VPS36

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is a subunit of the endosomal sorting complex required for transport II (ESCRT-II). This protein complex functions in sorting of ubiquitinated membrane proteins during endocytosis. A similar protein complex in rat is associated with RNA polymerase elongation factor II. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)7.73070152
2viral transcription (GO:0019083)6.49726309
3translational termination (GO:0006415)6.37899775
4ribosomal small subunit biogenesis (GO:0042274)6.05869732
5SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.68961794
6cotranslational protein targeting to membrane (GO:0006613)5.59126735
7protein targeting to ER (GO:0045047)5.54791915
8translational elongation (GO:0006414)5.49972300
9maturation of SSU-rRNA (GO:0030490)5.29563081
10establishment of protein localization to endoplasmic reticulum (GO:0072599)5.26994836
11protein localization to endoplasmic reticulum (GO:0070972)5.21262070
12viral life cycle (GO:0019058)5.03051713
13cellular protein complex disassembly (GO:0043624)4.95872150
14nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.91741887
15translational initiation (GO:0006413)4.87778567
16ribosomal large subunit biogenesis (GO:0042273)4.36557690
17protein complex disassembly (GO:0043241)4.34675989
18protein targeting to Golgi (GO:0000042)4.17050268
19formation of translation preinitiation complex (GO:0001731)4.13029737
20macromolecular complex disassembly (GO:0032984)4.10705117
21establishment of protein localization to Golgi (GO:0072600)4.07715575
22DNA unwinding involved in DNA replication (GO:0006268)4.01123194
23telomere maintenance via semi-conservative replication (GO:0032201)4.00752231
24DNA strand elongation involved in DNA replication (GO:0006271)3.96462215
25translation (GO:0006412)3.95317663
26retrograde transport, vesicle recycling within Golgi (GO:0000301)3.85731854
27phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.82656258
28positive regulation of gamma-delta T cell activation (GO:0046645)3.81053469
29DNA strand elongation (GO:0022616)3.80282904
30ether lipid metabolic process (GO:0046485)3.78777153
31cellular response to ethanol (GO:0071361)3.76246813
32definitive hemopoiesis (GO:0060216)3.71351112
33nuclear-transcribed mRNA catabolic process (GO:0000956)3.71148949
34ribonucleoprotein complex biogenesis (GO:0022613)3.71063990
35protein targeting to membrane (GO:0006612)3.67096480
36DNA deamination (GO:0045006)3.59295076
37regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.55624244
38regulation of germinal center formation (GO:0002634)3.54637010
39telomere maintenance via recombination (GO:0000722)3.53599016
40mRNA catabolic process (GO:0006402)3.50242080
41establishment of integrated proviral latency (GO:0075713)3.44598052
42regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.43669679
43DNA replication initiation (GO:0006270)3.42455999
44regulation of hypersensitivity (GO:0002883)3.41333124
45mitotic recombination (GO:0006312)3.41295196
46neutrophil activation involved in immune response (GO:0002283)3.34721613
47regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.32156245
48RNA catabolic process (GO:0006401)3.31284270
49early endosome to late endosome transport (GO:0045022)3.29505489
50carnitine transport (GO:0015879)3.21386716
51amino-acid betaine transport (GO:0015838)3.21386716
52CENP-A containing nucleosome assembly (GO:0034080)3.19501597
53protein prenylation (GO:0018342)3.19220565
54prenylation (GO:0097354)3.19220565
55carnitine transmembrane transport (GO:1902603)3.17857418
56activated T cell proliferation (GO:0050798)3.17136560
57regulation of skeletal muscle cell differentiation (GO:2001014)3.16275454
58positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.14817106
59deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.13132901
60regulation of pigment cell differentiation (GO:0050932)3.10481983
61positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.09421524
62intracellular lipid transport (GO:0032365)3.08817187
63chromatin remodeling at centromere (GO:0031055)3.08114297
64rRNA processing (GO:0006364)3.07676755
65negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.05999895
66telomere maintenance via telomere lengthening (GO:0010833)3.05407959
67regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.04430032
68regulation of B cell receptor signaling pathway (GO:0050855)3.03441187
69DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.02473693
70nucleotide-excision repair, DNA gap filling (GO:0006297)3.02436588
71antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.01110925
72positive regulation of cardiac muscle hypertrophy (GO:0010613)3.01031041
73positive regulation of muscle hypertrophy (GO:0014742)3.01031041
74positive regulation of mast cell degranulation (GO:0043306)2.99430502
75positive regulation of mast cell activation involved in immune response (GO:0033008)2.99430502
76cellular component biogenesis (GO:0044085)2.98232243
77intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.97534829
78signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.97534829
79positive regulation of granulocyte differentiation (GO:0030854)2.95983909
80cell differentiation involved in metanephros development (GO:0072202)2.95632270
81kinetochore organization (GO:0051383)2.94652605
82positive regulation of digestive system process (GO:0060456)2.92913711
83signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.92585476
84signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.92585476
85signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.92585476
86rRNA metabolic process (GO:0016072)2.90364599
87tachykinin receptor signaling pathway (GO:0007217)2.89726317
88antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.89643055
89relaxation of cardiac muscle (GO:0055119)2.89361173
90regulation of clathrin-mediated endocytosis (GO:2000369)2.89270261
91regulation of relaxation of muscle (GO:1901077)2.88235019
92establishment of viral latency (GO:0019043)2.85278334
93spliceosomal snRNP assembly (GO:0000387)2.84909699
94DNA damage response, detection of DNA damage (GO:0042769)2.84590509
95signal transduction involved in DNA damage checkpoint (GO:0072422)2.84396183
96signal transduction involved in DNA integrity checkpoint (GO:0072401)2.84396183
97regulation of gamma-delta T cell differentiation (GO:0045586)2.83802564
98flavonoid metabolic process (GO:0009812)2.83673704
99mRNA modification (GO:0016556)2.83220207
100regulation of protein glycosylation (GO:0060049)2.81955515
101relaxation of smooth muscle (GO:0044557)2.81627771
102nerve growth factor signaling pathway (GO:0038180)2.80524701
103positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.79999611
104protein targeting to vacuole (GO:0006623)2.79877147
105protein targeting to lysosome (GO:0006622)2.79877147
106establishment of protein localization to vacuole (GO:0072666)2.79877147
107mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.79191335
108nucleobase biosynthetic process (GO:0046112)2.78738589
109negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.78667260
110negative regulation of ligase activity (GO:0051352)2.78667260
111negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.78663141
112signal transduction involved in cell cycle checkpoint (GO:0072395)2.78187673
113thrombin receptor signaling pathway (GO:0070493)2.78164364
114regulation of acute inflammatory response to antigenic stimulus (GO:0002864)2.78117806
115nucleobase-containing small molecule interconversion (GO:0015949)2.77714352
116antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.77090277
117cellular glucuronidation (GO:0052695)2.76440388
118regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.76248142
119relaxation of muscle (GO:0090075)2.75211694
120exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.75087577
121regulation of platelet aggregation (GO:0090330)2.74614359
122inositol phosphate catabolic process (GO:0071545)2.73485366
123regulation of sarcomere organization (GO:0060297)2.73129501
124protein localization to Golgi apparatus (GO:0034067)2.71697976
125pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.71451969
126DNA replication checkpoint (GO:0000076)2.70583135
127pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.70076142
128viral mRNA export from host cell nucleus (GO:0046784)2.68721320
129Arp2/3 complex-mediated actin nucleation (GO:0034314)2.67772183
130nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.66144961
131transcription-coupled nucleotide-excision repair (GO:0006283)2.65568343
132anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.64987786
133ATP synthesis coupled proton transport (GO:0015986)2.64763431
134energy coupled proton transport, down electrochemical gradient (GO:0015985)2.64763431
135Golgi to endosome transport (GO:0006895)2.64546142
136folic acid-containing compound biosynthetic process (GO:0009396)2.64244542
137purine nucleobase biosynthetic process (GO:0009113)2.64020307
138regulation of cellular amino acid metabolic process (GO:0006521)2.63936508
139glucuronate metabolic process (GO:0019585)2.62601658
140uronic acid metabolic process (GO:0006063)2.62601658
141lipid translocation (GO:0034204)2.62510019
142phospholipid translocation (GO:0045332)2.62510019
143negative T cell selection (GO:0043383)2.62470280
144IMP biosynthetic process (GO:0006188)2.62283777
145negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.61150231
146spliceosomal complex assembly (GO:0000245)2.60913872
147cell cycle G1/S phase transition (GO:0044843)2.60230674
148G1/S transition of mitotic cell cycle (GO:0000082)2.60230674
149DNA replication-independent nucleosome assembly (GO:0006336)2.60172744
150DNA replication-independent nucleosome organization (GO:0034724)2.60172744
151polyol catabolic process (GO:0046174)2.60118038
152pseudouridine synthesis (GO:0001522)2.59917198
153endothelium development (GO:0003158)2.59632582
154IMP metabolic process (GO:0046040)2.59517363
155megakaryocyte development (GO:0035855)2.58887735
156positive regulation of mast cell activation (GO:0033005)2.58842055
157adenosine metabolic process (GO:0046085)2.57325100
158negative regulation of T cell mediated immunity (GO:0002710)2.57215886
159secondary heart field specification (GO:0003139)2.55671649
160heart field specification (GO:0003128)2.55671649
161ribosome biogenesis (GO:0042254)2.54972496
162regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.54695733
163positive regulation of vasculogenesis (GO:2001214)2.54644900
164GTP biosynthetic process (GO:0006183)2.54095503
165protein localization to kinetochore (GO:0034501)2.53874442
166proteasome assembly (GO:0043248)2.53160239
167histone mRNA metabolic process (GO:0008334)2.53101683
168regulation of gamma-delta T cell activation (GO:0046643)2.52944976
169platelet dense granule organization (GO:0060155)2.52536508
170UTP biosynthetic process (GO:0006228)2.52445824
171negative regulation of cell killing (GO:0031342)2.51782772
172negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.51782772
173positive regulation of glycolytic process (GO:0045821)2.51754023
174membrane budding (GO:0006900)2.50878040
175positive regulation of cell cycle arrest (GO:0071158)2.49942918
176negative regulation of adaptive immune response (GO:0002820)2.48777622
177DNA ligation (GO:0006266)2.46862463
178DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.46613073
179regulation of B cell differentiation (GO:0045577)2.46529042
180positive regulation of B cell differentiation (GO:0045579)2.45916036
181telomere organization (GO:0032200)2.45332316
182B cell receptor signaling pathway (GO:0050853)2.44968026
183succinate metabolic process (GO:0006105)2.44960598
184inositol phosphate dephosphorylation (GO:0046855)2.44398315
185phosphorylated carbohydrate dephosphorylation (GO:0046838)2.44398315
186angiotensin maturation (GO:0002003)2.43918322
187ncRNA 3-end processing (GO:0043628)2.43809888
188peroxisome fission (GO:0016559)2.42766258
189nucleoside diphosphate catabolic process (GO:0009134)2.41963875
190interferon-gamma-mediated signaling pathway (GO:0060333)2.40012795
191dendritic cell migration (GO:0036336)2.39400107
192regulation of vasculogenesis (GO:2001212)2.38923457
193carnitine shuttle (GO:0006853)2.37966735
194dentate gyrus development (GO:0021542)2.37086354
195antigen processing and presentation of endogenous antigen (GO:0019883)2.35031773
196detection of other organism (GO:0098543)2.34355802
197regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.34244103
198cellular extravasation (GO:0045123)2.33472721
199negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.33444771
200production of molecular mediator of immune response (GO:0002440)2.32887991

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.84656931
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.39394964
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.82734933
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.65979999
5POU3F2_20337985_ChIP-ChIP_501MEL_Human3.24068278
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.18218632
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.13500007
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.07436067
9E2F4_17652178_ChIP-ChIP_JURKAT_Human3.03928436
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.91730969
11FOXM1_23109430_ChIP-Seq_U2OS_Human2.78669584
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.77848738
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.77198232
14* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.73818128
15VDR_22108803_ChIP-Seq_LS180_Human2.71122496
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.63111151
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.59203918
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.57258638
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.55801031
20ETS1_20019798_ChIP-Seq_JURKAT_Human2.55612182
21FUS_26573619_Chip-Seq_HEK293_Human2.52601190
22SALL1_21062744_ChIP-ChIP_HESCs_Human2.49466662
23CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.40777509
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.40057460
25XRN2_22483619_ChIP-Seq_HELA_Human2.39649062
26NELFA_20434984_ChIP-Seq_ESCs_Mouse2.34720357
27GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.34600306
28GATA1_22025678_ChIP-Seq_K562_Human2.33575634
29VDR_23849224_ChIP-Seq_CD4+_Human2.30973772
30TAF15_26573619_Chip-Seq_HEK293_Human2.29224272
31ELK1_19687146_ChIP-ChIP_HELA_Human2.28050110
32ZFP57_27257070_Chip-Seq_ESCs_Mouse2.24070923
33NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.17613189
34IGF1R_20145208_ChIP-Seq_DFB_Human2.17177468
35* DCP1A_22483619_ChIP-Seq_HELA_Human2.15595717
36RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.15319941
37SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.14264316
38TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.11297813
39E2F1_18555785_ChIP-Seq_MESCs_Mouse2.09705737
40FLI1_27457419_Chip-Seq_LIVER_Mouse2.08626824
41PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.07481654
42FOXP3_21729870_ChIP-Seq_TREG_Human2.04281774
43HOXB4_20404135_ChIP-ChIP_EML_Mouse1.95994838
44CDX2_19796622_ChIP-Seq_MESCs_Mouse1.93724483
45EGR1_19374776_ChIP-ChIP_THP-1_Human1.92508080
46HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.91810926
47TTF2_22483619_ChIP-Seq_HELA_Human1.89907520
48EZH2_27294783_Chip-Seq_NPCs_Mouse1.86050179
49EWS_26573619_Chip-Seq_HEK293_Human1.85985488
50FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.84485267
51AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.82779405
52RBPJ_22232070_ChIP-Seq_NCS_Mouse1.82004668
53HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.80009539
54P300_19829295_ChIP-Seq_ESCs_Human1.79550300
55GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.76749363
56IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.76644386
57PCGF2_27294783_Chip-Seq_ESCs_Mouse1.75043515
58E2F1_21310950_ChIP-Seq_MCF-7_Human1.72272364
59SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.70212682
60CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.69012778
61FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.68990350
62* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.68255667
63PIAS1_25552417_ChIP-Seq_VCAP_Human1.67454510
64PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.66070429
65TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.63669564
66* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.63402833
67SUZ12_27294783_Chip-Seq_NPCs_Mouse1.62381224
68NANOG_18555785_Chip-Seq_ESCs_Mouse1.62207477
69SRF_21415370_ChIP-Seq_HL-1_Mouse1.60997325
70GABP_19822575_ChIP-Seq_HepG2_Human1.60904468
71SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.60678770
72IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.60625268
73* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.58512878
74TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.57526911
75* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.57154942
76AR_21909140_ChIP-Seq_LNCAP_Human1.56904277
77OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.56481003
78EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.55586044
79GBX2_23144817_ChIP-Seq_PC3_Human1.53906520
80ER_23166858_ChIP-Seq_MCF-7_Human1.52157229
81MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.51705265
82SMAD4_21799915_ChIP-Seq_A2780_Human1.50770460
83STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.48287980
84CDX2_22108803_ChIP-Seq_LS180_Human1.46474334
85NFE2_27457419_Chip-Seq_LIVER_Mouse1.46382990
86E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.46268144
87CRX_20693478_ChIP-Seq_RETINA_Mouse1.45420925
88ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.44951192
89OCT4_21477851_ChIP-Seq_ESCs_Mouse1.44635793
90E2F1_18555785_Chip-Seq_ESCs_Mouse1.44306097
91SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.43823263
92P53_22387025_ChIP-Seq_ESCs_Mouse1.43589391
93* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.43356830
94FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.42835343
95PCGF2_27294783_Chip-Seq_NPCs_Mouse1.39589024
96THAP11_20581084_ChIP-Seq_MESCs_Mouse1.39527239
97TP63_17297297_ChIP-ChIP_HaCaT_Human1.39410032
98BCAT_22108803_ChIP-Seq_LS180_Human1.38942712
99* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.38867140
100CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.38568965
101ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.38174099
102FOXM1_26456572_ChIP-Seq_MCF-7_Human1.38134305
103CMYC_18555785_Chip-Seq_ESCs_Mouse1.37717024
104* SPI1_23547873_ChIP-Seq_NB4_Human1.37586946
105TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36603374
106UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.36206966
107FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.34777843
108NOTCH1_21737748_ChIP-Seq_TLL_Human1.34111930
109MYC_22102868_ChIP-Seq_BL_Human1.33474306
110STAT3_23295773_ChIP-Seq_U87_Human1.32172838
111FLI1_21867929_ChIP-Seq_TH2_Mouse1.31235418
112Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.29263831
113CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.28162287
114P300_18555785_Chip-Seq_ESCs_Mouse1.28022487
115SMAD3_21741376_ChIP-Seq_EPCs_Human1.27882294
116RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.27628594
117BP1_19119308_ChIP-ChIP_Hs578T_Human1.27105606
118CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.27022769
119ELK1_22589737_ChIP-Seq_MCF10A_Human1.26935359
120FOXA1_21572438_ChIP-Seq_LNCaP_Human1.25541461
121FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.25246325
122MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.25056210
123STAT4_19710469_ChIP-ChIP_TH1__Mouse1.24893813
124SUZ12_18555785_Chip-Seq_ESCs_Mouse1.24870125
125SMAD_19615063_ChIP-ChIP_OVARY_Human1.24725548
126SALL4_22934838_ChIP-ChIP_CD34+_Human1.24373622
127STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.23891358
128STAT3_18555785_Chip-Seq_ESCs_Mouse1.22971934
129CIITA_25753668_ChIP-Seq_RAJI_Human1.22817597
130RUNX_20019798_ChIP-Seq_JUKART_Human1.22804244
131POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.22311787
132TCF4_23295773_ChIP-Seq_U87_Human1.21968822
133TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21422548
134TCF4_22108803_ChIP-Seq_LS180_Human1.21415170
135OCT4_18555785_Chip-Seq_ESCs_Mouse1.20015949
136PRDM14_20953172_ChIP-Seq_ESCs_Human1.19495592
137YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.19464072
138NANOG_19829295_ChIP-Seq_ESCs_Human1.19360345
139SOX2_19829295_ChIP-Seq_ESCs_Human1.19360345
140TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.19154689
141SOX2_18555785_Chip-Seq_ESCs_Mouse1.18745777
142* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.18650697
143IRF8_22096565_ChIP-ChIP_GC-B_Human1.18633405
144TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.18585101
145EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.16424898
146PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14727356
147* CBP_20019798_ChIP-Seq_JUKART_Human1.14623091
148* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.14623091
149TAL1_26923725_Chip-Seq_HPCs_Mouse1.14006236
150PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.13692735
151CTBP2_25329375_ChIP-Seq_LNCAP_Human1.12773293
152NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.12740231
153NRF2_20460467_ChIP-Seq_MEFs_Mouse1.12740231
154CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.11556328
155IRF8_27001747_Chip-Seq_BMDM_Mouse1.08757403
156MYB_21317192_ChIP-Seq_ERMYB_Mouse1.08003453
157YY1_21170310_ChIP-Seq_MESCs_Mouse1.07846421
158PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.07692612
159EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.07548565
160VDR_24787735_ChIP-Seq_THP-1_Human1.07365518
161STAT3_1855785_ChIP-Seq_MESCs_Mouse1.07357039
162NANOG_18555785_ChIP-Seq_MESCs_Mouse1.07140447
163NMYC_18555785_Chip-Seq_ESCs_Mouse1.06999305
164RUNX1_27457419_Chip-Seq_LIVER_Mouse1.06946968
165PADI4_21655091_ChIP-ChIP_MCF-7_Human1.06895006
166SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.06351038
167IRF8_21731497_ChIP-ChIP_J774_Mouse1.05794728
168CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.05697813
169NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05206735
170CTCF_18555785_Chip-Seq_ESCs_Mouse1.04762826
171RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.03721863
172VDR_21846776_ChIP-Seq_THP-1_Human1.03402926
173MYC_18940864_ChIP-ChIP_HL60_Human1.03129162
174SCL_19346495_ChIP-Seq_HPC-7_Human1.02634888
175POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.01700043
176TFEB_21752829_ChIP-Seq_HELA_Human1.00849230
177ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.99341058
178KDM5A_27292631_Chip-Seq_BREAST_Human0.96850486
179KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.96340326
180CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.96219725
181* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.94431963
182* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.93702132
183SOX2_18555785_ChIP-Seq_MESCs_Mouse0.92637693
184BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.91188528
185HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.90711492
186MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.90504095
187MYB_26560356_Chip-Seq_TH2_Human0.90089511
188CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.89872479
189POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.89700600
190KLF4_18555785_ChIP-Seq_MESCs_Mouse0.89036396

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.80965417
2MP0003693_abnormal_embryo_hatching3.89998483
3MP0009379_abnormal_foot_pigmentation3.85987629
4MP0002009_preneoplasia3.67230848
5MP0004957_abnormal_blastocyst_morpholog3.17343877
6MP0010094_abnormal_chromosome_stability2.75071487
7MP0004147_increased_porphyrin_level2.65647945
8MP0004084_abnormal_cardiac_muscle2.63510363
9MP0002396_abnormal_hematopoietic_system2.57504917
10MP0003077_abnormal_cell_cycle2.55014465
11MP0006054_spinal_hemorrhage2.49926541
12MP0008007_abnormal_cellular_replicative2.46491624
13MP0004215_abnormal_myocardial_fiber2.45808022
14MP0004043_abnormal_pH_regulation2.40452403
15MP0001501_abnormal_sleep_pattern2.31658363
16MP0010352_gastrointestinal_tract_polyps2.22692477
17MP0004484_altered_response_of2.19445440
18MP0001835_abnormal_antigen_presentation2.16848797
19MP0003763_abnormal_thymus_physiology2.15101688
20MP0008057_abnormal_DNA_replication2.14359757
21MP0003880_abnormal_central_pattern2.12652358
22MP0005085_abnormal_gallbladder_physiolo2.11172621
23MP0003111_abnormal_nucleus_morphology2.04324005
24MP0001986_abnormal_taste_sensitivity2.00376217
25MP0008058_abnormal_DNA_repair1.86036815
26MP0000490_abnormal_crypts_of1.85830266
27MP0009785_altered_susceptibility_to1.82866915
28MP0002132_abnormal_respiratory_system1.79694552
29MP0008932_abnormal_embryonic_tissue1.73029496
30MP0004036_abnormal_muscle_relaxation1.69759328
31MP0003186_abnormal_redox_activity1.68586694
32MP0004808_abnormal_hematopoietic_stem1.62056087
33MP0001188_hyperpigmentation1.62048371
34MP0003191_abnormal_cellular_cholesterol1.61682874
35MP0002148_abnormal_hypersensitivity_rea1.56684659
36MP0000015_abnormal_ear_pigmentation1.55299456
37MP0003436_decreased_susceptibility_to1.51921900
38MP0003941_abnormal_skin_development1.49496033
39MP0002166_altered_tumor_susceptibility1.48858756
40MP0009333_abnormal_splenocyte_physiolog1.48636839
41MP0003567_abnormal_fetal_cardiomyocyte1.47617023
42MP0001853_heart_inflammation1.46370534
43MP0003828_pulmonary_edema1.46096443
44MP0002398_abnormal_bone_marrow1.44070078
45MP0002452_abnormal_antigen_presenting1.44002418
46MP0001800_abnormal_humoral_immune1.43722046
47MP0000858_altered_metastatic_potential1.41626061
48MP0005025_abnormal_response_to1.41240457
49MP0002420_abnormal_adaptive_immunity1.41059087
50MP0002277_abnormal_respiratory_mucosa1.41003396
51MP0002837_dystrophic_cardiac_calcinosis1.40611819
52MP0003195_calcinosis1.39574845
53MP0006036_abnormal_mitochondrial_physio1.38092129
54MP0001819_abnormal_immune_cell1.37926917
55MP0008438_abnormal_cutaneous_collagen1.37851707
56MP0002722_abnormal_immune_system1.35947656
57MP0000350_abnormal_cell_proliferation1.34929457
58MP0002405_respiratory_system_inflammati1.34549950
59MP0003806_abnormal_nucleotide_metabolis1.34378873
60MP0001730_embryonic_growth_arrest1.33045300
61MP0001851_eye_inflammation1.32855878
62MP0009697_abnormal_copulation1.32418828
63MP0004885_abnormal_endolymph1.31615944
64MP0000685_abnormal_immune_system1.30920010
65MP0000689_abnormal_spleen_morphology1.29287650
66MP0005671_abnormal_response_to1.29006506
67MP0010386_abnormal_urinary_bladder1.27590432
68MP0002019_abnormal_tumor_incidence1.26896750
69MP0002723_abnormal_immune_serum1.25742500
70MP0000703_abnormal_thymus_morphology1.25462252
71MP0005000_abnormal_immune_tolerance1.24692892
72MP0010030_abnormal_orbit_morphology1.23494096
73MP0003252_abnormal_bile_duct1.22685403
74MP0001664_abnormal_digestion1.22584616
75MP0003866_abnormal_defecation1.22537141
76MP0000716_abnormal_immune_system1.22076988
77MP0002429_abnormal_blood_cell1.20222481
78MP0003786_premature_aging1.18861083
79MP0004264_abnormal_extraembryonic_tissu1.18329901
80MP0002006_tumorigenesis1.17877535
81MP0005174_abnormal_tail_pigmentation1.17224762
82MP0010155_abnormal_intestine_physiology1.17115078
83MP0000465_gastrointestinal_hemorrhage1.15537715
84MP0000427_abnormal_hair_cycle1.15241507
85MP0000313_abnormal_cell_death1.15086784
86MP0010368_abnormal_lymphatic_system1.14591366
87MP0003045_fibrosis1.10926493
88MP0002876_abnormal_thyroid_physiology1.10030574
89MP0001545_abnormal_hematopoietic_system1.09498787
90MP0005397_hematopoietic_system_phenotyp1.09498787
91MP0004130_abnormal_muscle_cell1.07646288
92MP0004782_abnormal_surfactant_physiolog1.07299287
93MP0005360_urolithiasis1.06847533
94MP0005535_abnormal_body_temperature1.06378006
95MP0001879_abnormal_lymphatic_vessel1.06064794
96MP0005023_abnormal_wound_healing1.05029067
97MP0002419_abnormal_innate_immunity1.03222792
98MP0002796_impaired_skin_barrier1.03070927
99MP0002938_white_spotting1.02734951
100MP0008004_abnormal_stomach_pH1.01357009
101MP0005408_hypopigmentation0.99991221
102MP0001697_abnormal_embryo_size0.98538638
103MP0001765_abnormal_ion_homeostasis0.97998894
104MP0009053_abnormal_anal_canal0.97414000
105MP0004883_abnormal_blood_vessel0.96870940
106MP0005501_abnormal_skin_physiology0.96003911
107MP0005385_cardiovascular_system_phenoty0.95865456
108MP0001544_abnormal_cardiovascular_syste0.95865456
109MP0005084_abnormal_gallbladder_morpholo0.93660513
110MP0002095_abnormal_skin_pigmentation0.91521767
111MP0003566_abnormal_cell_adhesion0.91045397
112MP0002080_prenatal_lethality0.91017493
113MP0000537_abnormal_urethra_morphology0.90930514
114MP0008875_abnormal_xenobiotic_pharmacok0.90567415
115MP0003943_abnormal_hepatobiliary_system0.90146579
116MP0005464_abnormal_platelet_physiology0.89467235
117MP0003724_increased_susceptibility_to0.89363472
118MP0001790_abnormal_immune_system0.88942648
119MP0005387_immune_system_phenotype0.88942648
120MP0002060_abnormal_skin_morphology0.88888439
121MP0000372_irregular_coat_pigmentation0.88208352
122MP0001764_abnormal_homeostasis0.86404245
123MP0005365_abnormal_bile_salt0.86389916
124MP0005075_abnormal_melanosome_morpholog0.86079996
125MP0005275_abnormal_skin_tensile0.85820651
126MP0004134_abnormal_chest_morphology0.85355674
127MP0005380_embryogenesis_phenotype0.85264175
128MP0001672_abnormal_embryogenesis/_devel0.85264175
129MP0001873_stomach_inflammation0.85240049
130MP0008775_abnormal_heart_ventricle0.85161799
131MP0003984_embryonic_growth_retardation0.84948511
132MP0002088_abnormal_embryonic_growth/wei0.84523065
133MP0009780_abnormal_chondrocyte_physiolo0.83940240
134MP0001845_abnormal_inflammatory_respons0.82521877
135MP0001915_intracranial_hemorrhage0.81947164
136MP0005166_decreased_susceptibility_to0.81577878
137MP0005332_abnormal_amino_acid0.80850553
138MP0002972_abnormal_cardiac_muscle0.80747634
139MP0010307_abnormal_tumor_latency0.80449754
140MP0008995_early_reproductive_senescence0.80200762
141MP0001216_abnormal_epidermal_layer0.79509261
142MP0002098_abnormal_vibrissa_morphology0.79223991
143MP0003448_altered_tumor_morphology0.78918297
144MP0000343_altered_response_to0.77755968
145MP0003183_abnormal_peptide_metabolism0.77599960
146MP0005388_respiratory_system_phenotype0.77538267
147MP0002133_abnormal_respiratory_system0.77538267
148MP0001666_abnormal_nutrient_absorption0.77494065
149MP0001486_abnormal_startle_reflex0.75882562
150MP0001191_abnormal_skin_condition0.74911061
151MP0001243_abnormal_dermal_layer0.73388516
152MP0002127_abnormal_cardiovascular_syste0.73193922
153MP0001293_anophthalmia0.72755794
154MP0004947_skin_inflammation0.72204800
155MP0002086_abnormal_extraembryonic_tissu0.71172788
156MP0000377_abnormal_hair_follicle0.71040549
157MP0005266_abnormal_metabolism0.70249048
158MP0005551_abnormal_eye_electrophysiolog0.69972460
159MP0004197_abnormal_fetal_growth/weight/0.69037557
160MP0000383_abnormal_hair_follicle0.68042637
161MP0010329_abnormal_lipoprotein_level0.65207566
162MP0005620_abnormal_muscle_contractility0.64381531

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)5.71417685
2Abnormality of cells of the erythroid lineage (HP:0012130)5.30038870
3Abnormal number of erythroid precursors (HP:0012131)4.82480446
4Thrombocytosis (HP:0001894)3.87312029
5Central scotoma (HP:0000603)3.76008828
6Macrocytic anemia (HP:0001972)3.73516244
7Papilledema (HP:0001085)3.67303601
8Pallor (HP:0000980)3.63368251
9Aplasia/Hypoplasia of the sacrum (HP:0008517)3.38683385
10Aplastic anemia (HP:0001915)3.19584223
11Colon cancer (HP:0003003)3.17486375
12Elevated erythrocyte sedimentation rate (HP:0003565)3.15402269
13Increased hepatocellular lipid droplets (HP:0006565)3.14274556
14IgM deficiency (HP:0002850)3.14123919
15Renal cortical cysts (HP:0000803)3.07857193
16Abnormality of macular pigmentation (HP:0008002)3.07327861
17Papillary thyroid carcinoma (HP:0002895)3.03969292
1811 pairs of ribs (HP:0000878)3.02965968
19Exertional dyspnea (HP:0002875)2.93334255
20Stomach cancer (HP:0012126)2.91684790
21Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.87259774
22Lipid accumulation in hepatocytes (HP:0006561)2.86338959
23Abnormality of glycolysis (HP:0004366)2.75627765
24Increased serum pyruvate (HP:0003542)2.75627765
25Mitochondrial inheritance (HP:0001427)2.74125146
26Abnormal hemoglobin (HP:0011902)2.70336629
27Decreased activity of mitochondrial respiratory chain (HP:0008972)2.67126443
28Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.67126443
29Acute myeloid leukemia (HP:0004808)2.66056957
30Recurrent cutaneous fungal infections (HP:0011370)2.65377326
31Chronic mucocutaneous candidiasis (HP:0002728)2.65377326
32Albinism (HP:0001022)2.63296895
33Metabolic alkalosis (HP:0200114)2.62811065
34Abnormality of the vitamin B12 metabolism (HP:0004341)2.61472237
35Myositis (HP:0100614)2.59692317
36Abnormality of vitamin B metabolism (HP:0004340)2.54173449
37Abnormality of cochlea (HP:0000375)2.52650253
38Volvulus (HP:0002580)2.49707576
39Type I transferrin isoform profile (HP:0003642)2.49049972
40Rough bone trabeculation (HP:0100670)2.48431900
41Increased CSF lactate (HP:0002490)2.47857995
42Abnormality of T cell number (HP:0011839)2.46826984
43Pheochromocytoma (HP:0002666)2.46245049
44Right ventricular cardiomyopathy (HP:0011663)2.46141058
45Thyroiditis (HP:0100646)2.45876931
46Respiratory difficulties (HP:0002880)2.44284979
47T lymphocytopenia (HP:0005403)2.44205754
48Sudden death (HP:0001699)2.43967900
49Acute necrotizing encephalopathy (HP:0006965)2.42760452
50Hypothermia (HP:0002045)2.41969898
51Conjunctival hamartoma (HP:0100780)2.41593750
52Facial diplegia (HP:0001349)2.40268256
53Thyroid carcinoma (HP:0002890)2.39975920
54Calf muscle hypertrophy (HP:0008981)2.39715413
55Abnormality of aspartate family amino acid metabolism (HP:0010899)2.38965772
56Scotoma (HP:0000575)2.38912695
57Febrile seizures (HP:0002373)2.38204237
58Oral leukoplakia (HP:0002745)2.37850062
59Hepatocellular necrosis (HP:0001404)2.34649718
60Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.34160833
61Xerostomia (HP:0000217)2.33869096
62Microretrognathia (HP:0000308)2.33421795
63Premature graying of hair (HP:0002216)2.32626648
64Birth length less than 3rd percentile (HP:0003561)2.32134933
65Recurrent skin infections (HP:0001581)2.31654916
66Increased serum lactate (HP:0002151)2.30970174
67Abnormality of the renal cortex (HP:0011035)2.30637817
68Abnormality of B cell number (HP:0010975)2.29235832
69B lymphocytopenia (HP:0010976)2.29235832
70Neuroendocrine neoplasm (HP:0100634)2.27095348
71Atonic seizures (HP:0010819)2.26363139
72Hepatic necrosis (HP:0002605)2.25847033
73Neoplasm of the small intestine (HP:0100833)2.24274516
74Abnormality of methionine metabolism (HP:0010901)2.24062345
75Subaortic stenosis (HP:0001682)2.23090354
76Abnormality of the left ventricular outflow tract (HP:0011103)2.23090354
77Abnormality of the anterior horn cell (HP:0006802)2.22114612
78Degeneration of anterior horn cells (HP:0002398)2.22114612
79Lymphoma (HP:0002665)2.21454954
80Acute lymphatic leukemia (HP:0006721)2.20532062
81Congenital stationary night blindness (HP:0007642)2.20130800
82Recurrent abscess formation (HP:0002722)2.19644194
83Reduced antithrombin III activity (HP:0001976)2.19501226
84Congenital, generalized hypertrichosis (HP:0004540)2.19407946
85Chronic diarrhea (HP:0002028)2.19305842
86Muscle hypertrophy of the lower extremities (HP:0008968)2.19101809
87Palpitations (HP:0001962)2.18840719
88Abnormality of the preputium (HP:0100587)2.16953769
89Abnormal mitochondria in muscle tissue (HP:0008316)2.16666782
90Renal Fanconi syndrome (HP:0001994)2.16666546
91Abnormality of chromosome stability (HP:0003220)2.16036959
92Biliary tract neoplasm (HP:0100574)2.14979264
93Abnormality of secondary sexual hair (HP:0009888)2.13849693
94Abnormality of the axillary hair (HP:0100134)2.13849693
95Increased intramyocellular lipid droplets (HP:0012240)2.13102357
96Myelodysplasia (HP:0002863)2.12244457
97Eczematoid dermatitis (HP:0000976)2.10717259
98Abnormal biliary tract morphology (HP:0012440)2.09859368
99Disinhibition (HP:0000734)2.09374157
100Chronic otitis media (HP:0000389)2.09192225
101Recurrent fungal infections (HP:0002841)2.07816382
102Increased circulating renin level (HP:0000848)2.07484483
103Dyschromatopsia (HP:0007641)2.06380373
104Multiple enchondromatosis (HP:0005701)2.05378414
105Trismus (HP:0000211)2.05303347
106Long clavicles (HP:0000890)2.05291485
107Spontaneous hematomas (HP:0007420)2.03130044
108Hypoglycemic coma (HP:0001325)2.02000963
109Poikiloderma (HP:0001029)2.01838431
110Amaurosis fugax (HP:0100576)2.00142994
111Hematochezia (HP:0002573)1.99867827
112Pustule (HP:0200039)1.99543149
113Hypoplasia of the fovea (HP:0007750)1.99247623
114Aplasia/Hypoplasia of the fovea (HP:0008060)1.99247623
115Proximal tubulopathy (HP:0000114)1.99024101
116Exercise intolerance (HP:0003546)1.98203736
117Constricted visual fields (HP:0001133)1.97459172
118Abnormality of chloride homeostasis (HP:0011422)1.95651020
119Morphological abnormality of the inner ear (HP:0011390)1.95471833
120Atrioventricular block (HP:0001678)1.94706340
121Recurrent bacterial skin infections (HP:0005406)1.94413282
122Absent thumb (HP:0009777)1.94297051
123Progressive macrocephaly (HP:0004481)1.93472616
124Gonadal dysgenesis (HP:0000133)1.93057732
125Asplenia (HP:0001746)1.91671680
126Abnormality of eosinophils (HP:0001879)1.91299161
127Autoimmune hemolytic anemia (HP:0001890)1.90743230
128Vacuolated lymphocytes (HP:0001922)1.90679524
129Increased muscle lipid content (HP:0009058)1.89947581
130Metaphyseal dysplasia (HP:0100255)1.89769390
131Palmar hyperkeratosis (HP:0010765)1.89400587
132Hyperventilation (HP:0002883)1.88831836
133Selective tooth agenesis (HP:0001592)1.88786280
134Panhypogammaglobulinemia (HP:0003139)1.88430332
135Abnormal rod and cone electroretinograms (HP:0008323)1.88142040
136Agnosia (HP:0010524)1.87917709
137Bundle branch block (HP:0011710)1.87687314
138Hemoptysis (HP:0002105)1.87484148
139Hypokalemic alkalosis (HP:0001949)1.87237859
140Hyperactive renin-angiotensin system (HP:0000841)1.86551468
141Short middle phalanx of the 5th finger (HP:0004220)1.86396121
142Bone marrow hypocellularity (HP:0005528)1.86120131
143Acute encephalopathy (HP:0006846)1.85342173
1443-Methylglutaconic aciduria (HP:0003535)1.83895850
145Meckel diverticulum (HP:0002245)1.83171853
146IgG deficiency (HP:0004315)1.82971189
147Aplasia/Hypoplasia of the thymus (HP:0010515)1.82396377
148Severe visual impairment (HP:0001141)1.81247834
149Pancytopenia (HP:0001876)1.80556663
150Triphalangeal thumb (HP:0001199)1.79859674
151Palmoplantar hyperkeratosis (HP:0000972)1.79369546
152Cystic hygroma (HP:0000476)1.79364080
153Abnormality of T cells (HP:0002843)1.79288313
154Poor head control (HP:0002421)1.79215530
155Fair hair (HP:0002286)1.78405093
156Systemic lupus erythematosus (HP:0002725)1.77814028
157Squamous cell carcinoma (HP:0002860)1.76324355
158Abnormality of the ileum (HP:0001549)1.76155654
159Neoplasm of the tracheobronchial system (HP:0100552)1.75982565
160Glossoptosis (HP:0000162)1.74912352
161Abnormality of salivation (HP:0100755)1.74465467
162Periodontitis (HP:0000704)1.74302987
163Cellular immunodeficiency (HP:0005374)1.74069637
164Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.73858502
165Depressed nasal ridge (HP:0000457)1.73491428
166Ventricular fibrillation (HP:0001663)1.72711700
167Hamartoma of the eye (HP:0010568)1.72592116
168Severe combined immunodeficiency (HP:0004430)1.72132140
169Entropion (HP:0000621)1.71225856
170Popliteal pterygium (HP:0009756)1.70832740
171Chronic obstructive pulmonary disease (HP:0006510)1.70682605
172Obstructive lung disease (HP:0006536)1.70682605
173Abnormal trabecular bone morphology (HP:0100671)1.70402907
174Amniotic constriction ring (HP:0009775)1.69991645
175Abnormality of placental membranes (HP:0011409)1.69991645
176Abnormal delayed hypersensitivity skin test (HP:0002963)1.69781501
177Aplasia/Hypoplasia of the spleen (HP:0010451)1.68663547
178Neoplasm of the rectum (HP:0100743)1.68054113
179Syncope (HP:0001279)1.67049744
180Widely spaced teeth (HP:0000687)1.66713520
181Meningitis (HP:0001287)1.66655818
182Orchitis (HP:0100796)1.66077850
183Nemaline bodies (HP:0003798)1.65825281
184Abnormality of the fovea (HP:0000493)1.64797008
185Cheilitis (HP:0100825)1.64470353
186Recurrent bronchitis (HP:0002837)1.64249886
187Missing ribs (HP:0000921)1.64241269
188Petechiae (HP:0000967)1.61558008
189Cellulitis (HP:0100658)1.60896023
190Abnormal protein glycosylation (HP:0012346)1.60452013
191Abnormal glycosylation (HP:0012345)1.60452013
192Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.60452013
193Abnormal protein N-linked glycosylation (HP:0012347)1.60452013
194Cutaneous melanoma (HP:0012056)1.60301040
195Sparse scalp hair (HP:0002209)1.58787946
196Dry hair (HP:0011359)1.58039101

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME24.22283511
2STK162.98992130
3TAOK32.73691762
4WEE12.69192347
5PASK2.56572104
6MST42.48598261
7BUB12.42487972
8PIM22.20247440
9MAP3K122.14139325
10RPS6KB22.10268076
11VRK12.07960007
12STK242.07776675
13SRPK12.01543396
14MAP3K21.98697329
15MAP4K21.95017284
16RPS6KA41.94922232
17EIF2AK11.92622499
18CDC71.92169801
19TESK21.84166797
20TGFBR11.81666310
21LRRK21.65016972
22TEC1.64894556
23EIF2AK31.61725606
24BRSK21.57862029
25STK391.56706687
26OXSR11.54025490
27MAP4K11.52877654
28TESK11.52675308
29ERBB31.52322728
30PINK11.51363756
31TLK11.51169008
32ACVR1B1.50809290
33BTK1.49230350
34MKNK11.48856659
35NUAK11.45685827
36STK101.43968437
37BMPR21.43325073
38FES1.42762972
39IRAK41.40981586
40CAMKK21.40916495
41PAK41.39952821
42RIPK41.39546571
43AURKB1.34342358
44JAK11.31996447
45FLT31.30323420
46BRD41.29580670
47TSSK61.29146742
48SCYL21.29119655
49MATK1.27815110
50LIMK11.24362384
51ILK1.22731311
52PLK41.22244898
53SGK21.21791062
54DYRK31.21613732
55STK38L1.20684828
56KDR1.20672981
57TNIK1.19837471
58TXK1.18233118
59FGFR31.17828069
60BLK1.14741641
61STK31.11671000
62MAP3K141.10554170
63EPHA21.10316342
64MAPK71.09245640
65PIM11.07898537
66NEK61.07690571
67MAPK121.07005020
68PBK1.06000405
69EEF2K1.04764837
70PLK11.01494907
71MAP2K60.99875053
72CASK0.98651805
73CDK70.97449779
74NME10.97300024
75ZAP700.96760783
76AKT30.95498769
77NEK10.93237752
78NEK90.93209564
79PLK30.92877913
80YES10.92791314
81CDK30.92578814
82NEK20.92359630
83MAP3K80.92291352
84LATS10.91820860
85MKNK20.91650813
86ZAK0.91393850
87ATR0.89331565
88EIF2AK20.88423026
89EPHA40.87669771
90BCKDK0.87331865
91IRAK30.87280982
92DAPK20.85523291
93MAP2K30.85375954
94STK40.84532285
95CSF1R0.83658286
96CCNB10.83482055
97PIK3CA0.83283957
98TTK0.80878818
99MAP3K60.77911474
100SIK30.76962129
101DMPK0.75316986
102TRPM70.74346726
103MAPKAPK30.74198838
104CLK10.72905678
105CDK60.72860968
106WNK10.72199944
107HCK0.71949088
108ITK0.71563852
109NLK0.71546438
110PRKCQ0.70485832
111TIE10.70112690
112TYK20.68769769
113PRKG20.66552757
114SGK10.66139781
115TGFBR20.65601064
116CDK80.65272770
117PAK30.64750295
118PRKCE0.64006873
119BMPR1B0.63678087
120CDK40.63494892
121CSNK2A10.63247890
122CSNK2A20.63205395
123KIT0.62087234
124PDK20.61923050
125ERN10.61795165
126RPS6KB10.60907466
127JAK20.60349734
128FGFR20.59933314
129JAK30.59107595
130IKBKB0.58973523
131CSK0.58486170
132AURKA0.58365932
133GRK60.57662856
134SYK0.57590273
135WNK30.57455387
136TBK10.57274566
137MYLK0.56409068
138PRKG10.55947769
139CSNK1G20.54918839
140PRKAA20.54718159
141SGK30.54376361
142IRAK10.53620373
143MAP3K50.53359253
144MAP3K30.52963972
145PRKCI0.52822831
146MAP2K40.52704788
147DYRK20.51958480
148PIK3CG0.51936369
149RPS6KA50.51620230
150LYN0.50350736
151MAP3K100.50164099
152LCK0.49811727
153CSNK1G10.49157792
154BRSK10.48683773
155PAK10.48587459
156IGF1R0.48392165
157FRK0.47398031
158RPS6KA60.47118911
159ADRBK20.47013114
160SGK2230.46506706
161SGK4940.46506706
162IKBKE0.45226976
163CDK190.44686660
164RPS6KL10.44025687
165RPS6KC10.44025687
166OBSCN0.43681675
167PAK20.43632738

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.45291595
2DNA replication_Homo sapiens_hsa030304.22590502
3Asthma_Homo sapiens_hsa053103.74379137
4Proteasome_Homo sapiens_hsa030503.62034078
5Mismatch repair_Homo sapiens_hsa034303.41942769
6Spliceosome_Homo sapiens_hsa030402.78913035
7Staphylococcus aureus infection_Homo sapiens_hsa051502.76225942
8RNA polymerase_Homo sapiens_hsa030202.75056703
9Type I diabetes mellitus_Homo sapiens_hsa049402.54728373
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.38782907
11Base excision repair_Homo sapiens_hsa034102.36948047
12Pyrimidine metabolism_Homo sapiens_hsa002402.31993204
13Autoimmune thyroid disease_Homo sapiens_hsa053202.30706201
14Nucleotide excision repair_Homo sapiens_hsa034202.30371180
15Protein export_Homo sapiens_hsa030602.21478976
16Homologous recombination_Homo sapiens_hsa034402.19708560
17Renin secretion_Homo sapiens_hsa049242.14225940
18Non-homologous end-joining_Homo sapiens_hsa034502.13215670
19RNA transport_Homo sapiens_hsa030132.03667344
20One carbon pool by folate_Homo sapiens_hsa006701.97378607
21Linoleic acid metabolism_Homo sapiens_hsa005911.90528198
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.85160657
23Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.74732424
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.71559102
25Cell cycle_Homo sapiens_hsa041101.67111654
26Oxidative phosphorylation_Homo sapiens_hsa001901.63059368
27Caffeine metabolism_Homo sapiens_hsa002321.62925133
28Parkinsons disease_Homo sapiens_hsa050121.60098905
29Circadian rhythm_Homo sapiens_hsa047101.60021412
30alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.57636064
31RNA degradation_Homo sapiens_hsa030181.53160651
32Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.50724175
33Histidine metabolism_Homo sapiens_hsa003401.48927618
34p53 signaling pathway_Homo sapiens_hsa041151.47215517
35Fanconi anemia pathway_Homo sapiens_hsa034601.45214573
36Pancreatic secretion_Homo sapiens_hsa049721.40351254
37Platelet activation_Homo sapiens_hsa046111.37507801
38Mineral absorption_Homo sapiens_hsa049781.37406128
39Ether lipid metabolism_Homo sapiens_hsa005651.31525632
40Retinol metabolism_Homo sapiens_hsa008301.27308289
41Antigen processing and presentation_Homo sapiens_hsa046121.24993291
42Steroid hormone biosynthesis_Homo sapiens_hsa001401.23029311
43Primary immunodeficiency_Homo sapiens_hsa053401.20506982
44Huntingtons disease_Homo sapiens_hsa050161.17981492
45Propanoate metabolism_Homo sapiens_hsa006401.16589151
46Renin-angiotensin system_Homo sapiens_hsa046141.14729078
47Basal transcription factors_Homo sapiens_hsa030221.12031450
48Serotonergic synapse_Homo sapiens_hsa047261.10854951
49Purine metabolism_Homo sapiens_hsa002301.07962582
50Legionellosis_Homo sapiens_hsa051341.07448191
51Glutathione metabolism_Homo sapiens_hsa004801.06024509
52Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.04809080
53Tryptophan metabolism_Homo sapiens_hsa003801.04155831
54Taste transduction_Homo sapiens_hsa047421.04148157
55Butanoate metabolism_Homo sapiens_hsa006501.03470045
56Sulfur metabolism_Homo sapiens_hsa009201.03181480
57Systemic lupus erythematosus_Homo sapiens_hsa053221.02248916
58Epstein-Barr virus infection_Homo sapiens_hsa051691.00572680
59Alzheimers disease_Homo sapiens_hsa050100.99937199
60Cyanoamino acid metabolism_Homo sapiens_hsa004600.99305333
61Regulation of autophagy_Homo sapiens_hsa041400.98422884
62Salivary secretion_Homo sapiens_hsa049700.97638853
63Herpes simplex infection_Homo sapiens_hsa051680.94897677
64mRNA surveillance pathway_Homo sapiens_hsa030150.92777333
65Tuberculosis_Homo sapiens_hsa051520.92254224
66Vascular smooth muscle contraction_Homo sapiens_hsa042700.91456373
67Pentose phosphate pathway_Homo sapiens_hsa000300.90816313
68Dorso-ventral axis formation_Homo sapiens_hsa043200.88957429
69Nicotine addiction_Homo sapiens_hsa050330.88579058
70Circadian entrainment_Homo sapiens_hsa047130.88316048
71Collecting duct acid secretion_Homo sapiens_hsa049660.86515724
72Peroxisome_Homo sapiens_hsa041460.84353406
73Viral myocarditis_Homo sapiens_hsa054160.84229673
74Other glycan degradation_Homo sapiens_hsa005110.84068931
75Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.83867350
76Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.82147859
77Long-term potentiation_Homo sapiens_hsa047200.82133088
78Rheumatoid arthritis_Homo sapiens_hsa053230.81772672
79Maturity onset diabetes of the young_Homo sapiens_hsa049500.79021374
80Phosphatidylinositol signaling system_Homo sapiens_hsa040700.78448060
81cGMP-PKG signaling pathway_Homo sapiens_hsa040220.78241027
82Fatty acid degradation_Homo sapiens_hsa000710.77626281
83Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.77189813
84Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.77079898
85Amphetamine addiction_Homo sapiens_hsa050310.77040511
86Oxytocin signaling pathway_Homo sapiens_hsa049210.76494183
87Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.76338703
88Starch and sucrose metabolism_Homo sapiens_hsa005000.76170866
89Measles_Homo sapiens_hsa051620.75055400
90Gastric acid secretion_Homo sapiens_hsa049710.74960824
91Thyroid cancer_Homo sapiens_hsa052160.74769785
92Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.74623891
93Leishmaniasis_Homo sapiens_hsa051400.73517958
94Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.73285509
95Inositol phosphate metabolism_Homo sapiens_hsa005620.73032731
96Hematopoietic cell lineage_Homo sapiens_hsa046400.71599350
97NF-kappa B signaling pathway_Homo sapiens_hsa040640.71228513
98Vitamin digestion and absorption_Homo sapiens_hsa049770.70493702
99Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.69897894
100Intestinal immune network for IgA production_Homo sapiens_hsa046720.69844072
101Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.69262916
102Calcium signaling pathway_Homo sapiens_hsa040200.68762769
103Folate biosynthesis_Homo sapiens_hsa007900.68615891
104Long-term depression_Homo sapiens_hsa047300.68571455
105Shigellosis_Homo sapiens_hsa051310.67418982
106Drug metabolism - other enzymes_Homo sapiens_hsa009830.67377449
107Cardiac muscle contraction_Homo sapiens_hsa042600.67224421
108Viral carcinogenesis_Homo sapiens_hsa052030.66821282
109Morphine addiction_Homo sapiens_hsa050320.66409584
110Primary bile acid biosynthesis_Homo sapiens_hsa001200.66186282
111GABAergic synapse_Homo sapiens_hsa047270.66141724
112Fat digestion and absorption_Homo sapiens_hsa049750.65886523
113Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.63898817
114Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61046613
115Sphingolipid metabolism_Homo sapiens_hsa006000.59754100
116Insulin secretion_Homo sapiens_hsa049110.58220299
117RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.58078885
118HTLV-I infection_Homo sapiens_hsa051660.57177441
119N-Glycan biosynthesis_Homo sapiens_hsa005100.56818477
120Sulfur relay system_Homo sapiens_hsa041220.56813180
121Apoptosis_Homo sapiens_hsa042100.56697810
122Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.55141564
123Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.54039070
124Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.53009981
125GnRH signaling pathway_Homo sapiens_hsa049120.52590728
126Pertussis_Homo sapiens_hsa051330.52512728
127Chemokine signaling pathway_Homo sapiens_hsa040620.51833602
128Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.50945256
129Leukocyte transendothelial migration_Homo sapiens_hsa046700.50243494
130African trypanosomiasis_Homo sapiens_hsa051430.49633732
131Cholinergic synapse_Homo sapiens_hsa047250.48621369
132NOD-like receptor signaling pathway_Homo sapiens_hsa046210.48604754
133Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48212341
134Carbohydrate digestion and absorption_Homo sapiens_hsa049730.47968307
135Toxoplasmosis_Homo sapiens_hsa051450.47620004
136Dopaminergic synapse_Homo sapiens_hsa047280.47564139
137Hepatitis B_Homo sapiens_hsa051610.47320194
138Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.47076286
139Glutamatergic synapse_Homo sapiens_hsa047240.46708045
140Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.46663662
141Small cell lung cancer_Homo sapiens_hsa052220.45649073
142Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.44827056
143Graft-versus-host disease_Homo sapiens_hsa053320.44412694
144Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.43246093
145Fatty acid elongation_Homo sapiens_hsa000620.42929513
146Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.41640736
147SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40775344
148Biosynthesis of amino acids_Homo sapiens_hsa012300.40068277
149Chemical carcinogenesis_Homo sapiens_hsa052040.38771424
150Galactose metabolism_Homo sapiens_hsa000520.38732030
151MicroRNAs in cancer_Homo sapiens_hsa052060.38665895
152Pentose and glucuronate interconversions_Homo sapiens_hsa000400.35565564
153Influenza A_Homo sapiens_hsa051640.35324488
154Arachidonic acid metabolism_Homo sapiens_hsa005900.34973768
155Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.34728316
156Cysteine and methionine metabolism_Homo sapiens_hsa002700.34288751
157Bladder cancer_Homo sapiens_hsa052190.30871133
158Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.30843590
159Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.30637149
160Carbon metabolism_Homo sapiens_hsa012000.30512497
161Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.30007480
162Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.28140411
163Metabolic pathways_Homo sapiens_hsa011000.27725548
164B cell receptor signaling pathway_Homo sapiens_hsa046620.26703625
165Acute myeloid leukemia_Homo sapiens_hsa052210.26181249
166Allograft rejection_Homo sapiens_hsa053300.25111527
167Salmonella infection_Homo sapiens_hsa051320.24055131
168Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.23542387
169Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.23305278
170Jak-STAT signaling pathway_Homo sapiens_hsa046300.22933171
171Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.22529851
172Selenocompound metabolism_Homo sapiens_hsa004500.21281912
173Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.19643655
174HIF-1 signaling pathway_Homo sapiens_hsa040660.19526945
175Malaria_Homo sapiens_hsa051440.18974714

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