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.59199049
7ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.44995793
8RBPJ_22232070_ChIP-Seq_NCS_Mouse2.37561238
9CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.37520454
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.36959500
11FUS_26573619_Chip-Seq_HEK293_Human2.34763992
12OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.30862892
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.25716030
14TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.22740521
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.16236402
16SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.15614881
17AR_21909140_ChIP-Seq_LNCAP_Human2.06513355
18* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.02659863
19EST1_17652178_ChIP-ChIP_JURKAT_Human2.02587109
20AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.99021967
21IGF1R_20145208_ChIP-Seq_DFB_Human1.93253680
22CTBP2_25329375_ChIP-Seq_LNCAP_Human1.92784260
23E2F7_22180533_ChIP-Seq_HELA_Human1.91388387
24P300_19829295_ChIP-Seq_ESCs_Human1.85800482
25PIAS1_25552417_ChIP-Seq_VCAP_Human1.84550842
26SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.84382554
27TAF15_26573619_Chip-Seq_HEK293_Human1.81562403
28FLI1_27457419_Chip-Seq_LIVER_Mouse1.81025778
29VDR_22108803_ChIP-Seq_LS180_Human1.80754801
30STAT3_23295773_ChIP-Seq_U87_Human1.80444831
31PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.80401490
32ER_23166858_ChIP-Seq_MCF-7_Human1.76259066
33SMAD4_21799915_ChIP-Seq_A2780_Human1.76068490
34PCGF2_27294783_Chip-Seq_ESCs_Mouse1.75484003
35NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.74385753
36NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.73379081
37NRF2_20460467_ChIP-Seq_MEFs_Mouse1.73379081
38* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.72161184
39EWS_26573619_Chip-Seq_HEK293_Human1.70837526
40MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.67138367
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.64955761
42GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.64587737
43NANOG_18555785_Chip-Seq_ESCs_Mouse1.59566397
44TOP2B_26459242_ChIP-Seq_MCF-7_Human1.58426295
45TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.56674326
46HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.55894736
47PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.54677868
48CMYC_18555785_Chip-Seq_ESCs_Mouse1.51100633
49GATA1_22025678_ChIP-Seq_K562_Human1.50412693
50* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.49624018
51CREB1_15753290_ChIP-ChIP_HEK293T_Human1.49561981
52SMAD3_21741376_ChIP-Seq_EPCs_Human1.48867394
53ELK1_19687146_ChIP-ChIP_HELA_Human1.47329077
54* TCF4_23295773_ChIP-Seq_U87_Human1.46171013
55BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.45905593
56EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.44053661
57CTBP1_25329375_ChIP-Seq_LNCAP_Human1.43897535
58RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.43450503
59P53_22387025_ChIP-Seq_ESCs_Mouse1.42671248
60JUN_21703547_ChIP-Seq_K562_Human1.42217375
61E2F1_18555785_Chip-Seq_ESCs_Mouse1.41146651
62GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40127455
63SUZ12_18555785_Chip-Seq_ESCs_Mouse1.39400578
64SOX2_21211035_ChIP-Seq_LN229_Gbm1.38980760
65STAT3_18555785_Chip-Seq_ESCs_Mouse1.37847945
66SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37318094
67VDR_23849224_ChIP-Seq_CD4+_Human1.35121957
68NR3C1_23031785_ChIP-Seq_PC12_Mouse1.34691441
69ZNF274_21170338_ChIP-Seq_K562_Hela1.32121007
70TP53_18474530_ChIP-ChIP_U2OS_Human1.31450717
71PCGF2_27294783_Chip-Seq_NPCs_Mouse1.30258780
72P300_18555785_Chip-Seq_ESCs_Mouse1.28512145
73REST_19997604_ChIP-ChIP_NEURONS_Mouse1.28162203
74SOX2_18555785_Chip-Seq_ESCs_Mouse1.27828573
75CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.27622489
76HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.26994772
77IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.25098827
78CBP_20019798_ChIP-Seq_JUKART_Human1.25098827
79CDX2_19796622_ChIP-Seq_MESCs_Mouse1.24143425
80SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.22875372
81PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22248162
82SUZ12_27294783_Chip-Seq_NPCs_Mouse1.21253125
83PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.20531358
84FOXM1_26456572_ChIP-Seq_MCF-7_Human1.20240022
85NMYC_18555785_Chip-Seq_ESCs_Mouse1.20157206
86EZH2_27294783_Chip-Seq_NPCs_Mouse1.19189518
87UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.18286389
88KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18153421
89PADI4_21655091_ChIP-ChIP_MCF-7_Human1.17223171
90AR_25329375_ChIP-Seq_VCAP_Human1.15994802
91YAP1_20516196_ChIP-Seq_MESCs_Mouse1.15773089
92TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.15523186
93FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.15277813
94MYC_18940864_ChIP-ChIP_HL60_Human1.14226142
95* TFEB_21752829_ChIP-Seq_HELA_Human1.13429648
96ZNF217_24962896_ChIP-Seq_MCF-7_Human1.13087824
97Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.13049253
98PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.11203564
99FLI1_21867929_ChIP-Seq_TH2_Mouse1.10192754
100YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.09065162
101STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.08756276
102FOXM1_23109430_ChIP-Seq_U2OS_Human1.07900148
103EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.06674079
104RUNX2_22187159_ChIP-Seq_PCA_Human1.06445441
105SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.05740701
106DCP1A_22483619_ChIP-Seq_HELA_Human1.05056621
107BCAT_22108803_ChIP-Seq_LS180_Human1.04912322
108SALL4_18804426_ChIP-ChIP_XEN_Mouse1.04433602
109MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.03407840
110* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.03099616
111REST_21632747_ChIP-Seq_MESCs_Mouse1.02772790
112TRIM28_21343339_ChIP-Seq_HEK293_Human1.02012146
113SRF_21415370_ChIP-Seq_HL-1_Mouse1.01986313
114ETS1_20019798_ChIP-Seq_JURKAT_Human1.01917141
115FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.01785736
116CRX_20693478_ChIP-Seq_RETINA_Mouse1.01031416
117PU1_27457419_Chip-Seq_LIVER_Mouse1.00990229
118OCT4_18555785_Chip-Seq_ESCs_Mouse1.00837849
119NFE2_27457419_Chip-Seq_LIVER_Mouse1.00726317
120BMI1_23680149_ChIP-Seq_NPCS_Mouse1.00641296
121* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.00548732
122MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.00003084
123CTCF_18555785_Chip-Seq_ESCs_Mouse0.99275680
124KLF4_18555785_Chip-Seq_ESCs_Mouse0.99259165
125KDM2B_26808549_Chip-Seq_REH_Human0.98742278
126NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.98501698
127RUNX1_27457419_Chip-Seq_LIVER_Mouse0.98317240
128TAL1_26923725_Chip-Seq_HPCs_Mouse0.98052137
129CDX2_22108803_ChIP-Seq_LS180_Human0.97734285
130MYCN_18555785_ChIP-Seq_MESCs_Mouse0.97685634
131SMAD1_18555785_Chip-Seq_ESCs_Mouse0.97511608
132CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97254291
133NANOG_19829295_ChIP-Seq_ESCs_Human0.96716005
134SOX2_19829295_ChIP-Seq_ESCs_Human0.96716005
135SOX17_20123909_ChIP-Seq_XEN_Mouse0.96455636
136TCF4_22108803_ChIP-Seq_LS180_Human0.96299726
137RNF2_27304074_Chip-Seq_NSC_Mouse0.95964329
138KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.94884768

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010386_abnormal_urinary_bladder3.64786908
2MP0009780_abnormal_chondrocyte_physiolo3.62572135
3MP0003283_abnormal_digestive_organ3.30754167
4MP0008877_abnormal_DNA_methylation3.29460802
5MP0002877_abnormal_melanocyte_morpholog3.15231666
6MP0000013_abnormal_adipose_tissue3.03435380
7MP0003195_calcinosis2.87700225
8MP0004270_analgesia2.83406831
9MP0002102_abnormal_ear_morphology2.82816479
10MP0008438_abnormal_cutaneous_collagen2.82400752
11MP0003183_abnormal_peptide_metabolism2.81833192
12MP0008058_abnormal_DNA_repair2.64131242
13MP0005058_abnormal_lysosome_morphology2.61008474
14MP0000569_abnormal_digit_pigmentation2.58132175
15MP0010094_abnormal_chromosome_stability2.28871302
16MP0005171_absent_coat_pigmentation2.25878819
17MP0004043_abnormal_pH_regulation2.12284843
18MP0006054_spinal_hemorrhage2.10969477
19MP0001188_hyperpigmentation2.06008915
20MP0002734_abnormal_mechanical_nocicepti2.03301397
21MP0002638_abnormal_pupillary_reflex2.01271670
22MP0002735_abnormal_chemical_nociception1.97420009
23MP0003172_abnormal_lysosome_physiology1.96724214
24MP0005623_abnormal_meninges_morphology1.89870312
25MP0004859_abnormal_synaptic_plasticity1.84769216
26MP0005645_abnormal_hypothalamus_physiol1.83327555
27MP0003122_maternal_imprinting1.81760873
28MP0002876_abnormal_thyroid_physiology1.69325946
29MP0002909_abnormal_adrenal_gland1.66685295
30MP0001984_abnormal_olfaction1.60310967
31MP0001986_abnormal_taste_sensitivity1.59825001
32MP0008057_abnormal_DNA_replication1.59583102
33MP0003787_abnormal_imprinting1.58929213
34MP0004957_abnormal_blastocyst_morpholog1.58404507
35MP0005646_abnormal_pituitary_gland1.57366630
36MP0001299_abnormal_eye_distance/1.57201569
37MP0008260_abnormal_autophagy1.56033992
38MP0010307_abnormal_tumor_latency1.55941016
39MP0002896_abnormal_bone_mineralization1.53974777
40MP0003634_abnormal_glial_cell1.52581486
41MP0002938_white_spotting1.51471988
42MP0000383_abnormal_hair_follicle1.49075352
43MP0002693_abnormal_pancreas_physiology1.45012518
44MP0002736_abnormal_nociception_after1.43690646
45MP0006072_abnormal_retinal_apoptosis1.43065263
46MP0003635_abnormal_synaptic_transmissio1.42962563
47MP0003693_abnormal_embryo_hatching1.42503908
48MP0000647_abnormal_sebaceous_gland1.40878828
49MP0009046_muscle_twitch1.40870449
50MP0005174_abnormal_tail_pigmentation1.39357392
51MP0008932_abnormal_embryonic_tissue1.36605208
52MP0002064_seizures1.36490513
53MP0002063_abnormal_learning/memory/cond1.36397639
54MP0008995_early_reproductive_senescence1.34070323
55MP0003567_abnormal_fetal_cardiomyocyte1.33882905
56MP0000920_abnormal_myelination1.32715597
57MP0003786_premature_aging1.29910486
58MP0003011_delayed_dark_adaptation1.29696674
59MP0004215_abnormal_myocardial_fiber1.28927256
60MP0003690_abnormal_glial_cell1.28830414
61MP0003632_abnormal_nervous_system1.28361603
62MP0002733_abnormal_thermal_nociception1.27737280
63MP0003718_maternal_effect1.27579111
64MP0001968_abnormal_touch/_nociception1.27259688
65MP0003315_abnormal_perineum_morphology1.25750905
66MP0000003_abnormal_adipose_tissue1.24782684
67MP0004147_increased_porphyrin_level1.24313751
68MP0003111_abnormal_nucleus_morphology1.24199380
69MP0003880_abnormal_central_pattern1.22095694
70MP0001944_abnormal_pancreas_morphology1.21865529
71MP0003937_abnormal_limbs/digits/tail_de1.21213486
72MP0001177_atelectasis1.20734886
73MP0004811_abnormal_neuron_physiology1.19894019
74MP0002572_abnormal_emotion/affect_behav1.16870975
75MP0008007_abnormal_cellular_replicative1.16558015
76MP0003123_paternal_imprinting1.15739217
77MP0000015_abnormal_ear_pigmentation1.14750072
78MP0003950_abnormal_plasma_membrane1.14540429
79MP0003806_abnormal_nucleotide_metabolis1.13606400
80MP0005275_abnormal_skin_tensile1.13272627
81MP0000537_abnormal_urethra_morphology1.10737991
82MP0008789_abnormal_olfactory_epithelium1.10162268
83MP0005551_abnormal_eye_electrophysiolog1.09969118
84MP0005085_abnormal_gallbladder_physiolo1.09301715
85MP0002233_abnormal_nose_morphology1.09230202
86MP0005084_abnormal_gallbladder_morpholo1.07489827
87MP0006035_abnormal_mitochondrial_morpho1.06557242
88MP0003121_genomic_imprinting1.05920036
89MP0009745_abnormal_behavioral_response1.05502826
90MP0005386_behavior/neurological_phenoty1.05495365
91MP0004924_abnormal_behavior1.05495365
92MP0002229_neurodegeneration1.05312813
93MP0002272_abnormal_nervous_system1.04918955
94MP0001529_abnormal_vocalization1.04736079
95MP0001440_abnormal_grooming_behavior1.04659524
96MP0003329_amyloid_beta_deposits1.03464989
97MP0005503_abnormal_tendon_morphology1.03110476
98MP0001970_abnormal_pain_threshold1.02141204
99MP0002067_abnormal_sensory_capabilities1.01575168
100MP0005253_abnormal_eye_physiology1.01118880
101MP0001293_anophthalmia1.00003137
102MP0002160_abnormal_reproductive_system0.99717670
103MP0000955_abnormal_spinal_cord0.99521338
104MP0009697_abnormal_copulation0.98831681
105MP0002234_abnormal_pharynx_morphology0.98380490
106MP0005248_abnormal_Harderian_gland0.98001265
107MP0002090_abnormal_vision0.97470266
108MP0003631_nervous_system_phenotype0.97425683
109MP0003077_abnormal_cell_cycle0.96771932
110MP0001661_extended_life_span0.96325017
111MP0005379_endocrine/exocrine_gland_phen0.96238126
112MP0000427_abnormal_hair_cycle0.96160324
113MP0000604_amyloidosis0.95730547
114MP0000358_abnormal_cell_content/0.95430477
115MP0002928_abnormal_bile_duct0.93947578
116MP0002084_abnormal_developmental_patter0.93042613
117MP0002822_catalepsy0.92903623
118MP0002095_abnormal_skin_pigmentation0.92570425
119MP0001929_abnormal_gametogenesis0.92301390
120MP0003943_abnormal_hepatobiliary_system0.92150928
121MP0003633_abnormal_nervous_system0.91127981
122MP0001542_abnormal_bone_strength0.91125414
123MP0006276_abnormal_autonomic_nervous0.91069749
124MP0000639_abnormal_adrenal_gland0.90314423
125MP0001764_abnormal_homeostasis0.89802488
126MP0002210_abnormal_sex_determination0.89602219
127MP0003890_abnormal_embryonic-extraembry0.88415526
128MP0010352_gastrointestinal_tract_polyps0.88176951
129MP0005499_abnormal_olfactory_system0.87930641
130MP0005394_taste/olfaction_phenotype0.87930641
131MP0004885_abnormal_endolymph0.87514575
132MP0002078_abnormal_glucose_homeostasis0.86659474
133MP0005391_vision/eye_phenotype0.86070113
134MP0000778_abnormal_nervous_system0.85831845
135MP0000372_irregular_coat_pigmentation0.85534192
136MP0001324_abnormal_eye_pigmentation0.85146622
137MP0000681_abnormal_thyroid_gland0.84987892
138MP0003221_abnormal_cardiomyocyte_apopto0.83825419
139MP0003941_abnormal_skin_development0.83538801
140MP0005367_renal/urinary_system_phenotyp0.82831697
141MP0000516_abnormal_urinary_system0.82831697
142MP0005257_abnormal_intraocular_pressure0.82455237
143MP0000653_abnormal_sex_gland0.81946974
144MP0001145_abnormal_male_reproductive0.81550236
145MP0003755_abnormal_palate_morphology0.79762487
146MP0002295_abnormal_pulmonary_circulatio0.78350177
147MP0005187_abnormal_penis_morphology0.78274414
148MP0001286_abnormal_eye_development0.77743948
149MP0002882_abnormal_neuron_morphology0.77131448
150MP0005075_abnormal_melanosome_morpholog0.76360269
151MP0010234_abnormal_vibrissa_follicle0.76045585
152MP0001727_abnormal_embryo_implantation0.75954160
153MP0003879_abnormal_hair_cell0.75526278
154MP0002066_abnormal_motor_capabilities/c0.74731141
155MP0002184_abnormal_innervation0.74582232
156MP0003119_abnormal_digestive_system0.73983976
157MP0010678_abnormal_skin_adnexa0.73756419
158MP0008875_abnormal_xenobiotic_pharmacok0.73382253
159MP0001697_abnormal_embryo_size0.72108915
160MP0001486_abnormal_startle_reflex0.71786303
161MP0002751_abnormal_autonomic_nervous0.70867493
162MP0004272_abnormal_basement_membrane0.69300614
163MP0002168_other_aberrant_phenotype0.69068250
164MP0008004_abnormal_stomach_pH0.67796271
165MP0005408_hypopigmentation0.67515732
166MP0004134_abnormal_chest_morphology0.67482400

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)4.28046171
2Hypoglycemic seizures (HP:0002173)3.51189869
3Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.48879698
4Increased cerebral lipofuscin (HP:0011813)3.38135858
5Termporal pattern (HP:0011008)3.24728812
6Insidious onset (HP:0003587)3.24728812
7Increased neuronal autofluorescent lipopigment (HP:0002074)3.21034425
8True hermaphroditism (HP:0010459)3.11068118
9Pheochromocytoma (HP:0002666)3.07104761
10Hyperinsulinemic hypoglycemia (HP:0000825)3.06362267
11Symptomatic seizures (HP:0011145)3.02170739
12Epileptiform EEG discharges (HP:0011182)2.86827487
13Neuroendocrine neoplasm (HP:0100634)2.86498025
14Atonic seizures (HP:0010819)2.81986272
15EEG with generalized epileptiform discharges (HP:0011198)2.80935213
16Hypsarrhythmia (HP:0002521)2.75946047
17Congenital primary aphakia (HP:0007707)2.71406764
18Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.67435202
19Degeneration of the lateral corticospinal tracts (HP:0002314)2.67435202
20Short tibia (HP:0005736)2.67250010
21Menstrual irregularities (HP:0000858)2.65667456
22Abnormality of the labia minora (HP:0012880)2.64674834
23Dysostosis multiplex (HP:0000943)2.62877683
24Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.61480406
25Thyroid carcinoma (HP:0002890)2.59175359
26Abnormality of midbrain morphology (HP:0002418)2.59039241
27Molar tooth sign on MRI (HP:0002419)2.59039241
28Amyotrophic lateral sclerosis (HP:0007354)2.57039979
29Epileptic encephalopathy (HP:0200134)2.55688996
30Autoamputation (HP:0001218)2.53747613
31Abnormal lung lobation (HP:0002101)2.53524638
32Abnormality of the anterior horn cell (HP:0006802)2.52903912
33Degeneration of anterior horn cells (HP:0002398)2.52903912
34Pancreatic fibrosis (HP:0100732)2.50825571
35Atrophy/Degeneration involving motor neurons (HP:0007373)2.49623630
36Abnormality of liposaccharide metabolism (HP:0010968)2.49075419
37Abnormality of glycosphingolipid metabolism (HP:0004343)2.49075419
38Abnormality of glycolipid metabolism (HP:0010969)2.49075419
39Genital tract atresia (HP:0001827)2.47767563
40Aplasia/Hypoplasia of the tibia (HP:0005772)2.47435149
41Pancreatic islet-cell hyperplasia (HP:0004510)2.45349978
42Insulin-resistant diabetes mellitus (HP:0000831)2.44689937
43Hyperglycemia (HP:0003074)2.43099653
44Abnormality of glycolysis (HP:0004366)2.42333974
45Increased serum pyruvate (HP:0003542)2.42333974
46Hypothermia (HP:0002045)2.40060087
47Agnosia (HP:0010524)2.39104860
48Tubulointerstitial nephritis (HP:0001970)2.36973761
49Abnormality of chromosome stability (HP:0003220)2.36162965
50Pancreatic cysts (HP:0001737)2.33401001
51Chronic hepatic failure (HP:0100626)2.29242748
52Vaginal atresia (HP:0000148)2.27846917
53Papilledema (HP:0001085)2.26895741
54Abnormality of the corticospinal tract (HP:0002492)2.23618589
55Renal cortical cysts (HP:0000803)2.21762008
56Generalized tonic-clonic seizures (HP:0002069)2.21491021
57Male pseudohermaphroditism (HP:0000037)2.19498404
58Cortical dysplasia (HP:0002539)2.18709593
59Abnormality of the lower motor neuron (HP:0002366)2.15367592
60Cerebral inclusion bodies (HP:0100314)2.14417566
61Abnormality of methionine metabolism (HP:0010901)2.14189668
62Disinhibition (HP:0000734)2.12645747
63Chromsome breakage (HP:0040012)2.10810698
64Shoulder girdle muscle weakness (HP:0003547)2.08557751
65Mucopolysacchariduria (HP:0008155)2.07589102
66Urinary glycosaminoglycan excretion (HP:0003541)2.07589102
67Ependymoma (HP:0002888)2.07306054
68Gonadotropin excess (HP:0000837)2.06191331
69Upper limb muscle weakness (HP:0003484)2.04830068
70Dysautonomia (HP:0002459)2.04720318
71Hypoglycemic coma (HP:0001325)2.03903626
72Osteomalacia (HP:0002749)2.03719084
73Neurofibrillary tangles (HP:0002185)2.02831689
74Spinal muscular atrophy (HP:0007269)2.01588609
75Bifid tongue (HP:0010297)2.01456881
76Aplasia/Hypoplasia of the tongue (HP:0010295)2.00969978
77Abnormality of aspartate family amino acid metabolism (HP:0010899)2.00771477
78Disproportionate short-trunk short stature (HP:0003521)1.97715748
79Medulloblastoma (HP:0002885)1.96740478
80Nephronophthisis (HP:0000090)1.95468896
81Delayed gross motor development (HP:0002194)1.94992764
82Gonadal dysgenesis (HP:0000133)1.94855284
83Supranuclear gaze palsy (HP:0000605)1.93121027
84* Akinesia (HP:0002304)1.92398369
85Abnormality of glycosaminoglycan metabolism (HP:0004371)1.92098389
86Abnormality of mucopolysaccharide metabolism (HP:0011020)1.92098389
87Abnormality of polysaccharide metabolism (HP:0011012)1.92098389
88Meckel diverticulum (HP:0002245)1.91336059
89Neoplasm of the peripheral nervous system (HP:0100007)1.90578650
90Papillary thyroid carcinoma (HP:0002895)1.90560586
91Relative macrocephaly (HP:0004482)1.89508451
92Heterochromia iridis (HP:0001100)1.89415399
93Glioma (HP:0009733)1.89362989
94Aplasia/Hypoplasia of the uvula (HP:0010293)1.87167499
95Postnatal microcephaly (HP:0005484)1.85741989
96Chromosomal breakage induced by crosslinking agents (HP:0003221)1.85115255
97Nephroblastoma (Wilms tumor) (HP:0002667)1.84541358
98Abnormality of the pancreatic islet cells (HP:0006476)1.84457516
99Abnormality of endocrine pancreas physiology (HP:0012093)1.84457516
100Ovarian neoplasm (HP:0100615)1.84265143
101Abnormality of the renal medulla (HP:0100957)1.84038235
102Vacuolated lymphocytes (HP:0001922)1.83856163
103Agitation (HP:0000713)1.83618160
104Abnormal biliary tract morphology (HP:0012440)1.83517482
105Dialeptic seizures (HP:0011146)1.83218697
106Sensory axonal neuropathy (HP:0003390)1.82833291
107Narrow forehead (HP:0000341)1.81702966
108Abnormality of the ileum (HP:0001549)1.80916519
109Absence seizures (HP:0002121)1.80767075
110Truncal ataxia (HP:0002078)1.80125290
111Colon cancer (HP:0003003)1.79540877
112Embryonal renal neoplasm (HP:0011794)1.79243339
113Spastic gait (HP:0002064)1.79131675
114Gait imbalance (HP:0002141)1.78905242
115Lower limb muscle weakness (HP:0007340)1.78843678
116Postaxial foot polydactyly (HP:0001830)1.78096979
117Muscular hypotonia of the trunk (HP:0008936)1.77439348
118Postaxial hand polydactyly (HP:0001162)1.77281165
119Rhinitis (HP:0012384)1.77184726
120Small intestinal stenosis (HP:0012848)1.75717011
121Duodenal stenosis (HP:0100867)1.75717011
122Retinal dysplasia (HP:0007973)1.74546049
123Occipital encephalocele (HP:0002085)1.73100896
124Premature rupture of membranes (HP:0001788)1.72960520
125Abnormal autonomic nervous system physiology (HP:0012332)1.72550152
126Oculomotor apraxia (HP:0000657)1.72331903
127Focal motor seizures (HP:0011153)1.71460005
128Microglossia (HP:0000171)1.71392582
129Hyperventilation (HP:0002883)1.71341720
130Abnormality of the renal cortex (HP:0011035)1.71036591
131Poor coordination (HP:0002370)1.70828959
132Depression (HP:0000716)1.70215919
133Inappropriate behavior (HP:0000719)1.69841452
134Hypokalemia (HP:0002900)1.69539779
135Hyperglycinemia (HP:0002154)1.69146525
136Abnormality of the astrocytes (HP:0100707)1.69076134
137Astrocytoma (HP:0009592)1.69076134
138Abnormality of calcium-phosphate metabolism (HP:0100530)1.68315464
139Visual hallucinations (HP:0002367)1.67321387
140Abnormal auditory evoked potentials (HP:0006958)1.66844847
141Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.66759409
142Specific learning disability (HP:0001328)1.66705254
143Increased circulating renin level (HP:0000848)1.66399438
144Focal seizures (HP:0007359)1.65359558
145Astigmatism (HP:0000483)1.65358834
146Abnormality of macular pigmentation (HP:0008002)1.65172503
147Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.64230989
148Fair hair (HP:0002286)1.63780715
149Decreased testicular size (HP:0008734)1.63351841
150Oligomenorrhea (HP:0000876)1.63157313
151Excessive salivation (HP:0003781)1.63150841
152Cervical subluxation (HP:0003308)1.62781875
153Ankle clonus (HP:0011448)1.62530998
154Methylmalonic acidemia (HP:0002912)1.62095368
155Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.61242505
156Abnormal protein N-linked glycosylation (HP:0012347)1.61242505
157Abnormal protein glycosylation (HP:0012346)1.61242505
158Abnormal glycosylation (HP:0012345)1.61242505
159Adrenal hypoplasia (HP:0000835)1.60936760
160Hypoplasia of the odontoid process (HP:0003311)1.60921956
161Abnormality of the preputium (HP:0100587)1.60607500
162Small hand (HP:0200055)1.60468263
163* Resting tremor (HP:0002322)1.60386743
164Preaxial hand polydactyly (HP:0001177)1.59576450
165Decreased motor nerve conduction velocity (HP:0003431)1.59557216
166Type I transferrin isoform profile (HP:0003642)1.58963985
167Medial flaring of the eyebrow (HP:0010747)1.58276375
168Neoplasm of the adrenal gland (HP:0100631)1.57245449
169Clonus (HP:0002169)1.54730109
170Nephrogenic diabetes insipidus (HP:0009806)1.53701687
171Prostate neoplasm (HP:0100787)1.52425142
172Blue irides (HP:0000635)1.52385679
173Urinary bladder sphincter dysfunction (HP:0002839)1.52224499
174Urinary urgency (HP:0000012)1.51794714
175Drooling (HP:0002307)1.51480675

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.35144191
2SCYL23.31781539
3TRIM283.16339037
4FRK2.92508656
5PASK2.92203215
6AKT32.91169463
7INSRR2.65072385
8WEE12.58169816
9BCR2.54725393
10PLK22.33358163
11PRPF4B2.29167653
12ERBB32.25868682
13NTRK32.24549639
14TSSK62.16130288
15LIMK12.11206423
16SRPK12.08328688
17OXSR12.01242885
18CAMKK21.88852031
19MARK11.83936025
20MET1.83888792
21NEK11.82330968
22BUB11.73036707
23WNK31.72973394
24PDK21.63184936
25MAP3K21.62416850
26PDK41.60520240
27PDK31.60520240
28MAP4K21.54335258
29NTRK11.52726166
30PLK41.48591474
31CCNB11.46218386
32BRSK21.43805149
33ACVR1B1.42877690
34PLK31.41973951
35MINK11.41162375
36TTK1.39970765
37EPHA41.37859031
38MAP3K41.35188901
39PBK1.34844459
40EIF2AK31.29462444
41TESK11.28936356
42CSNK1G11.27279290
43PLK11.17199181
44PNCK1.16004017
45MAP2K71.15912133
46MAP3K121.10903579
47SGK2231.09894955
48SGK4941.09894955
49MST41.08947136
50MST1R1.08481025
51BRAF1.06161926
52PAK61.03982668
53PAK31.02844710
54TNIK1.01679666
55STK38L1.00570347
56STK391.00539009
57CDC70.96913527
58PRKCE0.96404829
59EPHA20.93884221
60MKNK10.92393295
61FER0.91829192
62ERBB40.91413758
63WNK40.91343868
64LATS10.90077848
65SIK30.89211789
66EIF2AK20.87510106
67CDK140.87317586
68KSR10.86823847
69NEK60.86597501
70PRKCG0.84418088
71PINK10.83895788
72MAP3K140.83736638
73BCKDK0.82743234
74STK30.81121574
75DAPK20.79938516
76TAF10.79825817
77CAMKK10.78708347
78CDK50.77647386
79SGK20.76891329
80CDK180.76328343
81PRKD30.73509097
82MYLK0.72656365
83PRKCH0.72307060
84CDK150.69249616
85ATM0.68580399
86FLT30.67348478
87MKNK20.66420004
88MAP2K10.66188251
89CSNK1A1L0.65640352
90CSNK1G20.65563271
91UHMK10.64639450
92CSNK1G30.64539272
93RPS6KA40.63041237
94ATR0.62731021
95BMPR1B0.61701878
96ZAK0.61630841
97DYRK20.60405567
98PDGFRA0.59872020
99YES10.58408050
100EPHA30.57591045
101STK160.56528366
102KSR20.56485678
103AURKB0.56226375
104FGFR10.55626250
105DAPK10.55173969
106BRSK10.55129924
107TRPM70.53701416
108DDR20.53558297
109RET0.53495531
110EIF2AK10.51860723
111VRK10.51264117
112FGR0.50120286
113CAMK2B0.48564472
114TGFBR10.47564190
115NEK90.47260766
116ARAF0.47104647
117SGK30.47057025
118PTK20.46863550
119RPS6KB10.45775248
120BRD40.45509990
121CDK11A0.44115982
122SGK10.43969428
123GRK10.43660295
124MAPK130.41730642
125CDK190.41333830
126EPHB20.40322706
127WNK10.39813898
128CAMK2A0.39717871
129PAK40.38701317
130NEK20.38488245
131NTRK20.38243484
132BMPR20.37713422
133STK240.36650142
134MAPKAPK50.35468218
135ALK0.35173858
136CSNK1E0.33945142
137IGF1R0.33600251
138EGFR0.33590972
139INSR0.32265144
140NUAK10.30805679
141PRKACB0.30636144
142PDPK10.30503927
143ADRBK10.30260573

Predicted pathways (KEGG)

RankGene SetZ-score
1Collecting duct acid secretion_Homo sapiens_hsa049663.61200064
2Vibrio cholerae infection_Homo sapiens_hsa051103.60808605
3Synaptic vesicle cycle_Homo sapiens_hsa047213.28563211
4Protein export_Homo sapiens_hsa030603.04067979
5Propanoate metabolism_Homo sapiens_hsa006402.81899064
6Maturity onset diabetes of the young_Homo sapiens_hsa049502.76262145
7Mismatch repair_Homo sapiens_hsa034302.54265694
8Phagosome_Homo sapiens_hsa041452.51473067
9Lysosome_Homo sapiens_hsa041422.38861758
10Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.36888718
11Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.26006022
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.03417484
13Fanconi anemia pathway_Homo sapiens_hsa034602.00747613
14Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.97807828
15Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.92150901
16Steroid biosynthesis_Homo sapiens_hsa001001.89930025
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.86480255
18Homologous recombination_Homo sapiens_hsa034401.75550063
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.74057027
20Pyruvate metabolism_Homo sapiens_hsa006201.70596914
21DNA replication_Homo sapiens_hsa030301.68972936
22SNARE interactions in vesicular transport_Homo sapiens_hsa041301.65427139
23Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.64912809
24Insulin secretion_Homo sapiens_hsa049111.64565863
25Rheumatoid arthritis_Homo sapiens_hsa053231.63493333
26Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.63159462
27Sulfur metabolism_Homo sapiens_hsa009201.63056516
28Type I diabetes mellitus_Homo sapiens_hsa049401.61788740
29Nucleotide excision repair_Homo sapiens_hsa034201.55406739
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.50648398
31Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.48838092
32Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.44915419
33Basal transcription factors_Homo sapiens_hsa030221.42318372
34RNA transport_Homo sapiens_hsa030131.42063297
35Oxidative phosphorylation_Homo sapiens_hsa001901.41458749
36Type II diabetes mellitus_Homo sapiens_hsa049301.38933698
37Cell cycle_Homo sapiens_hsa041101.37840579
38N-Glycan biosynthesis_Homo sapiens_hsa005101.32012827
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.29809755
40RNA degradation_Homo sapiens_hsa030181.29472882
41Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.27387835
42Fatty acid metabolism_Homo sapiens_hsa012121.26521702
43Sphingolipid metabolism_Homo sapiens_hsa006001.22792901
44Dopaminergic synapse_Homo sapiens_hsa047281.19886773
45Base excision repair_Homo sapiens_hsa034101.19750574
46Morphine addiction_Homo sapiens_hsa050321.18401651
47Serotonergic synapse_Homo sapiens_hsa047261.15671136
48GABAergic synapse_Homo sapiens_hsa047271.14940659
49Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.13835552
50Parkinsons disease_Homo sapiens_hsa050121.09759190
512-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.08725070
52Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.08522720
53Glutathione metabolism_Homo sapiens_hsa004801.07938280
54Nicotine addiction_Homo sapiens_hsa050331.06485769
55Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.06204028
56beta-Alanine metabolism_Homo sapiens_hsa004101.04436864
57Regulation of autophagy_Homo sapiens_hsa041401.04228907
58Long-term potentiation_Homo sapiens_hsa047201.02620324
59Huntingtons disease_Homo sapiens_hsa050161.01397666
60Amphetamine addiction_Homo sapiens_hsa050311.00636671
61Carbon metabolism_Homo sapiens_hsa012000.98831331
62Peroxisome_Homo sapiens_hsa041460.98623093
63Glycosaminoglycan degradation_Homo sapiens_hsa005310.98269664
64Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.97404021
65Fatty acid degradation_Homo sapiens_hsa000710.95270229
66Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.94901522
67Legionellosis_Homo sapiens_hsa051340.92667461
68Alcoholism_Homo sapiens_hsa050340.92634586
69Cocaine addiction_Homo sapiens_hsa050300.91523684
70Circadian entrainment_Homo sapiens_hsa047130.88816836
71Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.87038950
72Phototransduction_Homo sapiens_hsa047440.86568649
73Cholinergic synapse_Homo sapiens_hsa047250.85210147
74Taste transduction_Homo sapiens_hsa047420.84708164
75Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.84551274
76Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.83638474
77TGF-beta signaling pathway_Homo sapiens_hsa043500.83315945
78Pentose and glucuronate interconversions_Homo sapiens_hsa000400.83147916
79Cysteine and methionine metabolism_Homo sapiens_hsa002700.82941085
80Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.81309301
81Oocyte meiosis_Homo sapiens_hsa041140.80530798
82* Endocytosis_Homo sapiens_hsa041440.78383508
83Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.75942771
84Olfactory transduction_Homo sapiens_hsa047400.75365186
85One carbon pool by folate_Homo sapiens_hsa006700.74659366
86Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.72258302
87Renin-angiotensin system_Homo sapiens_hsa046140.72122961
88Fatty acid elongation_Homo sapiens_hsa000620.71651021
89Purine metabolism_Homo sapiens_hsa002300.71585023
90Long-term depression_Homo sapiens_hsa047300.71160184
91Melanoma_Homo sapiens_hsa052180.71042781
92Alzheimers disease_Homo sapiens_hsa050100.70914678
93Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.70245333
94Phosphatidylinositol signaling system_Homo sapiens_hsa040700.70073975
95Spliceosome_Homo sapiens_hsa030400.69826278
96Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.68652128
97Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.67799554
98Axon guidance_Homo sapiens_hsa043600.67383503
99mTOR signaling pathway_Homo sapiens_hsa041500.66795301
100Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.66707708
101Inositol phosphate metabolism_Homo sapiens_hsa005620.66516405
102Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.65696643
103Tryptophan metabolism_Homo sapiens_hsa003800.65462285
104Metabolic pathways_Homo sapiens_hsa011000.64645147
105Pyrimidine metabolism_Homo sapiens_hsa002400.64505352
106Gap junction_Homo sapiens_hsa045400.63959820
107ErbB signaling pathway_Homo sapiens_hsa040120.63402283
108Ether lipid metabolism_Homo sapiens_hsa005650.62750890
109RNA polymerase_Homo sapiens_hsa030200.60424693
110Glioma_Homo sapiens_hsa052140.59991300
111Butanoate metabolism_Homo sapiens_hsa006500.59663570
112Carbohydrate digestion and absorption_Homo sapiens_hsa049730.59456826
113Folate biosynthesis_Homo sapiens_hsa007900.59096139
114Chemical carcinogenesis_Homo sapiens_hsa052040.59020890
115Tight junction_Homo sapiens_hsa045300.58889678
116Thyroid hormone synthesis_Homo sapiens_hsa049180.58865719
117Non-homologous end-joining_Homo sapiens_hsa034500.58647172
118Vitamin B6 metabolism_Homo sapiens_hsa007500.58352277
119Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.57943359
120Vitamin digestion and absorption_Homo sapiens_hsa049770.57631534
121Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.57361912
122Sphingolipid signaling pathway_Homo sapiens_hsa040710.57335620
123Circadian rhythm_Homo sapiens_hsa047100.57153450
124Renin secretion_Homo sapiens_hsa049240.56364967
125Hippo signaling pathway_Homo sapiens_hsa043900.54769990
126Steroid hormone biosynthesis_Homo sapiens_hsa001400.53932484
127Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.52849763
128Glutamatergic synapse_Homo sapiens_hsa047240.52791930
129Other glycan degradation_Homo sapiens_hsa005110.51925873
130Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.51725975
131Estrogen signaling pathway_Homo sapiens_hsa049150.50782194
132p53 signaling pathway_Homo sapiens_hsa041150.50738290
133Endometrial cancer_Homo sapiens_hsa052130.50156247
134Renal cell carcinoma_Homo sapiens_hsa052110.49767488
135Drug metabolism - other enzymes_Homo sapiens_hsa009830.49276191
136Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49199921
137Viral carcinogenesis_Homo sapiens_hsa052030.47549251
138Arginine and proline metabolism_Homo sapiens_hsa003300.46881552
139Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.46695521
140Primary bile acid biosynthesis_Homo sapiens_hsa001200.45327978
141Histidine metabolism_Homo sapiens_hsa003400.44587044
142Focal adhesion_Homo sapiens_hsa045100.44290746
143mRNA surveillance pathway_Homo sapiens_hsa030150.43831989
144Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.43672970
145Proteasome_Homo sapiens_hsa030500.42597221
146Regulation of actin cytoskeleton_Homo sapiens_hsa048100.40974311
147Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.40175065
148Ras signaling pathway_Homo sapiens_hsa040140.40063781
149Starch and sucrose metabolism_Homo sapiens_hsa005000.39136761
150Tuberculosis_Homo sapiens_hsa051520.38641095
151Prion diseases_Homo sapiens_hsa050200.37341787
152Fatty acid biosynthesis_Homo sapiens_hsa000610.36466511
153Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.35978759
154Colorectal cancer_Homo sapiens_hsa052100.35561883
155Selenocompound metabolism_Homo sapiens_hsa004500.34584704
156Prostate cancer_Homo sapiens_hsa052150.34418917
157PI3K-Akt signaling pathway_Homo sapiens_hsa041510.32162267
158Shigellosis_Homo sapiens_hsa051310.31777666
159Salmonella infection_Homo sapiens_hsa051320.31425555
160Neurotrophin signaling pathway_Homo sapiens_hsa047220.30504400
161Vascular smooth muscle contraction_Homo sapiens_hsa042700.30388002
162Oxytocin signaling pathway_Homo sapiens_hsa049210.29836565
163Pancreatic cancer_Homo sapiens_hsa052120.29637800
164Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.29141588
165Antigen processing and presentation_Homo sapiens_hsa046120.28443791

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