VPS39

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that may promote clustering and fusion of late endosomes and lysosomes. The protein may also act as an adaptor protein that modulates the transforming growth factor-beta response by coupling the transforming growth factor-beta receptor complex to the Smad pathway. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)4.35476964
2regulation of short-term neuronal synaptic plasticity (GO:0048172)4.22162094
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.02819707
4antigen processing and presentation of endogenous antigen (GO:0019883)3.88774878
5proline transport (GO:0015824)3.86867794
6antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.79660159
7locomotory exploration behavior (GO:0035641)3.77278941
8cerebellar Purkinje cell differentiation (GO:0021702)3.69260331
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.65915239
10synaptic vesicle exocytosis (GO:0016079)3.59613416
11positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.53081104
12regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.45220838
13antigen processing and presentation via MHC class Ib (GO:0002475)3.38237698
14mannose metabolic process (GO:0006013)3.37442755
15positive regulation of gamma-delta T cell activation (GO:0046645)3.28713837
16regulation of synaptic vesicle exocytosis (GO:2000300)3.28099827
17regulation of glutamate receptor signaling pathway (GO:1900449)3.27216078
18synaptic vesicle endocytosis (GO:0048488)3.16568852
19regulation of synaptic vesicle transport (GO:1902803)3.15975349
20glutamate secretion (GO:0014047)3.13296912
21synaptic vesicle docking involved in exocytosis (GO:0016081)3.13057831
22regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.12121230
23modulation by symbiont of host immune response (GO:0052553)3.09302394
24positive regulation by symbiont of host defense response (GO:0052509)3.09302394
25modulation by symbiont of host defense response (GO:0052031)3.09302394
26modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.09302394
27modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.09302394
28positive regulation by organism of defense response of other organism involved in symbiotic interact3.09302394
29nerve growth factor signaling pathway (GO:0038180)3.08464334
30protein localization to synapse (GO:0035418)3.05057575
31positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.04579589
32detection of other organism (GO:0098543)3.03928751
33membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.02523883
34regulation of synapse structural plasticity (GO:0051823)3.01822401
35negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.99312468
36daunorubicin metabolic process (GO:0044597)2.97447358
37polyketide metabolic process (GO:0030638)2.97447358
38doxorubicin metabolic process (GO:0044598)2.97447358
39cellular potassium ion homeostasis (GO:0030007)2.97210611
40response to muramyl dipeptide (GO:0032495)2.95222897
41regulation of ARF protein signal transduction (GO:0032012)2.95052173
42negative regulation of cell killing (GO:0031342)2.94646316
43negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.94646316
44detection of bacterium (GO:0016045)2.94483377
45ionotropic glutamate receptor signaling pathway (GO:0035235)2.91720105
46synaptic transmission, glutamatergic (GO:0035249)2.91036774
47regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.91026098
48regulation of gamma-delta T cell activation (GO:0046643)2.88457911
49vocalization behavior (GO:0071625)2.88112756
50phosphatidylinositol dephosphorylation (GO:0046856)2.86180387
51B cell receptor signaling pathway (GO:0050853)2.83251567
52neurotransmitter secretion (GO:0007269)2.82335584
53response to auditory stimulus (GO:0010996)2.80791643
54cellular extravasation (GO:0045123)2.80085153
55stress fiber assembly (GO:0043149)2.78716673
56regulation of Rap GTPase activity (GO:0032317)2.78374336
57exploration behavior (GO:0035640)2.77571046
58positive regulation of Rap GTPase activity (GO:0032854)2.74967742
59macrophage activation involved in immune response (GO:0002281)2.72961795
60positive thymic T cell selection (GO:0045059)2.72270303
61histone H3-K4 trimethylation (GO:0080182)2.71880664
62regulation of gamma-delta T cell differentiation (GO:0045586)2.70785845
63neurotransmitter-gated ion channel clustering (GO:0072578)2.70525089
64germinal center formation (GO:0002467)2.70081144
65activation of protein kinase A activity (GO:0034199)2.69705537
66regulation of B cell receptor signaling pathway (GO:0050855)2.68180532
67sodium ion export (GO:0071436)2.67764837
68auditory behavior (GO:0031223)2.64954002
69negative T cell selection (GO:0043383)2.63970069
70regulation of long-term neuronal synaptic plasticity (GO:0048169)2.63850882
71regulation of neuronal synaptic plasticity (GO:0048168)2.63808694
72neuron-neuron synaptic transmission (GO:0007270)2.62311319
73response to laminar fluid shear stress (GO:0034616)2.61035382
74regulation of T-helper 2 cell differentiation (GO:0045628)2.59948394
75detection of external biotic stimulus (GO:0098581)2.59363962
76glutamate receptor signaling pathway (GO:0007215)2.59232821
77neuron cell-cell adhesion (GO:0007158)2.57954053
78positive regulation of synapse maturation (GO:0090129)2.57842927
79regulation of glycogen (starch) synthase activity (GO:2000465)2.55265192
80phospholipid dephosphorylation (GO:0046839)2.54265634
81thymic T cell selection (GO:0045061)2.53851332
82barbed-end actin filament capping (GO:0051016)2.53357154
83negative regulation of lymphocyte mediated immunity (GO:0002707)2.50107333
84negative regulation of erythrocyte differentiation (GO:0045647)2.48663790
85mitochondrion distribution (GO:0048311)2.48292456
86vesicle transport along microtubule (GO:0047496)2.47791580
87leukocyte aggregation (GO:0070486)2.46577912
88histone H3-K36 demethylation (GO:0070544)2.45778152
89neutrophil activation involved in immune response (GO:0002283)2.45181058
90negative regulation of type 2 immune response (GO:0002829)2.45041168
91positive regulation of synaptic transmission, GABAergic (GO:0032230)2.44279613
92negative regulation of leukocyte mediated immunity (GO:0002704)2.43981444
93antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.43025823
94negative regulation of cytosolic calcium ion concentration (GO:0051481)2.41694209
95regulation of excitatory postsynaptic membrane potential (GO:0060079)2.41416775
96G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.40927107
97signal complex assembly (GO:0007172)2.40883869
98regulation of leukocyte degranulation (GO:0043300)2.40698634
99long-term memory (GO:0007616)2.40414280
100detection of molecule of bacterial origin (GO:0032490)2.40324732
101dendritic spine morphogenesis (GO:0060997)2.39788968
102regulation of ARF GTPase activity (GO:0032312)2.39161632
103positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.38875497
104membrane depolarization during action potential (GO:0086010)2.37613899
105response to peptidoglycan (GO:0032494)2.37199603
106positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.37095333
107regulation of macrophage cytokine production (GO:0010935)2.36484442
108positive regulation of cellular amide metabolic process (GO:0034250)2.36050182
109T cell selection (GO:0045058)2.35270426
110long-term synaptic potentiation (GO:0060291)2.34693526
111positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.33574398
112regulation of synaptic transmission, glutamatergic (GO:0051966)2.32977005
113cell differentiation in hindbrain (GO:0021533)2.32743885
114regulation of postsynaptic membrane potential (GO:0060078)2.31572592
115G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.30560365
116NIK/NF-kappaB signaling (GO:0038061)2.29953609
117positive regulation of histone deacetylation (GO:0031065)2.29864800
118inositol phosphate catabolic process (GO:0071545)2.29786998
119response to interleukin-15 (GO:0070672)2.29593742
120regulation of synapse maturation (GO:0090128)2.29253030
121positive T cell selection (GO:0043368)2.27378478
122cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.27223333
123positive regulation of membrane potential (GO:0045838)2.27149040
124neurotransmitter transport (GO:0006836)2.27076802
125dendrite morphogenesis (GO:0048813)2.27012588
126protein localization to endosome (GO:0036010)2.26890148
127regulation of NFAT protein import into nucleus (GO:0051532)2.25733614
128response to host (GO:0075136)2.25549643
129response to host defenses (GO:0052200)2.25549643
130response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.25549643
131inositol phosphate dephosphorylation (GO:0046855)2.25471458
132phosphorylated carbohydrate dephosphorylation (GO:0046838)2.25471458
133negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.24803761
134Golgi to endosome transport (GO:0006895)2.24517546
135detection of biotic stimulus (GO:0009595)2.24192750
136positive regulation of receptor recycling (GO:0001921)2.23071433
137potassium ion homeostasis (GO:0055075)2.23028550
138cell communication by electrical coupling (GO:0010644)2.22880620
139negative thymic T cell selection (GO:0045060)2.22866273
140dopamine receptor signaling pathway (GO:0007212)2.22434744
141regulation of myeloid leukocyte mediated immunity (GO:0002886)2.21430535
142regulation of neurotransmitter secretion (GO:0046928)2.20455394
143regulation of interferon-beta biosynthetic process (GO:0045357)2.20008130
144membrane hyperpolarization (GO:0060081)2.19759690
145alanine transport (GO:0032328)2.19251735
146mechanosensory behavior (GO:0007638)2.19245122
147membrane depolarization (GO:0051899)2.19181303
148negative regulation of toll-like receptor signaling pathway (GO:0034122)2.18746514
149positive regulation of B cell differentiation (GO:0045579)2.18656887
150embryonic process involved in female pregnancy (GO:0060136)2.18288174
151striatum development (GO:0021756)2.18046914
152negative regulation of granulocyte differentiation (GO:0030853)2.17900545
153regulation of synaptic plasticity (GO:0048167)2.17765075
154regulation of regulated secretory pathway (GO:1903305)2.17068505
155maintenance of protein location in nucleus (GO:0051457)2.16754566
156response to pheromone (GO:0019236)2.16570190
157T cell migration (GO:0072678)2.16330258
158regulation of vesicle fusion (GO:0031338)2.15760244
159Arp2/3 complex-mediated actin nucleation (GO:0034314)2.15691161
160positive regulation of gene expression, epigenetic (GO:0045815)2.15498508
161regulation of dendritic cell antigen processing and presentation (GO:0002604)2.15446104
162regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.15145989
163central nervous system projection neuron axonogenesis (GO:0021952)2.14819342
164regulation of type 2 immune response (GO:0002828)2.14528813
165negative regulation of T cell mediated immunity (GO:0002710)2.14103047
166regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.14052444
167negative regulation of glycoprotein biosynthetic process (GO:0010561)2.12001871
168cellular response to monoamine stimulus (GO:0071868)2.11693868
169cellular response to catecholamine stimulus (GO:0071870)2.11693868
170positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.11466770
171regulation of mast cell degranulation (GO:0043304)2.11353475
172response to host immune response (GO:0052572)2.10282933
173response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.10282933
174negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.10253435
175Golgi transport vesicle coating (GO:0048200)2.08947978
176COPI coating of Golgi vesicle (GO:0048205)2.08947978
177immunoglobulin mediated immune response (GO:0016064)2.08373895
178activation of JUN kinase activity (GO:0007257)2.07774544
179positive regulation of macrophage cytokine production (GO:0060907)2.07524547
180cellular response to epinephrine stimulus (GO:0071872)2.06608339
181negative regulation of dendrite morphogenesis (GO:0050774)2.06468076
182actin filament polymerization (GO:0030041)2.06224974
183regulation of lipid kinase activity (GO:0043550)2.04111035
184negative regulation of T-helper cell differentiation (GO:0045623)2.04104612
185negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.04104612
186type I interferon signaling pathway (GO:0060337)2.02245777
187cellular response to type I interferon (GO:0071357)2.02245777
188positive regulation of type 2 immune response (GO:0002830)2.01812640
189regulation of granulocyte differentiation (GO:0030852)2.01298674
190response to type I interferon (GO:0034340)2.01029176
191regulation of extracellular matrix disassembly (GO:0010715)2.00650683

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.22037522
2THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.14421219
3GBX2_23144817_ChIP-Seq_PC3_Human2.84887869
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.71282042
5DROSHA_22980978_ChIP-Seq_HELA_Human2.61364565
6VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.57140792
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.51565430
8ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.44534395
9BP1_19119308_ChIP-ChIP_Hs578T_Human2.43890050
10VDR_21846776_ChIP-Seq_THP-1_Human2.24073505
11RARB_27405468_Chip-Seq_BRAIN_Mouse2.15658116
12LXR_22292898_ChIP-Seq_THP-1_Human2.15210294
13SMAD_19615063_ChIP-ChIP_OVARY_Human2.13053229
14KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.11750788
15SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.10685975
16MYC_22102868_ChIP-Seq_BL_Human2.09195044
17EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.08776410
18EGR1_19374776_ChIP-ChIP_THP-1_Human2.02581516
19REST_21632747_ChIP-Seq_MESCs_Mouse1.98270690
20ELK3_25401928_ChIP-Seq_HUVEC_Human1.94795529
21JARID2_20064375_ChIP-Seq_MESCs_Mouse1.93935979
22IKZF1_21737484_ChIP-ChIP_HCT116_Human1.91901129
23SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.88302013
24NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.87535349
25SCL_19346495_ChIP-Seq_HPC-7_Human1.82813813
26SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.81003300
27VDR_24763502_ChIP-Seq_THP-1_Human1.79862798
28NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.78073518
29RNF2_18974828_ChIP-Seq_MESCs_Mouse1.75709449
30EZH2_18974828_ChIP-Seq_MESCs_Mouse1.75709449
31RARG_19884340_ChIP-ChIP_MEFs_Mouse1.74877407
32REST_18959480_ChIP-ChIP_MESCs_Mouse1.73432592
33MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.72286939
34MTF2_20144788_ChIP-Seq_MESCs_Mouse1.72201673
35RNF2_27304074_Chip-Seq_ESCs_Mouse1.71356440
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.70384635
37AR_21572438_ChIP-Seq_LNCaP_Human1.67067170
38KDM2B_26808549_Chip-Seq_JURKAT_Human1.67064673
39SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.66707057
40JARID2_20075857_ChIP-Seq_MESCs_Mouse1.66106621
41MAF_26560356_Chip-Seq_TH1_Human1.62902717
42SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.61130296
43RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.58613294
44SUZ12_27294783_Chip-Seq_ESCs_Mouse1.57905228
45ZFP281_18757296_ChIP-ChIP_E14_Mouse1.57837572
46MYB_21317192_ChIP-Seq_ERMYB_Mouse1.55845067
47RUNX1_22412390_ChIP-Seq_EML_Mouse1.52318951
48TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.50241348
49IRF8_22096565_ChIP-ChIP_GC-B_Human1.50095205
50CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.49030412
51TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.48296269
52UTX_26944678_Chip-Seq_JUKART_Human1.48225973
53KDM2B_26808549_Chip-Seq_SUP-B15_Human1.48197941
54EZH2_27294783_Chip-Seq_ESCs_Mouse1.47849471
55SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.47842317
56EZH2_27304074_Chip-Seq_ESCs_Mouse1.46899503
57SPI1_23127762_ChIP-Seq_K562_Human1.43462253
58SMAD4_21799915_ChIP-Seq_A2780_Human1.42501500
59TP63_17297297_ChIP-ChIP_HaCaT_Human1.42056309
60MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.39805607
61GATA1_22025678_ChIP-Seq_K562_Human1.39576827
62BRD4_27068464_Chip-Seq_AML-cells_Mouse1.39546940
63IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.37040569
64PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.35382132
65TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34564931
66RACK7_27058665_Chip-Seq_MCF-7_Human1.33336344
67GATA1_19941826_ChIP-Seq_K562_Human1.33295466
68RUNX_20019798_ChIP-Seq_JUKART_Human1.31166408
69EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.31099396
70MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.30912570
71ESR2_21235772_ChIP-Seq_MCF-7_Human1.29658856
72STAT3_23295773_ChIP-Seq_U87_Human1.29306993
73TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.29123936
74CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.28797152
75MAF_26560356_Chip-Seq_TH2_Human1.27940598
76KDM2B_26808549_Chip-Seq_K562_Human1.27771554
77* AR_19668381_ChIP-Seq_PC3_Human1.26542699
78* SOX2_21211035_ChIP-Seq_LN229_Gbm1.26395787
79GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.25239151
80RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.21859618
81WT1_25993318_ChIP-Seq_PODOCYTE_Human1.21078925
82CLOCK_20551151_ChIP-Seq_293T_Human1.19783075
83ZNF217_24962896_ChIP-Seq_MCF-7_Human1.19172484
84RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.19013454
85SMC4_20622854_ChIP-Seq_HELA_Human1.18715038
86SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18624952
87P53_22127205_ChIP-Seq_FIBROBLAST_Human1.18609909
88DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.17948913
89CTCF_27219007_Chip-Seq_ERYTHROID_Human1.17274313
90TCF7_22412390_ChIP-Seq_EML_Mouse1.17154297
91TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16188927
92POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.16188927
93FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.15635400
94ARNT_22903824_ChIP-Seq_MCF-7_Human1.15391274
95GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13294333
96TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.13215109
97STAT6_21828071_ChIP-Seq_BEAS2B_Human1.11753256
98TBX20_22328084_ChIP-Seq_HEART_Mouse1.10988609
99TBX20_22080862_ChIP-Seq_HEART_Mouse1.10988609
100Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.10557461
101MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.10040924
102AHR_22903824_ChIP-Seq_MCF-7_Human1.09997623
103P300_27058665_Chip-Seq_ZR-75-30cells_Human1.09913850
104IGF1R_20145208_ChIP-Seq_DFB_Human1.09109953
105FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.08991170
106GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08875301
107IRF8_21731497_ChIP-ChIP_J774_Mouse1.07504837
108SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.06724228
109SA1_27219007_Chip-Seq_ERYTHROID_Human1.06418821
110WT1_19549856_ChIP-ChIP_CCG9911_Human1.06184064
111TCF4_23295773_ChIP-Seq_U87_Human1.05427597
112RNF2_27304074_Chip-Seq_NSC_Mouse1.04690299
113KDM2B_26808549_Chip-Seq_DND41_Human1.03832760
114PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03389726
115* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.03229584
116CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.03074109
117GATA1_19941827_ChIP-Seq_MEL_Mouse1.02848074
118IRF8_27001747_Chip-Seq_BMDM_Mouse1.02561630
119EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.02207192
120NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.02111715
121STAT4_19710469_ChIP-ChIP_TH1__Mouse1.01852303
122CREB1_26743006_Chip-Seq_LNCaP_Human1.01653209
123LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.01612847
124STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.01472368
125SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01284542
126SMAD3_21741376_ChIP-Seq_ESCs_Human1.00857629
127VDR_24787735_ChIP-Seq_THP-1_Human1.00208257
128WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.00082401
129GATA2_21666600_ChIP-Seq_HMVEC_Human0.99710936
130E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.99482621
131YAP1_20516196_ChIP-Seq_MESCs_Mouse0.98642302
132AR_25329375_ChIP-Seq_VCAP_Human0.98321809
133SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.98093063
134KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.97857468
135SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.97604139
136CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.97540090
137GATA1_22383799_ChIP-Seq_G1ME_Mouse0.97150674
138TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.97025362
139ZFP281_27345836_Chip-Seq_ESCs_Mouse0.97006986
140CTNNB1_20460455_ChIP-Seq_HCT116_Human0.96687278
141EED_16625203_ChIP-ChIP_MESCs_Mouse0.96517354
142UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.96070064
143DNAJC2_21179169_ChIP-ChIP_NT2_Human0.94317336
144LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.94166325
145SMC1_22415368_ChIP-Seq_MEFs_Mouse0.93996054
146STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.93210598
147KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.92660113
148P300_19829295_ChIP-Seq_ESCs_Human0.91774025
149MYB_26560356_Chip-Seq_TH2_Human0.91552257
150ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.91328177
151CTBP2_25329375_ChIP-Seq_LNCAP_Human0.90218911
152RING1B_27294783_Chip-Seq_NPCs_Mouse0.90066047
153CTBP1_25329375_ChIP-Seq_LNCAP_Human0.89770964
154PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89585163
155RXR_22108803_ChIP-Seq_LS180_Human0.88447274
156PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.86944091
157TP53_16413492_ChIP-PET_HCT116_Human0.86496846
158TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.86191778
159RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.86176990
160NR3C1_23031785_ChIP-Seq_PC12_Mouse0.85366768

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.56313518
2MP0000569_abnormal_digit_pigmentation4.14269847
3MP0003183_abnormal_peptide_metabolism3.67582947
4MP0003436_decreased_susceptibility_to3.52402318
5MP0003303_peritoneal_inflammation3.03264260
6MP0003724_increased_susceptibility_to2.93289087
7MP0003880_abnormal_central_pattern2.92018285
8MP0005423_abnormal_somatic_nervous2.84700204
9MP0003787_abnormal_imprinting2.81825521
10MP0003635_abnormal_synaptic_transmissio2.78439468
11MP0003300_gastrointestinal_ulcer2.67833304
12MP0001958_emphysema2.50756346
13MP0008961_abnormal_basal_metabolism2.45591167
14MP0003191_abnormal_cellular_cholesterol2.40585840
15MP0002254_reproductive_system_inflammat2.38587312
16MP0003172_abnormal_lysosome_physiology2.36034737
17MP0009046_muscle_twitch2.32078271
18MP0004858_abnormal_nervous_system2.25501608
19MP0002063_abnormal_learning/memory/cond2.15344354
20MP0002064_seizures2.13282837
21MP0005646_abnormal_pituitary_gland2.13217555
22MP0003705_abnormal_hypodermis_morpholog2.12089253
23MP0009278_abnormal_bone_marrow2.05841236
24MP0009745_abnormal_behavioral_response1.99269196
25MP0005464_abnormal_platelet_physiology1.99125942
26MP0003122_maternal_imprinting1.95575684
27MP0003279_aneurysm1.95555274
28MP0003828_pulmonary_edema1.95492087
29MP0008260_abnormal_autophagy1.95401039
30MP0003763_abnormal_thymus_physiology1.95316851
31MP0009840_abnormal_foam_cell1.95175284
32MP0009780_abnormal_chondrocyte_physiolo1.92107200
33MP0001968_abnormal_touch/_nociception1.91931992
34MP0002419_abnormal_innate_immunity1.90244027
35MP0002572_abnormal_emotion/affect_behav1.89030854
36MP0004270_analgesia1.84291655
37MP0008438_abnormal_cutaneous_collagen1.83128801
38MP0001533_abnormal_skeleton_physiology1.82591108
39MP0005645_abnormal_hypothalamus_physiol1.82281120
40MP0004947_skin_inflammation1.77620499
41MP0005000_abnormal_immune_tolerance1.77423338
42MP0003091_abnormal_cell_migration1.76414078
43MP0001486_abnormal_startle_reflex1.74473298
44MP0005394_taste/olfaction_phenotype1.73710729
45MP0005499_abnormal_olfactory_system1.73710729
46MP0005025_abnormal_response_to1.72671532
47MP0003329_amyloid_beta_deposits1.72666521
48MP0002396_abnormal_hematopoietic_system1.70919174
49MP0002909_abnormal_adrenal_gland1.61026433
50MP0002998_abnormal_bone_remodeling1.59171672
51MP0002272_abnormal_nervous_system1.55441152
52MP0005075_abnormal_melanosome_morpholog1.53361526
53MP0008569_lethality_at_weaning1.51064250
54MP0003566_abnormal_cell_adhesion1.50168490
55MP0002405_respiratory_system_inflammati1.48923071
56MP0000604_amyloidosis1.47981142
57MP0004510_myositis1.45775206
58MP0005409_darkened_coat_color1.42776635
59MP0001501_abnormal_sleep_pattern1.41354837
60MP0002736_abnormal_nociception_after1.40695375
61MP0002733_abnormal_thermal_nociception1.39819515
62MP0005310_abnormal_salivary_gland1.38006635
63MP0003121_genomic_imprinting1.37167318
64MP0002184_abnormal_innervation1.36310686
65MP0002163_abnormal_gland_morphology1.34758191
66MP0002067_abnormal_sensory_capabilities1.34667453
67MP0004811_abnormal_neuron_physiology1.34280027
68MP0005451_abnormal_body_composition1.33387985
69MP0000778_abnormal_nervous_system1.32928003
70MP0005174_abnormal_tail_pigmentation1.30476089
71MP0002557_abnormal_social/conspecific_i1.30191837
72MP0005671_abnormal_response_to1.29222749
73MP0001970_abnormal_pain_threshold1.26941084
74MP0002734_abnormal_mechanical_nocicepti1.24171315
75MP0001545_abnormal_hematopoietic_system1.21290669
76MP0005397_hematopoietic_system_phenotyp1.21290669
77MP0000955_abnormal_spinal_cord1.19134930
78MP0002277_abnormal_respiratory_mucosa1.18451197
79MP0010155_abnormal_intestine_physiology1.18393002
80MP0001835_abnormal_antigen_presentation1.17671943
81MP0000858_altered_metastatic_potential1.17041614
82MP0000465_gastrointestinal_hemorrhage1.16268443
83MP0001348_abnormal_lacrimal_gland1.15744261
84MP0000751_myopathy1.15485989
85MP0005666_abnormal_adipose_tissue1.14058439
86MP0001849_ear_inflammation1.13880821
87MP0006082_CNS_inflammation1.13815293
88MP0001851_eye_inflammation1.12451973
89MP0009785_altered_susceptibility_to1.11973410
90MP0006292_abnormal_olfactory_placode1.11449461
91MP0002735_abnormal_chemical_nociception1.10237683
92MP0005379_endocrine/exocrine_gland_phen1.09609814
93MP0004924_abnormal_behavior1.09236634
94MP0005386_behavior/neurological_phenoty1.09236634
95MP0010386_abnormal_urinary_bladder1.08273171
96MP0005387_immune_system_phenotype1.05933508
97MP0001790_abnormal_immune_system1.05933508
98MP0001270_distended_abdomen1.04946877
99MP0002148_abnormal_hypersensitivity_rea1.04473670
100MP0002882_abnormal_neuron_morphology1.03297913
101MP0002933_joint_inflammation1.00760126
102MP0004264_abnormal_extraembryonic_tissu1.00147359
103MP0000920_abnormal_myelination1.00126297
104MP0004885_abnormal_endolymph0.98097558
105MP0001502_abnormal_circadian_rhythm0.97933350
106MP0001984_abnormal_olfaction0.97091955
107MP0005275_abnormal_skin_tensile0.96993219
108MP0005390_skeleton_phenotype0.96949984
109MP0000767_abnormal_smooth_muscle0.96271161
110MP0000015_abnormal_ear_pigmentation0.94800186
111MP0002971_abnormal_brown_adipose0.94226805
112MP0002877_abnormal_melanocyte_morpholog0.93921139
113MP0000685_abnormal_immune_system0.93205781
114MP0005375_adipose_tissue_phenotype0.93130598
115MP0004130_abnormal_muscle_cell0.92825576
116MP0003633_abnormal_nervous_system0.92583183
117MP0003075_altered_response_to0.91923053
118MP0008874_decreased_physiological_sensi0.90936089
119MP0001845_abnormal_inflammatory_respons0.89544306
120MP0000249_abnormal_blood_vessel0.89093727
121MP0005551_abnormal_eye_electrophysiolog0.88794364
122MP0005388_respiratory_system_phenotype0.88675088
123MP0002133_abnormal_respiratory_system0.88675088
124MP0005503_abnormal_tendon_morphology0.88456894
125MP0003879_abnormal_hair_cell0.87522209
126MP0001800_abnormal_humoral_immune0.87319553
127MP0000371_diluted_coat_color0.85976669
128MP0002166_altered_tumor_susceptibility0.85302993
129MP0003045_fibrosis0.85056314
130MP0000703_abnormal_thymus_morphology0.84835824
131MP0002009_preneoplasia0.83274647
132MP0000759_abnormal_skeletal_muscle0.81543168
133MP0009384_cardiac_valve_regurgitation0.81255985
134MP0002429_abnormal_blood_cell0.81060121
135MP0001440_abnormal_grooming_behavior0.80252827
136MP0003866_abnormal_defecation0.80035308
137MP0001819_abnormal_immune_cell0.79567132
138MP0002066_abnormal_motor_capabilities/c0.78882324
139MP0002420_abnormal_adaptive_immunity0.78622246
140MP0003690_abnormal_glial_cell0.78412890
141MP0004142_abnormal_muscle_tone0.77579180
142MP0003453_abnormal_keratinocyte_physiol0.76535791
143MP0004883_abnormal_blood_vessel0.76486082
144MP0002229_neurodegeneration0.75850988
145MP0002722_abnormal_immune_system0.75631973
146MP0002069_abnormal_eating/drinking_beha0.74875952
147MP0006276_abnormal_autonomic_nervous0.74417145
148MP0000689_abnormal_spleen_morphology0.74265944
149MP0001346_abnormal_lacrimal_gland0.73902272
150MP0002452_abnormal_antigen_presenting0.73857901
151MP0002398_abnormal_bone_marrow0.73093378
152MP0004808_abnormal_hematopoietic_stem0.72075894
153MP0002295_abnormal_pulmonary_circulatio0.72012179
154MP0005535_abnormal_body_temperature0.69739527
155MP0003634_abnormal_glial_cell0.69736619
156MP0000733_abnormal_muscle_development0.69365005
157MP0008004_abnormal_stomach_pH0.69358814
158MP0003795_abnormal_bone_structure0.69192148
159MP0002723_abnormal_immune_serum0.69105322
160MP0008789_abnormal_olfactory_epithelium0.67827575
161MP0003631_nervous_system_phenotype0.67052645
162MP0004087_abnormal_muscle_fiber0.67013700
163MP0000716_abnormal_immune_system0.66456325
164MP0001873_stomach_inflammation0.66252336
165MP0002095_abnormal_skin_pigmentation0.66046711
166MP0006138_congestive_heart_failure0.65911840
167MP0005058_abnormal_lysosome_morphology0.65255885
168MP0002152_abnormal_brain_morphology0.65129882
169MP0000747_muscle_weakness0.64655110
170MP0001986_abnormal_taste_sensitivity0.64030948

Predicted human phenotypes

RankGene SetZ-score
1Epileptic encephalopathy (HP:0200134)4.15865183
2Febrile seizures (HP:0002373)4.05804966
3Eczematoid dermatitis (HP:0000976)3.67024459
4Focal seizures (HP:0007359)3.51201785
5Focal motor seizures (HP:0011153)3.46273240
6Supranuclear gaze palsy (HP:0000605)3.30287578
7Abnormality of liposaccharide metabolism (HP:0010968)3.27860833
8Abnormality of glycosphingolipid metabolism (HP:0004343)3.27860833
9Abnormality of glycolipid metabolism (HP:0010969)3.27860833
10Obstructive sleep apnea (HP:0002870)3.17580536
11Volvulus (HP:0002580)3.05775267
12Protrusio acetabuli (HP:0003179)3.00935147
13Macroorchidism (HP:0000053)2.95968384
14Dysostosis multiplex (HP:0000943)2.84776614
15Visual hallucinations (HP:0002367)2.82590841
16Increased variability in muscle fiber diameter (HP:0003557)2.65527362
17Mucopolysacchariduria (HP:0008155)2.64700666
18Urinary glycosaminoglycan excretion (HP:0003541)2.64700666
19Spontaneous hematomas (HP:0007420)2.63709673
20Abnormality of the lower motor neuron (HP:0002366)2.58543860
21Open mouth (HP:0000194)2.58453383
22Papilledema (HP:0001085)2.58218568
23Failure to thrive in infancy (HP:0001531)2.58032852
24Asymmetric septal hypertrophy (HP:0001670)2.57607450
25Astrocytoma (HP:0009592)2.57027728
26Abnormality of the astrocytes (HP:0100707)2.57027728
27Dialeptic seizures (HP:0011146)2.56747834
28Progressive cerebellar ataxia (HP:0002073)2.56529858
29Myositis (HP:0100614)2.55506470
30Abnormality of macrophages (HP:0004311)2.52452462
31Postural instability (HP:0002172)2.50573418
32Recurrent bacterial skin infections (HP:0005406)2.48699015
33Cellulitis (HP:0100658)2.44399870
34Hand muscle atrophy (HP:0009130)2.43838896
35Abnormal delayed hypersensitivity skin test (HP:0002963)2.42369878
36Neoplasm of the heart (HP:0100544)2.42177493
37Recurrent abscess formation (HP:0002722)2.42122882
38Abnormality of skeletal muscle fiber size (HP:0012084)2.39128668
39Thin bony cortex (HP:0002753)2.37064810
40Cervical subluxation (HP:0003308)2.35816093
41Atonic seizures (HP:0010819)2.35506864
42Increased IgE level (HP:0003212)2.34722282
43Neurofibrillary tangles (HP:0002185)2.34112978
44Generalized tonic-clonic seizures (HP:0002069)2.33781226
45Mutism (HP:0002300)2.32862335
46Depression (HP:0000716)2.32653908
47Drooling (HP:0002307)2.31833427
48Excessive salivation (HP:0003781)2.31833427
49Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.31598188
50Aortic aneurysm (HP:0004942)2.30384772
51Truncal ataxia (HP:0002078)2.29466852
52Impaired smooth pursuit (HP:0007772)2.27850213
53Neuronal loss in central nervous system (HP:0002529)2.26593832
54Orchitis (HP:0100796)2.24102810
55Genetic anticipation (HP:0003743)2.22618599
56Cerebral aneurysm (HP:0004944)2.22560250
57Abnormality of ocular smooth pursuit (HP:0000617)2.22551552
58Mediastinal lymphadenopathy (HP:0100721)2.21003708
59Hemiplegia (HP:0002301)2.20798384
60Gingivitis (HP:0000230)2.20700357
61Absence seizures (HP:0002121)2.20643028
62Abnormal hair whorl (HP:0010721)2.19321544
63Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.17708834
64Peritonitis (HP:0002586)2.16522263
65Absent speech (HP:0001344)2.16033216
66Inappropriate behavior (HP:0000719)2.10760553
67Vascular tortuosity (HP:0004948)2.10427565
68Absent frontal sinuses (HP:0002688)2.09493614
69Apathy (HP:0000741)2.09226534
70Increased connective tissue (HP:0009025)2.07105030
71Emphysema (HP:0002097)2.05822947
72Hyperventilation (HP:0002883)2.05180345
73Ependymoma (HP:0002888)2.04372001
74Generalized hypotonia (HP:0001290)2.04284507
75Interstitial pulmonary disease (HP:0006530)2.04103139
76Protruding tongue (HP:0010808)2.04084794
77Difficulty running (HP:0009046)2.03854704
78Hip dysplasia (HP:0001385)2.03639508
79Myokymia (HP:0002411)2.03408475
80Upper limb amyotrophy (HP:0009129)2.02125986
81Distal upper limb amyotrophy (HP:0007149)2.02125986
82Aneurysm (HP:0002617)2.01746495
83Prolonged bleeding time (HP:0003010)2.01264577
84Arterial tortuosity (HP:0005116)2.00945596
85Dilatation of the ascending aorta (HP:0005111)2.00087809
86Action tremor (HP:0002345)1.98920266
87Urinary bladder sphincter dysfunction (HP:0002839)1.98829711
88Tapered finger (HP:0001182)1.98429400
89Hemiparesis (HP:0001269)1.98118834
90Loss of speech (HP:0002371)1.97052306
91Cerebral inclusion bodies (HP:0100314)1.95970229
92Spinal canal stenosis (HP:0003416)1.95872252
93Recurrent gram-negative bacterial infections (HP:0005420)1.95808471
94Gaze-evoked nystagmus (HP:0000640)1.95625354
95Gastrointestinal stroma tumor (HP:0100723)1.95365842
96Elevated erythrocyte sedimentation rate (HP:0003565)1.93234234
97Recurrent fungal infections (HP:0002841)1.91812639
98Centrally nucleated skeletal muscle fibers (HP:0003687)1.91437383
99Diminished motivation (HP:0000745)1.89633851
100Chronic mucocutaneous candidiasis (HP:0002728)1.89067044
101Recurrent cutaneous fungal infections (HP:0011370)1.89067044
102Mitral regurgitation (HP:0001653)1.87799478
103Panhypogammaglobulinemia (HP:0003139)1.87669438
104Increased cerebral lipofuscin (HP:0011813)1.86884713
105Amblyopia (HP:0000646)1.86700402
106Tented upper lip vermilion (HP:0010804)1.85892764
107Diplopia (HP:0000651)1.85138360
108Abnormality of binocular vision (HP:0011514)1.85138360
109Iris hypopigmentation (HP:0007730)1.84973992
110Resting tremor (HP:0002322)1.83232907
111Abnormality of the corticospinal tract (HP:0002492)1.82676626
112Systemic lupus erythematosus (HP:0002725)1.82383383
113Exotropia (HP:0000577)1.82035312
114Hypercortisolism (HP:0001578)1.81753133
115Exercise-induced myalgia (HP:0003738)1.80744490
116Abnormal eating behavior (HP:0100738)1.79994029
117Optic neuritis (HP:0100653)1.79964804
118Retrobulbar optic neuritis (HP:0100654)1.79964804
119Bilateral microphthalmos (HP:0007633)1.79853227
120Joint stiffness (HP:0001387)1.79404207
121Ocular albinism (HP:0001107)1.78792481
122Broad-based gait (HP:0002136)1.78532508
123Gingival bleeding (HP:0000225)1.78479494
124Poor eye contact (HP:0000817)1.78236468
125Meningitis (HP:0001287)1.78235675
126Gastrointestinal inflammation (HP:0004386)1.78202823
127Abnormality of the fingertips (HP:0001211)1.78189566
128Aortic dissection (HP:0002647)1.78029968
129Spondylolisthesis (HP:0003302)1.77031790
130Abnormal social behavior (HP:0012433)1.76971167
131Impaired social interactions (HP:0000735)1.76971167
132Recurrent skin infections (HP:0001581)1.75995340
133Polyphagia (HP:0002591)1.75965907
134Epistaxis (HP:0000421)1.75652227
135Bradykinesia (HP:0002067)1.75323192
136Amyloidosis (HP:0011034)1.75275669
137Gastrointestinal infarctions (HP:0005244)1.75163184
138Glioma (HP:0009733)1.75061218
139Pointed chin (HP:0000307)1.74384473
140Ankle clonus (HP:0011448)1.73832435
141Vasculitis (HP:0002633)1.73795961
142Hyperacusis (HP:0010780)1.73493397
143Abnormality of the peritoneum (HP:0002585)1.72532922
144Abnormality of mucopolysaccharide metabolism (HP:0011020)1.71876554
145Abnormality of polysaccharide metabolism (HP:0011012)1.71876554
146Abnormality of glycosaminoglycan metabolism (HP:0004371)1.71876554
147Purpura (HP:0000979)1.71840699
148Distal lower limb amyotrophy (HP:0008944)1.71751043
149Vertebral compression fractures (HP:0002953)1.71701796
150Impaired vibration sensation in the lower limbs (HP:0002166)1.70786717
151Hepatoblastoma (HP:0002884)1.70590923
152Lower limb muscle weakness (HP:0007340)1.70200955
153Chest pain (HP:0100749)1.69257556
154Spastic gait (HP:0002064)1.69044537
155Colitis (HP:0002583)1.68883434
156Slow saccadic eye movements (HP:0000514)1.68701665
157Hyporeflexia of lower limbs (HP:0002600)1.68678541
158Type 1 muscle fiber predominance (HP:0003803)1.68486987
159Aqueductal stenosis (HP:0002410)1.68169312
160Syringomyelia (HP:0003396)1.67465266
161Spinal cord lesions (HP:0100561)1.67465266
162Broad metatarsal (HP:0001783)1.67008692
163Polycythemia (HP:0001901)1.66977863
164Obstructive lung disease (HP:0006536)1.66930264
165Chronic obstructive pulmonary disease (HP:0006510)1.66930264
166Intention tremor (HP:0002080)1.66902613
167Peripheral hypomyelination (HP:0007182)1.66759928
168Restrictive lung disease (HP:0002091)1.66601447
169Inflammation of the large intestine (HP:0002037)1.66221223
170Abnormality of the periventricular white matter (HP:0002518)1.65831718
171Abnormality of chromosome segregation (HP:0002916)1.65123074
172Epileptiform EEG discharges (HP:0011182)1.64741073
173EEG with generalized epileptiform discharges (HP:0011198)1.64553733
174Premature loss of primary teeth (HP:0006323)1.63534273
175Premature rupture of membranes (HP:0001788)1.63082936
176Hypoplasia of the iris (HP:0007676)1.63055469
177Akinesia (HP:0002304)1.63014566
178Lower limb amyotrophy (HP:0007210)1.61883646
179Congenital stationary night blindness (HP:0007642)1.60456012
180Supernumerary nipples (HP:0002558)1.60147253

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK32.96348240
2MAP3K132.76318942
3MAP3K92.70930122
4CDK122.60372790
5INSRR2.57210289
6NTRK22.39965252
7TRIB32.33820536
8MAP3K42.14053078
9MARK12.09546538
10RIPK11.97853029
11SIK11.93385448
12MAP4K11.93238816
13MAP2K71.86046016
14CAMK1G1.80978350
15SIK21.77559407
16MAP2K41.77445809
17PRPF4B1.76424974
18CDC42BPA1.74982105
19CSF1R1.74632101
20CAMK1D1.73981625
21GRK51.72612978
22MAP2K31.65493432
23EPHA41.61042155
24CAMKK21.57816735
25BLK1.54507639
26RIPK41.53701378
27BRD41.52973856
28FGFR41.50567155
29CAMKK11.42801794
30CCNB11.42668257
31ZAP701.41970382
32MARK21.38839626
33HIPK21.34678730
34MAP3K71.34155187
35NTRK11.33110756
36FES1.32346374
37JAK11.31586905
38FGFR31.27728828
39PDGFRA1.27159407
40SIK31.23230629
41ERN11.22809059
42KIT1.22497774
43DAPK21.22065708
44TTN1.21744509
45GRK61.20250523
46CSK1.20082357
47PRKD21.19257990
48TNIK1.19052605
49KSR11.15685385
50CASK1.15173973
51PAK61.13631840
52MINK11.12805360
53MATK1.09669608
54TYRO31.08883727
55CAMK41.07923400
56MAPK71.06607345
57IRAK41.03058894
58MAP3K61.03034696
59RET1.02688106
60ICK1.02445484
61JAK31.01223483
62SYK0.99809263
63CDK50.99116336
64DYRK1B0.96403500
65CAMK10.94630569
66GRK10.90542278
67WNK10.90261212
68KSR20.90248187
69MAP3K30.90089322
70NEK90.89420229
71ADRBK20.89173460
72MAP3K10.86425459
73DDR20.85144383
74PRKD30.81680139
75TYK20.81161241
76MAPK130.79157947
77SMG10.78981412
78IKBKE0.74667663
79PDPK10.74204832
80MAP3K100.74001692
81MAP3K110.73635801
82TGFBR20.73468904
83EEF2K0.72903008
84HCK0.72895194
85FGR0.72649453
86TAOK10.72302826
87PIK3CG0.72155502
88DAPK10.71894961
89SGK20.71869563
90JAK20.71045849
91PDGFRB0.70929656
92PHKG10.70214843
93PHKG20.70214843
94MOS0.68724757
95SGK30.68451135
96PRKCH0.68433974
97DMPK0.65905425
98PTK60.65808598
99STK110.65439693
100STK380.64717062
101TAOK30.63543782
102MAPK120.62980762
103MAP3K140.62336951
104MTOR0.61284431
105CHUK0.61178347
106ITK0.60301831
107TNK20.59068751
108PDK10.58747557
109GRK70.58384367
110MAPK100.57940216
111BTK0.57653033
112EPHB10.57435416
113IKBKB0.57114565
114CDK190.56965948
115SGK10.56116952
116PLK20.55840733
117TAOK20.54671332
118PRKAA10.53691566
119BMPR20.53659946
120PRKCG0.53358008
121RPS6KA20.53253073
122LYN0.53033453
123MAP2K20.52897681
124RPS6KL10.51885764
125RPS6KC10.51885764
126TESK10.51698519
127CDK60.50003817
128MARK30.49520448
129EPHA30.49394670
130LRRK20.48806331
131PRKAA20.47790468
132UHMK10.47500934
133ALK0.47485359
134PRKD10.47241239
135SGK4940.47155830
136SGK2230.47155830
137PKN10.45775283
138NEK60.45614389
139CLK10.44683810
140DYRK1A0.44642658
141ADRBK10.40097296
142MAPK80.39176552
143TBK10.37458036
144RPS6KA30.36584827
145FYN0.36370986
146LCK0.36354336

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047212.07785661
2Other glycan degradation_Homo sapiens_hsa005112.07119835
3Nicotine addiction_Homo sapiens_hsa050332.01995537
4Morphine addiction_Homo sapiens_hsa050321.93059297
5Circadian entrainment_Homo sapiens_hsa047131.86760894
6Olfactory transduction_Homo sapiens_hsa047401.85663047
7GABAergic synapse_Homo sapiens_hsa047271.81017875
8Glutamatergic synapse_Homo sapiens_hsa047241.77243128
9Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.75912694
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.72950557
11Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.66329642
12Phosphatidylinositol signaling system_Homo sapiens_hsa040701.63556451
13Leishmaniasis_Homo sapiens_hsa051401.61379911
14Type II diabetes mellitus_Homo sapiens_hsa049301.54861122
15Insulin secretion_Homo sapiens_hsa049111.50821945
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.48602718
17Long-term potentiation_Homo sapiens_hsa047201.48422519
18Cholinergic synapse_Homo sapiens_hsa047251.42214311
19Salivary secretion_Homo sapiens_hsa049701.36219465
20Dopaminergic synapse_Homo sapiens_hsa047281.35309876
21Oxytocin signaling pathway_Homo sapiens_hsa049211.34043915
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.33370049
23Notch signaling pathway_Homo sapiens_hsa043301.33180615
24Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.32363220
25Staphylococcus aureus infection_Homo sapiens_hsa051501.32107645
26Renin secretion_Homo sapiens_hsa049241.29567114
27Inositol phosphate metabolism_Homo sapiens_hsa005621.27626973
28Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.26428762
29Taste transduction_Homo sapiens_hsa047421.26262995
30Neurotrophin signaling pathway_Homo sapiens_hsa047221.26116221
31AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.24951344
32Serotonergic synapse_Homo sapiens_hsa047261.23794931
33GnRH signaling pathway_Homo sapiens_hsa049121.20725285
34Long-term depression_Homo sapiens_hsa047301.19347837
35Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.18909671
36Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.17770138
37Leukocyte transendothelial migration_Homo sapiens_hsa046701.17405713
38Cocaine addiction_Homo sapiens_hsa050301.14689337
39B cell receptor signaling pathway_Homo sapiens_hsa046621.14108564
40ErbB signaling pathway_Homo sapiens_hsa040121.13545922
41Amphetamine addiction_Homo sapiens_hsa050311.11265911
42Glioma_Homo sapiens_hsa052141.10743875
43Phospholipase D signaling pathway_Homo sapiens_hsa040721.10538847
44Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.06653107
45Gastric acid secretion_Homo sapiens_hsa049711.05663396
46Non-small cell lung cancer_Homo sapiens_hsa052231.05336157
47mTOR signaling pathway_Homo sapiens_hsa041501.05303885
48Chemokine signaling pathway_Homo sapiens_hsa040621.04090155
49Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.04008103
50Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.03683839
51Calcium signaling pathway_Homo sapiens_hsa040201.02847604
52Estrogen signaling pathway_Homo sapiens_hsa049151.02313420
53Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.01654269
54cAMP signaling pathway_Homo sapiens_hsa040241.01557916
55Viral myocarditis_Homo sapiens_hsa054161.00462665
56Thyroid hormone signaling pathway_Homo sapiens_hsa049190.98768508
57Osteoclast differentiation_Homo sapiens_hsa043800.98500252
58Carbohydrate digestion and absorption_Homo sapiens_hsa049730.98389124
59Hepatitis B_Homo sapiens_hsa051610.98252103
60Amoebiasis_Homo sapiens_hsa051460.98053512
61Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.96639536
62Prolactin signaling pathway_Homo sapiens_hsa049170.95157351
63Hepatitis C_Homo sapiens_hsa051600.93844577
64Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.93221281
65NF-kappa B signaling pathway_Homo sapiens_hsa040640.90963314
66Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.89980741
67Glycosaminoglycan degradation_Homo sapiens_hsa005310.89804125
68Dorso-ventral axis formation_Homo sapiens_hsa043200.89591721
69T cell receptor signaling pathway_Homo sapiens_hsa046600.89347567
70Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.88935771
71Focal adhesion_Homo sapiens_hsa045100.88729192
72MAPK signaling pathway_Homo sapiens_hsa040100.88271940
73Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.88107380
74Endometrial cancer_Homo sapiens_hsa052130.87804699
75Allograft rejection_Homo sapiens_hsa053300.87612897
76Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.87406150
77Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.86524630
78Gap junction_Homo sapiens_hsa045400.86252117
79Chronic myeloid leukemia_Homo sapiens_hsa052200.85945581
80Malaria_Homo sapiens_hsa051440.84970520
81Phagosome_Homo sapiens_hsa041450.84870811
82Platelet activation_Homo sapiens_hsa046110.82612543
83Autoimmune thyroid disease_Homo sapiens_hsa053200.81942811
84Choline metabolism in cancer_Homo sapiens_hsa052310.81859332
85Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.81724494
86cGMP-PKG signaling pathway_Homo sapiens_hsa040220.81407056
87Acute myeloid leukemia_Homo sapiens_hsa052210.80736623
88Graft-versus-host disease_Homo sapiens_hsa053320.78057643
89Axon guidance_Homo sapiens_hsa043600.76461291
90Sphingolipid signaling pathway_Homo sapiens_hsa040710.74896860
91VEGF signaling pathway_Homo sapiens_hsa043700.73810990
92Colorectal cancer_Homo sapiens_hsa052100.73458769
93Shigellosis_Homo sapiens_hsa051310.73434382
94Pertussis_Homo sapiens_hsa051330.73428032
95Toll-like receptor signaling pathway_Homo sapiens_hsa046200.71457592
96Collecting duct acid secretion_Homo sapiens_hsa049660.70731218
97Pancreatic cancer_Homo sapiens_hsa052120.70180303
98Lysosome_Homo sapiens_hsa041420.69688590
99Ovarian steroidogenesis_Homo sapiens_hsa049130.68872031
100Hematopoietic cell lineage_Homo sapiens_hsa046400.68856899
101Prostate cancer_Homo sapiens_hsa052150.68678636
102Regulation of actin cytoskeleton_Homo sapiens_hsa048100.68440227
103Insulin signaling pathway_Homo sapiens_hsa049100.67996331
104Type I diabetes mellitus_Homo sapiens_hsa049400.67540189
105Rap1 signaling pathway_Homo sapiens_hsa040150.67514925
106FoxO signaling pathway_Homo sapiens_hsa040680.67065078
107Endocytosis_Homo sapiens_hsa041440.66826773
108Salmonella infection_Homo sapiens_hsa051320.66465818
109Ras signaling pathway_Homo sapiens_hsa040140.66203350
110Tuberculosis_Homo sapiens_hsa051520.65512582
111Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.64350141
112Toxoplasmosis_Homo sapiens_hsa051450.63781743
113Adipocytokine signaling pathway_Homo sapiens_hsa049200.63536039
114Longevity regulating pathway - mammal_Homo sapiens_hsa042110.63473872
115Apoptosis_Homo sapiens_hsa042100.62535502
116Dilated cardiomyopathy_Homo sapiens_hsa054140.62314141
117Prion diseases_Homo sapiens_hsa050200.61927511
118Vascular smooth muscle contraction_Homo sapiens_hsa042700.61177871
119Melanogenesis_Homo sapiens_hsa049160.59315221
120Phototransduction_Homo sapiens_hsa047440.59238409
121Intestinal immune network for IgA production_Homo sapiens_hsa046720.58347807
122Primary immunodeficiency_Homo sapiens_hsa053400.57840279
123TNF signaling pathway_Homo sapiens_hsa046680.57423067
124SNARE interactions in vesicular transport_Homo sapiens_hsa041300.54760074
125RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.53178167
126Jak-STAT signaling pathway_Homo sapiens_hsa046300.52891173
127Measles_Homo sapiens_hsa051620.52094967
128Insulin resistance_Homo sapiens_hsa049310.51412295
129Influenza A_Homo sapiens_hsa051640.51320471
130Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51066406
131Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50342158
132Renal cell carcinoma_Homo sapiens_hsa052110.50152627

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