VPS4A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 and mouse Skd1 proteins. The mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be really an yeast Vps4 ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 16; the gene for the other resides on chromosome 18. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.28611157
2synaptic vesicle exocytosis (GO:0016079)5.27905511
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.20367989
4regulation of short-term neuronal synaptic plasticity (GO:0048172)5.18863475
5vocalization behavior (GO:0071625)4.59760405
6locomotory exploration behavior (GO:0035641)4.44183848
7glutamate secretion (GO:0014047)4.43599771
8regulation of mammary gland epithelial cell proliferation (GO:0033599)4.41913371
9regulation of synaptic vesicle exocytosis (GO:2000300)4.39931964
10response to pheromone (GO:0019236)4.29821784
11regulation of synapse structural plasticity (GO:0051823)4.28725930
12protein localization to synapse (GO:0035418)4.27019756
13positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.22108244
14synaptic vesicle docking involved in exocytosis (GO:0016081)4.18446865
15regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.13329909
16protein retention in ER lumen (GO:0006621)4.13222399
17regulation of synaptic vesicle transport (GO:1902803)4.12672458
18proline biosynthetic process (GO:0006561)4.06674100
19positive regulation of synapse maturation (GO:0090129)4.04493733
20layer formation in cerebral cortex (GO:0021819)4.04096387
21negative regulation of erythrocyte differentiation (GO:0045647)3.98196758
22neuronal action potential propagation (GO:0019227)3.95881532
23cellular potassium ion homeostasis (GO:0030007)3.95792992
24negative regulation of cell size (GO:0045792)3.94272957
25regulation of glutamate receptor signaling pathway (GO:1900449)3.90964307
26sodium ion export (GO:0071436)3.85788201
27activation of protein kinase A activity (GO:0034199)3.83390889
28exploration behavior (GO:0035640)3.82076373
29negative regulation of microtubule polymerization (GO:0031115)3.73542980
30neuron cell-cell adhesion (GO:0007158)3.71319041
31maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.71203590
32neurotransmitter secretion (GO:0007269)3.68055468
33ionotropic glutamate receptor signaling pathway (GO:0035235)3.66438913
34positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.65679524
35retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.55477730
36creatine metabolic process (GO:0006600)3.51458524
37regulation of neuronal synaptic plasticity (GO:0048168)3.50551613
38negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.48745620
39apoptotic process involved in morphogenesis (GO:0060561)3.44165629
40regulation of translational fidelity (GO:0006450)3.42060537
41regulation of NFAT protein import into nucleus (GO:0051532)3.41376663
42positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling3.40934330
43Golgi transport vesicle coating (GO:0048200)3.40821701
44COPI coating of Golgi vesicle (GO:0048205)3.40821701
45membrane depolarization during action potential (GO:0086010)3.40238579
46cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.39862462
47adherens junction assembly (GO:0034333)3.39447315
48glutamate receptor signaling pathway (GO:0007215)3.39107739
49cell communication by electrical coupling (GO:0010644)3.38481216
50spliceosomal tri-snRNP complex assembly (GO:0000244)3.37081554
51regulation of early endosome to late endosome transport (GO:2000641)3.36909166
52membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.35535431
53synaptic transmission, glutamatergic (GO:0035249)3.34851541
54regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.34848031
55peptidyl-arginine omega-N-methylation (GO:0035247)3.33139813
56cell-substrate adherens junction assembly (GO:0007045)3.32691042
57focal adhesion assembly (GO:0048041)3.32691042
58protein insertion into membrane (GO:0051205)3.32414970
59regulation of long-term neuronal synaptic plasticity (GO:0048169)3.30037857
60neuron-neuron synaptic transmission (GO:0007270)3.30037758
61protein localization to endosome (GO:0036010)3.25187658
62positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.24732132
63long-term memory (GO:0007616)3.21764141
64mannose metabolic process (GO:0006013)3.21236832
65neuron recognition (GO:0008038)3.20671783
66nucleosome disassembly (GO:0006337)3.18656235
67protein-DNA complex disassembly (GO:0032986)3.18656235
68calcium ion-dependent exocytosis (GO:0017156)3.16707895
69intracellular estrogen receptor signaling pathway (GO:0030520)3.16004655
703-UTR-mediated mRNA stabilization (GO:0070935)3.15007864
71synaptic vesicle endocytosis (GO:0048488)3.12374005
72positive regulation of synaptic transmission, GABAergic (GO:0032230)3.11942763
73glucose 6-phosphate metabolic process (GO:0051156)3.11216176
74regulation of chromatin binding (GO:0035561)3.10940991
75gamma-aminobutyric acid signaling pathway (GO:0007214)3.09538517
76vesicle transport along microtubule (GO:0047496)3.09170712
77NADH metabolic process (GO:0006734)3.05321380
78dendritic spine morphogenesis (GO:0060997)3.04259277
79GDP-mannose metabolic process (GO:0019673)3.02990886
80organelle transport along microtubule (GO:0072384)3.01601212
81positive regulation of membrane potential (GO:0045838)3.00823909
82positive regulation of potassium ion transmembrane transport (GO:1901381)2.98265411
83barbed-end actin filament capping (GO:0051016)2.97180218
84positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.96827482
85cell migration in hindbrain (GO:0021535)2.96816503
86regulation of synaptic transmission, glutamatergic (GO:0051966)2.96269682
87neuromuscular process controlling posture (GO:0050884)2.95574577
88neurotransmitter transport (GO:0006836)2.94861525
89dendrite morphogenesis (GO:0048813)2.94454767
90mating behavior (GO:0007617)2.93258092
91positive regulation of protein dephosphorylation (GO:0035307)2.93110821
92regulation of dendritic spine morphogenesis (GO:0061001)2.92282791
93modulation by virus of host process (GO:0019054)2.92114752
94regulation of vesicle fusion (GO:0031338)2.91672749
95regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.91021074
96gamma-aminobutyric acid transport (GO:0015812)2.88089786
97regulation of excitatory postsynaptic membrane potential (GO:0060079)2.87762487
98regulation of neurotransmitter secretion (GO:0046928)2.87390867
99neurotransmitter-gated ion channel clustering (GO:0072578)2.87261600
100regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.87204708
101axonal fasciculation (GO:0007413)2.86841735
102synaptic vesicle transport (GO:0048489)2.86579740
103establishment of synaptic vesicle localization (GO:0097480)2.86579740
104modulation by symbiont of host cellular process (GO:0044068)2.85895802
105regulation of synaptic plasticity (GO:0048167)2.85747737
106cerebellar granule cell differentiation (GO:0021707)2.83143388
107cytoskeletal anchoring at plasma membrane (GO:0007016)2.83009883
108regulation of synapse maturation (GO:0090128)2.83004524
109potassium ion import (GO:0010107)2.81583293
110proline transport (GO:0015824)2.81417441
111axon cargo transport (GO:0008088)2.80838128
112proline metabolic process (GO:0006560)2.80601374
113behavioral defense response (GO:0002209)2.80155168
114behavioral fear response (GO:0001662)2.80155168
115mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.79926461
116modulation by virus of host morphology or physiology (GO:0019048)2.78149598
117prepulse inhibition (GO:0060134)2.76660853
118regulation of postsynaptic membrane potential (GO:0060078)2.76213288
119positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.75791134
120regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.75791134
121mRNA stabilization (GO:0048255)2.75577448
122RNA stabilization (GO:0043489)2.75577448
123presynaptic membrane organization (GO:0097090)2.75542603
124maternal placenta development (GO:0001893)2.74836176
125regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.74724904
126DNA unwinding involved in DNA replication (GO:0006268)2.74220739
127establishment of vesicle localization (GO:0051650)2.73806523
128response to auditory stimulus (GO:0010996)2.73662015
129regulation of neurotransmitter levels (GO:0001505)2.73286417
130cerebellar Purkinje cell layer development (GO:0021680)2.73178971
131regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.71974618
132long-term synaptic potentiation (GO:0060291)2.71683856
133regulation of neurotransmitter transport (GO:0051588)2.71418769
134membrane depolarization (GO:0051899)2.70513604
135dosage compensation (GO:0007549)2.70415799
136gluconeogenesis (GO:0006094)2.70338420
137negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.70098522
138histone arginine methylation (GO:0034969)2.69490955
139neuromuscular process controlling balance (GO:0050885)2.69391617
140negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.69147826
141mitochondrion transport along microtubule (GO:0047497)2.67227463
142establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.67227463
143potassium ion homeostasis (GO:0055075)2.66973861
144cerebellar Purkinje cell differentiation (GO:0021702)2.66927621
145mitotic chromosome condensation (GO:0007076)2.66873128
146positive regulation of potassium ion transport (GO:0043268)2.66763352
147membrane repolarization (GO:0086009)2.66720325
148fear response (GO:0042596)2.66100369
149regulation of ARF protein signal transduction (GO:0032012)2.65671908
150regulation of voltage-gated calcium channel activity (GO:1901385)2.65219663
151activation of Rac GTPase activity (GO:0032863)2.65052389
152dopamine receptor signaling pathway (GO:0007212)2.65022157
153establishment of mitochondrion localization (GO:0051654)2.64994701
154glucocorticoid receptor signaling pathway (GO:0042921)2.64661151
155cell-cell junction maintenance (GO:0045217)2.64363930
156positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.63772250
157transmission of nerve impulse (GO:0019226)2.63732142
158membrane hyperpolarization (GO:0060081)2.63377448
159regulation of glucose import in response to insulin stimulus (GO:2001273)2.60900525
160monosaccharide biosynthetic process (GO:0046364)2.59139475
161peptidyl-arginine N-methylation (GO:0035246)2.58984744
162peptidyl-arginine methylation (GO:0018216)2.58984744
163activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.58212425
164ribosomal small subunit biogenesis (GO:0042274)2.57348278
165positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.56504227
166activation of MAPKKK activity (GO:0000185)2.55739156
167hexose biosynthetic process (GO:0019319)2.55350627
168protein targeting to plasma membrane (GO:0072661)2.54591345
169planar cell polarity pathway involved in neural tube closure (GO:0090179)2.51637098
170positive regulation of nuclease activity (GO:0032075)2.49509382
171adenine nucleotide transport (GO:0051503)2.47930029
172UV protection (GO:0009650)2.47861088
173pentose-phosphate shunt (GO:0006098)2.47456576
174regulation of protein dephosphorylation (GO:0035304)2.45703033
175regulation of ARF GTPase activity (GO:0032312)2.45198017
176negative regulation of necrotic cell death (GO:0060547)2.42508476
177regulation of cholesterol homeostasis (GO:2000188)2.41301214
178peptidyl-proline hydroxylation (GO:0019511)2.40409187
179semaphorin-plexin signaling pathway (GO:0071526)2.40194600
180oxaloacetate metabolic process (GO:0006107)2.40186807
181RNA localization (GO:0006403)2.36096179
182vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.35653999
183protein complex localization (GO:0031503)2.35569049

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.40942172
2REST_21632747_ChIP-Seq_MESCs_Mouse2.98700009
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.82639608
4VDR_21846776_ChIP-Seq_THP-1_Human2.79539412
5MYC_22102868_ChIP-Seq_BL_Human2.77209512
6RARB_27405468_Chip-Seq_BRAIN_Mouse2.68040890
7GBX2_23144817_ChIP-Seq_PC3_Human2.65306447
8REST_18959480_ChIP-ChIP_MESCs_Mouse2.61396826
9IKZF1_21737484_ChIP-ChIP_HCT116_Human2.57421817
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.55192028
11THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.53513994
12* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.52481509
13JARID2_20064375_ChIP-Seq_MESCs_Mouse2.50664902
14TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.45471423
15DROSHA_22980978_ChIP-Seq_HELA_Human2.44720037
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.42239312
17JARID2_20075857_ChIP-Seq_MESCs_Mouse2.37581538
18EZH2_27294783_Chip-Seq_ESCs_Mouse2.32784297
19KDM2B_26808549_Chip-Seq_SUP-B15_Human2.32307463
20RNF2_18974828_ChIP-Seq_MESCs_Mouse2.31721953
21EZH2_18974828_ChIP-Seq_MESCs_Mouse2.31721953
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.29753484
23KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.26757716
24MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.26379389
25CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.25213010
26NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.21632427
27ELK3_25401928_ChIP-Seq_HUVEC_Human2.20647978
28SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.19996552
29EZH2_27304074_Chip-Seq_ESCs_Mouse2.14919222
30EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.14654911
31RACK7_27058665_Chip-Seq_MCF-7_Human2.10437389
32SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.10426774
33ZNF274_21170338_ChIP-Seq_K562_Hela2.08650080
34SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.07687957
35RARG_19884340_ChIP-ChIP_MEFs_Mouse2.06750488
36KDM2B_26808549_Chip-Seq_DND41_Human2.06030542
37HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.04680509
38PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.04304604
39DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.88784244
40NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.87246363
41RNF2_27304074_Chip-Seq_ESCs_Mouse1.87194386
42TET1_21451524_ChIP-Seq_MESCs_Mouse1.86624400
43TCF7_22412390_ChIP-Seq_EML_Mouse1.86553075
44P68_20966046_ChIP-Seq_HELA_Human1.81890968
45EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.80400004
46EED_16625203_ChIP-ChIP_MESCs_Mouse1.80302572
47ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.78150090
48ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.77262139
49CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.73509611
50CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.70714221
51CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.64721070
52CTBP2_25329375_ChIP-Seq_LNCAP_Human1.62526765
53TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.60947401
54SA1_27219007_Chip-Seq_ERYTHROID_Human1.57230363
55XRN2_22483619_ChIP-Seq_HELA_Human1.57034200
56CTCF_27219007_Chip-Seq_ERYTHROID_Human1.56727288
57E2F7_22180533_ChIP-Seq_HELA_Human1.55013814
58NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.51919098
59KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.50978544
60NR3C1_23031785_ChIP-Seq_PC12_Mouse1.50591971
61CREB1_26743006_Chip-Seq_LNCaP_Human1.48921997
62DNAJC2_21179169_ChIP-ChIP_NT2_Human1.46305831
63ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.45649730
64CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.45631503
65CTBP1_25329375_ChIP-Seq_LNCAP_Human1.45621827
66UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.45596088
67KDM2B_26808549_Chip-Seq_JURKAT_Human1.43786710
68RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.42308246
69STAT6_21828071_ChIP-Seq_BEAS2B_Human1.40538611
70THAP11_20581084_ChIP-Seq_MESCs_Mouse1.38749517
71TP63_17297297_ChIP-ChIP_HaCaT_Human1.37668197
72* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.36786096
73ERG_21242973_ChIP-ChIP_JURKAT_Human1.35207333
74EGR1_19374776_ChIP-ChIP_THP-1_Human1.33274037
75MAF_26560356_Chip-Seq_TH2_Human1.33028810
76AR_21572438_ChIP-Seq_LNCaP_Human1.32779195
77SMAD4_21799915_ChIP-Seq_A2780_Human1.31913289
78* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.31297199
79CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.31092626
80KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.30976498
81MYC_18555785_ChIP-Seq_MESCs_Mouse1.30815531
82ESR2_21235772_ChIP-Seq_MCF-7_Human1.28742434
83TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25241660
84FOXM1_23109430_ChIP-Seq_U2OS_Human1.25018434
85SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.24976722
86P300_27058665_Chip-Seq_ZR-75-30cells_Human1.24820060
87CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.24642855
88MYC_18358816_ChIP-ChIP_MESCs_Mouse1.23722496
89ELF1_20517297_ChIP-Seq_JURKAT_Human1.23535828
90MAF_26560356_Chip-Seq_TH1_Human1.22673617
91* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.21950964
92RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.21913290
93RING1B_27294783_Chip-Seq_ESCs_Mouse1.20789546
94TAF15_26573619_Chip-Seq_HEK293_Human1.20318380
95NCOR1_26117541_ChIP-Seq_K562_Human1.18149979
96TP53_22127205_ChIP-Seq_IMR90_Human1.16978588
97CIITA_25753668_ChIP-Seq_RAJI_Human1.16164549
98TET1_21490601_ChIP-Seq_MESCs_Mouse1.16026381
99MYC_19079543_ChIP-ChIP_MESCs_Mouse1.15862190
100GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.15716118
101ZFP281_18757296_ChIP-ChIP_E14_Mouse1.15481794
102* SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.15198225
103ZFP281_27345836_Chip-Seq_ESCs_Mouse1.15028795
104BCOR_27268052_Chip-Seq_Bcells_Human1.14970556
105NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.14751094
106CLOCK_20551151_ChIP-Seq_293T_Human1.13764454
107SOX2_21211035_ChIP-Seq_LN229_Gbm1.13467828
108VDR_24763502_ChIP-Seq_THP-1_Human1.13186638
109SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.12910708
110TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.11971447
111SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.09197029
112KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.08611545
113SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.07500388
114KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.06891786
115SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.05915565
116CTCF_27219007_Chip-Seq_Bcells_Human1.05868650
117KDM2B_26808549_Chip-Seq_K562_Human1.05442070
118BCL6_27268052_Chip-Seq_Bcells_Human1.05088105
119RARA_24833708_ChIP-Seq_LIVER_Mouse1.05024139
120TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.04713447
121CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.04228257
122UTX_26944678_Chip-Seq_JUKART_Human1.03636318
123ETS1_21867929_ChIP-Seq_TH2_Mouse1.02908055
124SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.02630825
125SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.02546223
126ATF3_27146783_Chip-Seq_COLON_Human1.02394277
127E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.02147892
128PU.1_20513432_ChIP-Seq_Bcells_Mouse1.02068850
129AR_25329375_ChIP-Seq_VCAP_Human1.01490873
130MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.01326968
131SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01129905
132CTCF_21964334_Chip-Seq_Bcells_Human1.00956729
133IGF1R_20145208_ChIP-Seq_DFB_Human1.00809119
134* FOXP1_21924763_ChIP-Seq_HESCs_Human0.99972454
135PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98925832
136GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98314176
137SMAD3_21741376_ChIP-Seq_ESCs_Human0.97779982
138GATA1_26923725_Chip-Seq_HPCs_Mouse0.97280092
139OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97171472
140RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.97051851
141IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.95391031
142CBP_20019798_ChIP-Seq_JUKART_Human0.95391031
143AR_19668381_ChIP-Seq_PC3_Human0.95335193
144ZNF263_19887448_ChIP-Seq_K562_Human0.95322062
145MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94960024
146PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.94503340
147SMC4_20622854_ChIP-Seq_HELA_Human0.93927266
148* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.93791713
149PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.93590743
150OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.93262755
151WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.93232870
152SRY_22984422_ChIP-ChIP_TESTIS_Rat0.93000464
153SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.92918211
154CBX2_27304074_Chip-Seq_ESCs_Mouse0.92679820
155PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.91082104
156TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.90316657
157TOP2B_26459242_ChIP-Seq_MCF-7_Human0.89199614
158WT1_25993318_ChIP-Seq_PODOCYTE_Human0.88533328
159TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.87888164
160TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.85189640
161VDR_22108803_ChIP-Seq_LS180_Human0.84892528
162TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.84319447
163FLI1_21867929_ChIP-Seq_TH2_Mouse0.83788518
164* P53_22127205_ChIP-Seq_FIBROBLAST_Human0.83419970
165MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.83099306
166STAT3_23295773_ChIP-Seq_U87_Human0.82970646
167* KLF4_19829295_ChIP-Seq_ESCs_Human0.82232643
168* PRDM14_20953172_ChIP-Seq_ESCs_Human0.81820175
169SMAD3_21741376_ChIP-Seq_EPCs_Human0.81205150
170ELK4_26923725_Chip-Seq_MESODERM_Mouse0.80001327
171ZFP57_27257070_Chip-Seq_ESCs_Mouse0.79922600
172* LXR_22292898_ChIP-Seq_THP-1_Human0.78996738
173* CTCF_18555785_ChIP-Seq_MESCs_Mouse0.78688331
174TDRD3_21172665_ChIP-Seq_MCF-7_Human0.77938871
175EP300_21415370_ChIP-Seq_HL-1_Mouse0.77647138
176YAP1_20516196_ChIP-Seq_MESCs_Mouse0.76628967
177TCF4_23295773_ChIP-Seq_U87_Human0.76226608

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.74607361
2MP0005451_abnormal_body_composition4.63638708
3MP0003880_abnormal_central_pattern4.25808408
4MP0003705_abnormal_hypodermis_morpholog4.13116784
5MP0003635_abnormal_synaptic_transmissio3.75163440
6MP0004270_analgesia3.51049305
7MP0009278_abnormal_bone_marrow3.13966223
8MP0002063_abnormal_learning/memory/cond2.98368848
9MP0001968_abnormal_touch/_nociception2.93470415
10MP0009745_abnormal_behavioral_response2.89741055
11MP0005058_abnormal_lysosome_morphology2.82538589
12MP0002064_seizures2.77554254
13MP0009046_muscle_twitch2.60115698
14MP0009840_abnormal_foam_cell2.56025903
15MP0003329_amyloid_beta_deposits2.53196438
16MP0002734_abnormal_mechanical_nocicepti2.52760111
17MP0002735_abnormal_chemical_nociception2.45360492
18MP0003123_paternal_imprinting2.43280746
19MP0002837_dystrophic_cardiac_calcinosis2.38709417
20MP0005423_abnormal_somatic_nervous2.36611844
21MP0002572_abnormal_emotion/affect_behav2.35773373
22MP0002736_abnormal_nociception_after2.34395350
23MP0002272_abnormal_nervous_system2.33732623
24MP0004185_abnormal_adipocyte_glucose2.30632727
25MP0005076_abnormal_cell_differentiation2.28877583
26MP0005410_abnormal_fertilization2.26246214
27MP0005409_darkened_coat_color2.21980050
28MP0000751_myopathy2.18638269
29MP0008260_abnormal_autophagy2.17479072
30MP0000678_abnormal_parathyroid_gland2.06121835
31MP0002733_abnormal_thermal_nociception2.03370151
32MP0001970_abnormal_pain_threshold1.98768118
33MP0006276_abnormal_autonomic_nervous1.98668735
34MP0001486_abnormal_startle_reflex1.92517675
35MP0001529_abnormal_vocalization1.88275422
36MP0008569_lethality_at_weaning1.88176551
37MP0001440_abnormal_grooming_behavior1.86777931
38MP0002184_abnormal_innervation1.85814535
39MP0004811_abnormal_neuron_physiology1.83847059
40MP0002909_abnormal_adrenal_gland1.83689100
41MP0002089_abnormal_postnatal_growth/wei1.82601301
42MP0000003_abnormal_adipose_tissue1.82324413
43MP0003646_muscle_fatigue1.81141742
44MP0002067_abnormal_sensory_capabilities1.80858840
45MP0002249_abnormal_larynx_morphology1.79302362
46MP0001346_abnormal_lacrimal_gland1.78394111
47MP0004858_abnormal_nervous_system1.74080753
48MP0001849_ear_inflammation1.73470542
49MP0000750_abnormal_muscle_regeneration1.72219954
50MP0000778_abnormal_nervous_system1.67042466
51MP0003111_abnormal_nucleus_morphology1.66353901
52MP0000013_abnormal_adipose_tissue1.64484125
53MP0005666_abnormal_adipose_tissue1.63316069
54MP0004145_abnormal_muscle_electrophysio1.60916805
55MP0005375_adipose_tissue_phenotype1.59782584
56MP0010030_abnormal_orbit_morphology1.58892197
57MP0001984_abnormal_olfaction1.54325185
58MP0004215_abnormal_myocardial_fiber1.54021136
59MP0002822_catalepsy1.52900347
60MP0001501_abnormal_sleep_pattern1.52832122
61MP0002557_abnormal_social/conspecific_i1.52820185
62MP0004233_abnormal_muscle_weight1.52660458
63MP0001348_abnormal_lacrimal_gland1.51941902
64MP0002877_abnormal_melanocyte_morpholog1.51479517
65MP0000955_abnormal_spinal_cord1.50733090
66MP0000733_abnormal_muscle_development1.50051543
67MP0005386_behavior/neurological_phenoty1.49582201
68MP0004924_abnormal_behavior1.49582201
69MP0005257_abnormal_intraocular_pressure1.44842353
70MP0003879_abnormal_hair_cell1.40036492
71MP0002066_abnormal_motor_capabilities/c1.39430055
72MP0003633_abnormal_nervous_system1.37378362
73MP0002882_abnormal_neuron_morphology1.35944359
74MP0000747_muscle_weakness1.34963399
75MP0004130_abnormal_muscle_cell1.29733691
76MP0009672_abnormal_birth_weight1.28611901
77MP0001905_abnormal_dopamine_level1.27395452
78MP0009780_abnormal_chondrocyte_physiolo1.25462133
79MP0003172_abnormal_lysosome_physiology1.22248420
80MP0005646_abnormal_pituitary_gland1.21026291
81MP0001502_abnormal_circadian_rhythm1.19443189
82MP0004036_abnormal_muscle_relaxation1.19110838
83MP0004510_myositis1.17082223
84MP0000604_amyloidosis1.15063509
85MP0003693_abnormal_embryo_hatching1.11451551
86MP0010386_abnormal_urinary_bladder1.09827650
87MP0000681_abnormal_thyroid_gland1.09220374
88MP0003631_nervous_system_phenotype1.09091259
89MP0003122_maternal_imprinting1.08181907
90MP0003303_peritoneal_inflammation1.07568402
91MP0001730_embryonic_growth_arrest1.07294485
92MP0000749_muscle_degeneration1.06474686
93MP0003453_abnormal_keratinocyte_physiol1.05843498
94MP0002152_abnormal_brain_morphology1.04235205
95MP0003191_abnormal_cellular_cholesterol1.03053684
96MP0002229_neurodegeneration1.01358460
97MP0005551_abnormal_eye_electrophysiolog1.00799703
98MP0005623_abnormal_meninges_morphology1.00168588
99MP0000350_abnormal_cell_proliferation1.00047922
100MP0005397_hematopoietic_system_phenotyp0.99439127
101MP0001545_abnormal_hematopoietic_system0.99439127
102MP0003634_abnormal_glial_cell0.99001372
103MP0002638_abnormal_pupillary_reflex0.97682918
104MP0003698_abnormal_male_reproductive0.97184748
105MP0004085_abnormal_heartbeat0.97132305
106MP0004142_abnormal_muscle_tone0.96697492
107MP0004084_abnormal_cardiac_muscle0.96368295
108MP0002234_abnormal_pharynx_morphology0.95372714
109MP0005501_abnormal_skin_physiology0.93458817
110MP0003137_abnormal_impulse_conducting0.91873074
111MP0005621_abnormal_cell_physiology0.90473343
112MP0000920_abnormal_myelination0.90049553
113MP0002080_prenatal_lethality0.89891942
114MP0005670_abnormal_white_adipose0.89766727
115MP0005620_abnormal_muscle_contractility0.88769499
116MP0010630_abnormal_cardiac_muscle0.87223544
117MP0005535_abnormal_body_temperature0.86967160
118MP0002069_abnormal_eating/drinking_beha0.85467772
119MP0003091_abnormal_cell_migration0.83744326
120MP0009379_abnormal_foot_pigmentation0.83613385
121MP0004484_altered_response_of0.83495271
122MP0004808_abnormal_hematopoietic_stem0.83200220
123MP0000759_abnormal_skeletal_muscle0.82910278
124MP0004885_abnormal_endolymph0.82277898
125MP0005369_muscle_phenotype0.81247704
126MP0002090_abnormal_vision0.80633868
127MP0003566_abnormal_cell_adhesion0.80406746
128MP0008874_decreased_physiological_sensi0.79913141
129MP0005187_abnormal_penis_morphology0.79287925
130MP0005330_cardiomyopathy0.79103550
131MP0002269_muscular_atrophy0.78254686
132MP0006035_abnormal_mitochondrial_morpho0.76616595
133MP0003690_abnormal_glial_cell0.76168218
134MP0001915_intracranial_hemorrhage0.75414400
135MP0000313_abnormal_cell_death0.75372070
136MP0003077_abnormal_cell_cycle0.75293974
137MP0002752_abnormal_somatic_nervous0.74534853
138MP0002970_abnormal_white_adipose0.74364031
139MP0008961_abnormal_basal_metabolism0.74182605
140MP0000534_abnormal_ureter_morphology0.72705629
141MP0004087_abnormal_muscle_fiber0.72587734
142MP0003948_abnormal_gas_homeostasis0.71005336
143MP0003221_abnormal_cardiomyocyte_apopto0.70904903
144MP0002106_abnormal_muscle_physiology0.69991147
145MP0001299_abnormal_eye_distance/0.69932215
146MP0002653_abnormal_ependyma_morphology0.69541036
147MP0002332_abnormal_exercise_endurance0.68562444
148MP0002971_abnormal_brown_adipose0.68270266
149MP0003385_abnormal_body_wall0.67771895
150MP0005167_abnormal_blood-brain_barrier0.67698293
151MP0009931_abnormal_skin_appearance0.67678722
152MP0005645_abnormal_hypothalamus_physiol0.66523509
153MP0003656_abnormal_erythrocyte_physiolo0.66302924
154MP0003984_embryonic_growth_retardation0.65985393
155MP0003115_abnormal_respiratory_system0.65721874
156MP0003942_abnormal_urinary_system0.65389761
157MP0005384_cellular_phenotype0.65351415
158MP0001270_distended_abdomen0.65038759
159MP0005380_embryogenesis_phenotype0.64684736
160MP0001672_abnormal_embryogenesis/_devel0.64684736
161MP0002796_impaired_skin_barrier0.64510259
162MP0001664_abnormal_digestion0.64493249
163MP0003632_abnormal_nervous_system0.64459178
164MP0001765_abnormal_ion_homeostasis0.62611960
165MP0004043_abnormal_pH_regulation0.62121835
166MP0003787_abnormal_imprinting0.60938260
167MP0002972_abnormal_cardiac_muscle0.58961439
168MP0003956_abnormal_body_size0.56415863
169MP0006072_abnormal_retinal_apoptosis0.56240528

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.93712303
2Myokymia (HP:0002411)5.45825843
3Visual hallucinations (HP:0002367)4.63783628
4Focal seizures (HP:0007359)4.18545058
5Hyperacusis (HP:0010780)4.00826388
6Ankle clonus (HP:0011448)3.82753205
7Supranuclear gaze palsy (HP:0000605)3.67076324
8Epileptic encephalopathy (HP:0200134)3.56670185
9Atonic seizures (HP:0010819)3.52008529
10Absence seizures (HP:0002121)3.27792713
11Progressive cerebellar ataxia (HP:0002073)3.27245471
12Abnormality of the lower motor neuron (HP:0002366)3.25349744
13Mutism (HP:0002300)3.07335954
14Depression (HP:0000716)3.06751387
15Action tremor (HP:0002345)3.06159638
16Achilles tendon contracture (HP:0001771)3.00409158
17Neurofibrillary tangles (HP:0002185)2.98752016
18Truncal ataxia (HP:0002078)2.92639354
19Pheochromocytoma (HP:0002666)2.90293965
20Febrile seizures (HP:0002373)2.90229459
21Termporal pattern (HP:0011008)2.89892931
22Insidious onset (HP:0003587)2.89892931
23Amyotrophic lateral sclerosis (HP:0007354)2.89133332
24Ragged-red muscle fibers (HP:0003200)2.87819286
25Dialeptic seizures (HP:0011146)2.85828933
26Neuroendocrine neoplasm (HP:0100634)2.85204585
27Cerebral inclusion bodies (HP:0100314)2.83569508
28Generalized tonic-clonic seizures (HP:0002069)2.80961141
29Exercise-induced myalgia (HP:0003738)2.76947849
30Obstructive sleep apnea (HP:0002870)2.75636981
31Poor eye contact (HP:0000817)2.72736540
32Distal lower limb amyotrophy (HP:0008944)2.72112623
33Abnormal eating behavior (HP:0100738)2.70132026
34Progressive muscle weakness (HP:0003323)2.68222171
35Distal upper limb amyotrophy (HP:0007149)2.67815735
36Upper limb amyotrophy (HP:0009129)2.67815735
37Spastic gait (HP:0002064)2.63669961
38Central scotoma (HP:0000603)2.63436930
39Impaired vibration sensation in the lower limbs (HP:0002166)2.63399398
40Shoulder girdle muscle weakness (HP:0003547)2.62928587
41Bowel incontinence (HP:0002607)2.61657799
42Abnormality of the Achilles tendon (HP:0005109)2.57374026
43Type 1 muscle fiber predominance (HP:0003803)2.55684350
44Urinary urgency (HP:0000012)2.54006932
45Increased connective tissue (HP:0009025)2.51618209
46Anxiety (HP:0000739)2.51337037
47Absent/shortened dynein arms (HP:0200106)2.49187721
48Dynein arm defect of respiratory motile cilia (HP:0012255)2.49187721
49Rapidly progressive (HP:0003678)2.47593534
50Progressive inability to walk (HP:0002505)2.47125046
51Abnormal large intestine physiology (HP:0012700)2.45467003
52Polyphagia (HP:0002591)2.44266835
53Abnormal social behavior (HP:0012433)2.43846843
54Impaired social interactions (HP:0000735)2.43846843
55Pointed chin (HP:0000307)2.43288001
56Hyperthyroidism (HP:0000836)2.41331462
57Abnormality of skeletal muscle fiber size (HP:0012084)2.39768805
58Reticulocytosis (HP:0001923)2.38544837
59Abnormal gallbladder physiology (HP:0012438)2.38319929
60Cholecystitis (HP:0001082)2.38319929
61Protrusio acetabuli (HP:0003179)2.37750046
62Distal lower limb muscle weakness (HP:0009053)2.37639770
63Truncus arteriosus (HP:0001660)2.37222712
64Muscle fiber inclusion bodies (HP:0100299)2.37003610
65Limb dystonia (HP:0002451)2.36642116
66Ulnar bowing (HP:0003031)2.34766982
67Aplasia/Hypoplasia of the brainstem (HP:0007362)2.34115728
68Hypoplasia of the brainstem (HP:0002365)2.34115728
69Thin bony cortex (HP:0002753)2.34068728
70Lower limb amyotrophy (HP:0007210)2.33078734
71Annular pancreas (HP:0001734)2.33062818
72Spinal rigidity (HP:0003306)2.32749790
73Broad distal phalanx of finger (HP:0009836)2.31534899
74Vertebral compression fractures (HP:0002953)2.30949015
75Bundle branch block (HP:0011710)2.29611627
76Nemaline bodies (HP:0003798)2.29588704
77Ventricular fibrillation (HP:0001663)2.29045420
78Foot dorsiflexor weakness (HP:0009027)2.28933760
79Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.28718612
80Urinary bladder sphincter dysfunction (HP:0002839)2.28244919
81Retinal dysplasia (HP:0007973)2.27863247
82Broad-based gait (HP:0002136)2.27424879
83Amblyopia (HP:0000646)2.26872597
84Delusions (HP:0000746)2.24153072
85Hemiparesis (HP:0001269)2.24102423
86Inability to walk (HP:0002540)2.20411345
87Abnormality of the musculature of the pelvis (HP:0001469)2.20243385
88Abnormality of the hip-girdle musculature (HP:0001445)2.20243385
89Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.19688318
90Dysmetria (HP:0001310)2.19460785
91Lower limb muscle weakness (HP:0007340)2.19196411
92Lissencephaly (HP:0001339)2.17701121
93Elfin facies (HP:0004428)2.17495099
94Hyperparathyroidism (HP:0000843)2.16260680
95Difficulty climbing stairs (HP:0003551)2.15615236
96Abnormality of the foot musculature (HP:0001436)2.12029685
97Myotonia (HP:0002486)2.11832530
98Hypoventilation (HP:0002791)2.11522184
99Overriding aorta (HP:0002623)2.11502207
100Patellar dislocation (HP:0002999)2.11439710
101Megalencephaly (HP:0001355)2.10202979
102Type II lissencephaly (HP:0007260)2.09688362
103Abnormality of the corticospinal tract (HP:0002492)2.09169998
104Hand muscle atrophy (HP:0009130)2.08982760
105Focal dystonia (HP:0004373)2.08206182
106Muscle stiffness (HP:0003552)2.08134510
107Neoplasm of the peripheral nervous system (HP:0100007)2.08104682
108Torticollis (HP:0000473)2.07662954
109Peripheral hypomyelination (HP:0007182)2.06338819
110Cerebral aneurysm (HP:0004944)2.05003439
111Long palpebral fissure (HP:0000637)2.04770452
112Pelvic girdle muscle weakness (HP:0003749)2.04702800
113Dysdiadochokinesis (HP:0002075)2.04499407
114Sudden death (HP:0001699)2.04098003
115Agitation (HP:0000713)2.03969824
116Postural instability (HP:0002172)2.02693825
117Disproportionate tall stature (HP:0001519)2.02688982
118Mitral regurgitation (HP:0001653)2.01899101
119Neuronal loss in central nervous system (HP:0002529)2.01242263
120Turricephaly (HP:0000262)2.00955720
121Bradykinesia (HP:0002067)2.00284050
122Gait imbalance (HP:0002141)1.99612073
123Dysmetric saccades (HP:0000641)1.98093238
124Renal duplication (HP:0000075)1.96747536
125Increased variability in muscle fiber diameter (HP:0003557)1.96423808
126Gaze-evoked nystagmus (HP:0000640)1.95894168
127Clonus (HP:0002169)1.95689025
128Excessive salivation (HP:0003781)1.94451853
129Drooling (HP:0002307)1.94451853
130Hypercortisolism (HP:0001578)1.93705207
131Athetosis (HP:0002305)1.93286092
132EEG with generalized epileptiform discharges (HP:0011198)1.92943863
133Epileptiform EEG discharges (HP:0011182)1.92727679
134Myopathic facies (HP:0002058)1.92108959
135Craniofacial dystonia (HP:0012179)1.91951947
136Hemiplegia (HP:0002301)1.91759994
137Asymmetry of the thorax (HP:0001555)1.91122062
138Global brain atrophy (HP:0002283)1.90857155
139Mildly elevated creatine phosphokinase (HP:0008180)1.89196319
140Intention tremor (HP:0002080)1.87416372
141Stridor (HP:0010307)1.86371814
142Hammertoe (HP:0001765)1.85898563
143Unsteady gait (HP:0002317)1.85211705
144Papilledema (HP:0001085)1.84638990
145Apathy (HP:0000741)1.84422401
146Hypsarrhythmia (HP:0002521)1.83624576
147Insomnia (HP:0100785)1.83498941
148Segmental peripheral demyelination/remyelination (HP:0003481)1.83228764
149Poor speech (HP:0002465)1.82901459
150Abnormality of the thoracic spine (HP:0100711)1.82606370
151Hypertensive crisis (HP:0100735)1.82295112
152Broad face (HP:0000283)1.82258108
153Rhabdomyolysis (HP:0003201)1.82074328
154Muscle hypertrophy of the lower extremities (HP:0008968)1.81941307
155Diminished motivation (HP:0000745)1.81878703
156Calf muscle hypertrophy (HP:0008981)1.80861112
157Rigidity (HP:0002063)1.80812721
158Hyperventilation (HP:0002883)1.80488761
159Rectal prolapse (HP:0002035)1.80477197
160Distal sensory impairment (HP:0002936)1.80214582
161Centrally nucleated skeletal muscle fibers (HP:0003687)1.80135438
162Shallow orbits (HP:0000586)1.74116580
163Akinesia (HP:0002304)1.74041309
164Back pain (HP:0003418)1.74012251
165Thoracic kyphosis (HP:0002942)1.73148435
166Calcaneovalgus deformity (HP:0001848)1.72519655
167EMG: myopathic abnormalities (HP:0003458)1.72095190
168Abnormality of reticulocytes (HP:0004312)1.71997080
169External ophthalmoplegia (HP:0000544)1.71688963
170Hypercalcemia (HP:0003072)1.71024847
171Thin ribs (HP:0000883)1.70795275
172Cholelithiasis (HP:0001081)1.68534600
173Abnormality of the calcaneus (HP:0008364)1.68193192
174Deep palmar crease (HP:0006191)1.67287224
175Precocious puberty (HP:0000826)1.67092530
176Hemorrhage of the eye (HP:0011885)1.66007568
177Ulnar deviation of the wrist (HP:0003049)1.65141567
178Renovascular hypertension (HP:0100817)1.63539425
179Myoglobinuria (HP:0002913)1.61780196
180Axonal loss (HP:0003447)1.61399452
181Bulbar palsy (HP:0001283)1.61297880
182Progressive external ophthalmoplegia (HP:0000590)1.59305127
183Atelectasis (HP:0100750)1.58860955
184Flat cornea (HP:0007720)1.58127901

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.54427706
2MAP3K93.49169205
3MARK13.26328133
4PRPF4B3.18721175
5EPHA42.96918142
6EEF2K2.86942171
7MINK12.72715110
8MAP3K42.68613572
9SMG12.68049249
10PDK32.53335222
11PDK42.53335222
12ERN12.49324810
13NME22.39593265
14SIK12.21700645
15CDK122.19976384
16PAK62.13749394
17KSR22.09307498
18IRAK32.08482695
19PRKD32.04817188
20MAP2K72.02529981
21ARAF2.02269049
22PHKG21.87313928
23PHKG11.87313928
24TTN1.85753096
25NTRK21.82048652
26FES1.72945588
27NTRK11.68675612
28CAMKK11.68629985
29DAPK21.68099852
30NEK11.67618223
31LMTK21.65991061
32MAP3K121.65174485
33PKN21.63598502
34TESK11.49451970
35MAP2K41.47325366
36CDK51.44687596
37PNCK1.43674973
38KSR11.40150291
39MAP2K31.36737411
40PIM21.33489698
41CAMKK21.31753342
42WNK31.31243713
43TYRO31.29883755
44TAOK21.29046935
45PTK2B1.28065296
46RIPK41.25499106
47MAP3K101.25121631
48CCNB11.23490022
49FGFR41.21843000
50PDGFRA1.20329233
51MAPK131.19672220
52DAPK11.19479683
53CDK191.17337292
54TRIB31.16672344
55PDK21.15752448
56UHMK11.15671023
57MTOR1.14230016
58STK381.12113412
59CDK141.10865969
60CASK1.09141406
61PRKD21.08618602
62RET1.08055539
63LIMK11.01978772
64SCYL20.99779036
65CDK180.98869747
66MAPK110.97818798
67CDK150.97241367
68PRKCG0.96278334
69CSNK1G20.95243911
70PLK20.94373258
71GRK50.92562844
72PINK10.90167146
73CDK11A0.89381347
74ICK0.88610812
75FER0.87967552
76TAOK10.81174899
77RAF10.79170482
78BRAF0.79169565
79PDK10.77366364
80CDC42BPA0.76742693
81CDK40.76541548
82MAP2K20.76538881
83RPS6KA20.75682299
84SIK20.74852652
85CAMK2B0.74540247
86CAMK2A0.74348188
87PDPK10.74281997
88WNK40.72562803
89HIPK20.71825017
90DYRK1B0.71204044
91PTK60.68076353
92LATS20.67655265
93MAP3K130.65660182
94TIE10.65072137
95STK390.64022242
96LRRK20.63579224
97RPS6KB20.63253213
98MARK20.62161855
99NME10.61588463
100SGK4940.61425440
101SGK2230.61425440
102PAK30.61290899
103PRKCH0.61202352
104CSNK1G30.60274313
105CAMK2D0.59592556
106BMX0.59322590
107RPS6KL10.59107992
108RPS6KC10.59107992
109ALK0.58736547
110MAP3K10.58457625
111TESK20.57165832
112PTK20.57154593
113DYRK20.55399938
114MAP3K80.54790343
115BRSK10.54056553
116MAPKAPK30.51501549
117CAMK10.51089488
118ROCK20.50610827
119PRKCZ0.49927925
120CAMK40.49183244
121MAPK100.48259955
122CAMK2G0.48191608
123EPHA20.48099543
124CAMK1D0.47898084
125EPHB10.47721717
126MOS0.47544472
127DAPK30.46845771
128FGR0.46505156
129AKT20.46416173
130STK110.45225291
131PAK40.45089648
132MAP2K10.44616912
133CDK70.44502750
134MAPKAPK50.44450404
135SGK30.43776733
136MAP3K20.43195955
137RIPK10.42554965
138MAP3K60.42147559
139MAP3K70.42111028
140ABL20.41340088
141DYRK1A0.41148223
142OBSCN0.40911889
143IRAK20.40838323
144PAK20.40700427
145AURKA0.40014230
146RPS6KA60.39974520
147TNIK0.39583710
148MAP3K110.38310433
149TBK10.37889890
150FYN0.37207191
151MAPK120.37172613
152ILK0.36264608
153OXSR10.36120149
154CDK20.35986955
155RPS6KA10.35237939

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.45217184
2Nicotine addiction_Homo sapiens_hsa050332.86750752
3Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.69541605
4Sulfur relay system_Homo sapiens_hsa041222.56901542
5Circadian entrainment_Homo sapiens_hsa047132.50729793
6GABAergic synapse_Homo sapiens_hsa047272.44170829
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.38598613
8Long-term potentiation_Homo sapiens_hsa047202.35252270
9Olfactory transduction_Homo sapiens_hsa047402.34928432
10Glutamatergic synapse_Homo sapiens_hsa047242.20409470
11Dopaminergic synapse_Homo sapiens_hsa047282.19257825
12Morphine addiction_Homo sapiens_hsa050322.17849432
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.12803447
14Fructose and mannose metabolism_Homo sapiens_hsa000512.12303882
15Amphetamine addiction_Homo sapiens_hsa050312.11995030
16Insulin secretion_Homo sapiens_hsa049112.00461177
17Other glycan degradation_Homo sapiens_hsa005111.98790519
18Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.89877934
19Salivary secretion_Homo sapiens_hsa049701.87865701
20Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.83266458
21Chronic myeloid leukemia_Homo sapiens_hsa052201.79720283
22Cholinergic synapse_Homo sapiens_hsa047251.78690168
23Gastric acid secretion_Homo sapiens_hsa049711.77359577
24Biosynthesis of amino acids_Homo sapiens_hsa012301.73525987
25Pentose phosphate pathway_Homo sapiens_hsa000301.71365523
26Collecting duct acid secretion_Homo sapiens_hsa049661.68707317
27Bladder cancer_Homo sapiens_hsa052191.68599029
28Renin secretion_Homo sapiens_hsa049241.66077183
29Aldosterone synthesis and secretion_Homo sapiens_hsa049251.61836748
30Cardiac muscle contraction_Homo sapiens_hsa042601.61653048
31Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.60648658
32Oxytocin signaling pathway_Homo sapiens_hsa049211.60390174
33Acute myeloid leukemia_Homo sapiens_hsa052211.54394158
34Prion diseases_Homo sapiens_hsa050201.50247612
35Taste transduction_Homo sapiens_hsa047421.49500232
36Long-term depression_Homo sapiens_hsa047301.49386791
37Cyanoamino acid metabolism_Homo sapiens_hsa004601.46220351
38Gap junction_Homo sapiens_hsa045401.45172605
39Cocaine addiction_Homo sapiens_hsa050301.44013820
40Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.38260788
41Serotonergic synapse_Homo sapiens_hsa047261.38091306
42Calcium signaling pathway_Homo sapiens_hsa040201.35955656
43Oocyte meiosis_Homo sapiens_hsa041141.34349413
44GnRH signaling pathway_Homo sapiens_hsa049121.32590873
45Vitamin B6 metabolism_Homo sapiens_hsa007501.31077794
46Notch signaling pathway_Homo sapiens_hsa043301.29887951
47Vibrio cholerae infection_Homo sapiens_hsa051101.28378329
48Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.27985059
49Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.21804228
50Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.21389649
51Estrogen signaling pathway_Homo sapiens_hsa049151.17756648
52Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.17717903
53Carbon metabolism_Homo sapiens_hsa012001.14383045
54Pancreatic cancer_Homo sapiens_hsa052121.14031945
55cGMP-PKG signaling pathway_Homo sapiens_hsa040221.07988883
56cAMP signaling pathway_Homo sapiens_hsa040241.07026192
57Thyroid cancer_Homo sapiens_hsa052161.01907639
58VEGF signaling pathway_Homo sapiens_hsa043701.00999518
59Pancreatic secretion_Homo sapiens_hsa049721.00923678
60Dilated cardiomyopathy_Homo sapiens_hsa054140.98252423
61Adipocytokine signaling pathway_Homo sapiens_hsa049200.96623285
62DNA replication_Homo sapiens_hsa030300.96414756
63Base excision repair_Homo sapiens_hsa034100.96163896
64Vascular smooth muscle contraction_Homo sapiens_hsa042700.95124546
65Galactose metabolism_Homo sapiens_hsa000520.93413026
66Glioma_Homo sapiens_hsa052140.91529800
67Type II diabetes mellitus_Homo sapiens_hsa049300.88955245
68Lysine degradation_Homo sapiens_hsa003100.88809614
69Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.88596841
70Axon guidance_Homo sapiens_hsa043600.86984882
71Glucagon signaling pathway_Homo sapiens_hsa049220.86536556
72Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.85542385
73Alzheimers disease_Homo sapiens_hsa050100.85062650
74Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.84499985
75Inositol phosphate metabolism_Homo sapiens_hsa005620.84440631
76Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.82722460
77Parkinsons disease_Homo sapiens_hsa050120.82412654
78Carbohydrate digestion and absorption_Homo sapiens_hsa049730.82024956
79mRNA surveillance pathway_Homo sapiens_hsa030150.81082780
80Arginine and proline metabolism_Homo sapiens_hsa003300.80698854
81AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.80573852
82Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.80339847
83* Endocytosis_Homo sapiens_hsa041440.80115272
84Oxidative phosphorylation_Homo sapiens_hsa001900.79626839
85Glycosaminoglycan degradation_Homo sapiens_hsa005310.77971767
86Neurotrophin signaling pathway_Homo sapiens_hsa047220.77384674
87Phosphatidylinositol signaling system_Homo sapiens_hsa040700.77221723
88B cell receptor signaling pathway_Homo sapiens_hsa046620.76822641
89Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.75639348
90Arginine biosynthesis_Homo sapiens_hsa002200.74702907
91HIF-1 signaling pathway_Homo sapiens_hsa040660.73656466
92Insulin resistance_Homo sapiens_hsa049310.72407121
93Melanogenesis_Homo sapiens_hsa049160.72273057
94Phospholipase D signaling pathway_Homo sapiens_hsa040720.71534088
95Dorso-ventral axis formation_Homo sapiens_hsa043200.70382351
96Alcoholism_Homo sapiens_hsa050340.69748983
97ErbB signaling pathway_Homo sapiens_hsa040120.69379644
98Thyroid hormone synthesis_Homo sapiens_hsa049180.68883751
99Prolactin signaling pathway_Homo sapiens_hsa049170.68669744
100Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.67840579
101Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67823289
102Phototransduction_Homo sapiens_hsa047440.67459912
103Circadian rhythm_Homo sapiens_hsa047100.67118594
104Lysosome_Homo sapiens_hsa041420.65192875
105Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.64536955
106Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.63553674
107Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.61871548
108Sphingolipid signaling pathway_Homo sapiens_hsa040710.61461786
109Regulation of autophagy_Homo sapiens_hsa041400.60164987
110MicroRNAs in cancer_Homo sapiens_hsa052060.57662900
111Insulin signaling pathway_Homo sapiens_hsa049100.56996323
112Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.55787946
113MAPK signaling pathway_Homo sapiens_hsa040100.55684422
114Renal cell carcinoma_Homo sapiens_hsa052110.55443327
115Thyroid hormone signaling pathway_Homo sapiens_hsa049190.54130421
116Huntingtons disease_Homo sapiens_hsa050160.53071539
117Apoptosis_Homo sapiens_hsa042100.51613982
118mTOR signaling pathway_Homo sapiens_hsa041500.51343909
119Hepatitis B_Homo sapiens_hsa051610.51219700
120Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.50979521
1212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.50747919
122Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.50075054
123Choline metabolism in cancer_Homo sapiens_hsa052310.50052794
124Pyruvate metabolism_Homo sapiens_hsa006200.49180669
125Phenylalanine metabolism_Homo sapiens_hsa003600.48546449
126Proteoglycans in cancer_Homo sapiens_hsa052050.48539193
127AMPK signaling pathway_Homo sapiens_hsa041520.48394838
128FoxO signaling pathway_Homo sapiens_hsa040680.47739385
129Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.47138558
130Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46535559
131Shigellosis_Homo sapiens_hsa051310.46345950
132Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.46086526
133Hepatitis C_Homo sapiens_hsa051600.45653410
134HTLV-I infection_Homo sapiens_hsa051660.45213217
135SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44814494
136Endometrial cancer_Homo sapiens_hsa052130.42971599
137Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.42621355
138Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.41182453
139Ras signaling pathway_Homo sapiens_hsa040140.39960241
140Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.38634856
141Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.37600977
142Glycerophospholipid metabolism_Homo sapiens_hsa005640.36693550
143Central carbon metabolism in cancer_Homo sapiens_hsa052300.33660897
144Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.33359713
145Rap1 signaling pathway_Homo sapiens_hsa040150.32293394
146Non-small cell lung cancer_Homo sapiens_hsa052230.30206764
147Colorectal cancer_Homo sapiens_hsa052100.29106320

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »